JPH09110673A - Bathing agent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition, which is applied to the body by means of coating or patching before bathing and gives the skin dampishness and freshness and youthfulness, by compounding a plant of pepper family, inorganic salt and oily substance. SOLUTION: This composition contains a plant of pepper family (e.g. Piper nigrum L, Piper longum L, Piper angustifolium R. et P., etc.), inorganic salt (e.g. sodium chloride, etc.), and oily substance (e.g. myristic glyceride, etc.), and furthermore, preferably a water-soluble polymer (e.g. gum arabi, etc.). Furthermore, the composition contains preferably a xanthine derivative such as aminophylline, theophylline, etc., β-adrenergic stimulant such as isoproterenol, dobutamine, etc., α2 -adrenergic depressant such as yohimbine, phentolamine, etc., and bipyridine derivative such as amurinone, myrurinone, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a bath agent composition having an excellent effect of imparting a moist feeling and a freshness to the skin.

[0002]

2. Description of the Related Art Bathing has various effects such as cleansing the body, warming not only the hands and feet to the core, and relaxing mentally, and is essential for daily life.

Conventionally, bath agents have been used for the purpose of obtaining various effects during bathing. Particularly, a bath agent containing a moisturizer for the purpose of suppressing the dryness of the skin after bathing in the winter season and fatigue. Bath agents containing various hot spring ingredients have been developed for the purpose of recovery and improvement of warmth.

[0004]

However, many of the conventional bath agents containing the above moisturizers and hot spring ingredients do not always give a pleasant feeling such as sticky skin during or after bathing. . Further, it has been desired to develop a bath agent composition having an excellent effect of imparting a moisturizing feeling and a freshness to the skin.

[0005]

Under such circumstances, as a result of intensive investigations by the present inventors, as a result, a bath composition containing a pepper plant, an inorganic salt and an oily component was
The present invention has been completed by finding that it is excellent in the effect of imparting a moisturizing feeling and freshness to the skin.

That is, the present invention provides a bath agent composition containing a pepper plant, an inorganic salt and an oily component.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Pepperaceae plants used in the present invention include pepper ( Piper nigrum L.) and hihatsu ( P.
iper longum L.), Soda ( Peperomia japonica Mak)
ino), sesame show ( Peperomia buninsimensis Makin)
o), P. persicae ( Peperomia caperata R.
et P.), Watageaoisou (Peperomia incana A. Die
tr.), White blue water ( Peperomia magnolifolia)
A. Dietr. Var variegata R.et P.), Green mackerel ( Peperomia puteolata Trel.), Green grass ( P.
eperomia sandersii C. DC.var argyreia Bailey),
Betel ( Piper betle L.), Piper cubeba
L.), Hippopotamus ( Piper methysticum Forst), Javan Nagagosho ( Piper retrofractum Vahl), Nantogosho ( Piper aurantiacum Wall var hupehense C. D
C.), Futokazura ( Piper kadzura Ohwi), Pipper Boehmerie Forium Wall ( Piper boehmeriae
folium Wall), Pipper Heinanese Hemul ( Piper
hainanense Hemsl), Pipper Howsei Maxim. ( P
iper haucei Maxim.), Piper sarmentosum Roxb., Mateico ( Piper angu
stifolium R. et P.) and the like. Among these, pepper, hihatsu and mateiko are particularly preferable.

Fruits, pericarps, seeds, leaves, petioles, branches, roots, flowers and the like are used as raw materials for such pepper plants, and among them, fruits, pericarps and leaves are preferable.

The Pepperaceae plant in the present invention is used as a raw material, as a juice, a dry powder, a solvent extract or the like.

Examples of the solvent extract include those extracted with water or an organic solvent such as lower alcohol and polyol, or a mixed solvent thereof, which is appropriately concentrated,
It is used after purification, sterilization and drying.

[0012] These pepper plants can be used alone or in combination of two or more kinds.
0.005 in the bath agent composition of the present invention in terms of solvent-extracted dry matter
Weight% (hereinafter, simply indicated as "%") or more, especially 0.01 to 20
% Is preferable.

In the bath agent composition of the present invention, the effect of imparting a moisturizing feel and freshness to the skin is realized by using the above pepper plant in combination with an inorganic salt and an oily component.

The inorganic salts used in the present invention include sodium chloride, sodium hydrogen carbonate, sodium carbonate,
Borax, sodium sulfate, sodium sulfide, sodium sesquicarbonate, sodium nitrate, sodium thiosulfate, sodium polyphosphate, sodium phosphate, calcium oxide, magnesium oxide, calcium carbonate, magnesium carbonate, potassium chloride, potassium sulfide, aluminum sulfate, sulfuric acid Examples thereof include aluminum potassium, and among these, sodium chloride, sodium hydrogen carbonate, sodium carbonate, sodium sulfate, sodium sesquicarbonate, magnesium oxide, calcium carbonate and magnesium carbonate are preferable. These inorganic salts can be used alone or in combination of two or more.

The content of the inorganic salt is preferably 5% or more, more preferably 10% or more in the bath agent composition of the present invention.
And 0.25 to 20,000 times the weight of pepper plants, especially
The amount is preferably 0.5 to 10,000 times.

As the oily component used in the present invention, oils and fats, waxes, hydrocarbons, higher fatty acids having 10 or more carbon atoms, higher alcohols, esters, essential oils, terpene compounds, silicone oils, etc. Is mentioned.

Examples of fats and oils are soybean oil, nuka oil,
Jojoba oil, avocado oil, almond oil, olive oil, cacao oil, sesame oil, persic oil, castor oil, coconut oil, mink oil, natural fats and oils such as beef tallow, lard, and hydrogenated oils obtained by hydrogenating these natural fats and oils. And synthetic triglycerides such as myristic acid glyceride and 2-ethylhexanoic acid triglyceride. Examples of waxes include carnauba wax, whale wax, beeswax, and lanolin. Examples of hydrocarbons include liquid paraffin, petrolatum, paraffin, microcrystalline wax, ceresin, squalane, blistane and the like. Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid. Examples of higher alcohols include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol and 2-hexyldecanol. As the esters, cetyl octanoate, triglyceride octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, octyldodecyl myristate,
Isopropyl palmitate, isopropyl adipate,
Examples thereof include butyl stearate, decyl oleate, cholesterol isostearate, and polyoxyethylene sorbite fatty acid ester. As essential oils, peppermint oil, jasmine oil, show brain oil, cypress oil, spruce oil,
Ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, chive oil, pine oil, lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose Examples thereof include oil and sage oil. Examples of the terpene compound include menthol, cineol, eugenol, citral, citronellal, borneol, linalool, geraniol, camphor, thymol, spilanthol, pinene and limonene. Examples of silicone oils include dimethylpolysiloxane.

Among these oily ingredients, myristic acid glyceride, 2-ethylhexanoic acid triglyceride, lanolin, liquid paraffin, petrolatum, paraffin, microcrystalline wax, squalane, lauric acid,
Myristic acid, palmitic acid, linoleic acid, linolenic acid, isostearic acid, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, cetyl octanoate, triglyceride octanoate, octyldodecyl myristate, isopropyl myristate,
Cholesterol isostearate, polyoxyethylene sorbite fatty acid ester, peppermint oil, spruce oil, cinnamon oil, rose oil, menthol, cineole, eugenol, citral, citronellal, geraniol, pinene, limonene, and dimethylpolysiloxane are preferable. These oily components can be used alone or in combination of two or more.

The blending amount of the oily component can be appropriately selected according to the dosage form (form) of the bath agent composition of the present invention, and usually 0.1 to 95% is preferable in the total amount of the composition,
In addition, it is preferably 0.005 to 19,000 times by weight, especially 0.005 to 9,500 times by weight, based on the pepper family plant.

The bath agent composition of the present invention may further contain a water-soluble polymer, whereby the effect of imparting a moisturizing feel and freshness to the skin is further enhanced. As the water-soluble polymer, sodium alginate, propylene glycol alginate, gum arabic, xanthan gum, carrageenan, locust bean gum, tara gum, tamarind gum, pectin, tragacanth, carboxymethylcellulose, carboxymethylcellulose sodium, hydroxypropylcellulose, methylcellulose, carboxyvinyl. Examples include polymers, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soy protein, gelatin, egg protein, casein sodium, whey protein, and the like. Among them, gums such as gum arabic and xanthan gum, sodium caseinate, sodium alginate, etc. Water-soluble protein, polyethylene glycol, polyvinyl alcohol Such as Le is preferable. These water-soluble polymers can be used alone or in combination of two or more.

The amount of the water-soluble polymer compounded can be appropriately selected according to the dosage form (form) of the bath agent composition of the present invention, and is usually 0.1 to 95% in the total amount of the composition. It is preferably 0.005 to 19,000 times by weight, more preferably 0.005 to 9,500 times by weight, based on the pepper plant.

If desired, the bath agent composition of the present invention may contain a dispersing / emulsifying agent for dispersing / emulsifying the oily component. The dispersing / emulsifying agent acts to prevent the oily components in the bath agent from floating on the water surface when the bath agent is dissolved in the bath water, and also makes the bath water cloudy, and the transparency of the 0.01% aqueous solution is 40 cm or less, If it is preferably 20 cm or less, it can give a high-class image like a milk bath.

Examples of such dispersion / emulsifiers include the water-soluble polymers described above, and surfactants.

As the surfactant, any of anionic, cationic, nonionic, natural and synthetic surfactants can be used, but in consideration of skin irritation, the nonionic one should be used. Is preferred. As the nonionic surfactant, for example, glycerin fatty acid ester,
Propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, tetraoleic acid polyoxyethylene sorbit, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid Esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester and the like can be mentioned.

These dispersion / emulsifiers can be used alone or in combination of two or more kinds, and the blending amount thereof is preferably 5 to 100% with respect to the oily component.

The bath composition of the present invention may further contain one or more selected from xanthine derivatives, β-adrenergic stimulants, α ₂ -adrenergic inhibitors and bipyridine derivatives, which may be used in combination. By doing so, the effect of giving the skin a moist feeling and freshness is further enhanced.

The xanthine derivative used in the present invention is not particularly limited, and examples thereof include compounds represented by the following general formula (1) and pharmacologically acceptable salts thereof.

[0027]

Embedded image

[In the formula, R ¹ represents a hydrogen atom or a methyl group, and R ² represents a hydrogen atom, a C 1 -C 2 hydroxyl group or a C ² -C 10 alkanoyl group which may be substituted. ~ 12 alkyl groups are shown. ]

Examples of such xanthine derivatives include xanthine, aminophylline, theophylline, choline theophylline, caffeine, theobromine, oxtriphylline, diprophylline, proxyphylline and pharmacologically acceptable salts thereof. Examples of the pharmaceutically acceptable salt include acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts and the like. Of these, aminophylline, theophylline, caffeine and their pharmacologically acceptable salts are particularly preferable. Further, as these xanthine derivatives, those synthesized or those substantially isolated from plants such as tea leaves can be used.

These xanthine derivatives can be used alone or in combination of two or more, and the blending amount thereof is 0.05% or more, particularly 0.1 to 2 in the bath agent composition of the present invention.
It is preferably set to 0%.

The β-adrenergic stimulant used in the present invention is not particularly limited and examples thereof include isoproterenol, epinephrine, norepinephrine, dobutamine, dopamine, butopamine, salbutamol, terbutaline, isoethalin, protoxylol, fenoterol, metaproterenol, Chlorprenaline, hexoprenaline, trimethoquinol, procaterol hydrochloride, prenalterol, forskolin, disodium (R, R) -5- [2-[[2- (3-chlorophenyl) -2-hydroxyethyl] -amino] Propyl]
-1,3-benzodioxole-2,2-dicarboxylate, (R
^* , R ^* )-4- [2-({2-[(3-chlorophenyl) -2-hydroxyethyl] amino} propyl) phenyl] phenoxyacetic acid, {2-
Hydroxy-5- [2-({2-hydroxy-3- [4- (1-methyl-4-trifluoromethyl) -1H-imidazol-2-yl] phenoxy} propyl) amino] ethoxy} benzamide monomethanesul Phonate, Erythro-DL-1- (7-methylindan-4-
Iloxy) -3-isopropylaminobutan-2-ol, pharmacologically acceptable salts thereof and the like can be mentioned. Examples of the pharmacologically acceptable salt include those similar to the above. Of these, isoproterenol, dobutamine,
Salbutamol and pharmaceutically acceptable salts thereof are preferable, and in this case, hydrochloride and sulfate are preferable.

These β-adrenergic stimulants can be used alone or in combination of two or more, and the compounding amount thereof is 0.005% or more, particularly 0.01 to 20% in the bath agent composition of the present invention. It is preferable that

The α ₂ adrenergic inhibitor used in the present invention is not particularly limited, and examples thereof include yohimbine, phentolamine, phenoxybenzamine, trazoline, ergotamine, ergotoxin, dihydroergotamine, ergomethrin, methylergomethrin, dihydroergotoxin, lauorcin. , Piperoxane, and pharmacologically acceptable salts thereof. Examples of the pharmacologically acceptable salt include those similar to the above. Of these, yohimbine, phentolamine, ergotamine, and pharmacologically acceptable salts thereof are preferable, and in this case, a mesylate salt, a tartrate salt, and a hydrochloride salt are preferable.

These α ₂ adrenergic inhibitors are
They may be used alone or in combination of two or more, and the blending amount thereof is preferably 0.005% or more, particularly 0.01 to 20% in the bath agent composition of the present invention.

The bipyridine derivative used in the present invention is not particularly limited, and examples thereof include compounds represented by the following general formula (2) and pharmaceutically acceptable salts thereof.

[0036]

Embedded image

[In the formula, R ³ represents a hydrogen atom or an alkyl group such as a methyl group and an ethyl group, and Q represents NH ₂ , NC and H ₂ N.
Indicates CO and the like. ]

Examples of such bipyridine derivatives include amrinone, milrinone, 5-cyano- [3,4'-bipyridine]-
6 (1H) -one, 5-carbamine- [3,4'-bipyridine] -6 (1H)-
On, and pharmacologically acceptable salts thereof.
Examples of the pharmacologically acceptable salt include the same as those mentioned above. Of these, amrinone, milrinone and pharmacologically acceptable salts thereof are preferable.

These bipyridine derivatives can be used alone or in combination of two or more, and the blending amount thereof is 0.005% or more, particularly 0.01% or more in the bath agent composition of the present invention.
It is preferable to be 20%.

The bath agent composition of the present invention may further contain known bath agent raw materials exemplified below, which are usually used in bath agents, but the bath agent raw materials which can be blended are limited to these. Not a thing.

(A) Organic acids having 2 to 8 carbon atoms; succinic acid,
Fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid, etc. (b) Inorganic acids; boric acid, metasilicic acid, silicic anhydride, etc. (c) Herbal medicines: fennel, chamomile, ginkgo, psyllium, cinnamon, safflower, peony, ginger, iris, senkyu, touki, chimpi, soybean, valerian, juniper, spruce, peppermint, carrot, etc. (d) Dyes; yellow dye 4, blue dye 1, yellow dye (1), and other tar dyes specified in Appendices I and II of the Ministry of Health and Welfare,
Natural pigments recognized as food additives such as chlorophyll, riboflavin, crocin, safflower and anthraquinone. (e) Vitamins; vitamin A, vitamin C, vitamin D, vitamin E, etc. (f) Fragrances. (g) Others: sulfur, yunohana, mineral sand, mica powder, neutral clay,
Rice bran, bactericide, antiseptic, sequestering agent, protease,
Anti-inflammatory agents and other necessary ingredients for formulation.

The bath composition of the present invention comprises powders, granules, tablets, powders, granules, tablets, and the like, which are added to the essential pepper plant, inorganic salt and oily component, if necessary, by adding the above optional components.
It can be manufactured into various dosage forms such as liquids. The blending amount of these optional components is preferably in the range of 0 to 99% in the composition. It is also possible to add an appropriate amount of water in the range of 0.01 to 90% to the thus prepared bath agent composition of the present invention to increase the stability of the preparation or to make the preparation an emulsified form. .

Further, the bath agent composition of the present invention comprises a gel,
A form such as a cream, a pack, or a sheet may be applied or attached to the body to take a bath. In the case of such a form, components such as a thickener and a crosslinking agent can be blended in addition to the above components.

When the bath agent composition of the present invention is used by adding it to the bath water at the time of bathing, the amount used is such that the concentration of pepper plants in the bath water is 0.01 in terms of solvent-extracted dry matter. ~ 200p
The amount is preferably pm. This concentration is 0.01ppm
When it is less than 200 ppm, the skin cannot be given a moist feeling and freshness, and when it exceeds 200 ppm, the effect is not further improved.

When the bath agent composition of the present invention is applied or applied to the body for bathing, an appropriate amount may be applied or applied to the whole body immediately before bathing before bathing.

[0046]

EFFECTS OF THE INVENTION The bath agent composition of the present invention is excellent in the effect of giving a moist feeling and freshness to the skin.

[0047]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.

Production Example 1 100 g of dried fruits of pepper (Piper nigrum L.) were extracted with hot water by a conventional method, filtered, concentrated under reduced pressure, and then freeze-dried to obtain a black pepper extract.

Production Example 2 100 g of dried fruit of Hihatu (Piper longum L.) was extracted with hot water by a conventional method, filtered, concentrated under reduced pressure, and then freeze-dried to obtain a Hihatu extract.

Production Example 3 100 g of dried leaves of mateicho (Piper angustifolium Ruiz et Pavon) were extracted with a 30% aqueous ethanol solution by a conventional method, filtered, concentrated under reduced pressure, and then freeze-dried to obtain a mateicho extract.

Examples 1 to 8 and Comparative Examples 1 to 5 Powdery bath agent compositions having the compositions shown in Table 1 were prepared by a conventional method, and the moist feeling and the freshness of the skin were evaluated by the following test methods. Table 1 shows the results.

Moisturizing sensation of skin: The bath agent composition in the amount used per one time shown in Table 1 is put into a bathtub filled with 150 liters of hot water at 40 ° C. Ten minutes after the addition, each subject (n = 5) was allowed to bathe for 5 minutes after the hot water was sufficiently stirred, and the moist feeling of the skin was judged according to the following criteria and shown as the average score.

5 points: Very moist. 4 points: Quite moist. 3 points: Moist. 2 points: Somewhat moist. 1 point: equivalent to Sarayu.

Freshness of skin: The freshness of the skin of each subject was judged according to the following criteria, and indicated as the average score.

5 points: Very fresh. 4 points: Quite fresh. 3 points: Fresh. 2 points: Somewhat juicy. 1 point: equivalent to Sarayu.

[0056]

[Table 1]

From Table 1, the bath preparation compositions of Examples 1 to 8 in which the pepper plant, the inorganic salts and the oily component were mixed were compared with the bath preparation compositions of Comparative Examples 1 to 5 in which any one of them was not added. The skin is moisturized and fresh,
Further, it is understood that the effect is enhanced by the water-soluble polymer, xanthine derivative, β-adrenergic stimulant, α ₂ -adrenergic inhibitor and bipyridine derivative.

Example 9 Gel-like bath agent to be applied and used: A bath agent having the following composition was prepared by a conventional method.

[Table 2] (Components) (%) Pepper extract 2 Calcium carbonate 10 Liquid paraffin 10 2-Ethylhexanoic acid triglyceride 33 Polyethylene glycol (average molecular weight 400) 7 Polyoxyethylene (60) octyldodecyl alcohol ether 8 Sorbitol balance Perfume Suitable amount Total amount of dye 100

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical display location A61K 35/78 ADA A61K 35/78 ADAC

Claims (8)

[Claims] 1. A bath agent composition containing a pepper plant, an inorganic salt and an oily component. 2. The bath agent composition according to claim 1, further comprising a water-soluble polymer. 3. The bath agent composition according to claim 1, further comprising one or more selected from a xanthine derivative, a β-adrenergic stimulant, an α ₂ -adrenergic inhibitor and a bipyridine derivative. 4. The xanthine derivative is aminophylline,
The bath agent composition according to claim 3, which is selected from the group consisting of theophylline, caffeine and salts thereof. 5. The bath agent composition according to claim 3, wherein the β-adrenergic stimulant is selected from the group consisting of isoproterenol, dobutamine, salbutamol and salts thereof. 6. The bath agent composition according to claim 3, wherein the α ₂ adrenergic inhibitor is selected from the group consisting of yohimbine, phentolamine, ergotamine and salts thereof. 7. The bath agent composition according to claim 3, wherein the bipyridine derivative is selected from the group consisting of amrinone, milrinone and salts thereof. 8. The bath agent composition according to any one of claims 1 to 7, which is for applying or sticking to the body for bathing.