JPH10194966A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an emulsion composition useful as a cosmetic or medicinal composition for skin, lotion by including each specific copolymer and polysiloxane so as to afford an oil-in-water emulsion with high reserve stability. SOLUTION: This emulsion composition contains (A) pref. 0.01-10wt.% of an acrylic/methacrylic alkyl ester copolymer and (B) pref. 0.01-10wt.% of a methacryl-modified methylpolysiloxane, and pref. Furthermore, (C) decamethylcyclopentanesiloxane, and, in addition, optionally, a hydrocarbon such as vaseline.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an emulsified composition useful for cosmetics and a pharmaceutical composition for external use on the skin.

[0002]

2. Description of the Related Art In an oil-in-water emulsion, a continuous phase is an aqueous phase,
It is an emulsified form in which the oil phase is dispersed in it, and the continuous phase is the aqueous phase. It is a dosage form widely used in cosmetics and cosmetics. However, since the continuous phase is an aqueous phase, it is easily re-emulsified by sweat, etc., and has a detergency on the skin. There was a problem. For this reason, during emulsification, measures such as lowering the HLB of the surfactant have been devised,
It was not enough to show the effect. Attempts have also been made to improve the usability and the storage properties of water-in-oil emulsion compositions with a high internal phase.However, oil-in-water emulsions have the advantage of oil-in-water emulsions, The development of improved oil-in-water emulsions has been awaited.

On the other hand, an acylacrylic acid / alkyl methacrylate copolymer is known as a thickener having an emulsifying power, and a methacryl-modified methylpolysiloxane is known as a feel improving agent for makeup cosmetics. It was not known at all that using these in combination or further combining them would provide an oil-in-water emulsion having good storage properties.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of such circumstances, and it is an object of the present invention to provide an oil-in-water emulsion having good storage properties.

[0005]

Means for Solving the Problems In view of such circumstances, as a result of intensive studies, it has been found that by combining an acylacrylic acid / alkyl methacrylate copolymer with methacryl-modified methylpolysiloxane, oil-in-water having good storage properties is obtained. They found that an emulsion was obtained, and completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Acylacrylic acid / alkyl methacrylate copolymer used in the present invention The acylacrylic acid / alkyl methacrylate copolymer used in the present invention is commercially available as a thickener having an emulsifying power and is used in cosmetics and the like. Have been. Many of these are commercially available and readily available. For example, Pemulen TR-
1, Pemulen TR-2, Carbopol 1382 (all manufactured by Goodrich Co., Ltd.) and the like, and all of them can be used as the acrylic acid / alkyl methacrylate copolymer of the present invention. In the present invention, the acrylic acid / alkyl methacrylate copolymer can be used with a free carboxylic acid, but is preferably used as a salt. Any salt can be used without particular limitation as long as it is physiologically acceptable. Examples thereof include alkali metal salts such as sodium and potassium, alkaline earth metals such as magnesium and calcium, triethylamine and triethylamine. Preferred examples include organic amine salts such as ethanolamine, ammonium salts, and basic amino acid salts such as lysine and arginine. Of these, use as a potassium salt is particularly preferred. In the present invention, these may be used alone or in combination of two or more. In the emulsion composition of the present invention, a preferable content of the acrylic acid / alkyl methacrylate copolymer is 0.01% with respect to the whole emulsion composition.
10 to 10% by weight, more preferably 0.05 to 7% by weight, even more preferably 0.1 to 5% by weight.

(2) Methacryl-modified methylpolysiloxane used in the present invention The methacryl-modified methylpolysiloxane used in the present invention is commercially available as a cosmetic raw material as a touch improver for improving powder thickness, and is used in cosmetics. Have been.
As a commercially available product, silicone KP-545 (manufactured by Shin-Etsu Chemical Co., Ltd.), which is a 30% decamethylcyclopentasiloxane solution, is preferably used from the viewpoint of operation. The preferred content of the methacryl-modified methylpolysiloxane in the present invention is 0.01 to 10% by weight, more preferably 0.05 to 8% by weight, and more preferably 0.1 to 10% by weight based on the emulsified composition.
-5% by weight is more preferred.

(3) Emulsion composition of the present invention The emulsion composition of the present invention is characterized by containing the above-mentioned acrylic acid / alkyl methacrylate copolymer and methacryl-modified methylpolysiloxane. As the use of the emulsified composition of the present invention, creams and emulsions for protecting the skin, under makeup, foundation, cosmetics such as UV protection, External skin pharmaceutical compositions such as antifungal agents and anti-inflammatory agents can be exemplified. Since the emulsified composition of the present invention is also excellent in the dispersibility of the powder, the characteristics can be particularly exhibited in a system in which the powder such as an under-makeup, a foundation and an ultraviolet protective agent is blended. In addition, a pharmaceutical composition for external use on the skin is useful for reducing the number of times of recoating and for suppressing the occurrence of phototoxicity caused by a drug when used together with powder. The emulsion composition of the present invention can contain optional components used in such a preparation other than the above essential components as long as the effects of the present invention are not impaired. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, Fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Thickeners, preservatives, ultraviolet absorbers, antioxidants, pigments, powders and the like. It goes without saying that pharmaceuticals can also contain medicinal ingredients. The emulsion composition of the present invention can be produced by treating these components according to a conventional method. The emulsified composition of the present invention thus obtained is excellent in feeling in use and excellent in storage.

[0009]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Example 1 Production Example A cream was prepared according to the following formulation. That is, A and B were each heated and dissolved at 80 ° C., and B was gradually added to A for emulsification, followed by stirring and cooling to obtain a refreshing cream having a feeling of use. I Behenyl alcohol 2 parts by weight Solid paraffin 5 parts by weight Methacryl-modified methylpolysiloxane 2 parts by weight Decamethylcyclopentasiloxane 16 parts by weight butyl paraben 0.1 part by weight b 1,3-butanediol 5 parts by weight glycerin 3 parts by weight Xanthan gum 0. 3 parts by weight Methyl paraben 0.1 parts by weight Pemulen TR-2 0.5 parts by weight Potassium hydroxide 0.5 parts by weight Water 65.5 parts by weight

<Example 2> Comparative test The cream of Example 1 and Pemulen T of the cream of Example 1
For Comparative Example 1 in which R-2 was substituted with sodium stearate and Comparative Example 2 in which the methacryl-modified methylpolysiloxane of Example 1 was substituted with decamethylcyclopentasiloxane, the retention of the decorative film was tested. That is, four 2 cm × 4 cm parts are provided on the inner part of the upper arm, 0.02 ml of the sample is applied to each part, and after allowing to stand for 10 minutes, the flowing water is allowed to flow for two minutes. Drop a drop of water here and let the state of the drop be ++: close to a sphere,
+: The swell was clearly recognized, ±: Slightly swelled,-: The swell was observed and judged on the basis of unclear criterion. The number of cases was five. Table 1 shows the results. This shows that the emulsified composition of the present invention maintains an excellent decorative film.

[0012]

[Table 1]

Example 3 Production Example Under make-up was prepared according to the following formulation.
That is, A and B were each heated and melted at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, and the mixture was stirred and cooled to obtain a refreshed under-use make-up. I-Behenyl alcohol 2 parts by weight Methacryl-modified methyl polysiloxane 1 part by weight Decamethylcyclopentasiloxane 14 parts by weight Butyl paraben 0.1 part by weight Diglycerin 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight 0.1 parts by weight methyl paraben Pemlen TR-1 0.3 parts by weight Potassium hydroxide 0.3 parts by weight Water 72 parts by weight C Hydrogen methyl siloxane baked titanium mica 1 part by weight Hydrogen methyl siloxane baked mica 0.5 part by weight Hydrogen methyl siloxane baked titanium dioxide 0.4 parts by weight Hydrogenmethylsiloxane baking Bengala 0.1 parts by weight

<Example 4> Comparative test Under-make-up Pemlen TR- of Example 3 and under-make-up of Example 3
For Comparative Example 3 in which 1 was replaced with sodium stearate and Comparative Example 4 in which the methacryl-modified methylpolysiloxane of Example 3 was replaced with decamethylcyclopentasiloxane, the retention of the decorative film was tested. That is, four 2 cm × 4 cm sections are provided on the inner side of the upper arm, and a specimen is placed at 0.
02 ml, apply a foundation on top,
After leaving still for 10 minutes, it was lightly rubbed with a finger three times in running water. Press the tissue to wipe off the moisture and visually check the amount of the remaining foundation. ++: Almost remaining, +:
Observation and judgment were made on the basis of clearly remaining, ±: slightly remaining,-: not remaining. The number of cases was five. Table 2 shows the results. This shows that the emulsified composition of the present invention maintains an excellent decorative film. In addition, it can be seen that the under-make-up, which is the emulsion composition of the present invention, is excellent in the effect of improving the holding of the foundation.

[0015]

[Table 2]

Example 5 Production Example An ultraviolet protective agent was prepared according to the following formulation. That is, A and B were each heated and melted at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, followed by stirring and cooling to obtain a refreshing UV protective agent having a feeling of use. I Behenyl alcohol 2 parts by weight Methacryl-modified methylpolysiloxane 1 part by weight Decamethylcyclopentasiloxane 14 parts by weight 2-ethylhexyl paramethoxycinnamate 5 parts by weight 4-tert-butyl-4-methoxybenzoylmethane 2 parts by weight butyl paraben 0 0.1 parts by weight Polypropylene glycol 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methyl paraben 0.1 parts by weight Pemulene TR-2 0.5 parts by weight Potassium hydroxide 0.5 parts by weight Water 64 parts by weight Aluminum 2.5 parts by weight of stearate-treated titanium dioxide

Example 6 Comparative Test Comparative Example 5 in which the ultraviolet protective agent of Example 5 and pemulene TR-2 of the ultraviolet protective agent of Example 5 were replaced with sodium stearate, and the methacryl-modified methylpolysiloxane of Example 5 Was replaced with decamethylcyclopentasiloxane, and the storage property of the decorative film was tested. That is, four 2 cm × 4 cm sites were provided inside the upper arm, and 0.02 ml of the sample was applied to each site, allowed to stand for 10 minutes, and then rubbed lightly with fingers three times in running water. Press the tissue to wipe off the moisture and visually check the amount of remaining UV protection.
+: Almost remaining, +: Clearly remaining, ±: Slightly remaining,-: Not observed and judged based on the following criteria. The number of cases was five. Table 3 shows the results. This shows that the emulsified composition of the present invention maintains an excellent decorative film. Further, it can be seen that the ultraviolet protective agent, which is the emulsified composition of the present invention, is excellent in the effect of improving the durability of the ultraviolet protective agent.

[0018]

[Table 3]

Example 7 Production Example An anti-inflammatory agent was prepared according to the following formulation. That is, each of A and B was heated and dissolved at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, followed by stirring and cooling to obtain an anti-inflammatory agent having a refreshing usability. I Behenyl alcohol 2 parts by weight Methacryl-modified methylpolysiloxane 1 part by weight Decamethylcyclopentasiloxane 14 parts by weight Indomethacin 2 parts by weight butylparaben 0.1 part by weight propylene glycol 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methylparaben 0.1 part by weight Carbopol 1382 1 part by weight Potassium hydroxide 1 part by weight Water 68 parts by weight C Aluminum stearate treated titanium dioxide 2.5 parts by weight

Example 8 Phototoxicity Assay Hartley white guinea pig (male 300-350)
g) Toxicity was examined using 6 animals. That is, the back was shaved, and a total of six 2 × 2 cm portions were prepared, three on the left and right, and symmetrically, 0.2 ml of the sample of Example 7 and 0.2 ml of vaseline containing 2% indomethacin (Comparative Example 7) And 0.2 ml of distilled water (control) was applied at two locations. Cover the left side with aluminum foil, shine light only on the right side, and apply 80mW / c with the same number of BLB lamps and SE lamps.
Adjust so that the amount of energy of m2 hits the back,
Irradiated for minutes. Twenty-four hours after irradiation, skin reactions were determined according to Draize's criteria. That is, ++: reaction with edema,
+: Reaction with obvious erythema, ±: reaction with indistinct erythema,-: normal criterion. The results are shown in Table 4 as the number of appearance cases. This indicates that the emulsified composition of the present invention suppresses the appearance of phototoxicity.

[0021]

[Table 4]

Example 9 Production Example An antifungal agent was prepared according to the following formulation. That is, A and B were each heated and melted at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, and the mixture was stirred and cooled to obtain an antifungal agent having a refreshing usability. I-Behenyl alcohol 2 parts by weight Methacryl-modified methylpolysiloxane 5 parts by weight Decamethylcyclopentasiloxane 14 parts by weight Butenafine 2 parts by weight butylparaben 0.1 part by weight propylene glycol 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methylparaben 0.1 parts by weight Pemulen TR-1 0.2 parts by weight Pemulen TR-2 0.3 parts by weight Potassium hydroxide 0.5 parts by weight Water 65 parts by weight C Hydrogenmethylpolysiloxane-treated titanium dioxide 2.5 parts by weight

[0023]

According to the present invention, an oil-in-water emulsion having good storage properties can be provided.

Claims (5)

[Claims] 1. An emulsified composition comprising an acrylic acid / alkyl methacrylate copolymer and methacryl-modified methylpolysiloxane. 2. The composition according to claim 1, wherein the content of the acrylic acid / alkyl methacrylate copolymer is 0.01 to 10% by weight.
3. The emulsified composition according to item 1. 3. The emulsion composition according to claim 1, further comprising decamethylcyclopentanesiloxane. 4. The emulsified composition according to claim 1, wherein the emulsified composition is used for a cosmetic or a pharmaceutical composition for external use on the skin. 5. An oil-in-water emulsion,
The emulsion composition according to any one of claims 1 to 4.