SE7713244L - 5-(hydroxi(substituerad)metyl)-2,3-dihydrobensofuran-2-karboxylsyra och dess derivat - Google Patents

5-(hydroxi(substituerad)metyl)-2,3-dihydrobensofuran-2-karboxylsyra och dess derivat

Info

Publication number
SE7713244L
SE7713244L SE7713244A SE7713244A SE7713244L SE 7713244 L SE7713244 L SE 7713244L SE 7713244 A SE7713244 A SE 7713244A SE 7713244 A SE7713244 A SE 7713244A SE 7713244 L SE7713244 L SE 7713244L
Authority
SE
Sweden
Prior art keywords
dihydrobenzofuran
hydroxy
derivatives
substituted
methyl
Prior art date
Application number
SE7713244A
Other languages
English (en)
Swedish (sv)
Inventor
Jr E J Cragoe
Jr O W Woltersdorf
W F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7713244L publication Critical patent/SE7713244L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7713244A 1976-12-06 1977-11-23 5-(hydroxi(substituerad)metyl)-2,3-dihydrobensofuran-2-karboxylsyra och dess derivat SE7713244L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/747,840 US4100294A (en) 1976-12-06 1976-12-06 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives

Publications (1)

Publication Number Publication Date
SE7713244L true SE7713244L (sv) 1978-06-07

Family

ID=25006865

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7713244A SE7713244L (sv) 1976-12-06 1977-11-23 5-(hydroxi(substituerad)metyl)-2,3-dihydrobensofuran-2-karboxylsyra och dess derivat

Country Status (8)

Country Link
US (1) US4100294A (xx)
JP (1) JPS5371062A (xx)
DE (1) DE2754068A1 (xx)
DK (1) DK520077A (xx)
FR (1) FR2372818A1 (xx)
GB (1) GB1555837A (xx)
NL (1) NL7712800A (xx)
SE (1) SE7713244L (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189496A (en) * 1978-02-16 1980-02-19 Merck & Co., Inc. 2,3-Dihydro-5-thienylmethyl and furylmethyl-6-substituted and 6,7-disubstituted-benzofuran-2-carboxylic acid
EP0019955A1 (en) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarboxylic acid derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
US4456612A (en) * 1981-09-08 1984-06-26 Abbott Laboratories Benzisoxazole carboxylic acids
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4490384A (en) * 1983-02-23 1984-12-25 Abbott Laboratories Benzisoxazole carboxylic acids
US4560558A (en) * 1983-05-16 1985-12-24 Abbott Laboratories 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4713393A (en) * 1985-04-25 1987-12-15 Merck & Co., Inc. Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
US4654365A (en) * 1985-09-26 1987-03-31 Merck & Co., Inc. 2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
AU2013363218B2 (en) 2012-12-17 2018-03-15 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
KR20150095870A (ko) 2012-12-17 2015-08-21 패리온 사이언스 인코퍼레이티드 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087542A (en) 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids

Also Published As

Publication number Publication date
JPS5371062A (en) 1978-06-24
DE2754068A1 (de) 1978-06-08
NL7712800A (nl) 1978-06-08
FR2372818A1 (fr) 1978-06-30
DK520077A (da) 1978-06-07
FR2372818B1 (xx) 1981-11-27
GB1555837A (en) 1979-11-14
US4100294A (en) 1978-07-11

Similar Documents

Publication Publication Date Title
SE7713244L (sv) 5-(hydroxi(substituerad)metyl)-2,3-dihydrobensofuran-2-karboxylsyra och dess derivat
SE7802379L (sv) Substituerade fenoxibensyloxikarbonylderivat till anvendning som insekticider och akaricider
IT7825256A0 (it) Tampone catameniale.
FI783189A (fi) Alkanoylprolin-derivat och deras homologer, deras framstaellning och anvaendning
FI780954A (fi) 5-(4-(diarylmetyl)-1-piperazinylalkyl) bensimidazolderivat
DK543178A (da) Thiodydantoinderivater
SE7804446L (sv) Tienamycinderivat
NL7800262A (nl) Oxazolinoazetidine derivaten.
SE7805260L (sv) Alkylendiaminderivat
NL183615C (nl) Piezoelectrische kristallijne film.
FI783033A (fi) Foerfarande foer framstaellning av 4,5-dihydro-2-alkoxi-karbonylamino-5-karbocyklisk-aryl-imidatsoler och deras derivat
NL7801882A (nl) Fenylbenzimidazolylfuranderivaten.
NO831790L (no) Nye pyrido-indol-derivater.
NL7811070A (nl) 2-imino-imidazolidinederivaten.
FI780344A (fi) Oxadiazolopyrimidinderivat
NL7804621A (nl) Amino-alcoholderivaten.
NL7801572A (nl) Gesubstitueerde thioureumderivaten.
SE7801046L (sv) Azacykloalkaner, azacykloalkener och derivat derav
NL183688C (nl) Piezoelectrische kristallijne film.
SE7803419L (sv) Kinazolinderivat
NL7807871A (nl) Alpha-halogeenmethylaminozuur derivaten.
NO780414L (no) Nye azetidinonderivater.
FI783944A (fi) 5-(2-anilino-alkylamino-1-hydroxialkyl)-salicylamider deras framstaellning och deras anvaendning saosom antihypertensiver
NL7801576A (nl) Benzoheterocyclylglyoxylzuurderivaten.
FI793041A (fi) N-(1-metyl-2-pyrrolidinylmetyl)-2,3-dimetoxi-5-metylsulfamoylbensamid och dess derivat dessa foereningars framstaellningsfoerfarande och deras anvaendning foer behandling av de laegre urinvaegarna