JPS5371062A - 55*hydroxy*substituted*methyl** 2*33dihydrobenzofurann22 carboxylate and derivatives thereof - Google Patents

55*hydroxy*substituted*methyl** 2*33dihydrobenzofurann22 carboxylate and derivatives thereof

Info

Publication number
JPS5371062A
JPS5371062A JP14578177A JP14578177A JPS5371062A JP S5371062 A JPS5371062 A JP S5371062A JP 14578177 A JP14578177 A JP 14578177A JP 14578177 A JP14578177 A JP 14578177A JP S5371062 A JPS5371062 A JP S5371062A
Authority
JP
Japan
Prior art keywords
carboxylate
hydroxy
derivatives
substituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14578177A
Other languages
English (en)
Japanese (ja)
Inventor
Jiee Kuragoo Jiyuniya Edowaado
Daburiyu Uorutaasudoru Otsutoo
Efu Hofuman Uiriamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5371062A publication Critical patent/JPS5371062A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP14578177A 1976-12-06 1977-12-06 55*hydroxy*substituted*methyl** 2*33dihydrobenzofurann22 carboxylate and derivatives thereof Pending JPS5371062A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,840 US4100294A (en) 1976-12-06 1976-12-06 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives

Publications (1)

Publication Number Publication Date
JPS5371062A true JPS5371062A (en) 1978-06-24

Family

ID=25006865

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14578177A Pending JPS5371062A (en) 1976-12-06 1977-12-06 55*hydroxy*substituted*methyl** 2*33dihydrobenzofurann22 carboxylate and derivatives thereof

Country Status (8)

Country Link
US (1) US4100294A (enExample)
JP (1) JPS5371062A (enExample)
DE (1) DE2754068A1 (enExample)
DK (1) DK520077A (enExample)
FR (1) FR2372818A1 (enExample)
GB (1) GB1555837A (enExample)
NL (1) NL7712800A (enExample)
SE (1) SE7713244L (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189496A (en) * 1978-02-16 1980-02-19 Merck & Co., Inc. 2,3-Dihydro-5-thienylmethyl and furylmethyl-6-substituted and 6,7-disubstituted-benzofuran-2-carboxylic acid
EP0019955A1 (en) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarboxylic acid derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
US4456612A (en) * 1981-09-08 1984-06-26 Abbott Laboratories Benzisoxazole carboxylic acids
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4490384A (en) * 1983-02-23 1984-12-25 Abbott Laboratories Benzisoxazole carboxylic acids
US4560558A (en) * 1983-05-16 1985-12-24 Abbott Laboratories 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US4713393A (en) * 1985-04-25 1987-12-15 Merck & Co., Inc. Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
US4654365A (en) * 1985-09-26 1987-03-31 Merck & Co., Inc. 2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
SG11201504799QA (en) 2012-12-17 2015-07-30 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
EP2931712B8 (en) 2012-12-17 2018-05-23 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087542A (en) * 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

Also Published As

Publication number Publication date
NL7712800A (nl) 1978-06-08
DK520077A (da) 1978-06-07
GB1555837A (en) 1979-11-14
DE2754068A1 (de) 1978-06-08
FR2372818B1 (enExample) 1981-11-27
FR2372818A1 (fr) 1978-06-30
SE7713244L (sv) 1978-06-07
US4100294A (en) 1978-07-11

Similar Documents

Publication Publication Date Title
JPS52105162A (en) Phthleic derivatives and preparation thereof
JPS5371062A (en) 55*hydroxy*substituted*methyl** 2*33dihydrobenzofurann22 carboxylate and derivatives thereof
IL59567A0 (en) Oxiranylmethyltetrahydropyran derivative and its preparation
JPS5334771A (en) Thiazolidine derivative and its preparation
JPS5334800A (en) 55alkoxyimidazo *1*22a* quinolinee22carboxylic acid and derivative thereof
JPS549281A (en) 44aminomethyll11*3*3*33 triarylpropyl**44 arylpyperidine and derivative thereof
JPS53132596A (en) 22*2*22diaryllalkyl**11azabicyclo *2*2*2*octane and derivative thereof
HK60184A (en) 4-hydroxyphenylalkanolamine derivatives and preparation thereof
JPS5344539A (en) 22*33phenyll22 aminopropionyloxy* derivatives
JPS5392784A (en) 1*44dihydropyridine derivative and vasolidator drugs containing same
JPS52148061A (en) 66carboxymethyl thiocortisol and derivatives thereof
JPS52139040A (en) 22 and 33substituted enekephlin
JPS53127491A (en) 33*22aminoethylthio**66ethyll77oxoo 11azabicyclo*3*2*0*heptaa22enee22 carboxylate
JPS53132582A (en) 33*11piperadinyl**1*2*44benzotriazine and nnoxide
ZA781598B (en) 4-alkylthio-2-trifluoromethylalkanesulfonanilides and derivatives thereof
GB2023599B (en) Thienopyridone and furopyridone derivatives
JPS5356607A (en) 4*66dii00*aminoglycosyl** 1*33diaminocicrytol derivatives
JPS5488272A (en) 3*44methanoopyrrolidine derivatives and their manufacture
JPS5365853A (en) 15 * 166dihydroxyprostaglandin and like
GB1542775A (en) Seldomycin factor 5 derivatives
JPS5283640A (en) Benzyllphenoxyalkane carboxylate and derivatives thereof
JPS54106465A (en) 16*177pyrazolinoo and 16*177isopyrazolinoo 1*44pregnadiene derivative
JPS54103863A (en) 5*66dihydrooprostacycline derivative and its manufacture
JPS52116462A (en) 22oxoopyrrolidine derivative and preparation thereof
GB1540347A (en) 4-pyridyl-formimidoylglycyl-d-phenyl-glycine and derivatives