JPH08266639A - Passive medicine discharge appliance - Google Patents

Abstract

PURPOSE: To perfectly prevent remains of a medicine in a medicine vessel by arranging a small hole to communicate the inside and the outside of a cannula in a lower position of the cannula existing in the medicine vessel. CONSTITUTION: In a medicine vessel 22, a small hole 35 or a small hole 36 is arranged in a lower part of a cannula 27. That is, the small hole 36 is arranged under a protective part 33 of the cannula 27 as well as above a holding tube 31. The small hole 35 is arranged just above the protective part 33 of the cannula 27. The small holes 35 and 36 may be generally and alternatively arranged, but both of two may be arranged. Therefore, a medical liquid in the medicine vessel 22 doe not remain while having a medicine as it is. Even if the small holes 35 and 36 are arranged, the same liquid is moved until the medical liquid reduces and the medical liquid entering the medicine vessel 22 from an upper chamber 17 runs out. When the medical liquid entering the medicine vessel 22 runs out, a liquid advances into the cannula 27 through the small hole 35 or the small hole 36, and a mixture of the medicine and the medical liquid in the medicine vessel 22 moves downward.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a passive drug-releasing device for use in an administration set used for administering a medical liquid or the like to a patient.

[0002]

2. Description of the Related Art Generally, an infusion set, which is generally referred to as an infusion solution and sometimes administers a dextrose solution, a saline solution, or a solution containing water (hereinafter referred to as a medical solution) to a patient parenterally, is widely used. At this time, it is often practiced to mix a specific drug with a medical liquid or the like and administer it. These administration sets are generally composed of a container containing a large amount of medical liquid, a drip cylinder and a flow controller, a liquid filter, an air removing means, an injection member for additionally mixing a drug, etc. In addition, it has the necessary connecting pipes and connecting means for the entrance and exit. When supplying a medical fluid mixed with a specific drug to a patient using such an administration set, when the drug is not liquid, it is diluted and fluidized beforehand with a diluent etc. As it was, it was transferred to a syringe, then inserted into the injection member in the set and injected, mixed with the medical liquid and supplied.

However, this method involves various risks of contamination due to the work of injecting a drug into a medical liquid and the preparatory work before the work. Various measures have been taken to avoid this danger and free medical personnel from work. Some of these ideas are represented by Japanese Examined Patent Publication No. 5-81271 and Japanese Examined Patent Publication No. 60758. Both of them place a drug container (hereinafter referred to as drug container) such as a vial in which the drug is enclosed in the flow path of the medical liquid so that the medical liquid passes through the drug container and the drug in the drug container is liquefied and carried away. It is a method to let. Hereinafter, this method is referred to as a passive drug release method. In this system, in order to incorporate the inside of the drug container into the liquid flow path of the medical liquid in advance, and to set the drug container, and prepare a socket and a cartridge to be coupled with the socket for exchanging as necessary, the cartridge is It comes with a drug container.

According to this passive drug releasing method, when the drug container is set in the cartridge, there is no opportunity for the drug in the drug container to come into contact with the outside air, and all mixing operations are performed by the medical liquid, which is extremely high. The safety can be ensured and the work on site can be omitted. However, of course, drug infusion occurs under strictly controlled conditions. Therefore, the injection amount of the drug, the concentration at the time of injection,
The injection time and the like are preferably performed as planned. In this case, in the passive drug release system, these conditions are often determined by the release state of the drug into the medical liquid. In particular, it is necessary to use the entire amount of the drug in the drug container. It is not preferable that part of the drug in the drug container remains in the drug container or is significantly unevenly released.

[0005]

SUMMARY OF THE INVENTION The present invention employs a passive drug release system that generally does not present any problem in some form of passive drug release system, but sometimes in a drug container that can occur under certain conditions. It is intended to provide a passive drug-releasing device that completely removes a part of the drug remaining.

[0006]

The present invention includes: The medical liquid is passed through the drug container to release the drug into the medical liquid, the cannula is inserted into the drug container, and the medical liquid is introduced into the drug container from a position near the outside of the cannula, In a passive drug-releasing device in which a medical liquid in which a drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container, a small hole communicating with the inside and outside of the cannula is provided at a position below the cannula in the drug container. A passive drug delivery device characterized by being provided. 2. The small hole communicating between the inside and the outside of the cannula is located near the end point of a narrow gap for introducing a medical liquid into the drug container, which is arranged concentrically with the cannula along the outside of the cannula. The passive drug releaser described. 3. The passive hole according to claim 1, wherein the small hole communicating between the inside and the outside of the cannula is located near an upper end of a protective portion provided below the cannula for protecting the cannula when inserting the cannula into the drug container. Drug releaser.

4. The medical liquid is passed through the drug container to release the drug into the medical liquid, the cannula is inserted into the drug container, and the medical liquid is introduced into the drug container from a position near the outside of the cannula, The method in which the medical liquid in which the drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container has an inlet connected to the medical liquid container, an outlet for the medical liquid mixed with the drug, and a dividing plate, and The upper chamber to be formed is provided with a cartridge mounting portion, the dividing plate has a socket having a through hole closed by a cannula, and the elastic portion provided in the cartridge mounting portion is pierced and fixed with the cannula. The through hole of the split plate is closed, and the tip of the through hole of the split plate of the cannula faces the lower chamber formed by the split plate.A drug container is attached to the other end of the cannula, and the cannula is attached. The above-mentioned 1 or 2 is characterized in that it is inserted into a medicine container, and a narrow space for passage of a medical liquid is provided on the outside of the cannula at a fixed portion of the cannula with the cartridge, and the cartridge is removable. The passive drug-releasing device according to 2 or 3 above. By doing so, the purpose is achieved.

A detailed description will be given below with reference to the drawings. 1 to 4 show an example of a passive drug releasing method in which the present invention is used, and FIG. 5 is a schematic view of a main part to which the present invention is added. FIG. 1 shows the overall construction of an example of a passive drug release system in which the present invention is used. In FIG. 1, reference numeral 1 is a medical liquid container containing a medical liquid. 2 is a socket, 3 is an air chamber, 4 is a flow rate controller, 5 is an upper plug, and 6 is a lower plug. The respective members are basically connected by a connecting pipe. In the illustrated one, the medical fluid container 1 and the whole system are connected by the upper insertion tool 5, and the lower insertion tool 6
An IV needle 9 is connected to to connect the system to the patient. Further, although the socket 2 and the air chamber 3 are directly connected as shown in the drawing, it is not particularly limited whether they are directly connected or connected by using a connecting pipe.

Since what is shown is directly connected, the droplet outlet 7 is located at the outlet of the socket 2 and thus at the inlet of the air chamber 3. A screen 8 is provided in the air chamber 3 to take out inappropriate contaminants from the liquid passing therethrough and prevent them from being injected into the body. The screen 8 also does not necessarily have to be provided in the air chamber 3. An independent filtering tool may be provided in the system by using a connecting pipe, or may be provided inside the socket 2 and above the droplet outlet 7. Further, 10 is an injection site provided in the system as required, and is used when it is inevitable to inject a special drug into a medical fluid by using a syringe or a connecting tube connecting another medical fluid. A cartridge described later is connected to the socket 2 to form a set for performing a passive drug release method.

FIG. 2 is a front sectional view showing the inside of an example of the socket. The socket 2 has a socket inlet 11 at one end and a socket outlet 12 at the other end. The socket inlet 11 is connected to the upper insertion tool 5 using a connecting pipe, and is connected to the medical liquid container 1. The socket outlet 12 is connected to the air chamber 3. The socket outlet 12 is provided with the droplet outlet 7. If the socket outlet 12 is not directly connected to the air chamber 3, the droplet outlet 7 is provided at the inlet of the air chamber connected to the socket outlet 12 using a connecting pipe. The split plate 1 is inside the socket 2.
4 is provided to divide the socket into an upper chamber 17 and a lower chamber 18. Further, the division plate 14 is provided with a through hole 15.

The portion of the dividing plate 14 including the through hole 15 has elasticity, and when a rod-shaped member having a diameter larger than the diameter of the through hole is inserted into the through hole 15, this is received. Of course, all of the dividing plates 14 may be elastic, that is, made of rubber-like material. Further, the socket 2 is provided with a cartridge mounting portion 16.
The mounting portion 16 is made of an elastic material capable of piercing and holding a needle-shaped object. As such, the cartridge mounting portion 16 closes the upper chamber 17. The through hole 15 of the dividing plate is the cartridge mounting portion 16
It is located directly below.

FIG. 3 is a front sectional view of an example of the cartridge. The cartridge 20 shown in FIG. 3 shows a state before being mounted in the socket 2. The cartridge 20 has an adapter 21. The adapter 21 holds the cannula 27 on the lower side and mounts the drug container 22 on the upper side. The adapter 21 has a support horizontal plate 30 on the lower inside.
The supporting horizontal plate 30 is provided with a holding tube 31 inside thereof. The cannula 27 is supported inside the holding tube 31. A slit is provided between the inner wall of the holding tube 31 and the outside of the cannula 27 in the direction in which the cannula extends, that is, in the vertical direction. That is, assuming that the cannula 27 is the axle of the vehicle, the retaining tube 31 exists in a state like a wheel of a vehicle, and a thin plate radially extends in the vertical direction in a cross section between the retaining tube 31 and the cannula 27. There is a thin gap 34 that extends vertically between the thin plates.

The cannula 27 is fixed by a holding tube 31, is composed of a thin hollow tube, and has an upper opening 28 and a lower opening 2.
9 is open. Reference numeral 33 denotes a protective portion fixed to the cannula 27, which is located above the holding portion of the cannula 27 that is held by the holding tube 31. The protector 33 is located outside the cannula 27, is wound around the cannula 27, and has a distance from the upper end of the holding tube 31. That is, the protection portion 33 is provided so as not to close the narrow gap 34 between the holding tube 31 and the cannula 27. Reference numeral 32 denotes a lower cover that protects the vicinity of the lower opening 29 of the cannula 27, which can be removed at the time of use. The adapter 21 near the outside of the lower cover 32
In order to easily attach the entire cartridge to the socket 2, the concave and convex portions are provided so as to be engaged with the opposing sections of the socket.

In FIG. 3, reference numeral 24 denotes a soft material for maintaining the airtightness of the medicine container 22 and a stopper made of a material that is easily torn off, for example, a rubber stopper, 25
Is a thin metal cap for crimping the rubber plug 24, for example, an aluminum cap. The rubber stopper 24 is tightly fitted to the medicine container 22, and when the medicine container 22 is pushed downward, the rubber stopper 24 can move downward in the adapter 21. An upper cover 26 is attached to the adapter 21 so that the medicine container cannot be pushed down carelessly. In order to push down the medicine container 22, first, the upper cover 26 is removed from the adapter 21, and then the medicine container 2
2 is pushed down. Upper mouth 28 of cannula 27
Faces a near position under the stopper 24.

FIG. 4 shows the cartridge 2 of FIGS. 2 and 3.
The state where 0 is incorporated in the socket 2, that is, the use state is shown. For installation, first the upper cover 26 of the cartridge 20 is removed and the drug container 22 is pushed down.
At this time, the upper mouth 28 of the cannula penetrates the rubber stopper 24 and the thin metal cap 25 and enters the medicine container 22. When the medicine container 22 is further pushed down, even the protective portion 33 of the cannula 27 enters the medicine container 22 beyond the rubber stopper 24 and the thin metal band 25. Cannula holding tube 31
There is a gap between the upper end of the medicine container 22 and the protection portion 33, and the medicine container 22 is pushed down until this portion is also located in the medicine container 22. Then, the lower cover 32 also hits the medicine container 22 and is pushed down, and can be easily removed from the adapter 21.

Next, the lower cover 32 of the cartridge 20.
Of the cannula 27 so that the lower opening 29 of the cannula 27 faces the cartridge mounting portion 16 of the socket 2.
Pierce through. When the cartridge is further pushed down, the lower opening 29 of the cannula is exposed to the through hole 15 of the dividing plate 14, and is pushed and expanded to penetrate downward. At this time, the lower end of the holding tube 31 is inside the upper chamber 17, and the through hole is closed between the upper chamber 17 and the lower chamber 18 by the cannula 27 so that the direct communication passage is lost.

FIG. 5 schematically shows the main part of the present invention. First, the situation of passive drug release will be described with reference to FIG. Before the cartridge 20 is attached to the socket 2, the medical liquid reaches the socket inlet 11 of the socket 2 from the medical liquid container 1 and enters the upper chamber 17. Then, it enters the lower chamber 18 through the through hole 15 of the dividing plate 14. Further, since the droplet outlet 7 is provided at the socket outlet 12 of the lower chamber 18, the medical liquid drips from the droplet outlet 7. Next, when the cartridge 20 is attached to the socket 2, the through hole 15 of the upper chamber 17 is closed by the cannula 27, so that the medical liquid forms a narrow gap 34 formed between the outside of the cannula 27 and the inside of the holding tube 31. After that, it enters the lower part of the medicine container 22 from the upper end of the holding tube 31. There, the medical fluid comes into contact with the drug.

Here, the medical liquid generally dissolves the drug, but may be simply mixed. In any case, the medical liquid and the drug are agitated to be in a sufficiently diffused state. The medical liquid gradually rises in the medicine container 22 while being dissolved or mixed, finally reaches the upper opening 28 of the cannula, enters the cannula 27 from there, and flows downward in the cannula 27 to enter the lower chamber 18. . Therefore, the lower chamber 18 contains the medical liquid containing the drug. In the case shown in the figure, the socket outlet 12 of the lower chamber 18 is provided with the droplet outlet 7, so that the medical liquid containing the medicine drips from the droplet outlet 7.

Inside the drug container 22, a cannula 27
As the medical liquid containing the drug flows downward through the cannula 27 from the upper mouth 28, the inside of the drug container 22 becomes slightly negative pressure, so that the medical liquid is sucked up through the gap 34 and is lifted up. The upper opening 2 of the cannula 27 introduced into 22
8 keeps the liquid level. The medical liquid gradually flows out, the position of the head thereof passes through the medical liquid container 1, reaches the socket inlet 11 of the socket 2, and enters the upper chamber 17. Upper chamber 1
When reaching the lower end of the holding tube 31 contained in 7, the medical liquid does not flow into the drug container 22. If left as it is, the medical liquid will remain mainly in the medicine container 22 and in the upper chamber 17 of the socket, with some medicine.

To avoid residue, it is necessary to remove the cannula 27 from the through hole 15. That is, for this purpose, it is necessary to pull up the cannula 27 together with the medicine container 22. When the through hole 15 is first opened by lifting, the medical liquid in the upper chamber 17 flows out to the lower chamber 18. During this period, the medical liquid having a slight medicinal component is passed through the narrow space 34 between the holding tube 31 and the cannula 27 and is dropped into the lower chamber 18 through the upper chamber 17 and the socket outlet 12 Get out of. As a result, the last condition may not be a smooth termination, as the presence of the drug is interrupted or re-existed when trying to avoid residue. Depending on the type of drug and the quality and amount of medical fluid, it may be less preferable.

The above description is an example of a passive drug release system. In the above description, the socket and the cartridge are separate bodies, and further, the cartridge is such that the drug container can be moved in the adapter. However, the method of utilizing the present invention is not limited to the one described. That is, the fact that the socket and the cartridge are separate bodies and that the drug container can be moved in the adapter has nothing to do with whether the method of the present invention can be used. The point is that a cannula is inserted into the drug container, and the medical liquid passes near the outside of the cannula and enters the drug container to come into contact with the drug and agitate and dissolve, sometimes with agitation and mixing, and provided on the upper part of the cannula. If it is discharged from the upper mouth, it can be used as a passive drug release system. Furthermore, it is complete if the medical liquid has a flow path that does not come into contact with the medical liquid before and after entering the drug container under normal use. Other than that is not a condition for using the present invention.

Therefore, the present invention provides a small hole in the medicine container 22 below the cannula 27.
In FIG. 5, the small hole 36 is the protective portion 33 of the cannula 27.
Below the holding tube 31. Also small hole 35
Is provided just above the protective portion 33 of the cannula.
Generally, the small holes 35 and the small holes 36 may be selectively provided. FIG. 5 is shown in one drawing for convenience. However, it does not refuse to provide two small holes in one cannula. By providing a small hole in the cannula, there is substantially no concern that the medical liquid will remain with the drug in the drug container 22.

Even if the small holes 35 or 36 exist, the liquid is moved in the same manner as the conventional one until the amount of the medical liquid decreases and the medical liquid entering the medicine container 22 from the upper chamber 17 is exhausted. When the amount of the medical liquid decreases and the medical liquid does not enter the medicine container 22 through the upper chamber 17, the flow of the liquid becomes different from the conventional one. That is, when the medical liquid advances from the upper chamber 17 to the drug container 22, the air inside the drug container pushed by the inflowing medical liquid passes through the inside of the cannula 27 having the small holes 35 or 36. 35 or 36 is in a state of forming a gas-liquid interface. Therefore, the medical liquid that has entered the medicine container 22 is
Do not enter the cannula through the stoma. Eventually, when the medical liquid descends with the drug in the cannula,
Liquid is sucked on both sides of the small hole, but the inside and outside are balanced and the liquids do not mix.

When a predetermined amount of the medical liquid flows, the communication passage of the socket 2 is emptied from the medical liquid container, and then the liquid level in the upper chamber also drops. Then, the inflow of the medical liquid into the drug container 22 from the liquid inlet side of the holding tube 31 in the upper chamber 17 is also stopped. Therefore, the flow of the liquid through the upper port 28 disappears. However, the position of the stoma 35 or 36 is below the cannula in the drug container 22. Therefore, the liquid starts to enter the inside of the cannula through the small hole, and at least the mixture of the drug and the medical liquid existing in the drug container 22 is kept in the cannula as far as the level of the small hole. Move down. Since the position of the stoma 35 or 36 is below the cannula 27 in the drug container 22, the residual liquid in the drug container is reduced to the extent that it is considered substantially absent.

The small hole may be located below the cannula 27 and inside the drug container. Top 2 of cannula 27
If it is lower than 8, a certain effect can be achieved. Specifically, the holding tube 3 is provided under the protection portion 33 of the cannula.
Providing on top of 1, or just above the protective part 33 of the cannula increases the effect. Since the size of the protection portion 33 is not substantially so large, the difference in effect is small in either case. The point is to decide the position considering the ease of processing and the durability of the cannula.

In contrast to the present invention, it may be considered that the problem of residual liquid will not occur if the upper mouth of the cannula is placed at a low position, but this is not substantial. That is, when the position of the upper mouth of the cannula is lowered, the mixing of the medical fluid and the medicine is not uniform, and sometimes the medicine exists in a state incompatible with the medical fluid, which may even close the upper mouth of the cannula. . Therefore, it is preferable that the upper opening 28 of the cannula is as high as possible in terms of stirring. Finally, when the cannula 27 is pulled out, as the medical liquid retained in the upper chamber 17 moves to the lower chamber 18, a small amount of what remains in the drug container moves to the lower chamber via the upper chamber. The amount is negligible.

[0027]

INDUSTRIAL APPLICABILITY The present invention relates to a passive drug releasing system in which substantially one cannula is inserted into a drug container and a medical fluid is introduced along the outside of the cannula, and Separately, by providing a small hole under the cannula in the drug container, it is possible to prevent the medical fluid and the drug from remaining in the drug container, which is a very substantial effect. This makes it possible to prevent the release system from becoming more or less likely to be defective and to certainly enhance the advantages of the passive drug release system.

[0028]

[Brief description of drawings]

FIG. 1 is an overall configuration diagram showing an example of a passive drug release system in which the present invention is used.

FIG. 2 is a front sectional view of an example of a socket when the present invention is also used.

FIG. 3 is a front sectional view of an example of a cartridge when the present invention is also used.

FIG. 4 is a front sectional view showing an example of a usage state when the present invention is also used.

FIG. 5 is a schematic view of a usage state of the present invention.

[0029]

[Explanation of symbols]

 1: Medical liquid container 2: Socket 3: Air chamber 4: Flow controller 5: Upper insertion tool 6: Lower insertion tool 7: Droplet outlet 8: Screen 9: Intravenous injection needle 10: Injection site 11: Socket Inlet 12: Socket outlet 14: Dividing plate 15: Through hole 16: Cartridge mounting part 17: Upper chamber 18: Lower chamber 20: Cartridge 21: Adapter 22: Drug container 23: Drug 24: Rubber stopper 25: Metal cap 26: Upper Cover 27: Cannula 28: Cannula upper port 29: Cannula lower port 30: Support lateral plate 31: Holding tube 32: Lower cover 33: Protective part 34: Void between holding tube and cannula 35: Small hole 36: Small hole

Claims (4)

[Claims] 1. A medical fluid is passed through a drug container to release the drug into the medical fluid. A cannula is inserted into the drug container, and the medical fluid is supplied from a position near the outside of the cannula. In a passive drug-releasing device of a type that is introduced into the medical container, in which a medical liquid in which a drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container, the inside and outside of the cannula are positioned below the cannula in the drug container. A passive drug-releasing device, which is provided with a small hole communicating therewith. 2. A small hole communicating between the inside and the outside of the cannula is located near the end of a narrow gap for introducing a medical liquid into the drug container concentrically with the cannula along the outside of the cannula. The passive drug delivery device of claim 1 characterized. 3. A small hole communicating between the inside and the outside of the cannula is located near an upper end of a protection portion provided below the cannula for protecting the cannula when inserting the cannula into the drug container. Item 2. The passive drug releaser according to Item 1. 4. A medical fluid is passed through a drug container to release the drug into the medical fluid. A cannula is inserted into the drug container, and the medical fluid is supplied from a position near the outside of the cannula. A method in which a medical liquid in which a drug is dissolved or mixed is discharged from the vicinity of the tip of the cannula to the outside of the drug container has an inlet connected to the medical liquid container, an outlet for the medical liquid mixed with the drug, and a dividing plate. A cartridge mounting portion is provided in the upper chamber formed by the holding plate, the socket having a through hole closed by a cannula in the dividing plate, and the elastic portion provided in the cartridge mounting portion is pierced with the cannula and fixed. , The through hole of the dividing plate is closed below the cannula, and the tip of the through hole of the dividing plate of the cannula faces the lower chamber formed by the dividing plate, and the drug container is attached to the other end of the cannula. A cannula was inserted into the medication container,
A small space for passing medical fluid is provided on the outside of the cannula at the fixed part of the cannula with the cartridge,
Passive drug delivery device according to claim 1 or claim 2 or claim 3, characterized in that the cartridge is removable.