JPH10182385A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition having effect for removing coat of tongue for a long period of time by allowing said composition to contain a hydrogencarbonate, a monofluorphosphate and/or an alkali metal fluoride and a specific amount of a fatty acid diethanolamide. SOLUTION: This oral composition for an oral cavity containing in preparations such as dentifrice, mouth-washing agent, oral paste, trouche and chewing gum is obtained by formulating (A) 20-40wt.% of a hydrogencarbonate (e.g. sodium hydrogencarbonate), (B) 100-4000ppm of a monofluorophosphate and/of an alkali metal fluoride (e.g. sodium monofluorophosphate), (C) preferably 0.05-3wt.% of a fatty acid diethanolamide consisting of an (un)saturated fatty acid having 10-18C and, when necessary, (D) a suitable component. For example, when dentifrice is prepared, abrasives, caking additives, thickeners, surfactants, pH-regulating agents, sweetenings, perfumes, bactericides and coloring agents can be formulated thereto as the (D) components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for the oral cavity which has a high tongue coating removal effect and provides an excellent tongue coating removal effect even after long-term storage.

[0002]

2. Description of the Related Art
It is known to blend a plant extract such as rosemary and a copper compound such as copper gluconate and copper citrate in order to impart a bad breath preventing effect to an oral composition such as dentifrice (Japanese Unexamined Patent Publication No. 59-5110, JP-A-1-168610). Further, in order to remove tongue coating which is a main cause of physiological bad breath, an auxiliary tool such as a tongue brush (Japanese Utility Model Application Laid-Open No. 63-1111) is used.
No. 16, Japanese Utility Model Laid-Open No. 5-29490) have also been proposed.

[0003] However, even if the above-mentioned components having the effect of preventing bad breath are used, the action of removing tongue coating (Journal of the Oral Health Society, 46, 482-483 (1996)), which is the main cause of physiological bad breath, is insufficient. Lack of persistence of prevention effect. Further, when physically removing tongue coating with a tongue brush or the like, there is a possibility that the surface of the tongue may be damaged and taste disturbance may occur. Therefore, development of an oral composition that can chemically remove tongue coating efficiently has been desired.

[0004]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to respond to the above demand, and as a result, have found that bicarbonate and monofluorophosphate or alkali metal fluoride can be used. It has been found that a high tongue coating removal effect can be obtained by using it in combination. However, when a bicarbonate is used in combination with a monofluorophosphate or an alkali metal fluoride, it has an excellent tongue coating removal effect immediately after preparation, but the effect is significantly reduced, and the bicarbonate and monofluorophosphate are reduced. It has been found that simply using a salt or an alkali metal fluoride in combination is not practical because the effect is reduced by storage.

[0005] In view of the above, as a result of further study over time, a composition for the oral cavity which does not decrease the effect of removing tongue coating was examined. As a result, the combined use of bicarbonate and monofluorophosphate and / or alkali metal fluoride was further added to fatty acid. By adding diethanolamide, in this case, by using the fatty acid diethanolamide in an amount of 0.05% by weight or more based on the whole composition, a decrease in the effect of removing tongue coating over time is suppressed,
The present inventors have found that an oral composition having a stable tongue coating removal effect over a long period of time can be obtained, and have accomplished the present invention.

Conventionally, bicarbonate, monofluorophosphate, and alkali metal fluoride are known as components of oral compositions, but it is known that both are used in combination for the purpose of removing tongue coating. It is a new finding by the present inventors. In addition, fatty acid diethanolamide is also known as a component of the composition for oral cavity, but the tongue coating removal effect by bicarbonate and monofluorophosphate or alkali metal fluoride is stably exhibited for a long time,
In particular, as shown in the experimental examples described below, the fatty acid diethanolamide has a stable tongue coating removal effect over time, although other nonionic surfactants do not have such a time-dependent stabilization effect of the tongue coating removal effect. Is found by the present inventors for the first time.

Accordingly, the present invention provides a method of using a bicarbonate in combination with a monofluorophosphate and / or an alkali metal fluoride, and adding 0.05 to 3% by weight of a fatty acid diethanolamide to the whole composition. It is intended to provide an oral composition characterized by comprising:

Hereinafter, the present invention will be described in more detail.
As described above, the oral composition of the present invention is obtained by blending a bicarbonate, a monofluorophosphate and a fluorine compound selected from alkali metal fluorides and a fatty acid diethanolamide for the purpose of removing tongue coating. .

Here, as the hydrogen carbonate, a water-soluble salt such as sodium hydrogen carbonate is used. As the fluorine compound, one water-soluble salt such as sodium monofluorophosphate and sodium fluoride is used. They can be used alone or in combination of two or more. In addition, the fluorine compound has a tongue coating removal effect when monofluorophosphate and alkali metal fluoride are used in combination with hydrogen carbonate, and other fluorine compounds such as tin fluoride have no tongue coating removal effect. Things.

In the present invention, the compounding amount of the bicarbonate is 2
The range is preferably from 40 to 40% by weight, particularly preferably from 3 to 20% by weight.
If the amount is less than 2% by weight, a sufficient effect of removing tongue coating may not be obtained. If the amount is more than 40% by weight, a salty taste or the like is strongly exhibited, and the feeling in use may be deteriorated.

The compounding amount of the fluorine compound is 100 to 4000 ppm as fluorine ion, especially 400 to 2 ppm.
A range of 000 ppm is preferred. If the compounding amount is less than 100 ppm, a sufficient tongue coating removal effect cannot be expected and 4000 p
If it exceeds pm, the possibility of fluorosis may occur.

On the other hand, as the fatty acid diethanolamide, it is particularly preferable to use a fatty acid diethanolamide composed of a saturated or unsaturated fatty acid having 10 to 18 carbon atoms from the viewpoint of the temporal stability of the effect of removing tongue coating. Can be used alone or in combination of two or more. Further, the fatty acid may be a mixed fatty acid.

The compounding amount of the fatty acid diethanolamide is preferably in the range of 0.05 to 3% by weight, particularly preferably in the range of 0.1 to 2% by weight. If the amount is less than 0.05% by weight, a stable tongue coating removing effect over time cannot be obtained, and if it exceeds 3% by weight, bitterness and oily smell are developed, and the feeling of use is deteriorated.

The oral composition of the present invention can be produced and applied as a dentifrice such as toothpaste, lubricating toothpaste, liquid dentifrice, mouthwash, oral pasta, troche, chewing gum and the like. In the composition for oral cavity, components can be appropriately compounded in addition to the above-mentioned components in accordance with the type. Taking dentifrice as an example, an abrasive, a binder, a thickener, a surfactant, a pH adjuster, a sweetener, a flavor, a bactericide, a coloring agent, and the like can be compounded. Examples of the abrasive include dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, silicates (amorphous silicic anhydride, crystalline silicic anhydride, aluminosilicate, zirconosilicate, etc.), aluminum oxide, hydroxide Aluminum, resin and the like can be blended. As a binder, sodium carboxymethylcellulose, hydroxyethylcellulose, alginic acid, carrageenan, xanthan gum, gelatin, gum arabic, polyvinyl alcohol,
As a thickening agent such as a thickening silicate, polyethylene glycol, sorbitol, glycerin, propylene glycol and the like can be blended.As a surfactant, anionic surfactant sodium lauryl sulfate, sodium dodecylbenzene sulfonate, Sodium lauryl sulfoacetate, sodium sodium lauroyl sarcosine and the like can be blended, and a nonionic or amphoteric surfactant can be blended. Examples of the pH adjuster include citric acid and salts thereof, phosphoric acid and salts thereof, carbonic acid and salts thereof, malic acid and salts thereof, organic acids and salts thereof such as acetic acid and salts thereof, and saccharin sodium as a sweetener.
As a preservative such as stevioside, paraben or the like is used. As the flavor, l-menthol, carvone, eugenol, anethole, spearmint oil, and peppermint oil can be blended. Examples of the disinfectant include nonionic disinfectants such as triclosan and paraoxybenzoic acid esters, and a cationic disinfectant may also be added.

In each case, conventionally used components can be used in a usual dose.

In the case of a mouthwash, a thickener, a sweetener,
pH adjusters, preservatives, solvents and the like are used, as a thickener, sorbitol, glycerin, propylene glycol,
1,3-butylene glycol, polyoxyethylene glycol, xylit, maltitol, lactit and the like can be blended. Examples of sweeteners include stevioside, stevia extract, repadioside, neohesperidyl dihydrochalcone, acesulfame, thaumatin, glycyrrhizin, glycyrrhizin monoglycoside, hernandsurtin, perillartin, saccharin, saccharin sodium, and the like. Organic acids and salts such as acids and salts thereof, phosphoric acids and salts thereof, malic acid and salts thereof, acetic acid and salts thereof, organic acids and salts thereof, preservatives such as methylparaben, solvents such as ethanol and water, and other components are mixed and mixed. Can be manufactured.

Further, in other oral compositions such as chewing gum, troche and the like, the conventionally used components can be produced in a usual amount and according to a conventional method.

[0018]

The composition for oral cavity of the present invention is excellent in removing tongue coating and exhibits excellent tongue coating removal effect even after long-term high-temperature storage.

[0019]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to experimental examples and examples, but the present invention is not limited to the following examples. In the following examples,% indicates% by weight.

[Experimental Example 1] Samples comprising the components shown in Table 1 were prepared, and the effect of removing tongue coating was evaluated by the following method. Table 1 shows the results. Tongue moss removal effect evaluation method Cut out hamster teak pouch (1 cm square)
Is adhered to a Fuzo nucleatum anaerobically cultured in advance. Next, after washing the adhered bacteria (tongue coating) twice, 3 ml of a sample solution is added, and the mixture is allowed to act while shaking at 37 ° C. for 30 minutes. After discarding the sample solution and washing three times with water, the amount of remaining bacteria is measured. A similar experiment was performed using a sample to which no sample was added as a control, and the tongue coating removal rate was calculated from the following equation based on the amount of adherent bacteria (X ₀ ) at that time and the amount of adherent bacteria (X _s ) when the sample solution was used. Ask.

[0021]

(Equation 1)

[0022]

[Table 1]

From the results shown in Table 1, it was confirmed that the combination of sodium bicarbonate and sodium monofluorophosphate or sodium fluoride had a high tongue coating removal effect.

[Experimental Example 2] A dentifrice having the following formulation was prepared, and its tongue coating removing effect was evaluated by a use test using humans. That is, five adults who have no disease in the oral cavity were set as subjects,
After stopping oral cleaning for 3 days, the samples were brushed for 3 minutes 3 times a day for 3 days. Thereafter, the degree of adhesion of tongue coating was compared according to the following evaluation method. Table 2 shows the results.

[0025]

(Equation 2)

Dentifrice formulation Silicic anhydride 25% Sorbit 30 Sodium lauryl sulfate 2 Flavor 1 Sodium bicarbonate Amount shown in Table 2 Sodium fluoride Amount shown in Table 2 Purified water Balance 100%

[0027]

[Table 2]

From the results shown in Table 2, it was confirmed that the combined use of sodium bicarbonate and sodium fluoride exhibited an excellent tongue coating removal effect.

Experimental Example 3 A dentifrice having the following formulation was prepared.
After storing at 60 ° C. for one month, the effect of removing tongue coating was evaluated using the same method as in Experimental Example 1. Table 3 shows the results. Dentifrice formulation Myristic acid diethanolamide Amount shown in Table 3 Sodium bicarbonate 10% Sodium fluoride 1000 ppm (as F ion) Silicic anhydride 25% Sorbit 30 Sodium lauryl sulfate 2 Fragrance 1 Purified water Balance 100%

[0030]

[Table 3]

When sodium bicarbonate and sodium fluoride were used in combination, the tongue coating was effectively removed as described above.
In the system not containing myristinic acid diethanolamide, the tongue coating removal effect was significantly reduced after storage at 60 ° C. for one month. In contrast, by adding 0.05% or more of myristic acid diethanolamide,
The time-dependent stability of the tongue coating removal effect could be achieved.

[Experimental Example 4] A dentifrice of the following formulation containing the components shown in Tables 4 and 5 was prepared and stored at 60 ° C for one month. evaluated. The results are shown in Tables 4 and 5. Dentifrice formulation Nonionic activator Amount shown in Tables 4 and 5 Fluorine compound Amount shown in Tables 4 and 5 Sodium bicarbonate 10% Silicic anhydride 25 Sorbit 30 Sodium lauryl sulfate 2 Fragrance 1 Purified water Balance 100%

[0033]

[Table 4]

[0034]

[Table 5]

From the results shown in Table 4, the temporal stability of the tongue coating removal effect when sodium bicarbonate and sodium monofluorophosphate or sodium fluoride were used in combination with nonionic activators other than fatty acid diethanolamide was not confirmed. Was. In addition, it was confirmed that the fatty acid diethanolamide, which is composed of a saturated or unsaturated fatty acid having 10 to 18 carbon atoms, is particularly effective. Furthermore, the effect of fatty acid diethanolamide was confirmed at a blending amount of 0.05% or more, and particularly, a high effect was confirmed in the range of 0.1 to 2%.

Examples will be described below. Example 1 Toothpaste Silicic anhydride 25% Carboxymethylcellulose 1 Carrageenan 0.3 Sorbit 30 Propylene glycol 3 Sodium lauryl sulfate 1.5 Sodium bicarbonate 5 Lauric acid diethanolamide 0.5 Sodium fluoride 0.2 Tranexamic acid 0 .1 butyl paraben 0.1 ethyl paraben 0.05 fragrance 0.7 purified water balance 100%

Example 2 Toothpaste Calcium Carbonate 15% Carboxymethyl Cellulose 1 Glycerin 30 Propylene Glycol 3 Sodium Lauryl Sulfate 1.5 Tocopherol Acetate 0.1 Sodium Bicarbonate 20 Myristate Diethanolamide 1.0 Sodium Monofluorophosphate 0 .7 Ethylparaben 0.1 Triclosan 0.1 Perfume 1.2 Purified water Balance 100%

Example 3 Toothpaste Silicic anhydride 16% Xanthan gum 1 Sorbit 15 Glycerin 10 Polyethylene glycol 5 Sodium lauryl sulfate 2 Sodium bicarbonate 5 Palmitic acid diethanolamide 2 Sodium monofluorophosphate 0.3 Sodium fluoride 0. 1 dipotassium glycyrrhizinate 0.1 methyl paraben 0.2 fragrance 0.8 purified water balance 100%

Example 4 Toothpaste Aluminum hydroxide 30% Sodium alginate 1 Carrageenan 0.3 Sorbit 20 Glycerin 10 Propylene glycol 3 POE hydrogenated castor oil 3 Triclosan 0.3 Sodium bicarbonate 15 Sodium monofluorophosphate 0.75 Stearic acid diethanolamide 1.5 Tocopherol acetate 0.1 Sodium benzoate 0.5 Perfume 1.5 Purified water Balance 100%

[Example 5] Liquid dentifrice Silicic anhydride 15% Sodium polyacrylate 0.5 Xanthan gum 0.2 Sorbit 30 Propylene glycol 3 Sucrose fatty acid ester 2 Dipotassium glycyrrhizinate 0.05 Dextranase 0.1 Triclosan 0 0.3 sodium bicarbonate 10 lauric acid diethanolamide 0.5 sodium fluoride 0.2 sodium saccharin 0.1 ethyl paraben 0.1 fragrance 0.5 purified water balance 100%

Example 6 Liquid Toothpaste Silicic Anhydride 10% Sodium Alginate 0.5 Xanthan Gum 0.2 Glycerin 25 Polyethylene Glycol 3 Sodium Lauryl Sulfate 1.2 Oubaku Extract 0.76 Sodium Bicarbonate 20 Sodium Monofluorophosphate 1 Lauric acid diethanolamide 0.3 Methyl paraben 0.18 Saccharin sodium 0.1 Fragrance 0.6 Purified water Balance 100%

Example 7 Liquid Dentifrice Carboxymethyl Cellulose 0.3% Xanthan Gum 0.3 Glycerin 35 Propylene Glycol 2 Sodium Lauryl Sulfate 3 Sodium Bicarbonate 5 Sodium Monofluorophosphate 0.3 Sodium Fluoride 0.2 Diethanolamine Oleate De 0.8 β-glycyrrhetinic acid 0.1 methyl paraben 0.1 cineole 0.2 1-menthol 0.5 flavor 0.5 purified water balance 100%

Example 8 Mouthwash Ethanol 20% POE Cetyl Ether 3 Triclosan 0.1 Sodium Bicarbonate 2 Sodium Monofluorophosphate 0.1 Myristic Acid Diethanolamide 0.3 Fragrance 0.2 Purified Water Residue 100%

Example 9 Mouthwash Glycerin 20% Ethyl Alcohol 15 POE Hardened Castor Oil 2 Sodium Bicarbonate 5 Sodium Monofluorophosphate 0.1 Myristate Diethanolamide 0.3 Fragrance 0.7 Purified Water Balance 100 %

Example 10 Chewing Gum Chickle 20% Vinyl Acetate 10 Glycerin 10 Triclosan 0.1 Sodium Bicarbonate 10 Sodium Monofluorophosphate 0.3 Lauric Diethanolamide 0.5 Fragrance 2 Multitose Balance 100%

Claims (1)

[Claims] 1. A combination of bicarbonate, monofluorophosphate and / or alkali metal fluoride, and 0.05 to 3% by weight of fatty acid diethanolamide based on the whole composition. An oral composition.