JPH08325467A - Aerosol composition for antibacterial coating - Google Patents

Abstract

PURPOSE: To obtain an aerosol compsn. which, when sprayed onto a wall in a room, an utensil or the like, can simply form a coating having an antibacterial activity, against a wide range of microorganisms, persistent for a long period of time. CONSTITUTION: This aerosol compsn. comprises an aerosol stock soln. comprising a water-ethanol mixed soln. having an ethanol content of 30 to 90wt.% and containing 0.5 to 5w/v% colloidal particles, with an average particle diameter of 5 to 20nm and comprising an antibacterial component of silver and an inorg. oxide other than silver bearing the antibacterial component, 0.5 to 10w/v% water-soluble polymer comps., and 2 to 10wt.% hydrophilic org. solvent, the aerosol stock soln. being filled together with a propellant into a spray container.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aerosol type antibacterial agent, and particularly to wall surfaces, floor surfaces, ceiling surfaces, and various surfaces for hygiene control in hospitals, food / pharmaceutical factories, public facilities, mass transportation means and the like. The present invention relates to an aerosol composition for applying a long-term antibacterial coating to the surfaces of furniture, fixtures, door knobs, handrails, etc.

[0002]

Prior Art and Problems to be Solved by the Invention MRS
Nosocomial infection with A (mesitillin-resistant Staphylococcus aureus) has become a major social problem in recent years, and various measures have been attempted to block the infection route. For example, antibacterial materials have been developed for interior materials such as wall surfaces, ceiling surfaces and floors, paints, floor waxes and the like.

However, it is not always easy to reapply the antibacterial interior material to the existing ceiling surface, wall surface, etc. because of the labor and cost. Further, the antibacterial interior material must be one whose antibacterial property does not decrease over time, and further,
Even if the interior material itself maintains the antibacterial property, when the surface is contaminated with a certain amount or more of dirt, the surface can be physically covered thereby to mask the antibacterial activity. Therefore, it cannot be said that the use of the antibacterial interior material is sufficient to prevent infection through the interior material, and regular maintenance is required to maintain the antibacterial property. For this, it is preferable that the surface is newly subjected to antibacterial treatment.

If the interior materials having antibacterial properties are not used, it is necessary to subject the interior materials to some antibacterial surface treatment. The same applies to furniture, fixtures, door knobs, handrails, etc.

The antibacterial surface treatment can be carried out by applying a coating material containing an antibacterial agent. However, as with the case of using an antibacterial interior material, periodical maintenance is required, so that it can be easily carried out. What can be done is preferable. There are organic antibacterial agents (due to the medicinal effects of antibacterial organic substances) and inorganic antibacterial agents (due to the bactericidal effect of metals such as silver, copper and zinc), but organic antibacterial agents are effective bacteria. The range tends to be relatively limited. In addition, it is desirable that the antibacterial activity be maintained for a sufficiently long period of time, but some antibacterial agents are subject to volatilization, elution, decomposition by microorganisms, etc. This tendency is also large in organic antibacterial agents.

[0006] Thus, the ceiling surface, wall surface,
There has been a demand for a means capable of easily applying a continuous, antibacterial-selective antibacterial coating to the surfaces of handrails, doorknobs, furniture and fixtures. The present invention provides an antibacterial coating aerosol composition capable of easily imparting a long-lasting antibacterial coating against a wide range of microorganisms to the interior surfaces of rooms, furniture, doorknobs, handrails, etc. by spraying them. The purpose is to provide.

[0007]

As an antibacterial component of such an antibacterial coating aerosol composition, an inorganic antibacterial component is used in order to exert antibacterial activity against a wide range of microorganisms and to maintain the antibacterial activity for a long period of time. Is preferably used. As the inorganic antibacterial component, silver is most preferable from the viewpoint of both efficacy and safety to human body, and it is preferable to use particles in which the inorganic antibacterial component is supported on a suitable carrier. Further, as a medium of the undiluted aerosol solution, a medium based on a mixed solution of water and ethanol is preferable in consideration of safety, influence on the coated surface, rapid drying due to spraying on the wall surface and the like. Containing ethanol is also preferable from the viewpoint of immediate bactericidal effect. Further, it is necessary to include a means for adhering the particles after spraying to the surface of the wall surface, furniture, etc. for a long period of time while maintaining the activity. The present inventor has found that the above object can be achieved by forming the following aerosol composition.

That is, according to the present invention, 0.5 to 5 w / v% of colloidal particles having an average particle size of 5 to 20 nm and comprising an antibacterial component made of silver and an inorganic oxide other than silver which carries the antibacterial component,
5-10 w / v% water-soluble polymer compound, 2-10% by weight
A hydrophilic organic solvent and an undiluted aerosol solution containing a water-ethanol mixture containing ethanol in the range of 30 to 90% by weight, and a spray container filled with a propellant, which is an antibacterial coating aerosol composition. is there.

The colloidal particles are preferably those in which an antibacterial component made of silver is supported on a carrier containing SiO ₂ and TiO _2, and may further contain other inorganic oxides. The amount of silver is preferably from 0.1 to 25% by weight, and particularly preferably from 0.1 to 15% by weight, based on the silver oxide, of the grains.

[0010] The colloidal particles are 0.5
It is preferably contained in an amount of ˜5 w / v%, particularly preferably in an amount of 1 to 2.5 w / v%.

The main purpose of containing the water-soluble polymer compound is to spray antibacterial particles of the present invention and then to attach antibacterial particles to the surfaces of walls, furniture, etc. for a long period of time while maintaining their activity. It is in. The water-soluble polymer compound is (1) synthetic resin such as water-soluble acrylic resin, water-soluble acrylic alkyd resin, water-soluble alkyd resin, water-soluble epoxy resin, water-soluble urethane resin, polyvinyl alcohol and its derivatives,
Synthetic water-soluble polymer compounds such as polyvinylpyrrolidone and its derivatives, (2) Cellulose derivatives such as hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose and sodium carboxymethylcellulose, (3) Water-soluble proteins and peptides such as casein and gelatin , (4) starch,
It is preferably selected from the group consisting of natural water-soluble polysaccharides such as sodium alginate, carrageenan, pectin, gum arabic and xanthan gum. Particularly preferred examples include those described in the examples, as well as casein, gelatin, polyvinyl alcohol, polyvinylpyrrolidone, starch, and cellulose derivatives. Further, the water-soluble polymer compound is preferably contained in the aerosol stock solution at a concentration of 0.5 to 10 w / v%, more preferably 1 to 8 w / v%, and particularly preferably 3 to 6 w / v%. include.

Examples of the hydrophilic organic solvent include ethylene glycol isobutyl ether, ethylene glycol monobutyl ether, isopropylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, and propylene glycol monoethyl ether. Are preferred, and these can be used alone or in combination. The hydrophilic organic solvent is contained in the aerosol concentrate in the range of 2 to 10 w / v%, more preferably 3%.
To 8 w / v%, more preferably 4 to 6 w / v%.

The aerosol stock solution may contain at least one of an antifoaming agent, a leveling agent, a rust preventive and a dryer known to those skilled in the art by a conventional method.

As the propellant, any propellant which is usually used in an aerosol may be used. For example, nitrogen gas, nitrous oxide gas, carbon dioxide, CFC substitute gas, liquefied petroleum gas, dimethyl ether, etc. may be used alone or in combination. You can do it.

When the aerosol composition for antibacterial coating of the present invention is used, it is preferable to first remove dust, dirt and the like on the surface to be antibacterial coating and dry the surface. In the case of antibacterial coating of wall surfaces, furniture and fixtures, doorknobs, etc. according to the present invention, the composition of the present invention is thinly and evenly dispersed on a dried surface of the wall surface and furniture so that each of the minute droplets does not connect to each other. It is preferable to spray the powder and then spray it again after drying. The reason why the droplets are dispersed and sprayed is to accelerate the drying. Spraying the aerosol composition of the present invention can provide a long lasting antimicrobial coating against a wide range of bacteria and molds including MRSA.

Antibacterial colloidal particles are disclosed in JP-A-7-33616.
It can be obtained according to the example of. That is, for example,
Titanium sulfate was dissolved in pure water to obtain TiO ₂ 1.0% by weight
An aqueous solution having a concentration of 15% by weight of ammonia water is gradually added with stirring to obtain a white slurry liquid, which is filtered and washed to obtain a hydrous titanic acid cake. After adding pure water and 219.8 g of 33 wt% hydrogen peroxide to 31.4 g of this cake, 80
Heated at 14 ℃ for 14 hours to prepare a 1.0 wt% solution of TiO _2.
3136 g are obtained (yellowish brown transparent pH about 8.2). Separately, 0.64 g of silver oxide was dissolved in ammonia water obtained by diluting 21.3 g of 15% by weight ammonia water with 618.1 g of pure water to prepare an aqueous solution of an ammine complex salt of silver, and 15.4 g of ammonium zirconium carbonate was added to this solution in an amount of 169.9 g of pure water. Add the one dissolved in. This mixed aqueous solution is added to the titanic acid solution, and then
Add 38.7 g of 20% by weight silica gel and heat at 150 ° C for 36 hours. This solution initially has a yellowish brown color, but after 36 hours, it becomes a pale milky white transparent colloidal solution. The pH of this colloidal solution is 7.5, the solid content concentration is 12.0% by weight, and the average particle size of the colloidal particles is 5.5 nm.

[0017]

【Example】

[Example 1] An aerosol stock solution is prepared according to the following formulation ratio. (Undiluted solution) Antibacterial particles (* 1) 20 g Water-soluble acrylic resin composition (* 2) 100 g Deionized water 435 g Ethanol 435 g Defoamer (* 3) 2 g Leveling agent (* 4) 3 g protection Rust agent (* 5) 5 g Total amount 1000 g (* 1) Atomie Ball (Catalyst Kasei Co., Ltd.) (* 2) Watersol S-753: Dainippon Ink and Chemicals, Inc. Consists of 50% resin solids, 24% ethylene glycol isobutyl ether, 12% ethylene glycol monobutyl ether, and 14% water. (* 3) L475: manufactured by Dow Chemical Co., Ltd. (* 4) BYK-0: manufactured by BYK-Chemie Japan Co., Ltd. (* 5) Sabine Elephant 2000: manufactured by Fuso Chemical Industry Co., Ltd.

The above stock solution is filled in a spray container by a conventional method together with nitrogen gas or dimethyl ether. The liquid phase of the aerosol composition is white and opaque and is 5.5 c at 20 ° C.
It has a viscosity of ps.

Example 2 An aerosol stock solution is prepared according to the following formulation ratios. (Undiluted solution) Antibacterial agent (* 1) 20 g Water-soluble acrylic alkyd Resin composition (* 6) 77 g Deionized water 445 g Ethanol 445 g Defoamer (* 3) 2 g Leveling agent (* 4) 3 g Rust agent (* 5) 5 g Dryer (* 7) 3 g Total amount 1000 g (* 6) Watersol S-346: Dainippon Ink and Chemicals, Inc. Consists of 65% resin solids and 35% ethylene glycol monobutyl ether. (* 7) High Cure MIX: Water-soluble cobalt, zircon, potassium dryer manufactured by Toei Kako Co., Ltd.

The above stock solution is filled in a spray container by a conventional method together with nitrogen gas or dimethyl ether. The liquid phase of the aerosol composition is white and opaque and is 5.5 c at 20 ° C.
It has a viscosity of ps.

Example 3 An aerosol stock solution is prepared according to the following formulation ratio. (Undiluted solution) Antibacterial agent (* 1) 20 g Water-soluble acrylic alkyd Resin composition (* 6) 40 g Ion-exchanged water 220 g Ethanol 713 g Defoamer (* 3) 1 g Leveling agent (* 4) 2 g Prevention Rust agent (* 5) 3 g Dryer (* 7) 1 g Total 1000 g

The above stock solution is filled in a spray container by a conventional method together with nitrogen gas or dimethyl ether. The liquid phase of the aerosol composition is white and opaque.

Example 4 An aerosol stock solution is prepared according to the following formulation ratios. (Undiluted solution) Antibacterial agent (* 1) 20 g Water-soluble alkyd resin composition (* 8) 100 g Deionized water 434 g Ethanol 433 g Defoamer (* 3) 2 g Leveling agent (* 4) 3 g Rust prevention Agent (* 5) 5 g Dryer (* 7) 3 g Total amount 1000 g (* 8) HARIDIP AD-103: manufactured by Harima Chemicals. Resin solid content 50% by weight, ethylene glycol monobutyl ether 33%, isopropylene glycol 8% by weight,
And 9% by weight of water.

The above stock solution is filled into a spray container together with nitrogen gas or dimethyl ether by a conventional method. The liquid phase of the aerosol composition is white and opaque and is 5.5 c at 20 ° C.
It has a viscosity of ps.

[Antibacterial Activity Test] The aerosol composition of Example 1 was sprayed on the test piece so that the droplets were not connected, left for 30 minutes to dry, and then sprayed again in the same manner and dried. Methicillin-resistant Staphylococcus aureus (MRS)
Add 50 μL each of the bacterial solution of A) (5.3 × 10 ³ viable cells each),
After standing at 28 ° C. for 6 hours and 24 hours, the viable cell count was measured and the mortality was calculated by the following formula.

[0026]

[Equation 1] Death rate = {(initial viable cell count-live cell count after leaving) / initial viable cell count} × 100

As a result, as shown in the following table, the MRS compared to the control which was not sprayed with the aerosol composition of the present invention.
It was confirmed that A was decreasing very quickly.

[0028]

[Table 1]

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display location C08K 3/22 KAE C08K 3/22 KAE C08L 1/00 LAA C08L 1/00 LAA 3/00 LAT 3 / 00 LAT 5/00 LAW 5/00 LAW 89/00 89/00 C09K 3/30 C09K 3/30 R

Claims (6)

[Claims] 1. Colloidal particles of 0.5 to 5 w / v% having an average particle diameter of 5 to 20 nm and 0.5 to 10 w / v% of a water-soluble substance, which comprises an antibacterial component made of silver and an inorganic oxide other than silver carrying the same. Polymer solution and 2 to 10% by weight of hydrophilic organic solvent in an aqueous ethanol mixture containing ethanol in the range of 30 to 90% by weight, and an aerosol stock solution is filled in a spray container together with a propellant. An aerosol composition for antibacterial coating, which comprises: 2. The composition according to claim 1, wherein the inorganic oxide contains SiO ₂ and TiO ₂ . 3. The amount of the antibacterial metal component is 0.1 to 25 of the particles.
The composition of claim 1 or 2 which is in weight percent. 4. The water-soluble polymer compound comprises (1) a water-soluble acrylic resin, a water-soluble acrylic alkyd resin, a water-soluble alkyd resin, a water-soluble epoxy resin, a synthetic resin containing a water-soluble urethane resin, polyvinyl alcohol and the like. Derivative,
A synthetic water-soluble polymer compound which may be polyvinylpyrrolidone and its derivatives, (2) a cellulose derivative which may be hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose and carboxymethylcellulose sodium, (3) casein, gelatin 4. A good water-soluble protein and peptide, (4) a natural water-soluble polysaccharide which may be (4) starch, sodium alginate, carrageenan, pectin, acacia and xanthan gum, and is selected from the group consisting of: Any composition. 5. The hydrophilic organic solvent is ethylene glycol isobutyl ether, ethylene glycol monobutyl ether, isopropylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether,
And a composition selected from the group consisting of and propylene glycol monoethyl ether. 6. The composition according to claim 1, which contains at least one of an antifoaming agent, a leveling agent, a rust preventive and a dryer.