JPH10505346A - 局所用ケトコナゾール乳剤 - Google Patents
局所用ケトコナゾール乳剤Info
- Publication number
- JPH10505346A JPH10505346A JP8508476A JP50847696A JPH10505346A JP H10505346 A JPH10505346 A JP H10505346A JP 8508476 A JP8508476 A JP 8508476A JP 50847696 A JP50847696 A JP 50847696A JP H10505346 A JPH10505346 A JP H10505346A
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- ketoconazole
- acid
- emulsion according
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.乳剤が酸化防止剤としての亜硫酸ナトリウムを含まないことを特徴とする、 ケトコナゾールを含み且つ6〜8の範囲内のpHを有する乳剤。 2.50重量%〜80重量%の水を含む請求の範囲第1項に記載の水中油型乳剤 。 3.クリーム調剤の形態をとる請求の範囲第2項に記載の乳剤。 4.乳剤ゲルの形態をとり、脂肪性材料の濃度が1重量%〜10重量%の範囲で ある請求の範囲第2項に記載の乳剤。 5.イミダゾリジニルウレア、セトリミド、ナトリウムEDTA及びジアゾリジ ニルウレアの群から選ばれる2種又はそれ以上の殺微生物性防腐剤を含む請求の 範囲第1項に記載の乳剤。 6.乳化剤、緩衝系、湿潤剤、酸又は塩基、安定化剤、殺微生物性防腐剤又は増 粘剤をさらに含む請求の範囲第1項に記載の乳剤。 7.組成物の合計重量に基づく重量により: (a)0.5〜5%のケトコナゾール; (b)組成物のpHを6〜8の範囲内に維持するための緩衝剤、酸又は塩基; (c)組成物の分解を防ぐのに十分な皮膚科学的に許容され得る殺微生物性防 腐剤; (d)0.5〜40%の皮膚科学的に許容され得る油;ならびに (e)100%までの水 を含む請求の範囲第1項に記載の乳剤。 8.クリームの形態をとり且つ組成物の合計重量に基づく重量により: (a)0.5%〜5%のケトコナゾール; (b)pHを6〜8の範囲内に維持するための緩衝剤、酸又は塩基; (c)0.1%〜0.5%のジアゾリジニルウレア及び0.1%〜0.5%の ナトリウムEDTA; (d)0.5%〜5%のイソプロピルミリステート; (e)5%〜10%の1−オクタデカノール及び1%〜5%の1−ヘキサデカ ノール; (f)0.5%〜5%のソルビタンモノステアレート及び0.5%〜5%のポ リソルベート 60; (g)5%〜10%のプロピレングリコール; (h)0.05%〜0.2%のポリソルベート 80;ならびに (i)100%までの水 を含む請求の範囲第7項に記載の乳剤。 9.乳剤ゲルの形態をとり且つ組成物の合計重量に基づく重量により: (a)0.5〜5%のケトコナゾール; (b)pHを6〜8の範囲内に維持するための緩衝剤、酸又は塩基; (c)0.1%〜0.5%のイミダゾリジニルウレア、0.1%〜0.5%の セトリミド及び0.1%〜0.5%のナトリウムEDTA; (d)1%〜10%の分別されたココナツ油; (e)0.1%〜2%のカーボマー及び0.1%〜0.5%のポリエチレンオ キシド; (f)5%〜10%のプロピレングリコール; (g)0.1%〜0.5%のポリソルベート 80;ならびに (h)100%までの水 を含む請求の範囲第7項に記載の乳剤。 10.治療的有効量のケトコナゾールを皮膚科学的に許容され得る担体と緊密に 混合することを特徴とする請求の範囲第1〜9項のいずれかに記載の乳剤の調製 法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94202505 | 1994-09-01 | ||
DE94202505.7 | 1994-09-01 | ||
PCT/EP1995/003366 WO1996006613A1 (en) | 1994-09-01 | 1995-08-25 | Topical ketoconazole emulsions |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10505346A true JPH10505346A (ja) | 1998-05-26 |
JP3959110B2 JP3959110B2 (ja) | 2007-08-15 |
Family
ID=8217156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50847696A Expired - Lifetime JP3959110B2 (ja) | 1994-09-01 | 1995-08-25 | 局所用ケトコナゾール乳剤 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5854246A (ja) |
EP (1) | EP0778771B1 (ja) |
JP (1) | JP3959110B2 (ja) |
KR (1) | KR100381701B1 (ja) |
CN (1) | CN1098074C (ja) |
AT (1) | ATE291917T1 (ja) |
AU (1) | AU698065B2 (ja) |
CA (1) | CA2198240C (ja) |
DE (1) | DE69534120T2 (ja) |
DK (1) | DK0778771T3 (ja) |
ES (1) | ES2240977T3 (ja) |
IL (1) | IL115105A (ja) |
MX (1) | MX9701397A (ja) |
MY (1) | MY115980A (ja) |
PT (1) | PT778771E (ja) |
SI (1) | SI0778771T1 (ja) |
TW (1) | TW460296B (ja) |
WO (1) | WO1996006613A1 (ja) |
ZA (1) | ZA957329B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531526A (ja) * | 1998-12-04 | 2002-09-24 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 無水状態の局所的皮膚調製剤 |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9604610D0 (sv) * | 1996-12-16 | 1996-12-16 | Noviscens Ab | Medical composition |
WO1998051273A1 (en) * | 1997-05-12 | 1998-11-19 | Sage Pharmaceuticals, Inc. | Topical spray for burn treatment and anti-infection |
DK0981330T3 (da) * | 1997-05-14 | 2002-12-02 | Galen Chemicals Ltd | Topiske præparater |
AUPO983897A0 (en) | 1997-10-17 | 1997-11-06 | Soltec Research Pty Ltd | Topical antifungal composition |
US5980904A (en) * | 1998-11-18 | 1999-11-09 | Amway Corporation | Skin whitening composition containing bearberry extract and a reducing agent |
MXPA01010676A (es) * | 1999-04-23 | 2003-08-20 | Leo Pharm Prod Ltd | Composicion farmaceutica de vitamina d o un analogo de vitamina d y al menos un corticoesteroide. |
US20040077540A1 (en) * | 2002-06-28 | 2004-04-22 | Nastech Pharmaceutical Company Inc. | Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US7700076B2 (en) * | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
EP2410976A1 (en) * | 2009-03-25 | 2012-02-01 | Sulur Subramaniam Vanangamudi | A medicinal cream for diaper rash and a process to make it |
CA2795611C (en) * | 2009-04-13 | 2016-09-20 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer and a process to make it |
BG66048B1 (bg) * | 2009-04-21 | 2010-12-30 | Емил ЯМАЛИЕВ | Състав и метод за получаване на козметичен противопърхутен гел |
US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
CN102018667B (zh) * | 2010-10-29 | 2012-08-08 | 杭州雷布科技有限公司 | 一种咪唑类抗真菌皮肤擦拭剂及其制备方法 |
EA032840B8 (ru) | 2011-06-22 | 2020-06-18 | Вайоми Терапеутикс Лимитед | Пролекарства на основе конъюгатов противогрибковых агентов и их применение |
US8530409B1 (en) * | 2012-06-12 | 2013-09-10 | Dipexium Pharmaceuticals LLC | Stable pexiganan formulation |
MX2015016675A (es) | 2013-06-04 | 2016-07-15 | Vyome Biosciences Pvt Ltd | Particulas recubiertas y composiciones que comprenden las mismas. |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
CN110876756A (zh) * | 2019-12-17 | 2020-03-13 | 罗香英 | 用于治疗灰指甲的药膏 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US456935A (en) * | 1891-08-04 | Axle-cutter | ||
US4144346A (en) * | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
US4942162A (en) * | 1982-03-31 | 1990-07-17 | University Of Tennessee Research Corporation | Topical treatment of seborrheic dermatitis with ketoconazole |
US4569935A (en) * | 1983-03-17 | 1986-02-11 | University Of Tennessee Research Corp. | Topical treatment of psoriasis with imidazole antibiotics |
JPH0774145B2 (ja) * | 1986-12-15 | 1995-08-09 | 株式会社資生堂 | 結晶性薬物含有乳化組成物 |
US4976953A (en) * | 1987-03-06 | 1990-12-11 | The Procter & Gamble Company | Skin conditioning/cleansing compositions containing propoxylated glycerol derivatives |
US5002974A (en) * | 1988-04-04 | 1991-03-26 | Warner-Lambert Co. | Anesthetic/skin moisturizing composition and method of preparing same |
GB8910069D0 (en) * | 1989-05-03 | 1989-06-21 | Janssen Pharmaceutica Nv | Method of topically treating acne vulgaris |
GB9014221D0 (en) * | 1990-06-26 | 1990-08-15 | Janssen Pharmaceutica Nv | Method of treating alopecia |
US5215839A (en) * | 1991-12-23 | 1993-06-01 | Xerox Corporation | Method and system for reducing surface reflections from an electrophotographic imaging member |
US5456851A (en) * | 1994-04-07 | 1995-10-10 | Johnson & Johnson Consumer Products, Inc. | Ketoconazole shampoo containing butylated hydroxytoluene or butylated hydroxyanisole |
-
1995
- 1995-07-07 TW TW084107005A patent/TW460296B/zh not_active IP Right Cessation
- 1995-08-25 CA CA002198240A patent/CA2198240C/en not_active Expired - Lifetime
- 1995-08-25 JP JP50847696A patent/JP3959110B2/ja not_active Expired - Lifetime
- 1995-08-25 KR KR1019970701169A patent/KR100381701B1/ko not_active IP Right Cessation
- 1995-08-25 MX MX9701397A patent/MX9701397A/es unknown
- 1995-08-25 AT AT95931931T patent/ATE291917T1/de active
- 1995-08-25 ES ES95931931T patent/ES2240977T3/es not_active Expired - Lifetime
- 1995-08-25 AU AU35183/95A patent/AU698065B2/en not_active Expired
- 1995-08-25 US US08/793,359 patent/US5854246A/en not_active Expired - Lifetime
- 1995-08-25 SI SI9530718T patent/SI0778771T1/xx unknown
- 1995-08-25 DE DE69534120T patent/DE69534120T2/de not_active Expired - Lifetime
- 1995-08-25 DK DK95931931T patent/DK0778771T3/da active
- 1995-08-25 PT PT95931931T patent/PT778771E/pt unknown
- 1995-08-25 CN CN95194847A patent/CN1098074C/zh not_active Expired - Lifetime
- 1995-08-25 WO PCT/EP1995/003366 patent/WO1996006613A1/en active IP Right Grant
- 1995-08-25 EP EP95931931A patent/EP0778771B1/en not_active Expired - Lifetime
- 1995-08-30 IL IL11510595A patent/IL115105A/xx not_active IP Right Cessation
- 1995-08-31 ZA ZA957329A patent/ZA957329B/xx unknown
- 1995-09-01 MY MYPI95002592A patent/MY115980A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002531526A (ja) * | 1998-12-04 | 2002-09-24 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 無水状態の局所的皮膚調製剤 |
Also Published As
Publication number | Publication date |
---|---|
AU3518395A (en) | 1996-03-22 |
CA2198240A1 (en) | 1996-03-07 |
IL115105A0 (en) | 1995-12-08 |
CA2198240C (en) | 2007-04-10 |
ATE291917T1 (de) | 2005-04-15 |
MX9701397A (es) | 1997-05-31 |
WO1996006613A1 (en) | 1996-03-07 |
CN1156407A (zh) | 1997-08-06 |
KR100381701B1 (ko) | 2003-09-26 |
DE69534120T2 (de) | 2006-01-26 |
TW460296B (en) | 2001-10-21 |
US5854246A (en) | 1998-12-29 |
AU698065B2 (en) | 1998-10-22 |
PT778771E (pt) | 2005-08-31 |
IL115105A (en) | 1999-12-22 |
CN1098074C (zh) | 2003-01-08 |
ES2240977T3 (es) | 2005-10-16 |
SI0778771T1 (en) | 2005-10-31 |
EP0778771B1 (en) | 2005-03-30 |
ZA957329B (en) | 1997-02-28 |
JP3959110B2 (ja) | 2007-08-15 |
MY115980A (en) | 2003-10-31 |
DK0778771T3 (da) | 2005-07-25 |
DE69534120D1 (de) | 2005-05-04 |
EP0778771A1 (en) | 1997-06-18 |
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