JPS52100446A - Compositions and process - Google Patents

Compositions and process

Info

Publication number
JPS52100446A
JPS52100446A JP1433777A JP1433777A JPS52100446A JP S52100446 A JPS52100446 A JP S52100446A JP 1433777 A JP1433777 A JP 1433777A JP 1433777 A JP1433777 A JP 1433777A JP S52100446 A JPS52100446 A JP S52100446A
Authority
JP
Japan
Prior art keywords
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1433777A
Other languages
English (en)
Inventor
Waruden Sumisu Haaman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of JPS52100446A publication Critical patent/JPS52100446A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP1433777A 1976-02-13 1977-02-14 Compositions and process Pending JPS52100446A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/657,739 US4029681A (en) 1976-02-13 1976-02-13 13,14-Didehydro-PG analogs

Publications (1)

Publication Number Publication Date
JPS52100446A true JPS52100446A (en) 1977-08-23

Family

ID=24638478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1433777A Pending JPS52100446A (en) 1976-02-13 1977-02-14 Compositions and process

Country Status (8)

Country Link
US (10) US4029681A (ja)
JP (1) JPS52100446A (ja)
AU (1) AU514849B2 (ja)
BE (1) BE851359A (ja)
CH (1) CH628028A5 (ja)
DE (1) DE2704933A1 (ja)
NL (1) NL7701467A (ja)
ZA (1) ZA77157B (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018473A1 (fr) * 1991-04-22 1992-10-29 Taisho Pharmaceutical Co., Ltd. Analogue de prostaglandine e¿1?
WO1994008959A1 (en) * 1992-10-20 1994-04-28 Taisho Pharmaceutical Co., Ltd. Prostaglandine derivative
WO1994027962A1 (fr) * 1993-05-26 1994-12-08 Taisho Pharmaceutical Co., Ltd. Analogue de la prostaglandine e¿1?
US5583158A (en) * 1992-10-21 1996-12-10 Taisho Pharmaceutical Co., Ltd. Prostaglandin E1 analogues
US6455584B1 (en) 1999-04-09 2002-09-24 Taisho Pharmaceutical Co., Ltd. Prostaglandin E1 derivatives
US6482990B1 (en) 1999-09-06 2002-11-19 Taisho Pharmaceutical Co., Ltd. Prostaglandin E analogues
US6613932B1 (en) 1999-09-10 2003-09-02 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
US6740772B1 (en) 1999-09-10 2004-05-25 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
US6822112B1 (en) 1999-08-13 2004-11-23 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312810A (en) * 1978-11-22 1982-01-26 The Upjohn Company 2,5-Inter-o-phenylene-3,4-dinor-5,9α-epoxy-9-deoxy-PGF1 compounds
US4294993A (en) * 1980-04-14 1981-10-13 General Electric Company Purification of bisphenol-A
DE3320260A1 (de) * 1983-06-04 1984-12-06 Bayer Ag, 5090 Leverkusen Diphenolmonoester von carbonsaeuren, ein verfahren zu ihrer herstellung, ihre verwendung zur herstellung von polyestercarbonaten, die erfindungsgemaess erhaeltlichen polyestercarbonate sowie flammwidrige formmassen enthaltend diese polyestercarbonate
US4576962A (en) * 1983-10-19 1986-03-18 The Procter & Gamble Company Prostaglandin analogues
CA1241324A (en) 1984-03-08 1988-08-30 Paul A. Aristoff Interphenylene carbacyclin derivatives
US4822819A (en) * 1986-11-07 1989-04-18 Alcon Laboratories, Inc. Use of trimoprostil and derivatives in glaucoma therapy
US4822820A (en) * 1986-11-24 1989-04-18 Alcon Laboratories, Inc. Use of tri-methyl PG-F2 a and derivatives in glaucoma therapy
US5565492A (en) * 1988-07-18 1996-10-15 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
US5173507A (en) * 1988-07-18 1992-12-22 Alcon Laboratories, Inc. Prostaglandin combinations in glaucoma therapy
FR2688634B1 (fr) * 1992-03-10 1994-06-03 Souriau & Cie Connecteur de type polygonal, notamment rectangulaire a corps central isolant.
EP0664707B1 (en) * 1992-10-13 1997-06-04 Alcon Laboratories, Inc. Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
AU7680096A (en) * 1995-12-22 1997-07-17 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5599838A (en) * 1996-02-23 1997-02-04 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
EP1598335A4 (en) * 2003-02-20 2006-04-12 Taisho Pharmaceutical Co Ltd PROSTAGLANDINE DERIVATIVES
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
CN116120268A (zh) * 2023-03-06 2023-05-16 南京华威医药科技集团有限公司 一种他氟前列素中间体杂质及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959346A (en) * 1969-03-14 1976-05-25 The Upjohn Company Racemic prostaglandins of the 2-series and analogs thereof
US3931411A (en) * 1971-06-09 1976-01-06 G. D. Searle & Co. Method for tranquilization without general depression
GB1425962A (en) * 1972-04-13 1976-02-25 Erba Carlo Spa Lactols and lactones
DE2317019A1 (de) * 1972-04-27 1973-11-08 Upjohn Co Neue 4,5-didehydro-prostaglandine
US3933899A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE2 -oxa-phenylene compounds
US3944595A (en) * 1972-10-30 1976-03-16 The Upjohn Company PGF1.sub.α -oxaphenylene compounds
US3914282A (en) * 1973-01-16 1975-10-21 Upjohn Co Prostaglandin E{HD 1{B , F{HD 1{B , and A{HD 1 {B analogs
US3962293A (en) * 1973-07-20 1976-06-08 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin F1
US3980694A (en) * 1974-04-11 1976-09-14 The Upjohn Company 4-Oxa phenyl-substituted PGA compounds
US3932463A (en) * 1974-06-03 1976-01-13 American Cyanamid Company 11-Deoxy-13-dihydro-prostaglandin-9-ketals
GB1482047A (en) * 1974-07-12 1977-08-03 Upjohn Co Bicyclohexane derivatives for use in the synthesis of prostaglandins

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018473A1 (fr) * 1991-04-22 1992-10-29 Taisho Pharmaceutical Co., Ltd. Analogue de prostaglandine e¿1?
WO1992018472A1 (en) * 1991-04-22 1992-10-29 Taisho Pharmaceutical Co., Ltd. Prostaglandin e1 analogue
US5639899A (en) * 1991-04-22 1997-06-17 Taisho Pharmaceutical Co., Ltd. Prostaglandin E1 analogues
WO1994008959A1 (en) * 1992-10-20 1994-04-28 Taisho Pharmaceutical Co., Ltd. Prostaglandine derivative
US5545666A (en) * 1992-10-20 1996-08-13 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
US5583158A (en) * 1992-10-21 1996-12-10 Taisho Pharmaceutical Co., Ltd. Prostaglandin E1 analogues
WO1994027962A1 (fr) * 1993-05-26 1994-12-08 Taisho Pharmaceutical Co., Ltd. Analogue de la prostaglandine e¿1?
US6455584B1 (en) 1999-04-09 2002-09-24 Taisho Pharmaceutical Co., Ltd. Prostaglandin E1 derivatives
US6822112B1 (en) 1999-08-13 2004-11-23 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
US6482990B1 (en) 1999-09-06 2002-11-19 Taisho Pharmaceutical Co., Ltd. Prostaglandin E analogues
US6613932B1 (en) 1999-09-10 2003-09-02 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
US6740772B1 (en) 1999-09-10 2004-05-25 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives

Also Published As

Publication number Publication date
US4087617A (en) 1978-05-02
US4156088A (en) 1979-05-22
US4119662A (en) 1978-10-10
US4151184A (en) 1979-04-24
US4087618A (en) 1978-05-02
AU514849B2 (en) 1981-03-05
BE851359A (ja) 1977-08-11
US4147879A (en) 1979-04-03
US4119664A (en) 1978-10-10
ZA77157B (en) 1977-11-30
DE2704933A1 (de) 1977-08-18
US4156089A (en) 1979-05-22
US4029681A (en) 1977-06-14
NL7701467A (nl) 1977-08-16
AU2133877A (en) 1978-07-20
CH628028A5 (de) 1982-02-15
US4118416A (en) 1978-10-03

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