JPH11209253A - Composition for oral cavity - Google Patents
Composition for oral cavityInfo
- Publication number
- JPH11209253A JPH11209253A JP1106298A JP1106298A JPH11209253A JP H11209253 A JPH11209253 A JP H11209253A JP 1106298 A JP1106298 A JP 1106298A JP 1106298 A JP1106298 A JP 1106298A JP H11209253 A JPH11209253 A JP H11209253A
- Authority
- JP
- Japan
- Prior art keywords
- xylitol
- weight
- sugar alcohol
- water
- oral composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明はキシリトール結晶の
析出が抑制された口腔用組成物に関する。The present invention relates to an oral composition in which the deposition of xylitol crystals is suppressed.
【０００２】[0002]
【従来の技術】従来よりキシリトールはむし歯になりに
くい糖アルコールとして知られており、洗口剤、練歯磨
剤等の口腔用組成物にも使用されてきた。かかるキシリ
トールの効果を充分に奏させるためには、キシリトール
の濃度を高くする必要がある。2. Description of the Related Art Xylitol has been conventionally known as a sugar alcohol which hardly forms caries, and has been used in oral compositions such as mouth washes and toothpastes. In order to sufficiently exert the effect of xylitol, it is necessary to increase the concentration of xylitol.
【０００３】しかしながら、キシリトールの水に対する
溶解度は２５℃で６４（ｇ／１００ｇ）であり、キシリ
トールを口腔用組成物に溶解状態で配合しようとする場
合、高濃度に配合すると結晶が析出し、均質な性状を保
つことができないため、その配合量には制限があった。
そこで、キシリトールの結晶化を抑制するため、マルチ
トール、ソルビトール、マンニトール、グリセリン等の
多価アルコールを一定比率で配合する方法が知られてい
る（米国特許第５１４４０２４号）。[0003] However, the solubility of xylitol in water is 64 (g / 100 g) at 25 ° C. When xylitol is to be incorporated in a composition for oral cavity in a dissolved state, crystals are precipitated at a high concentration and homogenized. Since the proper properties cannot be maintained, the blending amount is limited.
Therefore, in order to suppress crystallization of xylitol, a method of blending a polyhydric alcohol such as maltitol, sorbitol, mannitol, and glycerin at a fixed ratio is known (US Pat. No. 5,144,024).
【０００４】[0004]
【発明が解決しようとする課題】ところが、その結晶化
防止手段は、未だ充分でなく、更に多量のキシリトール
を溶解状態で配合できる口腔用組成物の開発が求められ
ていた。従って、本発明の目的は、キシリトールを高濃
度に含有しても結晶析出がなく、安定な口腔用組成物を
提供することにある。However, the means for preventing crystallization is not yet sufficient, and there has been a demand for the development of an oral composition capable of blending a larger amount of xylitol in a dissolved state. Accordingly, an object of the present invention is to provide a stable oral composition without crystal precipitation even when xylitol is contained at a high concentration.
【０００５】[0005]
【課題を解決するための手段】そこで本発明者は上記課
題を解決すべく種々検討してきたところ、キシリトール
に加えてキシリトール以外の糖アルコールを配合し、更
にポリエチレングリコールを一定量配合すれば、キシリ
トールを高濃度に含有しても結晶析出がなく、長期間安
定な口腔用組成物が得られることを見出し、本発明を完
成するに至った。The inventor of the present invention has made various studies to solve the above-mentioned problems. As a result, when a sugar alcohol other than xylitol is added in addition to xylitol, and a certain amount of polyethylene glycol is added, xylitol can be obtained. It has been found that even if the compound is contained at a high concentration, no crystallization occurs and a long-term stable oral composition can be obtained, and the present invention has been completed.
【０００６】すなわち、本発明は、次の成分（ａ）、
（ｂ）及び（ｃ）： （ａ）糖アルコール中５０〜９０重量％のキシリトールを含有する糖アルコール 混合物 ５〜８０重量％ （ｂ）ポリエチレングリコール ２〜２０重量％ （ｃ）水 ５〜９０重量％ を含有する口腔用組成物を提供するものである。That is, the present invention provides the following component (a):
(B) and (c): (a) a sugar alcohol mixture containing 50-90% by weight of xylitol in the sugar alcohol 5-80% by weight (b) polyethylene glycol 2-20% by weight (c) water 5-90% by weight % Of the composition for oral cavity.
【０００７】[0007]
【発明の実施の形態】本発明に用いられる成分（ａ）
は、キシリトールを含有する糖アルコール混合物であ
り、当該糖アルコール混合物中キシリトールを５０〜９
０重量％含有する。糖アルコール中のキシリトール含量
が５０重量％未満の場合には、キシリトール配合による
むし歯になりにくいという効果が充分でなく、またキシ
リトール含量が９０重量％を超えるとキシリトール結晶
が析出しやすくなるので好ましくない。当該糖アルコー
ル混合物中の好ましいキシリトール含量は６０〜９０重
量％であり、特に好ましいキシリトール含量は７０〜９
０重量％である。DETAILED DESCRIPTION OF THE INVENTION Component (a) used in the present invention
Is a sugar alcohol mixture containing xylitol, wherein xylitol in the sugar alcohol mixture is 50 to 9
It contains 0% by weight. When the xylitol content in the sugar alcohol is less than 50% by weight, the effect of the compound containing xylitol to prevent the formation of cavity is not sufficient, and when the content of xylitol exceeds 90% by weight, xylitol crystals are easily precipitated, which is not preferable. . The preferred xylitol content in the sugar alcohol mixture is 60 to 90% by weight, and the particularly preferred xylitol content is 70 to 9%.
0% by weight.
【０００８】成分（ａ）中のキシリトール以外の糖アル
コールとしては、ソルビトール、マルチトール、マンニ
トール、パラチニトール、ラクチトール等が挙げられる
が、キシリトールの結晶析出防止性の点からソルビトー
ル及び／又はマルチトールが好ましい。Examples of the sugar alcohol other than xylitol in the component (a) include sorbitol, maltitol, mannitol, palatinitol, lactitol, etc., and sorbitol and / or maltitol are preferred from the viewpoint of preventing xylitol from crystallizing out. .
【０００９】当該成分（ａ）の口腔用組成物への配合量
は５〜８０重量％であるが、１０〜７０重量％、特に２
０〜６０重量％が好ましい。この配合量が５重量％未満
ではキシリトール配合による効果が充分得られず、一方
８０重量％を超えるとキシリトールの結晶が析出しやす
くなるので好ましくない。The compounding amount of the component (a) in the oral composition is 5 to 80% by weight, but is 10 to 70% by weight, particularly 2
0-60% by weight is preferred. When the amount is less than 5% by weight, the effect of the xylitol compounding cannot be sufficiently obtained. On the other hand, when the amount exceeds 80% by weight, crystals of xylitol tend to precipitate, which is not preferable.
【００１０】成分（ｂ）のポリエチレングリコールは、
キシリトール結晶析出防止効果を有するものであり、そ
の平均分子量としては２００〜１０００が好ましい。ま
た、ポリエチレングリコールの口腔用組成物への配合量
は２〜２０重量％であるが、３〜１２重量％、特に４〜
８重量％が好ましい。この配合量が２重量％未満では充
分なキシリトール結晶析出防止効果が得られず、２０重
量％を超えると苦みが強くなるので好ましくない。The polyethylene glycol of the component (b) is
It has an effect of preventing xylitol crystal precipitation, and its average molecular weight is preferably from 200 to 1,000. The amount of polyethylene glycol in the oral composition is 2 to 20% by weight, but 3 to 12% by weight, particularly 4 to 20% by weight.
8% by weight is preferred. When the amount is less than 2% by weight, a sufficient effect of preventing the precipitation of xylitol crystals cannot be obtained.
【００１１】本発明口腔用組成物には、水を５〜９０重
量％配合されるが、口腔用組成物の形態が洗口剤、水性
歯磨剤等の液状の場合には４０〜８０重量％が好まし
く、練歯磨剤等のペースト状の場合には２０〜６０重量
％が好ましい。水が５重量％未満の場合には、キシリト
ールを溶解状態にできず、９０重量％を超えると他の成
分の配合量を制限するので好ましくない。The oral composition of the present invention contains water in an amount of 5 to 90% by weight. When the oral composition is in a liquid form such as a mouthwash or an aqueous dentifrice, the composition is 40 to 80% by weight. In the case of a paste such as toothpaste, the content is preferably 20 to 60% by weight. When water is less than 5% by weight, xylitol cannot be dissolved, and when it exceeds 90% by weight, the amount of other components is limited, which is not preferable.
【００１２】また、本発明口腔用組成物においては、水
溶性アルカリ金属塩類又は水溶性アルカリ土類金属塩類
を配合することにより、キシリトールの結晶析出防止効
果を更に向上させることができる。これらの水溶性塩類
としては、無機酸の塩又は炭素数１〜６の有機酸の塩が
好ましく、より具体的には、水溶性アルカリ金属塩類と
しては、例えば、塩化ナトリウム、炭酸水素ナトリウ
ム、リン酸カリウム等が挙げられ、水溶性アルカリ土類
金属塩類としては、塩化カルシウム、乳酸カルシウム、
硫酸マグネシウム等が挙げられる。かかる水溶性塩類の
口腔用組成物への配合量は、特に制限されないが、０．
０５〜４０重量％、特に０．１〜２０重量％が好まし
い。In the oral composition of the present invention, the effect of preventing the precipitation of xylitol crystals can be further improved by adding a water-soluble alkali metal salt or a water-soluble alkaline earth metal salt. As these water-soluble salts, salts of inorganic acids or salts of organic acids having 1 to 6 carbon atoms are preferable. More specifically, as the water-soluble alkali metal salts, for example, sodium chloride, sodium hydrogen carbonate, phosphorus And the like. Examples of the water-soluble alkaline earth metal salts include calcium chloride, calcium lactate,
Magnesium sulfate and the like. The amount of the water-soluble salt to be added to the composition for oral cavity is not particularly limited, but may be from 0.1 to 0.1%.
It is preferably from 0.5 to 40% by weight, particularly preferably from 0.1 to 20% by weight.
【００１３】更に本発明口腔用組成物には、上記成分に
加えて、必要に応じて種々の成分、例えば、発泡剤、粘
結剤、抗菌剤、研磨剤、フッ素化合物、香料、他の甘味
料、湿潤剤、着色剤、保存剤、薬効成分等を配合するこ
とができる。ここで、発泡剤としては、例えば、ラウリ
ル硫酸ナトリウム、ラウロイルサルコシンナトリウム、
アルキルスルホコハク酸ナトリウム、ヤシ油脂肪酸モノ
グリセリンスルホン酸ナトリウム、ショ糖脂肪酸エステ
ル等が挙げられる。粘結剤としては、キサンタンガム、
カラギーナン、カルボキシメチルセルロースナトリウ
ム、ヒドロキシエチルセルロース等が挙げられ、研磨剤
としては無水ケイ酸等が挙げられる。Further, in addition to the above-mentioned components, various components such as a foaming agent, a binder, an antibacterial agent, an abrasive, a fluorine compound, a flavor, and other sweeteners may be added to the oral composition of the present invention, if necessary. Additives, wetting agents, coloring agents, preservatives, medicinal ingredients and the like can be incorporated. Here, as the foaming agent, for example, sodium lauryl sulfate, sodium lauroyl sarcosine,
Examples thereof include sodium alkyl sulfosuccinate, coconut oil fatty acid monoglycerin sodium sulfonate, and sucrose fatty acid ester. As the binder, xanthan gum,
Carrageenan, sodium carboxymethylcellulose, hydroxyethylcellulose and the like can be mentioned, and as the polishing agent, silicic anhydride and the like can be mentioned.
【００１４】本発明口腔用組成物の形態は、キシリトー
ルを溶解状態で配合するものであることから、洗口剤、
液体歯磨剤等の液状；又は練歯磨剤等のペースト状が好
ましい。[0014] The form of the oral composition of the present invention contains xylitol in a dissolved state.
A liquid such as a liquid dentifrice; or a paste such as a toothpaste is preferred.
【００１５】[0015]
【実施例】次に実施例を挙げて本発明を更に詳細に説明
するが、本発明は以下の実施例に限定されるものではな
い。Next, the present invention will be described in more detail by way of examples, but the present invention is not limited to the following examples.
【００１６】実施例１〜４、比較例１〜３ 表１に示す原料を水に添加し、攪拌して洗口剤を製造し
た。Examples 1 to 4 and Comparative Examples 1 to 3 The raw materials shown in Table 1 were added to water and stirred to produce mouthwashes.
【００１７】各洗口液をスクリューキャップ付き透明Ｐ
ＥＴボトル（３００ml容量）に入れた。キャップに溶液
を約１０ml入れ、洗口後、キャップを軽く振ってからキ
ャップをしめた。室温で１週間保存後、各洗口液の溶液
の性状及びキャップ内部の結晶の付着状態を観察し、以
下の基準で評価した。[0017] Each mouthwash is transferred to a transparent P with a screw cap.
Placed in an ET bottle (300 ml capacity). About 10 ml of the solution was placed in the cap, and after washing the mouth, the cap was shaken gently and then closed. After storage at room temperature for one week, the properties of each mouthwash solution and the attached state of crystals inside the cap were observed and evaluated according to the following criteria.
【００１８】（評価基準） （１）溶液の性状 ○：結晶が析出していない △：結晶がわずかに析出している ×：結晶が多く析出している （２）キャップの内部 ○：結晶が付着していない △：結晶がわずかに付着している ×：結晶が多く付着している(Evaluation Criteria) (1) Properties of Solution ：: No Crystals Precipitated Δ: Slight Crystals Precipitated X: Many Crystals Precipitated (2) Inside of Cap ○: Crystals Precipitated Not attached △: Slightly attached crystals ×: Many attached crystals
【００１９】[0019]
【表１】 [Table 1]
【００２０】その結果、本発明の洗口液はキシリトール
の結晶析出抑制効果が顕著であり、品質安定性がよく、
実使用時にキャップの汚れが少ないことが判明した。As a result, the mouthwash of the present invention has a remarkable effect of suppressing the crystal deposition of xylitol, has good quality stability,
It was found that the cap was less soiled during actual use.
【００２１】実施例５〜９ 表２に示す組成の歯磨剤を製造し、３ケ月間保存したと
ころ、キシリトール結晶の析出は観察されなかった。Examples 5 to 9 When dentifrices having the compositions shown in Table 2 were prepared and stored for 3 months, no precipitation of xylitol crystals was observed.
【００２２】[0022]
【表２】 [Table 2]
【００２３】[0023]
【発明の効果】本発明の口腔用組成物は多量のキシリト
ールを配合しても結晶析出がなく長期間安定である。As described above, the oral composition of the present invention is stable for a long time without crystal precipitation even when a large amount of xylitol is blended.
Claims (5)
外の糖アルコールが、ソルビトール及び／又はマルチト
ールである請求項１記載の口腔用組成物。2. The oral composition according to claim 1, wherein the sugar alcohol other than xylitol in the sugar alcohol mixture is sorbitol and / or maltitol.
２００〜１０００の範囲である請求項１又は２記載の口
腔用組成物。3. The oral composition according to claim 1, wherein the polyethylene glycol has an average molecular weight in the range of 200 to 1,000.
１：５〜５：１の範囲である請求項１〜３のいずれか１
項記載の口腔用組成物。4. A sugar alcohol mixture: water (by weight)
4. The method according to claim 1, wherein the ratio is in the range of 1: 5 to 5: 1.
The oral composition according to the above item.
性アルカリ土類金属塩類から選ばれる１種又は２種以上
を含有する請求項１〜４のいずれか１項記載の口腔用組
成物。5. The oral composition according to claim 1, further comprising one or more selected from water-soluble alkali metal salts and water-soluble alkaline earth metal salts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01106298A JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01106298A JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11209253A true JPH11209253A (en) | 1999-08-03 |
| JP3983874B2 JP3983874B2 (en) | 2007-09-26 |
Family
ID=11767526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP01106298A Expired - Lifetime JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3983874B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012133757A1 (en) * | 2011-03-31 | 2012-10-04 | 日本クラフトフーズ株式会社 | Flowable food composition and confection |
-
1998
- 1998-01-23 JP JP01106298A patent/JP3983874B2/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012133757A1 (en) * | 2011-03-31 | 2012-10-04 | 日本クラフトフーズ株式会社 | Flowable food composition and confection |
| JPWO2012133757A1 (en) * | 2011-03-31 | 2014-07-28 | モンデリーズ・ジャパン株式会社 | Fluid food composition and confectionery |
| JP5956428B2 (en) * | 2011-03-31 | 2016-07-27 | モンデリーズ・ジャパン株式会社 | Fluid food composition and confectionery |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3983874B2 (en) | 2007-09-26 |
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