JP3983874B2 - Oral composition - Google Patents
Oral composition Download PDFInfo
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- JP3983874B2 JP3983874B2 JP01106298A JP1106298A JP3983874B2 JP 3983874 B2 JP3983874 B2 JP 3983874B2 JP 01106298 A JP01106298 A JP 01106298A JP 1106298 A JP1106298 A JP 1106298A JP 3983874 B2 JP3983874 B2 JP 3983874B2
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- Prior art keywords
- weight
- xylitol
- composition
- water
- oral cavity
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【０００１】
【発明の属する技術分野】
本発明はキシリトール結晶の析出が抑制された口腔用組成物に関する。
【０００２】
【従来の技術】
従来よりキシリトールはむし歯になりにくい糖アルコールとして知られており、洗口剤、練歯磨剤等の口腔用組成物にも使用されてきた。かかるキシリトールの効果を充分に奏させるためには、キシリトールの濃度を高くする必要がある。
【０００３】
しかしながら、キシリトールの水に対する溶解度は２５℃で６４（ｇ／１００ｇ）であり、キシリトールを口腔用組成物に溶解状態で配合しようとする場合、高濃度に配合すると結晶が析出し、均質な性状を保つことができないため、その配合量には制限があった。そこで、キシリトールの結晶化を抑制するため、マルチトール、ソルビトール、マンニトール、グリセリン等の多価アルコールを一定比率で配合する方法が知られている（米国特許第５１４４０２４号）。
【０００４】
【発明が解決しようとする課題】
ところが、その結晶化防止手段は、未だ充分でなく、更に多量のキシリトールを溶解状態で配合できる口腔用組成物の開発が求められていた。
従って、本発明の目的は、キシリトールを高濃度に含有しても結晶析出がなく、安定な口腔用組成物を提供することにある。
【０００５】
【課題を解決するための手段】
そこで本発明者は上記課題を解決すべく種々検討してきたところ、キシリトールに加えてキシリトール以外の糖アルコールを配合し、更にポリエチレングリコールを一定量配合すれば、キシリトールを高濃度に含有しても結晶析出がなく、長期間安定な口腔用組成物が得られることを見出し、本発明を完成するに至った。
【０００６】
すなわち、本発明は、次の成分（ａ）、（ｂ）及び（ｃ）：
（ａ） キシリトールと、ソルビトール及び／又はマルチトールとから成り、糖アルコール混合物中７０〜９０重量％のキシリトールを含有する糖アルコール混合物
３０〜６０重量％
（ｂ） ポリエチレングリコール ４〜８重量％
（ｃ） 水 ５〜６６重量％
を含有する口腔用組成物を提供するものである。
【０００７】
【発明の実施の形態】
本発明に用いられる成分（ａ）は、キシリトールを含有する糖アルコール混合物であり、当該糖アルコール混合物中キシリトールを５０〜９０重量％含有する。糖アルコール中のキシリトール含量が５０重量％未満の場合には、キシリトール配合によるむし歯になりにくいという効果が充分でなく、またキシリトール含量が９０重量％を超えるとキシリトール結晶が析出しやすくなるので好ましくない。当該糖アルコール混合物中の好ましいキシリトール含量は６０〜９０重量％であり、特に好ましいキシリトール含量は７０〜９０重量％である。
【０００８】
成分（ａ）中のキシリトール以外の糖アルコールとしては、ソルビトール、マルチトール、マンニトール、パラチニトール、ラクチトール等が挙げられるが、キシリトールの結晶析出防止性の点からソルビトール及び／又はマルチトールが好ましい。
【０００９】
当該成分（ａ）の口腔用組成物への配合量は５〜８０重量％であるが、１０〜７０重量％、特に２０〜６０重量％が好ましい。この配合量が５重量％未満ではキシリトール配合による効果が充分得られず、一方８０重量％を超えるとキシリトールの結晶が析出しやすくなるので好ましくない。
【００１０】
成分（ｂ）のポリエチレングリコールは、キシリトール結晶析出防止効果を有するものであり、その平均分子量としては２００〜１０００が好ましい。また、ポリエチレングリコールの口腔用組成物への配合量は２〜２０重量％であるが、３〜１２重量％、特に４〜８重量％が好ましい。この配合量が２重量％未満では充分なキシリトール結晶析出防止効果が得られず、２０重量％を超えると苦みが強くなるので好ましくない。
【００１１】
本発明口腔用組成物には、水を５〜９０重量％配合されるが、口腔用組成物の形態が洗口剤、水性歯磨剤等の液状の場合には４０〜８０重量％が好ましく、練歯磨剤等のペースト状の場合には２０〜６０重量％が好ましい。水が５重量％未満の場合には、キシリトールを溶解状態にできず、９０重量％を超えると他の成分の配合量を制限するので好ましくない。
【００１２】
また、本発明口腔用組成物においては、水溶性アルカリ金属塩類又は水溶性アルカリ土類金属塩類を配合することにより、キシリトールの結晶析出防止効果を更に向上させることができる。これらの水溶性塩類としては、無機酸の塩又は炭素数１〜６の有機酸の塩が好ましく、より具体的には、水溶性アルカリ金属塩類としては、例えば、塩化ナトリウム、炭酸水素ナトリウム、リン酸カリウム等が挙げられ、水溶性アルカリ土類金属塩類としては、塩化カルシウム、乳酸カルシウム、硫酸マグネシウム等が挙げられる。かかる水溶性塩類の口腔用組成物への配合量は、特に制限されないが、０．０５〜４０重量％、特に０．１〜２０重量％が好ましい。
【００１３】
更に本発明口腔用組成物には、上記成分に加えて、必要に応じて種々の成分、例えば、発泡剤、粘結剤、抗菌剤、研磨剤、フッ素化合物、香料、他の甘味料、湿潤剤、着色剤、保存剤、薬効成分等を配合することができる。ここで、発泡剤としては、例えば、ラウリル硫酸ナトリウム、ラウロイルサルコシンナトリウム、アルキルスルホコハク酸ナトリウム、ヤシ油脂肪酸モノグリセリンスルホン酸ナトリウム、ショ糖脂肪酸エステル等が挙げられる。粘結剤としては、キサンタンガム、カラギーナン、カルボキシメチルセルロースナトリウム、ヒドロキシエチルセルロース等が挙げられ、研磨剤としては無水ケイ酸等が挙げられる。
【００１４】
本発明口腔用組成物の形態は、キシリトールを溶解状態で配合するものであることから、洗口剤、液体歯磨剤等の液状；又は練歯磨剤等のペースト状が好ましい。
【００１５】
【実施例】
次に実施例を挙げて本発明を更に詳細に説明するが、本発明は以下の実施例に限定されるものではない。
【００１６】
実施例１〜４、比較例１〜３
表１に示す原料を水に添加し、攪拌して洗口剤を製造した。
【００１７】
各洗口液をスクリューキャップ付き透明ＰＥＴボトル（３００ml容量）に入れた。キャップに溶液を約１０ml入れ、洗口後、キャップを軽く振ってからキャップをしめた。室温で１週間保存後、各洗口液の溶液の性状及びキャップ内部の結晶の付着状態を観察し、以下の基準で評価した。
【００１８】
（評価基準）
（１）溶液の性状
○：結晶が析出していない
△：結晶がわずかに析出している
×：結晶が多く析出している
（２）キャップの内部
○：結晶が付着していない
△：結晶がわずかに付着している
×：結晶が多く付着している
【００１９】
【表１】
その結果、本発明の洗口液はキシリトールの結晶析出抑制効果が顕著であり、品質安定性がよく、実使用時にキャップの汚れが少ないことが判明した。
【００２１】
実施例５〜９
表２に示す組成の歯磨剤を製造し、３ケ月間保存したところ、キシリトール結晶の析出は観察されなかった。
【００２２】
【表２】
【発明の効果】
本発明の口腔用組成物は多量のキシリトールを配合しても結晶析出がなく長期間安定である。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a composition for oral cavity in which precipitation of xylitol crystals is suppressed.
[0002]
[Prior art]
Conventionally, xylitol has been known as a sugar alcohol that does not easily become a cavity, and has been used in oral compositions such as mouthwashes and toothpastes. In order to sufficiently exhibit the effect of xylitol, it is necessary to increase the concentration of xylitol.
[0003]
However, the solubility of xylitol in water is 64 (g / 100 g) at 25 ° C. When xylitol is to be blended in the oral composition in a dissolved state, crystals are precipitated when blended at a high concentration, resulting in a homogeneous property. Since the amount could not be maintained, the amount of the compound was limited. Therefore, a method of blending polyhydric alcohols such as maltitol, sorbitol, mannitol, glycerin, etc. at a constant ratio in order to suppress crystallization of xylitol is known (US Pat. No. 5,144,024).
[0004]
[Problems to be solved by the invention]
However, the means for preventing crystallization is not yet sufficient, and there has been a demand for the development of an oral composition that can contain a larger amount of xylitol in a dissolved state.
Accordingly, an object of the present invention is to provide a stable composition for oral cavity which does not cause crystal precipitation even when xylitol is contained in a high concentration.
[0005]
[Means for Solving the Problems]
Therefore, the present inventor has made various studies to solve the above-mentioned problems. When a sugar alcohol other than xylitol is blended in addition to xylitol and a certain amount of polyethylene glycol is blended, crystals can be obtained even if xylitol is contained in a high concentration. The inventors have found that a composition for oral cavity that is stable for a long period of time without precipitation can be obtained, and the present invention has been completed.
[0006]
That is, the present invention comprises the following components (a), (b) and (c):
(A) a sugar alcohol mixture comprising xylitol and sorbitol and / or maltitol and containing 70 to 90% by weight of xylitol in the sugar alcohol mixture;
30-60% by weight
(B) Polyethylene glycol 4-8% by weight
(C) 5 to 66% by weight of water
The composition for oral cavity containing this is provided.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
The component (a) used in the present invention is a sugar alcohol mixture containing xylitol, and contains 50 to 90% by weight of xylitol in the sugar alcohol mixture. When the xylitol content in the sugar alcohol is less than 50% by weight, the effect of being difficult to become a cavity due to xylitol blending is not sufficient, and when the xylitol content exceeds 90% by weight, xylitol crystals tend to precipitate, which is not preferable. . The preferable xylitol content in the sugar alcohol mixture is 60 to 90% by weight, and the particularly preferable xylitol content is 70 to 90% by weight.
[0008]
Examples of sugar alcohols other than xylitol in component (a) include sorbitol, maltitol, mannitol, paratinitol, lactitol and the like, and sorbitol and / or maltitol are preferred from the viewpoint of preventing crystal precipitation of xylitol.
[0009]
The blending amount of the component (a) in the composition for oral cavity is 5 to 80% by weight, preferably 10 to 70% by weight, particularly preferably 20 to 60% by weight. If the blending amount is less than 5% by weight, the effect of the xylitol blending cannot be sufficiently obtained. On the other hand, if the blending amount exceeds 80% by weight, xylitol crystals tend to precipitate, which is not preferable.
[0010]
The component (b) polyethylene glycol has an effect of preventing xylitol crystal precipitation, and its average molecular weight is preferably 200 to 1,000. Moreover, although the compounding quantity to the composition for oral cavity of polyethyleneglycol is 2 to 20 weight%, 3 to 12 weight%, especially 4 to 8 weight% are preferable. If the blending amount is less than 2% by weight, a sufficient effect of preventing precipitation of xylitol crystals cannot be obtained, and if it exceeds 20% by weight, the bitterness becomes strong, which is not preferable.
[0011]
The oral composition of the present invention contains 5 to 90% by weight of water, but 40 to 80% by weight is preferable when the oral composition is in a liquid form such as a mouthwash or an aqueous dentifrice. In the case of a paste such as a toothpaste, it is preferably 20 to 60% by weight. When water is less than 5% by weight, xylitol cannot be dissolved, and when it exceeds 90% by weight, the amount of other components is limited, which is not preferable.
[0012]
Moreover, in the composition for oral cavity of this invention, the crystal precipitation prevention effect of a xylitol can further be improved by mix | blending water-soluble alkali metal salts or water-soluble alkaline-earth metal salts. These water-soluble salts are preferably inorganic acid salts or organic acid salts having 1 to 6 carbon atoms, and more specifically, water-soluble alkali metal salts include, for example, sodium chloride, sodium hydrogen carbonate, phosphorus Examples of the water-soluble alkaline earth metal salts include calcium chloride, calcium lactate, and magnesium sulfate. The blending amount of such water-soluble salts in the oral composition is not particularly limited, but is preferably 0.05 to 40% by weight, particularly preferably 0.1 to 20% by weight.
[0013]
Furthermore, the oral cavity composition of the present invention includes various components as necessary in addition to the above components, such as foaming agents, binders, antibacterial agents, abrasives, fluorine compounds, fragrances, other sweeteners, moisturizers. Agents, colorants, preservatives, medicinal ingredients, and the like can be blended. Here, examples of the foaming agent include sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, and sucrose fatty acid ester. Examples of the binder include xanthan gum, carrageenan, sodium carboxymethyl cellulose, and hydroxyethyl cellulose. Examples of the abrasive include anhydrous silicic acid.
[0014]
Since the form of the composition for oral cavity of the present invention contains xylitol in a dissolved state, it is preferably a liquid such as a mouthwash or a liquid dentifrice; or a paste such as a toothpaste.
[0015]
【Example】
EXAMPLES Next, although an Example is given and this invention is demonstrated further in detail, this invention is not limited to a following example.
[0016]
Examples 1-4, Comparative Examples 1-3
The raw materials shown in Table 1 were added to water and stirred to produce a mouthwash.
[0017]
Each mouthwash was placed in a transparent PET bottle with a screw cap (300 ml capacity). About 10 ml of the solution was placed in the cap, and after rinsing, the cap was lightly shaken and then the cap was tightened. After storage at room temperature for 1 week, the properties of each mouthwash solution and the attached state of crystals inside the cap were observed and evaluated according to the following criteria.
[0018]
(Evaluation criteria)
(1) Properties of the solution ○: No crystals are deposited Δ: Crystals are slightly deposited ×: Many crystals are deposited (2) Inside the cap ○: No crystals are attached Δ: Crystals ×: A lot of crystals are attached.
[Table 1]
As a result, it has been found that the mouthwash of the present invention has a remarkable effect of suppressing crystal precipitation of xylitol, has good quality stability, and has little dirt on the cap during actual use.
[0021]
Examples 5-9
When the dentifrice of the composition shown in Table 2 was produced and stored for 3 months, no xylitol crystal precipitation was observed.
[0022]
[Table 2]
【The invention's effect】
The oral composition of the present invention is stable for a long time without crystal precipitation even when a large amount of xylitol is added.
Claims (5)
（ａ） キシリトールと、ソルビトール及び／又はマルチトールとから成り、糖アルコール混合物中７０〜９０重量％のキシリトールを含有する糖アルコール混合物
３０〜６０重量％
（ｂ） ポリエチレングリコール ４〜８重量％
（ｃ） 水 ５〜６６重量％
を含有する口腔用組成物。The following components (a), (b) and (c):
(A) a sugar alcohol mixture comprising xylitol and sorbitol and / or maltitol and containing 70 to 90% by weight of xylitol in the sugar alcohol mixture;
30-60% by weight
(B) Polyethylene glycol 4-8% by weight
(C) 5 to 66% by weight of water
The composition for oral cavity containing this.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01106298A JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP01106298A JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11209253A JPH11209253A (en) | 1999-08-03 |
| JP3983874B2 true JP3983874B2 (en) | 2007-09-26 |
Family
ID=11767526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP01106298A Expired - Lifetime JP3983874B2 (en) | 1998-01-23 | 1998-01-23 | Oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3983874B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012133757A1 (en) * | 2011-03-31 | 2012-10-04 | 日本クラフトフーズ株式会社 | Flowable food composition and confection |
-
1998
- 1998-01-23 JP JP01106298A patent/JP3983874B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11209253A (en) | 1999-08-03 |
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