JPH09500446A - 液状放射性廃棄物からの放射性標識された生物学的分子の除去方法 - Google Patents
液状放射性廃棄物からの放射性標識された生物学的分子の除去方法Info
- Publication number
- JPH09500446A JPH09500446A JP7502104A JP50210495A JPH09500446A JP H09500446 A JPH09500446 A JP H09500446A JP 7502104 A JP7502104 A JP 7502104A JP 50210495 A JP50210495 A JP 50210495A JP H09500446 A JPH09500446 A JP H09500446A
- Authority
- JP
- Japan
- Prior art keywords
- solid phase
- binder
- magnetizable
- radioactive waste
- radiolabeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000010857 liquid radioactive waste Substances 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims description 95
- 239000011230 binding agent Substances 0.000 claims abstract description 121
- 239000007790 solid phase Substances 0.000 claims abstract description 108
- 239000003463 adsorbent Substances 0.000 claims description 49
- 239000002245 particle Substances 0.000 claims description 40
- 239000003610 charcoal Substances 0.000 claims description 35
- 230000000984 immunochemical effect Effects 0.000 claims description 34
- 239000002901 radioactive waste Substances 0.000 claims description 28
- 229920000642 polymer Polymers 0.000 claims description 25
- 239000007791 liquid phase Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 229920002401 polyacrylamide Polymers 0.000 claims description 12
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 9
- 229940034208 thyroxine Drugs 0.000 claims description 9
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 8
- 239000011324 bead Substances 0.000 claims description 8
- 235000019152 folic acid Nutrition 0.000 claims description 8
- 239000011724 folic acid Substances 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 229940014144 folate Drugs 0.000 claims description 7
- 239000011715 vitamin B12 Substances 0.000 claims description 6
- 241001494479 Pecora Species 0.000 claims description 5
- 229930003779 Vitamin B12 Natural products 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 235000019163 vitamin B12 Nutrition 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000011491 glass wool Substances 0.000 claims description 4
- 230000005291 magnetic effect Effects 0.000 claims description 3
- 239000002952 polymeric resin Substances 0.000 claims description 3
- 229920003002 synthetic resin Polymers 0.000 claims description 3
- 239000000454 talc Substances 0.000 claims description 3
- 229910052623 talc Inorganic materials 0.000 claims description 3
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 2
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 1
- 229940045999 vitamin b 12 Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 62
- 239000000126 substance Substances 0.000 description 19
- 230000002285 radioactive effect Effects 0.000 description 18
- 239000000427 antigen Substances 0.000 description 16
- 238000003127 radioimmunoassay Methods 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 239000007788 liquid Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- 239000011347 resin Substances 0.000 description 12
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 11
- 238000000926 separation method Methods 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 238000003556 assay Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 239000006193 liquid solution Substances 0.000 description 7
- 239000002699 waste material Substances 0.000 description 7
- 241000473945 Theria <moth genus> Species 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 238000003018 immunoassay Methods 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 239000005373 porous glass Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000012857 radioactive material Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- -1 polyacrolein Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 231100000167 toxic agent Toxicity 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 101710120037 Toxin CcdB Proteins 0.000 description 2
- 239000002156 adsorbate Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000011005 laboratory method Methods 0.000 description 2
- 239000010808 liquid waste Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- CXENHBSYCFFKJS-OXYODPPFSA-N (Z,E)-alpha-farnesene Chemical compound CC(C)=CCC\C(C)=C\C\C=C(\C)C=C CXENHBSYCFFKJS-OXYODPPFSA-N 0.000 description 1
- 235000007754 Achillea millefolium Nutrition 0.000 description 1
- 240000000073 Achillea millefolium Species 0.000 description 1
- 101000689231 Aeromonas salmonicida S-layer protein Proteins 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241000252095 Congridae Species 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000015731 Peptide Hormones Human genes 0.000 description 1
- 108010038988 Peptide Hormones Proteins 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 101000748795 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) Cytochrome c oxidase polypeptide I+III Proteins 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000005260 alpha ray Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000010936 aqueous wash Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000005250 beta ray Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000002925 low-level radioactive waste Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 229910000480 nickel oxide Inorganic materials 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
- AJCDFVKYMIUXCR-UHFFFAOYSA-N oxobarium;oxo(oxoferriooxy)iron Chemical compound [Ba]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O AJCDFVKYMIUXCR-UHFFFAOYSA-N 0.000 description 1
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 230000000693 radiobiological effect Effects 0.000 description 1
- 238000011363 radioimmunotherapy Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F9/00—Treating radioactively contaminated material; Decontamination arrangements therefor
- G21F9/04—Treating liquids
- G21F9/06—Processing
- G21F9/12—Processing by absorption; by adsorption; by ion-exchange
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7303993A | 1993-06-08 | 1993-06-08 | |
| US08/073,039 | 1993-06-08 | ||
| US08/255,229 | 1994-06-07 | ||
| US08/255,229 US5564104A (en) | 1993-06-08 | 1994-06-07 | Methods of removing radioactively labled biological molecules from liquid radioactive waste |
| PCT/US1994/006521 WO1994029880A1 (en) | 1993-06-08 | 1994-06-08 | Methods of removing radioactively labeled biological molecules from liquid radioactive waste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09500446A true JPH09500446A (ja) | 1997-01-14 |
Family
ID=26754056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7502104A Pending JPH09500446A (ja) | 1993-06-08 | 1994-06-08 | 液状放射性廃棄物からの放射性標識された生物学的分子の除去方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5564104A (enExample) |
| EP (2) | EP0788651A1 (enExample) |
| JP (1) | JPH09500446A (enExample) |
| AU (1) | AU7058594A (enExample) |
| CA (1) | CA2164332A1 (enExample) |
| WO (1) | WO1994029880A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005528627A (ja) * | 2002-06-01 | 2005-09-22 | バイオダイナミックス リサーチ リミテッド | 新しい回収プロセス |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103127A (en) | 1993-06-08 | 2000-08-15 | Cortex Biochem, Inc. | Methods for removing hazardous organic molecules from liquid waste |
| US5827497A (en) * | 1996-08-14 | 1998-10-27 | Mayo Foundation For Medical Education And Research | Charcoal-radionuclide agents for measurement of gastrointestinal transit |
| US6199152B1 (en) | 1996-08-22 | 2001-03-06 | Transmeta Corporation | Translated memory protection apparatus for an advanced microprocessor |
| US6368866B1 (en) | 1998-08-03 | 2002-04-09 | Reference Diagnostics, Inc. | Rapid separation assay for total iron binding capacity |
| IES990347A2 (en) * | 1999-04-26 | 2000-10-04 | Suren Aghajanian | De-staining Composition and Apparatus |
| KR100330040B1 (ko) * | 1999-04-30 | 2002-03-27 | 정신검 | 액체 방사물 여과장치 및 그 방법 |
| US6414136B1 (en) | 1999-10-06 | 2002-07-02 | Prolinx, Inc. | Removal of dye-labeled dideoxy terminators from DNA sequencing reactions |
| US6968469B1 (en) | 2000-06-16 | 2005-11-22 | Transmeta Corporation | System and method for preserving internal processor context when the processor is powered down and restoring the internal processor context when processor is restored |
| US6855499B1 (en) | 2001-02-16 | 2005-02-15 | Cortex Biochem, Inc. | Magnetic isolation and purification of nucleic acids |
| US20050032243A1 (en) * | 2001-07-25 | 2005-02-10 | Pollack Gary M. | Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption |
| US20040137449A1 (en) * | 2001-10-05 | 2004-07-15 | Nargessi R D | Magnetic isolation and purification of nucleic acids |
| ES2321492T3 (es) * | 2001-11-06 | 2009-06-08 | Promega Corporation | Aislamiento y purificacion de acidos nucleicos. |
| US6972095B1 (en) | 2003-05-07 | 2005-12-06 | Electric Power Research Institute | Magnetic molecules: a process utilizing functionalized magnetic ferritins for the selective removal of contaminants from solution by magnetic filtration |
| US20050158812A1 (en) * | 2004-01-16 | 2005-07-21 | Gomez Elizabeth A. | Kits and methods for autoantibody detection |
| JP3927580B2 (ja) * | 2004-12-09 | 2007-06-13 | 住友ベークライト株式会社 | Dna鎖伸長方法、dna鎖増幅方法およびdna鎖伸長用マイクロアレイ |
| US8822670B2 (en) * | 2005-08-19 | 2014-09-02 | Sumitomo Bakelite Company, Ltd. | Method of synthesizing cDNA and method of synthesizing RNA chains, and nucleotide-immobilized carrier |
| US8097164B2 (en) * | 2007-11-08 | 2012-01-17 | Electric Power Research Institute, Inc. | Process for preparing magnetic particles for selectively removing contaminants from solution |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US9240253B2 (en) * | 2010-04-07 | 2016-01-19 | Ge-Hitachi Nuclear Energy Americas Llc | Column geometry to maximize elution efficiencies for molybdenum-99 |
| CN115109939A (zh) * | 2022-07-11 | 2022-09-27 | 上海交通大学四川研究院 | 一种低放射性本底金属材料的冶炼方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2752309A (en) * | 1952-04-30 | 1956-06-26 | Ardath H Emmons | Process for water decontamination |
| FR1573936A (enExample) * | 1967-02-16 | 1969-07-11 | ||
| US4992377B1 (en) * | 1967-02-16 | 1996-10-15 | Saxholm As | Article for carrying out biological or chemical procedures containing magnetically responsive material |
| US4371624A (en) * | 1976-08-23 | 1983-02-01 | Rolf Saxholm | Apparatus and testing reactions |
| US4213825A (en) * | 1976-08-23 | 1980-07-22 | Rolf Saxholm | Apparatus for testing reactions |
| US3981776A (en) * | 1967-02-16 | 1976-09-21 | Rolf Saxholm | Magnetically responsive, biologically active substance and associated methods and apparatus |
| US3985608A (en) * | 1969-05-03 | 1976-10-12 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological, clinical-chemical and similar laboratory work |
| NO124603B (enExample) * | 1969-05-03 | 1972-05-08 | Rolf Saxholm | |
| US4140582A (en) * | 1969-05-03 | 1979-02-20 | Rolf Saxholm | Supporting element for use in microbiological, serological, immunological clinical-chemical and similar laboratory work |
| US4033868A (en) * | 1970-07-20 | 1977-07-05 | Licentia Patent-Verwaltungs-G.M.B.H. | Method and apparatus for processing contaminated wash water |
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| US3986479A (en) * | 1973-10-11 | 1976-10-19 | Colgate-Palmolive Company | Pre-moistened towelette dispenser |
| US4020003A (en) * | 1976-02-24 | 1977-04-26 | The United States Of America As Represented By The United States Energy Research And Development Administration | Fixation of tritium in a highly stable polymer form |
| US4104026A (en) * | 1976-03-12 | 1978-08-01 | University Of Virginia | Immunoassay separation technique |
| US4657868A (en) * | 1980-01-15 | 1987-04-14 | Rolf Saxholm | Apparatus for testing reactions |
| US4695392A (en) * | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| JPS59231493A (ja) * | 1983-06-15 | 1984-12-26 | 住友金属鉱山株式会社 | 低レベル放射性廃液の処理方法 |
| US4643981A (en) * | 1983-11-09 | 1987-02-17 | Akzo N.V. | Pressure filtration system |
| US4687581A (en) * | 1984-01-30 | 1987-08-18 | Pedro B. Macedo | Method of separating and purifying cations by ion exchange with regenerable porous glass |
| US4645625A (en) * | 1984-11-26 | 1987-02-24 | Ionics, Incorporated | Decontamination of a radioactive waste liquid by electrodialysis |
| US4800042A (en) * | 1985-01-22 | 1989-01-24 | Jgc Corporation | Radioactive waste water treatment |
| US4853130A (en) * | 1985-12-20 | 1989-08-01 | Epicor Incorporated | Method for purifying liquids |
| US4902665A (en) * | 1986-04-07 | 1990-02-20 | Iso-Clear Systems Corporation | Removal of heavy metals and heavy metal radioactive isotopes from liquids |
| US4780239A (en) * | 1986-05-22 | 1988-10-25 | Westinghouse Electric Corp. | Ion exchange resin for immobilizing radioactive waste |
| GB8719045D0 (en) * | 1987-08-12 | 1987-10-07 | Atomic Energy Authority Uk | Liquid treatment process |
| US4876232A (en) * | 1987-09-28 | 1989-10-24 | Pedro B. Macedo | Supported heteropolycyclic compounds in the separation and removal of late transition metals |
| US5024767A (en) * | 1988-04-04 | 1991-06-18 | Toray Industries, Inc. | Method for purifying liquids |
| DD293219A5 (de) * | 1988-12-14 | 1991-08-22 | ������@������������k�� | Verfahren zum aufbereiten von borverbindungen und radionuklide enthaltendem abwasser |
| US5122268A (en) * | 1989-08-11 | 1992-06-16 | Westinghouse Electric Corp. | Apparatus for waste disposal of radioactive hazardous waste |
-
1994
- 1994-06-07 US US08/255,229 patent/US5564104A/en not_active Expired - Lifetime
- 1994-06-08 WO PCT/US1994/006521 patent/WO1994029880A1/en not_active Ceased
- 1994-06-08 JP JP7502104A patent/JPH09500446A/ja active Pending
- 1994-06-08 CA CA002164332A patent/CA2164332A1/en not_active Abandoned
- 1994-06-08 EP EP94919432A patent/EP0788651A1/en not_active Withdrawn
- 1994-06-08 AU AU70585/94A patent/AU7058594A/en not_active Abandoned
- 1994-06-08 EP EP98122702A patent/EP0932163A3/en not_active Withdrawn
-
1996
- 1996-05-31 US US08/657,748 patent/US5790964A/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005528627A (ja) * | 2002-06-01 | 2005-09-22 | バイオダイナミックス リサーチ リミテッド | 新しい回収プロセス |
| US7807040B2 (en) | 2002-06-01 | 2010-10-05 | Biodynamics Research Limited | Recovery process |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0788651A4 (enExample) | 1997-08-13 |
| CA2164332A1 (en) | 1994-12-22 |
| EP0788651A1 (en) | 1997-08-13 |
| EP0932163A2 (en) | 1999-07-28 |
| AU7058594A (en) | 1995-01-03 |
| WO1994029880A1 (en) | 1994-12-22 |
| US5790964A (en) | 1998-08-04 |
| EP0932163A3 (en) | 1999-08-04 |
| US5564104A (en) | 1996-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5564104A (en) | Methods of removing radioactively labled biological molecules from liquid radioactive waste | |
| CA1226215A (en) | Immunoassay of antigens | |
| US4059685A (en) | Immobilized immunoadsorbent | |
| US4180383A (en) | Chamber holder for immobilized immunoadsorbent | |
| US6416671B1 (en) | Methods for removing hazardous organic molecules from liquid waste | |
| US4338094A (en) | Macroencapsulated immunosorbent assay technique | |
| US4166102A (en) | Immobilized immunoadsorbent | |
| EP0105714B1 (en) | Immunoassay of antigens | |
| US4554088A (en) | Magnetic particles for use in separations | |
| US4695392A (en) | Magnetic particles for use in separations | |
| US4280816A (en) | Macroencapsulated immunosorbent assay technique and element therefor | |
| EP0122695B1 (en) | Immunoassay for antigens employing supported binder | |
| GB1564580A (en) | Specific binding assay method and test kit employing polystyrene as separating agent | |
| DK147809B (da) | Immobiliseret immunoadsorbent | |
| CA1118364A (en) | Charcoal coated absorbent device | |
| JPH0459587B2 (enExample) | ||
| AU687033B2 (en) | Undercoating of solid phase surfaces and direct coating method | |
| JPS626185B2 (enExample) | ||
| EP0007229B1 (en) | Assay invoving labelled substances employing a re-usable immobilised binder | |
| EP0007744B1 (en) | Assay for thyroid hormone binding capacity | |
| Nustad et al. | Monosized Polymer Particles in Immunoassays: Applications and Immunochemistry | |
| Boche et al. | Adsorption to glass and specific antibody inhibition of iodine125 labeled influenza virus | |
| Bombardieri et al. | A technique for immunoassay of human IgG | |
| JPS61110059A (ja) | 免疫学的分析方法 | |
| Neurath et al. | 125 I-labeled anti-2, 4-dinitrophenyl (DNP)-antibodies: A universal reagent for solid phase radioimmunoassays |