JPH09504012A - シクロスポリンA及びα−トコフェロールを含有する医薬組成物 - Google Patents
シクロスポリンA及びα−トコフェロールを含有する医薬組成物Info
- Publication number
- JPH09504012A JPH09504012A JP7511237A JP51123795A JPH09504012A JP H09504012 A JPH09504012 A JP H09504012A JP 7511237 A JP7511237 A JP 7511237A JP 51123795 A JP51123795 A JP 51123795A JP H09504012 A JPH09504012 A JP H09504012A
- Authority
- JP
- Japan
- Prior art keywords
- tocopherol
- cyclosporin
- cyclosporine
- pharmaceutical preparation
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.シクロスポリンAおよびα−トコフェロールまたはその誘導体から構成され るかまたはそれらを含有する医薬製剤。 2.α−トコフェロール誘導体として、α−トコフェロールスクシナート、α− トコフェロールアセタートまたはD−α−トコフェロールポリエチレングリコー ル−1000−スクシナートであることを特徴とする請求項1に記載の医薬製剤 。 3.植物油中のα−トコフェロール濃縮物の形のα−トコフェロールを含有する ことを特徴とする請求項1に記載の医薬製剤。 4.シクロスポリンAと植物油中のα−トコフェロール濃縮物の混合により得ら れる、請求項3に記載の医薬製剤。 5.シクロスポリンAに対して900%以下のα−トコフェロールまたはその誘 導体を含有することを特徴とする、前記請求項のうちの1項に記載の医薬製剤。 6.組成物に対してシクロスポリンA≧10%を含有することを特徴とする前記 請求項のうちの1項に記載の医薬製剤。 7.処理助剤として特に20%以下の量のエタノールまたはイソプロパノールを 含有することを特徴とする前記請求項のうちの1項に記載の医薬製剤。 8.乳化剤を含有することを特徴とする前記請求項のう ちの1項に記載の医薬製剤。 9.増粘剤を含有することを特徴とする請求項8に記載の医薬製剤。 10.非経口用注入濃縮物に慣用される生理学的に許容される助剤を含む形であ る前記請求項のうちの1項に記載の医薬製剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4336163 | 1993-10-22 | ||
DE4336163.3 | 1993-10-22 | ||
PCT/EP1994/003274 WO1995011039A1 (de) | 1993-10-22 | 1994-09-30 | Pharmazeutische zusammensetzung mit cyclosporin a und alpha-tocopherol |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09504012A true JPH09504012A (ja) | 1997-04-22 |
JP3644543B2 JP3644543B2 (ja) | 2005-04-27 |
Family
ID=6500831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51123795A Expired - Lifetime JP3644543B2 (ja) | 1993-10-22 | 1994-09-30 | シクロスポリンA及びα−トコフェロールを含有する医薬組成物 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0724452B1 (ja) |
JP (1) | JP3644543B2 (ja) |
DE (2) | DE10199039I2 (ja) |
ES (1) | ES2148345T3 (ja) |
WO (1) | WO1995011039A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013544802A (ja) * | 2010-10-29 | 2013-12-19 | バイオコピア リミテッド | 炎症性疾患 |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
EP0786986B1 (en) | 1994-10-26 | 2002-03-20 | Novartis AG | Use of an unsaturated fatty alcohol |
GB2327610B (en) * | 1994-11-04 | 1999-06-02 | Novartis Ag | Macrolide compositions |
HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
DE19521974A1 (de) * | 1995-06-16 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Pharmazeutische Zubereitung mit Cyclosporin A |
US6696413B2 (en) * | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
US5798333A (en) * | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6727280B2 (en) | 1997-01-07 | 2004-04-27 | Sonus Pharmaceuticals, Inc. | Method for treating colorectal carcinoma using a taxane/tocopherol formulation |
US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
JP4761093B2 (ja) | 1997-12-10 | 2011-08-31 | シクロスポリン セラポイティクス リミテッド | オメガ−3脂肪酸油を含む医薬組成物 |
IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
GB9817650D0 (en) * | 1998-08-14 | 1998-10-07 | Danbiosyst Uk | Oral formulation |
WO2001022937A1 (en) * | 1999-09-27 | 2001-04-05 | Sonus Pharmaceuticals, Inc. | Compositions of tocol-soluble therapeutics |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
WO2002026208A2 (en) * | 2000-09-27 | 2002-04-04 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
KR100982466B1 (ko) | 2001-10-19 | 2010-09-16 | 이소테크니카 인코포레이티드 | 시클로스포린 유사체의 합성 |
US6858227B1 (en) | 2001-11-21 | 2005-02-22 | Sonus Pharmaceuticals, Inc. | Vitamin E conjugates |
US7101576B2 (en) | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
EP1510206A1 (en) * | 2003-08-29 | 2005-03-02 | Novagali Pharma SA | Self-nanoemulsifying oily formulation for the administration of poorly water-soluble drugs |
BRPI0415858A (pt) | 2003-10-29 | 2007-01-09 | Sonus Pharma Inc | compostos de medicamentos terapêuticos modificados por tocoferol |
AU2008310956B2 (en) | 2007-10-08 | 2014-08-07 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors |
US9737500B2 (en) | 2010-10-29 | 2017-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
US10695432B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
-
1994
- 1994-09-30 ES ES94928852T patent/ES2148345T3/es not_active Expired - Lifetime
- 1994-09-30 JP JP51123795A patent/JP3644543B2/ja not_active Expired - Lifetime
- 1994-09-30 WO PCT/EP1994/003274 patent/WO1995011039A1/de active IP Right Grant
- 1994-09-30 DE DE10199039C patent/DE10199039I2/de active Active
- 1994-09-30 DE DE59409377T patent/DE59409377D1/de not_active Expired - Lifetime
- 1994-09-30 EP EP94928852A patent/EP0724452B1/de not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013544802A (ja) * | 2010-10-29 | 2013-12-19 | バイオコピア リミテッド | 炎症性疾患 |
Also Published As
Publication number | Publication date |
---|---|
EP0724452A1 (de) | 1996-08-07 |
JP3644543B2 (ja) | 2005-04-27 |
EP0724452B1 (de) | 2000-05-24 |
WO1995011039A1 (de) | 1995-04-27 |
DE59409377D1 (de) | 2000-06-29 |
DE10199039I1 (de) | 2001-11-22 |
ES2148345T3 (es) | 2000-10-16 |
DE10199039I2 (de) | 2008-08-07 |
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