JPH10158183A - Composition for preventing and treating hangover - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for improving or preventing dysphoria such as retching, nausea, headache, hangover and malaise resulting from acetaldehyde after alcohol intake. SOLUTION: This composition comprises an extract of garlic, ginseng, civet, preferably bezoar, pyridoxine and panthenol and as active ingredients. The composition is administered before or after taking an alcohol to improve or prevent dysphoria after taking an alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to compositions for ameliorating or preventing acetaldehyde discomfort after alcohol consumption.

BACKGROUND ART Conventionally , discomfort symptoms such as gastrointestinal musk, nausea, headache, and hangover after alcohol consumption are caused by acetaldehyde which is a metabolite of alcohol. Therefore, it is important to quickly remove acetaldehyde from the blood after alcohol consumption (Katsuji Harada, Body Science, No. 21, 85-89, 1989;
Noriaki Nakamura, Genetics, 49, 58-63, 1995).

[0003] However, in order to improve these discomfort symptoms, the method conventionally used is indirect treatment such as protection of the gastric mucosa mainly by gastrointestinal drugs or neutralization of gastric acid.

[0004]

SUMMARY OF THE INVENTION The present inventors have now found that various combinations of crude drugs and vitamins can promote the metabolism of acetaldehyde after ingestion of alcohol. The present invention is based on this finding.

Accordingly, an object of the present invention is to provide a composition for improving or preventing unpleasant symptoms such as muskock, nausea, headache, hangover, and malaise due to acetaldehyde after ingestion of alcohol.

The composition for improving or preventing discomfort after alcohol consumption according to the present invention comprises garlic extract, carrot and civet as active ingredients.

[0007]

DETAILED DESCRIPTION OF THE INVENTION The crude drug described herein below means a crude drug component generally referred to by the name used herein. That is, even if the place of origin and base are different, it means that any crude drug within the range that can be evaluated as equivalent by the name used in this specification can be used in the present invention. For example, Japanese Color Book of Primary Colors by Kazuo Namba (published by Nursery Co., Ltd., 1980), Dictionary of Chinese Medicine (Edited by Shanghai Science and Technology Publishing Co., Ltd., published by Shogakkan Co., Ltd., 1985) (Hakutakakan Co., Ltd., 1988).

[0008] The composition according to the present invention comprises a garlic extract,
It contains carrots and civet as active ingredients.

In the present invention, the garlic extract means garlic extracted with water or hydrous ethanol, usually extracted with water-containing ethanol at room temperature for several days to several months, or several months to several years. What has been subjected to extraction and aged can be used. In some cases, after heating garlic in an aqueous solution, iron oxide is added to the squeezed squeezed juice, water-soluble proteins are removed, and processed garlic obtained by further removing fructan is used as an extract. You may.

[0010] The carrot is, for example, a root excluding fine roots of Panax ginseng, a lightly blanched root thereof, or a steamed root thereof.

[0011] Civet is a secretion obtained from the incense sac of a civet, for example.

[0012] These components are usually drugs or crude drugs,
Any form used in the field of herbal medicine, for example, bulk powder, extract, tincture and the like can be used.

The composition ratio of these components in the composition according to the present invention may be appropriately determined within a range in which the effects of the present invention described later can be obtained. For example, the compositions shown in the following table are preferable in terms of weight ratio.

[0014]

By taking the composition according to the present invention before or after ingesting alcohol, it is possible to ameliorate or prevent the discomfort symptoms after ingesting alcohol. Specifically, it can improve or prevent nausea, muskiness, nausea, headache, hangover, malaise, etc. after alcohol intake.

The mechanism of action of the present invention will be described on the condition that the present invention is not construed as limiting. The composition according to the present invention has an effect of enhancing the activity of acetaldehyde dehydrogenase in liver mitochondria. Seem.

According to a further preferred embodiment of the present invention, the composition according to the present invention preferably further comprises gourd, locust, pyridoxine and panthenol. By further adding these components, it is possible to improve or prevent the discomfort symptoms after alcohol consumption.

Here, gooh is a stone formed in the gallbladder of a cow.

"Rokujou" refers to non-keratinized juvenile horns of A. deer, Siberian deer, or A. deer.

Pyridoxine is 5-hydroxy-6-methyl-
3,4-pyridinedimethanol, that is, vitamin B6, and any salt is preferable, and a phosphate or a hydrochloride can be used.

According to a preferred embodiment of the present invention, the composition ratio of these components may be appropriately determined within a range in which the effects of the present invention described later can be obtained, and for example, the compositions described in the following table by weight ratio are preferable. .

[0022]

The composition according to the present invention can be prepared by mixing, for example, excipients, binders, diluents and the like in the preparation into powders, granules, tablets,
It can be prepared into any dosage form such as capsules and liquids. Preferably, a flavoring agent, a sweetening agent and the like are added to make a drink.

[0024] The composition according to the present invention may optionally contain other drug components.

The dose can be appropriately increased or decreased depending on the age, body weight, symptoms, etc. Usually, the total amount of the above active ingredients is about 1 to 6 g once or several times a day. it can.

It should be noted that garlic, which is the main component in the composition according to the present invention, is usually used for food, and other components are used as components of the nutritional tonic, etc.
Generally low toxicity.

[0027]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Example 1: Internal preparation An internal preparation composition according to the present invention was prepared by mixing the following components.

[0029] Table 3 Ingredient Ginseng soft extract 0.2g garlic extract 1.6ml Goouchinki 0.2ml civet tincture 0.05ml good jaw tincture 0.2ml pyridoxine hydrochloride 50.0mg panthenol 10.8mg sweeteners qs flavoring Qs purified water qs total 50ml

Experimental Example 1 The protective effects of garlic extract, carrot extract and civet tincture against the lethal effect of acetaldehyde were evaluated as follows.

First, a group of ddY male mice (7 weeks old)
After fasting overnight, the animals were orally administered a drug sample (20 ml / kg), and 1 hour later, acetaldehyde (450 mg / kg) was intraperitoneally administered. Observations were made daily until 7 days after administration of acetaldehyde, and the mortality was calculated.

The experimental group was a group administered with the composition according to the present invention (ie, a group administered with garlic extract-carrot extract-civet tincture), a control group (administered with distilled water), a group administered with garlic extract alone, or a group administered with carrot extract alone. , And civet tincture alone. The drug doses were: garlic extract 0.64 ml / kg, carrot extract 80 mg / kg, civet tincture 0.02 ml / kg
These were dissolved in water and administered.

The survival rate up to 7 days after administration of acetaldehyde was as shown in the following table.

Table 4 Survival rate (%) of group to which the composition of the present invention was administered 40.0% * Control group 0% Garlic extract alone group 15.8% Carrot extract alone group 21.2% * Civet tincture Single group 17.2% (*) (*), *: p <0.1, 0.05

As is clear from the table, the garlic extract,
Both carrots and civet reduced mortality from acetaldehyde. Furthermore, the survival rate was further improved in the group administered with the composition according to the present invention. The three components garlic extract, carrot extract and civet tincture were found to synergistically protect against acetaldehyde death.

Experimental Example 2 The protective effect of the oral preparation of Example 1 on the lethal effect of acetaldehyde was evaluated as follows.

First, a group of ddY male mice (7 weeks old), 10
After fasting overnight, the animals were orally administered a drug sample (20 ml / kg), and 1 hour later, acetaldehyde (450 mg / kg) was intraperitoneally administered. Observations were made daily until 5 days after administration of acetaldehyde, and the mortality was calculated.

The experimental group includes two groups: a group administered with the liquid composition of the present invention, and a control group (administered with distilled water).

The survival rate and survival time up to 5 days after the administration of acetaldehyde were as shown in the following table.

Table 5 Group to be administered Survival rate (%) Survival time (hr) Example 1 administration group 70% ** 93.6 ± 14.1 ** Control group 0% 7.3 ± 5.1 ** : P <0.01

As is clear from the table, the survival rate was remarkably improved to 70%, which was a significant improvement compared with the case of only the three components of garlic extract, carrot extract and civet tincture shown in Example 1 above. The effect was further enhanced.

EXPERIMENTAL EXAMPLE 3 The oral preparation of Example 1 and compositions A to
The protective effect of C against the lethal effect of acetaldehyde was examined. These compositions A to C are gastrointestinal compositions generally conventionally known.

Table 6 Composition A Licorice extract 60 mg Gentian tincture 188 μl Spiny tincture 413 μl Calyx tincture 125 μl Caudin tincture 63 μl Carrot stream extract 250 μl Sojutsu stream extract 600 μl dl-Carnitine chloride 60 mg Total 25 ml

Table 7 Composition B Licorice extract 70 mg Gentian tincture 188 μl Auricular tincture 413 μl Aurora tincture extract 100 μl Calyx tincture 125 μl Chowtin tincture 63 μl Carrot tincture 150 μl Carrot flow extract 250 μl Soujutsu flow extract 600 μl dl-carnitine chloride 60 ml 25 mg

Table 8 Composition C Synthetic hydrotalcite 400 mg Oxoamidine powder 30 mg Carrot dried extract 90 mg Ouren flow extract-B 0.3 ml Ginger flow extract 0.3 ml Goshuyu flow extract 0.3 ml Soujutsu flow extract 0.4 ml Ursodeoxycholic acid 15 mg Licorice Extract powder 86mg total amount 50ml

The experiment was performed as follows.

First, a group of ddY male mice (7 weeks old), 10
After fasting overnight, the animals were orally administered 10 ml / kg of a drug sample, and 1 hour later, 450 mg / kg of acetaldehyde was intraperitoneally administered. Observations were made daily until 8 days after administration of acetaldehyde, and the mortality was calculated.

The experimental groups were a group to which the oral medicine of Example 1 was administered, a group to which the above three gastrointestinal drug compositions were administered, and a control group (to which distilled water was administered).

The survival rate and survival time up to 8 days after administration of acetaldehyde were as shown in the following table.

Table 9 Survival rate (%) Survival time (hr) Example 1 administration group 70% ** 141.6 ± 25.7 * Composition A administration group 30% 98.4 ± 23.3 Composition B administration group 30% 74.4 ± 25.7 Composition C administration group 50% * 122.4 ± 26.9 Control group 0% 60.0 ± 15.3 *, **: p <0.05 , 0.01

As is evident from the table, the composition according to the invention showed a stronger protective effect against acetaldehyde than the conventionally known gastrointestinal drugs.

Experimental Example 4 The effect of the oral preparation of Example 1 on blood ethanol concentration was evaluated as follows.

First, a group of ddY strain male mice (7 weeks old), 10
After fasting overnight, the animals were orally administered with a drug sample (20 ml / kg), orally with ethanol (3 g / kg) 30 minutes later, and 0.5, 1, 3, 4, and 6 hours after administration under posterior ether anesthesia. Blood was collected from the vein. The blood ethanol concentration was measured using a blood ethanol measurement kit (Boehringer).

The experimental group was the two groups of the internal medicine administration group of Example 1 and the control group (distilled water administration).

The blood ethanol concentration after the administration of ethanol was as shown in FIG.

As is clear from FIG. 1, the ethanol concentration in the control group reached the maximum value 30 minutes after administration of ethanol, then gradually decreased, and then reached the minimum value 6 hours later. The same change was observed in the group to which the composition according to the present invention was administered. After 30 minutes, although it was slightly higher than that in the control group, it did not show a clear effect on blood ethanol concentration.

Experimental Example 5 The effect of the oral preparation of Example 1 on blood acetaldehyde concentration was evaluated as follows.

First, a group of ddY male mice (7 weeks old), 10
After fasting overnight, the animals were orally administered with a drug sample (20 ml / kg), and 1 hour later, acetaldehyde (300 mg / kg) was intraperitoneally administered, and blood was collected from the posterior vena cava under ether anesthesia 2, 5, 15 and 30 minutes after administration. did. The blood acetaldehyde concentration was measured using a blood ethanol measurement kit (Boehringer).

The experimental group is the two groups of the internal medicine administration group of Example 1 and the control group (distilled water administration).

The blood ethanol concentration after administration of acetaldehyde was as shown in FIG.

As is clear from FIG. 2, the blood acetaldehyde concentration 2 minutes after administration of acetaldehyde was not different between the two groups, but was significantly greater in the group administered with the composition according to the present invention 5 minutes later than in the control group. It was low and has remained low since then. From this, it has been clarified that the composition according to the present invention promotes the disappearance of acetaldehyde in blood.

Experimental Example 6 The effect of the oral preparation of Example 1 on the activity of acetaldehyde dehydrogenase in mitochondria extracted from mouse liver was evaluated in vitro as follows.

First, male ddY mice (10 weeks of age) were fasted overnight, sacrificed by decapitation, and their livers were removed. The method of Nakanishi (Tetsuo Sato et al., Toxicity Test Lecture 6, 236-240, Jinjinshokan, Tokyo, 1989) to prepare a mitochondrial fraction and measure acetaldehyde dehydrogenase. Example 1
The three internal doses of 0.63, 1.25, and 2.5 μl / ml were added.

The measurement results of the acetaldehyde dehydrogenase activity were as shown below.

Table 10 Experimental group Acetaldehyde dehydrogenase activity (nmol NADH formed / mg protein / min) oral preparation 0.63 μl / ml 2.29 ± 0.10 oral preparation 1.25 μl / ml 2.23 ± 0.39 oral administration 2.5 μl / ml 2.54 ± 0.09 * control group 2.08 ± 0.10 *: p <0.05

From the above results, the composition according to the present invention was
It was clarified to increase its activity against acetaldehyde dehydrogenase in liver mitochondria in vitro.

Experimental Example 7 The effect of the oral preparation of Example 1 on the activity of acetaldehyde dehydrogenase in mitochondria of mouse liver was evaluated as follows.

First, a male ddY strain mouse (10 weeks old) was fasted overnight, and then a drug sample (20 ml / kg) was orally administered.
After hours, the animals were sacrificed by decapitation and their livers were removed. About the excised liver, the method of Nakanishi (Tetsuo Sato et al., Toxicity test course 6,
236-240, Jinjinshokan, Tokyo, 1989) to prepare a mitochondrial fraction and measure acetaldehyde dehydrogenase.

The experimental group is the two groups of the internal medicine administration group of Example 1 and the control group (distilled water administration).

The results of measurement of acetaldehyde dehydrogenase activity were as shown below.

Table 11 Experimental group Acetaldehyde dehydrogenase activity (nmol NADH formed / mg protein / min) Control group 1.62 ± 0.11 Oral administration group 2.48 ± 0.39 * *: p <0. 05

From the above results, the composition according to the present invention is:
It was also shown that the activity of acetaldehyde dehydrogenase in liver mitochondria was increased in vivo.

[Brief description of the drawings]

FIG. 1 is a graph showing the effect of the composition of the present invention on blood alcohol concentration over time in Experimental Example 4.

FIG. 2 is a graph showing the time-dependent effect of the composition of the present invention on blood acetaldehyde concentration in Experimental Example 5. In the table, (*) represents p <0.1.

 ──────────────────────────────────────────────────の Continued on the front page (72) Shigeo Kasuga, Inventor 1624 Shimodate, Koda-cho, Takada-gun, Hiroshima Prefecture Yukinaga Pharmaceutical Co., Ltd. Yukinaga Pharmaceutical Co., Ltd.

Claims (4)

[Claims] 1. A composition for improving or preventing discomfort after alcohol consumption, comprising a garlic extract, carrot and civet as active ingredients. 2. The composition according to claim 1, further comprising gourd, locust, pyridoxine, and panthenol. 3. The composition according to claim 1, wherein the discomfort symptoms after alcohol consumption are nausea, musky, nausea, headache, hangover, or malaise. 4. The composition according to claim 1, wherein the composition is a pharmaceutical composition.
A composition according to any one of the preceding claims.