JPH11504923A - 電気的移送式薬物投与のための製剤の製造 - Google Patents
電気的移送式薬物投与のための製剤の製造Info
- Publication number
- JPH11504923A JPH11504923A JP8533421A JP53342196A JPH11504923A JP H11504923 A JPH11504923 A JP H11504923A JP 8533421 A JP8533421 A JP 8533421A JP 53342196 A JP53342196 A JP 53342196A JP H11504923 A JPH11504923 A JP H11504923A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- solution
- therapeutic agent
- electrotransport
- reservoir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.治療剤溶液のpHを所定の望ましいpHレベルに調節することを含む、 動物の体表を通しての電気的移送系によって治療剤を投与するために適した電気 的移送式投与系に組み入れるための治療剤製剤の製造方法において、 外来イオン性物質を溶液中に実質的に導入することなく、前記pH調節をおこ なうことができる物質を治療剤と反応させることを特徴とする方法。 2.前記pH調節後に、該物質を溶液から取り出して、電気的移送式投与に 適したpH調節済み治療剤製剤を形成することを特徴とする、請求項1記載の方 法。 3.該物質の前記取り出しが溶液の濾過によって達成されることを特徴とす る、請求項2記載の方法。 4.溶液が水溶液であることを特徴とする、請求項1記載の方法。 5.治療剤が、それと会合した負に荷電した対イオンを有するカチオン薬物 を含み、該物質がアニオン交換樹脂であることを特徴とする、請求項1記載の方 法。 6.体表がヒトの皮膚であることと、pH約6〜9の範囲への溶液のpHの 調節を包含することを特徴とする、請求項5記載の方法。 7.体表がヒトの皮膚であることと、pH約7.5〜8.5の範囲への溶液 のpHの調節を包含することを特徴とする、請求項5記載の方法。 8.アニオン交換樹脂がアミン含有ポリマーの水酸化物形を含むことを特徴 とする、請求項5記載の方法。 9.アミン含有ポリマーがポリビニルアミン、ポリエピクロロヒドリン/テ トラエチレントリアミン、スチレンとジビニルベンゼンとのコポリマー、アクリ ル/ジビニルベンゼンコポリマー、及びアクリル/エチレングルコールジメタク リレートコポリマーから成る群から選択されることを特徴とする、請求項8記載 の方法。 10.治療剤が、それと会合した負に荷電した対イオンを有する多価カチオ ン薬物を含むことを特徴とする、請求項1記載の方法。 11.治療剤が、それと結合した正に荷電した対イオンを有するアニオン薬 物を含み、該物質がカチオン交換樹脂であることを特徴とする、請求項1記載の 方法。 12.体表がヒトの皮膚であることと、pH約3〜6の範囲への溶液のpH の調節を包含することを特徴とする、請求項11記載の方法。 13.体表がヒトの皮膚であることと、pH約3.5〜5の範囲への溶液の pHの調節を包含することを特徴とする、請求項11記載の方法。 14.カチオン交換樹脂が1個以上の酸部分を有するポリマーを含むことを 特徴とする、請求項11記載の方法。 15.ポリマーがポリ(アクリル酸)、ポリ(アクリルスルホン酸)、ポリ (アクリルリン酸)及びポリ(アクリルグリコール酸)から成る群から選択され ることを特徴とする、請求項14記載の方法。 16.治療剤と該物質とを、望ましいpH調節度を生じさせるために充分な 時間反応させることによって、pH調節が達成されることを特徴とする、請求項 1記載の方法。 17.治療剤が薬物であることを特徴とする、請求項1記載の方法。 18.pH調節済み薬物製剤を電気的移送式投与系の薬物溜めに組み入れる ことを特徴とする、請求項1記載の方法。 19.ドナー溜めがゲルを含むことを特徴とする、請求項18記載の方法。 20.溶液のpHを、他のpHレベルにおける治療剤流量に比べて、体表を 通る高い電気的移送式治療剤流量を示すレベルに調節することを特徴とする、請 求項1記載の方法。 21.ドナー電極(22)と、カウンター電極(24)と、ドナー電極(2 2)とカウンター電極(24)とに電気的に接続するのに適した電源(19、4 0)とを含み、電極(22、24)の少なくとも一方が、動物の体表を通して投 与されるべき治療剤溶液を含有する溜め(26)と結合し、溜め(26)が体表 に対して薬物伝達関係で配置されるのに適する電気的移送式薬物投与デバイスに おいて、 治療剤が、実質的に競合イオン種を含まないpH調節済み製剤として供給され ることを特徴とするデバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/443,173 | 1995-05-03 | ||
US08/433,173 US5853383A (en) | 1995-05-03 | 1995-05-03 | Preparation for formulations for electrotransport drug delivery |
PCT/US1996/005994 WO1996034597A1 (en) | 1995-05-03 | 1996-04-19 | Preparation of formulations for electrotransport drug delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11504923A true JPH11504923A (ja) | 1999-05-11 |
JP4026850B2 JP4026850B2 (ja) | 2007-12-26 |
Family
ID=23719114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53342196A Expired - Fee Related JP4026850B2 (ja) | 1995-05-03 | 1996-04-19 | 電気的移送式薬物投与のための製剤の製造 |
Country Status (8)
Country | Link |
---|---|
US (2) | US5853383A (ja) |
EP (1) | EP0824342B1 (ja) |
JP (1) | JP4026850B2 (ja) |
AT (1) | ATE186835T1 (ja) |
DE (1) | DE69605298T2 (ja) |
DK (1) | DK0824342T3 (ja) |
ES (1) | ES2141496T3 (ja) |
WO (1) | WO1996034597A1 (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU754882B2 (en) * | 1996-02-20 | 2002-11-28 | Computer Motion, Inc. | A method and apparatus for performing minimally invasive cardiac procedures |
US6718201B1 (en) * | 1996-06-07 | 2004-04-06 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US5991655A (en) * | 1997-03-03 | 1999-11-23 | Drug Delivery Systems, Inc. | Iontophoretic drug delivery device and method of manufacturing the same |
CA2341446C (en) | 1998-08-31 | 2008-10-07 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
CA2370349C (en) | 1999-04-16 | 2013-01-29 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport delivery system comprising internal sensors |
AU6076200A (en) | 1999-07-08 | 2001-01-30 | Johnson & Johnson Consumer Companies, Inc. | Exothermic bandage |
US6890553B1 (en) | 1999-07-08 | 2005-05-10 | Johnson & Johnson Consumer Companies, Inc. | Exothermic topical delivery device |
US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
US7133717B2 (en) * | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
JP4414517B2 (ja) | 1999-09-01 | 2010-02-10 | 久光製薬株式会社 | イオントフォレーシス用デバイス構造体 |
US7404815B2 (en) * | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
US6629968B1 (en) * | 2000-06-30 | 2003-10-07 | Vyteris, Inc. | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode |
DE60110245T2 (de) * | 2000-09-11 | 2006-03-09 | Alza Corp., Mountain View | Vorrichtung zur transdermalen verabreichung von medikamenten und entsprechendes herstellungsverfahren |
US6591133B1 (en) * | 2000-11-27 | 2003-07-08 | Microlin Llc | Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices |
WO2003047689A1 (en) * | 2001-11-29 | 2003-06-12 | Microlin Llc | Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices |
US7567313B2 (en) * | 2003-07-10 | 2009-07-28 | Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. | Bezel design for surface mount display modules |
AU2004268616B2 (en) * | 2003-08-25 | 2010-10-07 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
DE602004008502T2 (de) * | 2003-11-19 | 2008-01-03 | Alza Corp., Mountain View | Herstellungsverfahren einer Zusammensetzung zur Verwendung in einem Elektrotransportabgabesystem |
US20070025869A1 (en) * | 2005-07-15 | 2007-02-01 | Gordon John H | Fluid Delivery Device |
US20080147186A1 (en) * | 2006-12-14 | 2008-06-19 | Joshi Ashok V | Electrochemical Implant For Delivering Beneficial Agents |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2579283A (en) * | 1950-07-21 | 1951-12-18 | Du Pont | Production of lysine monohydro-chloride |
US4203440A (en) * | 1978-10-23 | 1980-05-20 | Alza Corporation | Device having variable volume chamber for dispensing useful agent |
US4203441A (en) * | 1978-12-18 | 1980-05-20 | Alza Corporation | Osmotically triggered device with gas generating means |
US4847077A (en) * | 1984-07-18 | 1989-07-11 | Pennwalt Corporation | Controlled release pharmaceutical preparations |
FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
EP0199855A1 (en) * | 1985-05-02 | 1986-11-05 | Gist-Brocades N.V. | Tablets comprising tromethoprim and a sulfonamide |
US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US4915685A (en) * | 1986-03-19 | 1990-04-10 | Petelenz Tomasz J | Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange |
US5080646A (en) * | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US4894239A (en) * | 1987-06-02 | 1990-01-16 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and production thereof |
EP0318776A1 (en) * | 1987-12-04 | 1989-06-07 | Robert Tapper | Method and apparatus for minimizing skin injury with electrode use |
US5147296A (en) * | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5169382A (en) * | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
EP0429842B1 (en) * | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
SI9300097B (en) * | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
GB2265088B (en) * | 1992-03-10 | 1996-02-07 | Kyosti Eero Antero Kontturi | Electrochemical device for drug delivery |
PH31437A (en) * | 1993-08-27 | 1998-11-03 | Janssen Pharmaceutica Nv | Tontophoretic delivery of an antimigrane drug. |
-
1995
- 1995-05-03 US US08/433,173 patent/US5853383A/en not_active Expired - Lifetime
-
1996
- 1996-04-19 ES ES96913866T patent/ES2141496T3/es not_active Expired - Lifetime
- 1996-04-19 DE DE69605298T patent/DE69605298T2/de not_active Expired - Lifetime
- 1996-04-19 JP JP53342196A patent/JP4026850B2/ja not_active Expired - Fee Related
- 1996-04-19 AT AT96913866T patent/ATE186835T1/de not_active IP Right Cessation
- 1996-04-19 WO PCT/US1996/005994 patent/WO1996034597A1/en active IP Right Grant
- 1996-04-19 DK DK96913866T patent/DK0824342T3/da active
- 1996-04-19 EP EP96913866A patent/EP0824342B1/en not_active Expired - Lifetime
-
1997
- 1997-12-18 US US08/993,213 patent/US6071508A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE186835T1 (de) | 1999-12-15 |
EP0824342B1 (en) | 1999-11-24 |
WO1996034597A1 (en) | 1996-11-07 |
US5853383A (en) | 1998-12-29 |
DK0824342T3 (da) | 2000-04-03 |
JP4026850B2 (ja) | 2007-12-26 |
DE69605298D1 (de) | 1999-12-30 |
DE69605298T2 (de) | 2000-04-13 |
US6071508A (en) | 2000-06-06 |
EP0824342A1 (en) | 1998-02-25 |
ES2141496T3 (es) | 2000-03-16 |
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