JPH10179711A - Medical plaster - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve sweat absorption, adhesion property and easy release property by compounding specified amts. of styrene rubber, acryl polymer, isopropyl myristate and polyoxyalkylene glycol having specified mol.wt. to form an adhesive layer. SOLUTION: This medical plaster essentially consists of a base body and an adhesive layer. The adhesive layer consists of 100 pts.wt. styrene rubber, 80 to 120 pts.wt. acryl polymer, 60 to 80 pts.wt. isopropyl myristate, and 30 to 120 pts.wt. polyoxyalkylene glycol having >=300mol.wt. The styrene rubber preferably has 700 to 1500cPs soln. viscosity (at 25 deg.C in 25wt.% toluene soln.), and the acryl polymer is preferably an alkyl (meth)acrylate having 3 to 8wt.% acrylic acid component. The isopropyl myristate acts as a softening agent and also accelerates to release a medical component from the adhesive layer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical patch, and more particularly, to a transdermal absorbable preparation, an adhesive bandage, a bandage, etc., which are excellent in sweat absorbency, adhesiveness and peelability. The present invention relates to a medical patch.

[0002]

2. Description of the Related Art Conventionally, a large number of medical patches, such as transdermal absorption preparations containing a drug in an adhesive layer, have been produced. When these patches are applied to the skin for a long time,
Often, stuffiness causes skin softening, rash, redness, and rash. This is because the pressure-sensitive adhesive layer and the support constituting the medical patch have poor sweat absorbency. For example, a medical patch having a pressure-sensitive adhesive layer composed of a synthetic rubber having cohesive strength, a tackifying resin having adhesive strength, isopropyl myristate functioning as a softening agent, and a drug indomethacin, which has been proposed as a patch containing indomethacin, has been proposed. Japanese Unexamined Patent Publication No. Hei 8-133972) also has excellent tackiness, but does not satisfy sweat absorption.

On the other hand, JP-A-6-256183 reports that when a polyoxyalkylene glycol is added as a softening agent to a pressure-sensitive adhesive layer, the sweat-absorbing property of the pressure-sensitive adhesive layer can be enhanced. However, the pressure-sensitive adhesive layer comprising a synthetic rubber, a tackifier resin and a polyoxyalkylene glycol as a softener has an excellent sweat-absorbing property, but has a problem that adhesive residue is easily generated, and conversely, the adhesive strength is weakened.

[0004]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a medical adhesive material which has good sweat-absorbing properties and excellent adhesiveness and ease of peeling.

[0005]

It is expected that if isopropyl myristate and polyoxyalkylene glycol are used in combination as a softener, a pressure-sensitive adhesive layer excellent in both sweat absorption and tackiness may be formed. . However, although the above-mentioned softener is used in combination with the synthetic rubber and the tackifier resin, the pressure-sensitive adhesive layer has excellent sweat-absorbing properties, but it is still apt to leave glue residue, indicating that the adhesive strength is insufficient. Was.

As a result of extensive studies, the present inventors have shown that not only the use of isopropyl myristate and polyoxyalkylene glycol as a softening agent but also the use of an acrylic polymer provides excellent sweat-absorbing properties. Thus, a medical patch having satisfactory adhesiveness and peelability has been obtained.

That is, the present invention relates to a medical patch comprising a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises 100 parts by weight of styrene rubber, 80 to 120 parts by weight of acrylic polymer, and 60 to 120 parts by weight of isopropyl myristate. 80 parts by weight, polyoxyalkylene glycol 3 having a molecular weight of 300 or more
A medical patch comprising 0 to 120 parts by weight.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The medical patch of the present invention mainly comprises a support and an adhesive layer. Such a support can be formed with a pressure-sensitive adhesive layer on at least one surface thereof, and there is no particular limitation as long as the substrate has self-holding properties, and a release material.For example, polyethylene terephthalate, polyesters such as polyethylene naphthalate, polyoxyalkylene glycol and A film comprising a polymer such as a polyether ester, a polyolefin, or a cellulose ester comprising the polyester; a woven / knitted / nonwoven fabric comprising the above-mentioned polyester, polyolefin, cellulose ester, polyurethane, polyamide, etc .; , Cellulose esters, polyurethanes, polyamides, etc .; porous membranes coated with a release agent such as silicone, fluorine, etc. Le, can be mentioned a film made of polyamide. These may be used alone or in combination of two or more. The thickness of these supports is
In the case of a substrate, usually 50 mm to 300 mm, preferably 70 mm
~ 200mm, 3mm ~ 100m for mold release
m, preferably 5 mm to 50 mm.

The pressure-sensitive adhesive layer is made of styrene rubber 100
Parts by weight, 80 to 120 parts by weight of acrylic polymer, 60 to 80 parts by weight of isopropyl myristate, molecular weight 300
The above polyoxyalkylene glycol 30-12
Consists of 0 parts by weight. The composition of the pressure-sensitive adhesive layer is such that the acrylic polymer is 80 to 100 parts by weight of the styrene rubber.
It is 120 parts by weight, preferably 90 to 110 parts by weight. If it is less than 80 parts by weight, the adhesiveness is weak, and if it exceeds 120 parts by weight, adhesive residue is apt to be generated when the adhesive is peeled off. The isopropyl myristate is a styrene rubber 100
60 to 80 parts by weight, preferably 6 to 80 parts by weight.
5 to 75 parts by weight. When the amount is less than 60 parts by weight, the peelability of the skin is poor, and when the amount is more than 80 parts by weight, adhesive residue tends to be generated when the adhesive is peeled off. The polyoxyalkylene glycol is used in an amount of 30 to 120 with respect to 100 parts by weight of the styrene rubber.
Parts by weight, preferably 50 to 100 parts by weight.
If it is less than 30 parts by weight, the sweat absorption is poor, and if it exceeds 120 parts by weight, the polyoxyalkylene glycol tends to exude from the pressure-sensitive adhesive layer.

The styrene rubber used in the present invention is not particularly limited. For example, styrene-isoprene block copolymers such as styrene-isoprene block copolymer and styrene-isoprene-styrene block copolymer; styrene Styrene-butadiene block copolymers such as butadiene block copolymers and styrene-butadiene-styrene block copolymers. Above all, a styrene content of 10 to 30% by weight, particularly 15% by weight
% Of styrene-isoprene-styrene block copolymer is preferable because it has an appropriate rubber elasticity.

The styrene rubber has a solution viscosity of 700.
Those which are 〜1500 cps (25 ° C., 25% by weight toluene solution) are preferred.

The acrylic polymer used in the present invention is mainly composed of alkyl (meth) acrylate having 1 to 20 carbon atoms, preferably 10% by weight.
Hereinafter, a (meth) acrylic acid alkyl ester copolymer containing more preferably 3 to 8% by weight of an acrylic acid component is preferable. Among these, a copolymer containing an acrylic acid component in an amount of 3 to 8% by weight and containing 2-ethylhexyl acrylate and butyl acrylate in a weight ratio of 50: 1 to 1:10 has a large adhesive force and an adhesive. It is more preferable because polyoxyalkylene glycol is prevented from seeping out of the layer.

The number average molecular weight (in terms of polystyrene) of the acrylic polymer is preferably 500 to 8000.
It is.

The isopropyl myristate used in the present invention is preferable because it functions as a softener and, at the same time, contains a drug in the pressure-sensitive adhesive layer, because it promotes the release of the drug from the pressure-sensitive adhesive layer. In addition to the above-mentioned isopropyl myristate, oils and fats such as olive oil and castor oil as softeners; higher fatty acid esters such as isopropyl palmitate, ethyl oleate and diethyl sebacate; linolenic acid, linoleic acid, oleic acid, capric acid, etc. Higher fatty acids; fatty acid esters such as diethyl phthalate and diisopropyl adipate. These softeners are desirably added within a range that does not impair the cohesive strength, adhesive strength, and the like of the pressure-sensitive adhesive layer.

In the patch according to the present invention, polyoxyalkylene glycol is used in combination with isopropyl myristate as a softening agent. The polyoxyalkylene glycol has a repeating structure of oxyalkylene units having 2 to 4 carbon atoms, and specific examples include polyethylene glycol, polypropylene glycol, and polybutylene glycol. As the polyoxyalkylene glycol, a block copolymer of polyoxyalkylene glycol or a derivative thereof may be used. Examples of the polyoxyalkylene glycol block copolymer include a polyoxyethylene glycol-polyoxypropylene glycol block copolymer. Examples of the polyoxyalkylene glycol derivative include a polyoxyethylene glycol-polyoxypropylene glycol block condensate of ethylenediamine.

Among these polyoxyalkylene glycols, among these, a polyoxyethylene glycol-polyoxypropylene glycol block copolymer and a polyoxyethylene glycol-polyoxypropylene glycol block condensate of ethylenediamine are preferably used. .

The polyoxyalkylene glycol preferably has a number average molecular weight of 300 or more. If the molecular weight is 300 or less, there is a possibility of permeation into the substrate. Preferred molecular weights are from 1,000 to 20,000. The polyoxyalkylene glycol is desirably added within a range that does not exude from the pressure-sensitive adhesive layer, and the addition amount is preferably 30 to 120 parts by weight based on 100 parts by weight of the styrene rubber.

The pressure-sensitive adhesive layer in the present invention is prepared by mixing and dissolving the styrene rubber, acrylic polymer, isopropyl myristate, and polyoxyalkylene glycol with a common solvent, and then applying the mixture to one surface of a substrate or a release material. Thereafter, the solvent can be removed by a drying treatment to obtain the pressure-sensitive adhesive layer. The thickness of the completed pressure-sensitive adhesive layer is usually preferably in the range of 10 mm to 200 mm. For example, when a drug is contained, it depends on the drug used, but usually 2 mm.
0 mm to 100 mm, preferably about 30 mm to 80 mm is suitable.

The adhesive material of the present invention can be obtained by directly or indirectly laminating the support and the pressure-sensitive adhesive layer obtained as described above, or by directly applying the pressure-sensitive adhesive to the support, for example, by using a quarter-water adhesive. It can be obtained by a conventionally known method such as coating using an adhesive or the like, or transferring an adhesive layer on a support.

In the present invention, the pressure-sensitive adhesive layer may contain a drug. The drug to be contained is not particularly limited,
A fat-soluble drug that can be dissolved in the pressure-sensitive adhesive layer is preferable. Specifically, anti-inflammatory analgesics, steroids, antihypertensive diuretics, anesthetics, antihistamines, antitumor agents, antihypertensives, antidepressants,
And fat-soluble vitamins. These are added in the adhesive layer in an amount of 3 to 40% by weight, preferably 5 to 30% by weight. As a method for containing a drug, a drug solution is preliminarily mixed with a solution-type pressure-sensitive adhesive to form a drug-containing pressure-sensitive adhesive layer, or the drug is not contained by a method such as impregnation, transfer, spraying, or the like. Conventionally known methods can be employed depending on the physical properties of the drug to be contained, such as by allowing the pressure-sensitive adhesive layer not sufficiently containing the drug to contain the drug in an amount sufficient for transdermal absorption.

[0021]

According to the present invention, it is possible to obtain a medical patch which is excellent in sweat absorption, excellent in adhesiveness and excellent in ease of peeling. Such a medical patch is suitably used for an adhesive bandage, a bandage, and the like, and is suitably used as a transdermal preparation by containing a drug in the adhesive layer.

[0022]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to the examples.
The properties of the patch were evaluated by the following methods.

(Moisture) Affixed to the chest of five adult men,
The softening of the skin after 3 hours was evaluated by a score according to the following criteria.

0 point: no whitening 3 points: slight whitening 5 points: whitening Evaluation was made based on the average score of five persons.

(Irritation) The rash was applied to the chest of five adult men, and the degree of erythema of the skin 24 hours later was evaluated by a score according to the following criteria.

0 point: no erythema 1 point: very mild erythema 2 points: clear erythema 4 points: strong erythema

(Peel off) Five adult males were stuck on the elbows for 24 hours, and the average value of the five persons was shown as 100% when the whole was peeled off, and 0% when the whole was not peeled off.

(Peeling operability) Five adult males were stuck inside the upper arm, peeled 30 minutes later, and their pain was measured. The evaluation was performed on a scale of 1 to 5, and the average score was determined with one having the least pain as one point and the one with the least difficulty being peeled as five points.

Example 1 Styrene-isoprene-styrene block copolymer having a styrene content of 15% by weight (solution viscosity: 1000 cps) and a chloroform solution of 10% by weight in chloroform 100
0 parts by weight, 2-ethylhexyl acrylate 9
A copolymer (number average molecular weight 5000) of 3% by weight, 2% by weight of butyl acrylate and 5% by weight of acrylic acid (number average molecular weight 5000) 1000% by weight of ethyl acetate solution, 70% by weight of isopropyl myristate, and polypropylene glycol-polyethylene glycol Block copolymer (molecular weight 1
After adding 70 parts by weight (500, manufactured by Sanyo Chemical Co., Ltd.), this mixed solution was applied onto release paper so that the thickness of the dried adhesive layer was 50 mm, and the adhesive layer was dried. A 3.5 mm polyethylene terephthalate (PET) film and a surgical tape were adhered to one surface of the thus obtained pressure-sensitive adhesive layer as a support to obtain a patch. As shown in Table 1, the results were good in both sweat absorption and adhesiveness.

COMPARATIVE EXAMPLE 1 A chloroform solution containing 10% by weight of a styrene-isoprene-styrene block copolymer 1
2,000 parts by weight of an aliphatic saturated hydrocarbon resin (ESCO
Attached in the same manner as in Example 1 except that 1000 parts by weight of a 10% by weight chloroform solution, 70 parts by weight of isopropyl myristate, and 70 parts by weight of a polypropylene glycol-polyethylene glycol block copolymer were used. Materials were prepared. As a result, as shown in Table 1, the adhesive strength was weak.

Comparative Example 2 A chloroform solution containing 10% by weight of a styrene-isoprene-styrene block copolymer 1
Except that 1000 parts by weight of a 10% by weight copolymer of 2-ethylhexyl acrylate, butyl acrylate and acrylic acid of Example 1 in ethyl acetate and 70 parts by weight of isopropyl myristate were used for 000 parts by weight. In the same manner as in Example 1, a patch was prepared. As shown in Table 1, the results were not good in sweat absorption.

[0032]

[Table 1]

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Takeyuki Kawaguchi 2-1 Hinodecho, Iwakuni-shi, Yamaguchi Prefecture Teijin Limited Iwakuni Research Center

Claims (1)

[Claims] 1. A medical patch comprising a support and an adhesive layer, wherein the adhesive layer comprises 100 parts by weight of styrene rubber, 80 to 120 parts by weight of an acrylic polymer, and 60 to 80 parts by weight of isopropyl myristate. A medical patch comprising 30 parts by weight and 30 to 120 parts by weight of a polyoxyalkylene glycol having a molecular weight of 300 or more.