JPH08299923A - Washing method and washer - Google Patents

Abstract

PURPOSE: To prevent defective washing when the composition, the temperature, the flow rate and the washing time of a washing liquid is set in advance to wash a material to be washed by preparing change pattern with time in which various conditions in a case when washing had suitably been performed in advance are fetched and performing washing while comparing the actually measured value with the change pattern. CONSTITUTION: Washing work of a pipe line 53 partitioned by valves 42, 45, 46, 47, 48 is carried out in compliance with work procedures prepared based on the results of a washing test made in advance. That is, first, a washing liquid is prepared in a washing liquid preparing tank 1 based on the work procedures and is heated to a prescribed temp. Next, the washing liquid is forcibly fed by a pump 5 with the opening degree of a valve 19 being controlled so that the flow rate in the pipe line 53 becomes a prescribed value. During washing,by a flow meter 9, a temperature gage 10, a pH meter 11, conductometric devices 12, 13, flow meters 21, 22 and temperature gages 24, 26, information on washing is collected with time to monitor the washing conditions. From a point of time when all the monitors satisfy the prescribed washing conditions, washing is continued for a set time.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cleaning method and a cleaning apparatus for cleaning an object to be cleaned, especially a facility for manufacturing medicines and foods.

[0002]

2. Description of the Related Art In manufacturing pharmaceutical products, it is strictly required to maintain their quality. For this reason, the manufacturing facility must be equipped with a tank,
Strict cleaning of valves and piping is required. Similarly, in the food manufacturing industry as well, in order to prevent the occurrence of food poisoning and the like, sufficient washing operation is required in order to maintain good hygiene of the manufacturing equipment. In recent years, due to the increase in the size of manufacturing equipment and the development of computer control technology, a stationary cleaning method has been adopted in which cleaning is performed by passing a cleaning liquid inside without replacing the equipment by disassembling and cleaning it by hand. Came to be. This method involves contacting hot water, an acidic solution, an alkaline solution, and a surfactant solution for cleaning as a cleaning liquid on the surface of the tank, pipes, valves, etc. constituting the pharmaceutical or food manufacturing facility to be cleaned. It removes the dirt adhering to the.

Regarding this cleaning method in place, Firm Tech Japan Vol.8, No.8, pp.31-38 (Pharm
Tech Japan, Vol.8, No.8, P32-38,199
The outline is described in 2).

Another related publication is Japanese Patent Laid-Open No. 62-
No. 106882, No. 62-106883, and Japanese Patent Laid-Open No. 2-15707.
There are publications such as No. 7.

[0005]

The problem in the stationary cleaning method is to establish a cleaning method that does not cause stains to remain. The usual cleaning method is to perform a preliminary cleaning test in advance to confirm the cleaning conditions that completely remove the dirt, and then program and maintain this cleaning condition in the cleaning work procedure manual. Cleaning is carried out along the line.

In the conventional cleaning methods, in order to monitor the cleaning under the set cleaning conditions, the flow rate, the temperature, and the pressure of the cleaning liquid are measured at the inlet of the device to be cleaned, and the end where the cleaning liquid flows out. A means for measuring electric conductivity was installed in the part.

However, in such a monitoring method, when an abnormality occurs in the equipment constituting the cleaning apparatus or the plant to be cleaned, it is difficult to detect it properly, and the quality of the product is deteriorated due to poor cleaning. May invite you.

The present inventors diligently studied a cleaning method and a cleaning apparatus that completely fulfill the cleaning conditions set in advance in the cleaning work procedure manual so as not to cause residual stains and confirm the cleaning conditions. As a result, a means for detecting the cleaning state is installed in the portion to be cleaned, and the flow rate, pressure, temperature, and electric conductivity when the cleaning is properly performed beforehand based on the information on the portion to be cleaned obtained from the measuring means. , It is possible to achieve the above object by preparing a change pattern over time that incorporates at least one of absorbance and pH, and comparing it with the measured value to judge whether cleaning is being performed properly or not. I found it.

An object of the present invention is to provide a cleaning method and a cleaning device for removing stains adhering to the inside of a pharmaceutical or food manufacturing facility, and a cleaning method and a cleaning device for surely performing the cleaning specified in the cleaning procedure manual. To provide.

[0010]

A cleaning method according to the present invention is a method for cleaning an object to be cleaned by presetting the composition, temperature, flow rate, and cleaning time of a cleaning liquid, when cleaning is performed properly beforehand. Prepare a change pattern over time that incorporates one or more of flow rate, pressure, temperature, electrical conductivity, absorbance, and pH, and compare it with the measured value to determine whether cleaning is being performed properly It is characterized by doing.

The article to be cleaned is an article composed of a piping valve, a tank and the like.

The above-mentioned change pattern is prepared based on the information from the measuring device for taking in one or more of the flow rate, pressure, temperature, electric conductivity, absorbance, and pH set on the object to be cleaned. , And determine whether or not the cleaning is properly performed by comparing with the actual measurement value measured by the same measuring device.

The cleaning apparatus according to the present invention is a cleaning apparatus for cleaning an object to be cleaned by presetting the composition, temperature, flow rate and cleaning time of the cleaning solution.
At least 1 of pressure, pH, electric conductivity, and UV absorbance
A computer that includes means for measuring more than one type and that includes a computer that captures the measurement data obtained from each of the measurement means as electrical information and a storage means that stores each of the measurement data organized by the computer, and obtains from the measurement means. Flow rate, pressure, temperature, electrical conductivity, absorbance, etc. when properly cleaned in advance based on the information on the part to be cleaned.
The method is characterized in that a change pattern over time, in which one or more pH values are taken in, is prepared, and compared with an actual measurement value to judge whether or not the cleaning is properly performed.

The above cleaning apparatus compares a change pattern over time when the cleaning is properly performed in advance with an actual measurement value, and when a difference larger than a preset allowable range is detected, The computer output device is used to teach the operators that there is a risk of abnormalities and the devices and parts that require inspection.

The pharmaceutical manufacturing apparatus according to the present invention is equipped with a cleaning device for cleaning by presetting the composition, temperature, flow rate and cleaning time of the cleaning liquid, and the pipes, valves and tanks of the manufacturing device are provided at important points. A computer is provided with means for measuring at least one of the flow rate, temperature, pressure, pH, electric conductivity, and ultraviolet absorbance of the cleaning liquid, and the computer that takes in the measurement data obtained from each of the measuring means as electrical information is organized by the computer. And a storage means for storing each of the measurement data, and based on the information on the portion to be cleaned obtained from the measurement means, the flow rate, the pressure, the temperature, the electric conductivity, the absorbance, when the cleaning is properly performed in advance. Specially, prepare a change pattern over time that incorporates one or more pH values and compare it with the measured value to determine whether or not the cleaning is being performed properly. To.

When the above-mentioned cleaning of the pharmaceutical manufacturing apparatus is divided into a plurality of cleaning paths for cleaning, at least one kind of measuring means is provided in each of the divided cleaning paths.

The above-mentioned pharmaceutical manufacturing apparatus compares the measurement information of each measuring means with the measurement information of the past cleaning stored in the storage means, and a difference larger than a preset allowable range is detected. In this case, the operator is instructed by a computer output device that there is a possibility that an abnormality will occur and that the equipment and parts that need to be inspected.

[0018]

[Operation] When operating the manufacturing equipment, a cleaning test is carried out, and a change pattern due to the passage of time when one or more of flow rate, pressure, temperature, electric conductivity, absorbance, and pH is taken in when properly cleaned is taken. prepare. The cleaning test is performed at least twice, and the error range (allowable range) of the change pattern is obtained. These change patterns and error ranges are loaded into a computer as electrical information, arranged and stored in an information storage device to construct a database.

In the cleaning operation carried out after the operation of the manufacturing apparatus, the cleaning is carried out while comparing the above-mentioned change pattern with the measured value to judge whether or not the cleaning is properly performed.

The above-mentioned manufacturing apparatus is composed of pipes, valves, tanks, etc., and a detection means for confirming the cleaning condition is installed at each part thereof.

As the means for detecting the cleaning state, at least one kind of measuring device for detecting the flow velocity, pressure, temperature, electric conductivity, and ultraviolet absorbance of the cleaning liquid is used. The flow velocity measuring device provides flow velocity information of the cleaning liquid flowing in the pipe, and the pressure measuring device provides pressure information on the cleaning liquid. The temperature and conductivity measuring devices provide information on the temperature and conductivity of the cleaning liquid, respectively.

It is desirable that these measuring devices are installed in a portion to be cleaned. In the case of pipes, especially in the case of complex plants, it is not possible to clean the inside of all the pipes by a single cleaning operation, and it is necessary to switch the flow path of the cleaning liquid and clean it several times. In such cases, it is desirable to install a measuring device for each flow path. That is, when the cleaning liquid flows in parallel to the originally closed flow path due to the failure of the flow path switching valve, the cleaning liquid is cleaned at a flow rate lower than a predetermined flow rate, which may cause cleaning failure. The conventional method of monitoring the entrance and exit may not be able to detect such an abnormality. On the other hand, the method of the present invention in which the measuring device is installed in each flow path can reliably detect the abnormality.

When the object to be cleaned is a tank and a cleaning liquid is sprayed on the inner wall surface for cleaning, any one of the measuring devices for detecting pressure, temperature and electric conductivity on the surface to be cleaned is used.
Install more than one type. These measuring devices provide useful information about the pressure and temperature of the cleaning liquid sprayed on the surface to be cleaned and the concentration of the cleaning agent.

The measurement information obtained from the above measuring device is
The data is taken in a computer as electrical information, organized, and then stored in an information storage device to build a database.

The computer compares the measurement information of each measuring means with the previously prepared change pattern and the measurement information at the time of the past cleaning stored in the storage means, and sets a preset allowable range. If a larger difference is detected, the operator is informed of the possibility that an abnormality will occur and the equipment and parts that require inspection by means of a computer output device.

In addition to the above-mentioned measurement data, it is preferable that the information such as the open / closed state of each valve in the piping path, the operating state of the pump, etc. be fetched into the computer, organized and stored in order to verify the cleaning process. Also, each measurement data is arranged in time series, and this is printed and saved as a cleaning record. This cleaning record and database will be
When verifying product quality, this information is indispensable for verifying that a series of cleaning operations have been successfully performed.

[0027]

Embodiments will be described in detail below based on embodiments according to the present invention.

Example 1 FIG. 1 shows a cleaning method according to the present invention. The parts to be cleaned in this embodiment are valves 42, 45, 46, 47 and 4.
It is a pipeline 53 divided by 8. The cleaning work of the pipe line 53 is performed in compliance with the work procedure manual prepared based on the result of the cleaning test performed in advance. If the cleaning work is performed in compliance with this work procedure manual, the contents will not cause cleaning failure. In this work procedure manual, the water to be used is deionized water, sodium hydroxide is used as a cleaning agent, the concentration of sodium hydroxide is 5%, and the cleaning liquid temperature is 80 ° C or higher. That is, the flow rate of the cleaning liquid in the conduit 53 is 2.0 m / sec or more, the cleaning is performed for 5 minutes or more, and the cleaning order is specified.

First, a cleaning liquid was prepared in the cleaning liquid preparation tank 1 based on the work procedure manual, and the temperature was raised to 80 ° C. or higher. Then, the opening of the valve 19 was adjusted by the pump 5 so that the flow velocity in the conduit 53, which is the object to be cleaned, was 2 m / sec, and the cleaning liquid was pressure-fed.

A flow rate measuring device 9, a temperature measuring device 10, and a pH measuring device 1 are provided in the washing liquid circulation pipe line connected to the pipe line 53.
1, electrical conductivity measuring devices 12 and 13 are installed. The conduit 53 is divided by the valve 44 into conduits 53a and 53b. The flow rate measuring device 2 is provided in the pipelines 53a and 53b.
1, 22 and temperature measuring devices 24, 26 are provided.

In this embodiment, since the conduit 53 is divided into two in the middle, the conduit 53 is divided into the conduits 53a and 53b for cleaning. That is, first, the valves 44 and 47 were closed, the valves 43 and 46 were opened, and the cleaning liquid was passed through. During the cleaning, the flow rate measuring device 9, the temperature measuring device 10, the pH measuring device 11, the electric conductivity measuring devices 12, 13 of the cleaning liquid circulation pipe, and the flow measuring device 22 and the temperature measuring device 26 provided in the conduit 53b.
The cleaning status was monitored by. From the time when all the monitoring devices reach the predetermined washing conditions, that is, when the temperature reaches 80 ° C. or more, the washing liquid flow rate is 2 m / sec, the pH and the electric conductivity reach the numerical values of the 5% sodium hydroxide solution, the set time ( Washing was continued for 5 minutes.

The conduit 53a was washed subsequently to the conduit 53b. That is, valves 43 and 46 are closed and valve 44 is
And 47 were opened to pass the washing solution. Pipe line 5 during cleaning
As in the case of 3b, the flow rate measuring device 9, the temperature measuring device 10, the pH measuring device 11, the electrical conductivity measuring devices 12, 13 of the cleaning liquid circulation pipe, the flow measuring device 21 provided in the pipe 53a, and the temperature measurement. The device 24 monitors the cleaning status. From the time when it was confirmed by these monitoring devices that the temperature reached 80 ° C or higher, the washing liquid flow rate was 2 m / sec, the pH and the electric conductivity reached the numerical values of the 5% sodium hydroxide solution,
The cleaning was scheduled to continue for the set time (5 minutes).

FIG. 2 shows the change patterns of the temperature and the flow velocity measured by each measuring device in this embodiment. The range shown by the dotted line in FIG. 2 shows the allowable range determined based on the result of the cleaning test in which cleaning was properly performed. From this result, in the cleaning of the conduit 53a, the temperature rise pattern,
It was found that the flow velocity pattern was out of the allowable range. In addition, the flow of the cleaning liquid was measured by the flow rate measuring device 22 which should not flow. From this, the pipeline 53a
It is possible to easily determine that an abnormal situation in which the valves 43 and 46 cannot be closed due to a malfunction is occurring in the cleaning. As a result, the occurrence of defective cleaning can be prevented in advance, so that the reliability of the cleaning operation, and thus the reliability of the quality of the final product, can be improved.

As the measuring device installed in the portion to be cleaned, it is preferable to use a non-contact measuring method from outside the conduit.

In this embodiment, the flow rate of the cleaning liquid in the cleaning portion,
Information on temperature can be obtained. Therefore, since the cleaning information of the cleaning portion can be directly measured, it is possible to easily and surely verify that the cleaning is performed under the preset conditions, as compared with the conventional method described in Comparative Example 1.

Comparative Example 1 FIG. 3 shows a conventional cleaning method except that the flow rate measuring devices 21 and 22 and the temperature measuring devices 24 and 26 of the pipe lines 53a and 53b in the first embodiment are removed. In the conventional cleaning procedure manual, as in the case of Example 1, the water used is deionized water, sodium hydroxide is used as a cleaning agent, and the concentration of sodium hydroxide is 5%. That the temperature of the cleaning liquid is 80 ° C or higher, and the conduit 53
The cleaning liquid flow rate in the above is 2.0 m / sec or more, the cleaning is performed for 5 minutes or more, and the cleaning order is specified. However, since a detection device such as a flow rate measuring device or a temperature measuring device for monitoring the cleaning condition is not installed in the portion to be cleaned, the flow rate measuring device 9, the temperature measuring device 10, the pH measuring device provided in the cleaning liquid circulation pipe line are installed. It is only possible to infer that the cleaning is being carried out based on the measurement information obtained from the device 11 and the electric conductivity measuring device 12 on the cleaning liquid supply side and the outlet side.

Therefore, even if the cleaning is performed based on the work procedure manual, the cleaning liquid is prepared in the cleaning liquid preparation tank 1 and the temperature is raised to 80 ° C. or higher, and the flow velocity in the pipe 53 which is the object to be cleaned by the pump 5. The cleaning liquid was pressure-fed by adjusting the opening degree of the valve 19 so as to be 2 m / sec., Each detection device had a temperature of 80 degrees or more, a cleaning liquid flow rate of 2 m / sec, pH and electric conductivity of 5%.
It was only confirmed that the cleaning was continued for the set time (5 minutes) from the time when the value corresponding to the sodium hydroxide solution was reached. That is, it cannot be confirmed that the portion to be cleaned has been cleaned under the conditions described in the work procedure manual.

Further, in this comparative example, the conduit 53b
When the pipe line 53a is cleaned subsequently to the cleaning process 1), it cannot be detected even if the valves 43 and 46 are accidentally left open. Therefore, the flow rate of the cleaning liquid in the pipe becomes equal to or lower than a predetermined flow rate, which may lead to poor cleaning of the mounting portion of the valve 48 and contaminants accumulated in the mounting portion of the valve 48 may be mixed into the product.

Example 2 FIG. 4 is a diagram showing the cleaning solution circulation line and the line 5 in Example 1.
Electrical conductivity measuring devices 13, 23, 28 on 3a and 53b
In addition, the purified water producing device 7 for rinse, the three-way valves 40, 49 for switching the cleaning liquid circulation pipe passage, each measuring device,
Computer 6 that takes in information from the device and controls it
0 and a database 61.

After the cleaning using the cleaning agent is completed by the method described in Example 1, the three-way valves 40 and 49 are switched, and purified water is supplied from the purified water producing apparatus 7 to rinse the pipe 53. did. This step is carried out in order to prevent the alkali, acid, and cleaning surfactant used for cleaning from remaining in the pipeline and mixing in the product. Therefore, as the rinse water, water equivalent to the highly purified water used for manufacturing the product is used, and the electric conductivity is low. An electric conductivity measuring device is installed in the purified water manufacturing device 7 to constantly manufacture purified water of a constant quality.
This is monitored and recorded.

The rinse water supplied to the conduit 53 dissolves and pushes out dirt and cleaning liquid accumulated in the conduit to clean the inside. In the rinsing step, it is monitored by the electric conductivity measuring device 12 of the cleaning liquid circulation pipe connected to the object to be cleaned that the rinsing drainage has decreased to an electric conductivity equivalent to that of purified water. If the purified purified water for rinse and the rinse wastewater have the same water quality, it can be determined that there is no dissolution of the substance that deteriorates the water quality in the rinse system, that is, the rinse is completed.

The computer 60 calculates and obtains a control index from the electrical information, controls the amount of purified rinse water supplied so as to match the cleaning conditions described in the cleaning procedure manual,
Rinsing is performed by opening and closing valves at various places.

The computer 60 is provided with a cleaning liquid circulation pipe,
Information relating to the cleaning of the pipe 53, various measuring devices installed at various points of the purified water producing device 7, valves, etc. is fetched as electrical information over time and stored in the database 61.

FIG. 5 shows the time course of the electric conductivity measured by the electric conductivity measuring devices 12 and 23 in the rinse of the conduit 53a. In the figure, A indicates the electric conductivity measuring device 23, B indicates the electric conductivity measuring device 12, the C ₀ indicates the electric conductivity of the cleaning liquid, and the Ce indicates the target electric conductivity. From the above measurement results, the computer 60
Times t ₁ and t ₂ when the cleaning liquid is diluted with the rinse liquid and a decrease in electric conductivity is recognized, and times t ₃ and t ₄ when the target electric conductivity Ce is reached, and a change rate Ka of the electric conductivity,
Calculate Kb. The computer 60 stores these results in the database 61.

Further, the computer 60 performs comparison with the past rinse results stored in the database 61,
It is determined whether or not it is within a preset allowable range.
FIG. 6 shows the value of the electric conductivity change rate Kb based on the measurement result of the electric conductivity measuring device 12 in the rinse of the pipe line 53a, calculated for each number of times of cleaning performed so far. In FIG. 6, Kb fell below the lower limit at the 9th time. Since the rinsing work is controlled so as to meet the conditions described in the cleaning work procedure manual, the rinsing work usually has almost the same level. Therefore, if the value of the electric conductivity change rate Kb is out of the allowable range, it means that the computer 60 cannot control the value. The allowable range of the electrical conductivity change rate K is set based on the cleaning results. If the value of the electrical conductivity change rate K in the rinsing work is out of the allowable range, the operator is informed that an abnormality may occur in the computer output device. That is, a warning is given by light, video, sound, etc. that there is a possibility that an abnormality has occurred in the measuring device used for control by the computer 60, the detection device for monitoring the cleaning condition, the cleaning flow path switching valve, and the like. At this time, adding a function to display a measuring device or a plant device in which an abnormality may occur is very useful for efficient inspection work. When the apparatus was inspected after the ninth cleaning shown in FIG. 6, it was found that a part of the rinse liquid leaked from the valve 48 to the outside of the cleaning flow path due to the damage of the diaphragm of the valve 48.

If the above result is within the preset allowable range, it is determined whether or not a particular tendency is detected in comparison with the past rinse results. That is, it is determined whether the values of t ₁ , t ₂ , t ₃ , t ₄ and Ka, Kb are gradually increased or decreased. In particular, when t _{1 to} t ₄ increases and Ka and Kb continuously decrease, it is possible that dirt is gradually accumulating in the system to be cleaned and there is an abnormality in the plant equipment. It will be an index to show that. In this way, when a specific tendency is detected in comparison with the past cleaning results, the operator is instructed that there is a possibility that an abnormality will occur in the computer output device. That is, there is a possibility that dirt remains on the portion to be cleaned, and there is an abnormality in the measuring device used by the computer 60 for control, the detection device for monitoring the cleaning condition, the cleaning flow path switching valve, and the like. There is a warning by light, video, audio, etc. At this time, adding a function to display the portion to be cleaned, the measuring device, and the plant equipment in which an abnormality may occur is very useful for efficient inspection work. 1 in FIG.
Since the Kb continuously decreased from the 8th time to the 22nd time, the pipe 53a was disassembled and the presence or absence of stains was inspected. As a result, some stains were found at the branch portion to the valve 48. . For this reason, we have made improvements such as increasing the flow rate of the cleaning solution to 2.5 m / sec among the cleaning conditions specified in the cleaning procedure manual.

According to the present embodiment, since the means for directly measuring the rinse condition is provided, it is possible not only to directly confirm that the rinse has been performed under the predetermined rinse condition, but also to save the past stored in the database. By comparing with the cleaning data, the presence of dirt that is gradually accumulating in the object to be cleaned and the occurrence of abnormalities in plant equipment are detected, and the operator is alerted to this to prevent the occurrence of poor cleaning. Can contribute to quality control of the final product.

Embodiment 3 FIG. 7 shows an outline of an embodiment of a pharmaceutical manufacturing apparatus using the cleaning method according to the present invention. The objects to be cleaned in this embodiment are the tanks 50 and 51 defined by the valves 35, 36, 37, 38, and 39, and the pipeline 52. The cleaning apparatus according to this embodiment includes a cleaning liquid preparation tank 1, an acidic cleaning liquid storage tank 2, an alkaline cleaning liquid storage tank 3, a heat exchanger 4, a pump 5,
6, purified water manufacturing device 7, flow rate measuring device 8, 9, 21, 2
2, temperature measuring device 10, 24, 26, pH measuring device 1
1, electric conductivity measuring device 12, 13, pressure measuring device 2
5, 27, each measuring device, a computer 60 for fetching and controlling information from the device, a database 61, and piping, valves and an information transmission circuit for connecting these. Note that FIG. 7 shows the outline of the present embodiment, and the description of various gases and vapors not related to cleaning, various measuring devices, auxiliary devices such as stirring devices, etc. is omitted.

The cleaning operation in this embodiment is carried out by three steps of a preliminary cleaning step, a main cleaning step and a rinsing step. These washing operations are performed in compliance with the work procedure manual prepared based on the results of the washing test performed in advance. If the cleaning work is performed in compliance with this work procedure manual, the contents will not cause cleaning failure. In this work procedure manual, the type of cleaning water to be used, the cleaning chemical and its concentration, the cleaning liquid temperature, the cleaning liquid supply rate, the cleaning time, and the cleaning sequence are specified for each process. The contents of the work procedure manual are
It is transplanted to the computer 60 that controls the washing operation. In order to prevent the work procedure manual ported to the computer 60 from being rewritten without permission, security measures are taken so that only the authorized person can change the contents.

First, when starting the cleaning, the names of the supervisor who instructed the work, the person in charge of the cleaning work, and the worker in charge of the cleaning are registered in the computer 60, and it is confirmed that the manager or the worker is authorized. Confirm. When registering a name, security measures have been taken to confirm the identity of the individual.

Preliminary washing step: First, purified water is supplied from the purified water manufacturing apparatus 7 to the drug manufacturing apparatus to be cleaned. That is, the three-way valves 31, 35, 36, 37, 38,
39, 40 are operated to operate the tanks 50, 51 and the pipeline 52.
To remove dirt that is relatively easy to remove. As for the amount of purified water supplied, spray balls 14 to 16 are used for the tank.
Was adjusted so as to be sprayed at an average rate of 30 liters / min per 1 m of perimeter and the cleaning liquid was adjusted to flow at a speed of 2 m / sec in the pipe. Since the supply capacity of the purified water producing apparatus 7 used in this example is small, preliminary cleaning was performed separately for the tanks 50, 51 and the pipe line 52. Regarding the conduit 52, the valve 41 and the three-way valve 38 were operated from the structure of the conduit to be divided into 52a and 52b for cleaning.

The purified water comes into contact with the dirt component while passing through the inside of the object to be washed, and is separated from the wall surface or dissolved to remove it.

If warm purified water is used for the preliminary washing, the efficiency of removing dirt is increased. In this case, after the purified water is stored in the cleaning liquid preparation tank 1, the pump 5 sends the liquid through the heat exchanger 4. Steam is supplied to the heat exchanger, and the purified water is heated to the temperature described in the work procedure manual. The temperature of the purified water is adjusted by adjusting the steam supply amount based on the data of the temperature measuring device 10. The amount of purified water supplied is controlled by valve 19.
It was adjusted by opening and closing. The tank 50 to be cleaned,
51 and the pipe 52 are provided with flow rate measuring devices 21, 22, temperature measuring devices 24, 26, pressure measuring devices 25, 27, and an electric conductivity measuring device 12 is installed in the cleaning liquid flow path. Obtain information on the flow rate, temperature, pressure, and electrical conductivity of the cleaning liquid during cleaning. Computer 60
Creates a change pattern over time based on these measurement information, compares it with a change pattern prepared in advance when properly cleaned, and the preliminary cleaning complies with the work procedure manual. Determine what has been done.

Furthermore, since the cleaning information of the cleaning portion can be directly measured, it is possible to easily and surely verify that the preliminary cleaning has been performed under the set conditions, as compared with the conventional case.

It is important that the purified water used for the preliminary washing does not contain organic substances, inorganic salts and particles in the water. Usually, it is desirable to use purified water prepared by combining purification steps such as distillation, membrane filtration and ion exchange. If the object of cleaning requires high quality control, purified water with a higher degree of purification is used.

The preliminary cleaning liquid discharged from the cleaning tank 50 is transferred to the cleaning wastewater treatment device 17 by the pump 6. If the amount of dirt components in the wash water is very small before the completion of the preliminary wash, the three-way valve 40 is operated to store the wash water in the wash liquid preparation tank 1 and use it as the main wash water described later to save the wash water. Also, the amount of cleaning wastewater generated can be reduced.

Main cleaning step: When the preliminary cleaning step is completed, a main cleaning step using an acid or alkaline cleaning agent is carried out. First, depending on the main component of the dirt attached to the object to be cleaned, it is selected whether to use an acidic cleaner or an alkaline cleaner as the cleaner. In the cleaning liquid preparation tank 1, the three-way valve 31 is operated from the purified water manufacturing device 7 and the purified water is put therein. In addition, the three-way valves 35, 36, 37 are operated to shut off the purified water piping, and the cleaning liquid from the cleaning liquid preparation tank 1 is supplied to the tanks 50, 51 and the conduit 52 to be cleaned. To change. The purified water in the cleaning liquid preparation tank 1 is added with an acidic cleaning agent or an alkaline cleaning agent while being pumped to an object to be cleaned by a pump 5, and is heated by a heat exchanger 4 to a temperature described in a work procedure manual. To be done.
The concentration of the cleaning agent in the cleaning solution is based on the measured values of the pH measuring device 11 and the electric conductivity measuring device 13, and when the acidic cleaning agent is used, the valve 33 is adjusted from the acidic cleaning solution storage tank 2 to adjust the alkaline cleaning agent. In the case of using the above, by adjusting the valve 34 from the alkaline cleaning liquid storage tank 3, it is supplied so as to have a concentration specified in the work procedure manual. Based on the information from the flow rate measuring device 9, the flow rate of the cleaning liquid is adjusted by opening and closing the valve 19 so that the flow rate is determined by the cleaning section in the cleaning procedure manual. The temperature of the cleaning liquid is adjusted by adjusting the amount of steam supplied to the heat exchanger 4 based on the data of the temperature measuring device 10.

The supply of the acid or alkaline cleaning agent and the heating of the cleaning liquid may be performed in the cleaning liquid preparation tank 1.
The cleaning liquid is returned to the cleaning liquid preparation tank 1 by the pump 6 and reused. It should be noted that instead of repeatedly using the cleaning liquid as in the present embodiment, it may be disposable depending on the object of cleaning and the type and amount of dirt. The used cleaning liquid is detoxified by the cleaning wastewater treatment device 17 and then discharged.

Flow rate measuring devices 21, 22 and temperature measuring device 2 are installed in the tanks 50, 51 and the conduit 52 to be cleaned.
4, 26, pressure measuring devices 25 and 27, and a flow rate measuring device 9, a temperature measuring device 10, a pressure measuring device 11, and an electric conductivity measuring device 12 are installed in the cleaning liquid flow path, which are used for cleaning work. The flow rate, temperature, pressure, and electrical conductivity information of the cleaning liquid in each part can be directly monitored. The computer 60, based on these measurement information,
A change pattern over time is created and compared with a change pattern prepared in advance when properly cleaned, and it is determined that the main cleaning is performed in compliance with the work procedure manual.

Further, since the cleaning information of the cleaning portion can be directly measured, it is possible to easily and surely verify that the cleaning has been performed under the set conditions, as compared with the conventional case. Rinse step: After the main cleaning step is completed, a rinse with purified water is carried out to prevent an acid or alkaline cleaning agent from remaining on the object to be cleaned. First, the three-way valves 31, 35, 36,
By operating 37 and 40, the flow path is changed so that the purified water is supplied from the purified water producing apparatus 7 to the tanks 50, 51 and the pipeline 52 to be cleaned. Then, the rinse with the purified water is continued until the acid or alkaline cleaning agent remains in the tank 50 to be cleaned. In the rinsing step, it is necessary to continuously measure the electric conductivity of the rinse liquid with the electric conductivity measuring device 12.
If the electric conductivity of the rinse liquid measured by the electric conductivity measuring device 12 is high as compared with the electric conductivity of the purified water supplied from the purified water producing device 7, an acid or alkaline cleaning agent is present in the object to be cleaned. It can be judged that it remains.

Purification in the cleaning portion in the rinse step by the flow rate measuring devices 21, 22, temperature measuring devices 24, 26 and pressure measuring devices 25, 27 installed in the tanks 50, 51 to be cleaned and the pipe line 52. Directly measure water flow rate, temperature, pressure, and electrical conductivity. The computer 60 creates a change pattern over time based on these measurement information, compares it with a change pattern prepared in advance when properly rinsed, and the rinse complies with the work procedure manual. It is determined that it was done. further,
In this example, since it is possible to obtain information obtained by directly measuring the flow rate, temperature, pressure, and electric conductivity of the purified water in the washing part, the rinse can be performed more easily than the conventional pharmaceutical manufacturing apparatus equipped with the washing apparatus. It is possible to easily and surely verify that the operation has been performed under the set conditions.

The computer 60 controls various measuring devices and equipment installed in the plant so as to comply with the cleaning conditions and cleaning methods defined in the cleaning procedure manual for each of the above cleaning steps. Further, the purified water producing device 7, the washing device, and the flow rate measuring devices 8, 9, 21, 22, 22 installed at respective points of the washing target, temperature measuring devices 10, 24, 26,
Information relating to cleaning such as the pressure measuring devices 25 and 27, the pH measuring device 11, the electric conductivity measuring device 12, and the opening / closing states of the valves 31 to 41 is fetched as electric information with time.
This is stored in the database 61. Database 61
In order to prevent the contents stored in it from being rewritten without permission, security measures are in place that cannot be changed except by the authorized person.

The computer arranges these pieces of information over time to create a cleaning record. The cleaning record includes the name of the person in charge of cleaning work, the name of the worker, the time to start the work, the start time of each unit process in the cleaning work, the time to reach the cleaning conditions defined in the cleaning procedure and the process end time, The progress of the cleaning work such as the cleaning conditions, the information of the measuring device and the valve opening / closing status will be recorded in detail.

If any abnormality is found during the cleaning operation, the computer records the phenomenon in the cleaning record. The operator inputs the judgment of the abnormal phenomenon and how it was dealt with in the computer, and records it in the cleaning record.
In such a case, the reason for the judgment, the name of the person in charge of judgment, and the confirmation by the operator are described, and the confirmation of the supervisor is obtained.

The information stored in the database can be retrieved at a later date as needed and used for analysis of the cleaning content.

The cleaning record and database information stored as documents are useful information for verifying that a series of cleaning operations have been performed without any abnormalities. further,
It is extremely useful for verifying whether or not there is any problem in the cleaning work in investigating the cause when an abnormality occurs in the product quality.

According to the present embodiment, it is possible to provide a cleaning device which can be cleaned while confirming that it is operating under preset conditions. In addition, the automatically created cleaning records and database facilitate verification of cleaning operations.

[0068]

EFFECT OF THE INVENTION By providing a cleaning device capable of cleaning while confirming that it is operating under preset conditions, it is possible to prevent cleaning defects from occurring.

Further, since the cleaning record is automatically created and the cleaning data stored in the database can be analyzed by the computer, it becomes easy to verify that the cleaning operation is performed without any abnormality.

[Brief description of drawings]

FIG. 1 shows a cleaning method according to the present invention.

FIG. 2 shows a change pattern of temperature and cleaning liquid flow rate with time in the cleaning method according to the present invention.

FIG. 3 shows a conventional cleaning method.

FIG. 4 shows an outline of an embodiment based on the cleaning method and the cleaning apparatus according to the present invention.

FIG. 5 shows an example of a cleaning method according to the present invention.

FIG. 6 shows a trend of a change rate of electric conductivity in the cleaning method according to the present invention.

FIG. 7 shows an outline of an embodiment based on the cleaning method and the cleaning apparatus according to the present invention.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Cleaning liquid preparation tank, 2 ... Acidic cleaning liquid storage tank, 3 ... Alkaline cleaning liquid storage tank, 4 ... Heat exchanger, 5, 6 ... Pump, 7 ... Purified water manufacturing apparatus, 8, 9, 21, 22 ... Flow rate measuring apparatus, 1
0, 24, 26 ... Temperature measuring device, 11 ... pH measuring device,
12, 13, 23, 28 ... Electrical conductivity measuring device, 25, 2
7 ... Pressure measuring device, 19, 31-49 ... Valve, 50, 51
... tanks, 52, 53 ... pipelines, 60 ... computers.

Claims (6)

[Claims] 1. A method for cleaning an object to be cleaned by presetting the composition, temperature, flow rate and cleaning time of a cleaning liquid, wherein the flow rate, pressure, temperature, electric conductivity and absorbance when properly cleaned in advance. A cleaning method comprising preparing a change pattern of one or more pH values over time, and comparing the measured value with a measured value to determine whether or not the cleaning is properly performed. 2. The cleaning method according to claim 1, wherein the object to be cleaned is an article including at least one of a pipe, a valve and a tank. 3. An object to be cleaned is provided with a measuring device for taking in one or more of flow rate, pressure, temperature, electric conductivity, absorbance, and pH, and the flow rate, pressure when properly cleaned in advance,
Whether or not cleaning is performed properly by preparing a change pattern over time that incorporates one or more of temperature, electrical conductivity, absorbance, and pH, and comparing the measured value measured by the measuring device with the change pattern. 3. The cleaning method according to claim 1, wherein the cleaning method is determined. 4. A cleaning apparatus for cleaning an object to be cleaned by presetting the composition, temperature, flow rate and cleaning time of the cleaning liquid, wherein the flow rate, temperature, pressure, pH, electric conductivity of the cleaning solution during cleaning of the object to be cleaned. Degree, a means for measuring at least one of UV absorbance, and a flow rate of the cleaning liquid when properly cleaned in advance,
Means for determining whether or not cleaning is properly performed by preparing a change pattern of one or more of pressure, temperature, electric conductivity, absorbance, and pH taken over time, and comparing with a measured value by the measuring means. And a cleaning device. 5. A means for issuing an alarm when a difference, which is larger than a preset allowable range, is detected by comparing a change pattern over time when a proper cleaning is performed in advance with a measured value. The cleaning device according to claim 4, further comprising: 6. An object to be cleaned is divided into a plurality of cleaning paths, cleaned with a cleaning solution, and at least one of flow rate, temperature, pressure, pH, electric conductivity, and ultraviolet absorbance of the cleaning solution flowing through the cleaning path is measured. Then, the cleaning method is characterized in that the cleaning is performed while judging whether or not the cleaning is properly performed by comparing with a change pattern of the measurement data over time when the cleaning is properly performed in advance.