JPS54117404A - Reductive desulfurization of sulfides - Google Patents

Reductive desulfurization of sulfides

Info

Publication number
JPS54117404A
JPS54117404A JP2455478A JP2455478A JPS54117404A JP S54117404 A JPS54117404 A JP S54117404A JP 2455478 A JP2455478 A JP 2455478A JP 2455478 A JP2455478 A JP 2455478A JP S54117404 A JPS54117404 A JP S54117404A
Authority
JP
Japan
Prior art keywords
alkyl
carboxyl
aryl
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2455478A
Other languages
Japanese (ja)
Other versions
JPS614370B2 (en
Inventor
Genichi Dobashi
Katsuyuki Ogura
Shuichi Mitamura
Tamio Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP2455478A priority Critical patent/JPS54117404A/en
Publication of JPS54117404A publication Critical patent/JPS54117404A/en
Publication of JPS614370B2 publication Critical patent/JPS614370B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare a compound useful as medicines, agricultural chemicals, etc., selectively and in high yield, by the reductive desulfurization of a sulfide compound with low-cost, easily post-treatable metallic Na-alcohol in the presence of a specific ether.
CONSTITUTION: A compound of formula I is prepared in high yield, by the reductive desulfurization of a sulfide compound of formula I (R is alkyl or aryl; R1 is H or alkyl; R2 is alkyl, aryl or 1-alkenyl; X is H, alkl or carboxyl; with the proviso that R2 is aryl or 1-alkenyl, or X is carboxyl when R is alkyl) with metallic Na in the presence of an alcohol, and an ether such as THF or diethyl ether.
USE: Among the formula II, ibuprofen (R1=methyl, R2=p-isobutylphenyl, X=carboxyl), etc. are useful as antiphlogistics and analgesics.
COPYRIGHT: (C)1979,JPO&Japio
JP2455478A 1978-03-06 1978-03-06 Reductive desulfurization of sulfides Granted JPS54117404A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2455478A JPS54117404A (en) 1978-03-06 1978-03-06 Reductive desulfurization of sulfides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2455478A JPS54117404A (en) 1978-03-06 1978-03-06 Reductive desulfurization of sulfides

Publications (2)

Publication Number Publication Date
JPS54117404A true JPS54117404A (en) 1979-09-12
JPS614370B2 JPS614370B2 (en) 1986-02-08

Family

ID=12141366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2455478A Granted JPS54117404A (en) 1978-03-06 1978-03-06 Reductive desulfurization of sulfides

Country Status (1)

Country Link
JP (1) JPS54117404A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0529444A2 (en) * 1991-08-30 1993-03-03 Bayer Ag 2-Arylpropenic acids and their utilisation in the preparation of 5-ketoprofen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0529444A2 (en) * 1991-08-30 1993-03-03 Bayer Ag 2-Arylpropenic acids and their utilisation in the preparation of 5-ketoprofen
EP0529444A3 (en) * 1991-08-30 1994-09-07 Bayer Ag 2-arylpropenic acids and their utilisation in the preparation of 5-ketoprofen

Also Published As

Publication number Publication date
JPS614370B2 (en) 1986-02-08

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