JPH0892074A - Plaster - Google Patents

Abstract

PURPOSE: To provide a plaster having improved anchoring property of a tacky adhesive layer to a substrate without giving undesirable effect on the tacky adhesive properties such as adhesiveness, tackiness and cohesivity and the stretchability of the substrate. CONSTITUTION: This plaster is produced by forming an undercoating layer composed of an ethyleneimine-modified acrylic polymer or a polyethyleneimine on one surface of a substrate and forming a tacky adhesive layer on the undercoating layer. An alkyl acrylate polymer is preferable as the tacky adhesive layer. A plaster for transcutaneous absorption therapy can be produced by including a drug in the tacky adhesive layer and the drug may be a crystalline or amorphous substance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch having excellent anchoring property, which can be applied to the skin surface to protect a wound or continuously administer a drug into the living body through the skin.

[0002]

2. Description of the Related Art In recent years, various tapes and the like using an adhesive have been developed as a patch for administering a drug into a living body through a skin surface.

In order to effectively release the drug from the patch to the skin surface and absorb it into the skin, it is necessary to raise the drug concentration to some extent. However, by increasing the drug concentration, the drug becomes supersaturated or crystallized in the adhesive, the anchoring property of the adhesive on the support is lowered, and when the adhesive is removed from the skin, the adhesive does not adhere to the skin surface. There is a problem of remaining in.

As a method for improving this problem, Japanese Unexamined Patent Publication No. Hei 2
As described in JP-A-212419, a pressure-sensitive adhesive layer is formed on a support on which a non-woven fabric, a woven fabric, or the like is laminated to improve anchoring property of the pressure-sensitive adhesive to the support and prevent adhesive residue from the adhesive. Patches have been proposed.

However, this patch does not cause a problem when the pressure-sensitive adhesive layer has a thickness capable of sufficiently covering the irregularities of the non-woven fabric or the woven fabric, but the pressure-sensitive adhesive layer containing the drug in consideration of the drug utilization rate. When thinned, the adhesive layer can not cover the unevenness of the non-woven fabric or woven fabric, and the adhesiveness to the skin decreases,
On the contrary, the adhesive residue on the skin may easily occur. Also,
Although it is possible to use an extremely thin non-woven fabric or woven fabric, the cost is high.

Further, in the case of an adhesive patch which is required to have elasticity for application to elbows and knees, a nonwoven fabric or a woven fabric can be laminated even if it is a support which is very elastic in a single layer. , The stretchability is significantly impaired.

Further, Japanese Unexamined Patent Publication (Kokai) No. 6-310559 proposes a technique for improving anchorage of a support and an adhesive layer by using an isocyanate compound as an undercoating agent on the surface of the support. However, since the isocyanate compound has an extremely short pot life, it requires means such as blocking water and controlling the reaction temperature at a low temperature, which makes the operation extremely complicated. Furthermore, since isocyanate compounds are highly reactive, depending on the type of adhesive or drug, they may undergo a crosslinking reaction with the adhesive to change the adhesive physical properties, or may cause a decomposition reaction with the drug. Requires extreme caution.

[0008]

An object of the present invention is to anchor an adhesive layer to a support without adversely affecting adhesive properties such as adhesiveness, tackiness, cohesive force and stretchability of the support. It is to provide a patch having improved properties.

[0009]

As a result of intensive studies, the present inventors have found that the present invention achieves the above object.

That is, the patch of the present invention comprises an undercoat layer made of an ethyleneimine-modified acrylic polymer or polyethyleneimine formed on one surface of a support, and an adhesive layer formed on the undercoat layer.

By forming an undercoat layer comprising an ethyleneimine-modified acrylic polymer or polyethyleneimine on one surface of the support, the above-mentioned problems of the prior art are solved and the anchoring property of the pressure-sensitive adhesive layer to the support is improved. It is possible.

The support used in the present invention is not particularly limited, but a plastic film is preferable, and specifically, polyester, nylon, polyethylene, polypropylene, ethylene-vinyl acetate copolymer, ethylene-ethyl acrylate copolymer, Polyvinyl chloride, polyvinylidene chloride, polytetrafluoroethylene, polyurethane,
Examples include single-layer or laminated films of polyamide, polyvinyl alcohol, and the like. In addition to the plastic film, a single metal foil film or a laminate film of a plastic film and a metal foil can be used.

Of the above supports, those having elasticity are preferable, and examples thereof include polyethylene, porous polyethylene,
Examples thereof include polyesters, ethylene-vinyl acetate copolymers, polyurethanes, porous polytetrafluoroethylene, and the like alone or in a laminated film.

The thickness of the support is usually 5 to 1000 μm,
The thickness is preferably 5 to 100 μm, and more preferably 10 to 50 μm in view of the balance of flexibility and sticking operability.

The ethyleneimine-modified acrylic polymer or polyethyleneimine used as the undercoat layer in the present invention plays an important role in improving the anchoring force in the present invention. The ethyleneimine-modified acrylic polymer in the present invention is a polymer in which an ethyleneimine ring-opening reaction unit is added and modified in the molecule of the acrylic polymer, and the ethyleneimine is reacted at the same time when the acrylic polymer is prepared. It can be obtained by post-reacting and modifying ethyleneimine with a preliminarily prepared acrylic polymer. As such an acrylic polymer, specifically, at least one kind of (meth) acrylic acid alkyl ester having an alkyl group having 1 to 13 carbon atoms, (meth) acrylic acid, itaconic acid,
Examples thereof include those obtained by copolymerizing at least one kind of α- or β-monoolefincarboxylic acid having a carboxyl group such as crotonic acid, maleic acid, maleic anhydride, and fumaric acid as an essential component. The alkyl group in the (meth) acrylic acid alkyl ester may be linear or branched.

If desired, one or more of the following copolymerizable monomers may be copolymerized. Sulfoxyl group-containing monomers such as styrenesulfonic acid, allylsulfonic acid, sulfopropyl (meth) acrylate, (meth) acryloyloxynaphthalenesulfonic acid, acrylamidomethylpropanesulfonic acid, (meth) acrylic acid hydroxyethyl ester, (meth) Hydroxyl group-containing monomers such as acrylic acid hydroxypropyl ester, (meth) acrylamide, dimethyl (meth)
Amide group-containing monomers such as acrylamide, N-butyl acrylamide, N-methylol (meth) acrylamide, N-methylol propane (meth) acrylamide,
Alkylaminoalkyl group-containing monomers such as (meth) acrylic acid aminoethyl ester, (meth) acrylic acid dimethylaminoethyl ester, and (meth) acrylic acid t-butylaminoethyl ester, (meth) acrylic acid methoxyethyl ester, (Meth) acrylic acid ethoxyethyl ester and other (meth) acrylic acid alkoxyalkyl ester, (meth) acrylic acid tetrahydrofurfuryl ester, (meth) acrylic acid methoxyethylene glycol ester, (meth) acrylic acid methoxydiethylene glycol ester, (meth ) Acrylic acid methoxy polypropylene glycol ester or other alkoxyl group (or ether bond in side chain) -containing (meth) acrylic acid ester, (meth) acrylonitrile, vinyl acetate, vinyl propionate N- vinyl-2-pyrrolidone, methyl vinyl pyrrolidone, vinyl pyridine, vinyl piperazine, vinyl piperidone, vinyl pyrimidine, vinyl pyrazine, vinyl pyrrole, vinyl imidazole, vinyl caprolactam, vinyl oxazole, vinyl monomers such as vinyl morpholine.

The above monomers can be copolymerized by a known polymerization method to obtain an acrylic polymer. However, from the viewpoint of anchoring property and ease of coating, the copolymerization ratio is alkyl (meth) acrylate. It is preferable that the ester / α- or β-monoolefincarboxylic acid is adjusted to 90 to 99/10 to 1 (% by weight), preferably the ratio of α- or β-monoolefincarboxylic acid to about 8% by weight.

It is preferable that the addition ratio of the ethyleneimine modification to the acrylic polymer is about 50 to 200 mol% with respect to the carboxyl group from the viewpoint of reactivity and anchoring property. In addition, in such ethyleneimine modification, 1,2-propyleneimine or 2
-Propylene imine and the like can be used as long as the effects of the present invention are not impaired.

On the other hand, polyethyleneimine is --CH ₂ CH ₂ NH
A polymer having a repeating unit of-in the present invention, the molecular weight is 10,000 or more, preferably 30,000.
It is preferable to use the one adjusted as described above. When the anchoring property to the support is due to the reaction with the active amino group in polyethyleneimine, the molecular weight is not limited, but when the reactivity with the active amino group is poor,
It is effective to use one having a sufficiently large molecular weight. That is, it is considered that various factors such as the cohesiveness inside the polymer and the film forming ability act. The upper limit of the molecular weight is not particularly limited as long as it can be diluted with a solvent at the time of coating on the support surface and can be coated.

Among the ethyleneimine-modified acrylic polymer or polyethyleneimine, the former concrete example is Polyment (trade name) K manufactured by Nippon Shokubai Co., Ltd.
X-CK200, KX-CK500, NK-100P
M, NK-200PM, NK-350, NK-380,
NK-307 or the like can be used. As a specific example of the latter, Epomin (trade name) SP manufactured by Nippon Shokubai Co., Ltd.
A series or P-1000 can be used, and these undercoating agents may be used alone or in combination of two or more kinds.

The undercoat layer made of the material, 0.005~1g / m ² in terms of solid content on one side of the support, preferably formed by coating in the range of about 0.005 to 0.5 / m ^2. When the coating amount is less than 0.005 g / m ² , the pot life becomes relatively short, about 1 month, and the anchoring property, which is an effect of the present invention, may not be expected to be sufficiently improved. On the other hand, if the coating amount exceeds 1 g / m ² , the adhesive physical properties of the pressure-sensitive adhesive layer may change, or the stretchability of the support may be impaired when a stretchable support is used. Also,
When a drug is contained in the pressure-sensitive adhesive layer, the release property of the drug may be affected.

Examples of the adhesive include natural rubber-based, synthetic rubber-based, acrylic-based, silicone-based, vinyl ether-based and vinyl ester-based adhesives, and preferably acrylic-based adhesives. More preferred is a pressure-sensitive adhesive made of an alkyl acrylate polymer.

The alkyl acrylate-based polymer is a polymer using an alkyl (meth) acrylate having an alkyl group having 4 or more carbon atoms, and in particular, from the viewpoint of easy crosslinking reaction, ) It is preferable to use a copolymer containing an alkyl acrylate as a main component.

Specific examples of the (meth) acrylic acid alkyl ester include a linear or branched alkyl group such as butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl. Examples thereof include (meth) acrylic acid alkyl ester which is a chain alkyl group, and these can be used alone or in combination of two or more. Further, if necessary, the (meth) acrylic acid alkyl ester having an alkyl group having a carbon number of 3 or less is replaced with a part of the (meth) acrylic acid alkyl ester having an alkyl group having a carbon number of 4 or more to perform copolymerization. You can also do it.

Examples of the monomer copolymerizable with the (meth) acrylic acid alkyl ester include (meth)
Monomers containing carboxyl groups such as acrylic acid, itaconic acid, maleic acid, maleic anhydride, styrene sulfonic acid, allyl sulfonic acid, sulfopropyl (meth)
Monomers containing sulfoxyl groups such as acrylate, (meth) acryloyloxynaphthalene sulfonic acid, acrylamidomethylpropane sulfonic acid, etc., Hydroxyl groups containing (meth) acrylic acid hydroxyethyl ester, (meth) acrylic acid hydroxypropyl ester, etc. , (Meth) acrylamide, dimethyl (meth) acrylamide, N-butylacrylamide,
Monomers containing amide groups such as N-methylol (meth) acrylamide, N-methylolpropane (meth) acrylamide, (meth) acrylic acid aminoethyl ester, (meth) acrylic acid dimethylaminoethyl ester, (meth) acrylic acid t -Monomers containing alkylaminoalkyl groups such as butylaminoethyl ester, (meth) acrylic acid methoxyethyl ester, (meth) acrylic acid ethoxyethyl ester, etc.
Acrylic acid alkoxyalkyl ester, (meth) acrylic acid tetrahydrofurfuryl ester, (meth) acrylic acid methoxyethylene glycol ester, (meth)
Acrylic acid methoxydiethylene glycol ester,
(Meth) acrylic acid ester having an alkoxyl group (or an ether bond in the side chain) such as (meth) acrylic acid methoxy polypropylene glycol ester, (meth)
Acrylonitrile, vinyl acetate, vinyl propionate,
Vinyl monomers such as N-vinyl-2-pyrrolidone, methylvinylpyrrolidone, vinylpyridine, vinylpiperazine, vinylpiperidone, vinylpyrimidine, vinylpyrazine, vinylpyrrole, vinylimidazole, vinylcaprolactam, vinyloxazole, and vinylmorpholine. These can be used alone or in combination of two or more kinds for copolymerization.

These copolymerizable monomers can be used for adjusting the anchoring force between the pressure-sensitive adhesive layer and the support and for improving the drug solubility in the case of containing a drug, and the copolymerization amount depends on the purpose. It can be set appropriately.

Among the above-mentioned acrylic acid alkyl ester-based polymers, the polymers which can be preferably used in the present invention include (meth) acrylic acid alkyl ester in which α- or a- as a carboxyl group-containing monomer exemplified above. It is desirable to use a copolymer obtained by copolymerizing at least one of β-monoolefin carboxylic acids as an essential component.

That is, the active amino group in the undercoat layer made of an ethyleneimine-modified acrylic polymer or polyethyleneimine forms an ionic bond or an amide bond with the carboxyl group in the pressure-sensitive adhesive layer to form a bond with the pressure-sensitive adhesive layer. It is presumed that good anchorability can be exhibited.

Further, since the active amino group in the undercoat layer usually has various chemical reactivities like the low molecular weight amine, it has reactivity with the active amino groups other than the above α- or β-monoolefincarboxylic acids. It is also possible to select the monomers that have. Examples of such a compound having reactivity with an active amino group include aldehydes, ketones, alkyl halides, isocyanates, thioisocyanates, compounds having an active double bond, epoxy compounds, cyanamide compounds, guanidine compounds, Monomers such as ureas, acids, acid anhydrides, and acyl halides.

The thickness of the pressure-sensitive adhesive layer is usually 10 to 20.
The thickness is 0 μm, preferably 10 to 80 μm, and more preferably 20 to 50 μm.

The drug that can be incorporated into the pressure-sensitive adhesive layer is not particularly limited as long as it has transdermal absorbability. Specifically, general anesthetics, hypnotics / sedatives, antiepileptics, antipyretic and analgesic / antiphlogistics, sedatives, neuropsychiatric agents, local anesthetics, skeletal muscle relaxants, autonomic nerve agents, antispasmodics, antiparkinson. Drugs, antihistamines, cardiotonics, arrhythmic drugs, diuretics, antihypertensives, vasoconstrictors, coronary vasodilators, peripheral vasodilators, arteriosclerotic drugs, cardiovascular drugs, respiratory stimulants, antitussive and expectorant drugs , Hormonal drug, external drug for purulent disease, analgesic / pruritic / astringent / anti-inflammatory drug, parasitic skin disease drug, hemostatic drug, gout treatment drug, diabetic drug, anti-neoplastic drug, antibiotic drug,
Chemotherapeutic agents, narcotics, etc. can be used.

The mixing ratio of the drug to the adhesive (solid content) can be arbitrarily set depending on the drug releasing ability of the adhesive, the type of drug, the pharmacological effect and the like. Preferably 10 to 70% by weight in the adhesive layer, more preferably 3
It is mixed in the range of 0 to 65% by weight.

The above reason is as follows. That is, the ratio of the compounded drug crystallizing or blooming to lower the anchoring property to the support varies depending on the individual drug. In the case of a drug with a low affinity for an adhesive, crystals will precipitate from about 10% by weight and the anchoring force will decrease. In the case of a drug with a high affinity, crystals will precipitate from about 30% by weight and the anchoring force will decrease. There is a case. Therefore, when the compounding ratio of the drug is less than 10% by weight, crystallization of the drug does not occur and the anchoring property hardly deteriorates. Therefore, the effect peculiar to the present invention is more prominent when the compounding ratio is 10% by weight or more and crystals are precipitated. On the other hand, if it exceeds 70% by weight, the pressure-sensitive adhesive layer shows almost no skin adhesiveness and the cost increases.

Further, a release assisting substance may be blended with the above drug. This substance can be simply defined as promoting the release of the drug to the body surface,
This has the function of improving the solubility and diffusion of the drug in the adhesive layer, as well as the water-retaining ability of the keratin, keratin softening, keratin penetration (looseness), penetration aid and pore opening. Functions as a drug, a function to improve transdermal absorbability such as a function to change the surface condition of the skin, or both of the above functions, or in addition to these functions, the drug effect is further enhanced. Those that also have the function of promoting drug efficacy are widely included.

Examples of such release aids are glycols (mainly drug solubility) such as diethylene glycol, propylene glycol and polyethylene glycol, oils and fats (mainly drug diffusion properties) such as olive oil, squalene and lanolin, and urea. , Polar derivatives such as urea derivatives such as allantoin (mainly water-retaining ability of keratin), dimethyldecylphosphoxide, methyloctylsulfoxide, dimethyllaurylamide, dodecylpyrrolidone, isosorbitol, dimethylacetamide, dimethylsulfoxide, dimethylformamide (mainly keratin) Penetration), salicylic acid (mainly keratin softening), amino acid (mainly penetration aid), benzyl nicotinate (mainly pore-opening agent), sodium lauryl sulfate (mainly function to change the interface condition of the skin), salocol (Good transdermal absorbability Combined with things), and the like.

Others: plasticizers such as diisopropyl adipate, phthalic acid ester, diethyl sebacate, hydrocarbons such as liquid paraffin, various emulsifiers, ethoxylated stearyl alcohol, oleic acid monoglyceride, caprylic acid monoglyceride, glycerin monoglyceride such as lauric acid monoglyceride. Examples thereof include esters, glycerin diesters, glycerin triesters or mixtures thereof, higher fatty acid esters such as isopropyl myristate and octyl palmitate, and higher fatty acids such as oleic acid and caprylic acid.

When other substances are blended in addition to the drug as described above, the total of the drug and the other substance should be within the above range.

The adhesive patch of the present invention may be produced by forming each layer by a conventionally used method, for example, an undercoat layer made of an acrylic polymer modified with ethyleneimine or polyethyleneimine on one surface on a support. Is formed by coating or printing, and the pressure-sensitive adhesive layer is formed by coextrusion or dry lamination.

Specifically, a solution for an undercoat layer consisting of an ethyleneimine-modified acrylic polymer or polyethyleneimine is applied to one surface of a support by means such as gravure printing and dried to form a separately prepared pressure-sensitive adhesive layer. By transferring onto it, the patch of the present invention can be obtained.

[0040]

As described above, the patch of the present invention forms an undercoat layer having a specific composition between the support and the pressure-sensitive adhesive layer used for conventional patches, and therefore, the patch It has good anchoring properties with the pressure-sensitive adhesive layer, and has the effect of not causing a phenomenon of adhesive residue on the skin surface when it is peeled off after being applied on the skin and used.

Since the patch of the present invention does not use a non-woven fabric or a woven fabric as a means for improving the anchoring property, it does not hinder the elasticity of the support and changes the physical properties (adhesive properties) of the adhesive. It does not let you.

Furthermore, since the ethyleneimine-modified acrylic polymer or polyethyleneimine used as the undercoat layer in the present invention exhibits extremely good storage stability, the patch of the present invention can be stored under ordinary storage conditions. it can.

[0043]

EXAMPLES Examples of the present invention will be shown below and will be described more specifically. In the following text, "parts" means "parts by weight".

Example 1 95 parts of acrylic acid 2-ethylhexyl ester as a monomer and 5 parts of acrylic acid were placed in a reaction vessel which had been sufficiently replaced with nitrogen, and benzoyl peroxide as a polymerization initiator was added with stirring. 0. to 100 parts of the above monomer.
Add 2 parts, adjust the stirring speed, adjust the outer bath temperature, add ethyl acetate as a diluting solvent dropwise, and control the polymerization reaction temperature (inner bath temperature) at 60 to 65 ° C for 8 hours. went.

After the lapse of 8 hours, the temperature of the inner bath was raised to 75 to 80 ° C. and aged for 10 hours to prepare an adhesive solution.

60 parts of lidocaine, which is a local anesthetic, was added to 40 parts of the solid content of the obtained adhesive solution, and a release liner (the surface of which was subjected to a release treatment so that the thickness after drying was 20 μm) was obtained. Coated polyester film) and dried to prepare a drug-containing pressure-sensitive adhesive layer.

On the other hand, a 12 μm-thick polyester film having one surface subjected to corona discharge treatment was used as a support, and 0.04 g / m of toluene solution of Polyment NK-307 (trade name, manufactured by Nippon Shokubai Co., Ltd.) was applied to the treated surface. ^An undercoat layer was formed by coating so as to be ² and drying. The drug-containing pressure-sensitive adhesive layer prepared above was transferred onto the surface of the undercoat layer of the support thus obtained to obtain the patch of the present invention.

Example 2 All the same as Example 1 except that the monomers used in Example 1 were replaced with 75 parts of acrylic acid 2-ethylhexyl ester, 22 parts of N-vinyl-2-pyrrolidone and 3 parts of acrylic acid. An adhesive solution was prepared by the operation of.

10 parts of diclofenac sodium, which is an anti-inflammatory analgesic, 30 parts of oleic acid monoglyceride and 1.5 parts of sodium hydroxide were added to 58.5 parts of the solid content of the obtained pressure-sensitive adhesive solution, followed by drying. Later thickness is 40 μm
Was coated on a release liner (polyester film having a surface subjected to a release treatment) so as to be dried and dried to prepare a drug-containing pressure-sensitive adhesive layer.

On the other hand, an ethylene / vinyl acetate copolymer having a thickness of 70 μm (content of vinyl acetate unit: 18% by weight) was used as a support, and Polyment NK-200PM was provided on one side of the copolymer.
An aqueous solution (trade name, manufactured by Nippon Shokubai Co., Ltd.) was applied at a concentration of 0.1 g / m ² and dried to form an undercoat layer. The drug-containing pressure-sensitive adhesive layer prepared above was transferred onto the surface of the undercoat layer of the support thus obtained to obtain the patch of the present invention.

Example 3 70 parts of acrylic acid isononyl ester as a monomer, 25 parts of N-vinyl-2-pyrrolidone, and 5 parts of acrylic acid were put into a reaction vessel sufficiently replaced with nitrogen and stirred. However, 2 parts of azobisisobutyronitrile as a polymerization initiator was added to 100 parts of the above monomer, and the polymerization reaction was performed by adjusting the stirring speed, adjusting the outer bath temperature, dropping ethyl acetate as a diluting solvent, and the like. The polymerization reaction was carried out for 6 hours while controlling the temperature (internal bath temperature) at 60 to 65 ° C.

After 6 hours, the temperature of the inner bath was raised to 75 to 80 ° C. and aging was continued for 4 hours to prepare an adhesive solution.

To 60 parts of the solid content of the obtained adhesive solution, 40 parts of isosorbide dinitrate, which is a coronary vasodilator, was added.
Parts were added, and a drug-containing pressure-sensitive adhesive layer was prepared by coating on a release liner (polyester film having a surface subjected to a release treatment) so that the thickness after drying was 20 μm and drying.

On the other hand, a 60 μm-thick porous polyethylene film was used as a support, and Epomin P-1 was provided on one side of this film.
000 (trade name, manufactured by Nippon Shokubai Co., Ltd.) isopropanol solution was applied to 0.01 g / m ² and dried to form an undercoat layer. The drug-containing pressure-sensitive adhesive layer prepared above was transferred onto the surface of the undercoat layer of the support thus obtained to obtain the patch of the present invention.

Example 4 After the support on which the undercoat layer was formed in Example 1 was stored for 1 month, the patch of the present invention was obtained in the same manner as in Example 1.

Comparative Example 1 A patch was prepared in the same manner as in Example 1 except that the undercoat layer was not formed on the support.

Comparative Example 2 A patch was prepared in the same manner as in Example 2 except that the undercoat layer was not formed on the support.

Comparative Example 3 A patch was prepared in the same manner as in Example 3, except that the undercoat layer was not formed on the support.

Reference Example 1 Example 2 was repeated except that a non-woven fabric (manufactured by Asahi Kasei Co., Ltd., trade name Bencotton, basis weight 18 g / m ² ) was laminated instead of the undercoat layer formed on the support.
A patch was prepared in the same manner as in.

Reference Example 2 In Example 1, the undercoat layer formed on the support was 0.7
Obtained by coating 5% by weight of a toluene solution of hexamethylene diisocyanate adduct of trimethylolpropane (trade name: Coronate HL, manufactured by Nippon Polyurethane Co., Ltd.), which is a trifunctional isocyanate, at 0.04 g / m ² and drying. Was replaced with a subbing layer. Furthermore, a patch was prepared in the same manner as in Example 1 except that this support was stored at room temperature for 1 month before use.

The following tests (measurements) were carried out on the patches obtained in the above Examples and Comparative Examples, and the results are shown in Table 1. In addition, about Example 2 and Reference Example 1, 5
The% modulus was measured.

<Adhesion test> Bakelite board with a width of 12 m
Attach each strip-shaped sample to m and load 850g
After reciprocating the roller of 1 times to bring it into close contact, 23 ° C, 60
% R. H. Under the conditions described above, peeling was performed in a 180 ° direction at a speed of 300 mm / min by a Tensilon tensile tester, and the peeling force at that time was measured.

<Anchoring Force Test> Placebo tape cut to 13 × 100 mm (tape prepared without adding drugs and additives from the patch prepared in each Example, Comparative Example, etc.)
Is fixed to a 25 x 100 mm bakelite plate with double-sided tape, and 12 x 70 mm is attached to the adhesive layer surface of the placebo tape.
Each sample cut into pieces was attached using a roller having a load of 850 g, and then at 23 ° C. and 60% R.S. H. 300mm in 90 degree direction by Tensilon tensile tester
Peeling was performed at a speed of / minute, and the load stress at that time was measured.

<Human Skin Sticking Test> Each sample cut into 30 × 50 mm was stuck on the back of a volunteer for 1 hour, then peeled off, and the state of anchorage destruction at that time was observed, and evaluated according to the following criteria. did.

○: Anchor is not destroyed. Δ: The edge part is slightly anchored and destroyed, and the adhesive remains on the back. ×: The anchor was destroyed and the adhesive remained on the back.

<Measurement of Modulus> Each sample was measured by JIS
Dumbell type No. 2 punched, 23 ℃, 60% R.C. H. Under the conditions of 300 mm /
The 5% modulus when pulled at the rate of minutes was measured.

[0067]

[Table 1]

As is apparent from Table 1 above, Examples 1 to 1
The adhesive patch of No. 3 has no difference in adhesive strength as compared with the corresponding adhesive patches of Comparative Examples 1 to 3, but has obviously superior properties in anchoring power and adhesiveness to human skin. Even if the undercoat layer is not formed unlike the patch of Reference Example 1, the anchoring force is obviously improved by laminating the non-woven fabric. However, by laminating a non-woven fabric, the stretchability of the support itself is lost, so that when it is attached to human skin, it gives a feeling of tension.

When the patch of Example 4 and the patch of Reference Example 2 are compared, the patch of Reference Example 2 has low anchoring property and Comparative Example 3
Almost the same as the (untreated) patch. Furthermore, when comparing the patches of Example 1 and Example 4, since they have almost the same adhesive force and anchoring force, Polyment NK-307 as an undercoating agent has a sticky physical property even after being stored for 1 month. It turns out that it is extremely stable without changing.

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Claims (3)

[Claims] 1. A patch comprising an undercoat layer comprising an ethyleneimine-modified acrylic polymer or polyethyleneimine formed on one side of a support, and an adhesive layer formed on the undercoat layer. 2. The patch according to claim 1, wherein the adhesive layer contains a drug. 3. The patch according to claim 2, wherein the drug in a crystalline state or an amorphous state is dispersed in the adhesive layer.