JPH11106322A - Composition for oral cavity - Google Patents
Composition for oral cavityInfo
- Publication number
- JPH11106322A JPH11106322A JP933098A JP933098A JPH11106322A JP H11106322 A JPH11106322 A JP H11106322A JP 933098 A JP933098 A JP 933098A JP 933098 A JP933098 A JP 933098A JP H11106322 A JPH11106322 A JP H11106322A
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- fluorine
- supplying compound
- weight
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は口腔用組成物、さら
に詳しくは歯の再石灰化作用を促進し、安定性に優れた
口腔用組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition, and more particularly to an oral composition which promotes remineralization of teeth and has excellent stability.
【０００２】[0002]
【従来の技術】歯質の主成分はハイドロキシアパタイト
（Ｃａ10（ＰＯ4）6（ＯＨ）2）であり、口中において
は通常、リン酸イオンやカルシウムイオンの溶出（脱
灰）と、リン酸カルシウムやハイドロキシアパタイトへ
の結晶化（再石灰化）が平衡状態にある。ここでムシ歯
の原因菌が産生する酸は、脱灰を促進することが知られ
ている。すなわちムシ歯は、歯垢を構成するストレプト
コッカス・ミュータンス（Streptococcus mutans）等の
細菌がショ糖等を分解して乳酸を主とする有機酸を産生
し、これがｐＨを低下させてカルシウム等を溶出させる
ことにより生じる。ところでムシ歯の初期においては、
通常透明なエナメル質に白斑（ホワイトスポット）が生
じるが、フッ素イオンやカルシウムイオンは再石灰化を
促進することにより、かかる白斑を消失させ、エナメル
質を再透明化することが知られている。2. Description of the Related Art Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) is the main component of tooth material. In the mouth, phosphate ions and calcium ions are generally eluted (decalcified) and calcium phosphate and calcium phosphate are dissolved. Crystallization (remineralization) to hydroxyapatite is in equilibrium. Here, it is known that the acid produced by the causative bacteria of the teeth promotes demineralization. In other words, worms, such as Streptococcus mutans, which make up plaque, break down sucrose and produce organic acids, mainly lactic acid, which lowers the pH and elutes calcium, etc. This is caused by By the way, in the early stage of the worm teeth,
Normally, vitiligo (white spots) are generated in transparent enamel, but it is known that fluoride ions and calcium ions promote remineralization, thereby eliminating such vitiligo and making the enamel re-transparent.
【０００３】しかしながら、フッ素イオンとカルシウム
イオンとを共存させると、フッ化カルシウムの沈澱を生
じてしまい、白斑を消失させることができない。このた
めかかる問題を解決するため、次のような技術が知られ
ている。[0003] However, if fluoride ions and calcium ions coexist, calcium fluoride precipitates and vitiligo cannot be eliminated. Therefore, the following techniques are known to solve such a problem.
【０００４】フッ素イオン水溶液と、カルシウムイオン
水溶液とを別の容器に保持し、使用に際して適宜混合し
て用いる、２剤系口腔衛生用品（特開昭５２−６１２３
６号公報、特開昭５８−２１９１０７号公報）、糖リン
酸エステルによりフッ化カルシウムをコロイド状に分散
させ、再石灰化を促進する口腔用組成物（特開平３−７
２４１５号公報）。A two-part oral hygiene product (Japanese Patent Laid-Open No. 52123/1972) in which an aqueous solution of a fluoride ion and an aqueous solution of a calcium ion are held in separate containers, and are appropriately mixed for use.
No. 6, JP-A-58-219107), a composition for oral cavity in which calcium fluoride is dispersed in a colloidal form with a sugar phosphate to promote remineralization (Japanese Patent Laid-Open No. 3-7)
No. 2415).
【０００５】[0005]
【発明が解決しようとする課題】しかしながら、特開昭
５２−６１２３６号公報、特開昭５８−２１９１０７号
公報の技術では、製造工程が複雑になるうえ、使用に際
して２液を混合しなければならず、簡便性の点で問題が
あった。また特開平３−７２４１５号公報の技術では、
比較的高濃度のフッ化カルシウムをコロイド状に分散さ
せることは容易ではなく、また一般的に歯磨き剤に用い
られているアルキル硫酸エステル塩、Ｎ−アシルアミノ
酸等のアニオン界面活性剤が存在すると、上記糖リン酸
エステルの分散効果はほぼ完全に消失してしまうという
問題を有する。However, in the techniques disclosed in Japanese Patent Application Laid-Open Nos. 52-61236 and 58-219107, the manufacturing process becomes complicated and two liquids must be mixed at the time of use. However, there was a problem in terms of simplicity. In the technology disclosed in Japanese Patent Application Laid-Open No. 3-72415,
It is not easy to disperse calcium fluoride in a relatively high concentration in a colloidal form.Also, in the presence of an anionic surfactant such as an alkyl sulfate ester salt or an N-acyl amino acid generally used in dentifrices, There is a problem that the dispersing effect of the sugar phosphate ester is almost completely eliminated.
【０００６】したがって本発明は、アニオン界面活性剤
が存在する場合でも、フッ素イオンとカルシウムイオン
とからフッ化カルシウムが生成、沈澱することを抑制す
ることにより、歯の再石灰化効果を促進する口腔用組成
物を提供することを目的とする。Accordingly, the present invention provides an oral cavity which promotes the remineralization effect of teeth by suppressing the formation and precipitation of calcium fluoride from fluoride ions and calcium ions even when an anionic surfactant is present. It is intended to provide a composition for use.
【０００７】[0007]
【課題を解決するための手段】本発明者らは、上記目的
を達成すべく鋭意研究した結果、特定量のカルシウムイ
オン供給化合物と特定量のフッ素イオン供給化合物とを
特定比率で含有し、さらに甘味剤として知られている糖
アルコールを含有することにより、フッ化カルシウムの
沈澱生成を抑制し、再石灰化を促進することができるこ
とを見出し、本発明を完成した。Means for Solving the Problems The inventors of the present invention have conducted intensive studies to achieve the above object, and as a result, they have a specific amount of a calcium ion supplying compound and a specific amount of a fluorine ion supplying compound in a specific ratio, and The present inventors have found that by containing a sugar alcohol known as a sweetener, it is possible to suppress precipitation of calcium fluoride and promote remineralization, and thus completed the present invention.
【０００８】すなわち本発明は、フッ素イオン供給化合
物をフッ素換算で０．００２〜１重量％、カルシウムイ
オン供給化合物をカルシウム換算で０．００１〜０．５
重量％、及び糖アルコールを５〜９９重量％含有し、フ
ッ素イオン供給化合物の含有量（フッ素換算）に対する
カルシウムイオン供給化合物の含有量（カルシウム換
算）（重量比）が１／２以下である口腔用組成物を提供
するものである。That is, in the present invention, the fluorine ion supplying compound is 0.002 to 1% by weight in terms of fluorine, and the calcium ion supplying compound is 0.001 to 0.5% in terms of calcium.
Oral cavity containing 5 to 99% by weight of a sugar alcohol and a content (calculated as calcium) (weight ratio) of the calcium ion supplying compound to a content (calculated as fluorine) of the fluorine ion supplying compound of 1/2 or less. To provide a composition for use.
【０００９】[0009]
【発明の実施の形態】本発明に用いるフッ素イオン供給
化合物は、無機化合物、有機化合物のいずれであっても
よい。具体的には例えば、フッ化ナトリウム、フッ化カ
リウム、フッ化スズ、フッ化ケイ素酸ナトリウム、モノ
フルオロリン酸ナトリウム、フッ化アルミニウム、フッ
化銀、フッ化水素酸ヘキシルアミン、フッ化水素酸デカ
ノールアミン、フッ化水素酸オクタデセニルアミン等が
挙げられる。このうち安全性、溶解性、風味等の点から
モノフルオロリン酸ナトリウム、フッ化ナトリウムが特
に好ましい。口腔用組成物中のフッ素イオン供給化合物
の配合量は、フッ素換算で０．００２〜１重量％であ
り、０．０１〜０．２重量％であることが好ましい。
０．００２〜１重量％であることにより、口腔用組成物
の風味や物性に悪影響を与えることなく、再石灰化の効
果を向上させることができる。BEST MODE FOR CARRYING OUT THE INVENTION The fluorine ion supplying compound used in the present invention may be either an inorganic compound or an organic compound. Specifically, for example, sodium fluoride, potassium fluoride, tin fluoride, sodium fluoride silicate, sodium monofluorophosphate, aluminum fluoride, silver fluoride, hexylamine hydrofluoride, decahydrofluoride Examples thereof include nolamine and octadecenylamine hydrofluoride. Of these, sodium monofluorophosphate and sodium fluoride are particularly preferred in terms of safety, solubility, flavor and the like. The compounding amount of the fluorine ion supplying compound in the oral composition is 0.002 to 1% by weight in terms of fluorine, and preferably 0.01 to 0.2% by weight.
When the content is 0.002 to 1% by weight, the effect of remineralization can be improved without adversely affecting the flavor and physical properties of the oral composition.
【００１０】本発明に用いるカルシウムイオン供給化合
物は、無機化合物、有機化合物のいずれであってもよ
い。具体的には例えば、塩化カルシウム、臭化カルシウ
ム、硝酸カルシウム、乳酸カルシウム、グルコン酸カル
シウム、酢酸カルシウム等が挙げられる。このうち安全
性、溶解性、風味等の点から塩化カルシウム、乳酸カル
シウムが特に好ましい。口腔用組成物中のカルシウムイ
オン供給化合物の配合量は、カルシウム換算で０．００
１〜０．５重量％であり、０．００５〜０．１重量％で
あることが好ましい。０．００１〜０．５重量％である
ことにより、口腔用組成物の風味や物性に悪影響を与え
ることなく、再石灰化の効果を向上させることができ
る。The calcium ion supplying compound used in the present invention may be either an inorganic compound or an organic compound. Specific examples include calcium chloride, calcium bromide, calcium nitrate, calcium lactate, calcium gluconate, calcium acetate and the like. Among them, calcium chloride and calcium lactate are particularly preferred in terms of safety, solubility, flavor and the like. The amount of the calcium ion-supplying compound in the oral composition is 0.000 in terms of calcium.
1 to 0.5% by weight, preferably 0.005 to 0.1% by weight. When the content is 0.001 to 0.5% by weight, the effect of remineralization can be improved without adversely affecting the flavor and physical properties of the oral composition.
【００１１】またフッ素イオン供給化合物の含有量（フ
ッ素換算）に対するカルシウムイオン供給化合物の含有
量（カルシウム換算）（重量比）は、１／２以下であ
り、１／１００〜１／３であることが好ましい。１／２
以下であれば、フッ化カルシウムの生成が抑制され、再
石灰化を促進することができる。The content of calcium ion-supplying compound (calcium) (weight ratio) to the content of fluorine ion-supplying compound (fluorine) is 1/2 or less, and 1/100 to 1/3. Is preferred. 1/2
If it is below, generation of calcium fluoride is suppressed and remineralization can be promoted.
【００１２】糖アルコールは、フッ化カルシウムの生成
を抑制するとともに、再石灰化を促進する効果を有する
ものである。糖アルコールとしては例えば、ラクチトー
ル、イソマルチトール、マルトトリイトール、イソマル
トトリイトール、パニトール、イソマルトテトライトー
ル、エリスリトール、アラビトール、リビトール、キシ
リトール、ソルビトール、マンニトール、マルチトール
等が挙げられる。かかる糖アルコールはＤ体、Ｌ体のい
ずれであってもよく、またその混合物であってもよい。
このうちキシリトールは、歯垢中のムシ歯原因菌の増殖
を抑制し、歯垢のｐＨ低下を抑制する効果を有する。し
たがって本発明においては、糖アルコール中のキシリト
ールの含有量（重量比）を、１／２以上とすることが好
ましく、２／３以上とすることが特に好ましい。[0012] The sugar alcohol has an effect of suppressing the formation of calcium fluoride and promoting remineralization. Examples of the sugar alcohol include lactitol, isomaltitol, maltotriitol, isomaltotriitol, panitol, isomaltotetriitol, erythritol, arabitol, ribitol, xylitol, sorbitol, mannitol, maltitol and the like. Such sugar alcohols may be either D-form or L-form, or may be a mixture thereof.
Of these, xylitol has the effect of suppressing the growth of bacteria causing causal teeth in plaque and suppressing the decrease in pH of plaque. Therefore, in the present invention, the content (weight ratio) of xylitol in the sugar alcohol is preferably 以上 or more, particularly preferably ／ or more.
【００１３】本発明の口腔用組成物は、水を含有しない
粉末状であってもよく、また水を含有するペースト状ま
たは液状であってもよい。水を含有する場合その含有量
は特に制限はないが、１〜９０重量％であることが好ま
しい。また水を含有する場合、糖アルコールの水に対す
る含有量は、２５重量％以上であることが好ましく、３
５〜３００重量％であることが特に好ましい。糖アルコ
ールの水に対する含有量が２５重量％以上であれば、フ
ッ化カルシウムの沈澱生成を抑制し、さらに口腔用組成
物の湿潤性も向上する。また口腔用組成物に対しては、
１５重量％以上が好ましく、３０重量％以上が特に好ま
しい。The oral composition of the present invention may be in the form of a powder containing no water, or may be in the form of a paste or liquid containing water. When water is contained, its content is not particularly limited, but is preferably 1 to 90% by weight. When water is contained, the content of sugar alcohol in water is preferably 25% by weight or more, preferably 3% by weight or more.
Particularly preferred is 5 to 300% by weight. When the content of the sugar alcohol in water is 25% by weight or more, precipitation of calcium fluoride is suppressed, and the wettability of the oral composition is also improved. For oral compositions,
It is preferably at least 15% by weight, particularly preferably at least 30% by weight.
【００１４】本発明においては、口腔用組成物として一
般に用いられるアニオン界面活性剤、例えばラウリル硫
酸ナトリウム等のアルキル硫酸エステル塩、Ｎ−アシル
サルコシネート塩等のＮ−アシルアミノ酸塩等を含有し
てもよい。特にアニオン界面活性剤中のラウリル硫酸ナ
トリウムの含有量（重量比）が１／２以上である場合で
も、本発明の効果が損なわれることはない。The present invention contains an anionic surfactant generally used as an oral composition, for example, an alkyl sulfate ester salt such as sodium lauryl sulfate, an N-acyl amino acid salt such as an N-acyl sarcosinate salt and the like. You may. In particular, even when the content (weight ratio) of sodium lauryl sulfate in the anionic surfactant is 1/2 or more, the effect of the present invention is not impaired.
【００１５】なお本発明においては、本発明の効果を害
さない範囲で、口腔用組成物として一般的に用いられて
いる、無水ケイ酸、リン酸水素カルシウム、炭酸カルシ
ウム等の研磨剤、グリセリン、ポリエチレングリコール
等の湿潤剤、発泡剤、カルボキシメチルセルロースナト
リウム、カラギーナン等の粘結剤、サッカリンナトリウ
ム等の甘味剤、着色剤、パラオキシ安息香酸メチル等の
保存剤、塩化ベンゼトニウム、イソプロピルメチルフェ
ノール等の殺菌剤、消炎剤、香料等を添加することがで
きる。In the present invention, abrasives such as silicic anhydride, calcium hydrogen phosphate, calcium carbonate, glycerin, and the like, which are generally used as oral compositions, do not impair the effects of the present invention. Wetting agents such as polyethylene glycol, foaming agents, sodium carboxymethylcellulose, binders such as carrageenan, sweeteners such as sodium saccharin, coloring agents, preservatives such as methyl parahydroxybenzoate, bactericides such as benzethonium chloride, isopropylmethylphenol, etc. Anti-inflammatory agents, fragrances and the like can be added.
【００１６】本発明の口腔用組成物は、水を含有する場
合、糖アルコール、フッ素イオン供給化合物、カルシウ
ムイオン供給化合物、及びその他の添加剤を、水に添加
して撹拌または混練することにより得ることができる。
また水を含有しない場合、粉体を混合することにより、
または粉体を水に混合、溶解し、脱水、乾燥等すること
により得ることができる。本発明の口腔用組成物は、粉
歯磨剤、潤性歯磨き剤、練り歯磨き剤、液状歯磨き剤、
洗口剤等として用いることができる。When the oral composition of the present invention contains water, the composition is obtained by adding a sugar alcohol, a fluorine ion supplying compound, a calcium ion supplying compound, and other additives to water and stirring or kneading the mixture. be able to.
When not containing water, by mixing the powder,
Alternatively, it can be obtained by mixing and dissolving powder in water, dehydrating, drying and the like. The oral composition of the present invention is a dentifrice, a moisturizing dentifrice, a toothpaste, a liquid dentifrice,
It can be used as a mouthwash and the like.
【００１７】[0017]
【実施例】次に実施例を示して本発明をさらに詳細に説
明するが、本発明は以下の実施例に限定されるものでは
ない。EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.
【００１８】実施例１〜２、比較例１〜５ 表１に示す配合で、口腔用組成物（洗口液）を作成し
た。Examples 1 and 2 and Comparative Examples 1 to 5 Oral compositions (mouthwashes) were prepared with the formulations shown in Table 1.
【００１９】[0019]
【表１】 [Table 1]
【００２０】試験例１ ７本の牛歯牙を各々２分割し、表面を鏡面研磨した後、
５mm×５mmの処置面を除いて油性マニキュアで被覆して
試験に供した。ＨＥＣで増粘した乳酸緩衝液（pH４．
５）に３７℃、５日間浸漬し、表層下脱灰を形成させ
た。ここで２分割した牛歯牙切片の内一方を再石灰化処
理群、もう一方を対照群（脱灰処理のみ）として振り分
け、再石灰化処理群について、以下の再石灰化処置を行
った。即ち、５分間の洗口液処置後水洗し、３７℃の人
工唾液（pH7.0、20mM HEPES Buffer+ CaCl2 由来の1.5
mM Ca2+ ＋ K2HPO4 由来の0.9 mM PO4 3-の溶液）に約８
時間浸漬した。次いでこれを水洗し、５分間の洗口液処
置の後、再び水洗し、さらに約１６時間の再石灰化処置
を行った。この一連の処置を１０回（１０日間）行った
後、エタノールとアセトンを用いて脱水、乾燥を行っ
た。そして再石灰化処理群、対照群ともポリエステル樹
脂にて包埋した後、切断して厚さ約１００μｍの研磨切
片を作製して軟Ｘ線写真撮影を行った。次いで、再石灰
化処理群、対照群の軟Ｘ線写真を比較、観察するととも
に、画像解析を行い再石灰化率を算出した。結果を表２
に示す。また再石灰化処理群の溶解性を、透明なものを
○、濁っているものを×として判断した。結果を表２に
示す。Test Example 1 Seven bovine teeth were each divided into two, and the surfaces were mirror-polished.
Except for the treated surface of 5 mm × 5 mm, it was covered with an oily nail polish and subjected to the test. Lactic acid buffer (pH 4.
5) was immersed for 5 days at 37 ° C. to form under-surface demineralization. One of the two sections of the bovine teeth was divided into a remineralization treatment group and the other was divided into a control group (only demineralization treatment). The remineralization treatment group was subjected to the following remineralization treatment. That is, after the mouthwash treatment for 5 minutes, water washing was performed, and artificial saliva (pH 7.0, 1.5 mM derived from 20 mM HEPES Buffer + CaCl 2) at 37 ° C.
solution of 0.9 mM PO 4 3- from Ca 2+ + K 2 HPO 4 mM)
Soaked for hours. Next, this was washed with water, and after a mouthwash treatment for 5 minutes, it was again washed with water, and a remineralization treatment was further performed for about 16 hours. After performing this series of treatments 10 times (10 days), dehydration and drying were performed using ethanol and acetone. Then, both the remineralization treatment group and the control group were embedded in a polyester resin, cut, and polished sections having a thickness of about 100 μm were prepared, and soft X-ray photography was performed. Next, the soft X-ray photographs of the remineralization treatment group and the control group were compared and observed, and image analysis was performed to calculate the remineralization rate. Table 2 shows the results
Shown in In addition, the solubility of the remineralization group was judged as "good" when it was transparent, and as "poor" when it was cloudy. Table 2 shows the results.
【００２１】[0021]
【表２】 [Table 2]
【００２２】その結果、フッ化ナトリウム、乳酸カルシ
ウム、及び糖アルコールを含有する実施例１〜２は、比
較例１〜５と比べて再石灰化率が高いことが確認され
た。As a result, it was confirmed that Examples 1-2 containing sodium fluoride, calcium lactate and sugar alcohol had a higher remineralization rate than Comparative Examples 1-5.
【００２３】実施例３〜５及び比較例６、７ 表３に示す配合で、実施例４は粉歯磨剤、他の実施例及
び比較例は練歯磨剤を調製し、それぞれを上顎の前歯に
脱灰によると考えられる白斑を有する被験者５名ずつに
１ケ月間使用させた。その結果、実施例３〜５では白斑
部位の縮小傾向が認められ、特に実施例３、４ではその
効果が大きかった。一方比較例６、７は全く変化が認め
られなかった。Examples 3 to 5 and Comparative Examples 6 and 7 With the composition shown in Table 3, Example 4 prepared a toothpaste, and other Examples and Comparative Examples prepared a toothpaste. Five subjects with vitiligo, which is thought to be due to demineralization, were used for one month. As a result, in Examples 3 to 5, a reduction tendency of the vitiligo spot was recognized, and particularly in Examples 3 and 4, the effect was large. On the other hand, in Comparative Examples 6 and 7, no change was observed at all.
【００２４】[0024]
【表３】 [Table 3]
【００２５】[0025]
【発明の効果】本発明の口腔用組成物は、アニオン界面
活性剤が存在する場合でも、フッ素イオンとカルシウム
イオンとによるフッ化カルシウムの沈澱生成を抑制し、
歯の再石灰化促進効果が高い。The oral composition of the present invention suppresses the precipitation of calcium fluoride due to fluoride ions and calcium ions even when an anionic surfactant is present,
The effect of promoting remineralization of teeth is high.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 山崎 元 栃木県芳賀郡市貝町赤羽2606 花王株式会 社研究所内 (72)発明者 岡島 美由紀 栃木県芳賀郡市貝町赤羽2606 花王株式会 社研究所内 (72)発明者 上山 弘樹 栃木県芳賀郡市貝町赤羽2606 花王株式会 社研究所内 (72)発明者 前田 晃嗣 栃木県芳賀郡市貝町赤羽2606 花王株式会 社研究所内 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Moto Yamazaki 2606 Kabane-cho, Akaga-cho, Haga-gun, Tochigi Prefecture Inside Kao Co., Ltd. 72) Inventor Hiroki Ueyama 2606 Kabane-cho, Kaga-cho, Haga-gun, Tochigi Prefecture. (72) Inventor Koji Maeda 2606 Kabane-cho, Akabane-cho, Haga-gun, Tochigi Prefecture.
Claims (5)
０．００２〜１重量％、カルシウムイオン供給化合物を
カルシウム換算で０．００１〜０．５重量％、及び糖ア
ルコールを５〜９９重量％含有し、フッ素イオン供給化
合物の含有量（フッ素換算）に対するカルシウムイオン
供給化合物の含有量（カルシウム換算）（重量比）が１
／２以下である口腔用組成物。1. A fluorine ion-supplying compound containing 0.002 to 1% by weight in terms of fluorine, a calcium ion-supplying compound in an amount of 0.001 to 0.5% by weight in terms of calcium, and a sugar alcohol in an amount of 5 to 99% by weight. , The content (calcium equivalent) (weight ratio) of the calcium ion supplying compound to the content (fluorine equivalent) of the fluorine ion supplying compound is 1
/ 2 or less oral composition.
素換算）に対するカルシウムイオン供給化合物の含有量
（カルシウム換算）（重量比）が１／１００〜１／３で
ある請求項１記載の口腔用組成物。2. The oral composition according to claim 1, wherein the content (calcium equivalent) (weight ratio) of the calcium ion supplying compound to the content (fluorine equivalent) of the fluorine ion supplying compound is 1/100 to 1/3. Stuff.
キシリトールである請求項１または２記載の口腔用組成
物。3. The oral composition according to claim 1, wherein at least 1/2 (by weight) of the sugar alcohol is xylitol.
〜３のいずれか１項記載の口腔用組成物。4. The composition according to claim 1, further comprising water.
The oral composition according to any one of claims 1 to 3.
重量％以上である請求項４記載の口腔用組成物。5. The content of sugar alcohol in water is 25.
The oral composition according to claim 4, which is not less than% by weight.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP00933098A JP3354095B2 (en) | 1997-08-04 | 1998-01-21 | Oral composition |
| TW87111638A TW528602B (en) | 1997-08-04 | 1998-07-17 | Composition for use in oral cavity comprising fluorine ion providing compound, calcium ion providing compound and sugar alcohol |
| CNB981168612A CN1151772C (en) | 1997-08-04 | 1998-08-03 | Composition for use in oral cavity |
| HK99102768A HK1017610A1 (en) | 1997-08-04 | 1999-06-30 | Composition for use in oral cavity. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20901097 | 1997-08-04 | ||
| JP9-209010 | 1997-08-04 | ||
| JP00933098A JP3354095B2 (en) | 1997-08-04 | 1998-01-21 | Oral composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11106322A true JPH11106322A (en) | 1999-04-20 |
| JP3354095B2 JP3354095B2 (en) | 2002-12-09 |
Family
ID=26344031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP00933098A Expired - Fee Related JP3354095B2 (en) | 1997-08-04 | 1998-01-21 | Oral composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3354095B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006068753A1 (en) * | 2004-12-21 | 2006-06-29 | Colgate-Palmolive Company | Anti-caries oral care composition with a chelating agent |
| WO2006068750A1 (en) | 2004-12-21 | 2006-06-29 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| KR20140072055A (en) | 2011-09-28 | 2014-06-12 | 라이온 가부시키가이샤 | Oral composition |
| WO2014124950A1 (en) * | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
-
1998
- 1998-01-21 JP JP00933098A patent/JP3354095B2/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006068753A1 (en) * | 2004-12-21 | 2006-06-29 | Colgate-Palmolive Company | Anti-caries oral care composition with a chelating agent |
| WO2006068750A1 (en) | 2004-12-21 | 2006-06-29 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| US8858920B2 (en) | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| KR20140072055A (en) | 2011-09-28 | 2014-06-12 | 라이온 가부시키가이샤 | Oral composition |
| KR20180102205A (en) | 2011-09-28 | 2018-09-14 | 라이온 가부시키가이샤 | Oral composition |
| KR20180102204A (en) | 2011-09-28 | 2018-09-14 | 라이온 가부시키가이샤 | Oral composition |
| KR20180102685A (en) | 2011-09-28 | 2018-09-17 | 라이온 가부시키가이샤 | Oral composition |
| KR20180102686A (en) | 2011-09-28 | 2018-09-17 | 라이온 가부시키가이샤 | Oral composition |
| WO2014124950A1 (en) * | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
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| Publication number | Publication date |
|---|---|
| JP3354095B2 (en) | 2002-12-09 |
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