JPH09192238A - Passive medicine feeder - Google Patents

Abstract

PROBLEM TO BE SOLVED: To administer all the quantity of a medicine without any manual operation which has possibility of causing contamination, by providing a cannula assembly insertedly attached to a socket, which has an inlet connected to a liquid medicine introduction connecting tube and an outlet connected to a liquid medicine feed connecting tube, and a medicine container so as to form a fluid path. SOLUTION: This passive medicine feeder is constituted of a socket 1, a cannula assembly 10, and a medicine cartridge 60 containing a medicine container 20 and the socket 1 is provided with an inlet 2 connected to a liquid introducing tube 61 and an outlet 3 connected to a drip syringe 62. The cannula assembly 10 is provided with an upper hollow tube 11 as an air path and a lower hollow tube 12 as a liquid introducing path, and a ring space 13 functioning as a mixed liquid medicine feeding path formed therein. The liquid medicine introducing path is composed of a lower chamber 6 and the lower hollow tube 12, the mixed liquid medicine feeding path is composed of the ring space 13 and an upper chamber 5, and the air path is composed of the upper hollow tube 11 and an air communication port 19, respectively so that the medicine can be fed without any obstruction in its flow.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a passive drug releasing device used as an administration set when a medical liquid or the like is put into a patient.

[0002]

2. Description of the Related Art An administration set, which is generally called an infusion and sometimes administers a dextrose solution, a saline solution or a solution containing water (hereinafter referred to as a medical solution) to a patient parenterally, is widely used. At this time, it is often practiced to mix and administer a specific drug with a medical liquid.

These administration sets generally consist of a container containing a large amount of medical liquid, a drip cylinder and a flow controller, and include a liquid filter, air removing means, an injection member for additionally mixing medicines and the like. A connecting pipe and a connecting means for the entrance and exit.

When a medical fluid mixed with a specific drug is supplied to a patient using such an administration set, when the drug is not liquid, it is preliminarily diluted and fluidized with a diluent or the like, and then the injection member in the set. It was supplied by mixing it with the medical fluid by injecting it into.

However, this method involves various risks of contamination because of the work of injecting the drug into the medical liquid and the preparatory work before it. Various measures have been taken to avoid these dangers and free medical personnel from work.

Among these devices, there are those represented by Japanese Patent Publication No. 5-81271 and Japanese Patent Publication No. 5-60758. In both methods, by placing a drug container (hereinafter referred to as drug container) such as a vial in which a drug is enclosed in a flow path of the medical liquid, the drug in the drug container is made liquid by passing the medical liquid through the drug container. Is to be derived.
Hereinafter, this method is referred to as a passive drug release method.

[0007] In this system, a socket and a cartridge to be coupled with the socket are prepared in order to install the inside of the medicine container in the flow path of the medical liquid in advance and set the medicine container and then replace it as necessary. I am trying to attach it.

According to this passive drug releasing method, if the drug container is set in the cartridge, there is no opportunity for the drug in the drug container to come into contact with the outside air, and all mixing operations are performed by the medical liquid, which is extremely safe. It is possible to secure the workability and save the work on site.

[0009]

However, such a conventional method is designed on the premise that all the constituent elements are maintained as they are once the medicine container is set and the use is started. It enables rapid drug injection while maintaining the IV drip rate, completes the full-dose administration without any manual operation that may cause contamination, and responds flexibly to smooth removal or replacement of the drug container, etc. It cannot be said that the above conditions are not necessarily satisfied. Accordingly, the present invention is directed to an improved passive drug release device that employs simple components while enjoying the benefits of the passive drug release system, and initiates a steady-state drug release quickly as needed. However, it is an object of the present invention to provide a tool that can easily suspend the release of a drug, replace the drug container, and put the entire amount of a drug without bothersome operations.

[0010]

SUMMARY OF THE INVENTION In one aspect, the passive drug releasing device of the present invention comprises a socket having an inlet connected to a medical liquid introduction connecting pipe and an outlet connected to a medical liquid outlet connecting pipe, and a drug container. And a socket and a cannula assembly that is pierced and attached to the drug container to form a fluid flow path, and a medical liquid introduction flow path for introducing the medical liquid into the drug container from the medical liquid introduction connecting pipe, and the drug container And a vent passage communicating with the atmosphere via the medicine container, and a medicine mixture solution discharge flow path for discharging the medicine mixture solution from the medicine container to the medical fluid discharge connecting pipe.

In a preferred embodiment of the present invention, the lower chamber and the first opening in the socket and the lower hollow tube of the cannula assembly extending from the upper portion of the drug container to the lower chamber of the socket in a piercing-mounted state of use. A configured medical fluid introduction flow path, an annular space formed around the lower cannula hollow tube in the lower portion of the cannula assembly and extending concentrically from the upper chamber in the socket to the upper drug container; A drug-mixed-solution discharge flow path formed by the second opening in the socket, and an upper hollow tube of the cannula assembly extending from the bottom of the drug container to near the center of the lower hollow tube in parallel with the lower hollow tube of the cannula. A ventilated passage formed by a small chamber having an atmospheric communication port provided with a hydrophobic filter, the small chamber being provided between the drug container and the upper chamber and communicating with the terminal end of the upper hollow tube. And wherein the door.

In the second embodiment of the present invention, the medical liquid introducing channel is provided in the upper chamber of the socket and the lower part of the cannula assembly extending from the bottom of the drug container to the lower chamber of the socket in the use state after being pierced. A hollow hollow tube formed around the hollow tube and extending concentrically from the upper chamber to the upper part of the drug container, and the drug mixed solution discharge flow channel is a lower hollow tube extending from the upper part of the drug container to the socket lower chamber. And the lower chamber, the air passage being an upper hollow tube formed along the central axis in the upper portion of the cannula assembly extending from the bottom of the drug container to the vicinity of the lower hollow tube, Consists of an upper hollow pipe having a lower hollow portion extending in parallel with the lower hollow pipe from the terminal end of the empty pipe to a small chamber having an atmosphere communication port provided between the drug container and the upper chamber, and the small chamber. Done .

In the third embodiment of the present invention, the medical liquid introducing channel is provided in the upper chamber of the socket and the central portion of the cannula assembly extending from the bottom of the drug container to the lower chamber of the socket in the state of being inserted and used. And a first space that extends like a tooth around the hollow tube of the cannula from the upper chamber to the upper portion of the drug container, and the drug mixed solution discharge flow path extends from the upper portion of the drug container to the socket lower chamber. A hollow space formed by a second space formed around the hollow tube in the central part of the chamber and a lower chamber, and the ventilation passage extends from the bottom of the drug container to a small chamber having an atmosphere communication port provided in the lower chamber. Each is composed of tubes.

In the fourth embodiment of the present invention, the medical liquid introducing passage is provided from the anterior chamber in the socket and the anterior chamber around the cannula hollow tube in the central part of the cannula assembly in the piercing-mounted state of use. A first space that extends like a tooth to the upper part of the drug container is formed, and the drug mixed solution discharge flow path is formed by a hollow cannula that extends from the bottom part of the drug container to the rear chamber of the socket, and the rear chamber, and the ventilation path is formed. A second portion formed around the hollow tube in a central portion of the cannula assembly extending in a tooth shape from an upper portion of the drug container to a small chamber having an atmosphere communication port provided between the drug container and the anterior chamber.
It is composed of a space and a small room.

In an embodiment of the present invention, the drug container and cannula assembly are integrated into a drug cartridge and mounted in a socket.

In another embodiment of the present invention, a medical liquid outlet provided at an end of a lower hollow tube extending from the lower chamber to an upper portion of the drug container and an end of an annular space extending from the upper portion of the drug container to the socket upper chamber. It is separated from the drug mixed solution inlet provided in the above-mentioned via the notch for the flow path provided separately.

In a further embodiment of the present invention, the chamber having an atmospheric communication port comprises a hydrophobic filter.

[0018]

BEST MODE FOR CARRYING OUT THE INVENTION Preferred embodiments of the present invention will be described below in detail with reference to the accompanying drawings. In the drawings, the same or similar components are designated by the same reference numerals or dashes.

FIG. 1 is an overall structural view showing an embodiment of the passive drug delivery device of the present invention. The release device of the present invention mainly comprises a drug cartridge 60 including a socket 1, a cannula assembly 10 and a drug container 20. It is a component.

[0020]

1 to 3 showing a first preferred embodiment of the present invention, a socket 1 has an inlet 2 connected to a medical liquid introducing tube 61 and an outlet 3 connected to a drip tube 62,
It constitutes a part of the medical liquid introduction flow path and the drug mixed solution discharge flow path.

The internal space of the socket 1 has a partition wall 4 and an upper chamber 5.
And lower chamber 6. The socket 1 has a holding portion 7 that holds the cannula assembly 10 on the upper portion thereof. The partition wall 4 connects the lower chamber 6 to the lower hollow tube 12 of the cannula assembly 10.
Has a first opening 8 communicating with the medical liquid inlet 16 and a second opening 8 ′ communicating the upper chamber 5 with the lower chamber 6. The holding part 7 and the opening 8 are provided so as to respectively maintain the sealing property with respect to the cannula assembly to be pierced. The cannula assembly 10 extending from the bottom portion (upper portion in FIG. 1) of the drug container 20 to the lower chamber 6 in the pierced state is an upper hollow tube 11 functioning as an air passage and a lower portion functioning as a medical fluid introduction flow path. The hollow tube 12 is formed, and the lower part of the cannula assembly is surrounded by the support tool 14 so as to form an annular space 13 that functions as a drug mixed solution outlet channel.

The upper hollow tube 11 has an inlet / outlet 9 at the upper end thereof, which acts as a gas inlet for air or the like when the medical liquid is introduced. The lower portion of the hollow tube 11 is integrated by a support tool 14 so as to extend in parallel with the lower hollow tube 12 and has an atmospheric communication having a hydrophobic filter provided between the drug container 20 and the socket 1 in the middle part of the support tool. It is in communication with the atmosphere via the mouth 19.

The lower hollow tube 12 has a medical liquid inlet 16 communicating with the lower chamber 6 at its lower end and a medical liquid outlet 18 communicating with a drug container 20 at its upper end. Lower hollow tube 1
An annular space 13 that functions as a drug mixed solution outlet channel is formed between the support 2 and the support 14 surrounding the outer periphery thereof, and the annular space 13 extends from the lower end of the support 14 to the middle part of the cannula assembly. The lower end of the annular space 13 communicates with the upper chamber 5 and acts as a drug mixed solution outlet 15,
The upper end of the container is in communication with the drug container 20 and the drug mixed solution inlet 1
Acts as 7.

2 and 3 are enlarged views showing details of the main parts of the cannula assembly 10 of the first preferred embodiment of the present invention. As shown in FIG. 2, the medical liquid outlet 18 from the lower hollow tube 12 to the drug container 20 is spaced apart from the drug mixed solution inlet 17 from the drug container 20 to the upper chamber 5 by a separate notch. Is provided. Further, as illustrated in FIG. 3, the gas inlet / outlet 9 provided at the upper end of the upper hollow tube 11 is composed of, for example, a large number of small holes, and the top of the tube is covered with a hat covering 360 degrees to prevent clogging. It is desirable to have

With the above-described structure and arrangement of the cannula assembly according to the present invention, there is no fear that the discharge of the mixed drug solution will be obstructed by the reflux of bubbles in the upper part (the lower part in FIG. 1) of the drug container 20 and the medical liquid. It has become possible to reliably eliminate mutual interference of liquid flows between the introduction flow channel and the drug mixed solution discharge flow channel. Therefore, in particular, at the start and end of the passive drug release operation, the steady flow of the liquid flow in the introduction channel and the outflow channel is promoted, and more stable passive drug release is guaranteed.

As can be understood from the above description, the medical liquid introduction flow path is constituted by the lower chamber 6 and the lower hollow tube 12, the drug mixed solution discharge flow path is constituted by the annular space 13 and the upper chamber 5, and the ventilation is performed. The passage is composed of an upper hollow tube 11 and an atmosphere communication port 19.

The dimensions of the medical liquid introduction flow path, the drug mixed solution discharge flow path, and the ventilation path are preferably as thin as possible from the viewpoint of operability so long as there is no practical problem. That is, it is desirable that the dimensions of the medical liquid introduction flow path, the drug mixed solution discharge flow path, and the ventilation path are 1.5 mm, 1.8-2 mm, and 0.6 mm, respectively.

The second embodiment of the present invention shown in FIG. 4 is substantially the same as the first embodiment except that the constitution of the cannula assembly 10 'and the medical fluid introducing passage and the drug mixture introducing passage are replaced. Are the same. Below, the description will be given mainly of the components different from those in FIG.

The cannula assembly 10 'extending from the bottom of the drug container 20 to the lower chamber 6 in the pierced state is an upper hollow tube 11' functioning as an air passage and a lower part functioning as a drug mixed solution outlet flow path. A hollow tube 12 'and a support 14' surround the middle portion of the cannula assembly and are configured to form an annular space 13 'which functions as a medical fluid introduction channel.

An upper hollow tube 11 'having a gas inlet / outlet 9'at its upper end is provided along the outer periphery of the support 14'.
It is connected to an atmosphere communication pipe which extends in parallel with 2'and communicates with an atmosphere communication port 19 'provided between the medicine container 20 and the socket 1 in the middle of the support.

The lower hollow tube 12 'has a lower chamber 6 at its lower end.
It has a drug mixture solution outlet 16 'which communicates with, and a drug mixture solution inlet 17' which communicates with the drug container 20 at its upper end. Supporting tool 1 surrounding the lower hollow tube 12 'and its outer circumference
An annular space 13 'that functions as a medical fluid introduction flow path is formed between the annular space 13' and 4 ', and the annular space 13' extends from the lower end of the support tool 14 'to the middle part of the cannula assembly. Annular space 1
The lower end of 3'communicates with the upper chamber 5 and acts as a medical fluid inlet 15 ', and the upper end of the annular space 13' communicates with the drug container 20 and acts as a medical fluid outlet 18 '.

As can be understood from the above description, the medical liquid introduction flow path is constituted by the upper chamber 5 and the annular space 13 ', and the drug mixed solution discharge flow path is constituted by the lower hollow tube 12' and the lower chamber 6. The ventilation path is composed of an upper hollow tube 11 'and an atmosphere communication tube having an atmosphere communication port 19'.

5 and 6 show a third embodiment of the present invention, which has the same basic structure and function as those of FIG. 4 except for the structure of the cannula assembly 30 and the atmosphere communication port 51. Therefore, the description will be given below mainly of the components different from those in FIG.

The socket 1 has a holding portion 7'for holding the middle portion of the cannula assembly 30 at its upper portion, and a holding portion 7 "for holding the lower portion of the cannula assembly 30 at its lower portion.

The cannula assembly 30 extending from the bottom (upper side in FIG. 5) of the drug container 20 to the ventilation chamber 50 provided at the bottom of the lower chamber 6 in the piercing-attached state is formed from the hollow tube 31 functioning as a ventilation passage. And is configured such that the support 34 surrounds the middle portion of the cannula assembly.

The hollow tube 31 has a gas inlet / outlet port 39 provided at its upper end portion and a gas inlet / outlet port 40 provided at its lower end portion, and constitutes a ventilation path for communicating gas from the inside of the drug container 20 through the atmosphere communication port 51. .

A hollow tube 31 and a supporting member 34 surrounding the outer circumference of the hollow tube 31.
And tooth-shaped spaces 32 and 33 functioning as a medical liquid introduction flow path and a drug mixed solution discharge flow path, respectively. The upper chamber 5 is provided in each of the middle part and the upper end part of the tooth space 32.
Further, an inlet 35 and an outlet 37 for the medical liquid which communicate with the medicine container 20 are provided, and an outlet 36 for the medicine mixture solution which communicates with the lower chamber 6 and the medicine container 20 is provided at the lower end and the upper end of the tooth-shaped space 33, respectively. And an inlet 38 is provided. Regarding the detailed shape and arrangement of the tooth spaces 32 and 33, for example, the configuration shown in FIG. 6 is desirable. However, it will be apparent to those skilled in the art that the configuration of the tooth space is not limited to this and many modifications are possible.

FIG. 7 showing the fourth embodiment of the present invention is the same as that of FIGS. 5 and 6 except for the operation of the cannula assembly and the socket and the arrangement of the drug container 20 and the atmosphere communication port 51 '. It has a structure and a function. Therefore, the description will be given below mainly of the components different from those in FIGS.

The internal space of the socket 1 is divided into a front chamber 5'and a rear chamber 6'by a partition wall 4 ', and each constitutes a part of the above-mentioned inlet passage and outlet passage. The socket 1 has a holding portion 7'for holding a cannula assembly 30 'at the lower part of its front chamber.
And 7 "and the septum 4'has an opening 8'for guiding the lower portion (upper portion in FIG. 7) of the cannula assembly 30 'into the rear chamber 6'.

The cannula assembly 30 'extending from the rear chamber 6'to the bottom of the drug container 20 in the pierced state is made up of a hollow tube 31' which functions as a drug mixed solution outlet channel, and is supported by a support tool 34 '. The middle portion of the cannula assembly is configured to be enclosed.

The hollow tube 31 'constitutes a drug mixture solution outlet passage having a drug mixture solution inlet 39' provided at its upper end and a drug mixture solution outlet 40 'provided at its lower end.

Support tool 3 surrounding the hollow tube 31 'and its outer circumference
Toothed spaces 32 'and 33' are formed between the toothed spaces 4'and 4 ', which function as an air passage and a medical liquid introduction passage, respectively. Atmosphere communication port 5 is provided in each of the middle and upper ends of the tooth space 32 '.
A gas inlet / outlet 35 ′ and an inlet / outlet 37 ′, which communicate with the atmosphere communication pipe having 1 ′ and the drug container, are provided, and the tooth-shaped space 3
The upper end and the lower end of 3'communicate with the drug container 20 and the anterior chamber 5 ', respectively.
6'is provided.

The operation of the first to fourth embodiments of the present invention will be described below with reference to FIGS.

In any of the embodiments, the drug container 20
Is used by being connected to the socket 1 in a state of being attached and pierced by the connecting needle, that is, the cannula assembly 10, 30. Depending on the capacity of the medical liquid container and the purpose of use during this connection, the medical liquid conduit following the drip tube is closed by a clamp as necessary. However, the device of the present invention does not cause any trouble even if it is connected without interruption of the medical liquid by the clamp.

When the device of the present invention is combined in the first and third embodiments of FIGS. 1 to 6, since the air passage is open to the atmosphere, the head difference between the medical liquid container and the drug container, that is, Due to the action of gravity, the medical liquid is more easily introduced into the drug container as compared with the conventional one, and the drug is rapidly dissolved. After that, by introducing medical liquid, the gas inlet / outlet port
The air passages are connected to the atmosphere communication ports 19, 19 ', 5 through 9', 39.
When it is filled up to 1, the air passage is cut off from the atmosphere by the medical liquid. At this point, the medical fluid introduction flow path is in complete communication, and the drug mixture solution is continuously administered to the patient at a predetermined rate by the action of keeping the upper space volume in the drip tube connected to the outlet 3 constant. . When the compressible fluid in the conduit, that is, the gas, expands and the pressure decreases as the patient administers the mixed drug solution, the negative pressure is automatically canceled to continuously consume the mixed drug solution. The medical fluid that replenishes is constantly introduced, and thus a predetermined steady infusion is realized.

Next, the drug mixture solution is purged, that is, the entire amount is administered or the drug container is replaced (sequential or combined administration).
The action of time will be described below. When a large-capacity medical liquid container is used, purging is started by closing the clamp provided between the medical liquid container and the socket. When the drip is continued with the clamp closed, the upper space of the drip tube becomes negative pressure, and the mixed drug solution is discharged so as to cancel it.As a result, the mixed solution in the ventilation channel is returned to the drug container. Since the air passage in the drug container is opened to the atmosphere, the mixed solution is completely released by spontaneous fall. When a small volume medical liquid container is used, the negative pressure of the drip cylinder, which similarly occurs when the drip is continued without using a clamp, is due to the action of residual air in the medical liquid container. Then, by releasing the air in the air passage in the drug container in the same manner as described above, the gravity of the drug mixed solution finally falls by gravity.

When the device of the present invention is combined in the fourth embodiment of FIG. 7, except that the drug container is in the normal position and the socket is divided into the front chamber 5'and the rear chamber 6 '. It shows the same operation as that of the third embodiment of FIG. Therefore, the operation different from that of the third embodiment will be mainly described. That is, the medical fluid is introduced into the drug container, which is released to the atmosphere by the binding, by gravity until the air passage is filled with the drug mixed solution, and then continuous steady administration is performed. In this state, the drug mixture solution discharged from the drug mixture solution discharge channel outlet 40 'is discharged upward in the completely liquid-tight channel into the rear chamber 6', and then downwards into the drip tube. It is made to fall. In purging the drug mixture solution, the residual drug mixture solution is finally pushed up by the action of the siphon principle formed between the hollow tube 31 'and the rear chamber 6'and then dropped into the drip cylinder. That is, also in the fourth embodiment, the drug mixed solution is the same as that of the first and third embodiments in that it naturally falls due to gravity, but it is different from the latter in that a liquid-tight siphon channel is interposed. different.

[0048]

According to the present invention, a rapid steady-state drug release is started without impairing the advantages of the passive drug release system, and the drug release can be interrupted, the drug container can be replaced, and the drug can be removed without troublesome operations. All doses can be added easily, and the effectiveness of the passive drug release system is surely improved as well as the substantial effect in preventing the defects that are often associated with the conventional passive drug release system. be able to.

[Brief description of the drawings]

FIG. 1 is an overall configuration diagram showing a first embodiment of the passive drug releasing device of the present invention.

2 is a partially enlarged cross-sectional view of the cannula assembly of FIG.

3 is a partially enlarged cross-sectional view of the cannula assembly of FIG.

FIG. 4 is an overall configuration diagram showing a second embodiment of the passive drug releasing device of the present invention.

FIG. 5 is an overall configuration diagram showing a third embodiment of the passive drug releasing device of the present invention.

6 is a partial enlarged cross-sectional view of the central portion of the cannula assembly of FIG.

FIG. 7 is an overall schematic diagram showing a fourth embodiment of the passive drug releasing device of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Socket 7 Holding part 10 Cannula assembly 13 Annular space 14 Support tool 20 Drug container 60 Drug cartridge

Claims (8)

[Claims] 1. A socket having an inlet connected to a medical liquid introduction connecting pipe and an outlet connected to a medical liquid outlet connecting pipe, a drug container, and a fluid flow path pierced and attached to the socket and the drug container. A passive drug releasing device for releasing the drug in the drug container into the medical liquid, the device comprising a cannula assembly forming a medical device, the medical liquid introducing the medical liquid from the medical liquid introducing pipe into the drug container. A passive drug releasing device comprising a liquid introducing flow path, a drug mixed solution discharge flow path for discharging a drug mixed solution from the drug container to the medical liquid discharge connecting pipe, and a ventilation path communicating with the atmosphere through the drug container. . 2. The device according to claim 1, wherein the drug container and the cannula assembly are integrated as a drug cartridge and attached to the socket. 3. A lower chamber and a first opening in the socket,
A medical liquid introduction flow path constituted by a lower hollow tube of the cannula assembly extending from the upper portion of the drug container to the lower chamber of the socket in a state of being attached by piercing, and the cannula in a lower portion of the cannula assembly. Discharge of a mixed solution that is formed around a lower hollow tube and that is formed by an annular space that extends concentrically from the upper chamber in the socket to the upper portion of the drug container, and a second opening in the upper chamber and the socket. A flow channel, an upper hollow tube of the cannula assembly extending from the bottom of the drug container to near the center of the lower hollow tube in parallel with the lower hollow tube of the cannula, and between the drug container and the upper chamber. The ventilation passage formed by a small chamber having an atmosphere communication port, the ventilation passage being provided at the end of the upper hollow pipe and communicating with the end portion of the upper hollow pipe. 4. A medical liquid outlet provided at an end of the lower hollow tube extending from the lower chamber to the upper part of the drug container and at an end of the annular space extending from the upper part of the drug container to the socket upper chamber. The device according to claim 3, wherein the mixed solution inlets are spaced apart from each other by a channel notch provided separately. 5. The device of claim 3, wherein the chamber having the atmosphere communication port comprises a hydrophobic filter. 6. An upper chamber in the socket and a lower hollow tube of the cannula assembly extending from a bottom of the drug container to a lower chamber in the socket in a piercing-mounted state of use. A medical liquid introduction flow path formed by an annular space extending concentrically from the upper chamber to the upper part of the drug container, the lower hollow tube extending from the upper part of the drug container to the socket lower chamber, and the lower chamber A drug-mixed-solution discharge flow path formed by: and an upper hollow tube formed along a central axis in an upper portion of the cannula assembly extending from the bottom of the drug container to the vicinity of the lower hollow tube. An upper hollow tube having a lower hollow portion extending in parallel with the lower hollow tube from a terminal end of the upper hollow tube to a small chamber having an atmosphere communication port provided between the drug container and the upper chamber And the small room And a formed air passage, the instrument of claim 1. 7. Around the cannula hollow tube in the upper chamber of the socket and in the central portion of the cannula assembly extending from the drug container bottom to the lower chamber in the socket in the pierced and mounted state of use. In the central part of the cannula assembly, which extends from the upper chamber to the upper part of the drug container and has a tooth-shaped first space, and a medical liquid introduction channel, and from the upper part of the drug container to the lower chamber of the socket. A second space formed around the hollow tube, a drug mixed solution discharge flow path formed by the lower chamber, and a bottom extending from the drug container to a small chamber having an atmosphere communication port provided in the lower chamber. The device of claim 1 including the vent passage defined by the hollow cannula tube. 8. An anterior chamber within the socket and a toothed extension about the anterior chamber from the anterior chamber to an upper portion of the drug container around a hollow cannula tube in a central portion of the cannula assembly in a piercing and mounted state of use. A medical fluid introduction flow constituted by a first space; a cannula hollow tube extending from the bottom of the medicine container to a rear chamber of the socket; and a medicine mixed solution discharge flow passage constituted by the rear chamber, A second portion formed around the hollow tube in a central portion of the cannula assembly extending in a tooth shape from an upper portion of the medicine container to a small chamber having an air communication opening provided between the medicine container and the front chamber. The device according to claim 1, comprising a space and a ventilation path formed by the small chamber.