JPH10151174A - Infusion container for instillation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an infusion container for communicating a drug container and a dissolving fluid container to each other in a single operation. SOLUTION: This container has a container body 1 fitted with a fluid delivery means 4 containing a dissolving fluid and having an elastic plug 3 on a lower end for allowing a puncture with an infusion needle and an air supply needle, as well as a separation means 10 with the container body 1 at a lower end opening in such a state as jointed to the upper part of the container body 1. In addition, the container is formed out of a liquid-tight holder 5 having an intermediate separation part compressively deformable, an inverted vial 6 housed in the holder 5 and formed to have the periphery of a mouth 6a temporarily held on a projection formed on the inner surface of a lower fixed holder 5b to form the holder 5 and have a rubber intermediate plug 7 forcibly inserted in the mouth 6a, and an unplugging means 11 laid within the space of the lower fixed holder 5b formed between the inverted vial mouth 6a and the separation means 10 so as to release the separation means 10 and communicate the container body 1 and the vial 6 to each other on the descending motion of an upper movable holder 5a.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention belongs to the technical field of an infusion container for infusion.

[0002]

2. Description of the Related Art Conventionally, as an infusion container for infusion of this kind, a flexible container having a liquid passage portion containing a dissolving solution or a diluent therein and having a closed film at the uppermost end, A connected capsule, a medicine container whose mouth is sealed with a pierceable stopper, and held in the capsule; and a communication means for communicating between the inside of the flexible container and the inside of the medicine container. The communicating means comprises a hollow puncture needle having a hub in the middle and having a cutting edge at both ends, and after the stopper of the drug container is pierced by one of the puncture needles, the other blade of the puncture needle And a braking means for controlling the order of communication so that the closing membrane of the flexible container is pierced by the device. (See, for example, JP-A-2-1277)

[0003]

In such a conventional technique, since the means for communicating the inside of the flexible container and the inside of the medicine container is formed by a hollow puncture needle, the liquid that exchanges the liquid between them is used. Is small, the dissolution rate of the drug is slow and it takes a lot of time, and the structure is complicated, the cost is high, and it is uneconomical.

An object of the present invention is to provide one-touch operation for communication between a drug container and a dissolving solution container, a large exchange of liquid between the two chambers, rapid dissolution of the drug, and an improvement in infusion efficiency. It is to provide an infusion container which can achieve the above.

[0005]

The object of the present invention is to provide a flexible resin in which a dissolving solution is accommodated inside and a discharge means having an elastic stopper at the lower end through which a drip injection needle and a ventilation needle can be pierced. A lower body fixed to a container main body made of a material, an upper movable holder connected to an upper part of the container main body, provided with means for isolating the container main body at an opening at a lower end, and a liquid-tight structure capable of compressively deforming a middle part. Holder longer than the vial composed of the holder and accommodated in the holder, and the projection around the inner surface of the lower fixed holder that constitutes this holder temporarily supports the periphery of the bottle opening and can be pushed into the bottle opening Inverted position vial plugged with a rubber stopper, and the lower fixed holder space formed between the inverted vial opening and the isolation means, by the lowering operation of the upper movable holder This is achieved by the fact that a rubber inner plug that can be plugged into the vial bottle opening is pushed into the vial to open it, the isolating means is released, and the container body and the opening means for communicating the vial are constituted. The object of the present invention is to provide, in claim 1, the opening means provided on the upper surface of a disk temporarily supported by a projection provided on the inner surface of the lower fixing holder and in contact with or near the lower surface of the rubber inner stopper. A pusher body, a needle bar that is initially punctured by penetrating the center of an isolating means provided in the center of the lower surface of the disk, a plurality of concentric cylinders whose outer circumferences are reduced toward the outer side, and a disk; This is achieved by providing the separating means with a cleavable diaphragm structure. The object of the present invention is to provide, in claim 1, the opening means in contact with a disk temporarily supported by a projection provided on the inner surface of the lower fixing holder and a lower surface of a rubber inner plug provided on the upper surface of the disk. Or, a pusher that is close to the disk, a projection group that forms a liquid passage gap provided on the lower surface of the disk, and a liquid hole that communicates with the pusher provided on the disk, while the isolation means is provided with an opening means A rubber packing which is liquid-tightly fitted in the middle of the lower fixing holder below the lower fixing holder, and a plurality of liquid passage grooves formed on the lower inner surface of the lower fixing holder and communicating with the inside of the container body. Is achieved. The object is as described in any one of claims 1 to 3, wherein the liquid discharging means is placed above the elastic stopper provided thereon.
This is achieved by providing a filtering means for removing foreign matter such as debris generated by cleavage of the separating means having a diaphragm structure.

[0006]

Embodiments of the present invention will be described with reference to the drawings. 1 is a partially cutaway front view showing a first embodiment of the infusion container of the present invention, FIG. 2 is a partially cutaway enlarged front view showing a medicine vial uncommunicated posture, and FIG. 3 is a partially enlarged view showing a medicine vial communicating posture. 4 is a bottom view of the opening means, FIG. 5 is a bottom view of the diaphragm, FIG. 6 is a partially cutaway front view showing the second embodiment of the infusion container, and FIG. 7 shows a non-communicating posture of the drug vial. 8 is a partially cut-away enlarged front view, FIG. 8 is a partially cut-away enlarged front view showing the communicating posture of the drug vial, FIG. 9 is an overhead perspective view of the opening means,
FIG. 10 is an elevation perspective view of the opening means.

The first embodiment of the present invention will be described in detail with reference to FIGS. A is an infusion container main body for drip injection, and the infusion container main body A is a container main body 1 in which a solution is stored.
And a medicine container 2 in which a medicine vial connected to the upper part thereof is accommodated.

The container body 1 is formed by heat-sealing two flexible single-layer or composite resin films 1a. A drip injection needle (not shown) and a vent are provided at the lower end of the container body 1. Rubber stopper 3 through which needle (not shown) can be inserted
Is liquid-tightly heat-sealed 1c.

The medicine container 2 connected to the upper side of the container body 1 is connected to the medicine container 2 by a heat seal 1b of the resin film 1a, and has an upper movable holder 5a having a cylindrical cap structure and a lower fixed holder. 5b is accommodated. Upper movable holder 5a
And the outer periphery of the lower fixed holder 5b are respectively thermally welded 1d to the resin film 1a. Upper movable holder 5
a and the upper half of the lower fixed holder 5b have substantially the same diameter as the vial 6 housed therein, and the lower half of the lower fixed holder 5b has substantially the same diameter as the vial 6a diameter of the vial 6. Is formed. A push-on rubber plug 7 is plugged into the vial 6 a of the vial 6. In the figure, reference numeral 8 denotes a suspension ring, and 1e denotes a compressively deformable portion formed by the resin film 1a.

[0010] The vial intervention cylinder 5 constituting the holder 5
c engages with the inner surface of the upper portion of the vial 6a.
Is provided, and a rupturable diaphragm 10 is stretched over the lower end opening of the vial intervention cylinder 5c. As shown in FIG. 5, the diaphragm 10 has an easily cleavable thin portion 10a radially developed from the center on the back surface, and is integrally formed so as to be radially cleaved from the center toward the outer periphery. is there.

Reference numeral 11 denotes an opening member constituting an opening means. The opening member 11 is configured as follows. That is, a protrusion 5d is provided on a relatively lower inner surface of the vial intervention cylinder portion 5c, on which the periphery of the disk 11a constituting the plug 11 is locked and the plug 11 is temporarily supported, and the upper surface of the disk 11a is provided. 2, bottle mouth 6
A cylindrical pusher 11b having a diameter smaller than the diameter of a and abutting or approaching the lower surface of the rubber inner plug 7 is integrally formed. on the other hand,
A relatively long needle 11c is provided at the center of the lower surface of the disk 11a and pierced into the center of the diaphragm 10 for initial puncture, and the height of the needle 11c is gradually reduced as it reaches the outer periphery and the outer side of the needle 11c. A plurality of cylinders 11d are provided concentrically, and a large number of liquid holes 11e are formed in the disk 11a near the pushing body 11b, the needle rod 11c, and the cylinder 11d as shown in FIG. The body 11 is configured as described above.

A filter member 12 for removing foreign matters such as debris generated by cleavage of the diaphragm 10 is provided on the upper part of the discharged liquid 4.
Is installed. The filter member 12 can be provided with a sterilizing or sterilizing function by filtering bacteria or the like.

Upper movable holder 5 constituting holder 5
The distance between the lower end of a and the upper end of the lower fixing holder 5b is substantially the same as or slightly longer than the length between the upper surface of the disk 11a constituting the plug 11 at the lower limit position where the projection 9 and the diaphragm 10 are cleaved. It is desirable to do.

[0014]

[Explanation of Handling] In the case of injecting a drip into a patient, for example, when the lower fixed holder 5b is gripped by the left hand finger and a lowering operation is applied to the upper movable holder 5a with the right hand, the vial 6a of the vial 6 is opened. The engagement relationship by the projection 9 is released and the projection 9 descends. Rubber stopper 7 by lowering vial 6
Is strongly pressed by the pushing body 11b of the opening body 11,
The rubber plug 7 is forcibly pushed into the vial 6, and the plug of the vial 6 is released. At the same time, when the opening body 11 is lowered, the center of the diaphragm 10 is initially cleaved by the needle rod 11c provided at the center of the lower surface of the opening body 11, and then the diaphragm 10 is instantaneously metabolized by the pressing and tearing action of the plurality of cylindrical bodies 11d. Are also radially cleaved and opened, and the inside of the vial 6 and the inside of the container body 1 are communicated. The lysing solution in the container body 1 flows into the vial 6, the drug is dissolved by the lysing solution, and the obtained drug solution is instilled by a conventional method. At this time, foreign substances such as fragments generated by the cleavage of the diaphragm 10 are completely removed by the filter member 12, and only the active drug component is instilled into a human body or the like.

Next, a second embodiment of the present invention will be described in detail with reference to FIGS. The second embodiment is different from the first embodiment only in the configuration of the opening means and the communicating means, and the other configurations are the same. Therefore, the detailed description is omitted by attaching the same reference numerals to the same structural parts. I do.

Reference numeral 21 denotes an opening member constituting opening means, and the opening member 21 is configured as follows. That is, on the inner surface of the intermediate portion of the vial intervention cylindrical portion 5c, the periphery of the disk 21a forming the plug 21 is locked, and a projection 5d for temporarily supporting the plug 21 is provided, and the upper surface of the disk 21a is provided. A cylindrical pushing body 21b, which is smaller in diameter than the diameter of the bottle opening 6a and is in contact with or close to the lower surface of the rubber inner plug 7, is integrally formed, and a liquid passage hole 21c adapted to the inner diameter of the pushing body 21b is formed. It is provided at the center of the disk 21a. On the other hand, a protruding ridge 21e for forming a radial liquid passage 21d is integrally formed on the lower surface of the disk 21a avoiding the liquid passage hole 21c, and is formed on the upper surface of the disk 21a on the outer periphery of the pushing body 21b. The stopper 21g is integrally formed with the ridge 21g constituting the radial liquid passage 21f, and the plug 21 is configured as described above.

A rubber packing provided on the lower surface of the stopper 21, more specifically, on the lower surface of the ridge portion 21 e formed on the lower surface of the disk 21 a, in a liquid-tight manner and can also be lowered to the vial intervention cylinder portion 5 c. 22 is brought into contact with the rubber packing 2
A plurality of liquid passage grooves 23 along the axis of the vial intervention cylindrical portion 5c below the lower surface of the vial intervention cylinder portion 5c are formed at equal intervals.

As shown in FIG. 8, a ridge 21e provided on the lower surface of the disk 21a is provided between the upper surface of the rubber packing 22 and the lower surface of the disk 21a constituting the plug 21. The liquid passage 21d communicating with the liquid groove 23 is formed, and the disc 2 is formed.
The ridge portion 21g provided on the upper surface of 1a forms the liquid passage 21f communicating with the liquid passage groove 23 between the surface of the bottle opening 6a and the upper surface of the disk 21a.

The length of the compression interval between the lower end of the upper movable holder 5a constituting the holder 5 and the upper end of the lower fixed holder 5b, more specifically, the length of the compressively deformable portion 1e is greater than the length of the vial intervention cylinder 5c. Formed short, vial 6
The rubber packing 22 is prevented from dropping off from the lower end of the vial intervention cylinder portion 5c at the lower limit of the lower limit.

[0020]

[Explanation of Handling] In the case of injecting a drip into a patient, for example, when the lower fixed holder 5b is gripped by the left hand finger and a lowering operation is applied to the upper movable holder 5a with the right hand, the vial 6a of the vial 6 is opened. The engagement relationship by the projection 9 is released and the projection 9 descends. Rubber stopper 7 by lowering vial 6
Is strongly pressed by the pushing body 21b of the opener 21,
The rubber plug 7 is forcibly pushed into the vial 6, and the plug of the vial 6 is released. At the same time, the rubber packing 22 also moves down due to the lowering of the plug 21, and the rubber packing 22 that has moved down to the lower limit of the plug 21 reaches the lower part of the vial intervention cylinder 5 c having the liquid passage groove 23 and is stopped. . In this state, the inside of the container body 1 and the inside of the vial 6
3. The communication is established through the liquid passages 21d and 21f and the liquid passage holes 21c. The lysing solution in the container body 1 flows into the vial 6, the drug is dissolved by the lysing solution, and the obtained drug solution is instilled by a conventional method. At this time, foreign substances and the like generated by sliding down of the rubber packing 22 and the like are completely removed by the filter member 12, and only the effective drug component is instilled into a human body or the like.

[0021]

According to the configuration of the present invention as described above,
The following effects can be obtained. (A) As compared with the prior art in which a medicine container and a solution container are communicated with each other by a puncture needle, the rubber inner stopper is pushed into the vial by one-touch pushing operation, and the vial and the container body are connected at once. The dissolution of the drug is performed quickly, improving the drip efficiency.At the same time, the rubber stopper of the vial is easily pushed into the vial by the opening means following the lowering of the vial, and at the same time, the accurate Communication between the vial and the container body can be achieved, the configuration is simple, and long-term stable storage of the drug and the solution is guaranteed. (B) Debris and other foreign matter generated by the opening of the diaphragm or sliding down of the rubber packing can be completely removed by the filter member, and there is no fear that the foreign matter is injected into the body.

[Brief description of the drawings]

FIG. 1 is a partially cutaway front view showing a first embodiment of the infusion container of the present invention.

FIG. 2 is a partially cutaway front view showing a non-communicating posture of a drug vial.

FIG. 3 is a partially cutaway enlarged front view showing a communicating posture of a medicine vial.

FIG. 4 is a bottom view of the opening means.

FIG. 5 is a bottom view of the diaphragm.

FIG. 6 is a partially cutaway front view showing a second embodiment of the infusion container.

FIG. 7 is a partially cut-away enlarged front view showing a non-communicating posture of the medicine vial.

FIG. 8 is a partially cut-away enlarged front view showing a communicating posture of a medicine vial.

FIG. 9 is an overhead perspective view of the plug opening means.

FIG. 10 is an elevation perspective view of the opening means.

[Explanation of symbols]

 A Infusion container main body 1 Container main body 1a Single-layer or composite resin film 1b Heat seal 1c Heat welding 1d Heat welding 1e Compressible deformable part 2 Drug container 3 Rubber stopper 4 Discharge liquid 5 Holder 5a Upper movable holder 5b Lower fixed holder 5c Vial intervention Tube part 6 Vial 6a Bottle opening 7 Rubber stopper 8 Suspension ring 9 Protrusion 10 Diaphragm 10a Thin part with easy tearing 11 Opener 11a Disk 11b Pusher 11c Needle rod 11d Cylindrical body 12 Filter member 21 Opening means 21a Disc 21b Push body 21c Liquid passage hole 21d Liquid passage 21e Ridge 21f Liquid passage 21g Ridge 22 Rubber packing 23 Liquid passage groove

Claims (4)

[Claims] 1. A container body made of a flexible resin material, in which a dissolving solution is accommodated inside and a liquid discharging means provided with an elastic stopper at the lower end through which a drip injection needle and a ventilation needle can be pierced, and a container A vial composed of an upper movable holder and a lower fixed holder, connected to the upper part of the main body and provided with a means for isolating from the container main body at the lower end opening, and an intermediate part connected by a liquid-tight structure that can be compressed and deformed. Inverter that is housed in a holder, and the periphery of the bottle opening is temporarily supported by projections formed on the inner surface of the lower fixed holder that constitutes this holder, and a rubber plug that can be pushed into the bottle opening is plugged. The vial in the posture and the space in the lower fixed holder formed between the vial opening in the inverted posture and the isolation means can be plugged into the vial opening by the lowering operation of the upper movable holder. And an opening means which pushes the inner stopper into the vial to open it, releases the isolating means, and connects the container body to the vial. 2. The method according to claim 1, wherein the opening means is provided on an upper surface of a disk temporarily supported by a projection provided on an inner surface of the lower fixing holder, and is in contact with or near a lower surface of the rubber inner stopper. A pusher body, a needle bar that pierces the center of an isolating means provided at the center of the lower surface of the disk, and that initially cleaves; a plurality of concentric cylinders that are shorter on the outer periphery of the needle bar as they reach the outer side; An infusion container for drip injection, wherein the infusion means comprises a liquid passage hole provided in the plate, and the isolation means has a rupturable diaphragm structure. 3. The plug opening means according to claim 1, wherein the opening means is provided on a disk temporarily provisionally supported by a projection provided on the inner surface of the middle part of the lower fixing holder, and on a lower surface of a rubber inner stopper provided on an upper surface of the disk. A push body that is in contact with or close to the disk, a projection group that forms a liquid passage gap provided on the lower surface of the disk, and a liquid hole that communicates with the push body provided on the disk, while the isolation means is opened. A rubber packing liquid-tightly fitted to the middle part of the lower fixed holder below the means, and a plurality of liquid passage grooves formed on the lower inner surface of the lower fixed holder and communicating with the inside of the container body. An infusion container for intravenous drip injection, characterized in that 4. In any one of claims 1 to 3,
An infusion container for drip injection, characterized in that the liquid discharging means is provided with a filtering means for removing foreign matter such as debris generated by cleavage of the separating means having a diaphragm structure, above the elastic stopper provided thereon.