JPH10194965A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an emulsion composition useful as a cosmetic or medicinal composition for skin lotion by including an acrylic/methacrylic alkyl ester and lipophilicized powder so as to effect stable dispersion of the powder. SOLUTION: This emulsion composition contains (A) pref. 0.01-10wt.% of an acrylic/methacrylic alkyl ester and (B) pref. 0.01-10wt.% of lipophilicized powder, and, pref. optionally, a hydrocarbon such as vaseline. To obtain the component B, it is preferable that powder such as of titanium dioxide is subjected to either hydrogenmethylpolysiloxane baking or metallic soap coating.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an emulsified composition useful for cosmetics and a pharmaceutical composition for external use on the skin.

[0002]

2. Description of the Related Art In an oil-in-water emulsion, a continuous phase is an aqueous phase,
It is an emulsified form in which the oil phase is dispersed in it, and the continuous phase is the aqueous phase. It is a dosage form widely used in cosmetics and cosmetics. or,
Powders have been widely used in cosmetics and the like as coloring materials or concealing materials. In medicines and the like, it has been used for the purpose of blocking light and protecting active ingredients. Attempts to blend these powders into oil-in-water emulsions have been made for a long time, and various foundations and the like have been developed. Many of these systems use a large amount of soap in order to maintain the dispersion stability of a powder having a large specific gravity. In such a system, the problem that the "wetting" of the compounded powder changes after application and that the appearance color and the application color are greatly different often occurs. In order to improve this, for example, an attempt was made to mix a surface-treated powder such as hydrogen methyl silicone baked powder, but the oil-in-water emulsion composition suffered from the fact that the continuous phase was an aqueous phase. It was difficult to uniformly disperse the surface-treated powder in the emulsion. Also, in oil-in-water emulsion compositions other than soap-based, since the aggregation reaction between the powder and the acrylic acid-based thickener used as an emulsion stabilizer often occurs, most of those which have not yet been commercialized not exist. That is, the appearance of an oil-in-water emulsion composition capable of stably blending a lipophilized powder has been awaited.

On the other hand, an acrylic acid / alkyl methacrylate copolymer is known as a thickener having an emulsifying power, and is used in cosmetics and the like. It is widely used in cosmetics and the like, but it is also possible to use them in combination, or even to obtain an oil-in-water emulsion in which lipophilic powder is dispersed extremely stably by combining them. Not known at all.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of such circumstances, and it is an object of the present invention to provide an oil-in-water emulsion in which lipophilic treated powder is stably dispersed.

[0005]

In view of such circumstances, as a result of intensive studies, it has been found that an emulsified composition containing an acrylic acid / alkyl methacrylate copolymer can stably disperse lipophilic powder. And completed the invention. Hereinafter, the present invention will be described in detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION

(1) Acrylic acid / alkyl methacrylate copolymer used in the present invention Many acrylic acid / alkyl methacrylate copolymers used in the present invention are commercially available. For example, Pemulen TR manufactured by Goodrich Co., Ltd. -1, Pemulen TR-2,
Carbopol 1382 can be exemplified, and any of them can be used. In the present invention, it is preferable to include Pemulen TR-1. Two or more of these can be used. Although it can be used as it is as a free form, it can also be used in the form of a salt. In the present invention, it is particularly preferred to use as a salt. The salt can be used without any particular limitation as long as it is physiologically acceptable, for example, an alkali metal salt such as sodium and potassium, an alkaline earth metal such as magnesium and calcium,
Organic amine salts such as triethylamine and triethanolamine, ammonium salts, and basic amino acid salts such as lysine and arginine can be preferably exemplified. Of these, use as a potassium salt is particularly preferred. In the present invention, these may be used alone or in combination of two or more. The preferred content of the acrylic acid / alkyl methacrylate copolymer in the emulsified composition of the present invention is 0.01 to 10% by weight, and 0.05 to 7% by weight based on the whole emulsified composition. Is more preferable, and 0.1 to 5
% By weight is more preferred.

(2) Lipophilic powder used in the present invention The lipophilic powder used in the present invention is titanium dioxide, iron oxide, zinc oxide, ultramarine blue, procyan blue, talc, sericite, A powder such as mica or titanium mica is subjected to lipophilic treatment. Examples of the lipophilic treatment include baking treatment of silicones such as hydrogen methyl polysiloxane and metal such as aluminum stearate and zinc stearate. Examples thereof include those whose surface is coated with soap, those whose surface is coated with an acylated amino acid salt such as acylated glutamate, and those whose surface is modified with fluorohydrocarbon, and any of these can be used. These lipophilic powders are widely marketed and easily available. In the present invention, among these lipophilic powders, it is particularly preferable to use hydrogenmethylpolysiloxane baking powder and metal soap coating powder. These lipophilic powders may contain only one kind or two or more kinds in combination. The preferred lipophilic powder content in the emulsified composition of the present invention is 0.01 to 10
%, More preferably 0.05 to 7% by weight, even more preferably 0.1 to 5% by weight.

(3) Emulsion composition of the present invention The emulsion composition of the present invention is characterized by containing the above-mentioned alkyl acrylate / alkyl methacrylate and a lipophilic powder. As an application of the emulsified composition of the present invention, it is possible to stably disperse the lipophilic treated powder despite having a unique feel of an oil-in-water emulsified composition having a refreshing feel. Examples include cosmetics such as make-up, foundation, and ultraviolet protective agents, and external skin pharmaceutical compositions such as antifungal agents and anti-inflammatory agents. In addition, in a pharmaceutical composition for external use on the skin, it is useful together with a powder to suppress the development of phototoxicity caused by the drug. The emulsion composition of the present invention can contain optional components used in such a preparation other than the above essential components as long as the effects of the present invention are not impaired. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, tallow, triglycerides such as olive oil, cetanol,
Higher alcohols such as oleyl alcohol, fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric interfaces Examples include activators, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, and pigments.
It goes without saying that pharmaceuticals can also contain medicinal ingredients. The emulsion composition of the present invention can be produced by treating these components according to a conventional method. The emulsified composition of the present invention thus obtained is excellent in the feeling of use and is excellent in the stable dispersibility of the lipophilic treated powder.

[0009]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

Example 1 Production Example A cream was prepared according to the following formulation. That is, A and B were each heated and melted at 80 ° C., and C was dispersed in A, and B was gradually added to this to emulsify, and then stirred and cooled to obtain a cream having a refreshing use feeling and a bright complexion. I Behenyl alcohol 2 parts by weight Solid paraffin 5 parts by weight Decamethylcyclopentasiloxane 16 parts by weight butyl paraben 0.1 parts by weight 1,3-butanediol 5 parts by weight glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methyl paraben 0.1 parts by weight Parts Pemulen TR-1 0.9 parts by weight Potassium hydroxide 0.9 parts by weight Water 64.7 parts by weight C Hydrogen methyl polysiloxane treated titanium mica 2 parts by weight

<Example 2> Comparative test The cream of Example 1 and Pemulen T of the cream of Example 1
For Comparative Example 1 in which R-1 and potassium hydroxide were replaced with sodium stearate, the dispersibility was observed and determined under a microscope according to the following criteria. That is, the criterion is ++: very good dispersion, +: good dispersion, ±: slightly aggregated,-: aggregated. In addition, the storage property of the decorative film was tested. That is, four 2 cm × 4 cm sections are provided on the inner side of the upper arm, and 0.02 ml of the sample is applied to each section.
After shunting, a tissue is pressed against to wipe off the water, and a drop of water is dropped on the tissue. The state of the water drop is ++: close to a sphere, +: swelling is clearly recognized, ±: slightly swelling,-: Observation and judgment were made on the basis of unclear climax. The number of cases for studying the storage property of the decorative film was 5 cases. Table 1 shows the results. This indicates that the emulsified composition of the present invention has excellent dispersibility of the lipophilic treated powder and is excellent in maintaining the decorative film.

[0012]

[Table 1]

Example 3 Production Example Under make-up was prepared according to the following formulation.
That is, A and B were each heated and dissolved at 80 ° C., and C was dispersed in A. Then, B was gradually added and emulsified, followed by stirring and cooling to obtain a refreshed under-use make-up. I Behenyl alcohol 2 parts by weight Dimethicone (100 centistokes) 1 part by weight Decamethylcyclopentasiloxane 14 parts by weight Butyl paraben 0.1 part by weight Diglycerin 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methyl paraben 0.1 parts by weight Part Pemlen TR-2 0.5 part by weight Potassium hydroxide 0.5 part by weight Water 71.5 parts by weight Aluminum stearate-coated titanium mica 1 part by weight Hydrogen methyl polysiloxane baked mica 0.5 part by weight Zinc stearate coating Titanium dioxide 0.4 parts by weight Hydrogen methyl polysiloxane baking Bengala 0.1 parts by weight

<Example 4> Comparative test The under-make-up of Example 3 and the under-make-up of Example 3 Powder of Comparative Example 2 was replaced with sodium stearate in the same manner as in Example 2. The dispersibility observation judgment and the retention property of the decorative film were tested. That is, four 2 cm × 4 cm sections are provided on the inner side of the upper arm, 0.02 ml of a sample is applied to each section, a foundation is applied thereon, and the mixture is allowed to stand for 10 minutes, and then rubbed lightly with fingers three times in running water. Was. Press the tissue and wipe off the moisture,
The amount of the remaining foundation was visually observed and determined on the basis of ++: almost remaining, +: clearly remaining, ±: slightly remaining,-: not remaining. The number of cases was five. Table 2 shows the results. This indicates that the emulsified composition of the present invention has excellent dispersibility of the lipophilic treated powder and an effect of maintaining the decorative film. In addition, it can be seen that the under-make-up, which is the emulsion composition of the present invention, is excellent in the effect of improving the holding of the foundation.

[0015]

[Table 2]

Example 5 Production Example An ultraviolet protective agent was prepared according to the following formulation. That is, A and B were each heated and melted at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, followed by stirring and cooling to obtain a refreshing UV protective agent having a feeling of use. Ibehenyl alcohol 2 parts by weight Decamethylcyclopentasiloxane 14 parts by weight 2-ethylhexyl paramethoxycinnamate 5 parts by weight 4 parts by weight 4-tert-butyl-4-methoxybenzoylmethane 2 parts by weight 0.1 parts by weight butylparaben 2 parts by weight liquid paraffin Parts Dipropylene glycol 5 parts by weight Glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methylparaben 0.1 parts by weight Pemulen TR-1 0.3 parts by weight Pemulen TR-2 0.3 parts by weight Potassium hydroxide 0.6 parts by weight Water 62.8 parts by weight C Aluminum stearate treated titanium dioxide 2.5 parts by weight

Example 6 Comparative Test Comparative Example 3 in which the UV protective agent of Example 5 and the UV protective agent of Example 5 such as Pemulen TR-1, Pemulene TR-2 and potassium hydroxide were replaced with sodium stearate. , Dispersibility and retention of the decorative film were tested. That is, four 2 cm × 4 cm sites were provided inside the upper arm, and 0.02 ml of the sample was applied to each site, allowed to stand for 10 minutes, and then rubbed lightly with fingers three times in running water. Press the tissue to wipe off the moisture and visually check the amount of remaining UV protection.
+: Almost remaining, +: Clearly remaining, ±: Slightly remaining,-: Not observed and judged based on the following criteria. The number of cases was five. Table 3 shows the results. This shows that the emulsified composition of the present invention maintains an excellent decorative film. Further, it can be seen that the ultraviolet protective agent, which is the emulsified composition of the present invention, is excellent in dispersibility of the powder and the effect of improving the durability of the ultraviolet protective agent.

[0018]

[Table 3]

Example 7 Production Example An anti-inflammatory agent was prepared according to the following formulation. That is, each of A and B was heated and dissolved at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, followed by stirring and cooling to obtain an anti-inflammatory agent having a refreshing usability. I Behenyl alcohol 2 parts by weight Decamethylcyclopentasiloxane 14 parts by weight Indomethacin 2 parts by weight butyl paraben 0.1 parts by weight Lo dipropylene glycol 5 parts by weight glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methyl paraben 0.1 parts by weight Carbopol 1382 0.6 parts by weight Potassium hydroxide 0.6 parts by weight Water 69.8 parts by weight C Aluminum stearate-treated titanium dioxide 2.5 parts by weight

Example 8 Phototoxicity Assay Hartley white guinea pig (male 300-350)
g) Toxicity was examined using 6 animals. That is, the back was shaved, and a total of six 2 × 2 cm portions were prepared, three on the left and right, and symmetrically, 0.2 ml of the sample of Example 7 and 0.2 ml of vaseline containing 2% indomethacin (Comparative Example 7) And 0.2 ml of distilled water (control) was applied at two locations. Cover the left side with aluminum foil, shine light only on the right side, and apply 80mW / c with the same number of BLB lamps and SE lamps.
Adjust so that the amount of energy of m2 hits the back,
Irradiated for minutes. Twenty-four hours after irradiation, skin reactions were determined according to Draize's criteria. That is, ++: reaction with edema,
+: Reaction with obvious erythema, ±: reaction with indistinct erythema,-: normal criterion. The results are shown in Table 4 as the number of appearance cases. This indicates that the emulsified composition of the present invention suppresses the appearance of phototoxicity.

[0021]

[Table 4]

Example 9 Production Example An antifungal agent was prepared according to the following formulation. That is, A and B were each heated and melted at 80 ° C., and C was dispersed in B. Thereafter, B was gradually added and emulsified, and the mixture was stirred and cooled to obtain an antifungal agent having a refreshing usability. I Behenyl alcohol 2 parts by weight Dimethicone (100 centistokes) 5 parts by weight Decamethylcyclopentasiloxane 14 parts by weight Butenafine 2 parts by weight butyl paraben 0.1 part by weight Lo dipropylene glycol 5 parts by weight glycerin 3 parts by weight Xanthan gum 0.3 parts by weight Methyl paraben 0.1 parts by weight Pemulene TR-1 1.5 parts by weight Potassium hydroxide 1.5 parts by weight Water 63 parts by weight C Hydrogen methyl polysiloxane-treated titanium dioxide 2.5 parts by weight

[0023]

According to the present invention, it is possible to provide an oil-in-water emulsion capable of stably dispersing the lipophilic treated powder.

Claims (5)

[Claims] An emulsified composition comprising an alkyl acrylate / alkyl methacrylate and a lipophilic powder. 2. The emulsion composition according to claim 1, wherein the content of acrylic acid / alkyl methacrylate is 0.01 to 10% by weight. 3. The emulsified composition according to claim 1, wherein the lipophilic treatment of the lipophilic powder is any of hydrogen methyl polysiloxane baking and metal soap coating. 4. The emulsified composition according to claim 1, wherein the emulsified composition is used for a cosmetic or a pharmaceutical composition for external use on the skin. 5. An oil-in-water emulsion,
The emulsion composition according to any one of claims 1 to 4.