JPH09176021A - Wound covering material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a wound covering material capable of quickly drying wound(s), mitigating its pain, and promoting its cure. SOLUTION: This wound covering material is composed of polyvalent metal alginate fine particles 1 and a substrate for holding the fine particles 1 on a wound face 4 (a film-forming material such as a polysaccharide, derivative therefrom or polyamino acid-based compound, or a synthetic polymeric material, or a tack material such as oil-and-fat, a hydrocarbon, higher fatty acid, higher alcohol, sterol compound, fatty acid ester or polyhydric alcohol). It is preferable that the fine particles account for 0.1-30wt.% of the whole wound covering material and the average diameter of the fine particles 1 determined in air is 0.1-100μm.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a wound dressing material for covering and protecting an affected area in the treatment of burns, cuts, abrasions, ulcers and the like.

[0002]

2. Description of the Related Art Conventionally, in the treatment of burns, cuts, abrasions, ulcers, etc., cotton, gauze, non-woven fabric, ointment and the like have been used as wound dressing materials for covering and protecting the affected area. For burns, pigskin, non-woven fabric made of chitin fiber, etc. are used.

However, cotton products such as gauze are not sufficiently water-absorbent, and they have the drawback that they cannot absorb the body fluid leaching from the wound promptly. In addition, since cotton products release moisture slowly, they tend not to dry and tend to cause scratches, and in order to prevent this, the cotton product for wound dressing must be frequently replaced, which is a problem. It was Further, the ointment has a drawback in that it has a low wound covering effect and is time-consuming to treat.

On the other hand, recently, an alginic acid-based wound dressing material has been proposed (for example, JP-A-7-13624).
No. 0, JP-A-7-155369). All of these alginic acid-based wound dressings use fibrous alginate processed into a non-woven fabric or a fabric. Therefore, the non-woven fabric must be stopped with a film or a plaster with an adhesive to fix it to the wound, which is an obstacle to prompt treatment. This is similar to the previous gauze.
Further, since the film is used to fix the alginic acid fiber, when the moisture permeability of the film is low, the wound is rather peeled. According to the description of the above-mentioned published patent publication, the wound dressing made of alginate fiber absorbs body fluid and gels, has a hemostatic effect, relieves pain, and maintains a wet state suitable for promoting treatment. The view is that it has the effect of. Nonwoven fabrics using these fibrous alginates absorb the body fluid that exudes from the wound, and swell to maintain the wound in a moist state, but the effect of hemostasis and pain relief and promotion of treatment are not sufficient. Hard to say. Rather, the alginate fiber retains body fluid, and since it is difficult for it to diffuse, the wound is often broken. As described above, many wound dressings currently in use have a drawback in that the wound is easily dislodged.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made to solve the above-mentioned problems of the prior art, and a wound dressing having functions of promptly drying a wound, relieving pain, and promoting healing. The challenge is to provide.

[0006]

As a means for solving the above problems, the present invention uses, as a film-forming material, specific fine particles having a function of promptly absorbing body fluids leaching from a wound and releasing water quickly. It is to be blended.
That is, the present invention, alginic acid polyvalent metal salt fine particles,
A wound dressing material comprising a particle holding material for holding the fine particles on a wound surface, wherein the content of the fine particles is 0.1 to 30% by weight of the whole wound dressing material. Is.

The present invention is intended to effectively utilize the moisture absorbing / releasing characteristics of the alginic acid polyvalent metal salt and the dimensional stability when wet, from the viewpoint of wound protection. The "moisture breathability" of the polyhydric alginic acid salt, which absorbs and dissipates moisture according to the ambient humidity, has the function of quickly drying the wound while keeping the wound in an appropriate humidity environment. In the present invention, in order to fully exert the function of such a polyvalent metal salt of alginic acid,
The polyvalent metal salt of alginic acid is in the form of fine particles, and the fine particles are held in a film form on the wound surface by a particle holding material.

With respect to this point, FIGS. 1 and 2 show conceptual views of examples of the wound dressing of the present invention. That is, FIG.
Shows a case where a film forming material such as a polymer compound is used as a particle holding material and a film containing fine particles of polyvalent metal salt of alginic acid is formed on the wound surface. Further, in FIG. 2, an adhesive material is used as a particle holding material so that the alginic acid polyvalent metal salt fine particles do not fall off from the wound surface. Of course,
Although the form of the wound dressing of the present invention is not limited to these, it is possible to disperse the alginic acid polyvalent metal salt fine particles excellent in water respiration and dimensional stability on the wound surface.
If the wound dressing of the present invention that can be retained is used, the body fluid that exudes from the wound can be quickly absorbed, and the wound can be dried by rapidly releasing the body fluid, so that the pain can be relieved and healing can be performed. The promoting effect can be remarkably improved.

[0009]

Embodiments of the present invention will be described below in detail.

(1) Fine particles of polyvalent metal salt of alginic acid Alginic acid is one kind of polysaccharide, and is mannuronic acid and its isomer, glucuronic acid (C ₅ H ₉ O ₅ .COO).
It is a dehydrated polymer of H). Alginic acid is usually obtained by treating a sodium carbonate extract of dried seaweed with hydrochloric acid. The polyvalent metal salt of alginic acid of the present invention has a structure in which alginic acid is crosslinked with a polyvalent metal ion, and unlike alginic acid, it is insoluble in water. Further, the polyvalent metal salt of alginic acid may exhibit a gel state simply by crosslinking with a polyvalent metal ion, but in the present invention, it is necessary to use a fine particle form, preferably by a laser light scattering method. The average particle size measured in air is 0.
The particles (beads) having a particle size of 1 to 100 μm, preferably 1 to 80 μm are used.

Such a polyvalent metal salt of alginic acid can be obtained, for example, by preparing an aqueous solution of a monovalent metal salt of alginic acid and an alkali metal such as sodium or potassium into fine particles by a spray drying method, an emulsion method or the like, and then adding the polyvalent metal salt. It can be obtained by immersing in an aqueous solution containing ions. Further, the aqueous solution of the monovalent metal salt of alginic acid or the one obtained by treating it with an acid may be stirred with an aqueous solution having polyvalent metal ions, and then the insoluble matter may be separated, dried and pulverized to obtain a granular material. .

Here, as the polyvalent metal salt, calcium, zinc, magnesium, barium, strontium,
Examples thereof include metal salts with copper, iron, aluminum, cobalt and the like. Among them, calcium alginate, zinc alginate, magnesium alginate and barium alginate are preferable, and calcium alginate is particularly preferable.

The fine particles of calcium alginate are excellent in water breathability, and even if they absorb moisture, there is little difference in shape and size. FIG. 3 shows the results of measuring the water respiration of calcium alginate beads. This is because the sample pre-dried in an atmosphere of 20% relative humidity was placed in an atmosphere of 95% relative humidity, the weight change was recorded, and when equilibrium was reached (the sample was placed in an atmosphere of 95% relative humidity). 100 hours after the start), the sample was moved again to a relative humidity atmosphere of 20%, and the change in weight was recorded. It can be seen that the calcium alginate beads have a higher water respiration property than silica gel, zeolite, or microcrystalline cellulose that is usually used as a granular filler.

FIGS. 4 and 5 show the particle size distribution of calcium alginate beads and cellulose fine particles (trade name AC powder, manufactured by Nisshinbo Industries Inc.) produced in Example 2 in the air and in water. It is the result measured by the laser light scattering method using. Regarding the particle size of the calcium alginate beads, for example, when the average particle size in air is 35 μm, the average particle size in water is 38 μm.
It can be seen that even in water, there is almost no swelling and there is no significant difference from the value in air (Fig. 4). Further, for example, even if the average particle size in air is 100 μm, the average particle size in water is only 110 μm. On the other hand, cellulose fine particles have, for example, an average particle size in air of 40
In the case of μm, the average particle size in water is 60 μm (FIG. 5).

As described above, the fine particles of polyvalent metal alginic acid salt according to the present invention have both high water breathability and excellent dimensional stability when absorbing moisture. It is possible to obtain a wound dressing that does not cause

In the wound dressing of the present invention, the fine particles of polyvalent metal alginate are 0.1 to 3 in the total weight of the wound dressing.
It is preferable to contain 0% by weight. If the content of the fine particles of polyvalent metal salt of alginic acid is less than 0.1% by weight, the effect of adding the compound will not be sufficiently exhibited because it is too small.
On the other hand, if the content is more than 30% by weight, the wound coating film becomes too thick and peels off, or stuffiness of the wound occurs, which is not preferable.

(2) Particle Retaining Material As the particle retaining material of the present invention, a film forming material capable of forming a film on the wound surface as shown in FIG. 1 can be used. Examples of substances that can be used as the film-forming material include polymer compounds that do not harm the human body. The polymer compound listed in the Japanese Pharmacopoeia, which has established safety as a pharmaceutical material, or the polymer compound listed in the cosmetics basis, which is recognized as a cosmetic material, or the safety as a quasi drug, is recognized. It is preferable to use a polymer compound whose safety is confirmed as a food compound or a food additive, but any polymer compound can be used as long as it is a polymer compound whose safety to the human body is established. You can Of course, it is necessary to perform a sufficient safety test before use to determine the blending amount.

[0018] Preferably, the film-forming agent is selected from the group consisting of naturally occurring polysaccharides, polyamino acid compounds such as proteins, polysaccharide derivatives chemically modified from polysaccharides, and synthetic polymeric substances. Molecular compounds are used.

Examples of naturally occurring polysaccharides include cellulose, gum arabic, tragacanth gum, guar gum,
Galactan, carob gum, locust bean gum, karaya gum, iris moss, quince seed, gelatin,
Examples thereof include shellac, rosin, pectin, agar, starch, glycyrrhizinic acid, arge colloid, xanthan gum, dextran, succinoglucan, pullulan and curdlan.

As the polysaccharide derivative, sodium carboxymethyl cellulose, hydroxyethyl cellulose,
Examples thereof include cellulose derivatives such as hydroxypropyl cellulose, methyl cellulose, ethyl cellulose and nitrocellulose, sodium carboxymethyl starch, hydroxyethyl starch, hydroxypropyl starch, sodium alginate, propylene glycol alginate ester, ester gum, and crystalline cellulose.

Examples of polyamino acid compounds include proteins such as casein, albumin, collagen and gelatin. As the synthetic polymer substance, polyvinyl alcohol, polyvinylpyrrolidone, sodium polyacrylate, carboxyvinyl polymer, polyvinylmethyl ether, polyamide resin, polyethyleneimine, dimethylpolysiloxane in the silicon series, methylphenylpolysiloxane, methylhydrogenpolysiloxane,
Examples thereof include cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane, and polysiloxane resins that form a three-dimensional network structure.

These may be used alone or in combination of two or more. Further, the polymer compounds that can be used as the film-forming material are not limited to these exemplified polymer compounds.

Further, as the particle holding material of the present invention, in addition to the film forming material made of the above-mentioned polymer compound,
As shown in FIG. 2, an adhesive may be used to prevent the alginic acid polyvalent metal salt particles from falling off from the wound surface. As this adhesive material, as well as the above-mentioned film forming material, a material whose safety to the human body is established is used.
Specific examples of the adhesive material include avocado oil, almond oil,
Olive oil, cacao oil, beef tallow, sesame oil, wheat germ oil, safflower oil, shea butter, turtle oil, camellia oil, persic oil, castor oil, grape oil, macadamia nut oil, mink oil, egg yolk oil, mokuro, palm oil, rose hips Oils and fats such as hardened oils; orange luffy oil, carnauba wax, candelilla wax, whale wax, jojoba oil, montan wax, beeswax, lanolin, lanolin and other waxes; liquid paraffin, vaseline, paraffin, ceresin, microcrystalline wax, Hydrocarbons such as squalane; lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, behenic acid, undecylenic acid, oxystearic acid, linoleic acid, lanolin fatty acid, higher fatty acids such as synthetic fatty acids; lauryl alcohol, cetyl alcohol, Seto Lil alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol,
Higher alcohols such as lanolin alcohol, hydrogenated lanolin alcohol, octyldodecanol, and isostearyl alcohol; sterols such as cholesterol, dihydrocholesterol, phytosterol; linoleic acid ester, isopropyl myristate, lanolin fatty acid isopropyl, hexyl laurate, myristyl myristate. , Cetyl myristate, octyldodecyl myristate, decyl oleate, octyldodecyl oleate, hexyldecyl dimethyloctanoate, cetyl isooctanoate, cetyl palmitate, trimyristine glycerin, tri (capryl-caprate) glycerin, propylene glycol dioleate , Glycerin triisostearate, glyceryl triisooctanoate, cetyl lactate, myrithyl lactate Le, fatty acid esters such as diisostearyl malate; such as polyhydric alcohols, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3
-Butylene glycol, pentamethylene glycol, 2
-Butene-1,4-diol, hexylene glycol,
Divalent alcohols such as octylene glycol; trivalent alcohols such as glycerin, trimethylolpropane, 1,2,6-hexanetriol; tetrahydric alcohols such as pentaerythritol; pentavalent alcohols such as xylitol; sorbitol, mannitol, etc. Hexahydric alcohol,
Polyhydric alcohol polymers such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether , Ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2
-Methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether,
Divalent alcohol alkyl ethers such as ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether; diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether , Diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, Dihydric alcohol alkyl ethers such as pyrene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether; ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene Glycol monophenyl ethyl acetate, ethylene glycol diabate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol Dihydric alcohol ether esters such as monopropyl ether acetate and propylene glycol monophenyl ether acetate; glycerin monoalkyl ethers such as xyl alcohol, ceracyl alcohol and batyl alcohol, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol. , Glucose, fructose, amylolytic sugar, maltose, xylitose,
Sugar alcohol such as starch-decomposing sugar reducing alcohol; Glysolid, tetrahydrofurfuryl alcohol, PO
E Tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, tripolyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphoric acid, POP
POE pentaerythritol ether and the like;

Further, sodium dl-pyrrolidone carboxylate, sodium lactate, sorbitol, sodium hyaluronate and the like can be mentioned. Further, the polymer compound shown as the film forming material can be used as an adhesive. Also, two or more of these may be combined and blended. You may use combining 2 or more types of both a film forming material and an adhesive.

(3) Other compounding ingredients The wound dressing is further compounded with a surface active agent such as an anionic surface active agent, a lipophilic or hydrophilic nonionic surface active agent, a cationic surface active agent, and an amphoteric surface active agent. May be.

Examples of lipophilic nonionic surfactants include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, Sorbitan fatty acid esters such as penta-2-ertihexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan; monocotton oil fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, monostearate glycerin, α,
Glycerin (or polyglycerin) fatty acid esters such as α'-glyceryl pyroglutamate and glycerin monostearate malic acid; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivative, glycerin alkyl ether, etc .; Is mentioned.

Examples of the hydrophilic nonionic surfactant include POE sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, and other POE sorbitan fatty acid esters; POE- Sorbit Monolaurate, POE-Sorbit Monooleate, POE
-POE sorbit fatty acid esters such as sorbit bentooleate and POE-sorbit monostearate; POE glycerin fatty acid esters such as POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate; POE monooleate, POE distearate,
POE monodiolate, POE fatty acid esters such as ethylene glycol distearate; POE lauryl ether, POE oleyl ether, POE-stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE cholestanol ether and other POE alkyl ethers POE alkyl phenyl ethers such as POE octyl phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether; POE / POP cetyl ether, POE / POP
2-decyl tetradecyl ether, POE / POP monobutyl ether, POE / POP hydrogenated lanolin, POE
-POE / POP alkyl ethers such as POP glycerin ether; POE / POP ethylenediamine condensates; POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated Castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil maleic acid and other POE castor oil (or hydrogenated castor oil) derivatives; POE sorbit beeswax and other POE
Beeswax lanolin derivatives; alkanol amides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide; POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, fatty acid ester such as P, P
OE nonylphenyl formaldehyde condensate, alkylethoxydimethylamine oxide, trioleylphosphoric acid and the like;

Examples of the anionic surfactant include a base for soap, a fatty acid soap such as sodium laurate and sodium palmitate; a higher alkyl sulfate ester salt such as sodium lauryl sulfate and K lauryl sulfate;
POE lauryl sulfate triethanolamine, POE sodium lauryl sulfate and other alkyl ether sulfate salts; N-acyl sarcosinic acid such as lauroyl sarcosine sodium; N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium,
Higher fatty acid amide sulfonates such as sodium lauryl methyl tauride; phosphate ester salts such as sodium POE oleyl ether phosphate and POE stearyl ether phosphate; sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene Alkylbenzene sulfonates such as sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinate sodium sulfosuccinate, sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonate; N-lauroyl glutamic acid monosodium salt , N-stearoyl glutamate disodium, N-myristoyl-L-glutamate monosodium, etc. Acyl glutamate; Hardened coconut oil Fatty acid Fatty acid ester Sulfate ester such as sodium glycerin sulfate; Sulfated oil such as funnel oil; POE alkyl ether carboxylic acid, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary Alcohol sulfate ester salt, higher fatty acid alkylolamide sulfate ester acid, sodium lauroyl monoethanolamide succinate, ditriethanolamine N-balmitoyl aspartate, sodium caseinate and the like;

Examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; poly (N, N-).
Dimethyl-3.5-methylenepiperidinium), an alkylpyridinium salt such as cetylpyridinium chloride; an alkyl quaternary ammonium salt, an alkyldimethylbenzylammonium group, an alkylisoquinolinium salt, a dialkylmorphonium salt, a POE alkylamine, Examples include alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride, β-NN-dimethyl-N-ethylammonioethyl acrylate vinylpyrrolidone copolymer, and cationic polymer derivatives. .

Examples of the amphoteric surfactant include 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl. Imidazoline-based amphoteric surfactants such as roxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, betaine lauryldimethylaminoacetate betaine, alkyl betaine, amidobetaine, sulfobetaine, and other betaine Examples thereof include surfactants.

The wound dressing further comprises, as a powder component,
Talc, carion, mica, sericite, muscovite, phlogopite, synthetic mica, phlogopite, biotite, lithia mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, barium sulfate, magnesium sulfate, silica Calcium acid, aluminum silicate,
Barium silicate, barium sulfate, strontium silicate, metal tungstate, silica, zeolite, barium sulfate, calcined calcium sulfate (calculated gypsum), calcium phosphate, fluoroapatite, hydroxyapatite,
Ceramic powder, metal soap (zinc myristate, calcium palmitate, aluminum stearate),
Boron nitride, cerium oxide, magnesium aluminometasilicate, magnesium aluminosilicate, aluminum hydroxychloride, aluminum chloride, aluminum sulfate, aluminum citrate, aluminum acetate, basic aluminum chloride, aluminum phenolsulfonate, β-naphtholdisulfonic acid Inorganic powder of aluminum, sodium perborate, aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium trichlorohydrate, zirconium hydrate, etc .; polyamide resin powder (nylon powder), Polyethylene powder, polymethylmethacrylate powder, polystyrene powder, styrene and Copolymer resin powder acrylic acid,
Organic powders such as polytetrafluoroethylene powder, polypropylene, chitin, chitosan, and cellulose powder; and the like may be blended.

Inorganic white pigments such as titanium dioxide, zinc oxide and zirconium oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; yellow iron oxide. Inorganic yellow pigments such as loess; black iron oxide,
Inorganic black pigments such as carbon black and low order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue such as ultramarine blue and navy blue. -Based pigments; titanium oxide coated mica, bismuth oxychloride, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, pearl pigments such as fish scale foil; metal powder pigments such as aluminum powder and copper powder; red 201 No., Red No. 202, Red No. 204, Red No. 205, Red No. 220
No. Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401
Color and organic pigments such as Blue No. 404; Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230
No. Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3
No. 1 and Blue No. 1, zirconium, barium or aluminum lake pigments; natural pigments such as chlorophyll and β-carotene;

Further, depending on the intended use, agents for preventing purulence, antiseptics, local anesthetics, analgesics, skin formation promoters, corticosteroids, antibiotics, zinc oxide powder, sulfur powder, titanium oxide powder, talc, Kaolin, mica, calcium carbonate, magnesium carbonate, moisturizer, lower alcohol, fragrance, preservative, antibacterial agent, antioxidant, skin astringent, vitamins,
Placenta extract, elastin, collagen, aloe extract,
Chemicals or additives such as peach leaf extract, Hamamelis water, loofah water, chamomile extract, licorice extract and the like can be appropriately mixed and used.

The wound dressing of the present invention can be obtained by appropriately mixing the above-mentioned fine particles of polyvalent metal salt of alginic acid, the particle-holding material and various compounding ingredients used as necessary by a known method. The mixing method is not particularly limited,
For example, a kneader, a mixer, an impeller stirrer, etc. can be used.

The wound dressing of the present invention can be prepared as a dressing for spray application using an aerosol. The coating material for spray coating is not particularly limited as long as it can be used by being sprayed on the wound surface, and in addition to polyvalent metal alginate particles, liquefied petroleum gas, silicic anhydride, polyvinyl alcohol. , Polyoxyethylene sorbitan monooleate and the like can be blended.

In addition, the wound dressing of the present invention can be used in the form of an emulsion, suspension, cream or the like depending on the mode of use, and applied to the wound surface with fingers or instruments for use.

In any case, a film containing fine particles of polyvalent metal salt of alginic acid is formed to cover and protect the wound. The formed wound-covering film quickly absorbs the body fluid that has exuded from the wound and dissipates water, so that the wound surface dries quickly and leads to healing. The thickness of the film formed on the wound surface by the wound dressing of the present invention is usually 10 to 1000 μm.
m.

[0038]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples.

<Example 1: Preparation Example 1 of calcium alginate beads> Polyglycerin was prepared by dissolving 700 kg of sodium alginate obtained from dried seaweed in 10 times the amount of water, and using 5000 kg of n-hexane as an oil layer. Condensed ricinoleic acid ester (Taiyo Kagaku KK, trade name Sunsoft 818H) 7.
7 kg was used and emulsified using a homomixer. 6000 kg of this emulsified liquid 20% by weight calcium chloride aqueous solution
And ion-crosslinked to produce spherical particles of calcium alginate that are insoluble in water. After washing with water and drying, 49
0 kg of calcium alginate particles (average particle size 10μ
m).

<Example 2: Preparation example 2 of calcium alginate beads> A sodium alginate aqueous solution prepared by dissolving 700 kg of sodium alginate obtained from dried seaweed in 10 times the amount of water was spray dried (manufactured by Niro, Mobil). After spray-drying at a cylinder temperature of 230 ° C using a minor type atomizer) to form fine particles, it is contacted with a 20% calcium chloride aqueous solution for ionic cross-linking, water-insoluble and spherical (average particle size 35 μm) Calcium alginate beads of 500 g (dry weight conversion) are obtained,
This was spray dried.

<Example 3: Formulation example of cream type wound dressing> The blending components having the compositions shown in Table 1 below were mixed using a homomixer with a rotating stirring blade to obtain a cream type wound dressing. . When this wound dressing was applied to an abraded wound, bleeding and exudate were scarcely observed, and the wound was healed.

[0042]

[Table 1] Table 1 ───────────────────────── Weight of composition component ────────────── ─────────── Fine particles of calcium alginate of Example 1 20 g Ethanol 20 g Propylene glycol 8 g Glycerin 1 g Purified water 51 g ───────────────────── ─────

<Example 4: Cream-type wound dressing formulation example> The respective components of the composition shown in Table 2 below were mixed in the same manner as in Example 3 to obtain a cream-type wound dressing. When this wound dressing was applied to abrasions, bleeding,
Almost no exudate was seen and healed well.

[0044]

[Table 2] Table 2 ───────────────────────── Composition weight ─────────────── ─────────── Fine particles of calcium alginate of Example 1 20 g Polyvinyl alcohol (35-45 cps) 3 g Ethanol 20 g Propylene glycol 3 g Glycerin 1 g Purified water 53 g ────────────── ─────────────

<Example 5: Example of cream type wound dressing formulation> The respective components of the composition shown in Table 3 below were mixed in the same manner as in Example 3 to obtain a cream type wound dressing. When this wound dressing was applied to abrasions, bleeding,
Almost no exudate was seen and healed well.

[0046]

[Table 3] Table 3 ────────────────────────── Composition weight ────────────── ─────────────────────────────────────────────────────────────────────────────────────── 45cps) 10g ethanol 20g propylene glycol 3g glycerin 1g purified water 35.5g ───────────────────────────

<Example 6: Aerosol type (powder spray) wound dressing formulation example> The ingredients of the composition shown in Table 4 below are mixed in the same manner as in Example 3 to prepare an aerosol type (powder spray). A wound dressing was obtained. When this wound dressing was sprayed on the scratches, bleeding and exudate were scarcely observed, and the wound was healed.

[0048]

[Table 4] Table 4 ──────────────────────────── Composition weight ──────────── ───────────────── Fine particles of calcium alginate of Example 1 12 g Polyvinyl alcohol (35-45 cps) 0.5 g Polyoxyethylene sorbitan monooleate 0.1 g Silicic anhydride 0. 5g Liquefied petroleum gas 86.9g ────────────────────────────

<Example 7: Formulation example of aerosol type (powder spray) wound dressing> Each component of the composition shown in Table 5 below is mixed in the same manner as in Example 3 to prepare an aerosol type (powder spray). A wound dressing was obtained. When this wound dressing was sprayed on the scratches, bleeding and exudate were scarcely observed, and the wound was healed.

[0050]

[Table 5] Table 5 ──────────────────────────── Weight of the composition ──────────── ───────────────── Fine particles of calcium alginate of Example 1 7 g Polydimethylsiloxane 0.1 g Isopropyl myristate 0.5 g Polyvinyl alcohol (35-45 cps) 0.5 g Polyoxyethylene Sorbitan monooleate 0.1 g Silicic acid 0.5 g Liquefied petroleum gas 91.3 g ─────────────────────────────

<Example 8: Formulation Example of Aerosol Type (Powder Spray) Wound Dressing> The respective components of the composition shown in Table 6 below are mixed in the same manner as in Example 3 to prepare an aerosol type (powder spray). A wound dressing was obtained. When this wound dressing was sprayed on the scratches, bleeding and exudate were scarcely observed, and the wound was healed.

[0052]

[Table 6] Table 6 ──────────────────────────── Weight of composition ──────────── ───────────────── Fine particles of calcium alginate of Example 1 8 g Polydimethylsiloxane 0.1 g Isopropyl myristate 0.5 g Polyvinyl alcohol (35-45 cps) 0.5 g Polyoxyethylene Sorbitan monooleate 0.1 g Silicic acid 0.1 g Acrinol 0.2 g Allantoin 0.7 g d-camphor 0.5 g Liquefied petroleum gas 89.3 g ───────────────── ───────────

<Comparative Example 1: Cream-type wound dressing formulation example> The components of the composition shown in Table 7 below were mixed in the same manner as in Example 3 to obtain a cream-type wound dressing. Even if this wound dressing is applied to abrasions, bleeding stops,
Almost no exudate absorption effect was observed.

[0054]

[Table 7] Table 7 ──────────────────── Composition weight ──────────────────── ─ Ethanol 20g Propylene glycol 8g Glycerin 1g Purified water 51g ────────────────────

<Comparative Example 2: Aerosol type (powder spray) wound coating formulation example> The components of the composition shown in Table 8 below were mixed in the same manner as in Example 3 to form an aerosol type (powder spray) wound. A coating material was obtained. When the wound dressing was sprayed on the scratches, the added effect could not be found.

[0056]

[Table 8] Table 8 ──────────────────────────── Weight of the composition ──────────── ───────────────── Polydimethylsiloxane 0.1g Isopropyl myristate 0.5g Polyvinyl alcohol (35-45cps) 0.5g Polyoxyethylene sorbitan monooleate 0.1g Anhydrous Silicic acid 0.5 g Liquefied petroleum gas 98.3 g ────────────────────────────

[0057]

EFFECT OF THE INVENTION Since the wound dressing of the present invention contains fine particles of polyvalent metal salt of alginic acid having a function of promptly absorbing body fluids leaching from the wound and quickly releasing water, the wound can be swiftly wound. It is excellent in the effects of drying, relieving pain and promoting healing.

[Brief description of the drawings]

FIG. 1 is a schematic view showing an example of a wound dressing of the present invention.

FIG. 2 is a schematic view showing an example of the wound dressing of the present invention.

FIG. 3 is a diagram showing changes in water content with respect to changes in humidity of the respective compounding agents, in order to compare the water breathability of the calcium alginate beads of the present invention with silica gel, zeolite, and microcrystalline cellulose.

FIG. 4 is a graph showing changes in average particle diameter with respect to changes in humidity for checking the dimensional stability of the calcium alginate beads of the present invention.

FIG. 5 is a graph showing a change in average particle diameter of cellulose fine particles with respect to a humidity change, for comparing dimensional stability of calcium alginate beads of the present invention and cellulose fine particles (AC powder; manufactured by Nisshinbo Industries, Inc.). .

[Explanation of symbols]

1 ... Alginic acid polyvalent metal salt fine particles 2 ... Film-forming material 3 ... Film 4 ... Wound surface 5 ... Adhesive material 6 ... Curve showing water content of calcium alginate beads 7. ..Curve showing water content of silica gel 8 ... Curve showing water content of zeolite 9 ... Curve showing water content of microcrystalline cellulose 10 ... Particle size of calcium alginate beads measured in air Distribution curve 11 ... Particle size distribution curve of calcium alginate beads measured in water 12 ... Particle size distribution curve of cellulose fine particles measured in air 13 ... Particle size distribution curve of cellulose fine particles measured in water

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display area A61L 15/16 A61L 15/01

Claims (6)

[Claims] 1. A wound dressing comprising a polyvalent metal salt of alginic acid fine particles and a particle holding material for holding the fine particles on a wound surface. 2. The wound dressing according to claim 1, wherein the average particle size of the alginic acid polyvalent metal salt fine particles measured in air is 0.1 to 100 μm. 3. The particle-holding material comprises a film-forming material selected from the group consisting of naturally-occurring polysaccharides, polyamino acid compounds, polysaccharide derivatives, and synthetic polymeric substances.
Or the wound dressing according to 2. 4. The particle-holding material contains an adhesive material selected from the group consisting of fats and oils, hydrocarbons, higher fatty acids, higher alcohols, sterols, fatty acid esters, and polyhydric alcohols. The wound dressing according to. 5. The wound dressing material according to claim 1, wherein the content of the fine particles of polyvalent metal salt of alginic acid is 0.1 to 30% by weight of the whole wound dressing material. 6. The wound dressing according to any one of claims 1 to 5, wherein the wound dressing is a spray application dressing.