JPH10274699A - Radiation irradiation device for blood bag - Google Patents

Abstract

PROBLEM TO BE SOLVED: To unify the dose distribution in the thickness direction of a blood bag by irradiating a plurality of blood bags with radiation and reversing the upper and lower surface on a turntable and irradiating when the irradiation reaches a specific radiation dose. SOLUTION: Blood bags 3 are put on a turn table 2 maintaining mutual position relation, X-ray radiation dose of one time is written in a dose meter 6, a controller 9 is activated to start X-ray irradiation and the turntable 2 is rotated. By this, the blood bags 3 are irradiated with X-ray evenly from the front side. When the X-ray radiation dose reached that written in the dose meter 6, the dose meter 6 outputs a dose reaching signal to the controller 9. The controller 9 terminates rotation and irradiation and elevates the turn table 2 to reverse the up side down. After reversing, it is returned to the original irradiation position to evenly irradiate X-ray from the back side of the blood bags 3 same as from the front side. Thus, by radiating X-ray from the front and the back, unification of dose distribution in the thickness direction is attained.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a radiation irradiating apparatus for a blood bag capable of uniformly irradiating a plurality of blood bags with radiation.

[0002]

2. Description of the Related Art In recent years, GVHD (Graft Vers.
Us Host Disease (graft-versus-host disease) is a problem. In order to prevent this, X-rays and γ-rays at appropriate doses are applied to blood before blood transfusion (including blood products separated for each blood component (red blood cells, platelets, etc.) and sealed in a blood storage bag; the same applies in the present specification). It is said that it is effective to inactivate lymphocytes and the like in blood by irradiating radiation such as an electron beam, for example, X-rays of 15 to 50 gray (1500 to 5000 rad),
Currently spreading.

[0003] By the way, when irradiating such blood, the blood is usually put into a bag for storing the blood (this is called a blood storage bag for blood transfusion, including a blood product storage bag, the same in the present specification). It is performed in a state using a radiation irradiation device for blood bags. The radiation to be applied is generally X
Lines are used.

In a conventional X-ray irradiator of this type, an X-ray tube device is arranged at an upper portion in an apparatus housing, and a blood bag (a blood storage bag for transfusion-transfused blood) is provided at the center of the X-ray irradiation field. The same is applied in this specification.), And a table for placing X-rays thereon is arranged. In this case, it is known that the distribution of the X-ray dose emitted from the X-ray tube device is not uniform in the irradiation field, and in order to improve the distribution, a turntable is used for the table, and the turntable that rotates on a plane is used. Put a lot of blood bags on top of
It was configured to emit X-rays.

[0005]

However, the prior art described above has a problem that the dose distribution in the thickness direction of the blood bag cannot be made uniform. Therefore, a device was considered in which one X-ray tube device was arranged on each of the upper and lower sides of the turntable and X-rays were emitted from the front and back surfaces of the blood bag. However, this requires two X-ray tube devices. There was a problem that the device became expensive. Further, the X-ray tube device is arranged on one of the left and right sides, and after irradiating the X-ray from one side of the blood bag, the side of the blood bag is inverted, and then the X-ray is applied to the blood bag again. There are also devices that irradiate the blood bag with X-rays from both sides (front and back) by irradiating the blood bag. According to this, it is possible to achieve both a uniform dose distribution in the thickness direction of the blood bag and a reduction in the cost of the apparatus, but one blood bag is processed by one X-ray irradiation, and the processing capacity is low. There was a problem.

SUMMARY OF THE INVENTION An object of the present invention is to provide a radiation irradiation apparatus for a blood bag which can achieve both a uniform dose distribution in the thickness direction of the blood bag and a low price of the apparatus and which does not reduce the processing capacity. is there.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a turntable capable of placing a plurality of blood bags side by side on an upper surface and capable of reversing the upper and lower surfaces while maintaining the mutual positional relationship between the plurality of blood bags; A radiation source for irradiating the plurality of blood bags on the mounting surface from above or below the blood bag mounting surface of the turntable, and emitting radiation from the radiation source while rotating the turntable. Irradiate a plurality of blood bags on the turntable, and when reaching a predetermined radiation dose according to the set total radiation dose to the plurality of blood bags, invert the upper and lower surfaces of the turntable, again said Control means for emitting radiation from the radiation source while rotating a turntable and irradiating a plurality of blood bags on the turntable with radiation. Kick is achieved by.

According to this, a plurality of blood bags are placed on the turntable and irradiated with X-rays. That is, 1
Since a plurality of blood bags are processed by a single X-ray irradiation, the processing capacity is not reduced. The radiation source irradiates the radiation from above or below the blood bag mounting surface of the turntable, and only one radiation source is required. The turntable can be turned upside down and the blood bag can be irradiated from the front and back surfaces. It is possible to achieve both uniform dose distribution in the bag thickness direction and low cost of the apparatus. The turntable can be turned upside down while maintaining the mutual positional relationship of the plurality of blood bags on the upper surface, so that the blood bag does not drop, displace, or be folded when the top and bottom surfaces are turned over.

[0009]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a block diagram showing one embodiment of a radiation irradiation device for a blood bag according to the present invention.
In FIG. 1, 1 is a radiation source, here an X-ray tube device, 2 is a turntable on which a plurality of blood bags 3 can be placed on the upper surface, and 4 is a high voltage for applying a high voltage to the X-ray tube device 1. The generator 5 is disposed below the turntable 2 and transmits the X-rays (blood bags 3.
6 is a dosimeter that receives a signal from the probe 5 and displays an X-ray dose, and 7 is an X-ray shield such as lead that houses the turntable 2 and the probe 5. A protection box made of material, 8 is a cooler for cooling the X-ray tube device 1, and 9 is a controller for controlling the X-ray tube device 1, the turntable 2, the cooler 8, and the like.

The X-ray tube apparatus 1 is provided above the turntable 2, and the X-ray tube apparatus 1 is
X-rays can be applied to the plurality of blood bags 3 on the mounting surface from above the blood bag mounting surface.

The turntable 2 is capable of basic rotation as a turntable (normal rotation around an axis) and has a plurality of blood bags 3 mounted on the upper surface. The upper and lower surfaces can be inverted while maintaining the mutual positional relationship.

That is, as shown in FIGS. 2 and 3, the turntable 2 has a bottomed cylindrical case 10 for mounting and storing a plurality of, for example, four blood bags 3,. A cover plate 11 for holding the fixed blood bag 3 sandwiched by a case bottom plate 10a, a rotation drive unit 12 for rotating the case 10 around a normal axis, and a reversal drive unit 13 for reversing the upper and lower surfaces of the case 10. And the vertical drive unit 14.

In this case, a plurality of annular grooves 10b are formed in the inner peripheral surface of the case 10 in a line in the axial direction (vertical direction in the figure), and the cover plate 11 is inserted into any of the annular grooves 10b. The spacing dimension formed by the case bottom plate 10a and the lid plate 11 can be selected depending on whether or not to do so. Therefore, blood bag 3
The blood bag 3 can always be securely fixed in the case 10 even when the thickness of the blood bag 3 changes depending on the amount of blood in the blood bag and the type (mainly the size) of the blood bag 3. , No displacement, folding or dropping of the blood bags 3 occurs. Case 1
The bottom plate 10a and the cover plate 11 are made of a material such as carbon fiber which has little X-ray absorption and a certain strength or more, and has a large number of holes so that the mutual positions of the blood bags 3 inside can be visually recognized. .., 11a.

In FIG. 3, reference numeral 10d denotes a cover plate guide groove formed on the inner peripheral surface of the case 10 so as to intersect with the plurality of annular grooves 10b, 11b denotes a knob formed on the cover plate 11,
c is a flange. The cover plate 11 is inserted into the annular groove 10b by holding the knob 11b and rotating the flange portion 11c by aligning the flange portion 11c with the desired annular groove 10b via the cover plate guiding groove 10d of the case 10, and The blood bags 3 are positioned and fixed.

The outer peripheral side of the case 10 has a roller 15
And the outer periphery of the case and the rotation drive unit 12
A belt 16 is hung between each other, and the case 10
Is rotatable around the axis by the drive of the rotation drive unit 12.

Further, both sides of the turntable mounting board 17 on which the case 10 and the rotary drive unit 12 are disposed are rotatably supported by rollers 18, and are further linked to a reversal drive unit 13 via a sprocket 19 and a chain 20. And substrate 1
7. In other words, the case 10 (turntable 2) can be turned upside down by driving the reversing drive unit 13.

When the turntable mounting board 17 is turned upside down, the up-and-down mechanism section 14 moves up simultaneously with the board turning operation so that the board 17 does not collide with the turntable mounting surface 21, and moves down after the turning is completed. It operates to return the turntable 2 to the original X-ray irradiation position.

The controller 9 basically emits X-rays from the X-ray tube apparatus 1 while rotating the turntable 2 to irradiate the blood bags 3 on the turntable 2 with X-rays. When a predetermined X-ray irradiation amount corresponding to the set total X-ray irradiation amount (total required X-ray irradiation amount) to the blood bags 3 is reached, the upper and lower surfaces of the turntable 2 are inverted, and the turntable 2 is rotated again. While emitting X-rays from the X-ray tube apparatus 1, the blood bags 3 on the turntable 2 are irradiated with X-rays. Here, the control of the raising and lowering operation of the vertical mechanism unit 14 is also performed.

The controller 9 inputs the amount of blood in the blood bag 3, the type of the blood bag 3, etc. (mainly, the size and the type of contents), and the X-ray irradiation amount for one time corresponding thereto. , And also has a function of writing to the dosimeter 6. 1
Although it is efficient that the dose of X-rays for each batch is １ ／ of the total dose of X-rays, a ratio different from １ ／ before and after inversion of the turntable may be set.
In this case, the ratio may be automatically selected by inputting the amount of blood in the blood bag 3, the type of the blood bag 3, and the like.

Next, the operation of the apparatus of the present invention will be described with reference to FIG. Now, turntable 2 has blood bag 3
Are placed in a state where mutual positional relationship is maintained. Further, it is assumed that the dosimeter 6 has written therein a single X-ray irradiation dose (here, 1/2 of the total X-ray dose applied to the blood bag 3).

In this state, when an X-ray irradiation button (not shown) is pressed at time t1, the controller 9 is activated, and
The irradiation of the X-ray starts and the turntable 2 (Case 1)
0) is rotated. Thereby, the blood bags 3 are rotated on the upper surface of the turntable 2 while maintaining the mutual positional relationship, and are uniformly irradiated with X-rays from the surface side.
During this time, the dosimeter 6 measures the X-ray irradiation dose via the probe 5.

At time t2, when the measured value of the X-ray irradiation dose reaches the one-time X-ray irradiation dose written in the dosimeter 6, the dosimeter 6 outputs a dose reaching signal to the controller 9. (In the example of FIG. 4, the dose reaching signal falls).
Thereby, the controller 9 controls the rotation of the turntable 2 and the X
The line irradiation is stopped and the turntable 2 is raised.

At time t3, when the lift of the turntable 2 is completed, the upper and lower surfaces of the turntable 2 are inverted. At this time, the blood bags 3 are in a state of maintaining the mutual positional relationship, and the blood bags 3 do not fall from the turntable 2, do not shift in position, and do not overlap. Time t
In 4, when the upside down of the turntable 2 is completed, the turntable 2 is lowered to return to the original X-ray irradiation position.

At time t5, when the turntable 2 descends and returns to the original X-ray irradiation position, X-ray irradiation is started again and the turntable 2 (case 10) is rotated. Thus, while maintaining the mutual positional relationship, the blood bags 3 are rotated on the upper surface of the turntable 2 and are evenly irradiated with X-rays from the back surface thereof. During this time, the dosimeter 6 measures the X-ray irradiation dose via the probe 5.

At time t6, when the measured value of the X-ray irradiation dose reaches the one-time X-ray irradiation dose written in the dosimeter 6, the dosimeter 6 outputs a dose reaching signal to the controller 9. (In the example of FIG. 4, the dose reaching signal falls).
Thereby, the controller 9 controls the rotation of the turntable 2 and the X
The X-ray irradiation is stopped, and the X-ray irradiation process is completed.

As described above, the difference in the irradiation X-ray dose in the thickness direction of the blood bag 3 as well as the difference in the irradiation X-ray dose depending on the mounting position of each blood bag 3 on the turntable 2 (on the plane) is small. And each blood bag 3 ... and blood bag 3
The dose distribution in each part is made uniform.

[0027]

As described above, according to the present invention, X-rays are radiated only from above the blood bag mounting surface of the turntable, so that only one radiation source is required and the turntable can be turned upside down. Since the blood bag can be irradiated with X-rays from the front and back surfaces, it is possible to achieve both uniform dose distribution in the thickness direction of the blood bag and low cost of the apparatus. A plurality of blood bags are placed on the turntable and irradiated with X-rays. That is, since a plurality of blood bags are processed by one X-ray irradiation, there is an effect that the processing capacity is not reduced.

[Brief description of the drawings]

FIG. 1 is a block diagram showing an embodiment of the device of the present invention.

FIG. 2 is a perspective view showing an example of a turntable portion of the apparatus of the present invention.

FIG. 3 is an enlarged exploded perspective view of a case and a lid constituting the turntable.

FIG. 4 is a time chart for explaining the operation of the device of the present invention.

[Explanation of symbols]

1 X-ray tube device (radiation source) 2 turntable 3
... blood bag, 4 ... high voltage generator, 5 ... probe, 6
... dosimeter, 7 ... protective box, 8 ... cooler, 9 ... controller (control means), 10 ... case, 11 ... lid plate, 12 ... rotary drive unit, 13 ... reversal drive unit, 14 ... vertical mechanism unit, 15,
18 roller, 16 belt, 17 turntable mounting board, 19 sprocket, 20 chain, 21 turntable mounting surface.

Claims (1)

[Claims] 1. A turntable capable of mounting a plurality of blood bags side by side on an upper surface, and capable of reversing the upper and lower surfaces while maintaining the mutual positional relationship of the plurality of blood bags, and mounting a blood bag on the turntable. A radiation source that irradiates the plurality of blood bags on the mounting surface from above or below the surface, and a plurality of blood bags on the turntable that emits radiation from the radiation source while rotating the turntable. When a predetermined radiation dose corresponding to the set total radiation dose to the plurality of blood bags is reached, the upper and lower surfaces of the turntable are reversed, and the radiation is rotated while rotating the turntable again. Control means for emitting radiation from a source and irradiating a plurality of blood bags on the turntable with radiation. Irradiation apparatus for the bag.