JPH09266939A - Ampul-cum-disposable syringe body in which injection is sealed, ampul-cum-disposable syringe body in which injection can be sealed, and method for sealing injection in ampul-cum-disposable syringe body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an ampul-cum-disposable syringe body in which an injection is included when forwarded from a pharmaceutical company, which can be opened easily and hygienically when used and which can be used only by mounting a needle and an extruder, an empty ampul-cum-disposable syringe body with the inside sealed in a disinfected state in which the injection can be sealed, and a method for sealing injection in the empty ampul-cum-disposable syringe body. SOLUTION: A thin inner bag 1 is provided inside a barrel 2 so as to form a double structure, a cylinder 5 is provided at the top of a needle hub 4, a thin cutting part 6 is provided on a part of the cylinder 5, an injection is included from the extremity of the cylinder 5, and thereafter, the cylinder 5 is closed to seal the injection in. When it is used, the cutting part 6 is cut off with a hand, a needle is mounted, and the inner bag is crushed with an extruder to give the injection.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION This invention is applied to pharmaceutical companies in
It has a function as an ampoule where the injectable agent is sealed and can be stored and transported, and when used by a doctor, it can be easily opened and the needle and pusher can be attached. Of the ampoule / disposable injection cylinder that can be used as a cylinder and that seals the injection, and the empty ampoule and disposable injection cylinder that seals the injection,
The present invention relates to a main body which does not include an extruder, and a method for sealing an injection in an empty ampoule / disposable syringe barrel main body capable of sealing the injection.

[0002]

2. Description of the Related Art Conventionally, disposable syringes have been widely used. However, they are merely glass syringes replaced with resin, and the sterilization work can be omitted. It was Therefore, as in the case of the glass injection cylinder, the injection is used by being sucked from the ampoule while being measured while being used. This is because the conventional injection cylinder does not have a sealed structure, and thus the injection cannot be stored in the injection cylinder for a long time.

[0003] Depending on the type of injection, the amount to be injected is often constant or can be classified into several types. For example, the amount of injectables for influenza vaccination varies depending on the age of the recipient,
It can be classified in several ways. In such a case, if a certain amount of injection is already contained in the syringe, it is convenient because it is not necessary to weigh out the injection each time, but with the conventional syringe, it is necessary to weigh out each time, which is inconvenient. Met. Also, the doctor
When carrying a medical bag, it was inconvenient because both the empty syringe and the ampoule containing the injection had to be carried.

[0004]

[Problems to be Solved by the Invention]

Ampoule / disposable syringe barrel body that seals the injectable drug If the injectable drug is enclosed in the disposable syringe barrel at the time of shipment from the pharmaceutical company, the user does not need to weigh the injectable drug, and You no longer have to carry both an empty syringe and an ampoule. In order to make such an ampoule and a disposable syringe, it is necessary to solve the following problems. (B) A completely sealed structure that prevents the injection from touching the air. (B) It should be possible to open it easily and hygienically when using it. (C) Being able to inject by almost the same operation as a conventional syringe.

Ampoule / disposable syringe main body capable of sealing injections For pharmaceutical companies, an empty ampoule / disposable injection cylinder capable of sealing injections is ordered and delivered to another company, and only the injection sealing work is performed. It would be efficient to do this. In such a case, it is inconvenient for the pharmaceutical company to sterilize the inside of the delivered ampoule / disposable syringe and then inject the injection. When a pharmaceutical company injects an injection into an empty ampoule / disposable syringe barrel body, it is desirable that the inside be sterilized in advance and that the sterilized state be maintained until immediately before the injection. In the case of normal disposable syringes, gas sterilization is performed after molding,
Since they are packaged one by one, the sterilized state is maintained until the package is opened. However, it is inconvenient if the empty ampoule / disposable syringe barrel body is packaged one by one because the pharmaceutical company must unpack the package when injecting the injection. Therefore, it is necessary to solve the following problems. (D) The inside is sterilized, and the sterilized state inside is maintained even without packaging. (E) It should be possible to easily inject an injection and then easily seal it.

Method of sealing injection in ampoule / disposable syringe barrel body Further, as a method for pharmaceutical companies to seal injections, it is necessary to solve the following problems. (F) Easy injection and sealing of injections.

[0007]

[Means for Solving the Problems]

Ampoule and single-use syringe barrel body that seals the injectable drug The conventional disposable syringe barrel has an open tip on the needle mounting part, and the rubber piston is also perturbed inside the barrel, so it is hermetically sealed. It cannot be said that it is done. Both of them need to be closed in order to have a closed structure. In order to eliminate the perturbation part and to make it possible to push out the injection, you can put the injection in a thin and deformable bag and crush the bag by hand like a dropper to release the injection. it can. However, if the bag is made thin, it is difficult to handle because it is easily deformed, and it is difficult to control the extrusion speed of the injection freely. Conversely, if the bag is made thick, the injection will flow back due to the restoring force of the bag. There is a fear that the same operability as the conventional syringe cannot be expected.

[0008] Therefore, similar to the conventional injection cylinder, a double structure in which a thin inner bag 1 is provided inside a rigid outer cylinder 2 is used, and the injection is put in the inner bag 1 and the pusher 8 is attached to the outside. It is inserted into the cylinder 2 and the inner bag 1 is crushed to push out the injection. In this case, the injection is contained in the inner bag 1 and the perturbation part does not come into contact with the injection, so there is no risk of exposure to the outside air. Moreover, since the inner bag 1 is held by the outer cylinder 2, the bag is not deformed and difficult to handle. Furthermore, since the outer bag 2 can prevent the inner bag 1 from being damaged, the inner bag 1 can be made thin, and therefore, the restoring force of the inner bag 1 may cause the injection solution to flow backward. Therefore, the operability similar to the conventional one can be expected. Inner bag 1
Cut the thin resin tube 7 to an appropriate length,
A bag may be used in which one of the ports is thermocompression-bonded and sealed. Since the inner bag 1 and the other portion can be made of different kinds of resins, the selection range of the resin is widened. Therefore, a hard resin can be selected for the outer cylinder 2 and the needle mounting portion 4, and a soft and transparent resin can be selected for the inner bag 1.

In order to close the side of the needle mounting portion 4, a tubular body 5 is connected to the tip of the needle mounting portion 4, an injection agent is put from the tip of the tubular body 5, and after the injection agent is put, The mouth of the tubular body 5 may be plugged 9 or the passage of the tubular body 5 may be sealed by a method such as thermocompression bonding. The tubular body 5 may have a cylindrical shape or another shape. Also, it need not be straight.

In order to easily and hygienically open the bag, the connecting portion between the needle mounting portion 4 and the tubular body 5 should be thin, and a cutting portion 6 should be provided so as to be easily broken. . When the tubular body 5 is used, the tubular body 5 can be easily and sanitarily opened because it can be broken at the cutting portion 6 by applying a force to bend it by hand.

Ampoule / disposable syringe barrel body that can seal injections The internal sterile condition can be maintained easily without packaging,
In order to be able to inject an injection and to easily seal it after injection, connect one mouth of a thin tube 7 of an appropriate length to the back side of the bottom surface 3 and The mouth is left unsealed, one end of the tubular body 5 is connected to the tip of the needle mounting portion 4, the other mouth is left unsealed, and gas sterilization is performed in this state. Then, both the open mouth of the tube 7 and the open mouth of the tubular body 5 are sealed in the sterilization chamber. Despite this, the portion of the inner bag 1 is housed in the outer cylinder 2, and the bottom surface 3 is fitted into one opening of the outer cylinder 2 for assembly. In this way, the sterilization state inside can be maintained without packaging. When injecting an injection in a pharmaceutical company, the tip of the tubular body 5 may be cut off in a sterilized injection device, and after the injection is injected, the tip of the tubular body 5 may be sealed again.

Method of sealing injection agent in ampoule / disposable syringe barrel body In order to easily inject the injection agent, the inside of the empty ampoule / disposable syringe barrel body is already sterilized, and therefore injection agent is injected. Sometimes it is not necessary to sterilize.
Moreover, it is preferable that it can be easily sealed even after injection. To do this, the interior is sterilized and sealed,
If an empty ampoule / disposable injection cylinder body is injected by cutting off the sealed portion of the tubular body 5 in the injecting agent injecting device, immediately after the injection, the mouth of the tubular body 5 can be sealed again. Good.

[0013]

1 to 7, an ampoule-cum-disposable injection-cylinder main body capable of sealing an injection, and a method of using the ampoule-cum-disposable injection-cylinder main body in which an injection is sealed, and an ampoule-disposable A method of sealing the injection agent in the syringe barrel body will be described. FIG. 1 is a cross-sectional view showing a state of a pre-stage for producing an ampoule / disposable injection cylinder body capable of sealing an injection, one side of a tube 7 is connected to the back side of the bottom surface 3, and the other side is not yet opened. It is not sealed and the outer cylinder 2 is not attached. In addition, the needle mounting portion 4
Although the tubular body 5 is connected to the tip of the, the passage of the tubular body 5 is not sealed. Gas sterilization is performed in this state.
Since the tube 7 and the tubular body 5 are not sealed, it is possible to surely sterilize the inside. FIG.
The structure shown in FIG. 1 is sterilized, and then the tubular body 5
9 is a cross-sectional view showing a state in which the open mouth of the tube 7 is sealed. In FIG. 2, the shape and size of the inner bag 1 are shown inflated for easy understanding, but in practice, it is better to remove air. FIG. 3 shows a cross-sectional view of what is shown in FIG. 2 with the outer cylinder 2 attached to form an ampoule / disposable injection cylinder body capable of sealing an injection. The pharmaceutical company receives it in this state and only performs the injection work of the injection. Since the internal sterilization state is maintained, the pharmaceutical company can order a large amount and keep it in inventory. 4 is an ampoule / disposable injection cylinder body shown in FIG.
FIG. 3 is a cross-sectional view showing a state in which the passage of the cylindrical body 5 is opened and the injection 10 is put in the inner bag 1. The injection work of the injection is performed in a sterilized injection device, and the tubular body 5 is cut immediately before the injection. FIG. 5 shows a cross-sectional view of an injection ampoule-filled ampoule / disposable injection tube main body in which the injection agent is injected but the passage of the tubular body 5 is sealed as shown in FIG. . FIG. 6 is a cross-sectional view showing a state in which the tubular body 5 of the ampoule / disposable injection barrel body shown in FIG. Since the cutting portion 6 is thin, it can be bent by simply applying force to bend the tubular body 5 by hand. FIG. 7 shows a cross-sectional view of the state in which the needle 11 and the pusher 8 are attached to the state shown in FIG.
The pusher 8 is the same as that used in a normal disposable syringe, and has a rubber piston 12 at the tip. Extruder 8 like a normal syringe
The air in the inner bag 1 can be expelled by pressing, and then the injection can be performed. An air hole 13 is provided on the side surface of the outer cylinder 2 near the bottom surface 3. This is a hole for allowing air to escape between the inside of the outer cylinder 2 and the piston 12. In the case of intravascular injection, in order to confirm whether the needle tip has reached the blood vessel, pull out the pusher once before pushing out the injection to confirm that blood enters the syringe May be injected. If you want to do this, close the air hole 13 with your finger and pull out the pusher 8,
Since the pressure inside the inner bag 1 can be reduced, blood can be sucked.

[0014]

【Example】

Example 1 of Ampoule / Disposable Injection Cylinder Body Sealed with Injectable Solution One example will be described based on the sectional view of the ampoule / disposable injection cylinder body sealed with an injectable agent shown in FIG. The tubular body 5, the needle mounting portion 4, and the bottom surface 3 are made of resin and are integrally formed. The outer cylinder 2 is also made of the same resin, but is molded as a separate body. Outer cylinder 2 and bottom 3
It is a mating type and does not require adhesive. The inner bag 1 is made of a resin tube 7 which is soft, thin and durable. The mouth of the inner bag 1 is connected to the connection edge 14 provided on the back side of the bottom surface 3 by thermocompression bonding. It is convenient for the inner bag 1 to be transparent because the liquid volume can be seen from the outside. The thickness of the tubular body 5 is about the same as that of the needle mounting portion 4. The length of the tubular body 5 needs to be at least 1 cm or more so that the cutting portion 6 can be easily broken. The cutting portion 6 is made thin by reducing the outer diameter of the passage instead of increasing the inner diameter of the passage. In this way, even if some burrs are left on the cut surface after being folded at the cutting portion 6, it does not hinder the attachment of the needle. In this embodiment, the passage of the tubular body 5 is sealed by thermocompression bonding. An air hole 13 for letting the air inside the outer cylinder 2 escape to the side surface of the outer cylinder 2 near the bottom surface 3.
Is provided. Air hole 13 if not for vascular injection
Need not necessarily be provided on the outer cylinder. For example, a space may be provided between the piston of the pusher and the outer cylinder to allow air to escape, or a through hole may be formed in the piston.

Embodiment 2 of Ampoule / Disposable Injection Cylinder Body Sealed with Injections Another embodiment will be described with reference to the sectional view of the ampoule / disposable injection cylinder body sealed with injections shown in FIG.
In this embodiment, in order to seal the tubular body 5, a T-shaped plug 9 is fitted into the mouth of the tubular body 5. When using
To open, the T-shaped stopper 9 can be easily folded by twisting a force so that the cutting portion 6 has a low strength. The shape of the stopper 9 need not be limited to the T shape.

Example of Ampoule / Disposable Injection Cylinder Main Body Capable of Sealing Injectable Solution An example will be described with reference to the sectional view of the ampoule / disposable injection cylinder main body capable of sealing an injection agent shown in FIG. The structure is basically the same as the ampoule / disposable syringe barrel main body in which the injection is sealed as described in Example 1, but the tubular body 5 is cut and short when the injection is injected. Therefore, it is necessary to lengthen it in advance by that amount. The thickness of the tubular body 5 may be slightly thicker or may be thicker only at the tip in order to facilitate injection of the injection. In FIG. 3, in order to make the shape and size of the inner bag 1 easier to understand, the inner bag 1 is drawn as if it contains air, but in reality, the air inside the inner bag 1 should be removed. But,
Easy to inject injections.

[0017]

EFFECTS OF THE INVENTION The ampoule / disposable syringe barrel body in which the injection is sealed according to the present invention has both the function as an ampoule and the function as a disposable syringe. Therefore, the pharmaceutical company must encapsulate the injection. It can be opened easily and hygienically at the time of use, and it can be injected in almost the same operation as a conventional syringe by attaching a needle and an extruder.
Also, there is no need to carry both an empty syringe and ampoule. Since the ampoule / disposable syringe barrel body according to the present invention that can seal the injection is sealed, the inside can be maintained in a sterilized state. When injecting the injection, the cylindrical body 5 may be cut and opened immediately before the injection, so that it is not necessary to sterilize the inside of the injection. Also, it can be easily sealed after injection. The method of sealing the injection in the ampoule / disposable syringe barrel body of the present invention uses the ampoule / disposable syringe barrel body which has already been sterilized and can seal the empty injection medium, so that the sterilized state is maintained until just before the injection. ,
At the time of injection, the injection work can be performed without sterilizing the inside, and sealing is also easy.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing a state in a pre-stage of making an ampoule / disposable syringe barrel body capable of sealing an injection.

FIG. 2 is a cross-sectional view showing a pre-stage state in which an ampoule / disposable syringe barrel body capable of sealing an injectable solution is produced.

FIG. 3 is a cross-sectional view of an ampoule / disposable syringe barrel body capable of sealing an injection.

FIG. 4 is a cross-sectional view showing a state where a tubular passage is opened and an injection is put in an inner bag.

FIG. 5 is a cross-sectional view of an ampoule / disposable syringe barrel body in which an injection is sealed.

FIG. 6 is a cross-sectional view showing a state in which the tubular body is cut at a cutting portion and opened.

FIG. 7 is a cross-sectional view showing a state during use.

FIG. 8 is a cross-sectional view of an ampoule / disposable syringe barrel body in which an injection is sealed.

[Explanation of symbols]

 1 ... Inner bag 2 ... Outer cylinder 3 ... Bottom surface 4 ... Needle mounting portion 5 ... Cylindrical body 6 ... Cutting portion 7 ... Tube 8 ... Extruder 9 ... ..Stoppers 10 ... Injections 11 ... Needles 12 ... Pistons 13 ... Air holes 14 ... Connection edges

Claims (6)

[Claims] 1. A disposable syringe made of resin,
A thin resin inner bag (1) containing an injection is put inside an outer cylinder (2), and the mouth of the inner bag (1) is placed on the bottom surface (3).
A double-structured outer cylinder connected to the back side of the inner bag (1) so that the inside of the inner bag (1) and the passage of the needle mounting portion (4) can be connected to each other, and at the tip of the needle mounting portion (4), The tubular body (5) is connected, the connecting portion is made thin so that it can be easily broken, the cutting portion (6) is provided, the passage of the tubular body (5) is sealed, and the injection is sealed. Ampoule and disposable syringe body 2. A disposable syringe made of resin,
One end of a thin resin tube (7) is sealed by thermocompression bonding, and an inner bag (1) containing an injection agent is placed inside an outer cylinder (2) to form an inner bag (1). The mouth of is connected to the back side of the bottom surface (3) so that the inside of the inner bag (1) and the passage of the needle mounting part (4) can be communicated with each other to form a double-structured outer cylinder for needle mounting. The tubular body (5) is connected to the tip of the portion (4), and the connecting portion is thinned so that the cutting portion (6) can be easily broken, and the passage of the tubular body (5) is provided. Ampoule and disposable syringe body that can seal injections 3. A disposable syringe made of resin,
Empty, thin plastic inner bag for injectables (1)
Inside the outer tube (2), the mouth of the inner bag (1) is connected to the back side of the bottom surface (3), and the inside of the inner bag (1) and the passage of the needle mounting portion (4) are connected. A double-structured outer cylinder that can communicate with the needle attachment part (4), and the tubular body (5) is connected to the tip of the needle attachment part (4) so that the connection part is thin and easily broken. And the ampoule / disposable injection barrel body which is provided with the cutting part (6) and seals the passage of the tubular body (5) and which can seal the injection. 4. An inner bag (1) obtained by sealing one end of a thin resin tube (7) by thermocompression bonding to form an inner bag (2) of a resin disposable syringe. And connect the mouth of the inner bag (1) to the back side of the bottom surface (3),
A double-structured outer cylinder that allows communication between the inside of the inner bag (1) and the passage of the needle mounting portion (4), and the needle mounting portion (4)
The tubular body (5) is connected to the tip of the, and the cutting portion (6) is provided in which the connecting portion is made thin so that it can be easily broken,
Ampoule / disposable syringe barrel body that seals the passage of the tubular body (5) and can seal the injection. 5. A resin-made disposable syringe barrel,
Empty, thin plastic inner bag for injectables (1)
Inside the outer tube (2), the mouth of the inner bag (1) is connected to the back side of the bottom surface (3), and the inside of the inner bag (1) and the passage of the needle mounting portion (4) are connected. A double-structured outer cylinder that can communicate with the needle attachment part (4), and the tubular body (5) is connected to the tip of the needle attachment part (4) so that the connection part is thin and easily broken. In addition, the cutting portion (6) is provided, and the passage of the tubular body (5) is sealed, and the sealed portion of the tubular body (5) of the ampoule / disposable injection barrel body capable of sealing the injection is cut off. , The passage is opened, the injection is injected into the inner bag (1) through the cutting port, and then the passage of the tubular body (5) is sealed again to seal the injection in the ampoule / disposable syringe barrel body. how to. 6. A thin resin tube (7) having one opening sealed by thermocompression bonding to form an inner bag (1), which is used as a resin disposable syringe barrel and an outer barrel (2). It was housed inside and the mouth of the inner bag (1) was connected to the back side of the bottom surface (3) so that the inside of the inner bag (1) and the passage of the needle mounting part (4) could be connected. With an outer cylinder having a heavy structure, the tubular body (5) is connected to the tip of the needle mounting portion (4), and the connecting portion is
A tubular body (5) of an ampoule / disposable syringe barrel main body, which is thin and easily breakable, is provided with a cutting part (6), and seals the passage of the tubular body (5) and can seal an injection. The sealed part of the is cut off to open the passage, the injection is injected into the inner bag (1) through the cutting port, and then the passage of the tubular body (5) is closed again, whereby the ampoule also serves as an ampoule. A method of sealing an injectable drug in a disposable syringe body.