JPH09124433A - Dermal preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a dermal preparation for external use excellent in humectant effect and emollient effect, free from stickiness, and good in spreadability, use feeling, safety and stability. SOLUTION: This dermal preparation for external use contains, as active ingredients, (A) 0.05-5wt.% of a phospholipid (e.g. hydrogenated soybean phospholipid), (B) 0.05-5wt.% of cholesterol and/or a derivative therefrom and (C) 0.1-80wt.% of a silicone oil at the weight ratios A/B and C/(A+B) of pref. (10:1) to (1:1) and >=0.2, respectively. The skin preparation is made into cream, milky lotion, face lotion, liquid cosmetic, foundation, etc. by formulating the active ingredients, appropriately with a lubricant, surfactant, powder, pigment, dye, water-soluble polymer, ultraviolet light absorber, antiseptic, perfume, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin which is excellent in moisturizing effect and emollient effect and has reduced usability such as stickiness and has good usability.

[0002]

2. Description of the Related Art A lot of external preparations for skin intended for moisturizing effect and emollient effect have been researched and developed, but in recent years, active research on external preparations for skin with consideration for users with sensitive skin has been actively conducted. Therefore, there has been a demand for the development of an external preparation for the skin, which contains a moisturizing component that is safe and has low irritation to the skin effectively. Among them, the moisturizing component that has been attracting attention is phospholipid. Conventionally, phospholipids have been known as naturally-occurring emulsifiers and are used for many purposes in many fields. In the field of cosmetics, it is used as an extremely safe emulsifier or moisturizer in creams, emulsions, lotions, foundations and the like. Phospholipids have high moisturizing properties, but at present, there is a limit to the amount that can be blended due to the sticky feel on application to the skin. On the other hand, cholesterol is a type of intercellular lipid and has a high action of moisturizing the skin or preventing evaporation of water. Therefore, cholesterol and / or a derivative thereof is added together with a phospholipid to enhance the moisturizing effect. Attempts have been made to compensate for the limit of the amount in which the.

[0003]

However, when these phospholipids and cholesterol and / or their derivatives are simply blended in a skin external preparation base, the moisturizing effect is improved, but the solution to the feeling of stickiness and the like is solved. However, the moisturizing effect was notable at all, and the stickiness on touch was very strong, which was uncomfortable to use. Therefore, it has been desired to develop a skin external preparation having excellent moisturizing effect and emollient effect and reducing unpleasant feeling such as stickiness and having good usability.

[0004]

Means for Solving the Problems In view of these reasons, the present inventors have conducted intensive studies and, as a result, have blended phospholipids and cholesterol and / or derivatives thereof in a specific ratio, and have specified a silicone oil. It was found that the external preparation for skin is safe for the skin, excellent in moisturizing effect and emollient effect, and reduces unpleasant feeling such as stickiness when added in the ratio of That is,
The present invention contains a phospholipid as the component (A), cholesterol and / or a derivative thereof as the component (B), and silicone oil as the component (C), and the weight ratio of the (A) / (B) component is 10 /. A skin external preparation characterized by being in the range of 1 to 1/1 and having a weight ratio of the (C) / {(A) + (B)} components of 0.2 or more. . The present invention will be described in detail below.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The phospholipid of the component (A) used in the present invention includes phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipid, and the like, or their analogues. And a hydrogenated product thereof, that is, soybean lecithin, egg yolk lecithin and the like.
In the present invention, the above phospholipids may be used alone or in combination of two or more. The blending amount of the phospholipid as the component (A) is preferably 0.05 to 5.0% by weight (hereinafter simply referred to as "%"). The phospholipid content is 0.
When it is less than 05%, a sufficient moisturizing effect cannot be obtained,
Further, if it exceeds 5.0%, the odor of phospholipid becomes strong and the feeling of use becomes heavy, which may result in an unfavorable dosage form.

Examples of the component (B) cholesterol and / or its derivative used in the present invention include cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, dihydrocholesteryl oleate, cholesteryl nonanoate, cholesteryl butyrate, dihydrobutyrate. Cholesteryl, macadamia nut oil fatty acid cholesteryl, etc. are mentioned. The above cholesterol and / or its derivative can be used alone or in combination of two or more. The blending amount of the component (B), cholesterol and / or its derivative, is preferably 0.05 to 5.0%. When the amount of cholesterol and / or its derivative is less than 0.05%, the moisturizing effect required for the effect of the present invention cannot be obtained, and the moisturizing effect is comparable to the case of only adding phospholipids. Also, if it exceeds 5.0%, it may be difficult to maintain the stability of the dosage form.
Or, undesired things such as precipitation of crystals of the derivative may occur.

The silicone oil as the component (C) used in the present invention has a viscosity of 100 cs or less at 25 ° C. among dimethylpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane and the like. It is selected from silicone oils, and one or more of these may be used in combination. The blending amount of the silicone oil which is the component (C) is preferably 0.1 to 80%. When the content of silicone oil is less than 0.1%, the reduction in stickiness required for the effect of the present invention cannot be obtained, and when the content is more than 80%, various formulations are required for stabilizing the dosage form. It may be necessary to devise.

The ratio of the components (A) / (B) is 10/1 to 1
The range of / 1 is preferable. In this range, an excellent moisturizing effect and emollient effect are obtained due to the synergistic effect of adding cholesterol and / or its derivative to the phospholipid.

The ratio of the components (C) / {(A) + (B)} is preferably 0.2 or more. Within this range, a moisturizing effect and an emollient effect are excellent, and good usability with reduced stickiness can be obtained.

The external preparation for skin of the present invention comprises, in addition to the above-mentioned essential components, components to be added to the external preparation for skin and cosmetics, for example,
Oil agent, surfactant, powder, pigment, dye, water-soluble polymer,
An ultraviolet absorber, an antiseptic, a fragrance, etc. can be added within a range that does not impair the effects of the present invention.

The present invention can be applied to dosage forms such as creams, milky lotions, lotions, beauty essences and foundations which are usually used as cosmetics.

[0012]

Next, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto.

Examples 1 to 5 and Comparative Examples 1 to 5 Emulsions having the compositions shown in Tables 1 and 2 below were prepared by a conventional method, and (a) a sticky feeling, (b) a moist feeling, and (c) ) The goodness of spread was evaluated. Table 3 shows the evaluation results. In the examples and comparative examples,% means% by weight.

[0014]

[Table 1]

[0015]

[Table 2]

(Manufacturing Method) A. Components (1) to (3) are stirred at 70 ° C. B. Components (4) to (10) stirred at 70 ° C. were gradually added to A and cooled to room temperature to obtain an emulsion.

(A) Sticky feeling (Evaluation method) Ten test panels were used and Examples 1 to 5 were used.
The samples of Comparative Examples 1 to 5 were applied to the face in an appropriate amount, and the stickiness of each sample was evaluated using the following evaluation criteria (a). The average value of the scores for each sample was evaluated according to the following evaluation criteria (b).

[0018]

(B) Moist feeling (Evaluation method) Ten test panels were used and Examples 1 to 5 were used.
And an appropriate amount of the samples of Comparative Examples 1 to 5 was applied to the face, and the moist feeling felt in each sample was evaluated according to the following evaluation criteria (c).
Was used to give a rating. The average value of the scores for each sample was evaluated according to the following evaluation criteria (d).

[0020]

(C) Good spreadability (Evaluation method) Ten test panels were used, and Examples 1 to 5 were used.
The samples of Comparative Examples 1 to 5 were applied to the face in an appropriate amount, and the spread on the skin of each sample was rated using the following evaluation criteria (e). The average value of the scores for each sample was evaluated according to the following evaluation criteria (f).

[0022]

[0023]

[Table 3]

As is clear from the results of Table 3, Examples 1 to 5 of the present invention spread well when applied on the skin,
It had an excellent moist feeling and a good feeling of use with reduced stickiness.

Example 6 Emulsion (component) (%) 1. Hydrogenated soybean phospholipid 2.5 2. Cholesterol 0.5 3. Methyl polysiloxane (10 cs) 3.0 4. Glycerin 6.5 5. 1,3-butylene glycol 16.0 6. Carboxyvinyl polymer 0.2 7. Sodium hydroxide suitable amount 8. Preservative appropriate amount 9. Appropriate amount of fragrance 10. Purified water balance

(Manufacturing Method) A. Components (1) to (4) are stirred at 70 ° C. B. Components (5) to (10) stirred at 70 ° C. were gradually added to A and cooled to room temperature to obtain an emulsion. Example 6 has good stability and an excellent moist feeling,
It was a milky lotion that spreads well and has a non-sticky feel.

Example 7 Lotion (Component) (%) 1. Hydrogenated soybean phospholipid 0.4 2. Cholesterol 0.1 3. Methyl polysiloxane (6cs) 1.0 4. Liquid paraffin 1.0 5. Glycerin 2.0 6. Dipropylene glycol 15.0 7. Ethanol 3.0 8. Preservative appropriate amount 9. Appropriate amount of fragrance 10. Purified water balance

(Manufacturing Method) A. Components (1) to (6) are stirred at 70 ° C. B. Components (8) to (10) stirred at 70 ° C. were gradually added to A, and after cooling to room temperature, (7) was added to obtain a lotion. Example 7 was a lotion having a good stability, an excellent moisturizing feel, a refreshing and non-greasy feeling on use.

Example 8 Cream (ingredient) (%) 1. Decamethylcyclopentasiloxane 15.0 2. Methyl polysiloxane (10cs) 15.0 3. Polyoxyethylene methyl polysiloxane 2.0 4. Hydrogenated egg yolk phospholipid 0.2 5. Cholesteryl oleate 0.1 6. Glycerin 5.0 7. 1,3-butylene glycol 9.0 8. Preservative appropriate amount 9. Appropriate amount of fragrance 10. Purified water balance

(Manufacturing Method) A. Components (1) to (7) are stirred at 70 ° C. B. Components (8) to (10) stirred at 70 ° C. were gradually added to A and cooled to room temperature to obtain a cream. Example 8 has good stability and excellent moist feeling,
The cream spreads well and has a non-greasy feel.

Example 9 Liquid Foundation (%) 1. Stearic acid 2.0 2. Liquid paraffin 3.0 3. Decamethylcyclopentasiloxane 7.0 4. Methyl polysiloxane (6cs) 3.0 5. Liquid lanolin 1.0 6. Talc 3.0 7. Titanium oxide 5.0 8. Red iron oxide 0.5 9. Yellow iron oxide 1.4 10. Black iron oxide 0.1 11. Bentonite 0.5 12. POE sorbitan monostearate 0.5 13. Hydrogenated egg yolk phospholipid 0.5 14. Cholesteryl hydroxystearate 0.5 15. Triethanolamine 2.0 16. Propylene glycol 5.0 17. Preservative appropriate amount 18. Perfume proper amount 19. Purified water balance

(Manufacturing Method) A. Components (1) to (5) are stirred at 70 ° C. B. Components (12) to (19) stirred at 70 ° C. are gradually added to A. C. Components (6) to (11) that had been sufficiently mixed and pulverized were added to B and mixed, and the mixture was cooled to room temperature to obtain a liquid foundation. Example 9 was a liquid foundation having good stability, excellent moisturizing property, good spreadability, and non-greasy feeling in use.

[0033]

INDUSTRIAL APPLICABILITY According to the present invention, each component of phospholipid, cholesterol and / or its derivative, and silicone oil is blended in a specific amount, so that the safety to the skin is good and the stability is good. A skin external preparation having excellent moisturizing effect and emollient effect, good spreadability, and reduced unpleasant feeling such as stickiness can be obtained.

Claims (1)

[Claims] 1. The following components (A), (B) and (C) (A) phospholipid 0.05 to 5.0% by weight (B) cholesterol and / or its derivative 0.05 to 5.0% by weight % (C) Silicone oil 0.1 to 80% by weight, and the component ratio of (A) / (B) is 10/1 to 1
The external preparation for skin is characterized in that it is in the range of / 1, and (C) / {(A) + (B)} is 0.2 or more.