JPH08266640A - Passive medicine discharge appliance - Google Patents

Abstract

PURPOSE: To prevent remains of a medicine in a medicine vessel by dividing an upper chamber to pass a medical liquid to be sent into the medicine vessel and a lower chamber to pass a medical liquid in which a chemical is dissolved or mixed by a dividing plate, and arranging a communicating hole of the upper and lower chambers in the dividing plate. CONSTITUTION: A dividing plate 14 is arranged inside a socket positioned between a medicine vessel and an air chamber, and the inside of the socket is divided into an upper chamber 17 and a lower chamber 18. A through hole 15 is arranged in the dividing plate 14. A cartridge is installed in the socket 2, and an upper port 28 of a cannula 27 is positioned in the medicine vessel, and a lower port 29 is positioned in the lower chamber 18 through the through hole 15. Therefore, a medical liquid enters the upper chamber 17 by passing through a socket inlet 11 from a medical liquid vessel, and also enters the medicine vessel of the cartridge by passing through a cavity 34 outside of the cannular 27, and contacts with a medicine. It rises inside of the medicine vessel, and soon enters the lower chamber 18 by passing through the inside of the cannula 27 from the upper port 28 of the cannula 27, and drips out of a socket outlet 12.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a passive drug releasing device for use in an administration set used for administering a medical liquid or the like to a patient.

[0002]

2. Description of the Related Art Generally, an infusion set, which is generally referred to as an infusion solution and sometimes administers a dextrose solution, a saline solution, or a solution containing water (hereinafter referred to as a medical solution) to a patient parenterally, is widely used. At this time, it is often practiced to mix a specific drug with a medical liquid or the like and administer it. These administration sets are generally composed of a container containing a large amount of medical liquid, a drip cylinder and a flow controller, a liquid filter, an air removing means, an injection member for additionally mixing a drug, etc. In addition, it has the necessary connecting pipes and connecting means for the entrance and exit. When supplying a medical fluid mixed with a specific drug to a patient using such an administration set, when the drug is not liquid, it is diluted and fluidized beforehand with a diluent etc. As it was, it was transferred to a syringe, then inserted into the injection member in the set and injected, mixed with the medical liquid and supplied.

However, this method involves various risks of contamination due to the work of injecting a drug into a medical liquid and the preparatory work before the work. Various measures have been taken to avoid this danger and free medical personnel from work. Some of these ideas are represented by Japanese Examined Patent Publication No. 5-81271 and Japanese Examined Patent Publication No. 60758. Both of them place a drug container (hereinafter referred to as drug container) such as a vial in which the drug is enclosed in the flow path of the medical liquid so that the medical liquid passes through the drug container and the drug in the drug container is liquefied and carried away. It is a method to let. Hereinafter, this method is referred to as a passive drug release method. In this system, in order to incorporate the inside of the drug container into the liquid flow path of the medical liquid in advance, and to set the drug container, and prepare a socket and a cartridge to be coupled with the socket for exchanging as necessary, the cartridge is It comes with a drug container.

According to this passive drug releasing method, when the drug container is set in the cartridge, there is no opportunity for the drug in the drug container to come into contact with the outside air, and all mixing operations are performed by the medical liquid, which is extremely high. The safety can be ensured and the work on site can be omitted. However, of course, drug infusion occurs under strictly controlled conditions. Therefore, the injection amount of the drug, the concentration at the time of injection,
The injection time and the like are preferably performed as planned. In this case, in the passive drug release system, these conditions are often determined by the release state of the drug into the medical liquid. In particular, it is necessary to use the entire amount of the drug in the drug container. It is not preferable that part of the drug in the drug container remains in the drug container or is significantly unevenly released.

[0005]

SUMMARY OF THE INVENTION The present invention employs a passive drug release system in which there is generally no problem in a certain type of passive drug release system, but in some cases it may occur depending on conditions. The present invention provides a passive drug releasing device that completely removes a part of the drug remaining.

[0006]

The present invention includes: The medical liquid is passed through the drug container to release the drug into the medical liquid, the cannula is inserted into the drug container, and the medical liquid is introduced into the drug container from a position near the outside of the cannula, In a passive drug-releasing device of a type in which a medical liquid in which a drug is dissolved or mixed from the vicinity of the tip of the cannula is discharged to the outside of a drug container, an upper chamber through which the medical liquid sent to the drug container passes and a drug are dissolved. Alternatively, a passive chamber characterized by having a lower chamber through which a mixed medical liquid passes, a dividing plate for separating the upper chamber and the lower chamber, and a small hole for communicating the upper chamber and the lower chamber in the dividing plate. Drug release device. 2. 2. The passive drug releasing device as described in 1 above, wherein a small hole that communicates the upper chamber and the lower chamber is provided in a dividing plate that separates the upper chamber and the lower chamber, at a substantially central portion of the dividing plate. 3. It is characterized in that a dividing plate which separates the upper chamber and the lower chamber is provided with a small hole for communicating the upper chamber and the lower chamber along a hole for other purposes provided in the dividing plate. The passive drug releasing device according to 1 above.

4. The medical liquid is passed through the drug container to release the drug into the medical liquid, the cannula is inserted into the drug container, and the medical liquid is introduced into the drug container from a position near the outside of the cannula, The method in which the medical liquid in which the drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container has an inlet connected to the medical liquid container, an outlet for the medical liquid mixed with the drug, and a dividing plate, and The upper chamber to be formed is provided with a cartridge mounting portion, the dividing plate has a socket having a through hole closed by a cannula, and the elastic portion provided in the cartridge mounting portion is pierced and fixed with the cannula. Close the through hole of the dividing plate, attach the drug container to the other end of the cannula, insert the cannula into the drug container, and connect the medical fluid to the outside of the cannula at the fixed part with the cartridge of the cannula. Are those in which a thin gap for, faces the lower chamber above that through the through hole of the division plate of the cannula is divided by the dividing plate,
The passive drug releasing device as described in 1 above, 2 or 3 above, wherein the cartridge is removable. By doing so, the purpose is achieved.

A detailed description will be given below with reference to the drawings. 1 to 4 show an example of a passive drug releasing system in which the present invention is used, and FIGS. 5 and 6 are schematic views of the essential parts to which the present invention is added. FIG. 1 shows the overall construction of an example of a passive drug release system in which the present invention is used. In FIG. 1, reference numeral 1 is a medical liquid container containing a medical liquid. 2 is a socket, 3 is an air chamber, 4 is a flow rate controller, 5 is an upper plug, and 6 is a lower plug. The respective members are basically connected by a connecting pipe. In the illustrated one, the medical fluid container 1 and the entire system are connected by the upper insertion tool 5, and the intravenous injection needle 9 or the like is connected to the lower insertion tool 6 to connect the system to the patient. Further, although the socket 2 and the air chamber 3 are directly connected as shown in the drawing, it is not particularly limited whether they are directly connected or connected by using a connecting pipe.

Since what is shown is directly connected, the droplet outlet 7 is located at the outlet of the socket 2 and thus at the inlet of the air chamber 3. A screen 8 is provided in the air chamber 3 to take out inappropriate contaminants from the liquid passing therethrough and prevent them from being injected into the body. The screen 8 also does not necessarily have to be provided in the air chamber 3. An independent filtering tool may be provided in the system by using a connecting pipe, or may be provided inside the socket 2 and above the droplet outlet 7. Further, 10 is an injection site provided in the system as required, and is used when it is inevitable to inject a special drug into a medical fluid by using a syringe or a connecting tube connecting another medical fluid. A cartridge described later is connected to the socket 2 to form a set for performing a passive drug release method.

FIG. 2 is a front sectional view showing the inside of an example of the socket. The socket 2 has a socket inlet 11 at one end and a socket outlet 12 at the other end. The socket inlet 11 is connected to the upper insertion tool 5 using a connecting pipe, and is connected to the medical liquid container 1. The socket outlet 12 is connected to the air chamber 3. The socket outlet 12 is provided with the droplet outlet 7. If the socket outlet 12 is not directly connected to the air chamber 3, the droplet outlet 7 is provided at the inlet of the air chamber connected to the socket outlet 12 using a connecting pipe. The split plate 1 is inside the socket 2.
4 is provided to divide the socket into an upper chamber 17 and a lower chamber 18. Further, the division plate 14 is provided with a through hole 15.

The portion of the dividing plate 14 including the through hole 15 has elasticity, and when a rod-shaped member having a diameter larger than the diameter of the through hole is inserted into the through hole 15, this is received. Of course, all of the dividing plates 14 may be elastic, that is, made of rubber-like material. Further, the socket 2 is provided with a cartridge mounting portion 16.
The mounting portion 16 is made of an elastic material capable of piercing and holding a needle-shaped object. As such, the cartridge mounting portion 16 closes the upper chamber 17. The through hole 15 of the dividing plate is the cartridge mounting portion 16
It is located directly below.

FIG. 3 is a front sectional view of an example of the cartridge. The cartridge 20 shown in FIG. 3 shows a state before being mounted in the socket 2. The cartridge 20 has an adapter 21. The adapter 21 holds the cannula 27 on the lower side and mounts the drug container 22 on the upper side. The adapter 21 has a support horizontal plate 30 on the lower inside.
The supporting horizontal plate 30 is provided with a holding tube 31 inside thereof. The cannula 27 is supported inside the holding tube 31. A thin gap is provided between the inner wall of the holding tube 31 and the outside of the cannula 27 in the direction in which the cannula extends, that is, in the vertical direction. That is, assuming that the cannula 27 is the axle of the vehicle, the retaining tube 31 exists in a state like a wheel of a vehicle, and a thin plate radially extends in the vertical direction in a cross section between the retaining tube 31 and the cannula 27. There is a thin gap 34 that extends vertically between the thin plates.

The cannula 27 is fixed by a holding tube 31, is composed of a thin hollow tube, and has an upper opening 28 and a lower opening 2.
9 is open. Reference numeral 33 denotes a protective portion fixed to the cannula 27, which is located above the holding portion of the cannula 27 that is held by the holding tube 31. The protector 33 is located outside the cannula 27, is wound around the cannula 27, and has a distance from the upper end of the holding tube 31. That is, the protection portion 33 is provided so as not to close the narrow gap 34 between the holding tube 31 and the cannula 27. Reference numeral 32 denotes a lower cover that protects the vicinity of the lower opening 29 of the cannula 27, which can be removed at the time of use. The adapter 21 near the outside of the lower cover 32
In order to easily attach the entire cartridge to the socket 2, the concave and convex portions are provided so as to be engaged with the opposite sections of the socket.

In FIG. 3, reference numeral 24 is a stopper, for example, a rubber stopper, which is made of a soft material for keeping the airtightness of the medicine container 22 and a material which is easily torn off, and 25 is for caulking the rubber stopper 24. A thin metal cap, such as an aluminum cap. The rubber stopper 24 is tightly fitted to the medicine container 22, and when the medicine container 22 is pushed downward, the rubber stopper 24 can move downward in the adapter 21. An upper cover 26 is attached to the adapter 21 so that the medicine container cannot be pushed down carelessly. In order to push down the drug container 22, first, the upper cover 26 is removed from the adapter 21, and then the drug container 22 is pushed down. The upper opening 28 of the cannula 27 faces a close position below the stopper 24.

FIG. 4 shows the cartridge 2 of FIGS. 2 and 3.
The state where 0 is incorporated in the socket 2, that is, the use state is shown. For installation, first the upper cover 26 of the cartridge 20 is removed and the drug container 22 is pushed down.
At this time, the upper mouth 28 of the cannula penetrates the rubber stopper 24 and the thin metal band 25 and enters the medicine container 22. When the medicine container 22 is further pushed down, even the protective portion 33 of the cannula 27 enters the medicine container 22 beyond the rubber stopper 24 and the thin metal band 25. There is a gap between the upper end of the holding tube 31 of the cannula and the protection part 33, and the drug container 22 is pushed down until this part is also located in the drug container 22. Then, the lower cover 32 also hits the medicine container 22 and is pushed down, and can be easily removed from the adapter 21.

Next, the lower cover 32 of the cartridge 20.
Of the cannula 27 so that the lower opening 29 of the cannula 27 faces the cartridge mounting portion 16 of the socket 2.
Pierce through. When the cartridge is further pushed down, the lower opening 29 of the cannula is exposed to the through hole 15 of the dividing plate 14, and is pushed and expanded to penetrate downward. At this time, the lower end of the holding tube 31 is inside the upper chamber 17, and the through hole is closed between the upper chamber 17 and the lower chamber 18 by the cannula 27 so that the direct communication passage is lost.

FIG. 5 and FIG. 6 schematically show the main parts to which the present invention is added. First, the situation of passive drug release will be described with reference to FIG. Before attaching the cartridge 20 to the socket 2, the medical liquid reaches the socket inlet 11 of the socket 2 from the medical liquid container 1 and enters the upper chamber 17.
Then, it enters the lower chamber 18 through the through hole 15 of the dividing plate 14.
Further, at the socket outlet 12 of the lower chamber 18, the droplet outlet 7
Is provided, the medical liquid drips from the liquid droplet outlet 7. Next, when the cartridge 20 is attached to the socket 2, the through hole 15 of the upper chamber 17 is closed by the cannula 27, so that the medical liquid passes through the narrow gap 34 formed by the outside of the cannula 27 and the inside of the holding tube 31. , Enters the lower portion of the medicine container 22 from the upper end of the holding tube 31. There, the medical fluid comes into contact with the drug.

Here, the medical liquid generally dissolves the drug, but may be simply mixed. In any case, the medical liquid and the drug are agitated to be in a sufficiently diffused state. The medical liquid gradually rises in the medicine container 22 while being dissolved or mixed, finally reaches the upper opening 28 of the cannula, enters the cannula 27 from there, and flows downward in the cannula 27 to enter the lower chamber 18. . Therefore, the lower chamber 18 contains the medical liquid containing the drug. In the case shown in the figure, the socket outlet 12 of the lower chamber 18 is provided with the droplet outlet 7, so that the medical liquid containing the medicine drips from the droplet outlet 7.

Inside the drug container 22, a cannula 27
As the medical liquid containing the drug flows downward through the cannula 27 from the upper mouth 28, the internal pressure of the drug container 22 becomes a slight negative pressure, so that the medical liquid is sucked up through the void 34 and the drug is absorbed. The liquid is introduced into the container 22 and the upper surface 28 of the cannula 27 keeps the liquid level. Medical fluid gradually leaks out,
The position of the head passes through the medical liquid container 1, reaches the socket inlet 11 of the socket 2, and enters the upper chamber 17. Further, when reaching the lower end of the holding tube 31 contained in the upper chamber 17, the medical liquid does not flow into the drug container 22. If left as it is, the medical liquid will remain mainly in the medicine container 22 and in the upper chamber 17 of the socket, with some medicine.

To avoid residue, it is necessary to remove the cannula 27 from the through hole 15. That is, for this purpose, it is necessary to pull up the cannula 27 together with the medicine container 22. When the through hole 15 is first opened by lifting, the medical liquid in the upper chamber 17 flows out to the lower chamber 18. During this period, the medical liquid having a slight medicinal component is passed through the narrow space 34 between the holding tube 31 and the cannula 27 and is dropped into the lower chamber 18 through the upper chamber 17 and the socket outlet 12 Get out of. As a result, the last condition may not be a smooth termination, as the presence of the drug is interrupted or re-existed when trying to avoid residue. Depending on the type of drug and the quality and amount of medical fluid, it may be less preferable.

The above description is an example of a passive drug release system. In the above description, the socket and the cartridge are separate bodies, and further, the cartridge is such that the drug container can be moved in the adapter. However, the method of utilizing the present invention is not limited to the one described. That is, the fact that the socket and the cartridge are separate bodies and that the drug container can be moved in the adapter has nothing to do with whether the method of the present invention can be used. The point is that a cannula is inserted into the drug container, and the medical liquid passes near the outside of the cannula and enters the drug container to come into contact with the drug and agitate and dissolve, sometimes with agitation and mixing, and provided on the upper part of the cannula. If it is discharged from the upper mouth, it can be used as a passive drug release system. Furthermore, it is complete if the medical liquid has a flow path that does not come into contact with the medical liquid before and after entering the drug container under normal use. Other than that is not a condition for using the present invention.

Therefore, in the present invention, a small hole is provided in the division plate 14 provided in the socket 2. In FIG. 5, the small hole 35 is provided at a substantially central portion of the dividing plate. Small hole 3
6 is provided in the immediate vicinity along the through hole 15 provided in the dividing plate 14. Generally, the small holes 35 and the small holes 36 may be selectively provided. However, it does not refuse to provide two small holes in one dividing plate. By providing a small hole in the dividing plate, there is substantially no fear that the medical liquid will remain with the drug in the drug container 22.

Even if the small holes 35 or 36 exist, the liquid is moved in the same manner as the conventional one until the amount of the medical liquid decreases and the medical liquid entering the medicine container 22 from the upper chamber 17 is exhausted. When the amount of the medical liquid decreases and the medical liquid does not enter the medicine container 22 through the upper chamber 17, the flow of the liquid becomes different from the conventional one. That is, when the medical liquid travels from the upper chamber 17 to the drug container 22, the air in the drug container initially pushed by the inflowing medical liquid passes through the cannula 27 to the lower chamber 18,
A gas-liquid interface is formed by the small holes 35 or 36. However, by selecting the size of the small holes 35 or 36, the medical liquid that has entered the upper chamber 17 does not enter the lower chamber 18 through the small holes. That is, a gas-liquid interface is formed through the small holes 35 or 36, and the medical liquid does not drop into the lower chamber 18 due to the surface tension of the gas-liquid interface. This state is maintained while the medical liquid enters the medicine container and descends together with the medicine, that is, on the bottom surface of the upper chamber 17, that is, on the dividing plate 14, in the small hole 35.
Or continue as long as the vicinity of 36 is wet with the medical liquid.

When a predetermined amount of the medical liquid flows, the communication passage from the medical liquid container 1 to the socket 2 becomes empty, and then the liquid level in the upper chamber 17 also drops. Then, the inflow of the medical liquid into the drug container 22 from the liquid inlet side of the holding tube 31 in the upper chamber 17 is also stopped, so that the liquid does not flow through the upper port 28. At this time, the balance of the gas-liquid interface is lost, and the medical liquid begins to enter the lower chamber 18 through the small holes 35 or 36. First, the upper chamber 1
The medical liquid existing in 7 moves to the lower chamber 18. As a result, the force for sending the medical liquid from the upper chamber into the drug container is lost, so that the medical liquid in the drug container is dissolved in or mixed with the drug, and the route through which the medical liquid has been sent is reversed to the upper chamber 17
Return to the inside, mix with the medical liquid there, small hole 3
It is sent to the lower chamber 18 via 5 or 36. Therefore, the residual liquid in the drug container is reduced to the extent that it is considered to be substantially absent. In this case, all the residual liquid and the medicine are discharged without any modification to the cartridge.

If the small hole is located at a position where a medical liquid not yet in contact with the drug exists and passes through, and a passage for the medical liquid in which the drug is dissolved or mixed and which contacts the drug and passes therethrough. Good. In FIG. 5, it is provided substantially at the center of the dividing plate, and in FIG. 6, it is provided along the through hole 15. The point is that it only needs to be in a position that separates the part where the medical liquid not yet in contact with the drug exists and the part that passes and the passage of the medical liquid in contact with the drug that dissolves or mixes the drug. It may be vertical or vertical, and the upper chamber or the lower chamber may have a tubular shape and the small holes may be provided to connect them. It can be selected as appropriate in consideration of ease of processing, accuracy of operation, and the like.

It should be noted in the present invention that if the small holes 35 or 36 are provided, all the medical liquid and the residual liquid of the medicine can be treated in a normal state without any operation on other parts. It is possible to discharge after that, and it is possible to send a prescribed amount of medicine in a continuous state.

[0027]

INDUSTRIAL APPLICABILITY The present invention relates to a passive drug releasing system in which a cannula is substantially inserted into a drug container and a medical liquid is introduced along the outside of the cannula. , The medical liquid before being sent to the medicine container and the medicine in the medicine container are provided by adjoining the lower chamber through which the medicine is dissolved or mixed and passing through the medicine, and by providing a small hole in the dividing plate for separating the two. A substance that can have a very substantial effect of preventing the liquid and the drug from remaining, and is likely to be a defect of the passive drug release method without any special operation. It is possible to increase the advantages of the passive drug release system more reliably.

[0028]

[Brief description of drawings]

FIG. 1 is an overall configuration diagram showing an example of a passive drug release system in which the present invention is used.

FIG. 2 is a front sectional view of an example of a socket when the present invention is also used.

FIG. 3 is a front sectional view of an example of a cartridge when the present invention is also used.

FIG. 4 is a front sectional view showing an example of a usage state when the present invention is also used.

FIG. 5 is a schematic diagram of the present invention.

FIG. 6 is a schematic view of the present invention in an embodiment different from that of FIG.

[0029]

[Explanation of symbols]

 1: Medical liquid container 2: Socket 3: Air chamber 4: Flow controller 5: Upper insertion tool 6: Lower insertion tool 7: Droplet outlet 8: Screen 9: IV needle 10: Injection site 11: Socket inlet 12: Socket outlet 14: Dividing plate 15: Through hole 16: Cartridge mounting part 17: Upper chamber 18: Lower chamber 20: Cartridge 21: Adapter 22: Drug container 23: Drug 24: Rubber stopper 25: Metal cap 26: Upper cover 27: Cannula 28: Cannula upper port 29: Cannula lower port 30: Support lateral plate 31: Holding tube 32: Lower cover 33: Protective part 34: Void between holding tube and cannula 35: Small hole 36: Small hole

Claims (4)

[Claims] 1. A medical fluid is passed through a drug container to release the drug into the medical fluid. A cannula is inserted into the drug container, and the medical fluid is supplied from a position near the outside of the cannula. In a passive drug-releasing device in which a medical liquid in which a drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container, an upper chamber through which the medical liquid sent to the drug container passes. And a lower chamber through which a medical liquid in which a drug is dissolved or mixed passes, a dividing plate that separates the upper chamber and the lower chamber is provided, and a small hole that connects the upper chamber and the lower chamber is provided in the dividing plate. A passive drug releasing device characterized by: 2. A division plate for partitioning the upper chamber and the lower chamber, and a small hole for communicating the upper chamber and the lower chamber is provided at a substantially central portion of the division plate. Passive drug release device. 3. A dividing plate which divides the upper chamber and the lower chamber is provided with a small hole for communicating the upper chamber and the lower chamber along a hole for other purposes provided in the dividing plate. The passive drug releasing device according to claim 1, wherein the device is a passive drug releasing device. 4. A medical fluid is passed through a drug container to release the drug into the medical fluid. A cannula is inserted into the drug container, and the medical fluid is supplied from a position near the outside of the cannula. A method in which a medical liquid in which a drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container has an inlet connected to the medical liquid container, an outlet for the medical liquid mixed with the drug, and a dividing plate. A cartridge mounting portion is provided in the upper chamber formed by the holding plate, the socket having a through hole closed by a cannula in the dividing plate, and the elastic portion provided in the cartridge mounting portion is pierced with the cannula and fixed. , Close the through-hole of the dividing plate under the cannula, attach the drug container to the other end of the cannula, insert the cannula into the drug container, and attach the cannula to the cartridge fixing part. It has a narrow space for passage of medical liquid, and the tip of the through-hole of the split plate of the cannula faces the lower chamber divided by the split plate, and the cartridge is removable. Claim 1 characterized by
Alternatively, the passive drug releasing device according to claim 2 or claim 3.