JPH101430A - Medical lubricant agent for condom and condom treated therewith - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medial lubricant agent for a condom which is made of a biocompatible material, excellent in lubricity and application feeling and gives a suitable lubricity throughout its use and provide condoms treated with this lubricant agent. SOLUTION: This invention provides a medical lubricant agent for a condom and a condom treated therewith. The medical lubricant agent contains the following component (A) and the component (B): (A) 100 pts.wt. of the particle components comprising (A1 ) 10-85wt.% of squalene, 2-70wt.% of protein, or protein alkali metal salt, 5-70wt.% of saccharide or glycoconjugate and 0.1-20wt.% of an emulsifier and a stabilizer and (A2 ) 10-85wt.% of sequalene and 15-90wt.% of a polymer obtained from a seaweed or a plant and (B) 10-200 pts.wt. of water.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a condom lubricating agent and a condom to which the agent is attached, and more particularly, to a human body containing squalene, a partially hydrogenated product thereof, squalane or a mixture thereof. The present invention relates to a lubricating agent for condoms which is safe and has a lubricating action throughout use and has excellent performance and a condom to which the agent is attached.

[0002]

2. Description of the Related Art Conventionally, silicone oil, glycerin, petrolatum and the like have been used as lubricating agents for condoms. However, in recent years, the toxicity of silicone oil to the human body has been highlighted, and its use in the human body has been avoided. In particular, when silicone oil invades the body through a wound, it is not digested and accumulates in blood vessels and the like, which poses a problem. Further, when glycerin or vaseline is used alone, it is difficult to obtain a sufficient lubricating effect. Further, JP-A-7-267849 discloses a condom lubricant using squalane (squalane), but the amount of squalane is 5% or less, and according to Examples, most of the components are used. Are conventionally used lubricants such as sorbitol and glycerin. According to the applicant of the present invention, it is said that the use of squalane improves moisture retention and lubricity, but in the above publication, there is a fear of separation because it is not an emulsion,
Since the used amount is 5% or less, it is not considered that the advantage of squalane is fully utilized.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides a lubricating agent for condoms which overcomes the above disadvantages and has excellent properties such as maintaining lubricity during use, and a condom to which the agent is adhered. Is what you do.

[0004]

SUMMARY OF THE INVENTION One aspect of the present invention relates to a condom lubricating agent comprising the following components (A) and (B). (A) A total of 100 parts by weight of the following (A ₁ ) and (A ₂ ): (A ₁ ) 10 to 85% by weight of at least one compound selected from squalene, a partially hydrogenated product thereof and squalane, protein or protein Alkali metal salt 2-7
(A ₂ ) selected from squalene, partially hydrogenated products thereof, and squalane; a particle component comprising 0% by weight, 5 to 70% by weight of sugar or sugar complex, and a total of 0.1 to 20% by weight of emulsifier and stabilizer. 10 to 85% by weight of at least one compound
And polymers 15 to 9 obtained from seaweeds or plants
0% by weight of a particle component, and (B) 10 to 200 parts by weight of water. The second aspect of the present invention relates to a condom to which the lubricating agent according to the first aspect of the present invention is attached.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. In the lubricating agent of the present invention, at least one selected from squalene, a partially hydrogenated product thereof, and squalane (hereinafter, collectively referred to as "squalenes") is used. Squalene used in the present invention is a polyunsaturated compound represented by the following general formula [I].

[0006]

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The compound of the above general formula [I] is contained in various animal and plant raw materials such as olive oil, rice bran oil, vegetable oils such as corn oil and animal oils such as chicken, pork and general fish, and in trace amounts in the human body. These can be collected and used. However, since it is contained in a large amount in the liver oil of deep-sea sharks such as sharks, sharks, rattles, and sharks, it is advantageous to collect them from these liver oils. Synthetic squalene synthesized from isoprene or the like can also be used, but natural squalene derived from animals and plants is preferable.

The squalane used in the present invention is a completely hydrogenated squalene. Squalane has also been found in vivo, and it is said that squalane can also be regarded as a biological reaction product like squalene. When using squalane in the present invention, it is desirable to use a completely hydrogenated natural squalene. Also,
In the present invention, not only squalene and squalane but also partially hydrogenated squalene can be used. These three types of compounds may be used as an appropriate mixture. The above-mentioned hydrogenated product can be obtained by hydrogenating squalene with a metal catalyst comprising platinum, cobalt, molybdenum, nickel or a mixture thereof in a conventional manner. In particular, those having an iodine value of 3.5 g / 100 g or less have high oxidation stability and are preferred.

It is said that these squalenes are rapidly absorbed, digested and metabolized in the body.
Therefore, even if squalene enters the body through a mucous membrane, a wound, or the like, it is easily absorbed and digested, so that there is little problem of accumulation. The squalene used in the present invention is harmless to the human body because it is a substance existing in a living body. further,
As the lubricating agent of the present invention, squalenes that have undergone a phase transition by a magnetic field as in JP-A-1-263193 may be used.

In the present invention, in order to enhance the dispersibility of the above squalene in water, the squalene is formed into particles and blended. To form particles, squalene 10
85 wt%, protein 2 to 70 wt%, sugar or glycoconjugate 5-70% and an emulsifier and a total stabilizer 0.1 to 20% by weight of mixed particle components (A ₁₎ can be used. The method of blending the above components is optional, but in order to enhance the dispersibility of the squalenes and to produce fine particles, after producing an oil phase mainly containing squalene and an aqueous phase in which the protein is dissolved, It is preferable to adopt a method of blending these.

First, squalene and a small amount of an emulsifier are blended to produce an oil phase. Examples of the emulsifier include sorbitan fatty acid ester, glycerin fatty acid ester, sucrose fatty acid ester, monoglyceride, lecithin and the like. In the present invention, it is preferable to use those recognized as food additives. These emulsifiers are used in an amount of 1 to 20 parts by weight based on 100 parts by weight of squalene. If necessary, stabilizers such as xanthan gum and vegetable hardened oil can be added. Next, as the aqueous phase, a protein such as casein or casein alkali metal salt, dextrin, cyclodextrin, lactose,
Sucrose, chondroitin sulfate, carrageenan, dermatan sulfate, blended with a sugar or sugar complex such as their sodium salts, dissolved in water 1-3 times the weight of the total formulation,
Keep at 40-70 ° C. Microcrystalline cellulose as a stabilizer, an emulsifier, and the like can be added to the aqueous phase as needed. Next, the oil phase is added to the aqueous phase while stirring, and at this time, it is preferable that the oil phase is previously heated to the same temperature as the aqueous phase. After sufficiently stirring the mixture of the oil phase portion and the aqueous phase portion to disperse the contained squalene into particles, the mixture is made into finer particles under conditions such as pressure and ultrasonic waves. As a particularly preferable method, the treatment is performed using a pressurized homogenizer at a pressure of 100 to 200 kg / cm ² , a stirring rotation number of 5,000 to 10,000 rpm, and a range of 10 to 20 minutes. The diameter of the particles thus obtained is preferably about 1 to 100 μm. The particles produced by the above procedure are considered to have squalene inside and a layer of protein, sugar complex and emulsifier outside. The particles are relatively stable and do not break when dried.

As another method of forming squalene into particles, the squalene can be coated with a polymer component obtained from seaweed or a plant. That is, it is possible to use squalene acids 10 to 85 wt .-% and seaweeds or particle components consisting of polymer 15 to 90% by weight obtained from plants (A _2). Specifically, as described above, it is produced by mixing an oil phase comprising squalenes and a surfactant and an aqueous phase in which a polymer obtained from seaweed or a plant is dissolved. That is, squalene and a small amount of an emulsifier are first blended to produce an oil phase. The type and amount of the emulsifier used are the same as described above. If necessary, stabilizers such as xanthan gum, vegetable hardened oil, and beeswax can be added. The temperature at this time is preferably from 60 ° C to 80 ° C. Next, as an aqueous phase, a polymer obtained from a seaweed or a plant such as gum arabic, carrageenan, alginate, carboxymethylcellulose, etc. is dissolved in water. If necessary, microcrystalline cellulose may be added as a stabilizer. Next, the oil phase is added to the aqueous phase while stirring. The addition method is exactly the same as described above. Also in this case, the diameter of the particles is preferably about 1 to 100 μm. In the particles obtained here, the outer layer of the particles is composed of a polymer obtained from seaweed or a plant, and it is considered that squalene exists inside the particles.

By using the lubricating agent of the present invention in which the particles are dispersed as described above, the lubricating agent can maintain the lubricating property for a longer period of time than an emulsion simply comprising a surfactant and squalene. The particle dispersion obtained as described above, if the concentration is appropriate and has sufficient lubricity, can be used as it is as a condom lubricant, but in order to adjust the concentration, After taking out the dried particles as a powder, an appropriate amount of water may be added. As a method for drying, freeze drying, spray drying and the like are used.

The lubricating agent of the present invention comprises 10 to 200 parts by weight of water, preferably 50 to 150 parts by weight, based on 100 parts by weight of the total of the powdered particle components (A ₁ ) and (A ₂ ).
It is obtained by blending parts by weight. Here, the mixing ratio of (A ₁ ) and (A ₂ ) can be appropriately selected from the range of 0 to 100% by weight, respectively. If the water content is less than 10 parts by weight, the particles may not be dispersed. If the water content is more than 200 parts by weight, a sufficient lubricating effect may not be exhibited, and the usability may be reduced. The preferred viscosity of the lubricating agent of the present invention ranges from 100 to 1,000 cP at 25 ° C.

The lubricating agent of the present invention includes, without departing from the spirit of the present invention, menthol; palm oil; olive oil; sesame oil; horse oil; jojoba oil; honey;
Eicosapentaenoic acid; Docosahexaenoic acid; Cholesterol; Cholesterol fatty acid ester; Lysophospholipids; Rubbers such as isoprene rubber and natural rubber; Vitamin E; Vaseline; viscosity modifiers such as glycerin; antioxidants; extenders; antimicrobial agents such as chitin and chitosan; preservatives; spermicides; Any of water-soluble and oil-soluble additives can be used. In addition, the amount of the squalene used can generally be added up to 1/2 of the weight of the squalene in the lubricating agent, but it is necessary to pay sufficient attention so as not to cause separation. In addition, fine powders such as polyethylene, polystyrene, polymethyl methacrylate, polyvinyl acetate, and copolymers of monomers constituting these can be blended with the lubricating agent of the present invention.

A second aspect of the present invention is a condom to which the above-mentioned lubricating agent is attached. As a target condom,
Examples include condoms made of natural rubber such as latex, condoms made of synthetic rubber such as SBR latex, condoms made of collagen, and condoms made of plastic such as polyurethane. These condoms
The surface of the condom may be treated with radiation, ozone, plasma, electron beam, or the like, or a condom surface may be added with a polar monomer to improve the retention of a lubricating agent.

The method of attaching the lubricating agent to the condom is arbitrary. The lubricating agent of the present invention may be sprayed on a condom, or the condom may be immersed in the lubricating agent. Or you may apply with a brush etc. Usually, it is desirable to attach the lubricating agent of the present invention to both sides of a condom. It is preferable that the lubricating agent of the present invention be uniformly adhered to the whole in an amount of 0.05 to 20 cc per condom. Examples of specific adhesion methods include, for example, dipping a condom mold into a polyisoprene solution, crosslinking and drying to form a condom, and then spraying the lubricating agent of the present invention, various methods such as dropping and dipping. And a method in which a formed condom is wound up in a disk shape on a mold, and a lubricating agent is dropped on the condom and penetrated into the whole by capillary action.

[0018]

The present invention will be described below with reference to examples. <Production Example of Lubricant> 200 parts of water was kept at a temperature of 65 ° C., and the components of the aqueous phase shown in Table 1 were dissolved therein.
Next, the component mixture in the oil phase portion shown in the same table was added little by little to produce an emulsion. Thereafter, the emulsion was made into finer particles at a pressure of 150 kg / cm ² using a pressure homogenizer, and dried by a spray dryer to obtain a powdery composition (powder A to D).

[0019]

[Table 1]

<Manufacture of Condom> A condom made of natural rubber latex and a condom made of polyether-based urethane were manufactured, and the lubricating agent described in each example was applied.

<Method of judging use results> The results of the following three-level evaluations of the feeling of use are tabulated for use by 25 male monitors. For comparison, a conventional product in which silicone oil was applied to the same condom as in the example was used. A: Usability, wearing feeling, etc. are better than conventional products B: Usability, wearing feeling, etc. do not change compared to conventional products (including unknown) C: Usability, wearing feeling, etc. are better with conventional products

<Example 1 and Comparative Example 1> 1 g of the composition shown in Table 2 was picked up and rubbed with both hands, and it was examined which of them had longer lubricity. This was done and evaluated by 10 testers. The results are as follows. 8 persons who answered that Example 1 was long 2 persons who answered that Comparative Example 1 was long In addition, any of the compositions was unexpectedly used for purposes other than the experiment, such as the appearance of gloss on the hands of the testers. Was observed. This also indicates that squalenes are excellent materials that come into contact with the body. Further, the lubricating agent of Example 1 is a slightly soft creamy substance, and a condom is manufactured using the lubricating agent according to the method described above.
The use result was determined. Table 3 shows the results.

<Examples 2 to 4> The lubricating agents having the compositions shown in Table 2 are slightly soft cream-like materials, and condoms are manufactured and used in the same manner as in Example 1 by using them. The result was determined. Table 3 shows the results.

[0024]

[Table 2]

[0025]

[Table 3]

<Examples 5 to 11> In addition to powder and purified water, several components were added to produce lubricating agents. The composition is shown in Table 4. The stability and lubricity of the lubricating agent were sufficient for use.

[0027]

[Table 4]

[0028]

According to the present invention, a lubricating agent for condoms containing a large amount of biocompatible squalene, which is safe, has an excellent lubricating effect and has a moisturizing effect, and a condom using the same. Can be provided. The lubricating agent of the present invention can maintain lubricity throughout the period of use. It is considered that squalene is released only when particles dispersed in water are destroyed due to friction and impact during use, body temperature, contact with substances in the body, and the like. In addition, since squalene is present in the particles, it is expected that the squalene is hardly modified by oxidation or the like. Furthermore, since the lubricating agent of the present invention contains water, it has good compatibility with body fluids and the like, has no uncomfortable feeling, and can contain various water-soluble additives. Further, when an oil-based lubricant is used, depending on the combination of the condom material and the lubricant, the condom may be dissolved or swelled to lower the mechanical strength. There is little such concern. In addition, squalene is said to be a lubricating agent for condoms because it is said that it has a cell activating effect, an anti-inflammatory effect, or an ability to activate male and female hormones.

Claims (2)

[Claims] 1. A condom lubricating agent comprising the following components (A) and (B): (A) a total of 100 parts by weight of the following (A ₁ ) and (A ₂ ) (A ₁ ) squalene; 10 to 85% by weight of at least one compound selected from partially hydrogenated products and squalane, protein or protein alkali metal salt 2 to 7
0% by weight, sugar or particulate components consisting of a total of 0.1 to 20 wt% of a glycoconjugate 5-70% and emulsifiers and stabilizers, (A ₂₎ squalene, selected from the partial hydrogenation product and squalane At least one compound 10-8
5% by weight and a particle component comprising 15 to 90% by weight of a polymer obtained from a seaweed or a plant, and (B) 10 to 200 parts by weight of water. 2. A condom to which the lubricating agent according to claim 1 is adhered.