JPH11127889A - 生化学反応を実施するための方法と装置 - Google Patents
生化学反応を実施するための方法と装置Info
- Publication number
- JPH11127889A JPH11127889A JP10218348A JP21834898A JPH11127889A JP H11127889 A JPH11127889 A JP H11127889A JP 10218348 A JP10218348 A JP 10218348A JP 21834898 A JP21834898 A JP 21834898A JP H11127889 A JPH11127889 A JP H11127889A
- Authority
- JP
- Japan
- Prior art keywords
- chamber
- reaction chamber
- membrane
- liquid
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000005842 biochemical reaction Methods 0.000 title claims abstract description 23
- 230000008569 process Effects 0.000 title abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 94
- 239000012528 membrane Substances 0.000 claims abstract description 63
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 17
- 229920001184 polypeptide Polymers 0.000 claims abstract description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 59
- 238000004519 manufacturing process Methods 0.000 claims description 36
- 239000011888 foil Substances 0.000 claims description 22
- 238000011084 recovery Methods 0.000 claims description 20
- 238000005086 pumping Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 2
- 239000002699 waste material Substances 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims 1
- 239000000047 product Substances 0.000 description 17
- 238000005266 casting Methods 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012526 feed medium Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000005316 response function Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 108020004566 Transfer RNA Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 125000004122 cyclic group Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732935:7 | 1997-07-31 | ||
| DE19732935 | 1997-07-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11127889A true JPH11127889A (ja) | 1999-05-18 |
| JPH11127889A5 JPH11127889A5 (enExample) | 2005-10-06 |
Family
ID=7837440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10218348A Pending JPH11127889A (ja) | 1997-07-31 | 1998-07-31 | 生化学反応を実施するための方法と装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6107055A (enExample) |
| EP (1) | EP0894852B1 (enExample) |
| JP (1) | JPH11127889A (enExample) |
| AT (1) | ATE258592T1 (enExample) |
| DE (2) | DE59810647D1 (enExample) |
| RU (1) | RU2217492C2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670173B1 (en) | 1999-01-27 | 2003-12-30 | Roche Diagnostics Gmbh | Bioreaction module for biochemical reactions |
| RU2169154C2 (ru) | 1999-03-25 | 2001-06-20 | Институт белка РАН | Способ получения полипептидов в бесклеточной системе |
| USD437408S1 (en) | 1999-04-23 | 2001-02-06 | Roche Diagnostics Gmbh | Dialyzer |
| US20040115760A1 (en) * | 1999-06-18 | 2004-06-17 | Thomas Metzler | Method and device for carrying out biochemical reactions with a high throughput |
| ES2229587T3 (es) * | 1999-06-18 | 2005-04-16 | Roche Diagnostics Gmbh | Procedimiento y dispositivo para llevar a cabo reacciones bioquimicas con alto rendimiento. |
| AU2001255521A1 (en) * | 2000-04-21 | 2001-11-07 | University Of Rochester | Biphasic reaction vessel and methods of use |
| CN1219888C (zh) * | 2000-08-29 | 2005-09-21 | 株式会社无细胞科学 | 无细胞蛋白质合成方法 |
| US7390653B2 (en) * | 2002-12-04 | 2008-06-24 | Synthecon, Inc. | Culture chamber for biologicals |
| RU199182U1 (ru) * | 2019-12-10 | 2020-08-19 | Федеральное государственное бюджетное учреждение науки Институт белка Российской академии наук (ИБ РАН) | Устройство для синтеза белков в бесклеточной системе |
| EP4516392A1 (en) * | 2023-09-04 | 2025-03-05 | Vito NV | Peptides, peptidic nucleic acids (pna) and oligonucleotides synthesis assisted by membrane extraction |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984001959A1 (en) * | 1982-11-16 | 1984-05-24 | Univ California | Rapid production of biological products by fermentation in a densely-packed microbial membrane reactor |
| US5135853A (en) * | 1983-07-22 | 1992-08-04 | Rensselaer Polytechnic Institute | Three compartment bioreactor and method of use |
| JPS62500356A (ja) * | 1984-10-09 | 1987-02-19 | エンドトロニツクス インコ−ポレ−テツド | 栄養素の潅流および生成物の濃度を改良した中空繊維培養装置および運転方法 |
| US5478730A (en) * | 1988-12-21 | 1995-12-26 | Institute Of Protein Research | Method of preparing polypeptides in cell-free translation system |
| DE3914956A1 (de) * | 1989-05-06 | 1990-11-22 | Fischer Karl Heinz | Verfahren zur beschleunigung des stoffaustauschs eines kontinuierlichen bioreaktors und vorrichtung zur durchfuehrung dieses verfahrens |
| FR2667874B1 (fr) * | 1990-10-16 | 1992-12-31 | Rhone Alpes Futur Fondation | Reacteur bio-catalyse, et procede de traitement correspondant, applicables notamment a la transformation malolactique du vin. |
| AU2501692A (en) * | 1991-08-09 | 1993-03-02 | Biotec Research & Development, Inc. | Culture and fermentation method and apparatus |
| US5434079A (en) * | 1993-02-12 | 1995-07-18 | The United States Of America As Represented By The Department Of Health And Human Services | Apparatus and process for continuous in vitro synthesis of proteins |
| DE69419095T2 (de) * | 1993-03-09 | 2000-02-03 | Baxter International Inc., Deerfield | Rektifikationsdialysator, membran und bioreaktor |
| FR2707663A1 (fr) * | 1993-07-12 | 1995-01-20 | Carrar | Bioréacteur miniature à renouvellement continu de milieu nutritif. |
-
1998
- 1998-07-17 EP EP98113394A patent/EP0894852B1/de not_active Expired - Lifetime
- 1998-07-17 DE DE59810647T patent/DE59810647D1/de not_active Expired - Fee Related
- 1998-07-17 DE DE19832160A patent/DE19832160A1/de not_active Withdrawn
- 1998-07-17 AT AT98113394T patent/ATE258592T1/de not_active IP Right Cessation
- 1998-07-30 US US09/124,985 patent/US6107055A/en not_active Expired - Fee Related
- 1998-07-30 RU RU98114506/13A patent/RU2217492C2/ru not_active IP Right Cessation
- 1998-07-31 JP JP10218348A patent/JPH11127889A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2217492C2 (ru) | 2003-11-27 |
| EP0894852B1 (de) | 2004-01-28 |
| US6107055A (en) | 2000-08-22 |
| DE59810647D1 (de) | 2004-03-04 |
| EP0894852A3 (de) | 1999-08-18 |
| DE19832160A1 (de) | 1999-02-04 |
| ATE258592T1 (de) | 2004-02-15 |
| EP0894852A2 (de) | 1999-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050516 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050516 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080401 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080930 |