JPH11511113A5 - - Google Patents

Info

Publication number
JPH11511113A5
JPH11511113A5 JP1996531337A JP53133796A JPH11511113A5 JP H11511113 A5 JPH11511113 A5 JP H11511113A5 JP 1996531337 A JP1996531337 A JP 1996531337A JP 53133796 A JP53133796 A JP 53133796A JP H11511113 A5 JPH11511113 A5 JP H11511113A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1996531337A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11511113A (ja
Filing date
Publication date
Priority claimed from GBGB9516943.9A external-priority patent/GB9516943D0/en
Application filed filed Critical
Publication of JPH11511113A publication Critical patent/JPH11511113A/ja
Publication of JPH11511113A5 publication Critical patent/JPH11511113A5/ja
Withdrawn legal-status Critical Current

Links

JP8531337A 1995-08-18 1996-08-19 シクロプロピルインドール類およびそのセコ前駆体、ならびにプロドラッグとしてのこれらの使用 Withdrawn JPH11511113A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9516943.9A GB9516943D0 (en) 1995-08-18 1995-08-18 Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
GB9516943.9 1995-08-18
PCT/NZ1996/000083 WO1997007097A1 (en) 1995-08-18 1996-08-19 Cyclopropylindoles and their seco precursors, and their use as prodrugs

Publications (2)

Publication Number Publication Date
JPH11511113A JPH11511113A (ja) 1999-09-28
JPH11511113A5 true JPH11511113A5 (enExample) 2004-07-22

Family

ID=10779431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8531337A Withdrawn JPH11511113A (ja) 1995-08-18 1996-08-19 シクロプロピルインドール類およびそのセコ前駆体、ならびにプロドラッグとしてのこれらの使用

Country Status (8)

Country Link
US (1) US5985909A (enExample)
EP (1) EP0850220A1 (enExample)
JP (1) JPH11511113A (enExample)
AU (1) AU707644B2 (enExample)
CA (1) CA2229264A1 (enExample)
GB (1) GB9516943D0 (enExample)
NZ (1) NZ315410A (enExample)
WO (1) WO1997007097A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011101A2 (en) * 1996-09-12 1998-03-19 Cancer Research Campaign Technology Limited Condensed n-aclyindoles as antitumor agents
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
GB9712370D0 (en) * 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DK1193270T3 (da) 1998-08-27 2003-09-15 Spirogen Ltd Pyrrolobenzodiazepiner
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
KR20110025885A (ko) 2002-07-15 2011-03-11 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
US8003625B2 (en) 2005-06-29 2011-08-23 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
BRPI0707426A2 (pt) * 2006-02-02 2011-05-03 Syntarga Bv composto, conjugado, uso de um composto, composição farmacêutica, processo para preparar uma composição farmacêutica, e, métodos de tratamento de um mamìfero estando em necessidade do mesmo, e de tratamento ou prevenção de um tumor em um mamìfero
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
ES2884044T3 (es) * 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
BRPI0820298A8 (pt) 2007-11-09 2018-05-08 Affitech Res As composições e métodos de anticorpos anti-vegf
PE20091445A1 (es) * 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
JP6387391B2 (ja) 2013-03-14 2018-09-05 ノバルティス アーゲー 眼科疾患の処置に有用な補体因子B阻害剤としての2−(1H−インドール−4−イルメチル)−3H−イミダゾ[4,5−b]ピリジン−6−カルボニトリル誘導体
EP3089963A1 (en) 2013-10-30 2016-11-09 Novartis AG 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof
EP3092010B1 (en) 2014-01-10 2018-07-11 Synthon Biopharmaceuticals B.V. Method for purifying cys-linked antibody-drug conjugates
US12036286B2 (en) 2021-03-18 2024-07-16 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988004659A2 (en) * 1986-12-19 1988-06-30 The Upjohn Company Novel cc-1065 analogs
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
WO1991016324A1 (en) * 1990-04-25 1991-10-31 The Upjohn Company Novel cc-1065 analogs
US5633158A (en) * 1991-10-23 1997-05-27 Cancer Research Campaign Technology Limited Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
NZ240785A (en) * 1991-11-28 1995-08-28 Cancer Res Campaign Tech Substituted nitro aniline derivatives and medicaments
GB9314960D0 (en) * 1992-07-23 1993-09-01 Zeneca Ltd Chemical compounds
GB9323008D0 (en) * 1993-11-05 1994-01-05 Connors Thomas Improvements relating to cancer therapy

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