JPH083021A - Hair growth stimulant - Google Patents

Abstract

PURPOSE:To obtain a hair growth stimulant having preventing effects on dandruff and alopecia and hair growing effects without any side effect by use thereof for a long period. CONSTITUTION:This hair growth stimulant contains an ethanol extract solution or a 1,3-butylene glycol extract solution of a KOJI (malted rice) and is obtained by fermenting a rice embryo bud or a rice bran with, e.g. a mold starter KOJI Aspergillus oryzae and extracting the resultant fermentation product with ethanol or 1,3-butylene glycol. The minimum mold inhibitory concentration of the resultant extract solution is 50000ppm for the ethanol extract solution and 50000ppm for the 1,3-butylene glycol extract solution. A change is not observed in the inhibitory concentration even after 2 years by a growth inhibition test with time.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention uses koji for ethanol or 1,
The present invention relates to a hair-growth material containing a koji extract obtained by extraction with 3-butylene glycol, which prevents dandruff and hair loss and promotes hair growth.

[0002]

2. Description of the Related Art It is estimated that there are more than 50 kinds of hair-growth agents that are generally known at present and hundreds of other names.

There are many medicinal substances used in hair restorers, and they are classified into plant type, chemically synthesized type, hormone type and the like. However, at present, there is almost no hair-growing agent that has a remarkable effect and has no side effects even after long-term use.

[0004]

DISCLOSURE OF THE INVENTION It is an object of the present invention to provide a novel hair-growth agent which has remarkable dandruff, hair loss preventing effect and hair-growth effect and has no side effect even when used for a long period of time.

The aging and generation cycle of normal cells is about 25
It is said to be ~ 28 days, and this causes keratinization and dandruff every day, and cell generation and aging are repeated.

When dandruff develops, it causes itchiness, which blocks hair roots and sebaceous glands to suppress cell division of hair milk and inhibits hair growth to cause hair loss. In addition, when the hair of the hair is inhibited, the capillaries cannot supply nutrition, and the hair loss symptoms are promoted. Therefore, the present invention prevents excessive dandruff and hair loss,
In order to promote hair growth, it is basically the first consideration to prevent aging and keratinization of living cells, and for that purpose it is important to maintain scalp hair cleanliness and prevent keratinization. After investigating what is the main cause of dandruff, it was found to be bacteria and fungi.

When the koji extract of the present invention was applied to the scalp, the growth of mold, which is the main cause of dandruff, was stopped,
It was found to maintain normal scalp cleanliness and promote hair growth.

The present invention is a hair-growth agent containing an ethanol or 1,3-butylene glycol extract of koji, which is, for example, rice germ or rice bran, which is subjected to koji fermentation with seed koji Aspergillus oryzae to prepare ethanol or 1,3. Obtained by extraction with 3-butylene glycol. As the koji raw material, any starchy substances such as rice, wheat, buckwheat, etc., and their starch-containing substances such as germs and bran can be used.

By using this extract, dandruff and hair loss can be prevented and hair growth can be promoted.

The minimum inhibitory concentration of filamentous fungi in the koji extract of 1,3-butylene glycol of the present invention is 50,000 p.
The koji extract with ethanol is 5,000
Since it was ppm, no change was observed in the inhibitory concentration even after 2 years in the growth inhibition test over time, and it was proved that the extract was stable.

The measurement method and the results of the minimum inhibitory concentration (MIC) of Trichophyton in the rice bran-embryo ethanol extract according to the present invention are as follows.

[Method and Results] 10 ml of rice bran-rice germ ethanol extract was concentrated under reduced pressure about 5 times, and then sterile distilled water was added to make 10 ml. The solution was further serially diluted with sterilized water and put into a sterile petri dish. After adding sterilized potato dextrose agar medium kept at 50 ° C and mixed well to solidify, Trichophyton mentagrophy (Trichophyton mentagrophy)
tes IFO5466) spore suspension (3 platinum loops of slope-cultured cells were suspended in 10 ml of sterilized 0.005% sodium dioctylsulfosuccinate, and hyphae were filtered off with cotton) to apply 27 The temperature was kept at 0 ° C and the growth of bacteria was examined.
As a result, the minimum inhibitory concentration (MIC) was 5,000.
It was ppm. The progress of the test is shown in Table 1. In the table, + means growth, and-represents no growth.

[0013]

[Table 1]

The present invention will be described below with reference to Reference Examples and Examples. (Reference Example 1) Manufacturing method of koji 300 g of rice germ and 350 g of purified water were added to 700 g of rice bran and stirred, and heat treatment was performed at 105 to 110 ° C for 20 minutes in an evaporator to inactivate sterilization and various enzymes such as lipase. Then, the oxidation of the contained fat is stopped. The residual starch quality and the germinative starch quality are pregelatinized and fermented with Aspergillus oryzae for koji to grow Aspergillus oryzae and saccharify the starch. The fermentation time is optimally 72-94 hours, the koji medium should be neutral and not more acidic than pH 6.0.

The reason is that the medium is lactic acid or the like at a pH of 2.5 to
This is because when fermented to 3.5, skin irritation occurs and the production of koji acid, which is an unnecessary substance for the present invention, is observed.

The presence or absence of koji acid in the koji extract is 1% in the extract.
When iron (III) chloride is added dropwise, it turns out to appear red.

The results of measuring the components of koji are as shown below.

Moisture 9.1% Ash (residual heat residue) 11.2% Crude protein (total nitrogen x 6.25) 16.2% Crude fat (ether solubles) 20.5% Crude fiber 10.2 Soluble nitrogen-free (sugar) 32.8% Arsenic is not detected Heavy metal (as lead) 1ppm or less Soluble nitrogen-free is 100% water, ash, crude protein,
The values are shown by subtracting the amounts of crude fat and crude fiber. Reference Example 2 The koji obtained in Reference Example 1 is extracted with 95% ethanol 75% and purified water 25%, and the ethanol extract of koji has the following characteristic values and properties.

Demonstration value Specific gravity 0.91 Refractive index 1.369 pH 6.8 Acid value 1.1 Arsenic not detected Heavy metal 0.1 ppm or less Water 31.5 Ethanol 64.3 Total nitrogen 0.18 Iron chloride (III ) No color change with liquid.

A white turbidity is produced by dropping of purified water.

No color develops when iodine is added. (Reference Example 3) The 1,3-butylene glycol extract of koji is a liquid having a pale yellow fragrance, and its characteristic values and properties are as follows.

Demonstration value Specific gravity 1.035% Refractive index 1.3729 pH 6.0 Acid value 2.1 Arsenic not detected Heavy metal 0.03 ppm Iron (III) chloride No coloration.

White turbidity occurs when 95% ethanol is added dropwise.

A white turbidity is formed by dropping of purified water.

No color develops when iodine is added.

[0026]

【Example】

Koji ethanol extract obtained in Reference Example 1 2.0% Fragrance 0.2% 95% Ethanol 47.8% Purified water 50.0% are mixed at room temperature to contain a koji ethanol extract. Got

[0027] This hair-growth agent was applied to a wide range of people, including hair-dressing and beauty-related people 70, hospital-related people 28, office-related company officials 60, chemical technicians 125, and a total of 283 people.
When dandruff and hair loss after 3 weeks were investigated, 198 of 283 survey requesters answered, and the results were as shown below. .

No dandruff generation 182 people Hair loss decreased 144 people The above values are surprisingly high values, and the effects have been continuously investigated. The effects of dandruff, hair loss prevention, and hair growth promotion are not found. Under the present circumstances, a value close to 100% is obtained.

[0029]

EFFECTS OF THE INVENTION When the hair-growing material of the present invention is used, it is possible to prevent the occurrence of dandruff in 2-3 times, hair loss is reduced in 4-5 days, and hair growth is promoted. However, there is no side effect, and rather, gray hair gradually becomes black, which is an epoch-making effect as a hair-growth material.

Claims (2)

[Claims] 1. A hair restorer containing an ethanol extract of koji. 2. A hair restorer containing a 1,3-butylene glycol extract of koji.