JPH11269035A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for the skin external use for the skin excellent in lipid degradation facilitative effect and skin-roughening improvement effect. SOLUTION: This preparation for external use for skin contains a xanthine derivative, a polysaccharide and at least one kind of following compounds: glycine, valine, leucine, isoleucine, phenylalamine, serine, alanine, tyrosine, tyrosine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, glutamic acid, glutamine, lysine, arginine, histidine, trimethyl glycine, and glutatione.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external preparation for skin having an excellent effect of promoting lipid decomposition and an effect of improving skin roughness.

[0002]

2. Description of the Related Art Conventionally, in order to reduce excess fat and maintain a firm body, in addition to various exercises and dietary restrictions, use of skin cosmetics such as gels and creams that promote metabolism in the body. It has been known.

[0003] Such cosmetics contain a xanthine derivative for the purpose of promoting lipolysis of fat cells constituting fat for the purpose of slimming.

[0004] On the other hand, polysaccharides are generally blended in skin cosmetics for the purpose of improving rough skin.

[0005]

However, in the conventional skin cosmetics intended for the slimming effect, the effect of promoting the lipid decomposition of fat cells is not always sufficient at present.

The present inventor has conducted intensive studies on the lipolytic effect of a xanthine derivative in view of the above viewpoints. As a result, surprisingly, when a xanthine derivative, a polysaccharide and a certain specific compound are blended in an external preparation for skin. The present inventors have found that the effect of promoting lipid decomposition of fat cells and the effect of improving skin roughness are synergistically extremely enhanced, and have completed the present invention.

[0007] An object of the present invention is to provide an external preparation for skin which is extremely excellent in promoting lipid decomposition of fat cells and improving skin roughness.

[0008]

That is, the present invention provides a skin external preparation characterized by comprising a xanthine derivative, a polysaccharide, and at least one of the following specific compounds (1). Is what you do. (1) glycine, valine, leucine, isoleucine, phenylalanine, serine, alanine, tyrosine, threonine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, arginine, glutamic acid, glutamine, lysine, arginine,
Histidine, trimethylglycine, glutathione.

In the present invention, the xanthine derivative is one or more selected from the group consisting of caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxylphyrin and oxtriphline. The above-mentioned external preparation for skin is provided.

[0010] The present invention further relates to the present invention, wherein the polysaccharide is one or more selected from the group consisting of erythritol, sialic acid, trehalose, glucosamine, glucuronic acid, dextran, mucoitin sulfate, hyaluronic acid, and salts thereof. The above-mentioned external preparation for skin is provided.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The xanthine derivatives used in the present invention include, for example, caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxylphyrin, oxtriphylline, etc., and particularly, caffeine, aminophylline, theophylline and the like. Is preferred. These can be used alone or in combination of two or more. As these derivatives, synthetic or those obtained from plants such as tea leaves can be used, and commercially available products can be used.

The amount of the xanthine derivative incorporated into the external preparation for skin is 0.0001% by weight or more, preferably 0.005 to 10.0% by weight, based on the total amount of the external preparation for skin.

The polysaccharide used in the present invention is preferably erythritol, sialic acid, trehalose, glucosamine, glucuronic acid, dextran, mucoitin sulfate, hyaluronic acid, or the like. These can be used alone or in combination of two or more.

The amount of the polysaccharide incorporated into the external preparation for skin is 0.0001% by weight or more, preferably 0.001 to 10.0% by weight, based on the total amount of the external preparation for skin.

In the present invention, the specific compound to be compounded together with the above essential components is at least one of the specific compounds shown in the following (1), and it is possible to use one of them alone or in combination of two or more. it can. (1) glycine, valine, leucine, isoleucine, phenylalanine, serine, alanine, tyrosine, threonine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, arginine, glutamic acid, glutamine, lysine, arginine,
Histidine, trimethylglycine, glutathione.

The compounding amount of the above specific compound in the external preparation for skin is 0.001% by weight or more, preferably 0.001% by weight.
5 to 10% by weight.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, other components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, powder components, liquid oils and fats, solid oils and fats, waxes and hydrocarbons. , Higher fatty acids, higher alcohols, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, humectants, water-soluble polymer compounds, thickeners, filming agents, ultraviolet rays Absorbents, sequestering agents, lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, synthetic resin emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidants, fragrances, Water and the like can be appropriately compounded as necessary, and can be produced by a conventional method according to the intended dosage form. The specific components that can be mixed are listed below,
The skin external preparation of the present invention can be prepared by mixing the above essential components and one or more of the following components.

Examples of the powder component include talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, phlogopite, biotite, litthic mica, permiculite,
Magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate, (calcium gypsum), calcium phosphate , Fluorine apatite, hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate), inorganic powder such as boron nitride, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, Organic powders such as polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, and inorganic white such as titanium dioxide and zinc oxide. Pigments, iron oxide (red iron oxide),
Inorganic red pigments such as iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as loess black iron oxide, carbon black, inorganic black pigments such as lower titanium oxide, Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine blue and dark blue; titanium oxide coated mica; titanium oxide coated bismuth oxychloride , Titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil, aluminum powder,
Metal powder pigments such as copper powder, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red 220
No. Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401
No. 3, and organic pigments such as Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No. Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
Organic pigments such as zirconium, barium or aluminum lakes such as No. 1 and Blue No. 1, and natural pigments such as chlorophyll and β-carotene. However, the powder may be any powder that can be applied to general cosmetics, and is not limited to the above components.

Liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern oil, castor oil, flaxseed oil Oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin,
Glycerin trioctanoate, glycerin triisopalmitate and the like can be mentioned.

Examples of solid fats and oils include cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, tallow, sheep butter, hardened tallow, palm kernel oil, lard, beef bone fat, mokuro kernel oil, hardened oil, Beef leg fat, mokuro, hardened castor oil and the like.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibotaro wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, isopropyl lanolin fatty acid, hexyl laurate, reduction Lanolin, Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, and the like.

Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax and the like.

The higher fatty acids include, for example, lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid Acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the like.

Examples of the higher alcohol include straight-chain alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), and 2-decyltetradecyl alcohol. And branched chain alcohols such as knol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol and the like.

As synthetic ester oils, isopropyl myristate, cetyl octoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate,
Decyl oleate, hexyl decyl dimethyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 1
Cholesteryl 2-hydroxystearylate, ethylene glycol di-2-ethylhexylate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate Trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, glyceride tri-2-heptylundecanoate, methyl ester of castor oil fatty acid, oleic oil, cetostearyl alcohol , Acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2 sebacate -Ethylhexyl, 2-hexyldecyl myristate, palmitic acid
2-hexyldecyl, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate and the like.

Examples of the silicone include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. Polysiloxane, silicon resin forming a three-dimensional network structure, silicone rubber, trimethylsiloxysilicate-octamethylcyclotetrasiloxane solution (50%), and the like.

Examples of the anionic surfactant include soap base, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, and POE-triethanolamine lauryl sulfate. , POE-alkyl ether sulfates such as sodium lauryl sulfate, N-acyl sarcosine acids such as lauroyl sarcosine sodium, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium and the like. Higher fatty acid amide sulfonates, POE-oleyl ether sodium phosphate, phosphate ester salts such as POE-stearyl ether phosphoric acid, sodium di-2-ethylhexyl sulfosuccinate,
Sodium lauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate, sodium linear dodecylbenzene sulfonate,
Alkyl benzene sulfonates such as linear dodecylbenzenesulfonic acid triethanolamine and linear dodecylbenzenesulfonic acid, monosodium N-lauroylglutamate, disodium N-stearoylglutamate,
N- such as N-myristoyl-L-monosodium glutamate
Acyl glutamates, higher fatty acid ester sulfates such as hydrogenated coconut oil fatty acid sodium glycerin sulfate,
Sulfated oil such as funnel oil, POE-alkyl ether carboxylic acid, POE-alkyl allyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide Sulfate, sodium lauroyl monoethanolamidosuccinate, ditriethanolamine N-palmitoyl aspartate, sodium caseinate and the like.

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, distearyldimethylammonium dialkyldimethylammonium chloride, and poly (N, N'-dimethylchloride).
Alkylpyridinium salts such as -3,5-methylenepiperidinium), cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts, dialkylmorphonium salts, POE-alkylamines, Examples thereof include alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-
Imidazoline amphoteric surfactants such as imidazoline sodium, 2-cocoyl-2-imitazolinium hydroxide-1-carboxyethyloxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine And betaine-based surfactants such as betaine, lauryldimethylaminoacetate, alkylbetaine, amidobetaine and sulfobetaine.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Diglycerol sorbitan penta-2-ethylhexylate,
Sorbitan fatty acid esters such as diglycerol sorbitan tetra-2-ethylhexylate, glycerin mono-cottonseed oil, glyceryl monoerucate, glycerin sesquioleate, glyceryl monostearate, α, α'-glyceryl pyroglutamate oleate, glycerin monostearate Glycerin polyglycerin fatty acids such as malic acid; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ether;

Examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters such as POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and the like. POE sorbit fatty acid esters such as POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbit pentaoleate, POE-sorbit monostearate, POE-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin fatty acid esters such as POE-glycerin triisostearate, POE-monooleate, POE-distearate,
POE-monodioleate, POE-fatty acid esters such as ethylene glycol cysteate, POE-lauryl ether, POE-oleyl ether, POE-stearyl ether,
POE-alkyl ethers such as POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, POE such as POE-octylphenyl ether, POE-nonylphenyl ether, POE-dinonylphenyl ether
E-alkyl phenyl ethers, pluronic type such as bruronic, POE / POP-cetyl ether, POE / POP-
POE / POP-alkyl ethers such as 2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, and tetraPOE / tetraPOP-ethylenediamine condensation such as tetronic Products, POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate diester, POE-hardened POE such as castor oil maleic acid-castor oil-hardened castor oil derivative, POE-
POE-beesol lanolin derivatives such as sorbit beeswax, alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, POE-propylene glycol fatty acid ester, POE-alkylamine, POE-fatty acid amide, sucrose Fatty acid esters, POE-nonylphenylformaldehyde condensates, alkylethoxydimethylamine oxide, trioleyl phosphoric acid, and the like.

Examples of the humectant include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12- Examples include hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, adducts of diglycerin (EO) PO, extracts of L. japonicum, extracts of Achillea millefolium, and extracts of melilot.

Examples of natural water-soluble polymers include, for example, arabia gum, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), alge colloid (cassow extract), starch (rice, corn, Potato, wheat), plant polymers such as glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, burlan, collagen,
Animal-based polymers such as casein, albumin, and gelatin are exemplified.

As the semi-synthetic water-soluble polymer, for example,
Carboxymethyl starch, starch-based polymers such as methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, cellulose sodium sulfate, hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose And alginic acid-based polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymer (Carbopol), and polyethylene glycol.
20,000, 40,000, 60,000 and other polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer copolymer polymers, sodium polyacrylate, polyethyl acrylate, acrylic polymers such as polyacrylamide, polyethylene imine, And cationic polymers.

Examples of the inorganic water-soluble polymer include bentonite, silicic acid A1Mg (veegum), laponite, hectorite, silicic anhydride and the like.

As the thickener, for example, gum arabic,
Carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose,
CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium cellulose sulfate, xanthan gum, aluminum magnesium silicate, bentonite,
Hectorite and the like.

Examples of the ultraviolet absorber include para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N,
N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-
Benzoic acid UV absorbers such as dimethyl PABA ethyl ester, anthranilic acid UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p -Salicylic acid UV absorbers such as -isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-
Diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl- p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2- Ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-
Cinnamic acid UV absorbers such as diparamethoxycinnamate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-
4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxy Benzophenone ultraviolet absorbers such as benzophenone, 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methyl Benzoxazole, 2,2'-hydroxy-5
-Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2-
(2'-Hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy
-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-
Norbornylidene) -3-pentan-2-one and the like.

Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, edetate Tetrasodium acid, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid,
Ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyltriacetate and the like.

As the lower alcohol, for example, methanol, ethanol, propanol, isopropanol,
Isobutyl alcohol, t-butyl alcohol and the like.

Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene. Dihydric alcohols such as glycol, 2-butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as glycerin, trimethylolpropane and 1,2,6-hexanetriol; pentaerythritol And pentahydric alcohols such as xylitol, sorbitol and hexahydric alcohols such as mannitol, diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, and polyethylene glycol. Polyol, triglycerin, tetraglycerin, polyglycerol and other polyhydric alcohol polymers, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether,
Dihydric alcohol alkyl ethers such as ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol monomethyl ether , Diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, Dihydric alcohol alkyl ethers such as propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, ethylene glycol monomethyl ether Acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate Glycerin monoalkyl such as dihydric alcohol ether ester such as propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, xyl alcohol, seralkyl alcohol and butyl alcohol Ether, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol,
Glucose, fructose, starch-decomposed sugar, maltose, xylitol, sugar alcohol such as starch-decomposed sugar-reducing alcohol, glysolid, tetrahydrofurfuryl alcohol, POE-tetrahydrofurfuryl alcohol, POP-butyl ether, POP / POE-butyl ether,
Tripolyoxypropylene glycerin ether, POP-glycerin ether, POP-glycerin ether phosphoric acid, PO
P.POE-pentaneerythritol ether and the like.

Examples of the monosaccharide include tricarbonates such as D-glyceryl aldehyde and dihydroxyacetone, tetracarbons such as D-erythrose, D-erythrulose, D-threose and erythritol, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose,
Pentoses such as D-xylulose and L-xylulose, D-glucose, D-talose, D-bucose, D-galactose, D-
Hexagonal sugars such as fructose, L-galactose, L-mannose, D-tagatose, etc., heptose sugars such as aldheptose, heppulose, etc., octylose such as octulose, 2-deoxy-D-ribose, 6-deoxy-L-galactose , Deoxy sugars such as 6-deoxy-L-mannose, D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, amino sugars such as muramic acid, D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D -Uronic acids such as galacturonic acid and L-iduronic acid;

Examples of the oligosaccharide include sucrose, guntianose, umbelliferose, lactose, planteose, isoliqunoses, α, α-trehalose,
Raffinose, liqunoses, umbilicin, stachyose bell bath courses and the like.

Polysaccharides include, for example, cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran Keratosulfuric acid, locust bingham, succinoglucan, caronic acid and the like.

Examples of the amino acids include neutral amino acids such as threonine and cysteine, and basic amino acids such as hydroxylysine. Examples of amino acid derivatives include acyl sarcosine sodium (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1 -Propanol and the like.

As the synthetic resin emulsion, for example,
An acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and the like are included.

Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate and citric acid-sodium citrate.

Examples of the vitamins include vitamins A, B1, B2, B6, E and derivatives thereof, pantothenic acid and derivatives thereof, and biotin.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic esters and the like.

As the antioxidant aid, for example, phosphoric acid,
Examples thereof include citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

Other components that can be blended include preservatives such as ethyl paraben and butyl paraben, glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives,
Anti-inflammatory agents such as hinokitiol, zinc oxide, allantoin,
Whitening agents such as placenta extract and Saxifraga extract, oak,
Spinach, siconium, peonies, squirrel, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokuinin, loofah, lily, saffron, senkyu, ginger, chrysanthemum, tinpi, squid, seaweed Extract, royal jelly, photosensitizer, cholesterol derivative,
Activators such as infant blood extract, nonylate valenylamide,
Nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, gingerone, cantharistin tincture, ittamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandate, cinnarizine, trazoline, acetylcholine, verapamil , Cepharanthin,
blood circulation promoters such as γ-oryzanol; antiseborrheic agents such as sulfur and thiantol; tranexamic acid; thiotaurine; hypotaurine;

The dosage form of the external preparation for skin of the present invention is optional.
For example, any dosage form such as a solubilizing system such as a lotion, an emulsion system such as a milk or a cream, or an ointment or a dispersion can be used.

[0055]

Next, the present invention will be described in more detail by way of examples. The present invention is not limited by this. The compounding amount is% by weight. Prior to the examples, the effect test method and the evaluation method of the present invention will be described.

(1) Lipid degradation effect test and evaluation method Adipocytes were isolated from adipose tissue by the method of Rodbell (M.
Rodbell, J. B. C. 239 (2), 1964). The human adipose tissue obtained by liposuction into 2-3 mm strips,
Incubation at 37 ° C., 45-60 in a 0.05% collagenase solution (containing Banks buffer, 4% glucose).
Minute). Thereafter, the mixture was filtered to remove undigested adipose tissue, and centrifuged (1000 rpm, 1 minute). Adipocytes have a specific gravity of less than 1 and float on top. The lower layer solution was removed, and a culture solution (199 medium, containing 10% newborn calf serum) was added, followed by redispersion. Centrifugation and medium addition were repeated twice to remove collagenase. Finally, 30 ml of the medium described in Table 1 was added,
After the cells were dispersed, they were rotated and cultured for 1 day. In each sample, the xanthine derivative was 0.2% by weight and the specific compound was 0.5% by weight. The lipid content of adipocytes before and after the culture was quantified using Triglyceride-Test Wako (Wako Pure Chemical Industries, Ltd.) (color reagent for lipid determination) to determine the amount of degraded lipid (mg / tube). The measurement results are shown in "Table 1".

[0057]

[Table 1] ---------------------------------------------- ------------------------- Sample Decomposed lipid amount (mg / tube) ---------------- -------------------------------------------------- ----- Not added 1.20 ± 0.18 ------------------------------------ ----------------------------------- Caffeine 3.50 ± 0.56 ------ -------------------------------------------------- --------------- Caffeine + erythritol + trimethylglycine 8.25 ± 0.20 ---------- -------------------------------------------------- Aminophylline + hyaluronic acid + serine 8.65 ± 0.35 ------------------------------------- ---------------------------------- Caffeine + erythritol + L-serine + trimethylglycine 7.45 ± 0. 89 ------------------------------------------------- ----------------------

From Table 1, it can be seen that when a xanthine derivative, a polysaccharide and a specific compound are blended, the lipolytic effect is promoted.

(2) Lipid Metabolism Promoting Effect Test, Skin Roughness Improving Effect Test and Evaluation Method A massage gel of Example 7, which will be described later, was applied to 100 women in their 20s and 30s on the whole body in the morning and evening, and used continuously for 2 months. The body fat percentage before and after continuous use (the ratio of fat to the whole body) is measured using a measuring instrument based on the principle of light reflection at the outside infrared wavelength (body fat meter BFT-200).
0, manufactured by Kett Science). Forty of the 100 subjects were taken as a control group from which erythritol, caffeine, and trimethylglycine had been removed, and the average value of each body fat percentage was determined. The results are shown in Table 3. In addition, the degree of rough skin of the legs was evaluated in four steps based on the evaluation criteria of “Table 2”, and the results are shown in “Table 4”.

[0060]

[Table 2] "Roughness of skin" ----------------------------------------- ----------------------- Score Observation state ------------------------ ---------------------------------------- 0 No rough skin on legs 1 The skin is slightly rough on the legs 2 The skin is rough on the legs 3 The skin is rough as if the whole leg was dusted. -------------------------------------------

[0061]

[Table 3] "Changes in body fat percentage" --------------------------------------- ------------------------- Before continuous use After continuous use --------------------- ------------------------------------------- Control 35.5 ± 7. 2% 35.2 ± 4.0% Example 7 36.2 ± 4.2% 32.6 ± 8.8% --------------------- -------------------------------------------

[0062]

[Table 4] "Effect of improving skin roughness" ----------------------------------------- ----------------------- Before continuous use After continuous use ----------------------- ----------------------------------------- Control 3.1 ± 1.5 3.5 ± 1.2 Example 7 3.3 ± 1.9 2.2 ± 1.6 ------------------------------------------- ---------------------

As is clear from the results of Tables 3 and 4, the examples of the present invention have a reduced body fat percentage and a remarkable effect of improving skin roughness as compared with the control.

Examples of the external preparation for skin of the present invention are shown below.

Example 1 Cream (1) 3.5% by weight of cetostearyl alcohol (2) Squalane 40.0 (3) Beeswax 3.0 (4) Reduced lanolin 5.0 (5) Ethyl paraben 0.3 (6 ) Polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) Monoglyceride stearate 2.0 (8) Sodium N-stearoylglutamate 0.5 (9) 2-Hydroxy-4-methoxybenzophenone 1.0 ( 10) Fragrance 0.05 (11) Caffeine 1.0 (12) Trimethylglycine 0.2 (13) 1,3-butylene glycol 0.1 (14) Erythritol 0.5 (15) Purified water residue (Manufacturing method) (1) to (10) were dissolved by heating and heated to 70 ° C (1
Add to 1) to (15) with stirring. After homogenizing the emulsion to make the emulsified particles fine, the mixture was rapidly cooled while stirring to obtain a cream.

Example 2 Lotion (1) Caffeine 0.5% by weight (2) Trimethylglycine 0.5 (3) Erythritol 0.1 (4) Glycerin 4.0 (5) 1,3-butylene glyco- 4.0 (6) Tocopherol acetate 0.05 (7) Ethanol 7.0 (8) Polyoxyethylene (18) oleyl alcohol ether 0.5 (9) Methylparaben 0.2 (10) Citric acid 0.05 ( 11) Sodium citrate 0.1 (12) Trisodium ethylenediaminetetraacetate 0.02 (13) Fragrance 0.05 (14) Purified water residue (Production method) Purified water (1) to (5), (10) Dissolve (12) (aqueous phase). (7), (6), (8),
(9) and (13) were dissolved, added to the above-mentioned aqueous phase, solubilized, and filtered to obtain a lotion.

Example 3 Emulsion (1) 1.5% by weight of stearic acid (2) Cetyl alcohol 0.5 (3) Beeswax 2.0 (4) Polyoxyethylene (10) monooleate 1.0 (5 ) Octyl methoxycinnamate 2.0 (6) Caffeine 0.2 (7) L-serine 0.5 (8) Sodium hyaluronate 0.01 (9) Triethanolamine 0.75 (10) Glycerin 7. 0 (11) Inosit 0.5 (12) 1,3-butylene glycol 0.5 (13) DL-alanine 0.2 (14) Ethylenediaminehydroxyethyl triacetate trisodium 0.01 (15) Ethyl paraben 0.3 (16) Fragrance 0.03 (17) Purified water residue (Production method) Add (6) to (14) to (17) and maintain at 70 ° C (aqueous phase). Mix other components, heat and maintain at 70 ° C (oil phase). Preliminary emulsification is performed by adding an oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled while stirring to obtain an emulsion.

Example 4 Foam Pack (1) L-arginine 0.1% by weight (2) Caffeine 1.0 (3) DL-serine 0.2 (4) Sodium metaphosphate 0.02 (5) Trehalose 2 0.0 (6) Glycerin 7.0 (7) Methylparaben 0.1 (8) Potassium hydroxide 0.15 (9) Stearic acid 0.5 (10) Myristic acid 1.0 (11) Bacyl alcohol 1.5 ( 12) Polyoxyethylene (60) hydrogenated castor oil 3.0 (13) Fragrance 0.05 (14) Liquefied petroleum gas 6.0 (15) Dimethyl ether 3.0 (16) Purified water residue (Production method) (16) (1) to (8) are added to the mixture, and the mixture is heated and dissolved at 70 ° C., and the mixture obtained by heating and stirring (9) to (13) at 75 ° C. is added thereto. This was filled in a container, and finally (14) and (15) were filled as a propellant to obtain a foam pack.

Example 5 Ointment (1) Caffeine 10.0% by weight (2) Rosemary extract 1.0 (3) Trehalose 0.2 (4) Trimethylglycine 0.2 (5) Ethylenediaminehydroxyethyl triacetic acid Trisodium 0.01 (6) Retinol palmitate 0.5 (7) Stearyl alcohol 18.0 (8) Mokuro 20.0 (9) Polyoxyethylene (20) monooleate 0.25 (10) Glycerin mono Stearic acid ester 0.3 (11) Vaseline 40.0 (12) Purified water residue (Preparation method) Add (1) to (5) to (12), dissolve and maintain at 70 ° C (aqueous phase). The remaining components (6) to (11) are mixed and dissolved at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, uniformly emulsified with a homomixer, and then cooled to obtain an ointment.

Example 6 Emulsion for Massage (1) 1.5% by weight of stearic acid (2) Cetyl alcohol 0.5 (3) Polyoxyethylene (10) monooleate 1.0 (4) Vaseline 3.0 (5) Squalane 10.0 (6) Liquid paraffin 5.0 (7) Glycerin 7.0 (8) Glutathione 0.2 (9) Triethanolamine 0.75 (10) L-serine 0.05 (11) Caffeine 1.0 (12) Green tea extract 3.0 (13) Trehalose 2.0 (14) Sodium metaphosphate 0.02 (15) Ethylenediaminehydroxyethyl trisodium triacetate 0.01 (16) Ethyl paraben 25 (17) Fragrance 0.02 (18) Purified water residue (Preparation method) Add (7) to (15) to (18) and maintain at 70 ° C (aqueous phase). Mix other components, heat and maintain at 70 ° C (oil phase). Preliminary emulsification is performed by adding an oil phase to the water phase, and the mixture is uniformly emulsified with a homomixer. Thereafter, the mixture was rapidly cooled with stirring to obtain a milky lotion for massage.

Example 7 Massage Gel (1) Erythritol 2.0% by weight (2) Caffeine 5.0 (3) Oleum extract 3.0 (4) Glycerin 50.0 (5) Trimethylglycine 0.2 (6) Carboxyvinyl polymer 0.40 (7) Polyethylene glycol 400 30.0 (8) Ethylenediaminehydroxyethyl trisodium triacetate 0.1 (9) Polyoxyethylene (10) methylpolysiloxane copolymer 2.0 (10) Squalane 1.0 (11) Fragrance 0.12 (12) Potassium hydroxide 0.15 (13) Purified water residue (Production method) Dissolve (1) to (8) in (13). Separately (9)
After adding a mixture of (11) to (11), (12) was added to obtain a massage gel.

Example 8 Serum (1) Caffeine 5.0% by weight (2) Tranexamic acid 1.0 (3) Rosemary extract 0.1 (4) L-arginine L-aspartate 0.1 (5) Sodium hyaluronate 0.01 (6) Glycerin 10.0 (7) Erythrilol 5.0 (8) Carboxyvinyl polymer 0.3 (9) Ethylenediaminehydroxyethyl triacetate trisodium 0.01 (10) Ethanol 7.0 (11) Polyoxyethylene (18) oleyl alcohol ether 0.8 (12) Macadamia nut oil 0.1 (13) Evening primrose oil 0.01 (14) Tocopherol acetate 0.01 (15) Methyl paraben 0.15 ( 16) Fragrance 0.1 (17) Potassium hydroxide 0.08 (18) Purified water residue (Preparation method) Dissolve (1) to (9) in (18), and separately dissolve (11) to (11) in (10) Add the solution of 16). Then (1
7) was added to obtain a serum.

[0073]

According to the present invention, it is possible to provide an external preparation for skin having an extremely excellent effect of accelerating lipid decomposition and improving skin roughness.

Claims (3)

[Claims] 1. A skin external preparation comprising a xanthine derivative, a polysaccharide, and at least one of the following specific compounds (1). (1) glycine, valine, leucine, isoleucine, phenylalanine, serine, alanine, tyrosine, threonine, proline, hydroxyproline, tryptophan, methionine, cystine, aspartic acid, arginine, glutamic acid, glutamine, lysine, arginine,
Histidine, trimethylglycine, glutathione. 2. The method according to claim 1, wherein the xanthine derivative is caffeine,
2. The composition according to claim 1, which is one or more selected from the group consisting of theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline, and oxtriphylline.
The topical skin preparation according to the above. 3. The polysaccharide is one or more selected from the group consisting of erythritol, sialic acid, trehalose, glucosamine, glucuronic acid, dextran, mucoitin sulfate, hyaluronic acid, and salts thereof. The external preparation for skin according to claim 1 or 2, wherein