JPH11158489A - Amidoamine oxide compound-containing irritation-relieving agent for surfactant - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a surfactant compsn. which can relieve protein modification phenomena by incorporating a plurality of quaternary nitrogen-contg. cationic surface active compds. and an amine oxide compd.-contg. irritation-relieving agent for surfactants in a specified molar amt. (based on the sum of foregoing compds.) into the same. SOLUTION: This surfactant compsn. contains quaternary nitrogen-contg. cationic surface active compds. represented by formulas I and II [e.g. mono-(12-18C)-alkyltrimethylammonium and di-(12-18C)-alkyldimethylammonium chlorides] and an irritation-relieving agent contg. lauramidopropyldimethylamine oxide represented by formula III in an amt. of at least 0.7 times mol based on the sum of the foregoing compds. In the formulas I and II, R<4> , R<8> , and R<9> are each a 12-20C alkyl; R<7> is H, 1-2C alkyl, benzyl, or the like; R<10> and R<11> are each H, a 1-20C alkyl, or the like; and X is a counter anion. In the formula III, R<1> is a 7-21C alkyl or alkenyl; R<2> and R<3> are each a 1-5C alkyl or alkenyl; and n is an integer of 1-5.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stimulant for surfactants which does not impair the intrinsic properties of the surfactant, and a surfactant composition containing the same, and particularly to quaternary nitrogen. The present invention relates to a stimulant for a surfactant capable of alleviating a protein denaturation phenomenon caused by the quaternary nitrogen-containing surfactant without impairing the bactericidal activity of the surfactant containing the surfactant, and a surfactant composition containing the same. Things.

[0002]

2. Description of the Related Art Quaternary nitrogen-containing surfactant compounds belong to cationic surfactants in the category of surfactants. Since this compound has a positive charge in the molecule, it is often used as a hair rinse agent or the like that utilizes high adsorptivity to hair. It is also generally known that cationic active compounds have bactericidal activity. For example, a so-called inverse soap such as a benzalkonium chloride solution is widely used as a germicidal detergent. However, a composition containing a cationic compound, such as an inverse soap, is a detergent with strong skin irritation, and it has been inevitable that the skin becomes rough due to long-term use. This is believed to be because the cationic surfactant is so stimulating that it denatures the protein. This means that, for example, when a cationic compound-containing composition such as an inverse soap, a hair rinse, or a hand soap, or a cationic compound alone is added to egg white, the water-soluble protein in the egg white is denatured and becomes cloudy or white. It can be easily estimated from the phenomenon of solidification. This protein denaturation is a phenomenon that is often observed not only with cationic surfactants but also with some anionic surfactants, particularly sulfur-containing surfactants. It is already known that the protein denaturation of anionic surfactants is mitigated by adding amphoteric surfactants. However, even when these substances having a stimulating action are added to a cationic surfactant, no stimulating action for protein denaturation is observed. That is, an effective protein denaturing agent for a cationic surfactant has not been found yet.

[0003]

DISCLOSURE OF THE INVENTION The present invention relates to a stimulant for surfactants which can alleviate the protein denaturation of cationic surfactants without impairing the original effects of the cationic surfactants, such as bactericidal activity. It is intended to provide a surfactant composition containing the same.

[0004]

Means for Solving the Problems The present inventors have found that an amidoamine oxide compound having a specific structure has a stimulant relieving action of a surfactant, and in particular, an amidoamine oxide compound is compounded with a cationic surfactant. In this case, it has been found that the irritancy can be reduced without reducing the bactericidal activity of the cationic surfactant.
In addition, the present inventors have found that the amidoamine oxide compound is effective not only in reducing the irritation to the cationic surfactant, but also in solubilizing the complex of the cationic surfactant and the anionic surfactant. To improve the foaming and detergency of this complex. The present invention has been completed based on the above findings.

The stimulant for surfactants of the present invention has the following general formula (1):

Embedded image [In the formula (1), R ¹ represents a hydroxyl-substituted or unsubstituted alkyl group or alkenyl group having 7 to 21 carbon atoms, and R ² and R ³ each independently represent a carbon atom. The number represents a hydroxyl group-substituted or unsubstituted alkyl group or alkenyl group having 1 to 5, and n represents an integer of 1 to 5. ] It is characterized by containing the amidoamine oxide compound represented by these. Further, the stimulant-containing surfactant of the present invention contains the stimulant for surfactant and a surfactant, wherein the surfactant is represented by the following general formulas (2) and (3):

Embedded image [However, in the formulas (2) and (3), R ⁴ has 1 carbon atom.
2-20 linear or branched alkyl groups;
⁵ and R ⁶ each independently represent a hydrogen atom or an alkyl group having 1 to 2 carbon atoms or a hydroxyalkyl group, and R ⁷ represents a hydrogen atom or an alkyl group having 1 to 2 carbon atoms. R ⁸ and R ⁹ each independently represent a straight-chain or branched-chain alkyl group having 12 to 20 carbon atoms, and R ¹⁰ and R ¹¹ Are each independently a hydrogen atom or an alkyl group or a hydroxyalkyl group having 1 to 20 carbon atoms, and X represents a counter anion] of the quaternary nitrogen-containing cationic surfactant compound represented by At least one kind, wherein the content of the surfactant stimulant is 0.7 times or more the total content of the quaternary nitrogen-containing cationic surfactant compound.
In the surfactant composition containing a stimulant-relieving agent of the present invention, the surfactant may be an alkylbenzene in addition to at least one of the quaternary nitrogen-containing cationic surfactant compounds of the formulas (2) and (3). A sulfonate, an alkyl sulfate, and an alkyl ether sulfate, further containing at least one anionic surfactant compound, wherein the surfactant stimulant is contained in the quaternary nitrogen-containing cationic surfactant It may be 0.7 times or more the total content of the compound and the anionic surfactant compound.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The irritation-relieving agent of the present invention or a surfactant composition containing the same is provided by an inverse soap, a hair rinse,
It can be applied to a composition containing a cationic surfactant such as a hair conditioner and a hand soap. When the surfactant composition of the present invention is used as a detergent, other anionic surfactants, nonionic surfactants, and amphoteric surfactants are blended to enhance foaming and enhance detergency. It is possible to do. To achieve the alleviation of egg white denaturation which is the effect of the present invention, a quaternary nitrogen-containing cationic surfactant, the total amount of a protein-modified anionic surfactant, an amidoamine oxide compound and a betaine-type amphoteric surfactant It is preferable that the total amount with the compound is within a specific range.

When the stimulant of the present invention is applied to a surfactant containing one or more quaternary nitrogen-containing cationic surfactant compounds of the formulas (2) and / or (3), the formula (2) And / or 0.7 times or more moles of the stimulant-releasing agent of the present invention with respect to at least one mole content of the quaternary nitrogen-containing cationic surfactant compound (3), preferably 1.0 to 1 mole. It is used at a content of 0.5 mol. Addition of less than 0.7 times the molar amount of the stimulant-releasing agent does not impair the bactericidal activity and other properties of the cationic surfactant-containing surfactant, but the effect of alleviating egg white degeneration is insufficient. There is no particular upper limit for the content of the stimulant, but if used in an excessively large amount, the emulsion stability of the emulsion containing the cationic surfactant compound may decrease.

Although the mechanism of the stimulative relaxation action of the amidoamine oxide compound of the formula (1) of the present invention has not been sufficiently elucidated, the amidoamine oxide compound forms a weakly electrostatically associated state with a cationic surfactant. It is presumed that the direct contact between the cationic surfactant and the protein was weakened. This property is a property not found in an alkylamine oxide having an amine oxide site capable of electrostatic association, like the amidoamine oxide of the formula (1), and a property unique to the amidoamine oxides. It is. It has been confirmed by practical tests that this weak association state does not impair the bactericidal action of the cation.

Various structures have been proposed for the cationic surfactant for the purpose of reducing the irritation of the active agent itself. Here, these are referred to as hypoallergenic cations. As the hypoallergenic cation, for example, the following formula (4)
(For example, manufactured by Sanyo Kasei Kogyo Co., Ltd., trademark: Cation LQ); and a cation compound having a structure represented by formula (5) (for example, manufactured by Ajinomoto Co., Ltd., trademark: CAE), and A cationic compound having a structure represented by the formula (6) (for example, Ajinomoto Co., Inc.)
(Trademark: Amisafe) and the like.

[0010]

Embedded image It is considered that the amidoamine oxide compound of the formula (1) also forms a weak association state with the low-stimulant cationic compounds of the formulas (4), (5) and (6), and exhibits a stimulus-reducing effect. Further, since these low-irritating cationic compounds generally have a weaker amount of adsorption to hair and the like than quaternary nitrogen-containing cations, they often leave some problems in the usability when formulated during rinsing. By blending the amidoamine oxide compound of the formula (1) with the hypoallergenic cation, a weak association state intervenes between the two, and when the amidoamine oxide compound is blended with the hypoallergenic cation, the feeling of use can be changed. It has been confirmed by practical tests that the rinsing feeling can be further increased.

The stimulant or surfactant composition of the present invention comprises an inverse soap, a hair rinse, a hair conditioner,
It can be applied to a composition containing a cationic surfactant such as a hand soap. When this is used as a detergent composition, other anionic surfactants, nonionic surfactants and / or amphoteric surfactants are blended for the purpose of enhancing foam and enhancing detergency. Things are possible. At this time, betaine amide acetate or the like used as an amphoteric surfactant has a stimulant-relaxing effect on anions. Therefore, in utilizing the present invention, the minimum molar concentration of the amidoamine oxide compound of the formula (1) is determined by the following formula. Can be calculated. The number of moles of amidoamine oxide = 0.7 × [the number of moles of cation + (the number of moles of anion−the number of amphoteric moles)] In order to realize the alleviation of egg white degeneration, which is the effect of the present invention,
The total amount of the quaternary nitrogen-containing cationic surfactant and the anion having a protein denaturing effect and the total amount of the amidoamine oxide and the betaine-type amphoteric surfactant are appropriately blended so as to be within the range described in the present invention. I just need.

When preparing the surfactant composition of the present invention,
A quaternary nitrogen-containing cationic surfactant compound of the formula (2)
The thing C from the availability₁₂~ C₁₈Alkyl tri
Methyl ammonium chloride, Mono C₁₂~ C₂₀Archi
Dimethylbenzylammonium chloride
Can be Also, a quaternary nitrogen-containing cation of the formula (3)
Di-active compounds include di-C₁₂~ C ₁₈Alkyl dime
Thilammonium chloride, dioleyl dimethylan
Monium chloride and dialkyl (tallow) dimethyl
And ammonium chloride.

The amidoamine oxide compounds of the formula (1) used as the stimulant relieving agent of the present invention include, specifically, amidopropyldimethylamine oxide laurate, amidopropyldimethylamine oxide myristate, and amidepropyldimethylamine oxide coconut fatty acid. And the like.

The surfactant composition of the present invention contains a fragrance, a coloring agent, a pearl agent, a polymer thickener, a conditioning agent, a humectant, an oil agent, a preservative, A hydrotrope agent, an ultraviolet absorber or the like may be optionally added.

The surfactant composition of the present invention has the formula (2)
In addition to the quaternary nitrogen-containing cationic interface compound of (3), an anionic surfactant compound may be contained. Such anionic surfactants include alkyl benzene sulphonates (such as linear dodecyl benzene sulphonate and dodecyl benzene polyoxyethylene ether sulphonate), alkyl sulphates (such as polyoxyethylene lauryl sulphate and polyoxy sulphate). Ethylene myristyl sulfate),
And alkyl ether sulfates (eg, polyoxyethylene lauryl ether sulfate, polyoxyethylene polypropylene copolymerized lauryl ether sulfate, etc.). Equation (2)
And / or when the anionic surfactant compound is mixed with the quaternary nitrogen-containing cationic surfactant compound of (3), these compounds are ionically bonded to form a complex. In the presence of the (1) amidoamine oxide compound, it shows water solubility and can be stably present in the composition.

The content of the anionic surfactant compound is preferably in a ratio of 2: 8 to 8: 2 with respect to the content of the quaternary nitrogen-containing cationic surfactant compound of the formula (2) and / or (3). Preferably, more preferably 3: 7 to 7: 3.
In this case, the resulting cationic and anionic surfactant compound complex can significantly improve the cleaning effect.

The surfactant of the surfactant composition containing a stimulant-releasing agent of the present invention may further comprise, in addition to the quaternary nitrogen-containing cationic surfactant of formula (2) and / or (3), a nonionic surfactant. Compounds (eg, polyoxyethylene lauryl ether, polyoxyethylene sorbitan ester, fatty acid alkanolamide, polyoxyethylene fatty acid alkanolamide, etc.) and amphoteric surface active compounds (eg, lauryl acetate betaine, lauramidopropyl acetate betaine, and lauramidopropyl hydroxy) Sulfobetaine, etc.). In the surfactant composition of the present invention, the nonionic surfactant compound and the amphoteric surfactant compound exhibit actions such as foaming power, detergency, and liquid viscosity adjustment of the surfactant composition.

In particular, when the surfactant of the surfactant composition of the present invention contains a quaternary nitrogen-containing cationic surfactant of the formula (2) and / or (3) and an anionic surfactant,
It is possible to use a combination of a betaine-type amphoteric surfactant and an alkylamine oxide, which are known anion stimulants. Since the egg white denaturation of the quaternary nitrogen-containing cationic surfactant is alleviated only by the amidoamine oxide compound, the quaternary nitrogen-containing cationic surfactant is 0.7 times or more the molar amount of the cationic surfactant containing the amidoamine oxide compound. A quaternary nitrogen-containing cationic surfactant is prepared by blending an amidoamine oxide compound in an amount of 0.7 times or more the total number of moles of a surfactant and an anionic surfactant with a betaine-type amphoteric surfactant and an alkylamine oxide. And an anionic surfactant complex can be dissolved to achieve the alleviation of egg white degeneration.

The amidoamine oxide compound of the formula (1) of the present invention can be produced by oxidizing the corresponding amidoamine with an oxidizing agent such as hydrogen peroxide.

[0020]

The present invention will be described below with reference to examples and comparative examples, but the scope is not limited thereto. In the following Examples, the stimulus value of the test surfactant composition was evaluated by the following egg white denaturation test.

Egg white denaturation test Egg white of chicken eggs was separated and uniformly stirred to the extent that air bubbles were not involved. Karaza and other insoluble substances were removed by filtration through a 50-mesh wire mesh to obtain uniform egg white. Next, add 5 of this egg white
In a 0 g beaker, a sample to be subjected to a stimulation test was added and stirred. Thereafter, the mixture was allowed to stand, and after 2 minutes, an L value proportional to the amount of transmitted light was read by a colorimeter.
The L value of the test sample-free egg white was similarly read, and the stimulus value was calculated by the following equation. Stimulation value = (LB−LS) / LB [where, LB indicates the L value of blank egg white and LS
Indicates the L value of egg white after addition of the sample. ]

Examples 1 to 4 and Comparative Examples 1 to 12 In Examples 1 to 12 and Comparative Examples 1 to 4,
And a surfactant composition having the composition shown in Table 2. In each of these compositions, the amount of lauric amidoamine oxide (LAAO) or laurylamine oxide (LAO) and monostearyltrimethylammonium chloride (MSTA) was varied, but the total amount of monostearyltrimethyl The ammonium chloride (MSTA) content was kept constant at 0.075 g. Tables 1 and 2 show the compositions and stimulus values of the examples and comparative examples. FIG. 1 shows the relationship between the stimulus value and the LAAO mole% value, and FIG. 2 shows the relationship between the stimulus value and the LAO mole% value. Shown in

[0023]

[Table 1]

[0024]

[Table 2]

As apparent from Table 1 and FIG. 1, monostearyltrimethylammonium chloride (MST)
A) to lauric acid amidoamine oxide (LA)
When AO) is added, the effect of alleviating the stimulation by MSTA is exhibited. In particular, when the added amount of LAAO is 0.7 times or more the molar amount of MSTA, the above-mentioned stimulating alleviating effect is remarkably exhibited. On the other hand, as shown in Table 2 and FIG. 2, when laurylamine oxide (LAO) is used instead of LAAO, the cationic interface is close to LAAO despite the fact that the chemical structure of LAO is similar to LAAO. Almost no palliative effect on the irritation of the active agent is observed.

[0026] In each of Examples 5-9 and Comparative Examples 13 to 15 Examples 5 to 9 and Comparative Examples 13 to 15, L
AAO and monomyristyryldimethylbenzylammonium chloride (MMDMBA) were mixed at the composition shown in Table 3 to prepare a surfactant composition, and the stimulus value was measured. Table 3 shows the measurement results.

[0027]

[Table 3]

[0028] In each of Examples 10 to 15 and Comparative Examples 16 to 17 Examples 10 to 15 and Comparative Examples 16-17, and LAAO, a mono palmityl trimethyl ammonium chloride (MPTMA), the composition according to Table 4 To prepare a surfactant composition, and its stimulus value was measured. Table 4 shows the measurement results.

[0029]

[Table 4]

Examples 16 to 33 and Comparative Examples 18 to 26
(Evaluation of sterilizing power) In each of Examples 16 to 33 and Comparative Examples 18 to 26, lauric acid amidoamine oxide (LAAO) was used.
MSTA, MMDMBA, or MPTMA was blended with the composition shown in Table 5 to prepare a surfactant composition.
A sample of each composition was diluted so that the weight concentration of the cationic surfactant therein became the concentration (ppm) shown in Table 5, and bacteria were added to the sample diluent to a concentration of 10 ⁵ to 10 ⁵ .
After inoculating at 10 ⁶ cells / ml and storing at 30 ° C. for 3 days, the viable cell count in each sample diluent was examined by SCDLP or GPLP agar pour method, and no viable cells were detected. The case was considered sterilized.

The fungal species is a fungus from the USP indicator bacterium as a fungus.
albicans, P. as gram-negative bacteria. aerug
inosa, Gram-positive bacteria. aureus was used. Lauric acid amidoamine oxide (L
AAO) was also subjected to the same test. Thus, it was confirmed that lauric acid amidoamine oxide did not inhibit the growth of bacteria even at a concentration of 250 ppm, and thus lauric acid amidoamine oxide had no bactericidal activity. Table 5 shows the results. (In Table 5, ×: no bactericidal effect, ○: bactericidal effect)

[0032]

[Table 5]

Table 5 shows that when the measurement result is judged to be "O", the amidoamine oxide compound of the present invention is added at the minimum concentration of the cationic surfactant compound (that is, the minimum bactericidal concentration (MBC)) or more. Shows no effect on the bactericidal effect of the composition.

[0034] In each of Comparative Examples 27 to 34 and Examples 34 to 41 Comparative Examples 27 to 34 and Examples 34~41, LAAO, MSTA and POE (2) ~POE
(3) -Lauryl ether sulfate (SLES)
Was blended with the compositions shown in Tables 6 and 7 to prepare a surfactant composition, and the above-mentioned irritation test was performed. The compositions of Examples 34 to 41 shown in Table 7 were all transparently dissolved, and the stimulus value was 50% or less. Also, these compositions showed good detergency in the leanut wash test. In Equations 6 and 7, the SLES amount is POE
(2) Calculated as lauryl ether sulfate.

[0035]

[Table 6]

[0036]

[Table 7]

Example 42 A hypoallergenic sterilizing hand soap having the following composition (weight) was prepared. Hypoallergenic sterilizing hand soap prauric acid 5.50% lauric acid amidoamine oxide 30% solution 3.00% benzalkonium chloride 50% solution 1.00% benzethonium chloride 50% solution 0.50% coconut fatty acid diethanolamide 2.50 % Coconut fatty acid imidazolium betaine * 1 10.50% Triethanolamine Amount to make pH = 7.8 Glycerin 3.00% Purified water Amount to make 100% [Note * 1: For example, Softazoline CL (trademark), Kawaken Fine Chemical The above components were mixed, heated to 80 ° C., uniformly dissolved, and then cooled. A homogeneous liquid composition was obtained. In this composition, lauric acid amidoamine oxide (LAA)
The content of O) was about 150 mol% based on the total molar content of the cationic compound. When this hand soap was subjected to an egg whiteness degeneration test, its stimulus value was 15%. In addition, the composition in which LAAO was replaced with purified water caused egg white to aggregate.

Example 43 A hypoallergenic body shampoo having the following composition was prepared. Hypoallergenic body shampoo Palm fatty acid / arginine salt 4.00% Amidoamine oxide laurate 30% solution 15.00% Benzalkonium chloride 50% solution 1.00% Glycerin 3.00% Polyoxyethylene lauryl sodium sulfate 25% 20.00% Lauroyl-β-alanine sodium salt 10.00% Diethanolamine laurate 4.00% Amount to make citric acid pH = 7.5 Disodium EDTA 0.20% Amount to make purified water 100% Mix the above ingredients Then, the mixture was heated to 80 ° C. to dissolve uniformly, and then cooled to obtain a uniform liquid composition. LA in this composition
The content of AO was about 102 mol% based on the total amount of the sulfate and the cation component. When this composition was subjected to an egg whiteness degeneration test, its stimulus value was 10%.

Example 44 A hypoallergenic hair growth rinse having the following composition was prepared. Hypoallergenic hair growth rinse Trimethylstearyl chloride ammonium chloride solution 50% 3.00% A. A. Ethyl lanolin sulfate fatty acid aminopropyl ethyl dimethyl ammonium 65% 1.00% Ester IPM 1.00% A. Cetanol 3.50% A. Grape seed oil 0.50% B. B. lauric amidoamine oxide 30% solution 5.00% Mucopolysaccharide solution * 1 0.10% B. Carrot extract * 2 0.10% B. Assembly extract * 3 0.10% B. Methyl paraben 0.20% B. Amount to be 100% purified water [Note * 1 For example, Falconic mucin (Ichimaru Falcos) * 2 For example, Singhong Guinisin LV (Ichimaru Falcos) * 3 For example, suerutianin (Ichimaru Falcos)] Oil phase component A Each of the aqueous phase component B and the aqueous phase component B was heated to 80 ° C. to uniformly dissolve the same. At 80 ° C., a mixed emulsified acid was added, followed by cooling to obtain a uniform emulsion composition. In this composition, the content of LAAO was about 90% based on the content of the cationic component. When this composition was subjected to an egg whiteness degeneration test, its stimulus value was 35%.

Example 45 and Comparative Example 35 A hypoallergenic anti-fukerin having the following composition was prepared. Hypoallergenic anti-fukerin Example 45 Comparative Example 35 A. N- [3-alkyloxy-2-hydroxypropyl] -L-arginine hydrochloride 60% 2.00% 2.00% A. Trimethylstearyl chloride ammonium chloride solution 50% 1.00% 1.00% A. Octyldodecyl myristate 1.00% 1.00% Cetyl 2-ethylhexanoate 2.00% 2.00% A. Cetanol 3.00% 3.00% A. Behenyl alcohol 1.00% 1.00% A. Egg yolk oil 0.50% 0.50% B. Lauric acid amidoamine oxide 30% solution 5.00% ＢB. Carboxyethyl cellulose 0.10% 0.10% B. EDTA · 2Na 0.10% 0.10% B. Piroctone olamine 0.10% 0.10% B. Glycerin 3.00% 3.00% B. Purified water Amount to be 100% Amount to be 100% Each of the oil phase component A and the aqueous phase component B is heated to 80 ° C. to uniformly dissolve or suspend, and these are mixed and emulsified at 80 ° C. This was cooled to obtain a uniform emulsion composition (Example 45). The content of LAAO in this composition is about 122% based on the total content of the cationic component.
Mole%. When this composition was subjected to an egg whiteness degeneration test, its stimulus value was 23%. Example 45
The composition of Comparative Example 35 in which LAAO was removed from the composition of
The feeling of use as a rinse was poor, and the stimulus value in the egg whitening test increased to 90%.

Example 46 A hypoallergenic hair conditioner having the following composition was prepared. Hypoallergenic hair conditioner A. A. Trimethyl stearyl ammonium chloride solution 50% 1.70% A. Dimethyl distearyl chloride ammonium chloride solution 75% 1.30% Glyceryl monostearate 1.00% A. Macadamia nut oil 3.00% A. Cetanol 3.00% A. Vitamin E oil 0.10% A. Dibutylhydroxytoluene 0.01% B. Palm fatty acid amidoamine oxide 35% 3.00% B. Dipotassium glycyrrhizinate 0.20% B. Glycerin 3.00% B. Amodimethicone 1.00% B. Methyl paraben 0.20% B. Amount of purified water to 100% Each of the oil phase component A and the water phase component B is heated to 80 ° C. to dissolve uniformly, and after mixing and emulsifying them at 80 ° C., the mixture is cooled to obtain a uniform An emulsion composition was obtained. The content of LAAO in this composition was about 82 mol% based on the total content of the cationic components. When this composition was subjected to an egg whiteness degeneration test, its stimulus value was 45%
Met.

Example 47 A mild kitchen detergent having the following composition was prepared. Hypoallergenic kitchen detergent Trimethylstearyl ammonium chloride solution 50% 10.00% SLES 25% 20.00% Palm fatty acid amidoamine oxide 35% solution 35.00% Ethanol 3.00% Propylene glycol 3.00% Methyl paraben 0.20% Purified water Amount to become 100% All other components except ethanol were mixed and heated to 80 ° C to dissolve. After cooling, when the liquid temperature reached 50 ° C, ethanol was added and further cooled. The resulting kitchen detergent contained 142% mol of amidoamine oxide based on the total amount of cations and anions. The kitchen detergent had a leaf nut detergency of 90% or more, and its stimulus value in the egg white denaturation test was 20%.

Example 48 A low-irritant solid detergent composition having the following composition was prepared. Hypoallergenic solid detergent composition N-lauroyl-L-glutamate monosodium 71.00% Myristyldimethylbenzyl ammonium chloride (40%) 7.00% Cetanol 7.00% Lauric acid amidoamine oxide 30% 15.00% All Was charged into a blend mixer to prepare a uniform ragged mixture, which was passed through a three-roll mill three times, and further formed into a detergent bar through an extruder, and formed by a stamping machine. This composition contains about 171% of the total amount of cations.
Contains moles of LAAO. The stimulus value of this composition in the egg white denaturation test was 25%. This composition also
Good stability in mechanical kneading.

[0044]

The stimulant-relaxing agent for surfactants of the present invention exhibits an excellent stimulant-relaxing effect on various surfactants, especially cationic surfactants. It has a low stimulus value and has excellent practicality as a cleaning agent that comes into contact with the human body.

[Brief description of the drawings]

FIG. 1 is a graph showing the moderating effect on the stimulation of monostearyltrimethylammonium chloride by the addition of the lauric acid amidoamine oxide stimulant of the present invention.

FIG. 2 is a graph showing the effect of adding laurylamine oxide on the stimulation of monostearyltrimethylammonium chloride as a comparative example.

Claims (3)

[Claims] 1. The following general formula (1): [In the formula (1), R ¹ represents a hydroxyl-substituted or unsubstituted alkyl group or alkenyl group having 7 to 21 carbon atoms, and R ² and R ³ each independently represent a carbon atom. Represents a hydroxyl-substituted or unsubstituted alkyl or alkenyl group having a number of 1 to 5, wherein n is 1 to 5
Represents an integer. ] A stimulant for a surfactant containing an amidoamine oxide compound represented by the formula: 2. The method according to claim 1, wherein the surfactant comprises a surfactant, and the surfactant comprises the following general formulas (2) and (3): [However, in the formulas (2) and (3), R ⁴ has 12 carbon atoms.
Of 20 represents a straight-chain or branched-chain alkyl group, R ⁵
And R ⁶ each independently represent a hydrogen atom or an alkyl group or a hydroxyalkyl group having 1 to 2 carbon atoms, and R ⁷ represents a hydrogen atom or an alkyl group having 1 to 2 carbon atoms. Or a hydroxyalkyl group or a benzyl group, R ⁸ and R ⁹ each independently represent a linear or branched alkyl group having 12 to 20 carbon atoms, and R ¹⁰ and R ¹¹ represent Independently represents a hydrogen atom or an alkyl group or a hydroxyalkyl group having 1 to 2 carbon atoms, and X represents a counter anion]. A stimulant-containing interface, wherein the content of the surfactant stimulant is 0.7 times or more the total content of the quaternary nitrogen-containing cationic surfactant compound. Activator composition . 3. The method according to claim 1, wherein the surfactant comprises at least one quaternary nitrogen-containing cationic surfactant compound of the formulas (2) and (3),
Alkyl sulfate, and at least one anionic surfactant compound selected from alkyl ether sulfates, wherein the content of the surfactant stimulant is reduced by the quaternary nitrogen-containing cationic surfactant compound and the anion 0.7 of the total content of the hydrophilic surfactant compound
The surfactant composition containing a stimulant-reducing agent according to claim 2, which is at least twice the molar amount.