JPH06125969A - Chemical container set - Google Patents

Abstract

PURPOSE:To provide a chemical container set comprising a small number of parts in which a chemical can be mixed with dissolving liquid sterilely in easy operation without requiring much labor. CONSTITUTION:A chemical container set comprises a chemical container 1 comprising a container main body 11, and a rubber cap 13 for closing a mouth part 12 of the container main body 11, and a capsule 2 for containing the chemical container 1, the capsule 2 has a bottom 21 and an open end, a communication means 4 capable of sliding up and down is provided at an open end part, and the open end is sealed with a cover member 5. When the communication means 4 is moved down, the chemical container 1 communicates with the external by effect of the communication means 4.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a drug container set. More specifically, dry drugs such as powdered preparations, freeze-dried preparations, and solid preparations and their dissolved solutions are stored in a separated state, and the dried drug and the dissolved solutions are aseptically mixed in a container immediately before use. The present invention relates to a drug container set including a combination of a capsule and a drug container, which is provided with a communicating means for supplying as a liquid drug.

[0002]

2. Description of the Related Art Conventionally, in medical institutions such as hospitals, a dried drug contained in a drug container such as a vial is dissolved in distilled water, a saline solution, a solution such as glucose solution (including other drug solutions), and then an intravenous injection is made. It is used for In order to easily use in such a case, the vial containing the dry drug is connected in series to the flexible container containing the solution,
An infusion container has been proposed in which a rubber needle of both containers is pierced by a puncture needle (referred to as a double-ended needle) having puncture portions at both ends of a hollow needle at the time of use so that these two containers can be aseptically communicated with each other. Table 61-501129, Japanese Patent Laid-Open No. 2-12
77 gazette, Jitsukai 63-135642 gazette, etc.).

The one disclosed in Japanese Patent Publication No. 61-501129 is that in which a capsule containing a drug container and a flexible container containing a solution are connected by a tube, which is provided in the tube. The medicine container and the flexible container are communicated with each other by the communication means so that the medicine and the solution are aseptically mixed. In addition, JP-A-2-1277
What is disclosed in the publication is that the capsule containing the drug container is connected to the mouth of the dissolution liquid container at its connecting portion, and the connecting means having the connecting sequence regulating means is interposed on the connecting portion side of the capsule. In, after the drug container is pierced by the communication means, the dissolution liquid container is pierced and the two containers are communicated, and the drug and the dissolution liquid are aseptically mixed,
The one disclosed in Japanese Utility Model Laid-Open No. 63-135642 is a cylindrical support ring that is detachably attached to the sealing portion at the mouth of the solution container, and a double-ended needle is attached to this support ring so that it can slide up and down. In addition, when the double-ended needle is slid downward, the lower puncture needle punctures the seal part at the mouth of the solution container.

[0004]

Among the above-mentioned conventional infusion containers, the one disclosed in Japanese Utility Model Laid-Open No. 63-135642 is an infusion container with a communicating means, and a vial which is a general distribution form of dry chemicals. It includes the one that is captured and integrated as it is. Further, those disclosed in Japanese Patent Publication No. 61-501129 and Japanese Patent Application Laid-Open No. 2-1277 are:
All of them are vials, which are a general distribution form of dry chemicals, and are integrated as they are, and in that sense, they are highly versatile. However, the special table Sho 61-501129
The infusion container of Japanese Patent Publication has a large number of parts, and it takes time to fold the breaking member by hand to open the passage. It has the drawback of being time consuming, and it is also difficult to achieve this.
The infusion container of -1277 is considerably improved in comparison with the infusion container of JP-A-61-501129 in respect of prevention of contamination of internal medicine and simplification of communication between the medicine container and the dissolution container. However, there are drawbacks in that the parts such as the communication order regulating means are complicated and the number of parts is large as a whole.
The infusion container of JP-A-3-135642 has a small number of parts and is relatively easy to operate, but requires a relatively large force for communication. After mixing the drug and the solution, the support ring and the double-ended needle are removed to dissolve the solution. Since it is necessary to invert the container and connect an infusion set etc. to the seal part at the mouth of the dissolution liquid container after removing the double-ended needle, it takes time and labor for operation, and there is a risk that the mixed drug solution will leak when the double-ended needle is removed. There is
It has drawbacks such as

The present invention has been made in view of the above circumstances, and is an improvement over the conventional drug container, which is easy to operate, hassle-free, has a small number of parts, and is aseptically mixed with a solution. An object of the present invention is to provide a drug container set that can be manufactured.

[0006]

In order to solve the above-mentioned problems, the present invention provides a drug comprising a bottomed cylindrical container body having a reduced diameter mouth portion and a rubber stopper for closing the mouth portion of the container body. A container and an assembly composed of a bottomed cylindrical capsule for accommodating the drug container, the capsule having a communication means slidable in a vertical direction along an inner wall of the capsule at an open end thereof, The open end is sealed by a cover member, and when the communicating means is moved downward, the drug container is configured to be communicated with the outside by the communicating means. And as a preferable combination of the rubber stopper and the communication means, it has an upper closed portion and a lower communication portion, and has a chemical liquid passage that penetrates along the central axis thereof, and the chemical liquid passage of the closed portion is closed by a closing body. ,
A rubber stopper having a groove or slit formed in the drug solution passage of the communicating portion so that the drug solution passage opens when the closing body moves, a puncture needle on the upper part and a lower part having a drug solution passage running vertically. A combination of a communication tube composed of a push rod and a communication means composed of a cup-shaped hub for vertically and slidably mounting the communication tube vertically on the inner wall of the capsule (first combination) ), A normal rubber stopper, and a double-headed needle having a vertically extending chemical solution passage, which separates the double-sided needle vertically and a cup-shaped hub for vertically and slidably attaching to the inner wall of the capsule. A combination (second combination) with the communication means provided is adopted.

[0007]

According to the above construction, the rubber plug and the communication means are the first.
In the case of the combination of, remove the cover member from the capsule,
Apply the rubber stopper at the mouth of the solution container to the puncture needle on the upper part of the communication tube of the communication means and push it down. Then, the inside of the container body and the chemical liquid passage of the communication pipe communicate with each other through the groove (or slit) formed in the chemical liquid passage of the communication portion. On the other hand, the rubber stopper at the mouth of the dissolution liquid container is pierced by the puncture needle of the communication pipe, and the inside of the dissolution liquid container communicates with the drug solution passage of the communication pipe, so that the drug container is the dissolution liquid container through the communication pipe. Communicate with.

In the case of the second combination of the rubber stopper and the communicating means, the cover member is removed from the capsule, and the rubber stopper at the mouth of the dissolution liquid container is applied downward to the puncture needle above the double-ended needle of the communicating means. When pushed down, the rubber stopper at the mouth of the drug container is pierced by the puncture needle below the double-ended needle, and the inside of the drug container and the drug solution passage of the double-ended needle communicate with each other. On the other hand, the rubber stopper at the mouth of the solution container is pierced by the puncture needle above the double-ended needle, and since the inside of the solution container and the drug solution passage of the double-ended needle communicate, the drug container dissolves through the double-ended needle. Communicate with the liquid container.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, a medicine container with a communicating means of the present invention will be described with reference to the drawings. 1 is a cross-sectional view of a drug container set according to one embodiment of the present invention, and FIG. 2 is a cross-sectional view of the drug container shown in FIG. 3 is a sectional view showing another embodiment of the present invention. As shown in FIGS. 1 to 3, the drug container set of the present invention contains a drug container 1 including a container body 11 and a rubber stopper 13 or 16 for closing an opening 12 of the container body 11, and the drug container 1. The capsule 2 is provided with a communication means 4 (in the case of the rubber plug 13) or 6 (in the case of the rubber plug 16) slidable in the vertical direction at the open end thereof, and the open end is the cover member 5. It is sealed. When the communication means 4 or 6 is moved downward, the medicine container 1 is communicated with the outside by the communication means 4 or 6.

First, the case of the drug container set shown in FIGS. 1 and 2 will be described. Unlike a normal rubber stopper, the rubber stopper 13 that closes the mouth portion 12 of the container body 11 which is usually made of glass is different from a normal rubber stopper, and a chemical liquid passage 133 that penetrates the rubber stopper along the central axis thereof.
And has a closing part 131 at the top and a communication part 13 at the bottom.
It consists of 2. And the chemical liquid passage 13 of the closing part 131
3 is closed by a closing body 14, and a groove (not shown) or a slit 135 is formed in the chemical liquid passage 133 of the communication portion 132. This groove (or slit 13
In 5), the chemical liquid passage 133 is opened when the closing body 14 moves to this portion, and usually 2 to 4 pieces are formed. The closing body 1 is provided in the chemical liquid passage 133 of the communication part 132.
A bulge 134 as shown in FIG. 1 may be formed in conformity with the shape of No. 4. Reference numeral 15 is a caulking member made of aluminum or the like, and after the rubber stopper 13 is plugged into the mouth portion 12 of the container body 11, the flange 136 of the closing portion 131 is crimped to the mouth portion 12, It is used to securely fix the rubber stopper 13 to the mouth portion 12. As a material for forming the rubber plug 13, generally, butyl rubber, butadiene rubber, styrene-
Butadiene rubber and isoprene rubber are used.

The closing body 14 for closing the chemical liquid passage 133 of the rubber stopper 13 has an outer shape larger than the inner diameter of the chemical liquid passage 133, and is usually formed of glass or synthetic resin in a spherical or columnar shape. The forming material is not particularly limited as long as it has a smooth surface and chemical resistance.

The drug container 1 having the above structure is housed in a cylindrical capsule 2 having a bottom 21 with the mouth 12 facing upward.
The capsule 2 is usually formed of a synthetic resin such as polypropylene, polyethylene, polyester, or polyvinyl chloride into a tubular shape, and is provided with a communicating means 4 at the upper open end thereof.
The open end is sealed and protected by a cover member 5. An annular groove 22 is formed on the inner wall of the open end of the capsule 2 close to the open end, and the hub 4 of the communication means 4 described later is formed.
By engaging with a convex portion 422 formed at the lower end of the second skirt 421, the communication means 4 is prevented from falling off or being inadvertently moved downward. Incidentally, 3 is a packing that seals between the open end of the capsule 2 and the cover member 5, and in FIGS. 1 and 3, the cover member 5 is screwed onto the capsule 2. The material for forming the cover member 5 is not particularly limited, but polyethylene, polypropylene, polyester, or the like is suitable.

The communication means 4 is composed of a communication tube 41 and a cup-shaped hub 42 that separates the communication tube 41 from each other vertically. The communication means 4 is usually integrally formed of a synthetic resin such as polypropylene, ABS resin or polycarbonate, and the open end portion of the capsule 2 is formed. It is provided on the inner wall of the unit so as to be vertically slidable in the vicinity of the open end. The communication pipe 41 usually has one or two vertically extending drug solution passages 413, and is composed of an upper puncture needle 411 and a lower push rod 412. The attachment of the communication means 4 to the capsule 2 is performed by the skirt 421 of the hub 42 in the middle thereof, and the skirt 42 of the hub 42 is attached.
The annular or plural hemispherical protrusions 422 formed on the lower end of the capsule 1 and protruding outward are engaged with the annular groove 22 formed on the upper end of the capsule 2. Hub 4
The engagement between the capsule 2 and the capsule 2 may be performed by forming an annular groove in the outer wall of the skirt 421 of the hub 42 and the protrusion formed on the inner wall of the capsule 2.

Next, the case of the medicine container set shown in FIG. 3 will be described. This drug container set has exactly the same configuration as the drug container set of FIG. 1 except for the double-ended needle 61 of the communicating means 6 and the rubber stopper 16 of the drug container 1.
That is, the communication means 6 includes a double-ended needle 61 and a cup-shaped hub 62.
The double-ended needle 61 normally has one or two vertically extending drug solution passages 613, and the upper puncture needle 6
11 and a lower puncture needle 612. The attachment to the capsule 2 is performed by the skirt 621 of the hub 62 in the middle thereof, and the annular or plural hemispherical projections 622 formed on the lower end of the skirt 621 of the hub 62 and protruding outward 622 and the capsule 2 are provided. The annular groove 22 formed at the upper end of the is engaged. Also,
As the rubber stopper 16 for sealing the mouth portion 12 of the medicine container 1, a usual one that can be pierced by the lower puncture needle 612 of the double-ended needle 61 is adopted.

[0014]

As is apparent from what has been described above, by adopting the drug container with the communicating means of the present invention, the aseptic mixing operation with the solution is easy and does not require much labor. Since the number of parts is small, the quality of the product is stable, and the manufacturing cost is low, so that it is possible to inexpensively provide a high-quality drug container with a communication means. You can get advantages such as.

[Brief description of drawings]

FIG. 1 is a cross-sectional view of a drug container with a communicating means according to an embodiment of the present invention.

FIG. 2 is a cross-sectional view taken along line XX of the drug container shown in FIG.

FIG. 3 is a sectional view showing another embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Chemical | medical agent container 11 Container body 13 Rubber stopper 131 Closing part 132 Communication part 133 Chemical liquid passage 135 Slit 14 Closing body 15 Caulking member 16 Rubber stopper 2 Capsule 4 Communication means 41 Communication pipe 411 Puncture needle 412 Push rod 413 Chemical liquid passage 42 Hub 5 cover Member 6 Communication means 61 Double-ended needle 611 Upper puncture needle 612 Lower puncture needle 613 Chemical liquid passage 62 Hub

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[Procedure amendment]

[Submission date] December 10, 1992

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] Claim 2

[Correction method] Change

[Correction content]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction content]

[0006]

In order to solve the above-mentioned problems, the present invention provides a drug comprising a bottomed cylindrical container body having a reduced diameter mouth portion and a rubber stopper for closing the mouth portion of the container body. A container and an assembly composed of a bottomed cylindrical capsule for accommodating the drug container, the capsule having a communication means slidable in a vertical direction along an inner wall of the capsule at an open end thereof, The open end is sealed by a cover member, and when the communicating means is moved downward, the drug container is configured to be communicated with the outside by the communicating means. And as a preferable combination of the rubber stopper and the communication means, it has an upper closed portion and a lower communication portion, and has a chemical liquid passage that penetrates along the central axis thereof, and the chemical liquid passage of the closed portion is closed by a closing body. ,
A rubber stopper having a groove or slit formed in the drug solution passage of the communicating portion so that the drug solution passage opens when the closing body moves, a puncture needle on the upper part and a lower part having a drug solution passage running vertically. The communication pipe consisting of the push rod of the
A double-ended needle having a cup-shaped hub for communicating slidably with a communication means (first combination), a normal rubber stopper, and a vertically extending chemical liquid passage. A combination (second combination) with a communicating means having a cup-shaped hub for separating vertically and slidingly and airtightly attached to the inner wall of the capsule is adopted.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Toshihiro Kikuchi 3-9-3 Honjo Nishi, Kita-ku, Osaka City

Claims (4)

[Claims] 1. A drug container comprising a bottomed cylindrical container body having a reduced diameter mouth part, a rubber stopper for closing the mouth part of the container body, and a bottomed cylindrical capsule containing the drug container. An assembly, wherein the capsule has a communication means slidable up and down along the inner wall of the capsule at the open end thereof, and the open end is sealed by a cover member, and the communication means is downwardly moved. A drug container set configured such that the drug container is communicated with the outside by the communication means when moved. 2. The rubber stopper is composed of an upper closed portion and a lower communication portion, and has a chemical liquid passage that penetrates along a central axis thereof, and the chemical liquid passage of the closed portion is closed by a closing body, and the communication is established. A groove or slit is formed in the drug solution passage of the section so that the drug solution passage opens when the closing body moves, and the communication means has a drug solution passage that runs vertically and an upper puncture needle and a lower portion. 2. The drug container set according to claim 1, which comprises a communication tube formed of the push rod of (1) and a cup-shaped hub for vertically separating the communication tube and vertically and slidably attaching to the inner wall of the capsule. 3. The medicine container set according to claim 2, wherein the closing body is a spherical closing body. 4. The communication means is a double-headed needle having a vertically extending chemical solution passage, and the double-headed needle is provided with a cup-shaped hub for vertically and slidably attaching the double-headed needle to the inner wall of the capsule in a vertically airtight manner. The drug container set according to claim 1, wherein