JPH0940531A - Hair tonic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic that has sustained-release hair tonic effects, such as hair growing, depilation-preventive and dandruff-preventive effects, by using eugenol in a specific form as a 5α-reductase activity inhibitor. SOLUTION: This hair tonic is obtained by blending an eugenol glycoside. The blending ratio is preferably 0.1-10.0wt.% to the whole quantity of the hair tonic. The eugenol glycoside can be easily synthesized by a well known method. Among eugenol glycosides, glucose glycosides, specifically eugenyl α-D-glucoside and/or eugenyl β-D-glucosicle, are preferable because of degree of manifestation of their effects. In this case, although β-glucosides are more preferable, α- glucosides may be contained without affecting the effects. This hair tonic can be formulated in such a form as hair tonic, hair lotion and hair mousse which are directly applied to the scalp.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair nourishing agent containing an eugenol glycoside, and more specifically, it has the ability to inhibit the activity of 5α-reductase by eugenol released by the scalp-resident bacteria and has a hair-growing effect. The present invention relates to a hair nourishing agent excellent in hair loss prevention effect and dandruff prevention effect.

[0002]

2. Description of the Related Art A hair nourishing agent containing a scalp blood circulation-promoting substance such as capsicum tincture, assembly extract, ginseng extract, nicotinic acid and methyl nicotinate has been known. However, a substance that is effective enough to exert effects such as hair growth, hair loss prevention and dandruff prevention has not yet been developed. Recently, it has been suggested that hormones are involved in hair growth. In other words, the male hormone (testosterone) is 5α-in hair follicles including hair matrix cells.
The reductase (delta ^4-3-keto steroid 5α- oxidoreductase), is activated to active androgen (dihydrotestosterone), further binds to the receptor, is incorporated into the nucleus, to transmit information at the DNA level.
The transmitted information controls enzyme synthesis involved in keratin synthesis, suppresses keratin synthesis in hair, reduces hair growth, and finally promotes hair loss. Therefore,
In the development of hair nourishing agents, attention has been focused on research on the activity inhibitor of 5α-reductase, which is an androgen activating enzyme in hair and scalp.

[0003]

Eugenol is mentioned as a 5α-reductase activity-inhibiting substance which is effectively incorporated into a hair nourishing agent (JP-A-63-284125). However, it has been suggested that eugenol has a peculiar odor component, is low in stability, shows insolubility in an aqueous system, and may have sensitizing property in terms of safety.
Therefore, it is an object of the present invention to provide a hair nourishing agent which is easy to produce, has low skin irritation, and is excellent in hair growth, hair loss prevention and dandruff prevention.

[0004]

Means for Solving the Problems The present inventor has conducted studies to maintain the inhibition of 5α-reductase activity of eugenol and to solve the above-mentioned problems. As a result, the hair nourishing agent containing eugenol glycoside has the above-mentioned properties. The inventors have found that the object can be achieved, and have completed the present invention. The eugenol glycoside referred to in the present invention means monosaccharides such as glucose, galactose, mannose, rhamnose, xylose, glucosamine and galactosamine, saccharides such as disaccharides such as lactose, maltose and sucrose, and eugenol are O-glucosides. It is a bound compound.

The present inventors have already found that fragrance glycosides such as eugenol glycosides are appropriately decomposed into eugenol and sugar moieties by skin-resident bacteria and scalp-resident bacteria.
Japanese Patent Application No. 6-303204 as a sustained release fragrance composition for human body
This time, the present inventor has found that eugenol glycoside particularly exhibits a sustained-release hair nourishing effect and exhibits excellent properties as a hair nourishing agent.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The eugenol glycoside used in the present invention can be easily synthesized by a known method. For example, U. S. P. According to the method for synthesizing arbutin described in No. 3201385, eugenol glycoside as a mixture of α-form and β-form can be obtained. Also, Flavo
ur and Fragrance Journal
According to the method for synthesizing glucovanillin described in (Vol 4, 163-167, 1989), only β-form can be synthesized. Among these eugenol glycosides, glucose glycosides are preferable because of the degree of expression of its effect.
Specifically, it is eugenyl α-D-glucoside and / or eugenyl β-D-glucoside. In this case, β-
The body is preferable, but the effect is not particularly problematic even if the α-body is contained.

The amount of the eugenol glycoside used in the present invention is 0.1 with respect to the total weight of the hair nourishing composition of the present invention.
It is preferably ˜10.0% by weight (hereinafter abbreviated as “wt%”), and more preferably 0.1 to 8.0% by weight. If the blending amount is less than 0.1 wt%, the intended effect of the present invention may not be sufficient, while if it exceeds 10.0 wt%, it is often not possible to expect an improvement in the effect commensurate with the increase.

The hair nourishing agent of the present invention can be produced by a conventional method by blending it into a dosage form such as hair artic, hair lotion, hair armose, etc., which is directly applied to the scalp.

The hair nourishing agent of the present invention includes pigments, fragrances, germicides, preservatives, keratolytic agents, antiandrogens, hair nourishing agents,
Antioxidants and the like can be appropriately blended within the range where the object of the present invention is achieved.

[0010]

EXAMPLES The present invention will be described in detail below based on Examples and Comparative Examples.

The C3H mouse hair growth promoting effect test method, human scalp hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) C3H mouse hair growth promoting effect test method C3H mouse (8 weeks old, male, average weight 35 g) back skin (2 cm × 4 cm) was shaved with an electric clipper and shaver, and from the next day, Examples and Comparative Examples Each sample was applied to the skin of the test site twice a day in the morning and 0.2 ml per animal for two consecutive weeks. For each sample, 10 animals were used per group. On the 14th day from the start of application, the skin of the test portion of each sample was photographed with a video camera, and the areas of the shaved portion and the hair growth portion were measured with an image analyzer. The hair nourishing effect was determined by comparing the hair growth rate (%) shown below with that of the control group. Hair growth rate (%) = (Area of hair growth part / Area of shaved part) × 1
00

(2) Test method for human scalp hair growth promoting effect: Hair of 5 cm above the ears of the heads of 10 test subjects who are male pattern baldness is circular with a diameter of 1 cm at two left and right positions. About 3 ml of each sample of the Example and Comparative Example was applied to the left side twice daily in the morning and evening on the test site that was shaved, and compared with the untreated right side. The effect was determined on the 28th day after the test started.
Twenty hairs each on the left and right test sites were shaved, and the degree of promotion of hair growth was evaluated by the value obtained by the following formula. Degree of hair growth promotion = (B) / (A) (A): Average value of length of 20 right hairs (untreated) hairs (B): Left hair (samples of Examples and Comparative Examples applied) 2
Average length of 0 lines

(3) Practical Test Method 20 heads of male pattern baldness test subjects were evaluated for their effects after being applied twice daily in the morning and evening twice a day for 6 consecutive months. The test results show that for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect, “hair has become bristle or hair has increased,” “hair loss has decreased,” and “hair loss has decreased. And the number of respondents.

Examples 1 to 9 and Comparative Examples 1 to 9 (Oily Hearthonic) As shown in Table 1, various hair growth-promoting substances were blended in the following raw material compositions to prepare respective hairnics. The above-mentioned various tests were carried out.

[0016]

(2) Purification method In the component (B), nicotinic acid and methyl nicotinate are
In the component (A), capsicum tincture and eugenol glycoside are dissolved in the component (C), the components (A) and (B) are uniformly dissolved, and then the components (A) and (B) are added. Mix and disperse with stirring, and then fill the container. At the time of use, the contents should be evenly dispersed by shaking. As the eugenol glycoside, a mixture of α-form and β-form (3: 7) or β-form was used.

(3) Characteristics Table 1 shows the results of various tests of each oily hair art. As shown in Table 1, Examples 1 to 5 of the present invention
The hair nourishing agent of 9 has a higher hair growth promoting effect as compared with the comparative example,
It was effective in preventing hair loss and dandruff. In addition, when a human patch test was performed in advance by 10 people for each sample, the samples of Comparative Examples 2 to 5 were found to have mild skin irritation in 2 to 3 people. Didn't do it.

[0019]

[Table 1]

[0020]

Industrial Applicability As described above, the present invention is excellent in the effects of hair growth, hair loss prevention and dandruff prevention, and also has the ability to inhibit 5α reductase activity by eugenol released by scalp indigenous bacteria, and further has skin irritation. It is obvious to provide a hair nourishing cosmetic composition having a low hair price. That is, the present invention, by using eugenol as a glycoside such as glucose, galactose, xylose, and maltose, it reduces the characteristic aroma, enhances the substance stability and the safety to human skin, and dissolves in an aqueous system. Improved. Furthermore, eugenol glycosides were appropriately decomposed into eugenol and sugar moieties by resident scalp bacteria, and inhibited the process in which male hormone was activated by active male hormone (dihydrotestosterone). It is presumed that this 5α-reductase activity inhibiting ability suppresses the production of active male hormone (dihydrotestosterone) in hair papilla cells, further normalizes the scalp metabolic function, and enhances the antidandruff effect.

Claims (1)

[Claims] 1. A hair nourishing agent comprising an eugenol glycoside.