JPH11505803A5 - - Google Patents

Info

Publication number
JPH11505803A5
JPH11505803A5 JP1996534977A JP53497796A JPH11505803A5 JP H11505803 A5 JPH11505803 A5 JP H11505803A5 JP 1996534977 A JP1996534977 A JP 1996534977A JP 53497796 A JP53497796 A JP 53497796A JP H11505803 A5 JPH11505803 A5 JP H11505803A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1996534977A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11505803A (ja
Filing date
Publication date
Priority claimed from US08/442,223 external-priority patent/US5616712A/en
Application filed filed Critical
Publication of JPH11505803A publication Critical patent/JPH11505803A/ja
Publication of JPH11505803A5 publication Critical patent/JPH11505803A5/ja
Ceased legal-status Critical Current

Links

JP8534977A 1995-05-16 1996-05-13 レチノイド様活性を有するキノリル−エチニル誘導体 Ceased JPH11505803A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/442,223 1995-05-16
US08/442,223 US5616712A (en) 1995-05-16 1995-05-16 Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity
PCT/US1996/006866 WO1996036609A1 (en) 1995-05-16 1996-05-13 Quinolyl-ethynyl derivatives having retinoid-like activity

Publications (2)

Publication Number Publication Date
JPH11505803A JPH11505803A (ja) 1999-05-25
JPH11505803A5 true JPH11505803A5 (cg-RX-API-DMAC7.html) 2004-07-08

Family

ID=23755999

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8534977A Ceased JPH11505803A (ja) 1995-05-16 1996-05-13 レチノイド様活性を有するキノリル−エチニル誘導体

Country Status (6)

Country Link
US (1) US5616712A (cg-RX-API-DMAC7.html)
EP (1) EP0825986A1 (cg-RX-API-DMAC7.html)
JP (1) JPH11505803A (cg-RX-API-DMAC7.html)
AU (1) AU705144B2 (cg-RX-API-DMAC7.html)
CA (1) CA2221131A1 (cg-RX-API-DMAC7.html)
WO (1) WO1996036609A1 (cg-RX-API-DMAC7.html)

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US5675033A (en) * 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5952345A (en) 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6218128B1 (en) 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5958954A (en) * 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6942980B1 (en) 1995-09-01 2005-09-13 Allergan, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
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US5663357A (en) * 1995-11-22 1997-09-02 Allergan Substituted heteroarylamides having retinoid-like biological activity
US20030219832A1 (en) * 1996-03-11 2003-11-27 Klein Elliott S. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6555690B2 (en) * 1996-06-21 2003-04-29 Allergan, Inc. Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5741896A (en) 1996-06-21 1998-04-21 Allergan O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5763635A (en) * 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en) * 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5760276A (en) * 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6037488A (en) * 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US5919970A (en) * 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
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US6127382A (en) * 1999-08-16 2000-10-03 Allergan Sales, Inc. Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity
US6613917B1 (en) 2000-03-23 2003-09-02 Allergan, Inc. Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity
US6313107B1 (en) * 2000-08-29 2001-11-06 Allergan Sales, Inc. Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
US6291677B1 (en) 2000-08-29 2001-09-18 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6252090B1 (en) 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
WO2003094830A2 (en) 2002-05-07 2003-11-20 Neurosearch A/S Novel azacyclic ethynyl derivatives
US6683092B1 (en) * 2003-04-09 2004-01-27 Allergan, Inc. [3-(c5-14alkyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-phenyl and [3-(c5-14alkyl-2-oxo-1,2,3,4- tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-heteroaryl derivatives having anti-tumor activity
US7098340B2 (en) * 2003-05-14 2006-08-29 Warner Lambert Company Llc Benzyl sulfonamide derivatives
US6734193B1 (en) 2003-06-03 2004-05-11 Allergan, Inc. (1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity
US8628756B2 (en) * 2005-12-30 2014-01-14 Revance Therapeutics, Inc. Arginine heteromers for topical administration
US20080113948A1 (en) 2006-08-16 2008-05-15 Action Medicines Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Psoriasis
EP2125697B1 (en) 2007-01-15 2016-09-28 Chongxi Yu Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
CN107176945B (zh) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 一种视黄酸类化合物、其制备方法、中间体及应用

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