JPH09619A - Method for cleaning hemodialysis system - Google Patents

Abstract

PURPOSE: To clean a hemodialysis system with an odorless washing liquid by using acidic ion water which is provided with a pH in a specific range, oxidation-reduction potential at or above a specific value, effective chlorine concentration in a specific range and dissolved oxygen with a specific or higher ppm. CONSTITUTION: After a regular hemodialysis system is used on a patient, it is cleaned with acidic ion water which is 0-6 in pH, 500mV or above in oxidation-reduction potential, 0.1-1,000ppm in effective chlorine concentration and 0.1ppm or above in dissolved oxygen. In other words, it is cleaned for 20 minutes by circulating the acidic ion water from the liquid tank 1 to a dialysis liquid feeder 2, hose 3, patient monitor 4, hose 3, dialysis effluent hose 6, monitor 4, and effluent hose 6. Consequently, the hemodialysis system is effectively sterilized by the washing liquid that is odorless and easy-to-handle.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for cleaning a hemodialysis system and its cleaning solution. More specifically, the present invention relates to a method for cleaning a hemodialysis system, which is useful for environmental protection and a hemodialysis system cleaning solution having a low odor.

[0002]

2. Description of the Related Art Hemodialysis systems are used to remove uremic toxins and the like in patients with renal failure, that is, to perform hemodialysis. After the hemodialysis is finished, the hemodialysis system is washed to prevent the growth of microorganisms and viruses.
Conventionally, an aqueous solution of sodium hypochlorite has been used for this cleaning.

However, since the sodium hypochlorite aqueous solution has a strong odor, it is difficult to handle. Further, since the sodium hypochlorite aqueous solution is a strong oxidizing agent, discarding a large amount of it as a waste liquid is problematic in terms of environmental protection. Therefore, it is necessary to chemically process and dispose with a neutralizer or the like. As a result, there is a problem that it takes time to clean up. Therefore, there has been a demand for the development of an alternative cleaning solution.

[0004]

SUMMARY OF THE INVENTION An object of the present invention is to provide a method for cleaning a hemodialysis system with a cleaning solution that does not have an offensive odor.
And, it relates to something useful for environmental protection.

[0005]

DISCLOSURE OF THE INVENTION In order to solve the above-mentioned method for cleaning a hemodialysis system, the present inventors have made diligent efforts to develop a new method that replaces the method using an aqueous solution of sodium hypochlorite. As a result, it was surprisingly found that washing the hemodialysis system with acidic ionized water achieves its purpose. The present invention has been achieved based on such findings.

The present invention is a method of cleaning a hemodialysis system with acidic ionized water. The cleaning method of the present invention is achieved by using a hemodialysis system cleaning liquid composed of acidic ionized water.

The hemodialysis system is a device for sending blood to a dialyzer to remove waste products (urinary toxic substances) and excess water in the blood. In a dialysis system, a dialyzer replaces the human kidney. Schematic diagrams of the dialyzer and the dialysis system are shown in FIGS. 1 and 2, respectively. In addition,
FIG. 2 is a modification of "Handling and Maintenance of Extracorporeal Circulation Equipment by Kazuo Ota et al., Artificial Kidney, Knowledge of ME and Equipment Safety, ME Technical Workshop Executive Committee Training, Nankodo, pp. 161-171".

As shown in FIG. 1, when the patient's blood is pumped into the dialyzer, it contacts the dialysate through the semipermeable membrane. At this time, waste products in the blood are sent to the dialysate,
It becomes waste-removed blood and is sent from the dialyzer into the patient's body. On the other hand, in this case, as shown in FIG. 2, the dialysate is sent from the tank to the dialyzer through the dialysate supply device, the dialysate hose, and the patient monitoring device, and becomes the dialysate waste liquid from the dialyzer. Drain as waste through the waste hose and patient monitor.

The dialysate contains sodium ions, potassium ions, calcium ions, magnesium ions, chloride ions, acetic acid, glucose and the like. In addition to the components contained in the dialysate, the dialysate waste fluid contains urinary toxic substances derived from patient blood. Urinary toxic substances include urea nitrogen, creatinine, and uric acid.

As a result, if the dialysate supply device, the dialysate hose, the dialysate waste hose, and the patient monitor are left unattended, microorganisms are likely to propagate. Therefore, it is necessary to treat these, especially the dialysis waste liquid hose and the patient monitoring device, with a cleaning liquid.

The present invention is characterized in that acidic ionic water is used as the cleaning liquid. In the present invention, acidic ionized water means acidic electrolyzed water produced on the anode side by electrolyzing water by using a diaphragm and adding a small amount of electrolyte. In this case, it is preferable to use an ion exchange membrane as the diaphragm. This is because acidic ionized water having a high redox potential can be produced, and as a result, ionized water having a strong bactericidal power can be produced.

The electrolyte preferably contains chlorides such as sodium chloride and magnesium chloride, and more preferably sodium chloride.

Such acidic ionized water can be manufactured by Oasis Bio (trade name) manufactured by Asahi Glass Engineering.

In the present invention, the pH of acidic ionized water
Is preferably 6.9 or less, more preferably 0 to 6, still more preferably 0.5 to 5, and particularly preferably 1.8 to
3.0. If the pH is too low, it takes time to produce acidic ionized water, which makes it difficult to produce. If the pH is too high, the bactericidal activity is affected.

The redox potential of the acidic ionized water of the present invention is
Preferably 500 mV or more, more preferably 600 mV
The above is particularly preferable, and it is 800 mV or more. If the redox potential is too low, the disinfecting power is weak. The upper limit of the redox potential depends on the production apparatus of the acidic ionized water, the concentration of the electrolyte and the like, but if it is too high, it is difficult to produce the acidic ionized water.

In the acidic ionized water of the present invention, the effective chlorine concentration is usually 0.1 to 1000 ppm, preferably 1 to 100.
ppm, more preferably 10 to 50 ppm. In the acidic ionized water of the present invention, the dissolved oxygen is usually 0.1 ppm or more, preferably 1 ppm or more, more preferably 10 pp.
Contains m or more. The upper limit depends on the production apparatus of acidic ionized water and the like. That is, the hemodialysis system cleaning solution of the present invention,
From the viewpoint of sterilizing power and easiness of production, pH is 0 to 6, redox potential is 500 mV or more, and effective chlorine concentration is 0.1 to 10.
A cleaning solution having a concentration of 00 ppm and a dissolved oxygen content of 0.1 ppm or more is preferable. Furthermore, pH is 1.8 to 3.0, redox potential is 800 mV or higher, and effective chlorine concentration is 10 to 5
It is particularly preferable that the strongly acidic ionized water has 0 ppm and dissolved oxygen is 10 ppm or more.

In the method of washing the hemodialysis system with acidic ionized water, in the case of washing with an aqueous solution of sodium hypochlorite, the stock solution is usually used after being diluted with a large amount of water in the apparatus. However, the acidic ionized water of the present invention can be used as it is without diluting the stock solution with water. If it is diluted too much with water, the disinfecting power may decrease.

As a method for washing the stock solution without diluting it with water, after the patient has dialyzed blood with a hemodialysis system, acidic ionized water is passed through the circuit used for the stock solution tank B in the solution tank shown in FIG. This can be done by connecting to a chemical pump inside the device. The dialysate waste hose can be washed by turning the discharge flow rate knob of the chemical pump to adjust the injection amount of the chemical. After washing, it is better to wash with water for 2 hours or more. It should be noted that the personal hemodialysis system can be cleaned in a similar manner. Cleaning the dialysis system by this method is sufficient for disinfection and is effective for environmental protection.

[0019]

In the present invention, acidic ionized water is considered to be effective for cleaning the hemodialysis system because it has a high redox potential and contains active oxygen. Also, when the acidic ionized water contains chlorine, it is considered that active oxygen and chlorine are generated.
It is estimated that this is also particularly effective for disinfection. Further, the acidic ionized water of the present invention, when contacted with light, soil, organic matter,
It is thought that it will be effective for environmental protection because it will quickly return to normal water by decomposition.

[0020]

[Example] As the acidic ionized water, strong acidic ionized water manufactured by Oasis Bio (trade name) manufactured by Asahi Glass Engineering Co., Ltd. was used. This strongly acidic ionized water has a pH of 2.7 or less,
Redox potential 1100 mV or more, available chlorine 30-40p
It has characteristics of pm and dissolved oxygen of 20 ppm or more.

First, a patient was hemodialyzed by a normal hemodialysis system. Then, the acidic ionized water of the present invention was added to FIG.
Into the stock solution tank B in the solution tank shown in FIG. Then
The dialyzer is removed and the dialysate hose 3 and the dialysate waste hose 6 are connected to supply acidic ionized water from the liquid tank 1 to the dialysate supply device 2, the dialysate hose 3, the patient monitoring device 4, the dialysate hose 3, The dialysis waste liquid hose 6, the patient monitor 4, and then the dialysis waste liquid hose 6 were washed for 20 minutes. The waste liquid after washing is taken out, and three types of standard strains [E. coli (Esher
ichia coli), Staphylococcus aureus (staph)
ylococcus aureus), and Pseudomonas aeruginosa (P
Seudononas aeruginosa)] was added to the cell suspension at 10 ⁶ cfu / ml, and the growth of the cells was observed. As a result, a bactericidal effect was recognized within at least 15 seconds.

[0022]

The acidic ionized water of the present invention has little odor and is easy to handle. In addition, the hemodialysis system can be washed by using the undiluted solution as it is without diluting it with water. In addition, it has a strong bactericidal effect. Moreover, since it is easy to return to normal water, it is useful for environmental protection.
Therefore, the method of the present invention greatly contributes to the medical field and environment.

[Brief description of drawings]

FIG. 1 shows a schematic diagram of a dialyzer in a hemodialysis system.

[Explanation of symbols]

 1 dialysate supply device 2 dialysate hose 3 dialysate waste hose 4 dialysate flow 5 dialysate waste flow 6 dialyzer 7 semipermeable membrane 8 patient blood flow 9 waste product removal blood flow

FIG. 2 shows a schematic diagram of a hemodialysis system. 1 liquid tank (consisting of chemical liquid tank, A stock solution tank and B stock solution tank) 2 dialysate supply device 3 dialysate hose 4 patient monitor 5 dialyzer 6 dialysate waste hose 7 blood pump 8 patient's hand 9 patient blood flow 10 Waste removal blood

Claims (3)

[Claims] 1. A method of cleaning a hemodialysis system with acidic ionized water. 2. A hemodialysis system cleaning liquid comprising acidic ionized water. 3. The pH is 0 to 6, and the redox potential is 500 m.
A hemodialysis system cleaning liquid having V or more, an effective chlorine concentration of 0.1 to 1000 ppm, and dissolved oxygen of 0.1 ppm or more.