JPH09222587A - Detergent for oxygen permeable hard contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enhance safety and to sufficiently remove the stains of an oxygen permeable contact lens and to enhance the handling thereof by forming the detergent in a granular from contg. percarbonate, protease, surfactant and neutralizing agent and using the detergent by dissolving the same in water. SOLUTION: This detergent is formed to the granular form contg. the percarbonate, the protease, the surfactant and the neutralizing agent and used by dissolving the same in water. At least either of the percarbonate and the protease is formed to the granular form coated with a water-soluble coating agent. Further, the percarbonate is sodium percarbonate, the protease is subtilisin, the surfactant is a nonionic surfactant and the neutralizing agent is thiosulfate and boric acid. The water for dissolving the detergent of this case refers to city water, refined water, distilled water physiological salt soln. or an oxygen permeable contact lens preserving liquid contg. commercially marketed surfactant.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cleaning agent used for cleaning contact lenses, particularly oxygen permeable hard contact lenses.

[0002]

2. Description of the Related Art For cleaning oxygen-permeable hard contact lenses, conventionally, a chlorine-based cleaning agent has been used as in general contact lenses. This is because the chlorine-based cleaning agent has a high degreasing power and a high protein decomposing ability, so that stains can be removed in a short time. However, chlorine is dangerous because it causes irritation to the eye and causes inflammation of the eye, and it is necessary to thoroughly wash the contact lens before wearing it, which is troublesome to handle. Therefore, from the viewpoint of safety, enzyme-based cleaning agents have been developed in recent years. This utilizes the proteolytic activity of the enzyme to remove dirt.

[0003]

On the other hand, while the enzyme type cleaning agent performs gentle cleaning, the cleaning ability such as degreasing property is inferior to that of the chlorine type cleaning agent, and there is a problem that stains cannot be sufficiently removed. In particular, an oxygen-permeable contact lens can be worn for a long time, so that dirt easily adheres and firmly adheres. Therefore, under the present circumstances, the oxygen-based cleaning agent does not sufficiently act on the oxygen-permeable contact lens. The present invention has been made in consideration of the above circumstances, and provides a cleaning agent having a high safety and a cleaning power capable of sufficiently removing dirt on an oxygen-permeable hard contact lens and having good handleability. The purpose is to do.

[0004]

The cleaning agent of the present invention is in the form of granules containing a percarbonate, a proteolytic enzyme, a surfactant and a neutralizing agent, and should be dissolved in water before use. Further, at least one of the percarbonate and the proteolytic enzyme is in the form of granules coated with a water-soluble coating agent, and the percarbonate is sodium percarbonate and a proteolytic enzyme. Is a subtilisin, the surfactant is a nonionic surfactant, the neutralizing agent is thiosulfate and boric acid,
When dissolved in water, the sodium percarbonate contained 0.1-5.
0 "% and the subtilisin content is 0.0001-0.
It is characterized in that it is prepared to have a decomposed oxygen activity of 01 unit / ml. The water in which the cleaning agent of the present invention is dissolved refers to tap water, purified water, distilled water, physiological saline, or a commercially available surfactant-containing oxygen-permeable contact lens preservation solution. .

In the present invention, the percarbonate is a peroxocarbonate in which hydrogen peroxide is coordinated to the carbonate. This percarbonate is stable in the dry state, but when dissolved in water it decomposes rapidly to produce hydrogen peroxide. Oxygen is released from this hydrogen peroxide, and this free oxygen decomposes organic substances. Therefore, it is effective in removing lipids. As this percarbonate,
One or more of potassium percarbonate and sodium percarbonate can be used. N for sodium percarbonate
_{a 2 CO 3 · H 2 O} 2, Na2CO 3 · 2 / 3H 2 O 2
Other chemical formulas can be selected. The blending ratio of the percarbonate is determined by the concentration of the cleaning agent of the present invention when it is dissolved in water since the cleaning agent of the present invention is used by dissolving it in water. For example, when sodium percarbonate is used as the percarbonate, it dissolves in water at 0.1 to 5.0%, preferably 1.0 to
The blending ratio is set so that the concentration becomes 3.0%.

[0006] The proteolytic enzyme is one which decomposes a protein by its simple white-degrading activity. As this proteolytic enzyme, one or more such as subtilisin and trypsin can be selected. The proteolytic enzyme alone decomposes a protein, but the present invention is characterized in that it is used together with a percarbonate. That is, the proteolytic activity of the above-mentioned proteolytic enzyme is dramatically enhanced in the presence of percarbonate. The rationale for this is not clear yet, but because oxygen generated from percarbonate enhances enzyme activity and percarbonate decomposes lipids that are difficult to decompose by proteolytic enzymes, it is possible to directly attack proteins. It seems to be because. In any case, in the coexistence with percarbonate, the detergent of the present invention can strongly remove stains based on an empirical rule that protein degradability is synergistically enhanced. The mixing ratio of this proteolytic enzyme was also determined based on the time of dissolution in water. In the case of subtilisin, 0.0001 unit / ml /
It is formulated to have a degrading enzyme activity of 0.01 unit / ml.

The surfactant promotes contact between the contact lens and water due to its surface activity. The cleaning target of the cleaning agent of the present invention is an oxygen-permeable hard contact lens,
This contact lens has hydrophobicity. The surface-active agent improves the wettability of the surface of this hydrophobic contact lens, and promotes contact between the lens surface and water. As a result, the percarbonate and the proteolytic enzyme in the aqueous solution effectively act on the lens surface to remove the stain. As such a surfactant, a nonionic surfactant is preferable from the viewpoint of irritability to the eye, and a Bluronic surfactant (trade name) is particularly effective. The mixing ratio of the surfactant is about 10%, and is not particularly limited. The neutralizing agent is used to neutralize the liquid property of the detergent, more preferably to weak alkaline of about pH 8 and to stabilize the liquid property. By making the cleaning agent liquid neutral or weakly alkaline, the attack on contact lenses disappears,
It can be used safely, and the cleaning agent used for cleaning contact lenses can be used as it is as a storage solution. As such a neutralizing agent, thiosulfate and boric acid are used. Examples of thiosulfates include sodium thiosulfate (Na ₂ S ₂ O ₃ ) and calcium thiosulfate (Ca
S ₂ O ₃ ) or the like can be selected, but sodium thiosulfate used as an antidote is particularly preferable. Boric acid (H
₃ BO ₃ ) is a weak acid and its use with thiosulfates reduces the alkalinity of thiosulfates. Thereby, the liquid property of the cleaning agent can be made neutral, more preferably weakly alkaline. Boric acid itself has bacteriostatic and antiseptic properties. Therefore, by using boric acid, it is possible to prevent the growth of bacteria on the lens surface and the generation of mold. As such boric acid, any of orthoboric acid, metaboric acid, and tetraboric acid can be used.

The detergent of the present invention is supplied in the form of granules having the above composition. In use, the contact lens is dissolved in one of the above-mentioned various kinds of water, and the contact lens is immersed in this aqueous solution and left standing overnight (for example, 6 to 8 hours) to wash it. By this immersion, not only stains on the lens surface can be removed, but also the coloring inside the lens can be bleached. In addition, the lens does not become discolored even when used over time. When supplied in the form of granules, the mutual contact of each compound may decompose the percarbonate or reduce the decomposition activity of the proteolytic enzyme. Therefore, each compound may be individually packaged, dissolved and mixed in purified water at the time of use. Not limited to this, in the present invention, a capsule may be prepared by coating either or both of percarbonate and proteolytic enzyme with a water-soluble coating agent. FIG. 11 shows an example of this capsule, in which the inner layer 1 is filled with percarbonate or proteolytic enzyme.
The outer layer 2 that encloses is composed of a water-soluble coating agent.
In the present invention, the dissolution time can be adjusted by appropriately changing the thickness of the outer layer 2. That is, the thickness of the outer layer 2 is used to adjust the time when the percarbonate and the proteolytic enzyme are effective. FIG. 2 shows another example of the capsule, which has four layers as a whole. The innermost first layer 3 is filled with either one of percarbonate and proteolytic scavenger, and the intermediate third layer 5 is filled with the other. Then, these compounds are fractionated by the second layer 4 composed of a water-soluble coating agent to prevent mutual contact,
The fourth layer 6 composed entirely of a water-soluble coating agent
It is wrapped by. FIG. 3 shows still another example of the capsule, which includes two of the first capsule 10 and the second capsule 20.
Each of the capsules 10 and 20 has a predetermined amount and is enclosed in a bag body 30. The inner layer 11 of the first capsule 10 is filled with percarbonate, and the inner layer 11 is wrapped with the outer layer 12 made of a water-soluble coating agent. The second capsule 20 is filled with an appropriate amount of a small capsule 21 filled with proteolytic enzyme and a small capsule 22 filled with a neutralizing agent composed of thiosulfate and boric acid. An outer layer 23 made of a water-soluble coating agent surrounds the whole 22. This second capsule 2
The small capsules 21 and 22 in 0 are the first capsules 10.
Alternatively, it has a two-layer structure similar to the capsule shown in FIG. In the capsule shown in FIG. 3, the first capsule 10 is dissolved at the beginning of contact with water (for example, after 15 seconds), and then the second capsule 20 is dissolved after a predetermined time (for example, 30 minutes) has elapsed. And it's capsule 1
The thickness of the outer layers 12, 23 of 0, 20 is adjusted. As a result, the organic substance containing the protein is decomposed by the action of the percarbonate until it has a simple structure, and the proteolytic enzyme acts on the organic substance in this state, so that the protein can be surely decomposed and the cleaning property is improved. As the bag for enclosing the capsules 10 and 20, a sheet material obtained by laminating an aluminum foil and a plastic film is used, which blocks light and moisture to decompose percarbonate and decompose protein. Inactivation of the enzyme can be prevented. As the water-soluble coating agent in these cases, HPMC (hydroxypropylmethylcellulose) PEG (polyethylene glycol), HEC (hydroxyethylcellulose) or gelatin can be appropriately selected.

[0009]

DETAILED DESCRIPTION OF THE INVENTION sodium percarbonate as percarbonate _{(Na 2 CO 3 · 2 /} 3H 2 O 2), subtilisin as proteolytic enzyme (trade name "Subtilisin A"), trade name surfactant "Emulgen PP-290 "(manufactured by Kao Corporation), sodium thiosulfate anhydride (Na ₂ S ₂ O ₃ ) and boric acid were selected as neutralizing agents, and a cleaning agent was prepared according to the following formulation example. In this case, the subtilisin A and sodium thiosulfate used were those coated with HPMC having a thickness of 1 μm or more. This coating film dissolves in water in about 20 to 30 minutes. (Formulation example) Sodium percarbonate 70.0 mg (38.8 wt%) Subtilisin A 2.0 mg (1.1 wt%) Emulgen PP-290 20.0 mg (11.2 wt%) Sodium thiosulfate 18.0 mg ( 10.0% by weight) Boric acid 70.0 mg (38.8% by weight) Total amount 180.0 mg Artificial protein soil Artificial lipid soiled oxygen permeable hard contact lenses are immersed in 3 ml of purified water, and the purified water is added. 0.2 g of the detergent having the above formulation was added to and dissolved. Immediately after dissolution, foaming was carried out for 30 seconds, and generation of oxygen was confirmed. Further, the entire amount was smoothly melted, there was no residue, and the pH was weakly alkaline with 8. Then, the removal state of these stains was observed over time. Table 1 shows the detergency against artificial protein stains, and Table 2 shows the detergency against artificial lipid stains. In these tables, the more "+", the greater the amount of adhered dirt, and "-" indicates that the adhered dirt disappeared. Comparative Examples A and B were similarly cleaned with a chlorine-based cleaning agent and an enzyme-based cleaning agent, respectively.

[0010]

[Table 1]

[0011]

[Table 2]

Table 3 shows the characteristics of each cleaning agent in consideration of the above cleaning results. "○○" is excellent, "○" is good,
“Δ” means a little, “X” means no. "Internal coloring"
Indicates the ability to remove the internal color of the contact lens, and "discoloration" indicates that the transparency of the lens surface is poor.

[0013]

[Table 3]

FIG. 4 shows a manufacturing wrestling in this embodiment. Sodium percarbonate and Emulgen PP-290
Are mixed in ethanol and dried to coat sodium percarbonate with Emulgen PP-290. Sodium thiosulfate and boric acid are mixed with this coded product, and the subtilisin A product name “ClearLens Pro 2.5 MG” as subtilisin is added, and after mixing, the product is obtained by packaging. It is a thing.

[0015]

EFFECT OF THE INVENTION The detergent of the present invention removes lipids and proteins with a percarbonate salt and proteolytic enzyme, improves the wettability to the lens with a surfactant, and weakens the liquidity with a neutralizer. Since it is alkaline, the oxygen permeable hard contact lens can be reliably cleaned. In addition, it is highly safe, and because it is granular, it is easy to handle and the washing operation is simple.

[Brief description of drawings]

FIG. 1 is a sectional view showing an example of coating.

FIG. 2 is a sectional view showing another example of coating.

FIG. 3 is a state diagram showing another example of coating.

FIG. 4 is a flow chart showing a manufacturing process.

[Explanation of symbols]

 1 inner layer 2 outer layer

Claims (4)

[Claims] 1. A cleaning agent for oxygen-permeable hard contact lenses, which is in the form of granules containing a percarbonate, a proteolytic enzyme, a surfactant and a neutralizing agent, and is dissolved in water before use. Agent. 2. The method according to claim 1, wherein at least one of the percarbonate and the proteolytic enzyme is in the form of granules coated with a water-soluble coating agent.
The cleaning agent for an oxygen-permeable hard contact lens described. 3. The percarbonate is sodium percarbonate, the proteolytic enzyme is subtilisin, the surfactant is a nonionic surfactant, and the neutralizing agent is thiosulfate and boric acid. The cleaning agent for an oxygen-permeable hard contact lens described. 4. The sodium percarbonate content is 0.1 to 5.0% and the subtilisin content is 0.00 when dissolved in water.
An oxygen-permeable cleaning agent for hard contact lenses, which is formulated to have a decomposed oxygen activity of 01 to 0.01 unit / ml.