JPH10297679A - Packaging body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent alteration of the contents of respective chambers of a container during preservation thereof and also prevent alteration of the contents in the other chambers resulting from water or reactive gas extracted from the chamber, by forming partition seals of a package at the positions forming isolation seals of the container. SOLUTION: A container 2 is divided into a plurality of chambers 4, 5 by an isolation seal 3 in which mutual inner walls of a resin container 2 are stuck with a peel-seal which is peelable on using it. And two sheets 6, 7 having a moisture and gas-barrier property are superposed at the outside of the container 2 and the mutual ends are sealed. And the container 2 is put and sealed at the position where the isolation seal 3 of the container 2 is formed, to form a partitioned seal part 10 and form packaging parts 8, 9 partitioned to correspond to the chambers 4, 5. In this way, even when the water in the liquid- container 5 in the container 2 has leaked to the partitioned packaging part 9 of the package 1, the water does not penetrate into the partitioned packaging part 8 and hence, the contents of the chamber 4 are prevented from altering.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a package of containers for storing medicines to be used separately when stored and mixed together when used, and more particularly to a resin container having a flexible wall. The interior of the container is formed of a plurality of chambers by an isolation seal portion in which the inner walls of the container are adhered to each other, and at least a part of the isolation seal portion is formed of a peel seal that can be peeled off from the outside of the container during use. TECHNICAL FIELD The present invention relates to a package for packaging a container obtained. A container for storing a dry substance that cannot be stored for a long time due to the presence of moisture, a gas-generating agent that generates ammonia, volatile amines, or the like, or a readily permeating agent that easily deteriorates due to the presence of oxygen, such as pharmaceuticals. The present invention relates to a package in the above.

[0002]

2. Description of the Related Art Usually, a container for storing and storing two or more reactive agents is divided into a plurality of chambers. Then, containers are provided in which the respective medicines are housed in separate chambers. In some cases, the plurality of chambers that divide the inside of the container are formed by an isolated seal portion in which the inner walls of the container are bonded. The isolation seal portion is formed of a peel seal that can be peeled off from the outside of the container by an operation, and the reactive agents can be easily mixed with each other by peeling the isolation seal portion during use. Such a container having a plurality of chambers is used for a two-part adhesive such as an epoxy adhesive resin or a two-part hair dye for cosmetics. Furthermore, it is also used in medical containers and the like for infusions and the like in which amino acids and sugars are separated. Further, since these are resin containers, those formed of container walls having gas permeability and moisture permeability are also used. For this reason,
Such a container is packaged in a package having moisture or gas barrier properties.

[0003]

However, the package for such a container having a plurality of chambers has the following problems. First, since the container is made of resin, moisture or a reactive gas component from the stored material permeates the container wall and comes out of the package. The water that has flowed out of the package again enters the other storage chamber of the container filled with the dried product or the like.
For this reason, the dried product absorbs moisture, and cannot be stored for a long time. Similarly, the generated gas component may also once exit between the outside of the container and the inside of the package, and may again enter another storage chamber of the container and react with other contents. Secondly, there is a case where a readily permeating agent easily deteriorated due to the presence of oxygen is contained in the container. For this reason, there is a possibility that oxygen outside the container may permeate through the container wall and act on the drug to cause deterioration.
For this reason, the package is made of a gas barrier material, and an oxygen scavenger is disposed in the package. However, a large amount of oxygen is required to remove oxygen from the entire inside of the package with an oxygen absorber, and a long-term oxygen removal function may not be maintained. Thirdly, if the package has moisture and gas barrier properties, the moisture or reactive gas generated from the container wall will accumulate moisture etc. with time in the package, and this storage will be the content of other chambers. Seriously affects things. Therefore, the present invention provides a package in which the contents in each room of the container are not deteriorated during storage, and the contents in other rooms are not deteriorated by moisture or reactive gas generated from the room. Is to do.

[0004]

SUMMARY OF THE INVENTION The present invention is a resin container having a flexible wall, wherein the inside of the container is formed of a plurality of chambers by an isolated seal portion in which the inner walls of the container are adhered to each other. In a packaging body for packaging a container in which at least a part of the isolation seal portion is formed by a peel seal that can be peeled off from the outside of the container when used, two sheets having at least one of moisture and gas barrier properties The package is formed by sealing the edges of the sheet to form a wrapping portion, and forming a separate seal portion sandwiching the container at a position where an isolation seal portion of the container is formed. The above object has been achieved by providing a package characterized in that parts are divided corresponding to a plurality of chambers.

[0005] A resin container having a plurality of chambers has a flexible wall. The flexible wall may be any as long as the volume in the container is easily changed by bending. Further, it is desirable that the container wall has such transparency that the contents can be confirmed. This is because it is necessary to confirm the state of the medicine in the container. The resin container is formed from an inflation film, a tube, a sheet, and a film, or is formed by extrusion, injection, or blow molding. The material of the resin container is a general-purpose resin such as polyolefin resin, vinyl chloride, vinylidene chloride resin, polyester resin, polyvinyl alcohol resin, polyacrylonitrile resin, polyacrylic acid resin, and polyamide resin. Further, the resin container may be formed in a single layer or a multilayer. The innermost layer that comes into contact with the drug in the container does not affect the drug,
In addition, it is desirable that the resin layer does not generate eluted substances. As such a resin, a polyolefin-based resin is desirable, and examples thereof include low-, middle-, and high-density lower-grade olefin resins such as polyethylene and polypropylene.

[0006] The resin container is formed by separating the inside with a plurality of chambers with an isolation seal portion in which the inner walls thereof are adhered to each other, and at least a part of the isolation seal portion is a peel seal which can be peeled off when used from the outside of the container. It is formed by. If the isolation seal portion is formed by a peel seal as described above, different medicines can be accommodated in each chamber, and even medicines that react with each other can be stored for a long period of time. When the medicines are mixed and used, the chambers communicate with each other and can be easily mixed only by peeling off the isolation seal portion without opening the container. For this reason, it is particularly desirable to form such an isolated seal portion when aseptic mixing is required, such as in a medical infusion. Examples of the adhesive seal between the inner walls include a liquid-tight seal via an adhesive or a heat seal. As an adhesive, a ketone solvent, an ester solvent,
There is a hermetic seal via a solvent adhesive such as an ether solvent, a hydrocarbon solvent, or a halogenated hydrocarbon solvent, or a resin adhesive such as a modified olefin or a hot melt. In addition, as the heat welding seal, heat sealing, adhesion by external heating such as impulse seal, or ultrasonic bonding,
Adhesion by internal heating such as high-frequency bonding can be given. These are then formed as peelable seals. Normally, the peel seal portion is also called a weak seal portion, which presses the chamber or the container from the outside and grips and pulls the seal portion or the container outer wall which can be peeled off when the inside is pressurized to a certain level. It is a seal or the like that can be peeled off when it is pressed. The peel strength of the peel seal portion is such that the indoor pressure is 0.01 to 1.0 kgf / c.
m ² , in particular, a peeling strength at a pressure increase of 0.05 to 0.5 kgf / cm ² is desirable. If the strength is lower than the above range, the safety for maintaining an isolated state at the time of production, transportation, storage and the like is lacking. If the strength exceeds the above range, there is a possibility that the communication operation between the rooms cannot be easily performed at the time of use.

The package is composed of two stacked sheets having at least one of moisture and gas barrier properties. The sheet includes a film. Further, the sheets may be inflation-molded, blow-molded, or extruded cylindrical sheets that overlap one another as long as they are overlapped.
Specific examples of the moisture barrier sheet include a metal layer made of aluminum or the like, which has almost no or no gas permeation, polyvinylidene chloride, polytetrafluoroethylene, polytrifluoroethylene, rubber hydrochloride, polyethylene,
Resin layer with high water vapor barrier properties such as polypropylene, aluminum, silicon, magnesium, titanium, silver,
It has an earth metal or metal such as gold, or a vapor-deposited layer of an oxide thereof. The moisture permeability of the moisture barrier layer in the package is 15 g / m ² · day (temperature: 40 ° C.,
90% RH, per 30 μm) or less, especially 5 g / m ²
Day or less, and preferably 1 g / m ² · day or less. As a specific gas barrier sheet, the sheet wall has little or no gas permeation, such as a metal layer such as aluminum, polyvinylidene chloride,
Resin layer with high gas barrier property such as polyester, nylon, ethylene-vinyl alcohol copolymer, fluororesin, etc., or earth metal or metal such as aluminum, silicon, magnesium, titanium, silver, gold, or oxidation thereof It has a vapor deposition layer of an object. The oxygen permeation amount of the gas barrier layer in the package is 40 cc.20 μ / m ^2.
day · atm (temperature: 20 ° C) or less, especially 30 cc
20 µ / m ² · day · atm or less, preferably 5 cc · 20 µ / m ² · day · atm or less, and more preferably 1 cc
It is desirably not more than cc · 20 μ / m ² · day · atm. The carbon dioxide permeation amount of the gas barrier layer in the package is 200 cc · 20 μ / m ² · day · atm.
(Temperature: 25 ° C.) or less, especially 100 cc · 20 μ / m
²・ day ・ atm or less, preferably 10cc ・ 2
0 μ / m ² · day · atm or less, further 1 cc · 20
It is desirably not more than μ / m ² · day · atm.
Further, as the sheet having a moisture barrier property and a gas barrier property, the metal layer, the polyvinylidene chloride layer,
The one having both the moisture and gas barrier resin layers and the like.

The container / packaging portion of the package is formed by sealing the edges of the sheet to form an edge seal portion. The edge seal portion may be a peelable seal portion or a non-peelable seal portion. Examples of the adhesive seal between the sheets include a liquid-tight seal via an adhesive or a heat seal. As the adhesive, a solvent adhesive such as a ketone solvent, an ester solvent, an ether solvent, a hydrocarbon solvent, a halogenated hydrocarbon solvent, or a resin adhesive such as a modified olefin or a hot melt is used. There are hermetic seals and the like. In addition, heat sealing, heat sealing,
Adhesion by external heating such as an impulse seal or adhesion by internal heating such as ultrasonic bonding or high-frequency bonding can be given. Further, in the package according to the present invention, a division seal portion is formed by sealing the container at a position where the isolation seal portion of the container is formed, and the packaging portion is divided corresponding to a plurality of chambers. Become. Due to the presence of the divisional seal portion, even if the moisture or the generated gas component of the contents permeates through the chamber wall of the container and comes out into the package, the moisture remains in the divisional packaging portion of the other room of the container containing the dried product and the like. Less likely to shift to Therefore, the dried product can be safely stored for a long time. Similarly, the reactive gas component is less likely to react with the contents of the other chamber of the container.

According to a second aspect of the present invention, there is provided the package according to the first aspect, wherein the sealing portion at the edge and the divided sealing portion are formed of a peelable peel seal. . First, if the edge seal section and the section seal section are peelable peel seals, the package can be easily opened. That is, to peel off the end seal portion,
By peeling off the end seal portion, the sheets of the package can be separated from each other and the package can be opened. Secondly, the moisture or evolved gas comes out of the package in the partitioned packaging section during storage. In such a case, if the package is a moisture or gas barrier wall, moisture or generated gas is stored in the divided packaging section. When moisture is stored, molds or the like may be generated in the packaging portion, and the packaging portion may expand due to generated gas, which may adversely affect the package and the container. However, in the package according to the present invention, the stored moisture and the like can be gradually released to the outside from the peel seal portion at the peelable end. This is because, unlike the non-peelable seal portion, the peel seal portion usually has incomplete adhesion between the seal portions and thus has a property of gradually transmitting moisture or generated gas.

According to a third aspect of the present invention, there is provided the package according to the first aspect, wherein at least a part of the seal portion at the edge is formed of a peelable peel seal, and the sectional seal portion is non-peelable. It is characterized by being formed with a peel seal. If the end seal portion is formed of a peel seal portion, the above-described moisture or generated gas is gradually released from the seal portion and does not accumulate in the package. On the other hand, since the section seal section is a non-peelable seal section, it is difficult for moisture or generated gas to permeate through the end section seal section. For this reason, the water or gas generated from the container wall is
It does not affect the contents of the other compartments of the container and does not accumulate in the package.

According to a fourth aspect of the present invention, there is provided the package according to any one of the first to third aspects, wherein a dried product is contained in one chamber of the container and a liquid agent is contained in the other chamber. And a desiccant is disposed in a divided wrapping section surrounding the chamber in which the dried product is stored, and the sheet is formed of a sheet having a moisture barrier property. The dried product is a powder or a solid, and when it absorbs moisture, it changes quality in a short period of time. A typical example of such a dried product is a lyophilized agent. Further, the liquid agent may be distilled water that is merely a solution of a dried product, or may be an aqueous solution in which various drugs, nutrients, and electrolytes are dissolved. In a resin container containing such contents, as described above, moisture is stored in one compartment of the package from the room containing the liquid medicine during storage. It does not move into the compartmental wrapping section that wraps the chamber, but gradually passes through the end seal section to the outside world. For this reason, moisture does not invade into the divisional wrapping part which wraps the dry matter room, and as a result,
Dry matter is sufficiently preserved. In addition, by placing the desiccant in the divisional packaging section that wraps the storage room for the dried product,
Since the desiccant removes moisture and the like that enter from the outside through the end seal, further preservation of the dried product is ensured. The desiccant itself is a substance having a strong hygroscopic property, and may be a chemical desiccant or a physical desiccant. Preferred drying agents include porous structures such as silica gel, activated alumina, calcium chloride, and molecular sieves.

According to a fifth aspect of the present invention, there is provided the package according to the fourth aspect, wherein the other chamber in the container contains a readily permeating chemical solution, and contains the easily permeating liquid solution. An oxygen scavenger is disposed in the divisional wrapping section surrounding the chamber, and the sheet is formed of a sheet having a gas barrier property and a gas barrier property. In the other room of the package according to the present invention, a readily permeating chemical liquid that is easily degraded by the presence of oxygen can be stored. The easily oxygen-deteriorating chemical solution may be a liquid agent, a suspension agent, or the like, and is a drug in which oxygen is present and which undergoes alteration or the like by heating at 100 ° C. or more such as high-pressure steam sterilization. Such drugs include:
For example, tryptophan, amino acids such as methionine,
Examples include vitamins, physiologically active substances such as physostigmine, ergotamine and adrenaline, chemical agents such as hydralazine and chlorpromazine, antibiotics such as chloramphenicol and macrolite antibiotics, and easily oxidizable inorganic salts. In this case, in order to enhance the preservability of the chemical solution, an oxygen scavenger is disposed in the divided packaging portion. Examples of the oxygen scavenger include organic compounds mainly composed of ascorbic acid and catechol-based compounds, and powdery compounds composed of metals such as iron and metal halides. In particular,
It is commercially available from "Ageless" (Mitsubishi Gas Chemical Co., Ltd.) and other manufacturers. Examples of the oxygen scavenger include those that only absorb oxygen and those that absorb oxygen to generate carbon dioxide gas. In this way, the oxygen absorber and the desiccant are placed in separate compartments,
Although the oxygen scavenger does not function in a dry state, it functions well because of the action of moisture from the liquid agent and the like, and does not remove the inside of the divided packaging section provided with the desiccant, so it is less than removing the entire package. The use of an amount of oxygen scavenger is sufficient.

According to a sixth aspect of the present invention, there is provided the package according to any one of the first to third aspects, wherein at least one chamber in the container has a gas-generating agent permeating a resin wall. And the sheet is formed of a gas barrier sheet. The gas generating agent generates a gas that reacts with the agent in the other chamber during storage, and the generated gas generally permeates the resin layer gradually. Examples of the gas generating agent include an amine-based solution used for a hair dye and the like, and other aqueous ammonia. Since the gas of the gas generating agent has a property of passing through the gap of the peelable peel seal extremely easily, it is desirable that the end seal of the package be a peelable seal as described above. That is, as described above, the gas is stored in one compartment of the package from the room containing the gas generating agent during storage, but such gas does not move into the compartment of the other room. , And exits to the outside world through the end seal. For this reason, the reactive gas does not enter into the compartmentalized wrapping portion surrounding the other chamber, and the contents are sufficiently preserved.

According to a seventh aspect of the present invention, in the package according to any one of the first to sixth aspects, the isolation seal portion is formed by directly heat sealing the inner walls of the container. The inner layer of the container wall is formed of a blend of a plurality of resins having different melting start temperatures. The above-described isolation seal portion may be formed by using an adhesive or the like as described above. However, directly heat sealing the inner walls to each other greatly improves the workability in manufacturing, and the adhesive or the like is applied to the contents. This is preferable in that it does not adversely affect it. For this reason, it becomes a very effective seal part for containers such as infusion solutions. It is preferable that the innermost layer of the container wall of the isolation seal portion is formed of a plurality of resin blends having different melting start temperatures. When forming a peel seal between inner layers or forming a non-peelable seal by heat welding,
In order to surely form them in different states, the inner layer is desirably a blend of different resins. In particular, it is desirable that the different resins be made of resin blends having different hot-melting onset temperatures or Picad softening points and little compatibility. By having such a blended material layer, it is possible to easily set the sealing temperature conditions for complete hermetic seal bonding with the same inner layer, but also to easily set the sealing temperature conditions for peel seal bonding. Further, the relationship between the seal strength required for peel seal adhesion, that is, the easy peelability due to external force during use, and the seal strength that does not cause peeling during storage can be strictly set. That is, a resin having different compatibility is melt-mixed in the inner layer, and this is formed into a sheet to form a surface which is microscopically separated into portions having different thermal adhesiveness. Then, by deciding the thermal fusibility of the microscopic part between the surfaces of the sheet at an arbitrary temperature, the strength of the seal strength is accurately given,
The above effects are easily achieved.

According to an eighth aspect of the present invention, there is provided the package according to the first to sixth aspects, wherein the sealing portion at the edge and the divisional sealing portion are formed by heat sealing. The inner layer is formed of a blend of a plurality of resins having different melting start temperatures. As in the case of the container, it is desirable from the viewpoint of the manufacture of the seal portion and the quality of the seal portion that the sheet of the package is heat-sealed and sealed to form the end seal portion and the divided seal portion.

A package according to a ninth aspect of the present invention is the package according to the first aspect, wherein the sheet is a moisture and gas barrier sheet having a metal layer. If the sheet has a metal layer, for example, an aluminum layer, the package will be permeable to little or no moisture and gas. In particular, even in a heated state, moisture or gas does not easily pass unlike the barrier resin layer. Therefore, it is suitable for a medical container package in which the container and the package are subjected to high-pressure steam sterilization. In addition, if it is a package of a medical container, it must be able to visually confirm the inside of the container in a part. Therefore, claim 9
The above-described package may be characterized in that the metal layer can be peeled off at least a part of the sheet, and the wall surface to be peeled has a moisture or gas barrier resin layer.

[0017]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of a package according to the present invention will be described below in detail with reference to the accompanying drawings. FIG. 1 is a front view showing a package of a medical container according to the first embodiment. FIG.
FIG. 2 is a front view of the medical container in the package of the first embodiment. FIG. 3 is an enlarged sectional view of the sheet of the package of the first embodiment. FIG. 4 is a sectional view of an end seal portion of a sheet of the package of the first embodiment. FIG. 5 is a front view showing a package of the hair dye container of the second embodiment. FIG. 6 (A) and (B)
FIG. 7 is a cross-sectional view of a section seal portion and an end seal portion of the package of the second embodiment.

The package 1 according to the first embodiment is a resin container 2 having a flexible wall, and the inside of the container 2 is divided into a plurality of chambers 4 and 5 by an isolation seal portion 3 in which the inner walls of the container 2 are adhered to each other. And the container 2 is formed by a peel seal in which the isolation seal portion 3 can be peeled off from the outside of the container 2 during use. In such a package 1, the package 1 is composed of two superposed sheets 6 and 7 having a moisture and gas barrier property, and the packaging portions 8 and 9 are formed by sealing the edges of the sheets. Is formed at a position where the container is formed, and a sealing section 10 is formed with the container sandwiched therebetween so that the packaging sections 8 and 9 are divided corresponding to the plurality of chambers 4 and 5. In the package 1, the edge sealing portion 1A and the section sealing portion 10 are formed of peelable peel seals.
In the package 1, one of the chambers 4 in the container 2 contains an antibiotic 11 which is a lyophilized product, and the other room 5 contains a readily permeating drug solution 12 and a chamber containing the antibiotic 11. A desiccant 13 is provided in the section wrapping portion 8 that wraps the wrapper 4. In the package 1, an oxygen absorber 14 is provided in a divisional wrapping section 9 that wraps the chamber 5 containing the easily permeating liquid 12. In the package 1, the isolation seal portion 3 is formed by directly heat sealing the inner walls of the container 2, and the inner layer of the container 2 wall is formed of a blend of a plurality of resins having different melting start temperatures. In the package 1, the seal portions 1A and the divisional seal portions 10 at the edges of the sheets 6, 7 are formed by heat sealing, and the inner layer between the sheets 6, 7 is a blend of a plurality of resins having different melting start temperatures. It is formed with. In the package 1, the sheets 6 and 7 correspond to the metal layer 2.
It is a moisture and gas barrier sheet having 5, 29. The metal layer 25 can be peeled off from the sheet 6, and the surface 6 </ b> A of the peeled wall has a moisture and gas barrier resin layer 22.

The package 1 according to the present embodiment will be described in more detail. The container stored in the package 1 is a medical container 2. The medical container 2 is formed by cutting a blown film having a folding diameter of 70 mm into a length of 120 mm.
The medical container 2 is formed such that the cut ends 2A and 2B of the overlapping films are heat-sealed and sealed. The film is formed of an inner layer and an outer layer, and the inner layer is composed of two types of blends having different thermal melting onset temperatures. That is, the inner layer has a thickness of 50 μm,
It is a blend of linear low-density polyethylene and polypropylene, and the outer layer is a linear low-density polyethylene having a thickness of 200 μm. The medical container 2 has two chambers 4 in the container,
The medical container 2 has a dry substance storage chamber 4 and a liquid medicine storage chamber 5 formed therein. The dried substance storage chamber 4 stores a freeze-dried antibiotic 11 which cannot be stored for a long time if it contains moisture and the like, and the solution storage chamber 5 is a solution of the antibiotic 11 and is easily dissolved by the presence of oxygen. An oxygen-degrading chemical solution 12 that deteriorates is stored. As shown in FIG. 2, the isolation seal portions 3, 3 are formed in a peel seal portion which is peeled off by an operation on the outside. At the time of use, the desiccant storage chamber 4 and the liquid storage chamber 5 are aseptically communicated with each other, so that the medical container 2 becomes one chamber. When the cut edges 2A and 2B are completely heat-sealed, the outlet 15 is attached to the medical container 2, and the outlet 15 is a cylindrical polyethylene molded product. A rubber stopper is attached to the outlet 15, and the outlet 15 is liquid-tightly sealed with the rubber stopper.

As shown in FIG. 1, the package 1 of the medical container 2 is composed of two sheets 6, 7;
, The upper, lower, left, and right edges are hermetically sealed by heat welding, and an edge seal portion 1A is formed in the package 1. In addition, the package 1 is formed with a divisional seal portion 10 by a heat-sealing seal with the isolation seal portions 3 of the medical container 2 interposed therebetween, and the interior of the package 1 is divided into two divisional package portions 8 and 9. Have been.
The edge seal 1A and the section seal 10 are formed of peelable peel seals. Therefore, the desiccant storage chamber 4 of the medical container 2 is air-tightly covered by the divisional wrapping section 8 of the package 1, and the liquid medicine storage chamber 5 is airtightly covered by the divisional wrapping section 9 of the package 1. A desiccant 13 is provided in the sorting and wrapping section 8, and an oxygen absorber 14 is provided in the sorting and wrapping section 9. The desiccant 14 is composed of molecular sieves,
Is a carbon dioxide-generating oxygen scavenger containing bicarbonate.

As shown in FIG. 3, the front sheet 6 has an innermost layer 21
Is a blend of linear low density polyethylene and propylene having a thickness of 100 μm, and the first intermediate layer 22 has a thickness of 15 μm.
μm polyvinylidene chloride layer, the second intermediate layer 23 and the third intermediate layer 24 are stretched nylon layers, the fourth intermediate layer 25 is a 9 μm thick aluminum layer, and the outer layer 26 is a 12 μm thick polyethylene terephthalate layer. Consists of Then, a release surface A is formed between the second intermediate layer 23 and the third intermediate layer 24, and the front sheet 6 borders the release surface A,
It is divided into a peeled wall 6A and a peeled wall 6B. Peeling wall 6
B has a non-transparent fourth intermediate layer 25 (aluminum layer), and the stripped wall 6A has a gas barrier first intermediate layer 22 (vinylidene chloride layer). Stripped wall 6
Since A has the first intermediate layer 22, its oxygen gas permeability is 1 cc / m ² · day · atm or less, and it is transparent enough to confirm the contents. On the other hand, in the back sheet 7, the innermost layer 27 is a blended layer of linear low-density polyethylene and polypropylene with a thickness of 100 μm, the first intermediate layer 28 is a stretched nylon with a thickness of 15 μm, and the second intermediate layer 29 is a 9 μm thick. The outer layer 30 is made of a 12 μm thick polyethylene terephthalate layer. Therefore, the innermost layers 21, 27 of both sheets 6, 7
Is a heat-sealing seal layer, and as shown in FIG. 4, the end sealing portion 1A of the package 1 is a peelable heat-sealing seal portion.

Next, assembly, sterilization and manufacture of the package 1 of the medical container 2 according to the first embodiment will be described. First,
To form the medical container 2, the cut end 2A of the blown film cut into a predetermined size is completely heat-sealed and sealed. Fully heat-sealed seals have a seal temperature of 160
Perform at or above ° C. At the time of such sealing, an outlet 15 is attached. Next, two isolation seal portions 3 are formed on a predetermined body portion of the film. The formation of the isolation seal portion 3 is performed at a heat seal temperature of 125 ° C. to 140 ° C. Then, the isolation seal portion 3 is a peel seal portion having a strength that does not peel off immediately before use. Next, the heat-resistant antibiotic 11 is aseptically filled from the open end 2B of the film, and the open end 2B is completely heat-sealed and sealed. This allows the antibiotic 11 to be liquid-tightly inserted into the dry matter storage chamber 4 of the medical container 2. Next, the easily permeating oxygen chemical 12 is filled from the outlet 15, and the outlet 15 is sealed with a rubber stopper. Thus, the easily oxygen-degradable chemical liquid 12 can be stored in the liquid storage chamber 5 of the medical container 2 in a liquid-tight manner.

Next, the front sheet 6 and the back sheet 7 of the package 1 cut into a rectangular shape are overlapped with the medical container 2 interposed therebetween. Division seal part 1 along isolation seal parts 3 of container 2
0 is formed. Next, the desiccant 13 is inserted into the sheets 6 and 7 on the dry matter storage chamber 4 side, and the oxygen absorber 14 is inserted into the sheets 6 and 7 on the liquid material storage chamber 5 side. After the insertion, the inner layers around the front sheet 6 and the back sheet 7 are heat-sealed and sealed to form the end sealing portion 1A of the package 1. Division seal part 10
The formation of the end seal portion 1A is performed at a temperature of 140 ° C. or lower to form a peel seal portion. Next, the medical container 2 and the package 1 are subjected to high-pressure steam sterilization. Sterilization is performed in an autoclave at a temperature of 110 ° C. After cooling, the peeling wall 6B is peeled from the front sheet 6 of the package 1, and the antibiotic 11 and the chemical solution 12 in the medical container 2 can be confirmed to be a product.

In the package 1 configured as described above,
Due to the presence of the sorting seal portion 10, even when moisture comes out of the liquid material storage chamber 5 of the container 2 to the sorting packaging portion 9 of the package 1, the moisture is prevented from migrating to the sorting packaging portion 8 of the packaging body 1. You. For this reason, the divided packaging section 8 is maintained in an atmosphere having no moisture by dehumidifying the desiccant 13, and the antibiotics 11 in the dry matter storage chamber 4 of the container 2 are less likely to deteriorate during storage. The package 1 of the present embodiment is a peel seal in which the edge seal portion 1A and the section seal portion 10 are peelable.
When performing the opening, the sheet 6 and the sheet 7 can be separated from each other by peeling off each other. For this reason, opening of the package 1 becomes extremely easy. In addition, since the package 1 is usually composed of the moisture barrier sheets 6 and 7, moisture is stored in the liquid container 5 in the sorting package 9. When the stored water increases, the inside of the sorting and wrapping section 9 becomes a saturated steam state, which has an adverse effect such as causing propagation of mold and the like. But,
Since the edge seal portion 1A of the package 1 of this embodiment is a peel seal portion, no moisture is stored in the divided packaging portion 9.
That is, the stored water can be gradually released from the peel seal at the peelable end 1A to the outside. Unlike the non-peelable seal part, the peel seal part is not easy to transmit moisture or generated gas because the adhesion between the seal parts is not perfect, which may exceed the moisture permeating from the container 2 wall. .

Further, since the oxygen absorber 14 is disposed only in the liquid agent storage chamber 5 in the medical container 2, a long-term oxygen desorption operation can be expected without requiring a large amount of oxygen absorber. . The desiccant 13 is placed in the divisional wrapping section 8 that wraps the dry matter storage chamber 4.
Is disposed, the desiccant 13 removes moisture and the like that intrude from the outside via the end seal, so that further preservability is ensured. Further, as described above, the oxygen scavenger 14 and the desiccant 1
3 is disposed in the separate packaging portions 8 and 9 so that the oxygen scavenger 14 does not function in a dry state.
It works satisfactorily due to the action of moisture and the like. Further, since the sheets 6 and 7 have the metal layers 22 and 29, the package 1 does not transmit oxygen and moisture at all during the above-mentioned high-pressure steam sterilization, thereby preventing the intrusion of oxygen and moisture into the package 1. can do. After the high-pressure steam sterilization and cooling, the state of the antibiotic 11 and the easily permeating oxygen solution 12 in the container 2 can be confirmed by peeling off the peeling wall 6B of the front sheet 6 of the package 1. Therefore, the deterioration of the medicine 11 and the chemical solution 12 during the high-pressure steam sterilization in the medical container 2 can be completely prevented.

Next, a package according to a second embodiment of the present invention will be described with reference to FIGS. FIG. 5 is a front view showing a package of the hair dye container of the second embodiment. FIG.
(A) And (B) is sectional drawing of the division | segmentation seal part and end seal part of the package of 2nd Example. The package 31 according to the second embodiment is a resin container 32 having a flexible wall, and the inside of the container 32 is formed of a plurality of chambers 34 and 35 by an isolation seal portion 33 in which the inner walls of the container 32 are adhered to each other. As in the first embodiment, the isolation seal portion 33 is packaged with a container 32 formed of a peel seal that can be peeled off from the outside of the container 32 during use. In addition, such a package 31
The two stacked sheets 3 having gas barrier properties
6 and 37, a section in which the packaging sheets 38 and 39 are formed by sealing the edges of the sheets 36 and 37, and the container 32 is sealed at a position where the isolation sealing part 33 of the container 32 is formed. Forming the seal portion 40 to form the packaging portions 38, 3
The same applies to the point that 9 is divided corresponding to the plurality of chambers 34 and 35. The difference of the package 31 according to the second embodiment is that the seal 31A at the edge is formed by a peelable peel seal, but the section seal 40 is formed by a non-peelable seal. In the package 31, one chamber 34 in the container 32 contains a main agent 41 of a hair dye containing ammonia water and paraphenylenediamine, and the other chamber 35 contains a hair dye containing a hydrogen peroxide solution. During storage, a part of the ammonia of the main agent 41 permeates through the wall of the container 32 and comes out into the sorting and packaging portion 38. Therefore, the container is the container 32 containing the hair dye. In the package 31, the seal portions 31 A and the section seal portions 40 at the edges of the sheets 36 and 37 are formed by heat welding and sealing, and the inner layer between the sheets 36 and 37 is a blend of a plurality of resins having different melting start temperatures. It is formed with. In the package 31, the sheets 36 and 37 are gas barrier sheets including a vinylidene chloride layer. That is, the sheets 36 and 37 have transparency, the innermost layer is a blend layer capable of heat welding linear low-density polyethylene and polypropylene, and the intermediate layer has a vinylidene chloride layer.

In the package 31 having such a configuration,
The following functions and effects are obtained in addition to the effects similar to those of the first embodiment. Ammonia gas is generated from the chamber 34 of the resin container 32, and the ammonia gas passes through the chamber wall 34 and is stored in the divided packaging section 38 of the package 31. As shown in FIG. 6A, the stored ammonia gas in the sorting and wrapping section 38 is
An attempt is made to pass through the adhesive surface of the sorting seal portion 40 and move into the sorting packaging portion 39. However, since the divided seal portion 40 is formed by the non-peelable seal portion, the ammonia gas is
As shown in (B), priority is given to release to the outside through the adhesive surface of the peel seal portion of the edge seal portion 31A of the package 31. Therefore, expansion in the sorting and wrapping portion 38 is suppressed, and ammonia enters the sorting and wrapping portion 39 to cause the container 32 to expand.
There is no possibility of reacting with the auxiliary agent 42 in the chamber 35.

[0028]

According to the package according to the present invention, the package consists of two superposed sheets having at least one of a barrier property against moisture and gas, and the edges of the sheets are sealed to form a package portion. In addition, since a separate seal portion sealing the container is formed at a position where the isolation seal portion of the container is formed, and the packaging portion is divided corresponding to a plurality of chambers, The contents in each room are not deteriorated, and the contents in other rooms are not deteriorated by moisture or reactive gas generated from the room.

[Brief description of the drawings]

FIG. 1 is a front view showing a package of a medical container according to a first embodiment.

FIG. 2 is a front view of the medical container in the package of the first embodiment.

FIG. 3 is an enlarged sectional view of a sheet of the package of the first embodiment.

FIG. 4 is a cross-sectional view of an end sealing portion of a sheet of the package of the first embodiment.

FIG. 5 is a front view showing a package of the hair dye container of the second embodiment.

FIGS. 6A and 6B are cross-sectional views of a section seal portion and an end seal portion of the package of the second embodiment.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Package 1A Edge seal part 2 Medical container 3 Isolation seal part 4 Dried substance storage room 5 Liquid material storage chamber 6, 7 Sheets 8, 9 Division packaging part 10 Division seal part 11 Antibiotic 12 Oxygen easily permeating chemical liquid 13 Drying Agent 14 Oxygen scavenger

Claims (10)

[Claims] 1. A resin container having a flexible wall, wherein an inside of the container is formed by a plurality of chambers with an isolation seal portion in which inner walls of the container are adhered to each other, and at least a part of the isolation seal portion is formed. A packaging body for packaging a container formed of a peel seal that can be peeled off from the outside of the container during use, comprising two stacked sheets having at least one of moisture and gas barrier properties, A wrapping portion is formed by sealing the edges, and a divided seal portion sealing the container is formed at a position where the isolation seal portion of the container is formed, and the wrapping portion corresponds to a plurality of chambers. A package characterized in that it is divided into two parts. 2. The package according to claim 1, wherein the seal portion and the partition seal portion at the edge are formed of a peelable peel seal. 3. The package according to claim 1, wherein at least a part of the seal portion at the edge is formed of a peelable peel seal, and the divided seal portion is formed of a non-peelable seal. . 4. A desiccant is placed in one of the compartments in the container for containing a dried product and the other compartment for containing a liquid agent, and a compartmentalized packaging section surrounding the compartment containing the dried product is provided. The package according to any one of claims 1 to 3, wherein the sheet is formed of a sheet having a moisture barrier property. 5. A deoxidizing agent is disposed in a separate wrapping portion surrounding the chamber accommodating the easily permeable oxygen-containing chemical solution in the other chamber in the container. The package according to claim 4, wherein the sheet is formed of a sheet having a moisture barrier property and a gas barrier property. 6. A gas generating agent permeating a resin wall is accommodated in at least one chamber in the container, and the sheet is formed of a gas barrier sheet. A package according to any one of the above. 7. The isolation seal portion is formed by directly heat sealing the inner walls of the container, and the inner layer of the container wall is formed of a blend of a plurality of resins having different melting start temperatures. The package according to any one of claims 1 to 6. 8. An edge seal section and a section seal section of the sheet are formed by heat sealing, and an inner layer of the sheets is formed of a blend of a plurality of resins having different melting start temperatures. The package according to any one of claims 1 to 6. 9. The package according to claim 1, wherein said sheet is a moisture and gas barrier sheet having a metal layer. 10. The package according to claim 11, wherein said metal layer is peelable on at least one of said sheets, and said wall surface to be peeled has a moisture or gas barrier resin layer.