JPH11507281A - Coating film - Google Patents
Coating filmInfo
- Publication number
- JPH11507281A JPH11507281A JP9502465A JP50246597A JPH11507281A JP H11507281 A JPH11507281 A JP H11507281A JP 9502465 A JP9502465 A JP 9502465A JP 50246597 A JP50246597 A JP 50246597A JP H11507281 A JPH11507281 A JP H11507281A
- Authority
- JP
- Japan
- Prior art keywords
- coating
- bone
- coating film
- tissue
- fixed support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 95
- 239000011248 coating agent Substances 0.000 title claims abstract description 91
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 92
- 239000000463 material Substances 0.000 claims abstract description 30
- 102000008186 Collagen Human genes 0.000 claims abstract description 24
- 108010035532 Collagen Proteins 0.000 claims abstract description 24
- 229920001436 collagen Polymers 0.000 claims abstract description 24
- 210000001519 tissue Anatomy 0.000 claims abstract description 20
- 239000012528 membrane Substances 0.000 claims abstract description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 5
- 210000004872 soft tissue Anatomy 0.000 claims description 41
- 239000000126 substance Substances 0.000 claims description 9
- 230000000877 morphologic effect Effects 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- 230000000704 physical effect Effects 0.000 claims description 2
- 230000002188 osteogenic effect Effects 0.000 abstract description 7
- 239000007779 soft material Substances 0.000 abstract 2
- 238000004873 anchoring Methods 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 24
- 238000010521 absorption reaction Methods 0.000 description 15
- 210000002808 connective tissue Anatomy 0.000 description 14
- 239000000316 bone substitute Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000008595 infiltration Effects 0.000 description 7
- 238000001764 infiltration Methods 0.000 description 7
- 210000004379 membrane Anatomy 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 239000011247 coating layer Substances 0.000 description 4
- 238000002485 combustion reaction Methods 0.000 description 4
- 239000007943 implant Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000003479 dental cement Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- -1 polytetrafluoroethylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
- A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
- A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30971—Laminates, i.e. layered products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0026—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in surface structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
(57)【要約】 人体に適合し、或いは特に粒状のハイドロキシアパタイトなどの、骨形成材で塞がれた人体組織の窪みを一時的に覆う、少なくとも部分的に吸収可能な材料から成る被覆膜(18)であり、柔軟材及び/または骨組織の面した被覆膜の側面が被覆膜(18)の柔軟材またはコラーゲン構造の固定を良好にする固定手段を有する。 (57) Abstract: A coating consisting of an at least partially resorbable material that is adapted to the human body or temporarily covers hollows of human tissue that are occluded with osteogenic material, such as, in particular, granular hydroxyapatite. The membrane (18), the side of the covering facing the soft material and / or the bone tissue has anchoring means for good fixation of the soft material or collagen structure of the covering (18).
Description
【発明の詳細な説明】 被覆膜 本発明は人体に適合し、場合によって、特に水酸アパタイト粒などの人体特有 の骨組織の窪みを埋める骨構成材によって一時的に被覆する、少なくとも部分的 に吸収可能な被膜材から成る被覆膜に関する。 骨及び歯科学、例えば形成外科または顎の外科手術での骨の復元などにおいて 、窪みを形成した隙間または固有の人体骨組織の孔を、通常は粒状のハイドロア パタイトの様な、骨代用材と人体骨粒子または、骨代用材のみまたは、骨粒子の 混合物の、人体骨粒から成る骨形成材によって、塞ぐことが一般的である。骨形 成材は骨の再形成によって代用されるまで、単に骨側から本質的に骨浸透される が、粘液性の膜の下に位置する結合組織によって望ましくない浸透が行われない ことを確実にするため、現在まで否骨組織から成る窪みができている(原文のま ま)。単に骨形成材の完全な骨浸透を確実にさせる時、すなわち骨の隙間が本質 的に完全に取り除かれ、骨浸透後に固有の骨形成材で形成され得る。その結果と して、一方で一つまたは複数の骨隙間のある骨は修復され、他方で歯の根底の表 面上のセメントと、隙間の下にある健康的な骨組織から成る骨の柔軟材の新しい 構成によって、骨組織が生成される。この手段は同時に骨外科に用いられ得る。 欧州特許第0 475 477 号は前文概要に被覆膜を開示しており、被覆膜は実際、 本質的に完全な吸収が可能であるが、被覆膜の吸収が非常に早くなり、骨代用材 の骨浸透及び、それによる骨隙間、欠落した骨組織または、歯用セメントの治療 手段が不利な状況で、人体とは無関係な組織の個々の吸収に伴う燃焼過程によっ て妨害され得る、という可能性がある。 不利な状況で同様な問題がある類似の被覆膜は、欧州特許第0 082 621 号び国 際特許第90/01955号に開示されている。 米国特許第4,816,339 号には多層の被覆膜が示されており、その層は吸収可能 な被覆層ではなく、ポリテトラフルオロエチレンを含む材料から成る。多層構造 はそれによって最適な成長する特性を維持しているが、膜材の吸収能力の不足は 吸収に長時間を要するという問題がある。 ドイツ公開明細書第43 02 708 号はこの種の技術分野に関する被覆膜が開示さ れており、骨代用材の骨浸透とそれによる、骨隙間の治療は、身体とは無関係の 組織の個々の吸収に伴う燃焼プロセスによって本質的に妨害されないことを更に 確実にしており、その際、膜材が人骨側からよりも、固有の人骨と逆側からより 早く吸収され得る。 この種の技術分野に関する被覆膜は確実に実証されている。しかし、早期に被 覆膜に成る可能性のある骨隙間を囲む柔軟または個々の、結合組織を望ましい位 置に備えられ、柔軟組織と後に修復される骨との間の結合を確実にする。被覆膜 が体内に残るべき時、特別ではあるが除くことは重要である。 本発明はこの種の技術分野に関する被覆膜を、欠点がなく、相対的に動きのな い骨隙間を覆う骨浸透組織粒から成る柔軟な組織または個々の、コラーゲン構造 がの安定した結合が侵出後、骨隙間を骨から成る浸透粒組織で塞ぎ、そして被覆 膜を確実にする効果的な改善ことを課題にしている。 前記課題は本発明に関して、柔軟組織に面した被覆膜側及び/または骨組織に 面した被覆膜側が(両方)柔軟な組織または、個々の被覆膜の(個々の)コラー ゲン構造の固定を向上させる固定支持手段を成すことによって解決される。 また本発明は(個々の)少なくとも一つ機械的な固定支持手段から成る(複数 の)固定支持手段を備える。 本発明では更に、機械的に動作する固定支持手段が少なくとも部分的に柔軟な 組織及び/またはコラーゲン構造によって確実に包まれるように形成される。 また本発明に関して、機械的固定支持手段は少なくとも部分的に、被覆手段で ある被覆膜の突起及び/または窪みによって形成される。 本発明ではまた、機械的固定支持手段が少なくとも部分的に、被覆手段である 被覆膜の不均一な表面によって形成されている。 本発明ではまた、固定支持手段が、柔軟な組織または、個々の骨組織に面する 被覆手段における被覆膜の表面の組織そして/またはファブリックのような構造 が、少なくとも部分的に形成される。 また、本発明は、固定支持手段は(原文のまま)柔軟組織または、個々の骨組 織に面する被覆膜の範囲で、化学的構成物及び/または被覆膜材の形態組成物を 適当に選択をすることによって、少なくとも部分的に形成されている。 本発明はまた、異なった構造及び/または組成の少なくとも二つの層を有する ことを特徴としており、柔軟組織側の層は固定支持手段から成る(原文のまま) 。 また本発明は、開いた微孔隙が柔軟組織側の層及び/または骨組織側の層に備 えられることを特徴としている。 最後に、本発明は柔軟組織側の範囲及び/または骨組織側の範囲に備えられる 柔軟組織または、個々にコラーゲン構造の化学的及び/または物理的な結合動作 を補助することを特徴とする。 本発明は驚くべき知識を基にしており、骨隙間に塗られる、結合組織または、 柔軟組織または、コラーゲン構造の粘着性を効果的に促進させることに成功して いる。その際、柔軟組織または、結合組織または、骨隙間側の被覆膜の表面は、 固定支持手段が個々の組織または、個々のコラーゲン構造の粘着力を改良するよ うに形成され、結果的に信頼性のある安定した被覆膜との結合が確実になる。例 えば、それらは、柔軟な組織または、別の結合組織ま たは、別のコラーゲン構造によって好ましく確実に覆う機械的動作手段に関わる 問題である。 更にまたはその代わりに、化学的、言い換えればまた分子的作用の結合補助手 段が備えられ得、その結合補助手段は効果的に、例えば結合組織に面する被覆膜 の対応する特殊な「特別層」によって、形成される。被覆膜は、その様な多層を 形成した結果、成長する組織または個々に、対応するコラーゲン構造と特に良好 な結合を確実にするように、結合組織に面する層または別の骨隙間を、最善の状 態にすることが可能である。基層は特に良好なセル閉鎖性、分子閉塞性及び/ま たは機械的支持効果をもたらすように、形成され得る。 前記の事柄はどの場合でも本質的なことであり、柔軟組織または、個々の骨組 織側の表面に対応する形成、例えば構成は結合組織から成るコラーゲン構造が成 長することで可能になる。 更に本発明の特徴と利点は以下に記載されており、実施例は添付図面を用いて 詳細に説明される。 第1図は本発明に関する被覆膜の実施例の被覆平面に対する縦断面図である。 第2図は第1図の対応した本発明に関する被覆膜の別の実施例である。 第3図は第2図に対応した本発明の被覆膜の更に別の実施例である。 第1図に図示される様に、図面上に結合組織または柔軟組織が示されており、 組織の表面に被覆膜18、突起部36及び窪み38がある。各々は上部に結合組 織のコラーゲン構造を塗ることによって、確実に覆われ得、被覆膜18の結合組 織を良好に固定する。 第2図の変形実施例では、骨側の基層40から成る被覆膜18及被覆層42が 構成され、同様にコラーゲン構造を塗る適当な前記開いた小孔44が ある。 第3図の実施例には基層40側、すなわち骨隙間側の被膜層42、同様に骨隙 間から行われるコラーゲン構造を塗る適当な前記開いた小孔44を有する裏層4 6を備える。被膜層42及び46は特にこの様な吸収手段を基にしていることは 明らかであり、歯科において吸収時間が約6〜12週間に、骨外科では吸収時間 が約6〜9カ月になる。 前記の記載、図面及び請求の範囲に開示されている、本発明の明らかな特徴を 、単独でそして任意に組み合わせて、本発明の様々な実施例を実現する本質的な ことである。DETAILED DESCRIPTION OF THE INVENTION Coating film The present invention is suitable for the human body, and in some cases, especially for the human body such as hydroxyapatite particles. Temporarily covered, at least partially, by a bone component that fills the depression in the bone tissue of the The present invention relates to a coating film made of a coating material that can be absorbed into a coating. In bone and dentistry, for example in bone reconstruction in plastic or jaw surgery Pits, or gaps in the inherent human bone tissue, usually Bone substitutes such as patite and human bone particles or bone substitutes alone or bone particles It is common to occlude the mixture with an osteogenic material consisting of human bone grains. Bone shape The wood is essentially penetrated from the bone side until it is replaced by bone remodeling But no undesired penetration by connective tissue underlying the mucous membrane To ensure this, there has been a depression made of boneless tissue to date. H). Simply to ensure complete bone penetration of osteogenic material, i.e. bone gaps are essential Can be completely removed and formed of native bone forming material after bone infiltration. The result and The bone with one or more bone gaps is repaired on the one hand and the underlying surface of the tooth on the other hand A new bone softener consisting of cement on the surface and healthy bone tissue underneath the gap Depending on the configuration, bone tissue is generated. This means can be used simultaneously for bone surgery. EP 0 475 477 discloses a coating in the preamble summary, which is in fact Essentially complete absorption is possible, but the absorption of the coating is very fast, and bone substitute Infiltration of bones and thereby treatment of bone gaps, missing bone tissue or dental cement In an unfavorable situation, the combustion process associated with the individual absorption of tissue unrelated to the human body Could be disturbed. Similar coatings, which have similar problems in disadvantageous situations, are described in EP 0 082 621 International Patent No. 90/01955. U.S. Pat.No. 4,816,339 shows a multi-layer coating that is absorbable It is made of a material containing polytetrafluoroethylene instead of a simple coating layer. Multi-layer structure Maintains optimal growth characteristics, but lacks the absorption capacity of the membrane material. There is a problem that it takes a long time for absorption. German Offenlegungsschrift 43 02 708 discloses a coating for this type of technical field. The bone infiltration of bone substitutes and thus the treatment of bone gaps is independent of the body. Furthermore that it is essentially unhindered by the combustion processes associated with the individual absorption of tissue In that the membrane material is more from the side opposite the native bone than from the human bone side Can be absorbed quickly. Coatings for this type of technical field have been proven with certainty. However, early The flexible or individual connective tissue surrounding the interstitial bone gap that may become a covering In place to ensure a bond between the soft tissue and the bone to be repaired later. Coating film When they should remain in the body, it is special but important to remove them. The present invention provides a coating film for this type of technical field which has no disadvantages and is relatively immobile. Soft tissue consisting of bone-penetrating tissue grains covering individual bone gaps or individual collagen structures After the stable bond has been leached, the bone gap is closed with infiltrated granular tissue consisting of bone and covered The challenge is to improve the film effectively. According to the present invention, the object is to provide a coating film facing soft tissue and / or bone tissue. Flexible tissue on both sides (both) or the (individual) collar of the individual coating The problem is solved by providing fixing support means for improving the fixing of the gen structure. The invention also comprises at least one (individual) mechanical fixed support means (multiple). A) fixed support means. The invention further provides that the mechanically operated fixed support means is at least partially flexible. It is formed to be securely enveloped by the tissue and / or collagen structure. Also in the context of the present invention, the mechanically fixed support means is at least partially provided by a covering means. It is formed by protrusions and / or depressions of a coating film. The invention also provides that the mechanical fixed support means is, at least in part, a coating means. It is formed by the uneven surface of the coating film. The invention also provides that the fixed support means faces soft tissue or individual bone tissue Texture and / or fabric-like structure on the surface of the coating in the coating means Is at least partially formed. The present invention also provides that the fixed support means is a soft tissue (as is) or an individual skeleton. In the area of the coating facing the weave, the chemical composition and / or the morphological composition of the coating It is at least partially formed by appropriate choices. The invention also has at least two layers of different structure and / or composition Characterized in that the layer on the soft tissue side comprises a fixed support means (as is) . The invention also provides that the open micropores are provided in the layer on the soft tissue side and / or the layer on the bone tissue side. It is characterized by being obtained. Finally, the invention is provided in the area of soft tissue and / or in the area of bone tissue. Chemical and / or physical bonding of soft tissue or individual collagen structures It is characterized by assisting. The present invention is based on surprising knowledge and applies connective tissue or Successfully promotes the adhesion of soft tissue or collagen structures I have. At that time, the soft tissue or connective tissue or the surface of the coating film on the bone gap side, Fixed support means improve the adhesion of individual tissues or individual collagen structures. And a reliable and stable bond with the coating is assured. An example For example, they can be flexible tissue or another connective tissue. Or means of mechanical actuation, preferably and securely covered by another collagen structure It is a problem. Additionally or alternatively, a chemical, or in other words, also a molecular aid binding aid A step may be provided, the binding aid of which is effective, for example, a coating membrane facing the connective tissue. Is formed by a corresponding special layer. The coating film has such a multilayer. As a result of formation, growing tissues or individually, especially good with the corresponding collagen structure The layers facing the connective tissue or other bone gaps should be optimally It is possible to state. The base layer has particularly good cell closure, molecular closure and / or Or it can be shaped to provide a mechanical support effect. The above is essential in any case, whether the soft tissue or the individual skeleton The formation corresponding to the weave-side surface, for example, a collagen structure consisting of connective tissue It becomes possible by lengthening. Further features and advantages of the present invention are described below, examples of which are illustrated in the accompanying drawings. This will be described in detail. FIG. 1 is a longitudinal sectional view of an embodiment of a coating film according to the present invention with respect to a coating plane. FIG. 2 shows another embodiment of the coating film according to the present invention corresponding to FIG. FIG. 3 shows still another embodiment of the coating film of the present invention corresponding to FIG. As shown in FIG. 1, connective or soft tissue is shown on the drawing, On the surface of the tissue there is a coating 18, a projection 36 and a depression 38. Each is joined at the top By coating the woven collagen structure, it can be surely covered, Weaves well. In the variant shown in FIG. 2, the covering layer 18 and the covering layer 42 comprising the bone-side base layer 40 are provided. A suitable said open stoma 44, which is also constructed and paints a collagen structure, is there. In the embodiment of FIG. 3, the coating layer 42 on the side of the base layer 40, that is, on the side of the bone gap, Back layer 4 with appropriate open pores 44 for painting collagen structure made therefrom 6 is provided. It is noted that the coating layers 42 and 46 are based in particular on such absorption means. It is clear that the absorption time is about 6-12 weeks in dentistry and the absorption time in bone surgery. About 6 to 9 months. BRIEF DESCRIPTION OF THE DRAWINGS The obvious features of the invention disclosed in the foregoing description, drawings and claims. , Alone and in any combination, realize the various embodiments of the present invention. That is.
【手続補正書】特許法第184条の8第1項 【提出日】1997年5月26日 【補正内容】 明細書 被覆膜 本発明は身体に適合し、場合によって、特に水酸アパタイト粒などの人体特有 の骨組織の窪みを埋める骨形成材によって一時的に被覆する、少なくとも部分的 に吸収可能な被膜材から成る被覆膜に関する。 柔軟組織側の被覆材の側面及び/または骨組織側の被覆材の側面が、柔軟組織 または、個々の被覆材のコラーゲン構造の固定を改善する固定支持手段から成り 、固定支持手段は少なくとも一つの機械的固定補助手段を有する。 骨及び歯科学、例えば形成外科または顎の外科手術での骨の復元など、におい て、窪みを形成した隙間または固有の身体骨組織の孔を、通常は粒状のハイドロ アパタイトの様な、骨の代用材と人体骨粒子または、骨代用材または骨粒子のみ の混合物の、人体骨粒から成る骨の成分を含む材料によって、塞ぐことが一般的 である。骨の成分を含む材料は骨形成材によって用されるまで、単に骨側から本 質的に骨浸透されるが、粘液性の膜の下に位置する結合組織によって望ましくな い浸透が行われないことを確実にするため、現在まで否骨組織から成る窪みがで きている(原文のまま)。単に骨形成材の完全な骨浸透を確実にさせる時、すな わち骨の隙間が本質的に完全に取り除かれ、骨浸透後に固有の骨形成材で再形成 され得る。その結果として、一方で一つまたは複数の骨隙間のある骨は修復され 、他方で歯の根底の表面上のセメントと、隙間の下にある健康的な骨組織から成 る骨の柔軟材の新しい構成によって、骨組織が生成される。この手段は同時に骨 外科に用いられ得る。 欧州特許第0 475 477号は前文概要に被覆膜を開示しており、被覆膜は実際、 本質的に完全な吸収が可能であるが、被覆膜の吸収が非常に早くなり、骨代用材 の骨浸透及び、それによる骨隙間、欠落した骨組織または、歯用セメントの治療 手段が不利な状況で、人体とは無関係な組織の個々の吸収に伴 う燃焼過程によって妨害され得る、という可能性がある。 不利な状況で同様な問題がある類似の被覆膜は、欧州特許第0 082 621号及び 国際特許第90/01955号に開示されている。 米国特許第4,816,339号には多層の被覆膜が示されており、その層は吸収可能 な被覆層ではなく、ポリテトラフルオロエチレンを含む材料から成る。多層構造 はそれによって最適な成長する特性を維持しているが、膜材の吸収能力の不足は 吸収に長時間を要するという問題がある。 ドイツ公開明細書第43 02 708号はこの種の技術分野に関する被覆膜が開示さ れており、骨代用材の骨浸透とそれによる、骨隙間の治療は、身体とは無関係の 組織の個々の吸収に伴う燃焼プロセスによって本質的に妨害されないことを更に 確実にしており、その際、膜材が人骨側からよりも、固有の人骨と逆側からより 早く吸収され得る。 国際特許第95/09583号にはインプラントが開示されており、抵抗及び、骨組織 に成長する状況での良好な粘着力を特に重要としている。これは孔の端部の高さ と協同して、インプラントと新しい骨組織との間のせん断力に対する特別高い抵 抗を提供する、好ましい表面によって達成される。3ページに示されたように、 ここで論じられ記載された第1段落で、重要なことは主にインプラントが成長し ない状況で良好に安定して配置されていたことである。 この種の技術分野に関する被覆膜は確実に実証されている。しかし、骨隙間を 早期に成長する被覆膜で覆う可能性のある柔軟または結合組織が望ましく備えら れ、柔軟組織と後に修復される骨との間の良好な結合を確実にする。被覆膜が体 内に残るべき時、特別ではあるが除くことは重要である。 本発明の基本的な目的は、柔軟組織の欠点のなく、相対的に動きかない安定し た結合をすることまたは、骨隙間への侵出後に、骨隙間を骨に似た予め 粒状の組織で塞ぐコラーゲン構造を提供することを基に被覆膜を改善し、そして 被覆膜を確実にすることである。 前記目的は、被覆膜が形成される時に、機械動作式固定補助手段が少なくとも 部分的に、柔軟材及び/またはコラーゲン構造によって効果的に覆われる様に、 形成されることで達成される。 また本発明に関して、機械固定手段が少なくとも部分的に、被覆手段の被覆膜 の突起部及び/または窪みによって形成されている。 本発明ではまた、機械的固定支持手段が少なくとも部分的に、被覆手段である 被覆膜の不均一な表面によって形成されている。 本発明ではまた、固定支持手段が、柔軟な組織または、個々の骨組織に面する 被覆手段における被覆膜の表面の組織そして/またはファブリックのような構造 が、少なくとも部分的に形成される。 また、本発明は、固定支持手段は(原文のまま)柔軟組織または、個々の骨組 織に面する被覆膜の範囲で、化学的構成物及び/または被覆膜材の形態組成物を 適当に選択をすることによって、少なくとも部分的に形成されている。 本発明はまた、異なった構造及び/または組成の少なくとも二つの層を有する ことを特徴としており、柔軟組織側の層は固定支持手段から成る(原文のまま) 。 また本発明は、開いた微孔隙が柔軟組織側の層及び/または骨組織側の層に備 えられることを特徴としている。 最後に、本発明は柔軟組織側の範囲及び/または骨組織側の範囲に備えられる 柔軟組織または、個々にコラーゲン構造の化学的及び/または物理的な結合動作 を補助することを特徴とする。 本発明は驚くべき知識を基にしており、骨隙間に塗られる、結合組織また は、柔軟組織または、コラーゲン構造の粘着性を効果的に促進させることに成功 している。その際、柔軟組織または、結合組織または、骨隙間側の被覆膜の表面 は、固定支持手段が個々の組織または、個々のコラーゲン構造の粘着力を改良す るように形成され、結果的に信頼性のある安定した被覆膜との結合が確実になる 。例えば、それらは、柔軟な組織または、別の結合組織ま 請求の範囲 1.人体に適合し、或いは一時的に特にハイドロキシアパタイト粒などの、骨形 成材で塞がれた固有の人骨組織の窪みを覆う、少なくとも部分的に吸収可能な被 膜材、から成る被覆材であり、 被覆材(18)が柔軟組織側に、及び/または被覆材(18)が骨組織側に配置 し、 被覆材(18)の柔軟組織または(個々の)コラーゲン構造の固定を良好にする 個々の固定支持手段(36、38、42、44、46)を備え、 固定支持手段が(個々に)少なくとも一つの機械補助手段(36、38)から成 り、機械的に作動する固定補助手段(36、38)が少なくとも部分的に、柔軟 組織及び/またはコラーゲン構造によって効果的に覆われる形成されることを特 徴とする被覆膜。 2.膜材が少なくとも部分的に吸収可能であることを特徴とする請求の範囲1に 記載の被覆膜。 3.機械的固定支持手段は少なくとも部分的に、被覆手段である被覆膜(18) の突起部(36)及び/または窪み(38)によって、形成されることを特徴と する請求の範囲2または3のいずれか一つに記載の被覆膜。 4.機械的固定支持手段が少なくとも部分的に、被覆手段である被覆膜(18) の平面が不均一に形成されることを特徴とする請求の範囲2〜4のいずれか一つ に記載の被覆膜。 5.機械的固定手段が少なくとも部分的に、被覆手段である被覆膜(18)の柔 軟組織または骨組織に面した平面を有する、組織及び/またはファブリック状構 造を形成することを特徴とする請求の範囲2〜5に記載の被覆膜。 6.固定支持手段が少なくとも部分的に、被覆膜(18)の柔軟組織または 骨組織に面した範囲(42)において、被覆膜(18)の材料の化学的結合及び /または形態学的構造の適当な選択によって、形成されることを特徴とする請求 の範囲1〜6のいずれか一つに記載の被覆膜。 7.異なる構造及び/または結合の少なくとも二つの層(40、42、46)で あり、柔軟組織側の層(42)及び/または骨組織に面する層(46)が固定支 持手段(44)から成ることを特徴とする請求の範囲1〜7のいずれか一つに記 載の被覆膜。 8.開いた小孔が、柔軟組織及び/または骨組織に面した層(42、46)に配 置されていることを特徴とする請求の範囲8に記載の被覆膜。 9.柔軟組織及び/または骨組織に面した範囲で、柔軟組織または個々のコラー ゲン構造の、化学的及び/または物理的作用の分子結合をすることを特徴とする 請求の範囲1〜9のいずれか一つに記載の被覆膜。[Procedure of Amendment] Article 184-8, Paragraph 1 of the Patent Act [Submission date] May 26, 1997 [Correction contents] Specification Coating film The invention is adaptable to the body and, in some cases, especially human-specific, such as hydroxyapatite granules At least partially covered with osteogenic material that fills the depressions in the bone tissue of the The present invention relates to a coating film made of a coating material that can be absorbed into a coating. The side of the dressing on the soft tissue side and / or the side of the dressing on the bone tissue side Alternatively, it comprises fixed support means to improve the fixation of the collagen structure of the individual dressings. The fixing support means has at least one mechanical fixing auxiliary means. Smell in bone and dentistry, e.g. bone reconstruction in plastic or jaw surgery The creviced gaps or holes in the unique body bone tissue, usually with granular hydro Bone substitutes and human bone particles, such as apatite, or bone substitutes or bone particles only It is common to block with a mixture of It is. The material containing the components of the bone is simply booked from the bone side until used by the osteogenic material. Qualitatively penetrates bone, but is undesirable by the connective tissue underlying the mucous membrane In order to ensure that no infiltration takes place, there is a hollow Is coming (as is). Simply to ensure complete bone penetration of the osteogenic material, In essence, the bone gap has been essentially completely removed and, after bone infiltration, reformed with native osteogenic material Can be done. As a result, bone with one or more bone gaps on the other hand is repaired On the other hand, the cement on the underlying surface of the tooth and the healthy bone tissue underneath the gap A new configuration of bone softener produces bone tissue. This means that the bones Can be used for surgery. EP 0 475 477 discloses a coating in the preamble summary, wherein the coating is in fact Essentially complete absorption is possible, but the absorption of the coating is very fast, and bone substitute Infiltration of bones and thereby treatment of bone gaps, missing bone tissue or dental cement In a situation where means are disadvantageous, individual absorption of tissues unrelated to the human body Could be hindered by the combustion process. Similar coatings, which have similar problems in disadvantageous situations, are described in EP 0 082 621 and It is disclosed in WO 90/01955. U.S. Pat.No. 4,816,339 shows a multi-layer coating that is absorbable It is made of a material containing polytetrafluoroethylene instead of a simple coating layer. Multi-layer structure Maintains optimal growth characteristics, but lacks the absorption capacity of the membrane material. There is a problem that it takes a long time for absorption. German Offenlegungsschrift 43 02 708 discloses a coating for this type of technical field. The bone infiltration of bone substitutes and thus the treatment of bone gaps is independent of the body. Furthermore that it is essentially unhindered by the combustion processes associated with the individual absorption of tissue In that the membrane material is more from the side opposite the native bone than from the human bone side Can be absorbed quickly. International Patent No. 95/09583 discloses an implant, which provides resistance and bone tissue Good adhesion is particularly important in growing conditions. This is the height of the end of the hole In combination with the extra high resistance to shear forces between the implant and the new bone tissue Achieved by a preferred surface that provides resistance. As shown on page 3, In the first paragraph discussed and described here, the important thing is mainly that the implant grows It was a good and stable arrangement in no situation. Coatings for this type of technical field have been proven with certainty. But the bone gap Flexible or connective tissue that may be covered by an early growing coating To ensure a good connection between the soft tissue and the bone that is to be repaired later. Coating film is body It is special, but important to exclude when it should remain within. The basic object of the present invention is to provide a stable and relatively immobile body without the disadvantages of soft tissue. After making a joint or extruding into the bone gap, the bone gap is Improve the coating based on providing a collagen structure that plugs with granular tissue, and The purpose is to ensure a coating film. The object is that when the coating film is formed, at least the mechanically operated fixing auxiliary means is provided. In part, so that it is effectively covered by the softener and / or collagen structure, It is achieved by being formed. Also in connection with the present invention, the mechanical fastening means is at least partially provided by And / or recesses. The invention also provides that the mechanical fixed support means is, at least in part, a coating means. It is formed by the uneven surface of the coating film. The invention also provides that the fixed support means faces soft tissue or individual bone tissue Texture and / or fabric-like structure on the surface of the coating in the coating means Is at least partially formed. The present invention also provides that the fixed support means is a soft tissue (as is) or an individual skeleton. In the area of the coating facing the weave, the chemical composition and / or the morphological composition of the coating It is at least partially formed by appropriate choices. The invention also has at least two layers of different structure and / or composition Characterized in that the layer on the soft tissue side comprises a fixed support means (as is) . The invention also provides that the open micropores are provided in the layer on the soft tissue side and / or the layer on the bone tissue side. It is characterized by being obtained. Finally, the invention is provided in the area of soft tissue and / or in the area of bone tissue. Chemical and / or physical bonding of soft tissue or individual collagen structures It is characterized by assisting. The present invention is based on surprising knowledge, and applies connective tissue or Successfully promotes the adhesion of soft tissue or collagen structures doing. At this time, the surface of the soft tissue or connective tissue or the coating film on the bone gap side The fixation support means improves the adhesion of individual tissues or individual collagen structures. To ensure a reliable and stable bond to the coating . For example, they can be flexible tissue or another connective tissue. The scope of the claims 1. Bone forms, such as those that fit or temporarily fit the human body, especially hydroxyapatite granules At least partially resorbable material covering the natural human bone tissue depression closed by the material A coating material comprising a film material; The dressing (18) is placed on the soft tissue side and / or the dressing (18) is placed on the bone tissue side And Good fixation of the soft tissue or (individual) collagen structure of the dressing (18) Individual fixed support means (36, 38, 42, 44, 46); The fixed support means comprises (individually) at least one mechanical auxiliary means (36, 38). The mechanically actuated securing aids (36, 38) are at least partially flexible. It is characterized by being effectively covered by tissue and / or collagen structures. Characteristic coating film. 2. 2. The method according to claim 1, wherein the film material is at least partially absorbable. A coating film as described in the above. 3. A coating film (18), wherein the mechanical fixed support means is at least partially a coating means; Formed by the projections (36) and / or depressions (38) of The coating film according to any one of claims 2 and 3, wherein 4. Coating membrane (18), wherein the mechanically fixed support means is at least partially a coating means Wherein the flat surface is formed non-uniformly. 3. The coating film according to item 1. 5. The mechanical fixing means is at least partially provided for the softening of the coating film (18) which is the coating means. Tissue and / or fabric-like structure having a flat surface facing soft or bone tissue The coating according to any one of claims 2 to 5, wherein the coating is formed. 6. The fixed support means is at least partially provided by the soft tissue or In the area (42) facing the bone tissue, the chemical bonding of the material of the coating (18) and And / or formed by a suitable choice of morphological structure. The coating film according to any one of ranges 1 to 6. 7. With at least two layers (40, 42, 46) of different structures and / or bonds The soft tissue side layer (42) and / or the bone tissue facing layer (46) And holding means (44). Coating film. 8. Open ostia are arranged in the layers (42, 46) facing the soft and / or bone tissue. The coating film according to claim 8, wherein the coating film is disposed. 9. Soft tissue or individual collagen to the extent facing soft tissue and / or bone tissue Characterized by the chemical and / or physical action of molecular bonding A coating film according to any one of claims 1 to 9.
───────────────────────────────────────────────────── フロントページの続き (81)指定国 EP(AT,BE,CH,DE, DK,ES,FI,FR,GB,GR,IE,IT,L U,MC,NL,PT,SE),OA(BF,BJ,CF ,CG,CI,CM,GA,GN,ML,MR,NE, SN,TD,TG),AP(KE,LS,MW,SD,S Z,UG),UA(AM,AZ,BY,KG,KZ,MD ,RU,TJ,TM),AL,AM,AT,AU,AZ ,BB,BG,BR,BY,CA,CH,CN,CZ, DK,EE,ES,FI,GB,GE,HU,IS,J P,KE,KG,KP,KR,KZ,LK,LR,LS ,LT,LU,LV,MD,MG,MK,MN,MW, MX,NO,NZ,PL,PT,RO,RU,SD,S E,SG,SI,SK,TJ,TM,TR,TT,UA ,UG,US,UZ,VN────────────────────────────────────────────────── ─── Continuation of front page (81) Designated countries EP (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, L U, MC, NL, PT, SE), OA (BF, BJ, CF) , CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG), AP (KE, LS, MW, SD, S Z, UG), UA (AM, AZ, BY, KG, KZ, MD , RU, TJ, TM), AL, AM, AT, AU, AZ , BB, BG, BR, BY, CA, CH, CN, CZ, DK, EE, ES, FI, GB, GE, HU, IS, J P, KE, KG, KP, KR, KZ, LK, LR, LS , LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, S E, SG, SI, SK, TJ, TM, TR, TT, UA , UG, US, UZ, VN
Claims (1)
Applications Claiming Priority (3)
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DE19520867A DE19520867C2 (en) | 1995-06-08 | 1995-06-08 | Covering membrane |
DE19520867.6 | 1995-06-08 | ||
PCT/DE1996/000630 WO1996041594A1 (en) | 1995-06-08 | 1996-04-03 | Cover diaphragm |
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JPH11507281A true JPH11507281A (en) | 1999-06-29 |
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JP9502465A Pending JPH11507281A (en) | 1995-06-08 | 1996-04-03 | Coating film |
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EP (1) | EP0830115A1 (en) |
JP (1) | JPH11507281A (en) |
KR (1) | KR100250116B1 (en) |
AU (1) | AU700349B2 (en) |
BR (1) | BR9609157A (en) |
CA (1) | CA2217036A1 (en) |
DE (1) | DE19520867C2 (en) |
HU (1) | HUP9802830A3 (en) |
WO (1) | WO1996041594A1 (en) |
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DE19835251A1 (en) | 1998-07-10 | 2000-03-23 | Eckhard Binder | Molded parts, especially foils, to promote the new formation of bone material in the jaw |
WO2001006949A2 (en) * | 1999-07-28 | 2001-02-01 | Interface Biotech A/S | In vitro repair of bone and/or cartilage defects |
DE19940977A1 (en) * | 1999-08-28 | 2001-03-01 | Lutz Claes | Film of resorbable polymer material and process for producing such a film |
JP2003516803A (en) | 1999-12-15 | 2003-05-20 | ズルツァー・オルトペディクス・リミテッド | Device for repairing cartilage defects or cartilage / bone defects in human or animal joints |
DE102007050440A1 (en) * | 2007-10-18 | 2009-04-23 | Alexakis, Antonis, Dr. med. dent. | Coated granules for the regeneration of bone material |
DE102009020707A1 (en) * | 2009-05-11 | 2010-11-25 | Alexakis, Antonis, Dr. med. dent. | Coated granules for the regeneration of bone material |
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US4629464A (en) * | 1984-09-25 | 1986-12-16 | Tdk Corporation | Porous hydroxyapatite material for artificial bone substitute |
GB8524823D0 (en) * | 1985-10-08 | 1985-11-13 | Finsbury Instr Ltd | Orthopaedic implants |
US4816339A (en) * | 1987-04-28 | 1989-03-28 | Baxter International Inc. | Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation |
US4865603A (en) * | 1988-02-04 | 1989-09-12 | Joint Medical Products Corporation | Metallic prosthetic devices having micro-textured outer surfaces |
US5152791A (en) * | 1989-12-07 | 1992-10-06 | Olympus Optical Co., Ltd. | Prosthetic artificial bone having ceramic layers of different porosity |
ATE139126T1 (en) * | 1990-09-10 | 1996-06-15 | Synthes Ag | MEMBRANE FOR BONE REGENERATION |
CA2094908C (en) * | 1990-12-06 | 2000-02-08 | Byron Kent Hayes | Implantable bioabsorbable article |
CA2033107C (en) * | 1990-12-24 | 2001-06-12 | Robert Edward Burrell | Actively sterile surfaces |
DE4211343A1 (en) * | 1992-04-04 | 1993-10-07 | S & G Implants Gmbh | Endoprosthesis - has cladding of osteo-inductive material at cell or pore surface of metal anchor to encourage bone tissue growth for bonding with anchor |
DE4302709C1 (en) * | 1993-02-01 | 1994-07-28 | Kirsch Axel | Cover device with cover membrane |
DE4302708C2 (en) * | 1993-02-01 | 1995-06-01 | Kirsch Axel | Covering membrane |
SE504294C2 (en) * | 1993-10-01 | 1996-12-23 | Lucocer Ab | Implants intended to be fixed by contact with newly formed bone tissue |
DE4414675C1 (en) * | 1994-04-27 | 1995-09-28 | Kirsch Axel | Covering device for bone defects and method for their production |
-
1995
- 1995-06-08 DE DE19520867A patent/DE19520867C2/en not_active Expired - Fee Related
-
1996
- 1996-04-03 EP EP96909032A patent/EP0830115A1/en not_active Withdrawn
- 1996-04-03 JP JP9502465A patent/JPH11507281A/en active Pending
- 1996-04-03 AU AU52695/96A patent/AU700349B2/en not_active Ceased
- 1996-04-03 KR KR1019970709088A patent/KR100250116B1/en not_active IP Right Cessation
- 1996-04-03 CA CA002217036A patent/CA2217036A1/en not_active Abandoned
- 1996-04-03 HU HU9802830A patent/HUP9802830A3/en unknown
- 1996-04-03 BR BR9609157A patent/BR9609157A/en not_active Application Discontinuation
- 1996-04-03 WO PCT/DE1996/000630 patent/WO1996041594A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2217036A1 (en) | 1996-12-27 |
HUP9802830A3 (en) | 2000-11-28 |
DE19520867A1 (en) | 1996-12-12 |
AU700349B2 (en) | 1999-01-07 |
DE19520867C2 (en) | 1998-05-20 |
HUP9802830A2 (en) | 1999-06-28 |
WO1996041594A1 (en) | 1996-12-27 |
AU5269596A (en) | 1997-01-09 |
KR19990022607A (en) | 1999-03-25 |
KR100250116B1 (en) | 2000-06-01 |
EP0830115A1 (en) | 1998-03-25 |
BR9609157A (en) | 1999-05-04 |
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