JPH08242867A - イコサペンタエン酸生合成酵素群をコードする遺伝子及びイコサペンタエン酸の製造法 - Google Patents
イコサペンタエン酸生合成酵素群をコードする遺伝子及びイコサペンタエン酸の製造法Info
- Publication number
- JPH08242867A JPH08242867A JP8003485A JP348596A JPH08242867A JP H08242867 A JPH08242867 A JP H08242867A JP 8003485 A JP8003485 A JP 8003485A JP 348596 A JP348596 A JP 348596A JP H08242867 A JPH08242867 A JP H08242867A
- Authority
- JP
- Japan
- Prior art keywords
- ala
- leu
- ser
- gly
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
(57)【要約】
【課題】 イコサペンタエン酸（ＥＰＡ）の生合成酵素
群をコードする遺伝子を微生物から取得し、遺伝子組み
換え法により、ＥＰＡの有利な製造法を提供する。 【解決手段】 イコサペンタエン酸（ＥＰＡ）生合成酵
素群をコードする遺伝子を取得し、これをベクターと連
結してプラスミドを作成して該プラスミドにて大腸菌を
形質転換し、この形質転換した大腸菌を培養してＥＰＡ
を産生する。 【効果】 ＥＰＡは、医薬、食品、飼料等として有用で
ある。
群をコードする遺伝子を微生物から取得し、遺伝子組み
換え法により、ＥＰＡの有利な製造法を提供する。 【解決手段】 イコサペンタエン酸（ＥＰＡ）生合成酵
素群をコードする遺伝子を取得し、これをベクターと連
結してプラスミドを作成して該プラスミドにて大腸菌を
形質転換し、この形質転換した大腸菌を培養してＥＰＡ
を産生する。 【効果】 ＥＰＡは、医薬、食品、飼料等として有用で
ある。
Description
【０００１】
【発明の属する技術分野】この発明は、イコサペンタエ
ン酸（以下ＥＰＡと称する）生合成酵素群遺伝子、酵素
遺伝子を含有するプラスミド、該プラスミドにて形質転
換された生物、及び該生物を用いるＥＰＡの製造法に関
する。ＥＰＡは、医薬、食品、飼料などの原料として有
用である。
ン酸（以下ＥＰＡと称する）生合成酵素群遺伝子、酵素
遺伝子を含有するプラスミド、該プラスミドにて形質転
換された生物、及び該生物を用いるＥＰＡの製造法に関
する。ＥＰＡは、医薬、食品、飼料などの原料として有
用である。
【０００２】
【従来の技術】イコサペンタエン酸（ＥＰＡ）に代表さ
れる多価不飽和脂肪酸は、生体膜の構成成分として重要
な役割を担っている。またこれまでに知られているＥＰ
Ａの薬理作用として、以下のものがあげられる。 血小板凝集抑制作用（血栓溶解作用）血液中の中性
脂肪低下作用血液中のＶＬＤＬ−コレステロール、Ｌ
ＤＬ−コレステロール低下作用、ＨＤＬ−コレステロー
ル増加作用（抗動脈硬化作用）血液粘度低下作用血
圧降下作用抗炎症作用抗腫瘍作用。
れる多価不飽和脂肪酸は、生体膜の構成成分として重要
な役割を担っている。またこれまでに知られているＥＰ
Ａの薬理作用として、以下のものがあげられる。 血小板凝集抑制作用（血栓溶解作用）血液中の中性
脂肪低下作用血液中のＶＬＤＬ−コレステロール、Ｌ
ＤＬ−コレステロール低下作用、ＨＤＬ−コレステロー
ル増加作用（抗動脈硬化作用）血液粘度低下作用血
圧降下作用抗炎症作用抗腫瘍作用。
【０００３】さらに、プロスタグランジン類の生合成に
際し基質となり、ヒトを含む高等哺乳動物の体内で必須
の機能を発揮する。特にＥＰＡはタイプ３のプロスタグ
ランジン類の生成の際の基質として重要であって、血小
板の凝集抑制作用があり、血栓症の治療及び予防剤とし
ての応用が検討されている。さらにＥＰＡは、血漿コレ
ステロールレベルの低下に寄与する多価不飽和脂肪酸の
中でも特にその活性が高く、通常の植物油に含まれるリ
ノール酸などよりもはるかに有効である。また魚類等の
必須栄養素としても知られている。
際し基質となり、ヒトを含む高等哺乳動物の体内で必須
の機能を発揮する。特にＥＰＡはタイプ３のプロスタグ
ランジン類の生成の際の基質として重要であって、血小
板の凝集抑制作用があり、血栓症の治療及び予防剤とし
ての応用が検討されている。さらにＥＰＡは、血漿コレ
ステロールレベルの低下に寄与する多価不飽和脂肪酸の
中でも特にその活性が高く、通常の植物油に含まれるリ
ノール酸などよりもはるかに有効である。また魚類等の
必須栄養素としても知られている。
【０００４】このように、ＥＰＡの血栓防止作用あるい
は脂質低下作用に基づいて、健康食品あるいは医薬品と
しての可能性がデンマークのダイヤーベルグ(Am.J.Cli
n.Nutr.,28,958,1975)の疫学調査により明らかにされて
いるが、その化学構造から明らかなように、化学合成す
ることは極めて困難である。このようなことからわが国
においてもＥＰＡを多く含有するイワシ、サバ、サンマ
等の青背魚の摂食が推奨されるようになってきた。
は脂質低下作用に基づいて、健康食品あるいは医薬品と
しての可能性がデンマークのダイヤーベルグ(Am.J.Cli
n.Nutr.,28,958,1975)の疫学調査により明らかにされて
いるが、その化学構造から明らかなように、化学合成す
ることは極めて困難である。このようなことからわが国
においてもＥＰＡを多く含有するイワシ、サバ、サンマ
等の青背魚の摂食が推奨されるようになってきた。
【０００５】今日、健康食品として市販されているＥＰ
Ａは、そのほとんどが煮取法によって得られた魚油の分
別物であって、そのＥＰＡ含量は10〜30％程度である。
煮取法によって抽出される魚油は構成脂肪酸として多種
類の脂肪酸を含む混合グリセリドであって、各成分を単
離精製することが困難であるばかりでなく、ＥＰＡはす
べてシス型の二重結合を５個有する炭素数２０の直鎖の
多価不飽和脂肪酸である為に、極めて酸化され易い不安
定な脂肪酸であり、魚油からＥＰＡを濃縮する場合には
酸素・光・熱等を避けて行う必要がある。さらに、これ
ら魚油には、ＥＰＡ以外の多種類の脂肪酸が混入してい
るため、その分別が困難であり、またＥＰＡの分別に使
用される各種の有機溶剤は通常減圧下に除去されるが、
その完全除去は技術的及びコスト的に問題点が多い。
Ａは、そのほとんどが煮取法によって得られた魚油の分
別物であって、そのＥＰＡ含量は10〜30％程度である。
煮取法によって抽出される魚油は構成脂肪酸として多種
類の脂肪酸を含む混合グリセリドであって、各成分を単
離精製することが困難であるばかりでなく、ＥＰＡはす
べてシス型の二重結合を５個有する炭素数２０の直鎖の
多価不飽和脂肪酸である為に、極めて酸化され易い不安
定な脂肪酸であり、魚油からＥＰＡを濃縮する場合には
酸素・光・熱等を避けて行う必要がある。さらに、これ
ら魚油には、ＥＰＡ以外の多種類の脂肪酸が混入してい
るため、その分別が困難であり、またＥＰＡの分別に使
用される各種の有機溶剤は通常減圧下に除去されるが、
その完全除去は技術的及びコスト的に問題点が多い。
【０００６】医薬品としてのＥＰＡは、様々な方法によ
って抽出された魚油を酵素的にもしくはアルカリ条件下
で処理して遊離脂肪酸まで加水分解するかまたは該遊離
酸をメチルもしくはエチルエステルに変換した後、これ
らを低温分別結晶法、尿素付加法、減圧蒸留法または、
逆相クロマト法等により更に精製してＥＰＡ濃度を90％
以上としたものが多い。しかし、これらの方法を用いて
得られたＥＰＡ濃縮物は、工程中に多種類の有機溶剤が
使用されており、また200℃近くに加熱されたりするた
め、有機溶剤の残留やＥＰＡの重合、異性化あるいは酸
化等による変質の懸念をはらんでいる。更に、魚油等を
ＥＰＡの原料として用いた場合、心臓疾患の原因の一つ
として疑われているドコセン酸等の除去が困難であるた
め、健康食品、医薬品等に利用する上で問題点を残して
いる。
って抽出された魚油を酵素的にもしくはアルカリ条件下
で処理して遊離脂肪酸まで加水分解するかまたは該遊離
酸をメチルもしくはエチルエステルに変換した後、これ
らを低温分別結晶法、尿素付加法、減圧蒸留法または、
逆相クロマト法等により更に精製してＥＰＡ濃度を90％
以上としたものが多い。しかし、これらの方法を用いて
得られたＥＰＡ濃縮物は、工程中に多種類の有機溶剤が
使用されており、また200℃近くに加熱されたりするた
め、有機溶剤の残留やＥＰＡの重合、異性化あるいは酸
化等による変質の懸念をはらんでいる。更に、魚油等を
ＥＰＡの原料として用いた場合、心臓疾患の原因の一つ
として疑われているドコセン酸等の除去が困難であるた
め、健康食品、医薬品等に利用する上で問題点を残して
いる。
【０００７】一方、最近、不完全な精製・濃縮では、魚
臭が残るなどの欠点を有した魚油からの抽出法を改善す
ることを目的として、クロレラ、単細胞藻類モノダス、
ユーグレナあるいはけい藻等の微生物を用いたＥＰＡの
生産方法が検討されるようになり、微生物を利用したＥ
ＰＡ生産が注目されてきている。近年では、ゲラーマン
とシュレンク(J.L.Gellerman and H.Schlenk,BBA,573,2
3,1979)及び、山田等(昭和６１年度日本発酵工学大会、
1986)の発表で、ＥＰＡを産生するかび(糸状菌)につい
ての報告がなされた。
臭が残るなどの欠点を有した魚油からの抽出法を改善す
ることを目的として、クロレラ、単細胞藻類モノダス、
ユーグレナあるいはけい藻等の微生物を用いたＥＰＡの
生産方法が検討されるようになり、微生物を利用したＥ
ＰＡ生産が注目されてきている。近年では、ゲラーマン
とシュレンク(J.L.Gellerman and H.Schlenk,BBA,573,2
3,1979)及び、山田等(昭和６１年度日本発酵工学大会、
1986)の発表で、ＥＰＡを産生するかび(糸状菌)につい
ての報告がなされた。
【０００８】本発明者らは、培養時間が短く培養制御が
容易であり、遺伝子の取得も容易なバクテリアを利用し
たＥＰＡ含有脂質の発酵生産法を見出す目的で、ＥＰＡ
産生能を有するバクテリアを、広く海洋に求めて鋭意研
究した結果、シュードモナス(Pseudomonas)、アルテロ
モナス(Alteromonas)、シーワネラ(Shewanella)属に属
する新規のバクテリアがＥＰＡを生産することを見出し
た〔K.Yazawa et al.,J.Biochem.,103,5(1988); K.Yaza
wa et al.,Nippon Suisan Gakkaishi,54,1835(198
8)〕。
容易であり、遺伝子の取得も容易なバクテリアを利用し
たＥＰＡ含有脂質の発酵生産法を見出す目的で、ＥＰＡ
産生能を有するバクテリアを、広く海洋に求めて鋭意研
究した結果、シュードモナス(Pseudomonas)、アルテロ
モナス(Alteromonas)、シーワネラ(Shewanella)属に属
する新規のバクテリアがＥＰＡを生産することを見出し
た〔K.Yazawa et al.,J.Biochem.,103,5(1988); K.Yaza
wa et al.,Nippon Suisan Gakkaishi,54,1835(198
8)〕。
【０００９】ＥＰＡを含む多価不飽和脂肪酸の生合成系
は相当する飽和脂肪酸又はその前駆体となる飽和脂肪酸
の位置特異的な好気的不飽和化によることが示唆されて
いる〔例えば、R.Jeffcoat and A.T.James (1984) in :
S.Numa(Ed.): Fatty acid metabolism and its regula
tion, Elsevier, Amsterdam, pp 85-112〕。また、ＥＰ
Ａの合成に関与している生合成酵素群及びそれをコード
する遺伝子に関しては、特開平６−４６８６４号があ
る。
は相当する飽和脂肪酸又はその前駆体となる飽和脂肪酸
の位置特異的な好気的不飽和化によることが示唆されて
いる〔例えば、R.Jeffcoat and A.T.James (1984) in :
S.Numa(Ed.): Fatty acid metabolism and its regula
tion, Elsevier, Amsterdam, pp 85-112〕。また、ＥＰ
Ａの合成に関与している生合成酵素群及びそれをコード
する遺伝子に関しては、特開平６−４６８６４号があ
る。
【００１０】
【発明が解決しようとする課題】有用な物質を生産する
野生株の該有用物質の生産性は一般に低く、それらの微
生物の能力を工業的に利用しようとする場合、種々の方
法により微生物の改良、すなわち生産性の向上が行われ
る。本発明は、遺伝子組み換え法を用いて、文献未知の
ＥＰＡ生合成酵素群遺伝子を見出し、他の生物体に導入
することにより、ＥＰＡ生産性の向上を目指す研究や、
ＥＰＡ生合成能を持たない生物へのＥＰＡ生合成能の賦
与を目的としており、ひいてはＥＰＡの有利な製造法を
確立しようとするものである。
野生株の該有用物質の生産性は一般に低く、それらの微
生物の能力を工業的に利用しようとする場合、種々の方
法により微生物の改良、すなわち生産性の向上が行われ
る。本発明は、遺伝子組み換え法を用いて、文献未知の
ＥＰＡ生合成酵素群遺伝子を見出し、他の生物体に導入
することにより、ＥＰＡ生産性の向上を目指す研究や、
ＥＰＡ生合成能を持たない生物へのＥＰＡ生合成能の賦
与を目的としており、ひいてはＥＰＡの有利な製造法を
確立しようとするものである。
【００１１】
【課題を解決するための手段】従って本発明は、ＥＰＡ
生合成酵素群遺伝子、それを含有する発現型プラスミ
ド、該プラスミドにより形質転換された生物、及びこの
生物を用いるＥＰＡの製造法を提供する。
生合成酵素群遺伝子、それを含有する発現型プラスミ
ド、該プラスミドにより形質転換された生物、及びこの
生物を用いるＥＰＡの製造法を提供する。
【００１２】
【発明の実施の形態】本発明においては、ＥＰＡを生産
する能力を有する微生物(遺伝子源微生物)からＤＮＡを
抽出し、このＤＮＡを制限酵素で切断することによって
ＥＰＡ生合成酵素群をコードする遺伝子を切り出し、こ
れを適当なベクターに導入することによって発現型プラ
スミドを作成し、このプラスミドを用いて宿主生物体を
形質転換することによりＥＰＡ生産株を作成する。この
生物体によりＥＰＡを製造することができる。
する能力を有する微生物(遺伝子源微生物)からＤＮＡを
抽出し、このＤＮＡを制限酵素で切断することによって
ＥＰＡ生合成酵素群をコードする遺伝子を切り出し、こ
れを適当なベクターに導入することによって発現型プラ
スミドを作成し、このプラスミドを用いて宿主生物体を
形質転換することによりＥＰＡ生産株を作成する。この
生物体によりＥＰＡを製造することができる。
【００１３】遺伝子源 本発明において遺伝子源として使用できる生物は、特に
属、種あるいは株などを限定するものではないが、通常
は、シュードモナス(Pseudomonas)属、アルテロモナス
(Alteromonas)属、シーワネラ(Shewanella)属などに分
類される微生物等を用いることができる。これらの微生
物については公的微生物寄託機関で、容易に入手でき
る。
属、種あるいは株などを限定するものではないが、通常
は、シュードモナス(Pseudomonas)属、アルテロモナス
(Alteromonas)属、シーワネラ(Shewanella)属などに分
類される微生物等を用いることができる。これらの微生
物については公的微生物寄託機関で、容易に入手でき
る。
【００１４】シュードモナスに属する微生物の例とし
て、シュードモナス・ピュートリファシエンス(Pseudom
onas putrefaciens)SCRC-2181(FERM BP-2917)、SCRC-22
01(FERM BP-2916)、SCRC-2271(FERM BP-2915)、SCRC-23
41(FERM BP-2918)、SCRC-2451(FERM BP-2919)、SCRC-26
42(FERM BP-2920)、SCRC-2792(FERM BP-2921)、SCRC-28
78(FERM BP-1623)、SCRC-3011(FERM BP-2913)、SCRC-30
22(FERM BP-2914)を挙げることができる。
て、シュードモナス・ピュートリファシエンス(Pseudom
onas putrefaciens)SCRC-2181(FERM BP-2917)、SCRC-22
01(FERM BP-2916)、SCRC-2271(FERM BP-2915)、SCRC-23
41(FERM BP-2918)、SCRC-2451(FERM BP-2919)、SCRC-26
42(FERM BP-2920)、SCRC-2792(FERM BP-2921)、SCRC-28
78(FERM BP-1623)、SCRC-3011(FERM BP-2913)、SCRC-30
22(FERM BP-2914)を挙げることができる。
【００１５】アルテロモナスに属する微生物の例とし
て、アルテロモナス・ピュートリファシエンス(Alterom
onas putrefaciens)SCRC-2871(FERM BP-1624)及びアル
テロモナス・ピュートリファシエンス・サブスピーシズ
・サガミファシエンス(Alteromonas putrefaciens subs
pecies sagamifaciens)SCR C-1162(FERM BP-1626)等を
挙げることができる。
て、アルテロモナス・ピュートリファシエンス(Alterom
onas putrefaciens)SCRC-2871(FERM BP-1624)及びアル
テロモナス・ピュートリファシエンス・サブスピーシズ
・サガミファシエンス(Alteromonas putrefaciens subs
pecies sagamifaciens)SCR C-1162(FERM BP-1626)等を
挙げることができる。
【００１６】シーワネラに属する微生物の例として、シ
ーワネラ・ピュートリファシエンス(Shewanella putref
aciens)SCRC-2874(FERM BP-1625)等を挙げること がで
きる。
ーワネラ・ピュートリファシエンス(Shewanella putref
aciens)SCRC-2874(FERM BP-1625)等を挙げること がで
きる。
【００１７】・ＥＰＡ生合成酵素群をコードする遺伝子
のクローニング及び発現型プラスミドの作成 本発明においては、ＥＰＡ生合成酵素群の遺伝子源の例
として、シーワネラ・ピュートリファシエンス(Shewane
lla putrefaciens)SCRC-2874(FERM BP-1625)を用いる場
合について具体的に説明する。しかしながら、前記した
ように、種々のＥＰＡ生産菌を同様にして遺伝子源とし
て使用することができることは言うまでもない。遺伝子
のクローニングの方法は実施例により詳細に説明する。
のクローニング及び発現型プラスミドの作成 本発明においては、ＥＰＡ生合成酵素群の遺伝子源の例
として、シーワネラ・ピュートリファシエンス(Shewane
lla putrefaciens)SCRC-2874(FERM BP-1625)を用いる場
合について具体的に説明する。しかしながら、前記した
ように、種々のＥＰＡ生産菌を同様にして遺伝子源とし
て使用することができることは言うまでもない。遺伝子
のクローニングの方法は実施例により詳細に説明する。
【００１８】本発明では、例えばエシェリヒャ・コリ(E
scherichia coli)や枯草菌(Bacillus subtilis)のごと
き異種宿主もしくはシーワネラ属細菌のごとき同種宿
主、あるいはさらに酵母、糸状菌等を形質転換すること
により、ＥＰＡ生産株を人為的に創製することができ
る。さらに、大豆、ひまわり、アブラナ、ごま等の高等
植物に本遺伝子を導入することにより、ＥＰＡ産生植物
を作り出すことも可能である。ＥＰＡ生合成酵素群遺伝
子の発現のための領域としては、これらの酵素の遺伝子
に本来付随している制御領域を使用することも可能であ
るが、発現量を向上させ、あるいは発現の誘導を可能に
するためには別途プロモーター／オペレーター系を用意
するのが好ましい。宿主として大腸菌を用いる場合に
は、このようなプロモーター／オペレーター系として、
trp、tac、lavUV5、PL、PR、lPP等のプロモーター／オ
ペレーター系を用いることができ、ＳＤ配列として、tr
pリーダーペプチド、lacZ、メタピロカテカ−ゼまたはc
II遺伝子等のＳＤ配列を用いることができる。さらにコ
ード領域の下流に転写ターミネーター、例えば、大腸菌
のリボゾーム遺伝子のrrnBT1T2ターミネーター等を設け
ることができる。さらに、前記遺伝子の発現において
は、サッカロミセス・セレビシエ(Saccharomyces cerev
isiae)の宿主／ベクター系を用いることができ、この場
合のプロモーターとしては酵母のアルコール脱水素酵素
遺伝子のプロモーター、酸性ホスファターゼ遺伝子のプ
ロモーター、グリセルアルデヒド-3-リン酸脱水素酵素
のプロモーター、エノラーゼ遺伝子のプロモーター等を
使用することができ、この場合のプラスミドは酵母中で
複製するための配列、及び該プラスミドを含有する酵母
を選択するための選択マーカーとしての栄養要求性マー
カー、例えばLeu、Trp、His等の要求性の配列を含有す
ることが好ましい。
scherichia coli)や枯草菌(Bacillus subtilis)のごと
き異種宿主もしくはシーワネラ属細菌のごとき同種宿
主、あるいはさらに酵母、糸状菌等を形質転換すること
により、ＥＰＡ生産株を人為的に創製することができ
る。さらに、大豆、ひまわり、アブラナ、ごま等の高等
植物に本遺伝子を導入することにより、ＥＰＡ産生植物
を作り出すことも可能である。ＥＰＡ生合成酵素群遺伝
子の発現のための領域としては、これらの酵素の遺伝子
に本来付随している制御領域を使用することも可能であ
るが、発現量を向上させ、あるいは発現の誘導を可能に
するためには別途プロモーター／オペレーター系を用意
するのが好ましい。宿主として大腸菌を用いる場合に
は、このようなプロモーター／オペレーター系として、
trp、tac、lavUV5、PL、PR、lPP等のプロモーター／オ
ペレーター系を用いることができ、ＳＤ配列として、tr
pリーダーペプチド、lacZ、メタピロカテカ−ゼまたはc
II遺伝子等のＳＤ配列を用いることができる。さらにコ
ード領域の下流に転写ターミネーター、例えば、大腸菌
のリボゾーム遺伝子のrrnBT1T2ターミネーター等を設け
ることができる。さらに、前記遺伝子の発現において
は、サッカロミセス・セレビシエ(Saccharomyces cerev
isiae)の宿主／ベクター系を用いることができ、この場
合のプロモーターとしては酵母のアルコール脱水素酵素
遺伝子のプロモーター、酸性ホスファターゼ遺伝子のプ
ロモーター、グリセルアルデヒド-3-リン酸脱水素酵素
のプロモーター、エノラーゼ遺伝子のプロモーター等を
使用することができ、この場合のプラスミドは酵母中で
複製するための配列、及び該プラスミドを含有する酵母
を選択するための選択マーカーとしての栄養要求性マー
カー、例えばLeu、Trp、His等の要求性の配列を含有す
ることが好ましい。
【００１９】高等植物への遺伝子導入においては、ベク
ターを用いる方法や直接導入法などがある。ベクターと
してはTiプラスミドや、カリフラワーモザイクウイルス
(CaMV)、ジェミニウイルス、カサバラテントウイルス、
トマトゴールデンモザイクウイルスなどのＤＮＡウイル
ス、ブロムモザイクウイルス(BMV)、タバコモザイクウ
イルス(TMV)などのＲＮＡウイルスを用いることがで
き、この場合のプロモーターとしてCaMVの35Ｓプロモー
ターなどを挙げることができる。また、プロトプラスト
への直接導入法としてリン酸カルシウム法、ポリエチレ
ングリコール法、マイクロインジェクション、エレクト
ロポレーション、リポソーム法などが挙げられる。ま
た、植物細胞への直接導入法としてパーティクルガン法
も挙げられる。
ターを用いる方法や直接導入法などがある。ベクターと
してはTiプラスミドや、カリフラワーモザイクウイルス
(CaMV)、ジェミニウイルス、カサバラテントウイルス、
トマトゴールデンモザイクウイルスなどのＤＮＡウイル
ス、ブロムモザイクウイルス(BMV)、タバコモザイクウ
イルス(TMV)などのＲＮＡウイルスを用いることがで
き、この場合のプロモーターとしてCaMVの35Ｓプロモー
ターなどを挙げることができる。また、プロトプラスト
への直接導入法としてリン酸カルシウム法、ポリエチレ
ングリコール法、マイクロインジェクション、エレクト
ロポレーション、リポソーム法などが挙げられる。ま
た、植物細胞への直接導入法としてパーティクルガン法
も挙げられる。
【００２０】さらには、本遺伝子群の一部を用いて宿主
生物体の脂肪酸組成を変革することも可能である。な
お、一般に大腸菌における特定の蛋白質の発現量は遺伝
子のコピ−数、転写効率、ｍＲＮＡの安定性、翻訳効
率、蛋白質の安定性等に影響される。遺伝子工学的技術
を用いてこれらの制御領域であるプロモーター、ＳＤ領
域、ターミネーター等を改変するためにはプラスミドは
小型である方が取り扱いが容易である。また、遺伝子の
コピー数は、その遺伝子をコードしているプラスミドの
大きさに関連し、小型である方がコピー数は増加する傾
向がある。このため、本発明の実施例で述べるＥＰＡ生
合成酵素群遺伝子を含有するＤＮＡ断片をプラスミドに
挿入し、このプラスミドのサブクローニングを反復する
ことによって該遺伝子ＤＮＡ断片中の不要部分を切除す
ることにより、一層小型のプラスミドを得ることも可能
である。この方法によって得られる、より小型化したＥ
ＰＡ生合成酵素群遺伝子も本発明に含まれる。また、酵
素の安定性や活性を高めるために、公知の手法を用い
て、遺伝子の一部塩基配列(アミノ酸配列)を変換するこ
とも可能であり、これらの変異遺伝子も本発明に含まれ
る。
生物体の脂肪酸組成を変革することも可能である。な
お、一般に大腸菌における特定の蛋白質の発現量は遺伝
子のコピ−数、転写効率、ｍＲＮＡの安定性、翻訳効
率、蛋白質の安定性等に影響される。遺伝子工学的技術
を用いてこれらの制御領域であるプロモーター、ＳＤ領
域、ターミネーター等を改変するためにはプラスミドは
小型である方が取り扱いが容易である。また、遺伝子の
コピー数は、その遺伝子をコードしているプラスミドの
大きさに関連し、小型である方がコピー数は増加する傾
向がある。このため、本発明の実施例で述べるＥＰＡ生
合成酵素群遺伝子を含有するＤＮＡ断片をプラスミドに
挿入し、このプラスミドのサブクローニングを反復する
ことによって該遺伝子ＤＮＡ断片中の不要部分を切除す
ることにより、一層小型のプラスミドを得ることも可能
である。この方法によって得られる、より小型化したＥ
ＰＡ生合成酵素群遺伝子も本発明に含まれる。また、酵
素の安定性や活性を高めるために、公知の手法を用い
て、遺伝子の一部塩基配列(アミノ酸配列)を変換するこ
とも可能であり、これらの変異遺伝子も本発明に含まれ
る。
【００２１】本発明の宿主大腸菌としては、エシェリヒ
ャ・コリK12株に由来する任意の菌株を使用することが
できる。例えば、JM83、JM101、JM103、JM105、JM109、
RR1、RB791、W3110、C600、HB101、DH1、AG1、NM554等
を使用することができる。また宿主酵母としては、AH2
2、DC5、D-13-1A、YNN140等が挙げられる。なお、本発
明の遺伝子がコードする酵素群は、宿主生物体が本来有
する生合成系により合成される高級脂肪酸をイコサペン
タエン酸に誘導できる。
ャ・コリK12株に由来する任意の菌株を使用することが
できる。例えば、JM83、JM101、JM103、JM105、JM109、
RR1、RB791、W3110、C600、HB101、DH1、AG1、NM554等
を使用することができる。また宿主酵母としては、AH2
2、DC5、D-13-1A、YNN140等が挙げられる。なお、本発
明の遺伝子がコードする酵素群は、宿主生物体が本来有
する生合成系により合成される高級脂肪酸をイコサペン
タエン酸に誘導できる。
【００２２】本発明の実施に当たっては、本発明の遺伝
子を有する形質転換された生物体を常法により、例えば
微生物を用いる場合、培地で培養して微生物菌体を得
る。この際の培地としては例えば次の表１に示す組成の
培地を調製することができる。
子を有する形質転換された生物体を常法により、例えば
微生物を用いる場合、培地で培養して微生物菌体を得
る。この際の培地としては例えば次の表１に示す組成の
培地を調製することができる。
【００２３】
【表１】
【００２４】このようにして得た菌体から、通常の方法
により、例えば有機溶媒を用いて抽出することによりＥ
ＰＡを得ることができる。次に本発明を実施例によりさ
らに具体的に説明する。
により、例えば有機溶媒を用いて抽出することによりＥ
ＰＡを得ることができる。次に本発明を実施例によりさ
らに具体的に説明する。
【００２５】
実施例１−１. ＥＰＡ生合成酵素群をコ−ドする遺伝
子を含むゲノムＤＮＡの調製 シーワネラ・ピュートリファシエンス(Shewanella putr
efaciens)ＳＣＲＣ−２８７４(FERM BP-1625)を125mlの
培地（1%ペプトン、0.5%酵母エキス/1/2濃度人工海水)
に植菌し、15℃で18時間振盪培養した(OD610=8.6)。得
られた菌体を1MNaClで1回洗浄後、20mlの1M NaClに懸濁
した。これを55℃で30分静置後、0.1MEDTA 20mlを加
え、さらに55℃で15分静置後、10,000r.p.m.で10分間遠
心分離した。沈澱に100mgのリゾチームを含むTES緩衝液
(1mM EDTA, 0.1mM NaCl, 10mM Tris-HCl, pH 8.0)10ml
を加えて懸濁し、37℃で1時間静置後、10%SDS 1mlを加
えて60℃で1時間静置した。ここに中和フェノール 11ml
を加えて5分間ゆっくり振盪したのち、6,500r.p.m.で5
分間遠心分離して、上層を採取し、エタノール 20mlを
加えて軽く振り混ぜた。析出したＤＮＡをガラス棒で巻
取り、エタノール中で洗った後、10mlのTES緩衝液に溶
解して、４℃で一晩放置した。これにRNase A 0.5mgを
加えて37℃で3時間ゆっくり振盪したのち、プロテイナ
ーゼＫ 1mgを加えてさらに4.5時間振盪した。ここに中
和フェノールとクロロホルム各5mlを加えて5分間ゆっく
り振盪し、遠心分離して上層を採り、クロロホルム 10m
lを加えて5分間ゆっくり振盪し、遠心分離して上層を得
た。ここにエタノール 20mlを加えて軽く振り混ぜ、析
出したＤＮＡをガラス棒で巻取った。これをエタノール
中で洗って、3mlのＴＥＳ緩衝液に溶解した。得られた
ＤＮＡ量は約2.8mgであった。このＤＮＡ 200μgを制限
酵素Sau3AIを用いて部分分解した後、0.3%アガロースゲ
ル上で電気泳動し、約20kb以上のＤＮＡ断片を、電気溶
出により単離した。これをフェノール／クロロホルム抽
出したのちエタノール沈澱し、500μlのTE緩衝液(1mM E
DTA, 10mM Tris-HCl, pH 7.4)に溶解した。
子を含むゲノムＤＮＡの調製 シーワネラ・ピュートリファシエンス(Shewanella putr
efaciens)ＳＣＲＣ−２８７４(FERM BP-1625)を125mlの
培地（1%ペプトン、0.5%酵母エキス/1/2濃度人工海水)
に植菌し、15℃で18時間振盪培養した(OD610=8.6)。得
られた菌体を1MNaClで1回洗浄後、20mlの1M NaClに懸濁
した。これを55℃で30分静置後、0.1MEDTA 20mlを加
え、さらに55℃で15分静置後、10,000r.p.m.で10分間遠
心分離した。沈澱に100mgのリゾチームを含むTES緩衝液
(1mM EDTA, 0.1mM NaCl, 10mM Tris-HCl, pH 8.0)10ml
を加えて懸濁し、37℃で1時間静置後、10%SDS 1mlを加
えて60℃で1時間静置した。ここに中和フェノール 11ml
を加えて5分間ゆっくり振盪したのち、6,500r.p.m.で5
分間遠心分離して、上層を採取し、エタノール 20mlを
加えて軽く振り混ぜた。析出したＤＮＡをガラス棒で巻
取り、エタノール中で洗った後、10mlのTES緩衝液に溶
解して、４℃で一晩放置した。これにRNase A 0.5mgを
加えて37℃で3時間ゆっくり振盪したのち、プロテイナ
ーゼＫ 1mgを加えてさらに4.5時間振盪した。ここに中
和フェノールとクロロホルム各5mlを加えて5分間ゆっく
り振盪し、遠心分離して上層を採り、クロロホルム 10m
lを加えて5分間ゆっくり振盪し、遠心分離して上層を得
た。ここにエタノール 20mlを加えて軽く振り混ぜ、析
出したＤＮＡをガラス棒で巻取った。これをエタノール
中で洗って、3mlのＴＥＳ緩衝液に溶解した。得られた
ＤＮＡ量は約2.8mgであった。このＤＮＡ 200μgを制限
酵素Sau3AIを用いて部分分解した後、0.3%アガロースゲ
ル上で電気泳動し、約20kb以上のＤＮＡ断片を、電気溶
出により単離した。これをフェノール／クロロホルム抽
出したのちエタノール沈澱し、500μlのTE緩衝液(1mM E
DTA, 10mM Tris-HCl, pH 7.4)に溶解した。
【００２６】実施例１−２. 染色体ＤＮＡ断片のベク
ターへの挿入 ベクターとしてコスミドpWE15(STRATAGENE社製)を用い
た。10μgのpWE15を制限酵素BamHIにより完全分解し、
仔牛小腸アルカリフォスファターゼで37℃で1時間処理
し、フェノール／クロロホルムで抽出した。これをエタ
ノール沈澱し、10μlのTE緩衝液に溶解した。上記の方
法により得られたベクターＤＮＡ 1.5μgと、実施例１
で調製した染色体ＤＮＡの制限酵素Sau3AI部分分解物1
μgを混合し、T4DNAリガーゼにより、26℃で10分間反応
させてＤＮＡ鎖を連結した。この反応物の1/4量を常法
によりパッケージングしてファージとし、大腸菌K12/AG
-1株に感染させた。
ターへの挿入 ベクターとしてコスミドpWE15(STRATAGENE社製)を用い
た。10μgのpWE15を制限酵素BamHIにより完全分解し、
仔牛小腸アルカリフォスファターゼで37℃で1時間処理
し、フェノール／クロロホルムで抽出した。これをエタ
ノール沈澱し、10μlのTE緩衝液に溶解した。上記の方
法により得られたベクターＤＮＡ 1.5μgと、実施例１
で調製した染色体ＤＮＡの制限酵素Sau3AI部分分解物1
μgを混合し、T4DNAリガーゼにより、26℃で10分間反応
させてＤＮＡ鎖を連結した。この反応物の1/4量を常法
によりパッケージングしてファージとし、大腸菌K12/AG
-1株に感染させた。
【００２７】実施例１−３． 組み換え体のＥＰＡ生産
株の検索 実施例１−２のファージ感染させた大腸菌液を、50μg/
mlのアンピシリンを含むLB寒天培地(トリプトン1%、酵
母エキス0.5%、NaCl 1%、寒天 2%)に塗布し、37℃で一
晩培養した。出現したコロニーを、50μg/mlのアンピシ
リンを含む1.5mlのLB培地に接種し、25℃で1〜7日間振
盪培養した。これを遠心分離して菌体を集め、培地を除
いた後、塩化水素飽和のメタノール0.5mlに懸濁し、密
栓して80℃で1時間保温して脂肪酸をメチルエステル化
した。放冷後、0.3mlのヘキサンで3回抽出し、ヘキサン
層を乾固して20μlのメタノールに溶解した。その2μl
をシリカゲルプレートにスポットし、ヘキサンとエーテ
ルの19:1の展開溶媒で3回展開したのち風乾し、ヨード
発色を行った。このようにして、組み換え体390株につ
いて検索を行った結果、スタンダードのＥＰＡのメチル
エステルと同位置に薄層クロマトグラフィースポットを
示す株を1株得た。この株よりコスミドをアルカリ/SDS
法を用いて抽出した。このコスミドをｐＥＰＡと名付け
た。ｐＥＰＡは、pWE15のBamHI部位に約38KbpのSau3AI
切断断片が挿入されたコスミドであった。
株の検索 実施例１−２のファージ感染させた大腸菌液を、50μg/
mlのアンピシリンを含むLB寒天培地(トリプトン1%、酵
母エキス0.5%、NaCl 1%、寒天 2%)に塗布し、37℃で一
晩培養した。出現したコロニーを、50μg/mlのアンピシ
リンを含む1.5mlのLB培地に接種し、25℃で1〜7日間振
盪培養した。これを遠心分離して菌体を集め、培地を除
いた後、塩化水素飽和のメタノール0.5mlに懸濁し、密
栓して80℃で1時間保温して脂肪酸をメチルエステル化
した。放冷後、0.3mlのヘキサンで3回抽出し、ヘキサン
層を乾固して20μlのメタノールに溶解した。その2μl
をシリカゲルプレートにスポットし、ヘキサンとエーテ
ルの19:1の展開溶媒で3回展開したのち風乾し、ヨード
発色を行った。このようにして、組み換え体390株につ
いて検索を行った結果、スタンダードのＥＰＡのメチル
エステルと同位置に薄層クロマトグラフィースポットを
示す株を1株得た。この株よりコスミドをアルカリ/SDS
法を用いて抽出した。このコスミドをｐＥＰＡと名付け
た。ｐＥＰＡは、pWE15のBamHI部位に約38KbpのSau3AI
切断断片が挿入されたコスミドであった。
【００２８】実施例１−４. ｐＥＰＡの制限酵素地図
の作成 コスミドｐＥＰＡを、形質転換菌AG-1/ｐＥＰＡより調
製した。ｐＥＰＡを種々の制限酵素で切断し、制限酵素
切断地図を作成した（図１）。
の作成 コスミドｐＥＰＡを、形質転換菌AG-1/ｐＥＰＡより調
製した。ｐＥＰＡを種々の制限酵素で切断し、制限酵素
切断地図を作成した（図１）。
【００２９】実施例１−５. 配列の解析 コスミドｐＥＰＡ中のゲノムＤＮＡ挿入部を含むSau3AI
-Sau3AI断片の全塩基配列を配列番号：１に示す。この
塩基配列中には９個のオープンリーディングフレーム(O
RF)：２〜１０を特定することができ、これらのそれぞ
れの塩基配列及び対応するアミノ酸配列を配列番号：２
〜１０に示す。全塩基配列(配列番号：１)とＯＲＦ２〜
１０(それぞれ配列番号：２〜１０)との関係は表２の通
りである。
-Sau3AI断片の全塩基配列を配列番号：１に示す。この
塩基配列中には９個のオープンリーディングフレーム(O
RF)：２〜１０を特定することができ、これらのそれぞ
れの塩基配列及び対応するアミノ酸配列を配列番号：２
〜１０に示す。全塩基配列(配列番号：１)とＯＲＦ２〜
１０(それぞれ配列番号：２〜１０)との関係は表２の通
りである。
【００３０】
【表２】 配列番号 配列の長さ 配列番号１に対する配列の位置 ───────────────────────── ２ 1983 6121-8103 ４ 831 9016-8186* ６ 2910 9681-12590 ８ 864 13040-13903 10 8268 13906-22173 12 2340 22176-24515 14 6012 24518-30529 16 1629 30730-32358 18 1575 32753-34327 ─────────────────────────* 配列番号：１の配列位置8186-9016の逆配列
【００３１】前記種々のＯＲＦのアミノ酸配列と既知ア
ミノ酸配列とを比較したところ、ＯＲＦ６中の５領域
（重複領域有り）及びＯＲＦ８中の２領域が脂肪酸合成
に関与する酵素のアミノ酸配列とある程度相同性を有す
ることが見出された。その結果を次の表３に示す。
ミノ酸配列とを比較したところ、ＯＲＦ６中の５領域
（重複領域有り）及びＯＲＦ８中の２領域が脂肪酸合成
に関与する酵素のアミノ酸配列とある程度相同性を有す
ることが見出された。その結果を次の表３に示す。
【００３２】
【表３】 配列番号 アミノ酸 類似酵素及び位置 文献 (ORF番号) 配列の位置 ───────────────────────────────── 10 668(Leu)-930(Leu) マロニルCoA-ACP トランス (1) (ORF6) フェラーゼ56(Leu)-309(Leu) 10 189(Phe)-424(His) 脂肪酸合成酵素120(Phe)-350(His) (2) (ORF6) 10 200(Ser)-483(Leu) 脂肪酸合成酵素(3-ケトアシル-ACP (3) (ORF6) シンセターゼドメイン)137(Ala)-406(Asp) 10 204(Ser)-488(Gln) 3-ケトアシル-ACPシンセターゼ (4) (ORF6) 137(Ala)-406(Asp) 10 2261(Phe)-2392(Gly) 2-オキソアシルレダクターゼ (5) (ORF6) 1470(Leu)-1604(Gly) 14 205(Ala)-442(Lys) 3-ケトアシル-ACPシンセターゼ (6) (ORF8) 187(Ala)-416(Asn) 14 1373(Thr)-1547(Val) 3-ヒドロキシデカノイル-ACPデヒド (7) (ORF8) ラタ−ゼ29(Leu)-163(Val) ───────────────────────────────── 文献 (1) Magnuson K. et al., FEBS Lett. (1992) 299:262-266 (2) Kameda K. et al., J. Biol. Chem. (1991) 266:419-426 (3) Huang W. Y. et al., Arch. Biochem. Biophys. (1989) 270:92-98 (4) Kauppinen S. et al., Carlsberg Res. Commun. (1988) 53:357-370 (5) Beck J. et al., Eur. J. Biochem. (1990) 192:487-498 (6) Siggaard-Andersen M. et al., Proc. Natl. Acad.Sci. U.S.A. (1991) 88 :4114-4118 (7) Cronan Jr. J. E. et al., J. Biol. Chem. (1988) 263:4641-4646
【００３３】従って、本発明は、配列番号：４、８、１
０、１４、１８に示すアミノ酸配列をコードする遺伝子
を提供すると共に、前記の既知酵素のアミノ酸配列と相
同性を有するアミノ酸配列領域又はこれを含むアミノ酸
配列をコードするＤＮＡをも提供する。
０、１４、１８に示すアミノ酸配列をコードする遺伝子
を提供すると共に、前記の既知酵素のアミノ酸配列と相
同性を有するアミノ酸配列領域又はこれを含むアミノ酸
配列をコードするＤＮＡをも提供する。
【００３４】実施例２. 形質転換菌ＡＧ−１／ｐＥＰ
ＡによるＥＰＡの生産 形質転換菌AG-1/ｐＥＰＡを、50μl/mlのアンピシリン
を含むLB培地100mlに接種し、25℃で48時間培養した。
遠心分離により菌体を得、1回洗浄したのち純水2mlに懸
濁して、クロロホルムとメタノールの2対1の溶媒12mlで
3回抽出した。溶媒層を乾固し、塩化水素飽和のメタノ
ール1.5mlに溶解して密閉容器に入れ、80℃で1時間保温
して脂肪酸をメチルエステル化した。放冷後、ヘキサン
2mlで3回抽出し、ヘキサン層を乾固して20μlのメタノ
ールに溶解した。この溶解物の一部をガスクロマトグラ
フィーにより分析したところ、ＥＰＡのピークが観察さ
れ、その全脂肪酸エステル中における割合は、ピークの
面積比から約1.36%と算出された。培養当りのＥＰＡ生
成量は、約0.5mg/lであった。得られたエステル混合物
を硝酸銀シリカゲルプレートにスポットし、ヘキサンと
エーテルの3対1の溶媒で展開した。これをフルオロセイ
ン及び紫外線で発色させ、高度不飽和脂肪酸エステル画
分のスポットをかき取って、メタノール1.8ml, 10%NaCl
0.2mlを加えて室温で30分間振盪した。これをヘキサン
2mlで3回抽出し、ヘキサン層を乾固して40μlのヘキサ
ンに溶解して、GC-MS分析を行ったところ、ガスクロマ
トグラフィー上の目的ピークの物質の分子量は316であ
り、各フラグメントのピークは標品のそれと全く一致
し、本物質はＥＰＡと同定された。なお、MSフラグメン
トピークは以下の通りであった。
ＡによるＥＰＡの生産 形質転換菌AG-1/ｐＥＰＡを、50μl/mlのアンピシリン
を含むLB培地100mlに接種し、25℃で48時間培養した。
遠心分離により菌体を得、1回洗浄したのち純水2mlに懸
濁して、クロロホルムとメタノールの2対1の溶媒12mlで
3回抽出した。溶媒層を乾固し、塩化水素飽和のメタノ
ール1.5mlに溶解して密閉容器に入れ、80℃で1時間保温
して脂肪酸をメチルエステル化した。放冷後、ヘキサン
2mlで3回抽出し、ヘキサン層を乾固して20μlのメタノ
ールに溶解した。この溶解物の一部をガスクロマトグラ
フィーにより分析したところ、ＥＰＡのピークが観察さ
れ、その全脂肪酸エステル中における割合は、ピークの
面積比から約1.36%と算出された。培養当りのＥＰＡ生
成量は、約0.5mg/lであった。得られたエステル混合物
を硝酸銀シリカゲルプレートにスポットし、ヘキサンと
エーテルの3対1の溶媒で展開した。これをフルオロセイ
ン及び紫外線で発色させ、高度不飽和脂肪酸エステル画
分のスポットをかき取って、メタノール1.8ml, 10%NaCl
0.2mlを加えて室温で30分間振盪した。これをヘキサン
2mlで3回抽出し、ヘキサン層を乾固して40μlのヘキサ
ンに溶解して、GC-MS分析を行ったところ、ガスクロマ
トグラフィー上の目的ピークの物質の分子量は316であ
り、各フラグメントのピークは標品のそれと全く一致
し、本物質はＥＰＡと同定された。なお、MSフラグメン
トピークは以下の通りであった。
【００３５】Mass : 316(M+),287,273,262,247,234,22
0,201,180,161,148,133,119,108,93,79,67,55,41,28.
0,201,180,161,148,133,119,108,93,79,67,55,41,28.
【００３６】実施例３ 形質転換菌ＪＭ１０９／ｐＥＰ
ＡによるＥＰＡの生産 コスミドｐＥＰＡを用いて、常法により、大腸菌K12/JM
109株を形質転換した。50μl/mlのアンピシリンを含むL
B寒天培地を用いた選別によりJM109/ｐＥＰＡ(FREM BP-
4257)を得た。これから実施例２と同様にして菌体脂質
の抽出、メチルエステル化を行い、ガスクロマトグラフ
ィーにより分析したところ、ＥＰＡのピークが検出され
た。その全脂肪酸エステル中における割合は、ピークの
面積比から約1.43%と算出された。培養当りのＥＰＡ生
成量は、約0.6mg/lであった。
ＡによるＥＰＡの生産 コスミドｐＥＰＡを用いて、常法により、大腸菌K12/JM
109株を形質転換した。50μl/mlのアンピシリンを含むL
B寒天培地を用いた選別によりJM109/ｐＥＰＡ(FREM BP-
4257)を得た。これから実施例２と同様にして菌体脂質
の抽出、メチルエステル化を行い、ガスクロマトグラフ
ィーにより分析したところ、ＥＰＡのピークが検出され
た。その全脂肪酸エステル中における割合は、ピークの
面積比から約1.43%と算出された。培養当りのＥＰＡ生
成量は、約0.6mg/lであった。
【００３７】実施例４ 一部欠失ｐＥＰＡの作成とＥＰ
Ａの生産能の検討 ｐＥＰＡから種々の制限酵素を用いて配列番号：１の一
部を切り出したのちｐＥＰＡを再結合させた。また、ｐ
ＥＰＡのXhoI-SpeI断片をプラスミドpBluescript(STRAT
AGENE社製)のXhoI-SpeI部位に連結して、pXS-BSを作成
した。また、ｐＥＰＡのPacI(9061)-AatII(35564)断片
をプラスミドpNEB(New England Biolabs社製)のPacI-Aa
tII部位に連結して、pPA-NEBを作成した。さらに、ｐＥ
ＰＡのAscI(7709)-AatII(35564)断片をプラスミドpNEB
(New England Biolabs社製)のAscI-AatII部位に連結し
て、pAA-NEBを作成した。これらのプラスミドを用いて
大腸菌を形質転換した後、イコサペンタエン酸の生産性
を調べた。結果を表４及び図２に示す。
Ａの生産能の検討 ｐＥＰＡから種々の制限酵素を用いて配列番号：１の一
部を切り出したのちｐＥＰＡを再結合させた。また、ｐ
ＥＰＡのXhoI-SpeI断片をプラスミドpBluescript(STRAT
AGENE社製)のXhoI-SpeI部位に連結して、pXS-BSを作成
した。また、ｐＥＰＡのPacI(9061)-AatII(35564)断片
をプラスミドpNEB(New England Biolabs社製)のPacI-Aa
tII部位に連結して、pPA-NEBを作成した。さらに、ｐＥ
ＰＡのAscI(7709)-AatII(35564)断片をプラスミドpNEB
(New England Biolabs社製)のAscI-AatII部位に連結し
て、pAA-NEBを作成した。これらのプラスミドを用いて
大腸菌を形質転換した後、イコサペンタエン酸の生産性
を調べた。結果を表４及び図２に示す。
【００３８】
【表４】 ─────────────────────────────────── プラスミド名 欠失部位（配列位置） 欠失ＯＲＦ ＥＰＡ生産 ─────────────────────────────────── pEPAΔ2 XhoI(5666)-AscI(7709) ２ ＋ pEPAΔ4,5 SnaBI(10944)-SnaBI(13226) ４，５ ※ pEPAΔ6 BbeI(16563)-BbeI(20702) ６ − pEPAΔ7 SalI(22265)-NruI(23847) ７ − pEPAΔ8 PstI(24814)-EcoT22I(28946) ８ − pEPAΔ9 SpeI(31446)-SpeI(34626)* ９ − pEPAΔ10 NheI(32526)-SpeI(34630) １０ − pXS-BS Sau3AI(1)-XhoI(5660), − ＋ SpeI(34632)-Sau3AI(37895) pPA-NEB Sau3AI(1)-PacI(9060), ２，３ − AatII(35565)-Sau3AI(37895) pAA-NEB Sau3AI(1)-AscI(7709), ２ ＋ AatII(35565)-Sau3AI(37895) ─────────────────────────────────── ※pEPAの1/10以下 *逆配列
【００３９】上記の結果より、ＯＲＦ２の上流領域、Ｏ
ＲＦ１０の下流領域、及びＯＲＦ２はＥＰＡ合成に関与
しないことが示唆され、一方ＯＲＦ３、６、７、８、
９、１０はＥＰＡ合成に必須であり、ＯＲＦ４と５のう
ち少なくとも１つはＥＰＡ合成に関与していることが示
唆された。
ＲＦ１０の下流領域、及びＯＲＦ２はＥＰＡ合成に関与
しないことが示唆され、一方ＯＲＦ３、６、７、８、
９、１０はＥＰＡ合成に必須であり、ＯＲＦ４と５のう
ち少なくとも１つはＥＰＡ合成に関与していることが示
唆された。
【００４０】実施例５ 各ＯＲＦクローンのサブクロー
ニング ｐＥＰＡのＯＲＦのうち４、７、８、及び９をｐＵＣ１
１８にサブクローニングを行った。ＯＲＦ４、８、及び
９については、ＰＣＲ(polymerase chain reaction)を
用いて翻訳開始点より上流のＤＮＡ配列の短いものを作
製した。それぞれサブクローニンに含まれる全塩基配列
との関係及びＰＣＲに使用したプライマーの配列は、表
５及び６の通りである。
ニング ｐＥＰＡのＯＲＦのうち４、７、８、及び９をｐＵＣ１
１８にサブクローニングを行った。ＯＲＦ４、８、及び
９については、ＰＣＲ(polymerase chain reaction)を
用いて翻訳開始点より上流のＤＮＡ配列の短いものを作
製した。それぞれサブクローニンに含まれる全塩基配列
との関係及びＰＣＲに使用したプライマーの配列は、表
５及び６の通りである。
【００４１】
【表５】 プラスミド 配列番号 配列の長さ 配列番号１に対する位置 ─────────────────────────────── pUCP2 ６ ３３６５ 9573-12937 pUCP5 12 ３４３０ 22119-25548 pUCP6 14 ７０８３ 24364-31446 pUCP7 16 ２１４４ 30629-32772 pUCP8 18 ２０７０ 32557-34626 ───────────────────────────────
【００４２】
【表６】
【００４３】実施例６−１ 酵素タンパク質の調製 EPA合成能をもつ大腸菌JM109/pXS-BS、実験２で作製し
たサブクローンをプラスミドとして持つJM109を50mlのL
B-アンピシリン培地中で25℃で24時間振盪培養した。こ
れを4℃で3,000r.p.m.(Hitachi RPR-20-2)20分遠心して
菌体を集め、10mlの10mM PKB(10mM リン酸カリウム緩衝
液、pH7.0、2mM β-メルカプトエタノール、10mM EDTA)
に懸濁し、4℃で3,000r.p.m.、10分遠心して洗った。こ
の沈殿を2mlの10mM PKBに懸濁し、超音波破砕の後、4℃
で33,000r.p.m.(Beckmann, SW55)、80分遠心して得た上
清を酵素タンパク質として用いた。
たサブクローンをプラスミドとして持つJM109を50mlのL
B-アンピシリン培地中で25℃で24時間振盪培養した。こ
れを4℃で3,000r.p.m.(Hitachi RPR-20-2)20分遠心して
菌体を集め、10mlの10mM PKB(10mM リン酸カリウム緩衝
液、pH7.0、2mM β-メルカプトエタノール、10mM EDTA)
に懸濁し、4℃で3,000r.p.m.、10分遠心して洗った。こ
の沈殿を2mlの10mM PKBに懸濁し、超音波破砕の後、4℃
で33,000r.p.m.(Beckmann, SW55)、80分遠心して得た上
清を酵素タンパク質として用いた。
【００４４】実施例６−２ 炭素鎖の伸張に関する酵素
反応と活性の検出 酵素反応は、[1-14C]stearoyl-CoA(19nmole/μCi)及びs
tearoyl-CoA合わせて25μM、25μM malonyl-CoA、100μ
g大腸菌アシルキャリアープロテイン(ACP)、1.5mM NADP
H、1.5mM NADH、10μM セルレニン、20μM PMSF、実施
例６−１で得た酵素タンパク質250μgを含む0.1M リン
酸カリウム緩衝液(pH7.0)0.5ml中で25℃で30分間振盪し
ながら行った。反応液を一晩凍結乾燥したものに、8%HC
l-methanol 1mlを加え80℃で1時間処理して含まれる脂
肪酸をエステル化した。これを1mlのn-ヘキサンで3回抽
出し、n-ヘキサンを真空中で蒸発させた。その残渣に0.
2mlのn-ヘキサンを加えて3回抽出した。最終的に濃縮さ
れたn-ヘキサン溶液の一部を逆相TLC(MERCK RP-8F254S)
にキャリアーのステアリン酸及びアラキジン酸のそれぞ
れメチルエステルとともにスポットし、アセトニトリ
ル：水(7:1、v/v)で25分間3回展開した。このTLCプレー
トのアイソトープの分布をAMBIS-RIイメージングシステ
ム及びオートラジオグラフィーで調べた。
反応と活性の検出 酵素反応は、[1-14C]stearoyl-CoA(19nmole/μCi)及びs
tearoyl-CoA合わせて25μM、25μM malonyl-CoA、100μ
g大腸菌アシルキャリアープロテイン(ACP)、1.5mM NADP
H、1.5mM NADH、10μM セルレニン、20μM PMSF、実施
例６−１で得た酵素タンパク質250μgを含む0.1M リン
酸カリウム緩衝液(pH7.0)0.5ml中で25℃で30分間振盪し
ながら行った。反応液を一晩凍結乾燥したものに、8%HC
l-methanol 1mlを加え80℃で1時間処理して含まれる脂
肪酸をエステル化した。これを1mlのn-ヘキサンで3回抽
出し、n-ヘキサンを真空中で蒸発させた。その残渣に0.
2mlのn-ヘキサンを加えて3回抽出した。最終的に濃縮さ
れたn-ヘキサン溶液の一部を逆相TLC(MERCK RP-8F254S)
にキャリアーのステアリン酸及びアラキジン酸のそれぞ
れメチルエステルとともにスポットし、アセトニトリ
ル：水(7:1、v/v)で25分間3回展開した。このTLCプレー
トのアイソトープの分布をAMBIS-RIイメージングシステ
ム及びオートラジオグラフィーで調べた。
【００４５】その結果、pUCO5及びpUCP6の培養により得
られた酵素タンパク質を加えた場合にステアリン酸の炭
素鎖が2個伸張したアラキジン酸メチルエステル付近の
スポットが見られた。TLCで見られたアラキジン酸メチ
ルエステル付近のスポットの確認のために、ラジオガス
クロマトグラフィー(RGLC)を行った。RGLCは、5%シンク
ロームE-71のガラスカラム2m、検出にはFID(N2:60ml/mi
n)とRI側(CH4:250ml/min)には通気型比例計数管を用い
た(3,400V)。通常の1反応の約3分の2に当たるものをRGL
Cにかけた。その結果、ORF7、ORF8のうちいずれか1個を
持つプラスミドpUCO5及びpUCP6由来のものにアラキジン
酸メチルエステルに相当するピークが見られた。そのピ
ークの放射活性を表７に示す。これらのORFには、ステ
アリン酸(C18)をアラキジン酸(C20)に伸張させる活性が
存在した。
られた酵素タンパク質を加えた場合にステアリン酸の炭
素鎖が2個伸張したアラキジン酸メチルエステル付近の
スポットが見られた。TLCで見られたアラキジン酸メチ
ルエステル付近のスポットの確認のために、ラジオガス
クロマトグラフィー(RGLC)を行った。RGLCは、5%シンク
ロームE-71のガラスカラム2m、検出にはFID(N2:60ml/mi
n)とRI側(CH4:250ml/min)には通気型比例計数管を用い
た(3,400V)。通常の1反応の約3分の2に当たるものをRGL
Cにかけた。その結果、ORF7、ORF8のうちいずれか1個を
持つプラスミドpUCO5及びpUCP6由来のものにアラキジン
酸メチルエステルに相当するピークが見られた。そのピ
ークの放射活性を表７に示す。これらのORFには、ステ
アリン酸(C18)をアラキジン酸(C20)に伸張させる活性が
存在した。
【００４６】
【表７】 プラスミド 配列番号 ＣＰＭ ─────────────────── pUCP2 ６ 15.8 pUCP5 12 42.0 pUCP6 14 29.0 pUCP7 16 9.0 pUCP8 18 9.2 ───────────────────
【００４７】
配列番号： １ 配列の長さ：３７８９５ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GATCTCTTAC AAAGAAACTA TCTCAATGTG AATTTAACCT TAATTCCGTT TAATTACGGC 60 CTGATAGAGC ATCACCCAAT CAGCCATAAA ACTGTAAAGT GGGTACTCAA AGGTGGCTGG 120 GCGATTCTTC TCAAATACAA AGTGCCCAAC CCAAGCAAAT CCATATCCGA TAACAGGTAA 180 AAGTAGCAAT AAACCCCAGC GCTGAGTTAG TAATACATAA GCGAATAATA GGATCACTAA 240 ACTACTGCCG AAATAGTGTA ATATTCGACA GTTTCTATGC TGATGTTGAG ATAAATAAAA 300 AGGGTAAAAT TCAGCAAAAG AACGATAGCG CTTACTCATT ACTCACACCT CGGTAAAAAA 360 GCAACTCGCC ATTAACTTGG CCAATCGTCA GTTGTTCTAT CGTCTCAAAG TTATGCCGAC 420 TAAATAACTC TATATGTGCA TTATGATTAG CAAAAACTCC GATACCATCA AGATGAAGTT 480 GTTCATCACA CCAACTCAAA ACTGCGTCGA TAAGCTTACT GCCATAGCCC TTGCCTTGCT 540 CCACATTTGC GATAGCAATA AACTGTAAAA TGCCACATTG GCCACTTGGT AAGCTCTCTA 600 TAATCTGATT TTCTTTGTTA ATAAGTGCCT GAGTTGAATA CCAACCAGTA CTTAACAACA 660 TCTTTAAACG CCAATGCCAA AAACGCGCTT CACCTAAGGG AACCTGCTGA GTCACTATGC 720 AGGCTACGCC TATCAATCTA TCCCCAACGA ACATACCAAT AAGTGCTTGC TCCTGTTGCC 780 AGAGCTCATT GAGTTCTTCT CGAATAGCCC CGCGAAGCTT TTGCTCATAC TGCGCTTGAT 840 CACCACTAAA AAGTGTTTCG ATAAAAAAGG GATCATCATG ATAGGCGTTA TAGAGAATAG 900 AGGCTGCTAT GCGTAAATCT TCTGCCGTGA GATAAACTGC ACGACACTCT TCCATGGCTT 960 GATCTTCCAT TGTTATTGTC CTTGACCTTG ATCACACAAC ACCAATGTAA CAAGACTGTA 1020 TAGAAGTGCA ATTAATAATC AATTCGTGCA TTAAGCAGGT CAGCATTTCT TTGCTAAACA 1080 AGCTTTATTG GCTTTGACAA AACTTTGCCT AGACTTTAAC GATAGAAATC ATAATGAAAG 1140 AGAAAAGCTA CAACCTAGAG GGGAATAATC AAACAACTGC TAAGATCTAG ATAATGTAAT 1200 AAACACCGAG TTTATCGACC ATACTTAGAT AGAGTCATAG CAACGAGAAT AGTTATGGAT 1260 ACAACGCCGC AAGATCTATC ACACCTGTTT TTACAGCTAG GATTAGCAAA TGATCAACCC 1320 GCAATTGAAC AGTTTATCAA TGACCATCAA TTAGCGGACA ATATATTGCT ACATCAAGCA 1380 AGCTTTTGGA GCCCATCGCA AAAGCACTTC TTAATTGAGT CATTTAATGA AGATGCCCAG 1440 TGGACCGAAG TCATCGACCA CTTAGACACC TTATTAAGAA AAAACTAACC ATTACAACAG 1500 CAACTTTAAA TTTTGCCGTA AGCCATCTCC CCCCACCCCA CAACAGCGTT GTTGCTTATG 1560 ACCACTGGAG TACATTCGTC TTTAGTCGTT TTACCATCAC CATGGGTACG TTGAGTGCGA 1620 TAAAAAAGCA CATAAACTTC TTTATCGGCC TGAATATAGG CTTCGTTAAA ATCAGCTGTT 1680 CCCATTAAAG TAACCACTTG CTCTTTACTC ATGCCTAGAG ATATCTTTGT CAAATTGTCA 1740 CGGTTTTTAT CTTGAGTTTT CTCCCAAGCA CCGTGATTAT CCCAGTCAGA TTCCCCATCA 1800 CCAACATTGA CCACACAGCC CGTTAGCCCT AAGCTTGCAA TCCCAAAACA TGCTAAACCT 1860 AATAATTTAT TTTTCATTTT AACTTCCTGT TATGACATTA TTTTTGCTTA GAAGAAAAGC 1920 AACTTACATG CCAAAACACA AGCTGTTGTT TTAAATGACT TTATTTATTA TTAGCCTTTT 1980 AGGATATGCC TAGAGCAATA ATAATTACCA ATGTTTAAGG AATTTGACTA ACTATGAGTC 2040 CGATTGAGCA AGTGCTAACA GCTGCTAAAA AAATCAATGA ACAAGGTAGA GAACCAACAT 2100 TAGCATTGAT TAAAACCAAA CTTGGTAATA GCATCCCAAT GCGCGAGTTA ATCCAAGGTT 2160 TGCAACAGTT TAAGTCTATG AGTGCAGAAG AAAGACAAGC AATACCTAGC AGCTTAGCAA 2220 CAGCAAAAGA AACTCAATAT GGTCAATCAA GCTTATCTCA ATCTGAACAA GCTGATAGGA 2280 TCCTCCAGCT AGAAAACGCC CTCAATGAAT TAAGAAACGA ATTTAATGGG CTAAAAAGTC 2340 AATTTGATAA CTTACAACAA AACCTGATGA ATAAAGAGCC TGACACCAAA TGCATGTAAT 2400 TGAACTACGA TTTGAATGTT TTGATAACAC CACGATTACT GCAGCAGAAA AAGCCATTAA 2460 TGGTTTGCTT GAAGCTTATC GAGCCAATGG CCAGGTTCTA GGTCGTGAAT TTGCCGTTGC 2520 ATTTAACGAT GGTGAGTTTA AAGCACGCAT GTTAACCCCA GAAAAAAGCA GCTTATCTAA 2580 ACGCTTTAAT AGTCCTTGGG TAAATAGTGC ACTCGAAGAG CTAACCGAAG CCAAATTGCT 2640 TGCGCCACGT GAAAAGTATA TTGGCCAAGA TATTAATTCT GAAGCATCTA GCCAAGACAC 2700 ACCAAGTTGG CAGCTACTTT ACACAAGTTA TGTGCACATG TGCTCACCAC TAAGAAATGG 2760 CGACACCTTG CAGCCTATTC CACTGTATCA AATTCCAGCA ACTGCCAACG GCGATCATAA 2820 ACGAATGATC CGTTGGCAAA CAGAATGGCA AGCTTGTGAT GAATTGCAAA TGGCCGCAGC 2880 TACTAAAGCT GAATTTGCCG CACTTGAAGA GCTAACCAGT CATCAGAGTG ATCTATTTAG 2940 GCGTGGTTGG GACTTACGTG GCAGAGTCGA ATACTTGACG AAAATTCCGA CCTATTACTA 3000 TTTATACCGT GTTGGCGGTG AAAGCTTAGC AGTAGAAAAG CAGCGCTCTT GTCCTAAGTG 3060 TGGCAGTCAA GAATGGCTGC TCGATAAACC ATTATTGGAT ATGTTCCATT TTCGCTGTGA 3120 CACCTGCCGC ATCGTATCTA ATATCTCTTG GGACCATTTA TAACTCTTCC GAGTCTTATC 3180 ACACTAGAGT TTAGTCAGCA TAAAAATGGC GCTTATATTT CAATTAAAAG AAATATAAGC 3240 GCCATTTTCA TCGATACTAT ATATCAGCAG ACTATTTTCC GCGTAAATTA GCCCACATTA 3300 ATTTCATTCT TTGCCAGATC CCTGGATGAT CTAGTTGTGG CATCGACTCT TCAATAGGTT 3360 TAACCGCAGG TGTAACCCTT GGAGTCAATT CGTTTATAAA CTCGTTTAAA CTGTCACTTA 3420 ATTTAACGCT TTGTACTTCA CCTGGAATTT CAATCCATAC GCTGCCATCA CTATTATTAA 3480 CCGTCAACAT TTTATCTTCA TCATCAAGAA TACCAATAAA CCAAGTCGGC TCTTGCTTAA 3540 GCTTTCTCTT CATCATTAAA TGACCAATGA TGTTTTGTTG TAAGTATTCA AAATCAGTTT 3600 GATCCCACAC TTGGATTAGC TCACCTTGGC CCCATTGTGA GTCAAAAAAT AGCGGTGCAG 3660 AAAAATGACT GCCAAAAAAT GGATTAATTT CTGCAGATAA TGTCATTTCA AGTGCTGTTT 3720 CAACATTAGC AAATTCACCA GGTTGTTGAC GTACAACCGA TTGCCAAAAC ACTGCGCCAT 3780 CGGAGCCCGC TTCGGCGACA ACACACTCAG ACTTTTGTCC TTGCGCATAA TATCTTGGCT 3840 GTTCACCAAG CTTATCCATG TAGGCTTGTT GATATTTAGA TAAAAAAAGA TCTAAAGCAG 3900 GTAAAGAAGA CACTTAAGCC AGTTCCAAAA TCAGTTATAA TAGGGGTCTA TTTTGACATG 3960 GAAACCGTAT TGATGACACA ACATCATGAT CCCTACAGTA ACGCCCCCGA ACTTTCTGAA 4020 TTAACTTTAG GAAAGTCGAC CGGTTATCAA GAGCAGTATG ATGCATCTTT ACTACAAGCG 4080 TGCCGCGTAA ATTAAACCGT GATGCTATCG GTCTAACCAA TGAGCTACCT TTTCATGGCT 4140 GTGATATTTG GACTGGCTAC GAACTGTCTT GGCTAAATGC TAAAGGCAAG CCAATGATTG 4200 CTATTGCAGA CTTTAACCTA AGTTTTGATA GTAAAAATCT GATCGAGTCT AAGTCGTTTA 4260 AGCTGTATTT AAACAGCTAT AACCAAACAC GATTTGATAG CGTTCAAGCG GTTCAAGAAC 4320 GTTTAACTGA AGACTTAAGC GCCTGTGCCC AAGGCACAGT TACGGTAAAA GTGATTGAAC 4380 CTAAGCAATT TAACCACCTG AGAGTGGTTG ATATGCCAGG TACCTGCATT GACGATTTAG 4440 ATATTGAAGT TGATGACTAT AGCTTTAACT CTGACTATCT CACCGACAGT GTTGATGACA 4500 AAGTCATGGT TGCTGAAACG CTAACGTCAA ACTTATTGAA ATCAAACTGC CTAATCACTT 4560 CTCAGCCTGA CTGGGGTACA GTGATGATCC GTTATCAAGG GCCTAAGATA GACCGTGAAA 4620 AGCTACTTAG ATATCTGATT TCATTTAGAC AGCACAATGA ATTTCATGAG CAGTGTGTTG 4680 AGCGTATATT TGTTGATTTA AAGCACTATT GCCAATGTGC CAAACTTACT GTCTATGCAC 4740 GTTATACCCG CCGTGGTGGT TTAGATATCA ACCCATATCG TAGCGACTTT GAAAACCCTG 4800 CAGAAAATCA GCGCCTAGCG AGACAGTAAT TGATTGCAGT ACCTACAAAA AACAATGCCT 4860 ATAAGCCAAG CTTATGGGCA TTTTTATATT ATCAACTTGT CATCAAACCT CAGCCGCCAA 4920 GCCTTTTAGT TTTATCGCTA AATTAAGCCG CTCTCTCAGC CAAATATTTG CAGGATTTTG 4980 CTGTAATTTA TGGCTCCACA CCATGAAATA CTCTATCGGC TCTACCGCAA AAGGTAAGTC 5040 AAATACCTGT AAGCCAAACA GCTTGGCATA TTCGTCAGTG TGGGCTTTTG ACGCGATAGC 5100 TAACGCATCA CTTTTTGAGG CAACCGACAT CATACTTAAT ATTGATGATT GCTCGCTGTG 5160 CATTTGCCTT GCCGGTAACA CCTGTTTAGT CAGCAAGTCG GCAACACTTA AATTGTAGCG 5220 GCGCATCTTA AAAATAATAT GCTTTTCATT AAAGTATTGC TCTTGCGTCA ACCCACCTTG 5280 GATCCTTGGG TGAGCATTTC GTGCCACACA AACTAATTTA TCCTGCATTA CTTTTTGACT 5340 CTTAAATGCC GCAGATTCTG GCAGCCAAAT ATCTAAGGCT AAATCCACCT TTTCTAGTTG 5400 TAGGTCCATC TGCAACTCTT CTTCAATGAG CGGCGGCTCA CGAAATACAA TATTAATTGC 5460 AGTGCCCTGT AACACTTGCT CAATTTGATC TTGCAAGAGT TGTATTGCCG ACTCGCTGGC 5520 ATACACATAA AAAGTTCGCT CACTTGAAGT GGGGTCAAAT GCTTCAAAGC TAGTCGCAAC 5580 TTGCTCAATT GTTGACATAG CGCCCGCGAG CTGTTGATAA AGCGTCATCG CACTTGCGGT 5640 AGGTTTAACT CCCCTACCCA CTCGAGTAAA CAACTCTTCT CCAACAATAC TTTTTAGCCT 5700 CGAAATCGCA TTACTAACCG ACGACTGAGT CAAATCCAGC TCTTCTGCCG CCCGGCTAAA 5760 AGATGAGGTG CGATACACCG CAGTAAAAAC GCGAAATAAA TTAAGATCAA AAGCTTTTTG 5820 CTGCGACATA AATCAGCTAT CTCCTTATCC TTATCCTTAT CCTTATAAAA AGTTAGCTCC 5880 AGAGCACTCT AGCTCAAAAA CAACTCAGCG TATTAAGCCA ATATTTTGGG AACTCAATTA 5940 ATATTCATAA TAAAAGTATT CATAATATAA ATACCAAGTC ATAATTTAGC CCTAATTATT 6000 AATCAATTCA AGTTACCTAT ACTGGCCTCA ATTAAGCAAA TGTCTCATCA GTCTCCCTGC 6060 AACTAAATGC AATATTGAGA CATAAAGCTT TGAACTGATT CAATCTTACG AGGGTAACTT 6120 ATGAAACAGA CTCTAATGGC TATCTCAATC ATGTCGCTTT TTTCATTCAA TGCGCTAGCA 6180 GCGCAACATG AACATGACCA CATCACTGTT GATTACGAAG GGAAAGCCGC AACAGAACAC 6240 ACCATAGCTC ACAACCAAGC TGTAGCTAAA ACACTTAACT TTGCCGACAC GCGTGCATTT 6300 GAGCAATCGT CTAAAAATCT AGTCGCCAAG TTTGATAAAG CAACTGCCGA TATATTACGT 6360 GCCGAATTTG CTTTTATTAG CGATGAAATC CCTGACTCGG TTAACCCGTC TCTCTACCGT 6420 CAGGCTCAGC TTAATATGGT GCCTAATGGT CTGTATAAAG TGAGCGATGG CATTTACCAG 6480 GTCCGCGGTA CCGACTTATC TAACCTTACA CTTATCCGCA GTGATAACGG TTGGATAGCA 6540 TACGATGTTT TGTTAACCAA AGAAGCAGCA AAAGCCTCAC TACAATTTGC GTTAAAGAAT 6600 CTACCTAAAG ATGGCGATTT ACCCGTTGTT GCGATGATTT ACTCCCATAG CCATGCGGAC 6660 CACTTTGGCG GAGCTCGCGG TGTTCAAGAG ATGTTCCCTG ATGTCAAAGT CTACGGCTCA 6720 GATAACATCA CTAAAGAAAT TGTCGATGAG AACGTACTTG CCGGTAACGC CATGAGCCGC 6780 CGCGCAGCTT ATCAATACGG CGCAACACTG GGCAAACATG ACCACGGTAT TGTTGATGCT 6840 GCGCTAGGTA AAGGTCTATC AAAAGGTGAA ATCACTTACG TCGCCCCAGA CTACACCTTA 6900 AACAGTGAAG GCAAATGGGA AACGCTGACG ATTGATGGTC TAGAGATGGT GTTTATGGAT 6960 GCCTCGGGCA CCGAAGCTGA GTCAGAAATG ATCACTTATA TTCCCTCTAA AAAAGCGCTC 7020 TGGACGGCGG AGCTTACCTA TCAAGGTATG CACAACATTT ATACGCTGCG CGGCGCTAAA 7080 GTACGTGATG CGCTCAAGTG GTCAAAAGAT ATCAACGAAA TGATCAATGC CTTTGGTCAA 7140 GATGTCGAAG TGCTGTTTGC CTCGCACTCT GCGCCAGTGT GGGGTAACCA AGCGATCAAC 7200 GATTTCTTAC GCCTACAGCG TGATAACTAC GGCCTAGTGC ACAATCAAAC CTTGAGACTT 7260 GCCAACGATG GTGTCGGTAT ACAAGATATT GGCGATGCGA TTCAAGACAC GATTCCAGAG 7320 TCTATCTACA AGACGTGGCA TACCAATGGT TACCACGGCA CTTATAGCCA TAACGCTAAA 7380 GCGGTTTATA ACAAGTATCT AGGCTACTTC GATATGAACC CAGCCAACCT TAATCCGCTG 7440 CCAACCAAGC AAGAATCTGC CAAGTTTGTC GAATACATGG GCGGCGCAGA TGCCGCAATT 7500 AAGCGCGCTA AAGATGATTA CGCTCAAGGT GAATACCGCT TTGTTGCAAC GGCATTAAAT 7560 AAGGTGGTGA TGGCCGAGCC AGAAAATGAC TCCGCTCGTC AATTGCTAGC CGATACCTAT 7620 GAGCAACTTG GTTATCAAGC AGAAGGGGCT GGCTGGAGAA ACATTTACTT AACTGGCGCA 7680 CAAGAGCTAC GAGTAGGTAT TCAAGCTGGC GCGCCTAAAA CCGCATCGGC AGATGTCATC 7740 AGTGAAATGG ACATGCCGAC TCTATTTGAC TTCCTCGCGG TGAAGATTGA TAGTCAACAG 7800 GCGGCTAAGC ACGGCTTAGT TAAGATGAAT GTTATCACCC CTGATACTAA AGATATTCTC 7860 TATATTGAGC TAAGCAACGG TAACTTAAGC AACGCAGTGG TCGACAAAGA GCAAGCAGCT 7920 GACGCAAACC TTATGGTTAA TAAAGCTGAC GTTAACCGCA TCTTACTTGG CCAAGTAACC 7980 CTAAAAGCGT TATTAGCCAG CGGCGATGCC AAGCTCACTG GTGATAAAAC GGCATTTAGT 8040 AAAATAGCCG ATAGCATGGT CGAGTTTACA CCTGACTTCG AAATCGTACC AACGCCTGTT 8100 AAATGAGGCA TTAATCTCAA CAAGTGCAAG CTAGACATAA AAATGGGGCG ATTAGACGCC 8160 CCATTTTTTA TGCAATTTTG AACTAGCTAG TCTTAGCTGA AGCTCGAACA ACAGCTTTAA 8220 AATTCACTTC TTCTGCTGCA ATACTTATTT GCTGACACTG ACCAATACTC AGTGCAAAAC 8280 GATAACTATC ATCAAGATGG CCCAGTAAAC AATGCCAATT ATCAGCAGCG TTCATTTGCT 8340 GTTCTTTAGC CTCAATCAAA CCTAAACCAG ACTTTTGTGG CTCAGCGTTA GGCTTATTAG 8400 AACTCGACTC TAGTAAAGCA AGACCAATAT CTTGTTTTAA CAAAACCTGT CGCTGATTAA 8460 GTTGATGCTC AACCTTGTGA TCCGCAATAG CATCGGAAAT ATCAACACAA TGGCTCAAGC 8520 TTTTAGGTGC ATTAACTCCA AGAAAAGTTT CGCTCAGTGC AGAGAAGTCA AACGCAAAAG 8580 ATTTTAGCGA TAATGCCAGC CCAAGTCCTT TCGCTTTAAT GTAAGACTCC TTGAGCGCCC 8640 ACAAATCAAA AAAGCGGTCT CGCTGCAAGG CCTCTGGTAA CGCTAACAAG GCTCGCTTTT 8700 CTGATTCAGA GAAATAATGA CTAAGAATAG AGTGGATATT GGTGCTGTTA CGGCAACGCT 8760 CAATGTCGAC GCCAAACTCA ATACTAGCAG AGTCAGTTTC CTCCTTGCTT GCCTGACTGG 8820 CGCCTTTATT ATCAGCAGTG CAAATGCCTA CTAATAGCCA ATCTCCACTA TGACTCACAT 8880 TAAAGTGGAC CCCGGTTTGA GCAAATTGCG CATCACTCAA TCTAGGCTTA CCTTTGTCGC 8940 CATATTCAAA GCGCCATTCA TTGGGGCGTA TTTCACTATG TTGTGACAAT AAAGCGCGCA 9000 AATAGCCTCT TACCATTAAA CCTTGAGTTT TAGCTTCTTG TTTAATGTAG CGATTAACCT 9060 TAATTAACTC ATCTTCAGGC AGCCATGACT TAACCAACTC TGTAGTCTGG TTATCGCACT 9120 CTTGTATTGT TAACGGACAG AAGTATAAGG AAATCAATCG AGAAGTTAGC AATTTTTCAG 9180 GACACTCTTT AAAGCAACAA ACATAACCCC TATTTTTACC AATTTAAGAT CAAAACTAAA 9240 GCCAAAACTA ATTGAGAATA GTGTCAAACT AGCTTTAAAG GAAAAAAATA TAAAAAGAAC 9300 ATTATACTTG TATAAATTAT TTTACACACC AAAGCCATGA TCTTCACAAA ATTAGCTCCC 9360 TCTCCCTAAA ACAAGATTGA ATAAAAAAAT AAACCTTAAC TTTCATATAG ATAAAACAAA 9420 CCAATGGGAT AAAGTATATT GAATTCATTT TTAAGGAAAA ATTCAAATTG AATTCAAGCT 9480 CTTCAGTAAA AGCATATTTT GCCGTTAGTG TGAAAAAAAA CAAATTTAAA AACCAACATA 9540 GAACAAATAA GCAGACAATA AAACCAAGGC GCAACACAAA CAACGCGCTT ACAATTTTCA 9600 CAAAAAAGCA ACAAGAGTAA CGTTTAGTAT TTGGATATGG TTATTGTAAT TGAGAATTTT 9660 ATAACAATTA TATTAAGGGA ATGAGTATGT TTTTAAATTC AAAACTTTCG CGCTCAGTCA 9720 AACTTGCCAT ATCCGCAGGC TTAACAGCCT CGCTAGCTAT GCCTGTTTTT GCAGAAGAAA 9780 CTGCTGCTGA AGAACAAATA GAAAGAGTCG CAGTGACCGG ATCGCGAATC GCTAAAGCAG 9840 AGCTAACTCA ACCAGCTCCA GTCGTCAGCC TTTCAGCCGA AGAACTGACA AAATTTGGTA 9900 ATCAAGATTT AGGTAGCGTA CTAGCAGAAT TACCTGCTAT TGGTGCAACC AACACTATTA 9960 TTGGTAATAA CAATAGCAAC TCAAGCGCAG GTGTTAGCTC AGCAGACTTG CGTCGTCTAG 10020 GTGCTAACAG AACCTTAGTA TTAGTCAACG GTAAGCGCTA CGTTGCCGGC CAACCGGGCT 10080 CAGCTGAGGT AGATTTGTCA ACTATACCAA CTAGCATGAT CTCGCGAGTT GAGATTGTAA 10140 CCGGCGGTGC TTCAGCAATT TATGGTTCGG ACGCTGTATC AGGTGTTATC AACGTTATCC 10200 TTAAAGAAGA CTTTGAAGGC TTTGAGTTTA ACGCACGTAC TAGCGGTTCT ACTGAAAGTG 10260 TAGGCACTCA AGAGCACTCT TTTGACATTT TGGGTGGTGC AAACGTTGCA GATGGACGTG 10320 GTAATGTAAC CTTCTACGCA GGTTATGAAC GTACAAAAGA AGTCATGGCT ACCGACATTC 10380 GCCAATTCGA TGCTTGGGGA ACAATTAAAA ACGAAGCCGA TGGTGGTGAA GATGATGGTA 10440 TTCCAGACAG ACTACGTGTA CCACGAGTTT ATTCTGAAAT GATTAATGCT ACCGGTGTTA 10500 TCAATGCATT TGGTGGTGGA ATTGGTCGCT CAACCTTTGA CAGTAACGGC AATCCTATTG 10560 CACAACAAGA ACGTGATGGG ACTAACAGCT TTGCATTTGG TTCATTCCCT AATGGCTGTG 10620 ACACATGTTT CAACACTGAA GCATACGAAA ACTATATTCC AGGGGTAGAA AGAATAAACG 10680 TTGGCTCATC ATTCAACTTT GATTTTACCG ATAACATTCA ATTTTACACT GACTTCAGAT 10740 ATGTAAAGTC AGATATTCAG CAACAATTTC AGCCTTCATT CCGTTTTGGT AACATTAATA 10800 TCAATGTTGA AGATAACGCC TTTTTGAATG ACGACTTGCG TCAGCAAATG CTCGATGCGG 10860 GTCAAACCAA TGCTAGTTTT GCCAAGTTTT TTGATGAATT AGGAAATCGC TCAGCAGAAA 10920 ATAAACGCGA ACTTTTCCGT TACGTAGGTG GCTTTAAAGG TGGCTTTGAT ATTAGCGAAA 10980 CCATATTTGA TTACGACCTT TACTATGTTT ATGGCGAGAC TAATAACCGT CGTAAAACCC 11040 TTAATGACCT AATTCCTGAT AACTTTGTCG CAGCTGTCGA CTCTGTTATT GATCCTGATA 11100 CTGGCTTAGC AGCGTGTCGC TCACAAGTAG CAAGCGCTCA AGGCGATGAC TATACAGATC 11160 CCGCGTCTGT AAATGGTAGC GACTGTGTTG CTTATAACCC ATTTGGCATG GGTCAAGCTT 11220 CAGCAGAAGC CCGCGACTGG GTTTCTGCTG ATGTGACTCG TGAAGACAAA ATAACTCAAC 11280 AAGTGATTGG TGGTACTCTC GGTACCGATT CTGAAGAACT ATTTGAGCTT CAAGGTGGTG 11340 CAATCGCTAT GGTTGTTGGT TTTGAATACC GTGAAGAAAC GTCTGGTTCA ACAACCGATG 11400 AATTTACTAA AGCAGGTTTC TTGACAAGCG CTGCAACGCC AGATTCTTAT GGCGAATACG 11460 ACGTGACTGA GTATTTTGTT GAGGTGAACA TCCCAGTACT AAAAGAATTA CCTTTTGCAC 11520 ATGAGTTGAG CTTTGACGGT GCATACCGTA ATGCTGATTA CTCACATGCC GGTAAGACTG 11580 AAGCATGGAA AGCTGGTATG TTCTACTCAC CATTAGAGCA ACTTGCATTA CGTGGTACGG 11640 TAGGTGAAGC AGTACGAGCA CCAAACATTG CAGAAGCCTT TAGTCCACGC TCTCCTGGTT 11700 TTGGCCGCGT TTCAGATCCA TGTGATGCAG ATAACATTAA TGACGATCCG GATCGCGTGT 11760 CAAACTGTGC AGCATTGGGG ATCCCTCCAG GATTCCAAGC TAATGATAAC GTCAGTGTAG 11820 ATACCTTATC TGGTGGTAAC CCAGATCTAA AACCTGAAAC ATCAACATCC TTTACAGGTG 11880 GTCTTGTTTG GACACCAACG TTTGCTGACA ATCTATCATT CACTGTCGAT TATTATGATA 11940 TTCAAATTGA GGATGCTATT TTGTCAGTAG CCACCCAGAC TGTGGCTGAT AACTGTGTTG 12000 ACTCAACTGG CGGACCTGAC ACCGACTTCT GTAGTCAAGT TGATCGTAAT CCAACGACCT 12060 ATGATATTGA ACTTGTTCGC TCTGGTTATC TAAATGCCGC GGCATTGAAT ACCAAAGGTA 12120 TTGAATTTCA AGCTGCATAC TCATTAGATC TAGAGTCTTT CAACGCGCCT GGTGAACTAC 12180 GCTTCAACCT ATTGGGGAAC CAATTACTTG AACTAGAACG TCTTGAATTC CAAAATCGTC 12240 CTGATGAGAT TAATGATGAA AAAGGCGAAG TAGGTGATCC AGAGCTGCAG TTCCGCCTAG 12300 GCATCGATTA CCGTCTAGAT GATCTAAGTG TTAGCTGGAA CACGCGTTAT ATTGATAGCG 12360 TAGTAACTTA TGATGTCTCT GAAAATGGTG GCTCTCCTGA AGATTTATAT CCAGGCCACA 12420 TAGGCTCAAT GACAACTCAT GACTTGAGCG CTACATACTA CATCAATGAG AACTTCATGA 12480 TTAACGGTGG TGTACGTAAC CTATTTGACG CACTTCCACC TGGATACACT AACGATGCGC 12540 TATATGATCT AGTTGGTCGC CGTGCATTCC TAGGTATTAA GGTAATGATG TAATTAATTA 12600 TTACGCCTCT AACTAATAAA AATGCAATCT CTTCGTAGAG ATTGCATTTT TTTATGAAAT 12660 CCAATCTTAA ACTGGTTCTC CGAGCATCTT ACGCCTTAAA AACCCCGCCC CTCAATGTAA 12720 CGCCAAAGTT AATTGCTTAC ACGCACTTAC ACAAACGAAC AATTTCATTA ACACGAGACA 12780 CAGCTCACGC TTTTTATTTT ACCCTTGATT TTACTACATA AAATTGCGTT TTAGCGCACA 12840 AGTGTTCTCC CAAGCTGGTC GTATCTGTAA TTATTCAGTC CCAGGTGATT GTATTGACCC 12900 ATAAGCTCAG GTAGTCTGCT CTGCCATTAG CTAAACAATA TTGACAAAAT GGCGATAAAA 12960 TGTGGCTTAG CGCTAAGTTC ACCGTAAGTT TTATCGGCAT TAAGTCCCAA CAGATTATTA 13020 ACGGAAACCC GCTAAACTGA TGGCAAAAAT AAATAGTGAA CACTTGGATG AAGCTACTAT 13080 TACTTCGAAT AAGTGTACGC AAACAGAGAC TGAGGCTCGG CATAGAAATG CCACTACAAC 13140 ACCTGAGATG CGCCGATTCA TACAAGAGTC GGATCTCAGT GTTAGCCAAC TGTCTAAAAT 13200 ATTAAATATC AGTGAAGCTA CCGTACGTAA GTGGCGCAAG CGTGACTCTG TCGAAAACTG 13260 TCCTAATACC CCGCACCATC TCAATACCAC GCTAACCCCT TTGCAAGAAT ATGTGGTTGT 13320 GGGCCTGCGT TATCAATTGA AAATGCCATT AGACAGATTG CTCAAAGCAA CCCAAGAGTT 13380 TATCAATCCA AACGTGTCGC GCTCAGGTTT AGCAAGATGT TTGAAGCGTT ATGGCGTTTC 13440 ACGGGTGAGT GATATCCAAA GCCCACACGT ACCAATGCGC TACTTTAATC AAATTCCAGT 13500 CACTCAAGGC AGCGATGTGC AAACCTACAC CCTGCACTAT GAAACGCTGG CAAAAACCTT 13560 AGCCTTACCT AGTACCGATG GTGACAATGT GGTGCAAGTG GTGTCTCTCA CCATTCCACC 13620 AAAGTTAACC GAAGAAGCAC CCAGTTCAAT TTTGCTCGGC ATTGATCCTC ATAGCGACTG 13680 GATCTATCTC GACATATACC AAGATGGCAA TACACAAGCC ACGAATAGAT ATATGGCTTA 13740 TGTGCTAAAA CACGGGCCAT TCCATTTACG AAAGTTACTC GTGCGTAACT ATCACACCTT 13800 TTTACAGCGC TTTCCTGGAG CGACGCAAAA TCGCCGCCCC TCTAAAGATA TGCCTGAAAC 13860 AATCAACAAG ACGCCTGAAA CACAGGCACC CAGTGGAGAC TCATAATGAG CCAGACCTCT 13920 AAACCTACAA ACTCAGCAAC TGAGCAAGCA CAAGACTCAC AAGCTGACTC TCGTTTAAAT 13980 AAACGACTAA AAGATATGCC AATTGCTATT GTTGGCATGG CGAGTATTTT TGCAAACTCT 14040 CGCTATTTGA ATAAGTTTTG GGACTTAATC AGCGAAAAAA TTGATGCGAT TACTGAATTA 14100 CCATCAACTC ACTGGCAGCC TGAAGAATAT TACGACGCAG ATAAAACCGC AGCAGACAAA 14160 AGCTACTGTA AACGTGGTGG CTTTTTGCCA GATGTAGACT TCAACCCAAT GGAGTTTGGC 14220 CTGCCGCCAA ACATTTTGGA ACTGACCGAT TCATCGCAAC TATTATCACT CATCGTTGCT 14280 AAAGAAGTGT TGGCTGATGC TAACTTACCT GAGAATTACG ACCGCGATAA AATTGGTATC 14340 ACCTTAGGTG TCGGCGGTGG TCAAAAAATT AGCCACAGCC TAACAGCGCG TCTGCAATAC 14400 CCAGTATTGA AGAAAGTATT CGCCAATAGC GGCATTAGTG ACACCGACAG CGAAATGCTT 14460 ATCAAGAAAT TCCAAGACCA ATATGTACAC TGGGAAGAAA ACTCGTTCCC AGGTTCACTT 14520 GGTAACGTTA TTGCGGGCCG TATCGCCAAC CGCTTCGATT TTGGCGGCAT GAACTGTGTG 14580 GTTGATGCTG CCTGTGCTGG ATCACTTGCT GCTATGCGTA TGGCGCTAAC AGAGCTAACT 14640 GAAGGTCGCT CTGAAATGAT GATCACCGGT GGTGTGTGTA CTGATAACTC ACCCTCTATG 14700 TATATGAGCT TTTCAAAAAC GCCCGCCTTT ACCACTAACG AAACCATTCA GCCATTTGAT 14760 ATCGACTCAA AAGGCATGAT GATTGGTGAA GGTATTGGCA TGGTGGCGCT AAAGCGTCTT 14820 GAAGATGCAG AGCGCGATGG CGACCGCATT TACTCTGTAA TTAAAGGTGT GGGTGCATCA 14880 TCTGACGGTA AGTTTAAATC AATCTATGCC CCTCGCCCAT CAGGCCAAGC TAAAGCACTT 14940 AACCGTGCCT ATGATGACGC AGGTTTTGCG CCGCATACCT TAGGTCTAAT TGAAGCTCAC 15000 GGAACAGGTA CTGCAGCAGG TGACGCGGCA GAGTTTGCCG GCCTTTGCTC AGTATTTGCT 15060 GAAGGCAACG ATACCAAGCA ACACATTGCG CTAGGTTCAG TTAAATCACA AATTGGTCAT 15120 ACTAAATCAA CTGCAGGTAC AGCAGGTTTA ATTAAAGCTG CTCTTGCTTT GCATCACAAG 15180 GTACTGCCGC CGACCATTAA CGTTAGTCAG CCAAGCCCTA AACTTGATAT CGAAAACTCA 15240 CCGTTTTATC TAAACACTGA GACTCGTCCA TGGTTACCAC GTGTTGATGG TACGCCGCGC 15300 CGCGCGGGTA TTAGCTCATT TGGTTTTGGT GGCACTAACT TCCATTTTGT ACTAGAAGAG 15360 TACAACCAAG AACACAGCCG TACTGATAGC GAAAAAGCTA AGTATCGTCA ACGCCAAGTG 15420 GCGCAAAGCT TCCTTGTTAG CGCAAGCGAT AAAGCATCGC TAATTAACGA GTTAAACGTA 15480 CTAGCAGCAT CTGCAAGCCA AGCTGAGTTT ATCCTCAAAG ATGCAGCAGC AAACTATGGC 15540 GTACGTGAGC TTGATAAAAA TGCACCACGG ATCGGTTTAG TTGCAAACAC AGCTGAAGAG 15600 TTAGCAGGCC TAATTAAGCA AGCACTTGCC AAACTAGCAG CTAGCGATGA TAACGCATGG 15660 CAGCTACCTG GTGGCACTAG CTACCGCGCC GCTGCAGTAG AAGGTAAAGT TGCCGCACTG 15720 TTTGCTGGCC AAGGTTCACA ATATCTCAAT ATGGGCCGTG ACCTTACTTG TTATTACCCA 15780 GAGATGCGTC AGCAATTTGT AACTGCAGAT AAAGTATTTG CCGCAAATGA TAAAACGCCG 15840 TTATCGCAAA CTCTGTATCC AAAGCCTGTA TTTAATAAAG ATGAATTAAA GGCTCAAGAA 15900 GCCATTTTGA CCAATACCGC CAATGCCCAA AGCGCAATTG GTGCGATTTC AATGGGTCAA 15960 TACGATTTGT TTACTGCGGC TGGCTTTAAT GCCGACATGG TTGCAGGCCA TAGCTTTGGT 16020 GAGCTAAGTG CACTGTGTGC TGCAGGTGTT ATTTCAGCTG ATGACTACTA CAAGCTGGCT 16080 TTTGCTCGTG GTGAGGCTAT GGCAACAAAA GCACCGGCTA AAGACGGCGT TGAAGCAGAT 16140 GCAGGAGCAA TGTTTGCAAT CATAACCAAG AGTGCTGCAG ACCTTGAAAC CGTTGAAGCC 16200 ACCATCGCTA AATTTGATGG GGTGAAAGTC GCTAACTATA ACGCGCCAAC GCAATCAGTA 16260 ATTGCAGGCC CAACAGCAAC TACCGCTGAT GCGGCTAAAG CGCTAACTGA GCTTGGTTAC 16320 AAAGCGATTA ACCTGCCAGT ATCAGGTGCA TTCCACACTG AACTTGTTGG TCACGCTCAA 16380 GCGCCATTTG CTAAAGCGAT TGACGCAGCC AAATTTACTA AAACAAGCCG AGCACTTTAC 16440 TCAAATGCAA CTGGCGGACT TTATGAAAGC ACTGCTGCAA AGATTAAAGC CTCGTTTAAG 16500 AAACATATGC TTCAATCAGT GCGCTTTACT AGCCAGCTAG AAGCCATGTA CAACGACGGC 16560 GCCCGTGTAT TTGTTGAATT TGGTCCAAAG AACATCTTAC AAAAATTAGT TCAAGGCACG 16620 CTTGTCAACA CTGAAAATGA AGTTTGCACT ATCTCTATCA ACCCTAATCC TAAAGTTGAT 16680 AGTGATCTGC AGCTTAAGCA AGCAGCAATG CAGCTAGCGG TTACTGGTGT GGTACTCAGT 16740 GAAATTGACC CATACCAAGC CGATATTGCC GCACCAGCGA AAAAGTCGCC AATGAGCATT 16800 TCGCTTAATG CTGCTAACCA TATCAGCAAA GCAACTCGCG CTAAGATGGC CAAGTCTTTA 16860 GAGACAGGTA TCGTCACCTC GCAAATAGAA CATGTTATTG AAGAAAAAAT CGTTGAAGTT 16920 GAGAAACTGG TTGAAGTCGA AAAGATCGTC GAAAAAGTGG TTGAAGTAGA GAAAGTTGTT 16980 GAGGTTGAAG CTCCTGTTAA TTCAGTGCAA GCCAATGCAA TTCAAACCCG TTCAGTTGTC 17040 GCTCCAGTAA TAGAGAACCA AGTCGTGTCT AAAAACAGTA AGCCAGCAGT CCAGAGCATT 17100 AGTGGTGATG CACTCAGCAA CTTTTTTGCT GCACAGCAGC AAACCGCACA GTTGCATCAG 17160 CAGTTCTTAG CTATTCCGCA GCAATATGGT GAGACGTTCA CTACGCTGAT GACCGAGCAA 17220 GCTAAACTGG CAAGTTCTGG TGTTGCAATT CCAGAGAGTC TGCAACGCTC AATGGAGCAA 17280 TTCCACCAAC TACAAGCGCA AACACTACAA AGCCACACCC AGTTCCTTGA GATGCAAGCG 17340 GGTAGCAACA TTGCAGCGTT AAACCTACTC AATAGCAGCC AAGCAACTTA CGCTCCAGCC 17400 ATTCACAATG AAGCGATTCA AAGCCAAGTG GTTCAAAGCC AAACTGCAGT CCAGCCAGTA 17460 ATTTCAACAC AAGTTAACCA TGTGTCAGAG CAGCCAACTC AAGCTCCAGC TCCAAAAGCG 17520 CAGCCAGCAC CTGTGACAAC TGCAGTTCAA ACTGCTCCGG CACAAGTTGT TCGTCAAGCC 17580 GCACCAGTTC AAGCCGCTAT TGAACCGATT AATACAAGTG TTGCGACTAC AACGCCTTCA 17640 GCCTTCAGCG CCGAAACAGC CCTGAGCGCA ACAAAAGTCC AAGCCACTAT GCTTGAAGTG 17700 GTTGCTGAGA AAACCGGTTA CCCAACTGAA ATGCTAGAGC TTGAAATGGA TATGGAAGCC 17760 GATTTAGGCA TCGATTCTAT CAAGCGTGTA GAAATTCTTG GCACAGTACA AGATGAGCTA 17820 CCGGGTCTAC CTGAGCTTAG CCCTGAAGAT CTAGCTGAGT GTCGAACGCT AGGCGAAATC 17880 GTTGACTATA TGGGCAGTAA ACTGCCGGCT GAAGGCTCTA TGAATTCTCA GCTGTCTACA 17940 GGTTCCGCAG CTGCGACTCC TGCAGCGAAT GGTCTTTCTG CGGAGAAAGT TCAAGCGACT 18000
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GATCTCTTAC AAAGAAACTA TCTCAATGTG AATTTAACCT TAATTCCGTT TAATTACGGC 60 CTGATAGAGC ATCACCCAAT CAGCCATAAA ACTGTAAAGT GGGTACTCAA AGGTGGCTGG 120 GCGATTCTTC TCAAATACAA AGTGCCCAAC CCAAGCAAAT CCATATCCGA TAACAGGTAA 180 AAGTAGCAAT AAACCCCAGC GCTGAGTTAG TAATACATAA GCGAATAATA GGATCACTAA 240 ACTACTGCCG AAATAGTGTA ATATTCGACA GTTTCTATGC TGATGTTGAG ATAAATAAAA 300 AGGGTAAAAT TCAGCAAAAG AACGATAGCG CTTACTCATT ACTCACACCT CGGTAAAAAA 360 GCAACTCGCC ATTAACTTGG CCAATCGTCA GTTGTTCTAT CGTCTCAAAG TTATGCCGAC 420 TAAATAACTC TATATGTGCA TTATGATTAG CAAAAACTCC GATACCATCA AGATGAAGTT 480 GTTCATCACA CCAACTCAAA ACTGCGTCGA TAAGCTTACT GCCATAGCCC TTGCCTTGCT 540 CCACATTTGC GATAGCAATA AACTGTAAAA TGCCACATTG GCCACTTGGT AAGCTCTCTA 600 TAATCTGATT TTCTTTGTTA ATAAGTGCCT GAGTTGAATA CCAACCAGTA CTTAACAACA 660 TCTTTAAACG CCAATGCCAA AAACGCGCTT CACCTAAGGG AACCTGCTGA GTCACTATGC 720 AGGCTACGCC TATCAATCTA TCCCCAACGA ACATACCAAT AAGTGCTTGC TCCTGTTGCC 780 AGAGCTCATT GAGTTCTTCT CGAATAGCCC CGCGAAGCTT TTGCTCATAC TGCGCTTGAT 840 CACCACTAAA AAGTGTTTCG ATAAAAAAGG GATCATCATG ATAGGCGTTA TAGAGAATAG 900 AGGCTGCTAT GCGTAAATCT TCTGCCGTGA GATAAACTGC ACGACACTCT TCCATGGCTT 960 GATCTTCCAT TGTTATTGTC CTTGACCTTG ATCACACAAC ACCAATGTAA CAAGACTGTA 1020 TAGAAGTGCA ATTAATAATC AATTCGTGCA TTAAGCAGGT CAGCATTTCT TTGCTAAACA 1080 AGCTTTATTG GCTTTGACAA AACTTTGCCT AGACTTTAAC GATAGAAATC ATAATGAAAG 1140 AGAAAAGCTA CAACCTAGAG GGGAATAATC AAACAACTGC TAAGATCTAG ATAATGTAAT 1200 AAACACCGAG TTTATCGACC ATACTTAGAT AGAGTCATAG CAACGAGAAT AGTTATGGAT 1260 ACAACGCCGC AAGATCTATC ACACCTGTTT TTACAGCTAG GATTAGCAAA TGATCAACCC 1320 GCAATTGAAC AGTTTATCAA TGACCATCAA TTAGCGGACA ATATATTGCT ACATCAAGCA 1380 AGCTTTTGGA GCCCATCGCA AAAGCACTTC TTAATTGAGT CATTTAATGA AGATGCCCAG 1440 TGGACCGAAG TCATCGACCA CTTAGACACC TTATTAAGAA AAAACTAACC ATTACAACAG 1500 CAACTTTAAA TTTTGCCGTA AGCCATCTCC CCCCACCCCA CAACAGCGTT GTTGCTTATG 1560 ACCACTGGAG TACATTCGTC TTTAGTCGTT TTACCATCAC CATGGGTACG TTGAGTGCGA 1620 TAAAAAAGCA CATAAACTTC TTTATCGGCC TGAATATAGG CTTCGTTAAA ATCAGCTGTT 1680 CCCATTAAAG TAACCACTTG CTCTTTACTC ATGCCTAGAG ATATCTTTGT CAAATTGTCA 1740 CGGTTTTTAT CTTGAGTTTT CTCCCAAGCA CCGTGATTAT CCCAGTCAGA TTCCCCATCA 1800 CCAACATTGA CCACACAGCC CGTTAGCCCT AAGCTTGCAA TCCCAAAACA TGCTAAACCT 1860 AATAATTTAT TTTTCATTTT AACTTCCTGT TATGACATTA TTTTTGCTTA GAAGAAAAGC 1920 AACTTACATG CCAAAACACA AGCTGTTGTT TTAAATGACT TTATTTATTA TTAGCCTTTT 1980 AGGATATGCC TAGAGCAATA ATAATTACCA ATGTTTAAGG AATTTGACTA ACTATGAGTC 2040 CGATTGAGCA AGTGCTAACA GCTGCTAAAA AAATCAATGA ACAAGGTAGA GAACCAACAT 2100 TAGCATTGAT TAAAACCAAA CTTGGTAATA GCATCCCAAT GCGCGAGTTA ATCCAAGGTT 2160 TGCAACAGTT TAAGTCTATG AGTGCAGAAG AAAGACAAGC AATACCTAGC AGCTTAGCAA 2220 CAGCAAAAGA AACTCAATAT GGTCAATCAA GCTTATCTCA ATCTGAACAA GCTGATAGGA 2280 TCCTCCAGCT AGAAAACGCC CTCAATGAAT TAAGAAACGA ATTTAATGGG CTAAAAAGTC 2340 AATTTGATAA CTTACAACAA AACCTGATGA ATAAAGAGCC TGACACCAAA TGCATGTAAT 2400 TGAACTACGA TTTGAATGTT TTGATAACAC CACGATTACT GCAGCAGAAA AAGCCATTAA 2460 TGGTTTGCTT GAAGCTTATC GAGCCAATGG CCAGGTTCTA GGTCGTGAAT TTGCCGTTGC 2520 ATTTAACGAT GGTGAGTTTA AAGCACGCAT GTTAACCCCA GAAAAAAGCA GCTTATCTAA 2580 ACGCTTTAAT AGTCCTTGGG TAAATAGTGC ACTCGAAGAG CTAACCGAAG CCAAATTGCT 2640 TGCGCCACGT GAAAAGTATA TTGGCCAAGA TATTAATTCT GAAGCATCTA GCCAAGACAC 2700 ACCAAGTTGG CAGCTACTTT ACACAAGTTA TGTGCACATG TGCTCACCAC TAAGAAATGG 2760 CGACACCTTG CAGCCTATTC CACTGTATCA AATTCCAGCA ACTGCCAACG GCGATCATAA 2820 ACGAATGATC CGTTGGCAAA CAGAATGGCA AGCTTGTGAT GAATTGCAAA TGGCCGCAGC 2880 TACTAAAGCT GAATTTGCCG CACTTGAAGA GCTAACCAGT CATCAGAGTG ATCTATTTAG 2940 GCGTGGTTGG GACTTACGTG GCAGAGTCGA ATACTTGACG AAAATTCCGA CCTATTACTA 3000 TTTATACCGT GTTGGCGGTG AAAGCTTAGC AGTAGAAAAG CAGCGCTCTT GTCCTAAGTG 3060 TGGCAGTCAA GAATGGCTGC TCGATAAACC ATTATTGGAT ATGTTCCATT TTCGCTGTGA 3120 CACCTGCCGC ATCGTATCTA ATATCTCTTG GGACCATTTA TAACTCTTCC GAGTCTTATC 3180 ACACTAGAGT TTAGTCAGCA TAAAAATGGC GCTTATATTT CAATTAAAAG AAATATAAGC 3240 GCCATTTTCA TCGATACTAT ATATCAGCAG ACTATTTTCC GCGTAAATTA GCCCACATTA 3300 ATTTCATTCT TTGCCAGATC CCTGGATGAT CTAGTTGTGG CATCGACTCT TCAATAGGTT 3360 TAACCGCAGG TGTAACCCTT GGAGTCAATT CGTTTATAAA CTCGTTTAAA CTGTCACTTA 3420 ATTTAACGCT TTGTACTTCA CCTGGAATTT CAATCCATAC GCTGCCATCA CTATTATTAA 3480 CCGTCAACAT TTTATCTTCA TCATCAAGAA TACCAATAAA CCAAGTCGGC TCTTGCTTAA 3540 GCTTTCTCTT CATCATTAAA TGACCAATGA TGTTTTGTTG TAAGTATTCA AAATCAGTTT 3600 GATCCCACAC TTGGATTAGC TCACCTTGGC CCCATTGTGA GTCAAAAAAT AGCGGTGCAG 3660 AAAAATGACT GCCAAAAAAT GGATTAATTT CTGCAGATAA TGTCATTTCA AGTGCTGTTT 3720 CAACATTAGC AAATTCACCA GGTTGTTGAC GTACAACCGA TTGCCAAAAC ACTGCGCCAT 3780 CGGAGCCCGC TTCGGCGACA ACACACTCAG ACTTTTGTCC TTGCGCATAA TATCTTGGCT 3840 GTTCACCAAG CTTATCCATG TAGGCTTGTT GATATTTAGA TAAAAAAAGA TCTAAAGCAG 3900 GTAAAGAAGA CACTTAAGCC AGTTCCAAAA TCAGTTATAA TAGGGGTCTA TTTTGACATG 3960 GAAACCGTAT TGATGACACA ACATCATGAT CCCTACAGTA ACGCCCCCGA ACTTTCTGAA 4020 TTAACTTTAG GAAAGTCGAC CGGTTATCAA GAGCAGTATG ATGCATCTTT ACTACAAGCG 4080 TGCCGCGTAA ATTAAACCGT GATGCTATCG GTCTAACCAA TGAGCTACCT TTTCATGGCT 4140 GTGATATTTG GACTGGCTAC GAACTGTCTT GGCTAAATGC TAAAGGCAAG CCAATGATTG 4200 CTATTGCAGA CTTTAACCTA AGTTTTGATA GTAAAAATCT GATCGAGTCT AAGTCGTTTA 4260 AGCTGTATTT AAACAGCTAT AACCAAACAC GATTTGATAG CGTTCAAGCG GTTCAAGAAC 4320 GTTTAACTGA AGACTTAAGC GCCTGTGCCC AAGGCACAGT TACGGTAAAA GTGATTGAAC 4380 CTAAGCAATT TAACCACCTG AGAGTGGTTG ATATGCCAGG TACCTGCATT GACGATTTAG 4440 ATATTGAAGT TGATGACTAT AGCTTTAACT CTGACTATCT CACCGACAGT GTTGATGACA 4500 AAGTCATGGT TGCTGAAACG CTAACGTCAA ACTTATTGAA ATCAAACTGC CTAATCACTT 4560 CTCAGCCTGA CTGGGGTACA GTGATGATCC GTTATCAAGG GCCTAAGATA GACCGTGAAA 4620 AGCTACTTAG ATATCTGATT TCATTTAGAC AGCACAATGA ATTTCATGAG CAGTGTGTTG 4680 AGCGTATATT TGTTGATTTA AAGCACTATT GCCAATGTGC CAAACTTACT GTCTATGCAC 4740 GTTATACCCG CCGTGGTGGT TTAGATATCA ACCCATATCG TAGCGACTTT GAAAACCCTG 4800 CAGAAAATCA GCGCCTAGCG AGACAGTAAT TGATTGCAGT ACCTACAAAA AACAATGCCT 4860 ATAAGCCAAG CTTATGGGCA TTTTTATATT ATCAACTTGT CATCAAACCT CAGCCGCCAA 4920 GCCTTTTAGT TTTATCGCTA AATTAAGCCG CTCTCTCAGC CAAATATTTG CAGGATTTTG 4980 CTGTAATTTA TGGCTCCACA CCATGAAATA CTCTATCGGC TCTACCGCAA AAGGTAAGTC 5040 AAATACCTGT AAGCCAAACA GCTTGGCATA TTCGTCAGTG TGGGCTTTTG ACGCGATAGC 5100 TAACGCATCA CTTTTTGAGG CAACCGACAT CATACTTAAT ATTGATGATT GCTCGCTGTG 5160 CATTTGCCTT GCCGGTAACA CCTGTTTAGT CAGCAAGTCG GCAACACTTA AATTGTAGCG 5220 GCGCATCTTA AAAATAATAT GCTTTTCATT AAAGTATTGC TCTTGCGTCA ACCCACCTTG 5280 GATCCTTGGG TGAGCATTTC GTGCCACACA AACTAATTTA TCCTGCATTA CTTTTTGACT 5340 CTTAAATGCC GCAGATTCTG GCAGCCAAAT ATCTAAGGCT AAATCCACCT TTTCTAGTTG 5400 TAGGTCCATC TGCAACTCTT CTTCAATGAG CGGCGGCTCA CGAAATACAA TATTAATTGC 5460 AGTGCCCTGT AACACTTGCT CAATTTGATC TTGCAAGAGT TGTATTGCCG ACTCGCTGGC 5520 ATACACATAA AAAGTTCGCT CACTTGAAGT GGGGTCAAAT GCTTCAAAGC TAGTCGCAAC 5580 TTGCTCAATT GTTGACATAG CGCCCGCGAG CTGTTGATAA AGCGTCATCG CACTTGCGGT 5640 AGGTTTAACT CCCCTACCCA CTCGAGTAAA CAACTCTTCT CCAACAATAC TTTTTAGCCT 5700 CGAAATCGCA TTACTAACCG ACGACTGAGT CAAATCCAGC TCTTCTGCCG CCCGGCTAAA 5760 AGATGAGGTG CGATACACCG CAGTAAAAAC GCGAAATAAA TTAAGATCAA AAGCTTTTTG 5820 CTGCGACATA AATCAGCTAT CTCCTTATCC TTATCCTTAT CCTTATAAAA AGTTAGCTCC 5880 AGAGCACTCT AGCTCAAAAA CAACTCAGCG TATTAAGCCA ATATTTTGGG AACTCAATTA 5940 ATATTCATAA TAAAAGTATT CATAATATAA ATACCAAGTC ATAATTTAGC CCTAATTATT 6000 AATCAATTCA AGTTACCTAT ACTGGCCTCA ATTAAGCAAA TGTCTCATCA GTCTCCCTGC 6060 AACTAAATGC AATATTGAGA CATAAAGCTT TGAACTGATT CAATCTTACG AGGGTAACTT 6120 ATGAAACAGA CTCTAATGGC TATCTCAATC ATGTCGCTTT TTTCATTCAA TGCGCTAGCA 6180 GCGCAACATG AACATGACCA CATCACTGTT GATTACGAAG GGAAAGCCGC AACAGAACAC 6240 ACCATAGCTC ACAACCAAGC TGTAGCTAAA ACACTTAACT TTGCCGACAC GCGTGCATTT 6300 GAGCAATCGT CTAAAAATCT AGTCGCCAAG TTTGATAAAG CAACTGCCGA TATATTACGT 6360 GCCGAATTTG CTTTTATTAG CGATGAAATC CCTGACTCGG TTAACCCGTC TCTCTACCGT 6420 CAGGCTCAGC TTAATATGGT GCCTAATGGT CTGTATAAAG TGAGCGATGG CATTTACCAG 6480 GTCCGCGGTA CCGACTTATC TAACCTTACA CTTATCCGCA GTGATAACGG TTGGATAGCA 6540 TACGATGTTT TGTTAACCAA AGAAGCAGCA AAAGCCTCAC TACAATTTGC GTTAAAGAAT 6600 CTACCTAAAG ATGGCGATTT ACCCGTTGTT GCGATGATTT ACTCCCATAG CCATGCGGAC 6660 CACTTTGGCG GAGCTCGCGG TGTTCAAGAG ATGTTCCCTG ATGTCAAAGT CTACGGCTCA 6720 GATAACATCA CTAAAGAAAT TGTCGATGAG AACGTACTTG CCGGTAACGC CATGAGCCGC 6780 CGCGCAGCTT ATCAATACGG CGCAACACTG GGCAAACATG ACCACGGTAT TGTTGATGCT 6840 GCGCTAGGTA AAGGTCTATC AAAAGGTGAA ATCACTTACG TCGCCCCAGA CTACACCTTA 6900 AACAGTGAAG GCAAATGGGA AACGCTGACG ATTGATGGTC TAGAGATGGT GTTTATGGAT 6960 GCCTCGGGCA CCGAAGCTGA GTCAGAAATG ATCACTTATA TTCCCTCTAA AAAAGCGCTC 7020 TGGACGGCGG AGCTTACCTA TCAAGGTATG CACAACATTT ATACGCTGCG CGGCGCTAAA 7080 GTACGTGATG CGCTCAAGTG GTCAAAAGAT ATCAACGAAA TGATCAATGC CTTTGGTCAA 7140 GATGTCGAAG TGCTGTTTGC CTCGCACTCT GCGCCAGTGT GGGGTAACCA AGCGATCAAC 7200 GATTTCTTAC GCCTACAGCG TGATAACTAC GGCCTAGTGC ACAATCAAAC CTTGAGACTT 7260 GCCAACGATG GTGTCGGTAT ACAAGATATT GGCGATGCGA TTCAAGACAC GATTCCAGAG 7320 TCTATCTACA AGACGTGGCA TACCAATGGT TACCACGGCA CTTATAGCCA TAACGCTAAA 7380 GCGGTTTATA ACAAGTATCT AGGCTACTTC GATATGAACC CAGCCAACCT TAATCCGCTG 7440 CCAACCAAGC AAGAATCTGC CAAGTTTGTC GAATACATGG GCGGCGCAGA TGCCGCAATT 7500 AAGCGCGCTA AAGATGATTA CGCTCAAGGT GAATACCGCT TTGTTGCAAC GGCATTAAAT 7560 AAGGTGGTGA TGGCCGAGCC AGAAAATGAC TCCGCTCGTC AATTGCTAGC CGATACCTAT 7620 GAGCAACTTG GTTATCAAGC AGAAGGGGCT GGCTGGAGAA ACATTTACTT AACTGGCGCA 7680 CAAGAGCTAC GAGTAGGTAT TCAAGCTGGC GCGCCTAAAA CCGCATCGGC AGATGTCATC 7740 AGTGAAATGG ACATGCCGAC TCTATTTGAC TTCCTCGCGG TGAAGATTGA TAGTCAACAG 7800 GCGGCTAAGC ACGGCTTAGT TAAGATGAAT GTTATCACCC CTGATACTAA AGATATTCTC 7860 TATATTGAGC TAAGCAACGG TAACTTAAGC AACGCAGTGG TCGACAAAGA GCAAGCAGCT 7920 GACGCAAACC TTATGGTTAA TAAAGCTGAC GTTAACCGCA TCTTACTTGG CCAAGTAACC 7980 CTAAAAGCGT TATTAGCCAG CGGCGATGCC AAGCTCACTG GTGATAAAAC GGCATTTAGT 8040 AAAATAGCCG ATAGCATGGT CGAGTTTACA CCTGACTTCG AAATCGTACC AACGCCTGTT 8100 AAATGAGGCA TTAATCTCAA CAAGTGCAAG CTAGACATAA AAATGGGGCG ATTAGACGCC 8160 CCATTTTTTA TGCAATTTTG AACTAGCTAG TCTTAGCTGA AGCTCGAACA ACAGCTTTAA 8220 AATTCACTTC TTCTGCTGCA ATACTTATTT GCTGACACTG ACCAATACTC AGTGCAAAAC 8280 GATAACTATC ATCAAGATGG CCCAGTAAAC AATGCCAATT ATCAGCAGCG TTCATTTGCT 8340 GTTCTTTAGC CTCAATCAAA CCTAAACCAG ACTTTTGTGG CTCAGCGTTA GGCTTATTAG 8400 AACTCGACTC TAGTAAAGCA AGACCAATAT CTTGTTTTAA CAAAACCTGT CGCTGATTAA 8460 GTTGATGCTC AACCTTGTGA TCCGCAATAG CATCGGAAAT ATCAACACAA TGGCTCAAGC 8520 TTTTAGGTGC ATTAACTCCA AGAAAAGTTT CGCTCAGTGC AGAGAAGTCA AACGCAAAAG 8580 ATTTTAGCGA TAATGCCAGC CCAAGTCCTT TCGCTTTAAT GTAAGACTCC TTGAGCGCCC 8640 ACAAATCAAA AAAGCGGTCT CGCTGCAAGG CCTCTGGTAA CGCTAACAAG GCTCGCTTTT 8700 CTGATTCAGA GAAATAATGA CTAAGAATAG AGTGGATATT GGTGCTGTTA CGGCAACGCT 8760 CAATGTCGAC GCCAAACTCA ATACTAGCAG AGTCAGTTTC CTCCTTGCTT GCCTGACTGG 8820 CGCCTTTATT ATCAGCAGTG CAAATGCCTA CTAATAGCCA ATCTCCACTA TGACTCACAT 8880 TAAAGTGGAC CCCGGTTTGA GCAAATTGCG CATCACTCAA TCTAGGCTTA CCTTTGTCGC 8940 CATATTCAAA GCGCCATTCA TTGGGGCGTA TTTCACTATG TTGTGACAAT AAAGCGCGCA 9000 AATAGCCTCT TACCATTAAA CCTTGAGTTT TAGCTTCTTG TTTAATGTAG CGATTAACCT 9060 TAATTAACTC ATCTTCAGGC AGCCATGACT TAACCAACTC TGTAGTCTGG TTATCGCACT 9120 CTTGTATTGT TAACGGACAG AAGTATAAGG AAATCAATCG AGAAGTTAGC AATTTTTCAG 9180 GACACTCTTT AAAGCAACAA ACATAACCCC TATTTTTACC AATTTAAGAT CAAAACTAAA 9240 GCCAAAACTA ATTGAGAATA GTGTCAAACT AGCTTTAAAG GAAAAAAATA TAAAAAGAAC 9300 ATTATACTTG TATAAATTAT TTTACACACC AAAGCCATGA TCTTCACAAA ATTAGCTCCC 9360 TCTCCCTAAA ACAAGATTGA ATAAAAAAAT AAACCTTAAC TTTCATATAG ATAAAACAAA 9420 CCAATGGGAT AAAGTATATT GAATTCATTT TTAAGGAAAA ATTCAAATTG AATTCAAGCT 9480 CTTCAGTAAA AGCATATTTT GCCGTTAGTG TGAAAAAAAA CAAATTTAAA AACCAACATA 9540 GAACAAATAA GCAGACAATA AAACCAAGGC GCAACACAAA CAACGCGCTT ACAATTTTCA 9600 CAAAAAAGCA ACAAGAGTAA CGTTTAGTAT TTGGATATGG TTATTGTAAT TGAGAATTTT 9660 ATAACAATTA TATTAAGGGA ATGAGTATGT TTTTAAATTC AAAACTTTCG CGCTCAGTCA 9720 AACTTGCCAT ATCCGCAGGC TTAACAGCCT CGCTAGCTAT GCCTGTTTTT GCAGAAGAAA 9780 CTGCTGCTGA AGAACAAATA GAAAGAGTCG CAGTGACCGG ATCGCGAATC GCTAAAGCAG 9840 AGCTAACTCA ACCAGCTCCA GTCGTCAGCC TTTCAGCCGA AGAACTGACA AAATTTGGTA 9900 ATCAAGATTT AGGTAGCGTA CTAGCAGAAT TACCTGCTAT TGGTGCAACC AACACTATTA 9960 TTGGTAATAA CAATAGCAAC TCAAGCGCAG GTGTTAGCTC AGCAGACTTG CGTCGTCTAG 10020 GTGCTAACAG AACCTTAGTA TTAGTCAACG GTAAGCGCTA CGTTGCCGGC CAACCGGGCT 10080 CAGCTGAGGT AGATTTGTCA ACTATACCAA CTAGCATGAT CTCGCGAGTT GAGATTGTAA 10140 CCGGCGGTGC TTCAGCAATT TATGGTTCGG ACGCTGTATC AGGTGTTATC AACGTTATCC 10200 TTAAAGAAGA CTTTGAAGGC TTTGAGTTTA ACGCACGTAC TAGCGGTTCT ACTGAAAGTG 10260 TAGGCACTCA AGAGCACTCT TTTGACATTT TGGGTGGTGC AAACGTTGCA GATGGACGTG 10320 GTAATGTAAC CTTCTACGCA GGTTATGAAC GTACAAAAGA AGTCATGGCT ACCGACATTC 10380 GCCAATTCGA TGCTTGGGGA ACAATTAAAA ACGAAGCCGA TGGTGGTGAA GATGATGGTA 10440 TTCCAGACAG ACTACGTGTA CCACGAGTTT ATTCTGAAAT GATTAATGCT ACCGGTGTTA 10500 TCAATGCATT TGGTGGTGGA ATTGGTCGCT CAACCTTTGA CAGTAACGGC AATCCTATTG 10560 CACAACAAGA ACGTGATGGG ACTAACAGCT TTGCATTTGG TTCATTCCCT AATGGCTGTG 10620 ACACATGTTT CAACACTGAA GCATACGAAA ACTATATTCC AGGGGTAGAA AGAATAAACG 10680 TTGGCTCATC ATTCAACTTT GATTTTACCG ATAACATTCA ATTTTACACT GACTTCAGAT 10740 ATGTAAAGTC AGATATTCAG CAACAATTTC AGCCTTCATT CCGTTTTGGT AACATTAATA 10800 TCAATGTTGA AGATAACGCC TTTTTGAATG ACGACTTGCG TCAGCAAATG CTCGATGCGG 10860 GTCAAACCAA TGCTAGTTTT GCCAAGTTTT TTGATGAATT AGGAAATCGC TCAGCAGAAA 10920 ATAAACGCGA ACTTTTCCGT TACGTAGGTG GCTTTAAAGG TGGCTTTGAT ATTAGCGAAA 10980 CCATATTTGA TTACGACCTT TACTATGTTT ATGGCGAGAC TAATAACCGT CGTAAAACCC 11040 TTAATGACCT AATTCCTGAT AACTTTGTCG CAGCTGTCGA CTCTGTTATT GATCCTGATA 11100 CTGGCTTAGC AGCGTGTCGC TCACAAGTAG CAAGCGCTCA AGGCGATGAC TATACAGATC 11160 CCGCGTCTGT AAATGGTAGC GACTGTGTTG CTTATAACCC ATTTGGCATG GGTCAAGCTT 11220 CAGCAGAAGC CCGCGACTGG GTTTCTGCTG ATGTGACTCG TGAAGACAAA ATAACTCAAC 11280 AAGTGATTGG TGGTACTCTC GGTACCGATT CTGAAGAACT ATTTGAGCTT CAAGGTGGTG 11340 CAATCGCTAT GGTTGTTGGT TTTGAATACC GTGAAGAAAC GTCTGGTTCA ACAACCGATG 11400 AATTTACTAA AGCAGGTTTC TTGACAAGCG CTGCAACGCC AGATTCTTAT GGCGAATACG 11460 ACGTGACTGA GTATTTTGTT GAGGTGAACA TCCCAGTACT AAAAGAATTA CCTTTTGCAC 11520 ATGAGTTGAG CTTTGACGGT GCATACCGTA ATGCTGATTA CTCACATGCC GGTAAGACTG 11580 AAGCATGGAA AGCTGGTATG TTCTACTCAC CATTAGAGCA ACTTGCATTA CGTGGTACGG 11640 TAGGTGAAGC AGTACGAGCA CCAAACATTG CAGAAGCCTT TAGTCCACGC TCTCCTGGTT 11700 TTGGCCGCGT TTCAGATCCA TGTGATGCAG ATAACATTAA TGACGATCCG GATCGCGTGT 11760 CAAACTGTGC AGCATTGGGG ATCCCTCCAG GATTCCAAGC TAATGATAAC GTCAGTGTAG 11820 ATACCTTATC TGGTGGTAAC CCAGATCTAA AACCTGAAAC ATCAACATCC TTTACAGGTG 11880 GTCTTGTTTG GACACCAACG TTTGCTGACA ATCTATCATT CACTGTCGAT TATTATGATA 11940 TTCAAATTGA GGATGCTATT TTGTCAGTAG CCACCCAGAC TGTGGCTGAT AACTGTGTTG 12000 ACTCAACTGG CGGACCTGAC ACCGACTTCT GTAGTCAAGT TGATCGTAAT CCAACGACCT 12060 ATGATATTGA ACTTGTTCGC TCTGGTTATC TAAATGCCGC GGCATTGAAT ACCAAAGGTA 12120 TTGAATTTCA AGCTGCATAC TCATTAGATC TAGAGTCTTT CAACGCGCCT GGTGAACTAC 12180 GCTTCAACCT ATTGGGGAAC CAATTACTTG AACTAGAACG TCTTGAATTC CAAAATCGTC 12240 CTGATGAGAT TAATGATGAA AAAGGCGAAG TAGGTGATCC AGAGCTGCAG TTCCGCCTAG 12300 GCATCGATTA CCGTCTAGAT GATCTAAGTG TTAGCTGGAA CACGCGTTAT ATTGATAGCG 12360 TAGTAACTTA TGATGTCTCT GAAAATGGTG GCTCTCCTGA AGATTTATAT CCAGGCCACA 12420 TAGGCTCAAT GACAACTCAT GACTTGAGCG CTACATACTA CATCAATGAG AACTTCATGA 12480 TTAACGGTGG TGTACGTAAC CTATTTGACG CACTTCCACC TGGATACACT AACGATGCGC 12540 TATATGATCT AGTTGGTCGC CGTGCATTCC TAGGTATTAA GGTAATGATG TAATTAATTA 12600 TTACGCCTCT AACTAATAAA AATGCAATCT CTTCGTAGAG ATTGCATTTT TTTATGAAAT 12660 CCAATCTTAA ACTGGTTCTC CGAGCATCTT ACGCCTTAAA AACCCCGCCC CTCAATGTAA 12720 CGCCAAAGTT AATTGCTTAC ACGCACTTAC ACAAACGAAC AATTTCATTA ACACGAGACA 12780 CAGCTCACGC TTTTTATTTT ACCCTTGATT TTACTACATA AAATTGCGTT TTAGCGCACA 12840 AGTGTTCTCC CAAGCTGGTC GTATCTGTAA TTATTCAGTC CCAGGTGATT GTATTGACCC 12900 ATAAGCTCAG GTAGTCTGCT CTGCCATTAG CTAAACAATA TTGACAAAAT GGCGATAAAA 12960 TGTGGCTTAG CGCTAAGTTC ACCGTAAGTT TTATCGGCAT TAAGTCCCAA CAGATTATTA 13020 ACGGAAACCC GCTAAACTGA TGGCAAAAAT AAATAGTGAA CACTTGGATG AAGCTACTAT 13080 TACTTCGAAT AAGTGTACGC AAACAGAGAC TGAGGCTCGG CATAGAAATG CCACTACAAC 13140 ACCTGAGATG CGCCGATTCA TACAAGAGTC GGATCTCAGT GTTAGCCAAC TGTCTAAAAT 13200 ATTAAATATC AGTGAAGCTA CCGTACGTAA GTGGCGCAAG CGTGACTCTG TCGAAAACTG 13260 TCCTAATACC CCGCACCATC TCAATACCAC GCTAACCCCT TTGCAAGAAT ATGTGGTTGT 13320 GGGCCTGCGT TATCAATTGA AAATGCCATT AGACAGATTG CTCAAAGCAA CCCAAGAGTT 13380 TATCAATCCA AACGTGTCGC GCTCAGGTTT AGCAAGATGT TTGAAGCGTT ATGGCGTTTC 13440 ACGGGTGAGT GATATCCAAA GCCCACACGT ACCAATGCGC TACTTTAATC AAATTCCAGT 13500 CACTCAAGGC AGCGATGTGC AAACCTACAC CCTGCACTAT GAAACGCTGG CAAAAACCTT 13560 AGCCTTACCT AGTACCGATG GTGACAATGT GGTGCAAGTG GTGTCTCTCA CCATTCCACC 13620 AAAGTTAACC GAAGAAGCAC CCAGTTCAAT TTTGCTCGGC ATTGATCCTC ATAGCGACTG 13680 GATCTATCTC GACATATACC AAGATGGCAA TACACAAGCC ACGAATAGAT ATATGGCTTA 13740 TGTGCTAAAA CACGGGCCAT TCCATTTACG AAAGTTACTC GTGCGTAACT ATCACACCTT 13800 TTTACAGCGC TTTCCTGGAG CGACGCAAAA TCGCCGCCCC TCTAAAGATA TGCCTGAAAC 13860 AATCAACAAG ACGCCTGAAA CACAGGCACC CAGTGGAGAC TCATAATGAG CCAGACCTCT 13920 AAACCTACAA ACTCAGCAAC TGAGCAAGCA CAAGACTCAC AAGCTGACTC TCGTTTAAAT 13980 AAACGACTAA AAGATATGCC AATTGCTATT GTTGGCATGG CGAGTATTTT TGCAAACTCT 14040 CGCTATTTGA ATAAGTTTTG GGACTTAATC AGCGAAAAAA TTGATGCGAT TACTGAATTA 14100 CCATCAACTC ACTGGCAGCC TGAAGAATAT TACGACGCAG ATAAAACCGC AGCAGACAAA 14160 AGCTACTGTA AACGTGGTGG CTTTTTGCCA GATGTAGACT TCAACCCAAT GGAGTTTGGC 14220 CTGCCGCCAA ACATTTTGGA ACTGACCGAT TCATCGCAAC TATTATCACT CATCGTTGCT 14280 AAAGAAGTGT TGGCTGATGC TAACTTACCT GAGAATTACG ACCGCGATAA AATTGGTATC 14340 ACCTTAGGTG TCGGCGGTGG TCAAAAAATT AGCCACAGCC TAACAGCGCG TCTGCAATAC 14400 CCAGTATTGA AGAAAGTATT CGCCAATAGC GGCATTAGTG ACACCGACAG CGAAATGCTT 14460 ATCAAGAAAT TCCAAGACCA ATATGTACAC TGGGAAGAAA ACTCGTTCCC AGGTTCACTT 14520 GGTAACGTTA TTGCGGGCCG TATCGCCAAC CGCTTCGATT TTGGCGGCAT GAACTGTGTG 14580 GTTGATGCTG CCTGTGCTGG ATCACTTGCT GCTATGCGTA TGGCGCTAAC AGAGCTAACT 14640 GAAGGTCGCT CTGAAATGAT GATCACCGGT GGTGTGTGTA CTGATAACTC ACCCTCTATG 14700 TATATGAGCT TTTCAAAAAC GCCCGCCTTT ACCACTAACG AAACCATTCA GCCATTTGAT 14760 ATCGACTCAA AAGGCATGAT GATTGGTGAA GGTATTGGCA TGGTGGCGCT AAAGCGTCTT 14820 GAAGATGCAG AGCGCGATGG CGACCGCATT TACTCTGTAA TTAAAGGTGT GGGTGCATCA 14880 TCTGACGGTA AGTTTAAATC AATCTATGCC CCTCGCCCAT CAGGCCAAGC TAAAGCACTT 14940 AACCGTGCCT ATGATGACGC AGGTTTTGCG CCGCATACCT TAGGTCTAAT TGAAGCTCAC 15000 GGAACAGGTA CTGCAGCAGG TGACGCGGCA GAGTTTGCCG GCCTTTGCTC AGTATTTGCT 15060 GAAGGCAACG ATACCAAGCA ACACATTGCG CTAGGTTCAG TTAAATCACA AATTGGTCAT 15120 ACTAAATCAA CTGCAGGTAC AGCAGGTTTA ATTAAAGCTG CTCTTGCTTT GCATCACAAG 15180 GTACTGCCGC CGACCATTAA CGTTAGTCAG CCAAGCCCTA AACTTGATAT CGAAAACTCA 15240 CCGTTTTATC TAAACACTGA GACTCGTCCA TGGTTACCAC GTGTTGATGG TACGCCGCGC 15300 CGCGCGGGTA TTAGCTCATT TGGTTTTGGT GGCACTAACT TCCATTTTGT ACTAGAAGAG 15360 TACAACCAAG AACACAGCCG TACTGATAGC GAAAAAGCTA AGTATCGTCA ACGCCAAGTG 15420 GCGCAAAGCT TCCTTGTTAG CGCAAGCGAT AAAGCATCGC TAATTAACGA GTTAAACGTA 15480 CTAGCAGCAT CTGCAAGCCA AGCTGAGTTT ATCCTCAAAG ATGCAGCAGC AAACTATGGC 15540 GTACGTGAGC TTGATAAAAA TGCACCACGG ATCGGTTTAG TTGCAAACAC AGCTGAAGAG 15600 TTAGCAGGCC TAATTAAGCA AGCACTTGCC AAACTAGCAG CTAGCGATGA TAACGCATGG 15660 CAGCTACCTG GTGGCACTAG CTACCGCGCC GCTGCAGTAG AAGGTAAAGT TGCCGCACTG 15720 TTTGCTGGCC AAGGTTCACA ATATCTCAAT ATGGGCCGTG ACCTTACTTG TTATTACCCA 15780 GAGATGCGTC AGCAATTTGT AACTGCAGAT AAAGTATTTG CCGCAAATGA TAAAACGCCG 15840 TTATCGCAAA CTCTGTATCC AAAGCCTGTA TTTAATAAAG ATGAATTAAA GGCTCAAGAA 15900 GCCATTTTGA CCAATACCGC CAATGCCCAA AGCGCAATTG GTGCGATTTC AATGGGTCAA 15960 TACGATTTGT TTACTGCGGC TGGCTTTAAT GCCGACATGG TTGCAGGCCA TAGCTTTGGT 16020 GAGCTAAGTG CACTGTGTGC TGCAGGTGTT ATTTCAGCTG ATGACTACTA CAAGCTGGCT 16080 TTTGCTCGTG GTGAGGCTAT GGCAACAAAA GCACCGGCTA AAGACGGCGT TGAAGCAGAT 16140 GCAGGAGCAA TGTTTGCAAT CATAACCAAG AGTGCTGCAG ACCTTGAAAC CGTTGAAGCC 16200 ACCATCGCTA AATTTGATGG GGTGAAAGTC GCTAACTATA ACGCGCCAAC GCAATCAGTA 16260 ATTGCAGGCC CAACAGCAAC TACCGCTGAT GCGGCTAAAG CGCTAACTGA GCTTGGTTAC 16320 AAAGCGATTA ACCTGCCAGT ATCAGGTGCA TTCCACACTG AACTTGTTGG TCACGCTCAA 16380 GCGCCATTTG CTAAAGCGAT TGACGCAGCC AAATTTACTA AAACAAGCCG AGCACTTTAC 16440 TCAAATGCAA CTGGCGGACT TTATGAAAGC ACTGCTGCAA AGATTAAAGC CTCGTTTAAG 16500 AAACATATGC TTCAATCAGT GCGCTTTACT AGCCAGCTAG AAGCCATGTA CAACGACGGC 16560 GCCCGTGTAT TTGTTGAATT TGGTCCAAAG AACATCTTAC AAAAATTAGT TCAAGGCACG 16620 CTTGTCAACA CTGAAAATGA AGTTTGCACT ATCTCTATCA ACCCTAATCC TAAAGTTGAT 16680 AGTGATCTGC AGCTTAAGCA AGCAGCAATG CAGCTAGCGG TTACTGGTGT GGTACTCAGT 16740 GAAATTGACC CATACCAAGC CGATATTGCC GCACCAGCGA AAAAGTCGCC AATGAGCATT 16800 TCGCTTAATG CTGCTAACCA TATCAGCAAA GCAACTCGCG CTAAGATGGC CAAGTCTTTA 16860 GAGACAGGTA TCGTCACCTC GCAAATAGAA CATGTTATTG AAGAAAAAAT CGTTGAAGTT 16920 GAGAAACTGG TTGAAGTCGA AAAGATCGTC GAAAAAGTGG TTGAAGTAGA GAAAGTTGTT 16980 GAGGTTGAAG CTCCTGTTAA TTCAGTGCAA GCCAATGCAA TTCAAACCCG TTCAGTTGTC 17040 GCTCCAGTAA TAGAGAACCA AGTCGTGTCT AAAAACAGTA AGCCAGCAGT CCAGAGCATT 17100 AGTGGTGATG CACTCAGCAA CTTTTTTGCT GCACAGCAGC AAACCGCACA GTTGCATCAG 17160 CAGTTCTTAG CTATTCCGCA GCAATATGGT GAGACGTTCA CTACGCTGAT GACCGAGCAA 17220 GCTAAACTGG CAAGTTCTGG TGTTGCAATT CCAGAGAGTC TGCAACGCTC AATGGAGCAA 17280 TTCCACCAAC TACAAGCGCA AACACTACAA AGCCACACCC AGTTCCTTGA GATGCAAGCG 17340 GGTAGCAACA TTGCAGCGTT AAACCTACTC AATAGCAGCC AAGCAACTTA CGCTCCAGCC 17400 ATTCACAATG AAGCGATTCA AAGCCAAGTG GTTCAAAGCC AAACTGCAGT CCAGCCAGTA 17460 ATTTCAACAC AAGTTAACCA TGTGTCAGAG CAGCCAACTC AAGCTCCAGC TCCAAAAGCG 17520 CAGCCAGCAC CTGTGACAAC TGCAGTTCAA ACTGCTCCGG CACAAGTTGT TCGTCAAGCC 17580 GCACCAGTTC AAGCCGCTAT TGAACCGATT AATACAAGTG TTGCGACTAC AACGCCTTCA 17640 GCCTTCAGCG CCGAAACAGC CCTGAGCGCA ACAAAAGTCC AAGCCACTAT GCTTGAAGTG 17700 GTTGCTGAGA AAACCGGTTA CCCAACTGAA ATGCTAGAGC TTGAAATGGA TATGGAAGCC 17760 GATTTAGGCA TCGATTCTAT CAAGCGTGTA GAAATTCTTG GCACAGTACA AGATGAGCTA 17820 CCGGGTCTAC CTGAGCTTAG CCCTGAAGAT CTAGCTGAGT GTCGAACGCT AGGCGAAATC 17880 GTTGACTATA TGGGCAGTAA ACTGCCGGCT GAAGGCTCTA TGAATTCTCA GCTGTCTACA 17940 GGTTCCGCAG CTGCGACTCC TGCAGCGAAT GGTCTTTCTG CGGAGAAAGT TCAAGCGACT 18000
【００４８】 ATGATGTCTG TGGTTGCCGA AAAGACTGGC TACCCAACTG AAATGCTAGA GCTTGAAATG 18060 GATATGGAAG CCGATTTAGG CATAGATTCT ATCAAGCGCG TTGAAATTCT TGGCACAGTA 18120 CAAGATGAGC TACCGGGTCT ACCTGAGCTT AGCCCTGAAG ATCTAGCTGA GTGTCGTACT 18180 CTAGGCGAAA TCGTTGACTA TATGAACTCT AAACTCGCTG ACGGCTCTAA GCTGCCGGCT 18240 GAAGGCTCTA TGAATTCTCA GCTGTCTACA AGTGCCGCAG CTGCGACTCC TGCAGCGAAT 18300 GGTCTCTCTG CGGAGAAAGT TCAAGCGACT ATGATGTCTG TGGTTGCCGA AAAGACTGGC 18360 TACCCAACTG AAATGCTAGA ACTTGAAATG GATATGGAAG CTGACCTTGG CATCGATTCA 18420 ATCAAGCGCG TTGAAATTCT TGGCACAGTA CAAGATGAGC TACCGGGTTT ACCTGAGCTA 18480 AATCCAGAAG ATTTGGCAGA GTGTCGTACT CTTGGCGAAA TCGTGACTTA TATGAACTCT 18540 AAACTCGCTG ACGGCTCTAA GCTGCCAGCT GAAGGCTCTA TGCACTATCA GCTGTCTACA 18600 AGTACCGCTG CTGCGACTCC TGTAGCGAAT GGTCTCTCTG CAGAAAAAGT TCAAGCGACC 18660 ATGATGTCTG TAGTTGCAGA TAAAACTGGC TACCCAACTG AAATGCTTGA ACTTGAAATG 18720 GATATGGAAG CCGATTTAGG TATCGATTCT ATCAAGCGCG TTGAAATTCT TGGCACAGTA 18780 CAAGATGAGC TACCGGGTTT ACCTGAGCTA AATCCAGAAG ATCTAGCAGA GTGTCGCACC 18840 CTAGGCGAAA TCGTTGACTA TATGGGCAGT AAACTGCCGG CTGAAGGCTC TGCTAATACA 18900 AGTGCCGCTG CGTCTCTTAA TGTTAGTGCC GTTGCGGCGC CTCAAGCTGC TGCGACTCCT 18960 GTATCGAACG GTCTCTCTGC AGAGAAAGTG CAAAGCACTA TGATGTCAGT AGTTGCAGAA 19020 AAGACCGGCT ACCCAACTGA AATGCTAGAA CTTGGCATGG ATATGGAAGC CGATTTAGGT 19080 ATCGACTCAA TTAAACGCGT TGAGATTCTT GGCACAGTAC AAGATGAGCT ACCGGGTCTA 19140 CCAGAGCTTA ATCCTGAAGA TTTAGCTGAG TGCCGTACGC TGGGCGAAAT CGTTGACTAT 19200 ATGAACTCTA AGCTGGCTGA CGGCTCTAAG CTTCCAGCTG AAGGCTCTGC TAATACAAGT 19260 GCCACTGCTG CGACTCCTGC AGTGAATGGT CTTTCTGCTG ACAAGGTACA GGCGACTATG 19320 ATGTCTGTAG TTGCTGAAAA GACCGGCTAC CCAACTGAAA TGCTAGAACT TGGCATGGAT 19380 ATGGAAGCAG ACCTTGGTAT TGATTCTATT AAGCGCGTTG AAATTCTTGG CACAGTACAA 19440 GATGAGCTCC CAGGTTTACC TGAGCTTAAT CCTGAAGATC TCGCTGAGTG CCGCACGCTT 19500 GGCGAAATCG TTAGCTATAT GAACTCTCAA CTGGCTGATG GCTCTAAACT TTCTACAAGT 19560 GCGGCTGAAG GCTCTGCTGA TACAAGTGCT GCAAATGCTG CAAAGCCGGC AGCAATTTCG 19620 GCAGAACCAA GTGTTGAGCT TCCTCCTCAT AGCGAGGTAG CGCTAAAAAA GCTTAATGCG 19680 GCGAACAAGC TAGAAAATTG TTTCGCCGCA GACGCAAGTG TTGTGATTAA CGATGATGGT 19740 CACAACGCAG GCGTTTTAGC TGAGAAACTT ATTAAACAAG GCCTAAAAGT AGCCGTTGTG 19800 CGTTTACCGA AAGGTCAGCC TCAATCGCCA CTTTCAAGCG ATGTTGCTAG CTTTGAGCTT 19860 GCCTCAAGCC AAGAATCTGA GCTTGAAGCC AGTATCACTG CAGTTATCGC GCAGATTGAA 19920 ACTCAGGTTG GCGCTATTGG TGGCTTTATT CACTTGCAAC CAGAAGCGAA TACAGAAGAG 19980 CAAACGGCAG TAAACCTAGA TGCGCAAAGT TTTACTCACG TTAGCAATGC GTTCTTGTGG 20040 GCCAAATTAT TGCAACCAAA GCTCGTTGCT GGAGCAGATG CGCGTCGCTG TTTTGTAACA 20100 GTAAGCCGTA TCGACGGTGG CTTTGGTTAC CTAAATACTG ACGCCCTAAA AGATGCTGAG 20160 CTAAACCAAG CAGCATTAGC TGGTTTAACT AAAACCTTAA GCCATGAATG GCCACAAGTG 20220 TTCTGTCGCG CGCTAGATAT TGCAACAGAT GTTGATGCAA CCCATCTTGC TGATGCAATC 20280 ACCAGTGAAC TATTTGATAG CCAAGCTCAG CTACCTGAAG TGGGCTTAAG CTTAATTGAT 20340 GGCAAAGTTA ACCGCGTAAC TCTAGTTGCT GCTGAAGCTG CAGATAAAAC AGCAAAAGCA 20400 GAGCTTAACA GCACAGATAA AATCTTAGTG ACTGGTGGGG CAAAAGGGGT GACATTTGAA 20460 TGTGCACTGG CATTAGCATC TCGCAGCCAG TCTCACTTTA TCTTAGCTGG GCGCAGTGAA 20520 TTACAAGCTT TACCAAGCTG GGCTGAGGGT AAGCAAACTA GCGAGCTAAA ATCAGCTGCA 20580 ATCGCACATA TTATTTCTAC TGGTCAAAAG CCAACGCCTA AGCAAGTTGA AGCCGCTGTG 20640 TGGCCAGTGC AAAGCAGCAT TGAAATTAAT GCCGCCCTAG CCGCCTTTAA CAAAGTTGGC 20700 GCCTCAGCTG AATACGTCAG CATGGATGTT ACCGATAGCG CCGCAATCAC AGCAGCACTT 20760 AATGGTCGCT CAAATGAGAT CACCGGTCTT ATTCATGGCG CAGGTGTACT AGCCGACAAG 20820 CATATTCAAG ACAAGACTCT TGCTGAACTT GCTAAAGTTT ATGGCACTAA AGTCAACGGC 20880 CTAAAAGCGC TGCTCGCGGC ACTTGAGCCA AGCAAAATTA AATTACTTGC TATGTTCTCA 20940 TCTGCAGCAG GTTTTTACGG TAATATCGGC CAAAGCGATT ACGCGATGTC GAACGATATT 21000 CTTAACAAGG CAGCGCTGCA GTTCACCGCT CGCAACCCAC AAGCTAAAGT CATGAGCTTT 21060 AACTGGGGTC CTTGGGATGG CGGCATGGTT AACCCAGCGC TTAAAAAGAT GTTTACCGAG 21120 CGTGGTGTGT ACGTTATTCC ACTAAAAGCA GGTGCAGAGC TATTTGCCAC TCAGCTATTG 21180 GCTGAAACTG GCGTGCAGTT GCTCATTGGT ACGTCAATGC AAGGTGGCAG CGACACTAAA 21240 GCAACTGAGA CTGCTTCTGT AAAAAAGCTT AATGCGGGTG AGGTGCTAAG TGCATCGCAT 21300 CCGCGTGCTG GTGCACAAAA AACACCACTA CAAGCTGTCA CTGCAACGCG TCTGTTAACC 21360 CCAAGTGCCA TGGTCTTCAT TGAAGATCAC CGCATTGGCG GTAACAGTGT GTTGCCAACG 21420 GTATGCGCCA TCGACTGGAT GCGTGAAGCG GCAAGCGACA TGCTTGGCGC TCAAGTTAAG 21480 GTACTTGATT ACAAGCTATT AAAAGGCATT GTATTTGAGA CTGATGAGCC GCAAGAGTTA 21540 ACACTTGAGC TAACGCCAGA CGATTCAGAC GAAGCTACGC TACAAGCATT AATCAGCTGT 21600 AATGGGCGTC CGCAATACAA GGCGACGCTT ATCAGTGATA ATGCCGATAT TAAGCAACTT 21660 AACAAGCAGT TTGATTTAAG CGCTAAGGCG ATTACCACAG CAAAAGAGCT TTATAGCAAC 21720 GGCACCTTGT TCCACGGTCC GCGTCTACAA GGGATCCAAT CTGTAGTGCA GTTCGATGAT 21780 CAAGGCTTAA TTGCTAAAGT CGCTCTGCCT AAGGTTGAAC TTAGCGATTG TGGTGAGTTC 21840 TTGCCGCAAA CCCACATGGG TGGCAGTCAA CCTTTTGCTG AGGACTTGCT ATTACAAGCT 21900 ATGCTGGTTT GGGCTCGCCT TAAAACTGGC TCGGCAAGTT TGCCATCAAG CATTGGTGAG 21960 TTTACCTCAT ACCAACCAAT GGCCTTTGGT GAAACTGGTA CCATAGAGCT TGAAGTGATT 22020 AAGCACAACA AACGCTCACT TGAAGCGAAT GTTGCGCTAT ATCGTGACAA CGGCGAGTTA 22080 AGTGCCATGT TTAAGTCAGC TAAAATCACC ATTAGCAAAA GCTTAAATTC AGCATTTTTA 22140 CCTGCTGTCT TAGCAAACGA CAGTGAGGCG AATTAGTGGA ACAAACGCCT AAAGCTAGTG 22200 CGATGCCGCT GCGCATCGCA CTTATCTTAC TGCCAACACC GCAGTTTGAA GTTAACTCTG 22260 TCGACCAGTC AGTATTAGCC AGCTATCAAA CACTGCAGCC TGAGCTAAAT GCCCTGCTTA 22320 ATAGTGCGCC GACACCTGAA ATGCTCAGCA TCACTATCTC AGATGATAGC GATGCAAACA 22380 GCTTTGAGTC GCAGCTAAAT GCTGCGACCA ACGCAATTAA CAATGGCTAT ATCGTCAAGC 22440 TTGCTACGGC AACTCACGCT TTGTTAATGC TGCCTGCATT AAAAGCGGCG CAAATGCGGA 22500 TCCATCCTCA TGCGCAGCTT GCCGCTATGC AGCAAGCTAA ATCGACGCCA ATGAGTCAAG 22560 TATCTGGTGA GCTAAAGCTT GGCGCTAATG CGCTAAGCCT AGCTCAGACT AATGCGCTGT 22620 CTCATGCTTT AAGCCAAGCC AAGCGTAACT TAACTGATGT CAGCGTGAAT GAGTGTTTTG 22680 AGAACCTCAA AAGTGAACAG CAGTTCACAG AGGTTTATTC GCTTATTCAG CAACTTGCTA 22740 GCCGCACCCA TGTGAGAAAA GAGGTTAATC AAGGTGTGGA ACTTGGCCCT AAACAAGCCA 22800 AAAGCCACTA TTGGTTTAGC GAATTTCACC AAAACCGTGT TGCTGCCATC AACTTTATTA 22860 ATGGCCAACA AGCAACCAGC TATGTGCTTA CTCAAGGTTC AGGATTGTTA GCTGCGAAAT 22920 CAATGCTAAA CCAGCAAAGA TTAATGTTTA TCTTGCCGGG TAACAGTCAG CAACAAATAA 22980 CCGCATCAAT AACTCAGTTA ATGCAGCAAT TAGAGCGTTT GCAGGTAACT GAGGTTAATG 23040 AGCTTTCTCT AGAATGCCAA CTAGAGCTGC TCAGCATAAT GTATGACAAC TTAGTCAACG 23100 CAGACAAACT CACTACTCGC GATAGTAAGC CCGCTTATCA GGCTGTGATT CAAGCAAGCT 23160 CTGTTAGCGC TGCAAAGCAA GAGTTAAGCG CGCTTAACGA TGCACTCACA GCGCTGTTTG 23220 CTGAGCAAAC AAACGCCACA TCAACGAATA AAGGCTTAAT CCAATACAAA ACACCGGCGG 23280 GCAGTTACTT AACCCTAACA CCGCTTGGCA GCAACAATGA CAACGCCCAA GCGGGTCTTG 23340 CTTTTGTCTA TCCGGGTGTG GGAACGGTTT ACGCCGATAT GCTTAATGAG CTGCATCAGT 23400 ACTTCCCTGC GCTTTACGCC AAACTTGAGC GTGAAGGCGA TTTAAAGGCG ATGCTACAAG 23460 CAGAAGATAT CTATCATCTT GACCCTAAAC ATGCTGCCCA AATGAGCTTA GGTGACTTAG 23520 CCATTGCTGG CGTGGGGAGC AGCTACCTGT TAACTCAGCT GCTCACCGAT GAGTTTAATA 23580 TTAAGCCTAA TTTTGCATTA GGTTACTCAA TGGGTGAAGC ATCAATGTGG GCAAGCTTAG 23640 GCGTATGGCA AAACCCGCAT GCGCTGATCA GCAAAACCCA AACCGACCCG CTATTTACTT 23700 CTGCTATTTC CGGCAAATTG ACCGCGGTTA GACAAGCTTG GCAGCTTGAT GATACCGCAG 23760 CGGAAATCCA GTGGAATAGC TTTGTGGTTA GAAGTGAAGC AGCGCCGATT GAAGCCTTGC 23820 TAAAAGATTA CCCACACGCT TACCTCGCGA TTATTCAAGG GGATACCTGC GTAATCGCTG 23880 GCTGTGAAAT CCAATGTAAA GCGCTACTTG CAGCACTGGG TAAACGCGGT ATTGCAGCTA 23940 ATCGTGTAAC GGCGATGCAT ACGCAGCCTG CGATGCAAGA GCATCAAAAT GTGATGGATT 24000 TTTATCTGCA ACCGTTAAAA GCAGAGCTTC CTAGTGAAAT AAGCTTTATC AGCGCCGCTG 24060 ATTTAACTGC CAAGCAAACG GTGAGTGAGC AAGCACTTAG CAGCCAAGTC GTTGCTCAGT 24120 CTATTGCCGA CACCTTCTGC CAAACCTTGG ACTTTACCGC GCTAGTACAT CACGCCCAAC 24180 ATCAAGGCGC TAAGCTGTTT GTTGAAATTG GCGCGGATAG ACAAAACTGC ACCTTGATAG 24240 ACAAGATTGT TAAACAAGAT GGTGCCAGCA GTGTACAACA TCAACCTTGT TGCACAGTGC 24300 CTATGAACGC AAAAGGTAGC CAAGATATTA CCAGCGTGAT TAAAGCGCTT GGCCAATTAA 24360 TTAGCCATCA GGTGCCATTA TCGGTGCAAC CATTTATTGA TGGACTCAAG CGCGAGCTAA 24420 CACTTTGCCA ATTGACCAGC CAACAGCTGG CAGCACATGC AAATGTTGAC AGCAAGTTTG 24480 AGTCTAACCA AGACCATTTA CTTCAAGGGG AAGTCTAATG TCATTACCAG ACAATGCTTC 24540 TAACCACCTT TCTGCCAACC AGAAAGGCGC ATCTCAGGCA AGTAAAACCA GTAAGCAAAG 24600 CAAAATCGCC ATTGTCGGTT TAGCCACTCT GTATCCAGAC GCTAAAACCC CGCAAGAATT 24660 TTGGCAGAAT TTGCTGGATA AACGCGACTC TCGCAGCACC TTAACTAACG AAAAACTCGG 24720 CGCTAACAGC CAAGATTATC AAGGTGTGCA AGGCCAATCT GACCGTTTTT ATTGTAATAA 24780 AGGCGGCTAC ATTGAGAACT TCAGCTTTAA TGCTGCAGGC TACAAATTGC CGGAGCAAAG 24840 CTTAAATGGC TTGGACGACA GCTTCCTTTG GGCGCTCGAT ACTAGCCGTA ACGCACTAAT 24900 TGATGCTGGT ATTGATATCA ACGGCGCTGA TTTAAGCCGC GCAGGTGTAG TCATGGGCGC 24960 GCTGTCGTTC CCAACTACCC GCTCAAACGA TCTGTTTTTG CCAATTTATC ACAGCGCCGT 25020 TGAAAAAGCC CTGCAAGATA AACTAGGCGT AAAGGCATTT AAGCTAAGCC CAACTAATGC 25080 TCATACCGCT CGCGCGGCAA ATGAGAGCAG CCTAAATGCA GCCAATGGTG CCATTGCCCA 25140 TAACAGCTCA AAAGTGGTGG CCGATGCACT TGGCCTTGGC GGCGCACAAC TAAGCCTAGA 25200 TGCTGCCTGT GCTAGTTCGG TTTACTCATT AAAGCTTGCC TGCGATTACC TAAGCACTGG 25260 CAAAGCCGAT ATCATGCTAG CAGGCGCAGT ATCTGGCGCG GATCCTTTCT TTATTAATAT 25320 GGGATTCTCA ATCTTCCACG CCTACCCAGA CCATGGTATC TCAGTACCGT TTGATGCCAG 25380 CAGTAAAGGT TTGTTTGCTG GCGAAGGCGC TGGCGTATTA GTGCTTAAAC GTCTTGAAGA 25440 TGCCGAGCGC GACAATGACA AAATCTATGC GGTTGTTAGC GGCGTAGGTC TATCAAACGA 25500 CGGTAAAGGC CAGTTTGTAT TAAGCCCTAA TCCAAAAGGT CAGGTGAAGG CCTTTGAACG 25560 TGCTTATGCT GCCAGTGACA TTGAGCCAAA AGACATTGAA GTGATTGAGT GCCACGCAAC 25620 AGGCACACCG CTTGGCGATA AAATTGAGCT CACTTCAATG GAAACCTTCT TTGAAGACAA 25680 GCTGCAAGGC ACCGATGCAC CGTTAATTGG CTCAGCTAAG TCTAACTTAG GCCACCTATT 25740 AACTGCAGCG CATGCGGGGA TCATGAAGAT GATCTTCGCC ATGAAAGAAG GTTACCTGCC 25800 GCCAAGTATC AATATTAGTG ATGCTATCGC TTCGCCGAAA AAACTCTTCG GTAAACCAAC 25860 CCTGCCTAGC ATGGTTCAAG GCTGGCCAGA TAAGCCATCG AATAATCATT TTGGTGTAAG 25920 AACCCGTCAC GCAGGCGTAT CGGTATTTGG CTTTGGTGGC TGTAACGCCC ATCTGTTGCT 25980 TGAGTCATAC AACGGCAAAG GAACAGTAAA GGCAGAAGCC ACTCAAGTAC CGCGTCAAGC 26040 TGAGCCGCTA AAAGTGGTTG GCCTTGCCTC GCACTTTGGG CCTCTTAGCA GCATTAATGC 26100 ACTCAACAAT GCTGTGACCC AAGATGGGAA TGGCTTTATC GAACTGCCGA AAAAGCGCTG 26160 GAAAGGCCTT GAAAAGCACA GTGAACTGTT AGCTGAATTT GGCTTAGCAT CTGCGCCAAA 26220 AGGTGCTTAT GTTGATAACT TCGAGCTGGA CTTTTTACGC TTTAAACTGC CGCCAAACGA 26280 AGATGACCGT TTGATCTCAC AGCAGCTAAT GCTAATGCGA GTAACAGACG AAGCCATTCG 26340 TGATGCCAAG CTTGAGCCGG GGCAAAAAGT AGCTGTATTA GTGGCAATGG AAACTGAGCT 26400 TGAACTGCAT CAGTTCCGCG GCCGGGTTAA CTTGCATACT CAATTAGCGC AAAGTCTTGC 26460 CGCCATGGGC GTGAGTTTAT CAACGGATGA ATACCAAGCG CTTGAAGCCA TCGCCATGGA 26520 CAGCGTGCTT GATGCTGCCA AGCTCAATCA GTACACCAGC TTTATTGGTA ATATTATGGC 26580 GTCACGCGTG GCGTCACTAT GGGACTTTAA TGGCCCAGCC TTCACTATTT CAGCAGCAGA 26640 GCAATCTGTG AGCCGCTGTA TCGATGTGGC GCAAAACCTC ATCATGGAGG ATAACCTAGA 26700 TGCGGTGGTG ATTGCAGCGG TCGATCTCTC TGGTAGCTTT GAGCAAGTCA TTCTTAAAAA 26760 TGCCATTGCA CCTGTAGCCA TTGAGCCAAA CCTCGAAGCA AGCCTTAATC CAACATCAGC 26820 AAGCTGGAAT GTCGGTGAAG GTGCTGGCGC GGTCGTGCTT GTTAAAAATG AAGCTACATC 26880 GGGCTGCTCA TACGGCCAAA TTGATGCACT TGGCTTTGCT AAAACTGCCG AAACAGCGTT 26940 GGCTACCGAC AAGCTACTGA GCCAAACTGC CACAGACTTT AATAAGGTTA AAGTGATTGA 27000 AACTATGGCA GCGCCTGCTA GCCAAATTCA ATTAGCGCCA ATAGTTAGCT CTCAAGTGAC 27060 TCACACTGCT GCAGAGCAGC GTGTTGGTCA CTGCTTTGCT GCAGCGGGTA TGGCAAGCCT 27120 ATTACACGGC TTACTTAACT TAAATACTGT AGCCCAAACC AATAAAGCCA ATTGCGCGCT 27180 TATCAACAAT ATCAGTGAAA ACCAATTATC ACAGCTGTTG ATTAGCCAAA CAGCGAGCGA 27240 ACAACAAGCA TTAACCGCGC GTTTAAGCAA TGAGCTTAAA TCCGATGCTA AACACCAACT 27300 GGTTAAGCAA GTCACCTTAG GTGGCCGTGA TATCTACCAG CATATTGTTG ATACACCGCT 27360 TGCAAGCCTT GAAAGCATTA CTCAGAAATT GGCGCAAGCG ACAGCATCGA CAGTGGTCAA 27420 CCAAGTTAAA CCTATTAAGG CCGCTGGCTC AGTCGAAATG GCTAACTCAT TCGAAACGGA 27480 AAGCTCAGCA GAGCCACAAA TAACAATTGC AGCACAACAG ACTGCAAACA TTGGCGTCAC 27540 CGCTCAGGCA ACCAAACGTG AATTAGGTAC CCCACCAATG ACAACAAATA CCATTGCTAA 27600 TACAGCAAAT AATTTAGACA AGACTCTTGA GACTGTTGCT GGCAATACTG TTGCTAGCAA 27660 GGTTGGCTCT GGCGACATAG TCAATTTTCA ACAGAACCAA CAATTGGCTC AACAAGCTCA 27720 CCTCGCCTTT CTTGAAAGCC GCAGTGCGGG TATGAAGGTG GCTGATGCTT TATTGAAGCA 27780 ACAGCTAGCT CAAGTAACAG GCCAAACTAT CGATAATCAG GCCCTCGATA CTCAAGCCGT 27840 CGATACTCAA ACAAGCGAGA ATGTAGCGAT TGCCGCAGAA TCACCAGTTC AAGTTACAAC 27900 ACCTGTTCAA GTTACAACAC CTGTTCAAAT CAGTGTTGTG GAGTTAAAAC CAGATCACGC 27960 TAATGTGCCA CCATACACGC CGCCAGTGCC TGCATTAAAG CCGTGTATCT GGAACTATGC 28020 CGATTTAGTT GAGTACGCAG AAGGCGATAT CGCCAAGGTA TTTGGCAGTG ATTATGCCAT 28080 TATCGACAGC TACTCGCGCC GCGTACGTCT ACCGACCACT GACTACCTGT TGGTATCGCG 28140 CGTGACCAAA CTTGATGCGA CCATCAATCA ATTTAAGCCA TGCTCAATGA CCACTGAGTA 28200 CGACATCCCT GTTGATGCGC CGTACTTAGT AGACGGACAA ATCCCTTGGG CGGTAGCAGT 28260 AGAATCAGGC CAATGTGACT TGATGCTTAT TAGCTATCTC GGTATCGACT TTGAGAACAA 28320 AGGCGAGCGG GTTTATCGAC TACTCGATTG TACCCTCACC TTCCTAGGCG ACTTGCCACG 28380 TGGCGGAGAT ACCCTACGTT ACGACATTAA GATCAATAAC TATGCTCGCA ACGGCGACAC 28440 CCTGCTGTTC TTCTTCTCGT ATGAGTGTTT TGTTGGCGAC AAGATGATCC TCAAGATGGA 28500 TGGCGGCTGC GCTGGCTTCT TCACTGATGA AGAGCTTGCC GACGGTAAAG GCGTGATTCG 28560 CACAGAAGAA GAGATTAAAG CTCGCAGCCT AGTGCAAAAG CAACGCTTTA ATCCGTTACT 28620 AGATTGTCCT AAAACCCAAT TTAGTTATGG TGATATTCAT AAGCTATTAA CTGCTGATAT 28680 TGAGGGTTGT TTTGGCCCAA GCCACAGTGG CGTCCACCAG CCGTCACTTT GTTTCGCATC 28740 TGAAAAATTC TTGATGATTG AACAAGTCAG CAAGGTTGAT CGCACTGGCG GTACTTGGGG 28800 ACTTGGCTTA ATTGAGGGTC ATAAGCAGCT TGAAGCAGAC CACTGGTACT TCCCATGTCA 28860 TTTCAAGGGC GACCAAGTGA TGGCTGGCTC GCTAATGGCT GAAGGTTGTG GCCAGTTATT 28920 GCAGTTCTAT ATGCTGCACC TTGGTATGCA TACCCAAACT AAAAATGGTC GTTTCCAACC 28980 TCTTGAAAAC GCCTCACAGC AAGTACGCTG TCGCGGTCAA GTGCTGCCAC AATCAGGCGT 29040 GCTAACTTAC CGTATGGAAG TGACTGAAAT CGGTTTCAGT CCACGCCCAT ATGCTAAAGC 29100 TAACATCGAT ATCTTGCTTA ATGGCAAAGC GGTAGTGGAT TTCCAAAACC TAGGGGTGAT 29160 GATAAAAGAG GAAGATGAGT GTACTCGTTA TCCACTTTTG ACTGAATCAA CAACGGCTAG 29220 CACTGCACAA GTAAACGCTC AAACAAGTGC GAAAAAGGTA TACAAGCCAG CATCAGTCAA 29280 TGCGCCATTA ATGGCACAAA TTCCTGATCT GACTAAAGAG CCAAACAAGG GCGTTATTCC 29340 GATTTCCCAT GTTGAAGCAC CAATTACGCC AGACTACCCG AACCGTGTAC CTGATACAGT 29400 GCCATTCACG CCGTATCACA TGTTTGAGTT TGCTACAGGC AATATCGAAA ACTGTTTCGG 29460 GCCAGAGTTC TCAATCTATC GCGGCATGAT CCCACCACGT ACACCATGCG GTGACTTACA 29520 AGTGACCACA CGTGTGATTG AAGTTAACGG TAAGCGTGGC GACTTTAAAA AGCCATCATC 29580 GTGTATCGCT GAATATGAAG TGCCTGCAGA TGCGTGGTAT TTCGATAAAA ACAGCCACGG 29640 CGCAGTGATG CCATATTCAA TTTTAATGGA GATCTCACTG CAACCTAACG GCTTTATCTC 29700 AGGTTACATG GGCACAACCC TAGGCTTCCC TGGCCTTGAG CTGTTCTTCC GTAACTTAGA 29760 CGGTAGCGGT GAGTTACTAC GTGAAGTAGA TTTACGTGGT AAAACCATCC GTAACGACTC 29820 ACGTTTATTA TCAACAGTGA TGGCCGGCAC TAACATCATC CAAAGCTTTA GCTTCGAGCT 29880 AAGCACTGAC GGTGAGCCTT TCTATCGCGG CACTGCGGTA TTTGGCTATT TTAAAGGTGA 29940 CGCACTTAAA GATCAGCTAG GCCTAGATAA CGGTAAAGTC ACTCAGCCAT GGCATGTAGC 30000 TAACGGCGTT GCTGCAAGCA CTAAGGTGAA CCTGCTTGAT AAGAGCTGCC GTCACTTTAA 30060 TGCGCCAGCT AACCAGCCAC ACTATCGTCT AGCCGGTGGT CAGCTGAACT TTATCGACAG 30120 TGTTGAAATT GTTGATAATG GCGGCACCGA AGGTTTAGGT TACTTGTATG CCGAGCGCAC 30180 CATTGACCCA AGTGATTGGT TCTTCCAGTT CCACTTCCAC CAAGATCCGG TTATGCCAGG 30240 CTCCTTAGGT GTTGAAGCAA TTATTGAAAC CATGCAAGCT TACGCTATTA GTAAAGACTT 30300 GGGCGCAGAT TTCAAAAATC CTAAGTTTGG TCAGATTTTA TCGAACATCA AGTGGAAGTA 30360 TCGCGGTCAA ATCAATCCGC TGAACAAGCA GATGTCTATG GATGTCAGCA TTACTTCAAT 30420 CAAAGATGAA GACGGTAAGA AAGTCATCAC AGGTAATGCC AGCTTGAGTA AAGATGGTCT 30480 GCGCATATAC GAGGTCTTCG ATATAGCTAT CAGCATCGAA GAATCTGTAT AAATCGGAGT 30540 GACTGTCTGG CTATTTTACT CAATTTCTGT GTCAAAAGTG CTCACCTATA TTCATAGGCT 30600 GCGCGCTTTT TTCTGGAAAT TGAGCAAAAG TATCTGCGTC CTAACTCGAT TTATAAGAAT 30660 GGTTTAATTG AAAAGAACAA CAGCTAAGAG CCGCAAGCTC AATATAAATA ATTAAGGGTC 30720 TTACAAATAA TGAATCCTAC AGCAACTAAC GAAATGCTTT CTCCGTGGCC ATGGGCTGTG 30780 ACAGAGTCAA ATATCAGTTT TGACGTGCAA GTGATGGAAC AACAACTTAA AGATTTTAGC 30840 CGGGCATGTT ACGTGGTCAA TCATGCCGAC CACGGCTTTG GTATTGCGCA AACTGCCGAT 30900 ATCGTGACTG AACAAGCGGC AAACAGCACA GATTTACCTG TTAGTGCTTT TACTCCTGCA 30960 TTAGGTACCG AAAGCCTAGG CGACAATAAT TTCCGCCGCG TTCACGGCGT TAAATACGCT 31020 TATTACGCAG GCGCTATGGC AAACGGTATT TCATCTGAAG AGCTAGTGAT TGCCCTAGGT 31080 CAAGCTGGCA TTTTGTGTGG TTCGTTTGGA GCAGCCGGTC TTATTCCAAG TCGCGTTGAA 31140 GCGGCAATTA ACCGTATTCA AGCAGCGCTG CCAAATGGCC CTTATATGTT TAACCTTATC 31200 CATAGTCCTA GCGAGCCAGC ATTAGAGCGT GGCAGCGTAG AGCTATTTTT AAAGCATAAG 31260 GTACGCACCG TTGAAGCATC AGCTTTCTTA GGTCTAACAC CACAAATCGT CTATTACCGT 31320 GCAGCAGGAT TGAGCCGAGA CGCACAAGGT AAAGTTGTGG TTGGTAACAA GGTTATCGCT 31380 AAAGTAAGTC GCACCGAAGT GGCTGAAAAG TTTATGATGC CAGCGCCCGC AAAAATGCTA 31440 CAAAAACTAG TTGATGACGG TTCAATTACC GCTGAGCAAA TGGAGCTGGC GCAACTTGTA 31500 CCTATGGCTG ACGACATCAC TGCAGAGGCC GATTCAGGTG GCCATACTGA TAACCGTCCA 31560 TTAGTAACAT TGCTGCCAAC CATTTTAGCG CTGAAAGAAG AAATTCAAGC TAAATACCAA 31620 TACGACACTC CTATTCGTGT CGGTTGTGGT GGCGGTGTGG GTACGCCTGA TGCAGCGCTG 31680 GCAACGTTTA ACATGGGCGC GGCGTATATT GTTACCGGCT CTATCAACCA AGCTTGTGTT 31740 GAAGCGGGCG CAAGTGATCA CACTCGTAAA TTACTTGCCA CCACTGAAAT GGCCGATGTG 31800 ACTATGGCAC CAGCTGCAGA TATGTTCGAG ATGGGCGTAA AACTGCAGGT GGTTAAGCGC 31860 GGCACGCTAT TCCCAATGCG CGCTAACAAG CTATATGAGA TCTACACCCG TTACGATTCA 31920 ATCGAAGCGA TCCCATTAGA CGAGCGTGAA AAGCTTGAGA AACAAGTATT CCGCTCAAGC 31980 CTAGATGAAA TATGGGCAGG TACAGTGGCG CACTTTAACG AGCGCGACCC TAAGCAAATC 32040 GAACGCGCAG AGGGTAACCC TAAGCGTAAA ATGGCATTGA TTTTCCGTTG GTACTTAGGT 32100 CTTTCTAGTC GCTGGTCAAA CTCAGGCGAA GTGGGTCGTG AAATGGATTA TCAAATTTGG 32160 GCTGGCCCTG CTCTCGGTGC ATTTAACCAA TGGGCAAAAG GCAGTTACTT AGATAACTAT 32220 CAAGACCGAA ATGCCGTCGA TTTGGCAAAG CACTTAATGT ACGGCGCGGC TTACTTAAAT 32280 CGTATTAACT CGCTAACGGC TCAAGGCGTT AAAGTGCCAG CACAGTTACT TCGCTGGAAG 32340 CCAAACCAAA GAATGGCCTA ATACACTTAC AAAGCACCAG TCTAAAAAGC CACTAATCTT 32400 GATTAGTGGC TTTTTTTATT GTGGTCAATA TGAGGCTATT TAGCCTGTAA GCCTGAAAAT 32460 ATCAGCACTC TGACTTTACA AGCAAATTAT AATTAAGGCA GGGCTCTACT CATTTATACT 32520 GCTAGCAAAC AAGCAAGTTG CCCAGTAAAA CAACAAGGTA CCTGATTTAT ATCGTCATAA 32580 AAGTTGGCTA GAGATTCGTT ATTGATCTTT ACTGATTAGA GTCGCTCTGT TTGGAAAAAG 32640 GTTTCTCGTT ATCATCAAAA TACACTCTCA AACCTTTAAT CAATTACAAC TTAGGCTTTC 32700 TGCGGGCATT TTTATCTTAT TTGCCACAGC TGTATTTGCC TTTAGGTTTT GGGTGCAACT 32760 ACCATTAATT GAGGCCTCAT TAGTTAAATT ATCTGAGCAA GAGCTCACCT CTTTAAATTA 32820 CGCTTTTCAG CAAATGAGAA AGCCACTACA AACCATTAAT TACGACTATG CGGTGTGGGA 32880 CAGAACCTAC AGCTATATGA AATCAAACTC AGCGAGCGCT AAAAGGTACT ATGAAAAACA 32940 TGAGTACCCA GATGATACGT TCAAGAGTTT AAAAGTCGAC GGAGTATTTA TATTCAACCG 33000 TACAAATCAG CCAGTTTTTA GTAAAGGTTT TAATCATAGA AATGATATAC CGCTGGTCTT 33060 TGAATTAACT GACTTTAAAC AACATCCACA AAACATCGCA TTATCTCCAC AAACCAAACA 33120 GGCACACCCA CCGGCAAGTA AGCCGTTAGA CTCCCCTGAT GATGTGCCTT CTACCCATGG 33180 GGTTATCGCC ACACGATACG GTCCAGCAAT TTATAGCTCT ACCAGCATTT TAAAATCTGA 33240 TCGTAGCGGC TCCCAACTTG GTTATTTAGT CTTCATTAGG TTAATTGATG AATGGTTCAT 33300 CGCTGAGCTA TCGCAATACA CTGCCGCAGG TGTTGAAATC GCTATGGCTG ATGCCGCAGA 33360 CGCACAATTA GCGAGATTAG GCGCAAACAC TAAGCTTAAT AAAGTAACCG CTACATCCGA 33420 ACGGTTAATA ACTAATGTCG ATGGTAAGCC TCTGTTGAAG TTAGTGCTTT ACCATACCAA 33480 TAACCAACCG CCGCCGATGC TAGATTACAG TATAATAATT CTATTAGTTG AGATGTCATT 33540 TTTACTGATC CTCGCTTATT TCCTTTACTC CTACTTCTTA GTCAGGCCAG TTAGAAAGCT 33600 GGCTTCAGAT ATTAAAAAAA TGGATAAAAG TCGTGAAATT AAAAAGCTAA GGTATCACTA 33660 CCCTATTACT GAGCTAGTCA AAGTTGCGAC TCACTTCAAC GCCCTAATGG GGACGATTCA 33720 GGAACAAACT AAACAGCTTA ATGAACAAGT TTTTATTGAT AAATTAACCA ATATTCCCAA 33780 TCGTCGCGCT TTTGAGCAGC GACTTGAAAC CTATTGCCAA CTGCTAGCCC GGCAACAAAT 33840 TGGCTTTACT CTCATCATTG CCGATGTGGA TCATTTTAAA GAGTACAACG ATACTCTTGG 33900 GCACCTTGCT GGGGATGAAG CATTAATAAA AGTGGCACAA ACACTATCGC AACAGTTTTA 33960 CCGTGCAGAA GATATTTGTG CCCGTTTTGG TGGTGAAGAA TTTATTATGT TATTTCGAGA 34020 CATACCTGAT GAGCCCTTGC AGAGAAAGCT CGATGCGATG CTGCACTCTT TTGCAGAGCT 34080 CAACCTACCT CATCCAAACT CATCAACCGC TAATTACGTT ACTGTGAGCC TTGGGGTTTG 34140 CACAGTTGTT GCTGTTGATG ATTTTGAATT TAAAAGTGAG TCGCATATTA TTGGCAGTCA 34200 GGCTGCATTA ATCGCAGATA AGGCGCTTTA TCATGCTAAA GCCTGTGGTC GTAACCAGTT 34260 GTCAAAAACT ACTATTACTG TTGATGAGAT TGAGCAATTA GAAGCAAATA AAATCGGTCA 34320 TCAAGCCTAA ACTCGTTCGA GTACTTTCCC CTAAGTCAGA GCTATTTGCC ACTTCAAGAT 34380 GTGGCTACAA GGCTTACTCT TTCAAAACCT GCATCAATAG AACACAGCAA AATACAATAA 34440 TTTAAGTCAA TTTAGCCTAT TAAACAGAGT TAATGACAGC TCATGGTCGC AACTTATTAG 34500 CTATTTCTAG CAATATAAAA ACTTATCCAT TAGTAGTAAC CAATAAAAAA ACTAATATAT 34560 AAAACTATTT AATCATTATT TTACAGATGA TTAGCTACCA CCCACCTTAA GCTGGCTATA 34620 TTCGCACTAG TAAAAATAAA CATTAGATCG GGTTCAGATC AATTTACGAG TCTCGTATAA 34680 AATGTACAAT AATTCACTTA ATTTAATACT GCATATTTTT ACAAGTAGAG AGCGGTGATG 34740 AAACAAAATA CGAAAGGCTT TACATTAATT GAATTAGTCA TCGTGATTAT TATTCTCGGT 34800 ATACTTGCTG CTGTGGCACT GCCGAAATTC ATCAATGTTC AAGATGACGC TAGGATCTCT 34860 GCGATGAGCG GTCAGTTTTC ATCATTTGAA AGTGCCGTAA AACTATACCA TAGCGGTTGG 34920 TTAGCCAAAG GCTACAACAC TGCGGTTGAA AAGCTCTCAG GCTTTGGCCA AGGTAATGTT 34980 GCATCAAGTG ACACAGGTTT TCCGTACTCA ACATCAGGCA CGAGTACTGA TGTGCATAAA 35040 GCTTGTGGTG AACTATGGCA TGGCATTACC GATACAGACT TCACAATTGG TGCGGTTAGT 35100 GATGGCGATC TAATGACTGC AGATGTCGAT ATTGCTTACA CCTATCGTGG TGATATGTGT 35160 ATCTATCGCG ATCTGTATTT TATTCAGCGC TCATTACCTA CTAAGGTGAT GAACTACAAA 35220 TTTAAAACTG GTGAAATAGA AATTATTGAT GCTTTCTACA ACCCTGACGG CTCAACTGGT 35280 CAATTACCAT AAATTTGGCG CTTATCTAAG TTGTACTTGC TCTGACCGAC ACAAATAATG 35340 TCGTTTCTCA GCATATATCA AAATACACAG CAAAAATTTG GGGTTAGCTA TATAGCTAAC 35400 CCCAAATCAT ATCTAACTTT ACACTGCATC TAATTCCAAA CAGTATCCAG CCAAAAGCCT 35460 AAACTATTGT TGACTCAGCG CTAAAATATG CGATGCAACA AACAAGTCTT GGATCGCAAT 35520 ACCTGAGCTA TCAAAAATGG TCACCTCATC AGCACTTTGA CGTCCTGTTG CGGACTCGTT 35580 TATCACCTGA CCAATCTCAA TTATCGGCGT ATTTCTGCTA TGTTGAAACT CACCAATAAC 35640 AATAGATTGA GAAGCAAAGT CGCAAAACAA GCGAGCATGA CTATATAGGT CAGTTGGCAA 35700 CTCTTGCTTA CCCACTTTAT CAGCGCCCAT TGCAGAAATA TGCGTTCCTG CTTGTACCCA 35760 CTGCGCTTCA AATAAAGGCG CTTGAGCTGT GGTTGCTGTG ATAATAATAT CTGCTTGTTC 35820 ACAAGCAGCT TGTGCATCAC AAGCTTCGGC ATTAATGCCT TTTTCTAATA AACGCTTAAC 35880 CAAGTTTTCA GTTTTGCTAG CACTACGGCC AACTACCAAT ACCTTAGTTA ATGAACGAAC 35940 CTTGCTCACT GCTAGCACTT CATATTCAGC CTGATGACCG GTACCAAAAA CAGTTAATAC 36000
【００４９】 CGTAGCATCT TCTCTCGCGA GGTAACTCAC TGCTACTGCA TCGGCAGCAC CAGTGCGGTA 36060 AGCATTAACG GTAGTGGCAG CAATCACCGN CTGCAACATA CCGGTTAATG GATCGAGTAA 36120 AAATACGTTA GTGCCGTGGC ATGGTAAACC ATGTTTATGG TTATCAGGCC AATAGCTGCC 36180 TGTTTTCCAG CCGACAAGGT TTGGCGTTGA AGCCGACTTT AATGAGAACA TTTCATTAAG 36240 GTTCGCGCCC TGTGCATTAA CTACCGGGAA CAAGGTTGCT TTATCATCTA CGGCAGCGAC 36300 AAACGCTTCT TTAACAGCGA TATAAGCCAG CTCATGGGAG ATGAGCTTTG ATGTTTGCGC 36360 TTCAGTTAAA TAGATCATAT TACCACCCCT GCACTCGATT CCAGATCTCA TAGCCACCAT 36420 TATCACCATC AGTATCAAAT ACATGGTACT GAGCGTGCAT TGAAGCTGTT GCACAGGCGT 36480 GGTTCGGCAA AATATGTAGA CGACTACCTA CCGGGAACTG CGCTAAATCA ATAACGCCGC 36540 CATCAACTGC TTCAATAATG CCGTGCTCTT GATTAACAGT TATAACCTGT AGACCTGATA 36600 ACACGTGACC GCTGTCGTCA CACACTAAAC CATAACCACA ATCTTTTGGC TGCTCTGCAG 36660 TACCTCTATC ACCCGAAAGA GCCATCCAAC CCGCATCAAT GAAAATCCAG TTTTTATCAG 36720 GATTATGACC AATAACACTG GTCACTACCG TTGCGGCAAT ATCAGTTAAC TGACACACGT 36780 TTAGCCCTGC CATGACTAAA TCGAAGAAGG TGTACACACC CGCTCTAACC TCGGTGATCC 36840 CATCAAGGTT TTGATAGCTT TGCGCTGTTG GTGTTGAACC AATACTAACG ATGTCACATT 36900 GCATACCCGC TGCGCGAATG CGTCAGCAGC TTGTACAGCC GCTGCAACTT CATTTTGCGC 36960 CGCATCAATT AATTGCTGTT TTTCAAAACA TTGATATGAC TCACCAGCGT GAGTGAGTAC 37020 GCCGTGAAAA CTCGCTGCGC CAGACGTTAG TATCTGAGCA ATTTCAATCA ACTTATCGGC 37080 TTCCGGTGGA ATACCACCAC GATGGCCATC ACAATCAATT TCAATTAATG CTGGTATTTG 37140 GCAGTCATAA GAACCACAGA AATGATTTAG CTGATGCGCT TGCTCAACAC TATCAAGTAA 37200 AACTCTTGCA TTAATACCTT GGTCCAACAT TTTAGCAATA CGCGGCAACT TACCATCGGC 37260 AATACCTACT GCATAAATAA TGTCTGTGTA ACCTTTAGAT GCTAAGGCCT CGGCCTCTTT 37320 TACCGTTGAT ACAGTGACTG GTGAGTTTTT AGTGGGTAAT AAAAACTCGG CTGCTTCAAG 37380 TGATCTTAAC GTTTTAAAAT GCGGTCTTAG GTTTGCACCT AATCCTTCAA TTTTTTGGCG 37440 TAGTTGACTG AGGTTATTAA TAAATACTGG CTTATTTACA TATAAAAACG GTGTATCAAT 37500 TGCTTGATAC TGACTTTGCT GAGTCGTGGA AAGTATTTGA GTAGATGGCA TCTTTAATAT 37560 CCTAGTTCAT CAATCAATCT AACAAGTTTG ATGCCTAGCC ACAGTGGCTT GTATTCATGA 37620 TGCTTTGGAA AATGCTTATA TTCAAAGTAT TTGAAAGACA TCAAACTTCT TGTTTAATGC 37680 TCAGTATCCA CCAGCACGCA TTTATTTTAT ATTAACTATT ATCAAGATAT AGATTAGGTT 37740 CAAACCAAAT GATTAGTACT GAAGATCTAC GTTTTATCAG CGTAATCGCC AGTCATCGCA 37800 CCTTAGCTGA TGCCGCTAGA ACACTAAATA TCACGCCACC ATCAGTGACA TTAAGGTTGC 37860 AGCATATTGA AAAGAAACTA TCGATTAGCC TGATC 37895
【００５０】配列番号： ２ 配列の長さ：１９８３ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AAA CAG ACT CTA ATG GCT ATC TCA ATC ATG TCG CTT TTT TCA TTC 48 Met Lys Gln Thr Leu Met Ala Ile Ser Ile Met Ser Leu Phe Ser Phe 1 5 10 15 AAT GCG CTA GCA GCG CAA CAT GAA CAT GAC CAC ATC ACT GTT GAT TAC 96 Asn Ala Leu Ala Ala Gln His Glu His Asp His Ile Thr Val Asp Tyr 20 25 30 GAA GGG AAA GCC GCA ACA GAA CAC ACC ATA GCT CAC AAC CAA GCT GTA 144 Glu Gly Lys Ala Ala Thr Glu His Thr Ile Ala His Asn Gln Ala Val 35 40 45 GCT AAA ACA CTT AAC TTT GCC GAC ACG CGT GCA TTT GAG CAA TCG TCT 192 Ala Lys Thr Leu Asn Phe Ala Asp Thr Arg Ala Phe Glu Gln Ser Ser 50 55 60 AAA AAT CTA GTC GCC AAG TTT GAT AAA GCA ACT GCC GAT ATA TTA CGT 240 Lys Asn Leu Val Ala Lys Phe Asp Lys Ala Thr Ala Asp Ile Leu Arg 65 70 75 80 GCC GAA TTT GCT TTT ATT AGC GAT GAA ATC CCT GAC TCG GTT AAC CCG 288 Ala Glu Phe Ala Phe Ile Ser Asp Glu Ile Pro Asp Ser Val Asn Pro 85 90 95 TCT CTC TAC CGT CAG GCT CAG CTT AAT ATG GTG CCT AAT GGT CTG TAT 336 Ser Leu Tyr Arg Gln Ala Gln Leu Asn Met Val Pro Asn Gly Leu Tyr 100 105 110 AAA GTG AGC GAT GGC ATT TAC CAG GTC CGC GGT ACC GAC TTA TCT AAC 384 Lys Val Ser Asp Gly Ile Tyr Gln Val Arg Gly Thr Asp Leu Ser Asn 115 120 125 CTT ACA CTT ATC CGC AGT GAT AAC GGT TGG ATA GCA TAC GAT GTT TTG 432 Leu Thr Leu Ile Arg Ser Asp Asn Gly Trp Ile Ala Tyr Asp Val Leu 130 135 140 TTA ACC AAA GAA GCA GCA AAA GCC TCA CTA CAA TTT GCG TTA AAG AAT 480 Leu Thr Lys Glu Ala Ala Lys Ala Ser Leu Gln Phe Ala Leu Lys Asn 145 150 155 160 CTA CCT AAA GAT GGC GAT TTA CCC GTT GTT GCG ATG ATT TAC TCC CAT 528 Leu Pro Lys Asp Gly Asp Leu Pro Val Val Ala Met Ile Tyr Ser His 165 170 175 AGC CAT GCG GAC CAC TTT GGC GGA GCT CGC GGT GTT CAA GAG ATG TTC 576 Ser His Ala Asp His Phe Gly Gly Ala Arg Gly Val Gln Glu Met Phe 180 185 190 CCT GAT GTC AAA GTC TAC GGC TCA GAT AAC ATC ACT AAA GAA ATT GTC 624 Pro Asp Val Lys Val Tyr Gly Ser Asp Asn Ile Thr Lys Glu Ile Val 195 200 205 GAT GAG AAC GTA CTT GCC GGT AAC GCC ATG AGC CGC CGC GCA GCT TAT 672 Asp Glu Asn Val Leu Ala Gly Asn Ala Met Ser Arg Arg Ala Ala Tyr 210 215 220 CAA TAC GGC GCA ACA CTG GGC AAA CAT GAC CAC GGT ATT GTT GAT GCT 720 Gln Tyr Gly Ala Thr Leu Gly Lys His Asp His Gly Ile Val Asp Ala 225 230 235 240 GCG CTA GGT AAA GGT CTA TCA AAA GGT GAA ATC ACT TAC GTC GCC CCA 768 Ala Leu Gly Lys Gly Leu Ser Lys Gly Glu Ile Thr Tyr Val Ala Pro 245 250 255 GAC TAC ACC TTA AAC AGT GAA GGC AAA TGG GAA ACG CTG ACG ATT GAT 816 Asp Tyr Thr Leu Asn Ser Glu Gly Lys Trp Glu Thr Leu Thr Ile Asp 260 265 270 GGT CTA GAG ATG GTG TTT ATG GAT GCC TCG GGC ACC GAA GCT GAG TCA 864 Gly Leu Glu Met Val Phe Met Asp Ala Ser Gly Thr Glu Ala Glu Ser 275 280 285 GAA ATG ATC ACT TAT ATT CCC TCT AAA AAA GCG CTC TGG ACG GCG GAG 912 Glu Met Ile Thr Tyr Ile Pro Ser Lys Lys Ala Leu Trp Thr Ala Glu 290 295 300 CTT ACC TAT CAA GGT ATG CAC AAC ATT TAT ACG CTG CGC GGC GCT AAA 960 Leu Thr Tyr Gln Gly Met His Asn Ile Tyr Thr Leu Arg Gly Ala Lys 305 310 315 320 GTA CGT GAT GCG CTC AAG TGG TCA AAA GAT ATC AAC GAA ATG ATC AAT 1008 Val Arg Asp Ala Leu Lys Trp Ser Lys Asp Ile Asn Glu Met Ile Asn 325 330 335 GCC TTT GGT CAA GAT GTC GAA GTG CTG TTT GCC TCG CAC TCT GCG CCA 1056 Ala Phe Gly Gln Asp Val Glu Val Leu Phe Ala Ser His Ser Ala Pro 340 345 350 GTG TGG GGT AAC CAA GCG ATC AAC GAT TTC TTA CGC CTA CAG CGT GAT 1104 Val Trp Gly Asn Gln Ala Ile Asn Asp Phe Leu Arg Leu Gln Arg Asp 355 360 365 AAC TAC GGC CTA GTG CAC AAT CAA ACC TTG AGA CTT GCC AAC GAT GGT 1152 Asn Tyr Gly Leu Val His Asn Gln Thr Leu Arg Leu Ala Asn Asp Gly 370 375 380 GTC GGT ATA CAA GAT ATT GGC GAT GCG ATT CAA GAC ACG ATT CCA GAG 1200 Val Gly Ile Gln Asp Ile Gly Asp Ala Ile Gln Asp Thr Ile Pro Glu 385 390 395 400 TCT ATC TAC AAG ACG TGG CAT ACC AAT GGT TAC CAC GGC ACT TAT AGC 1248 Ser Ile Tyr Lys Thr Trp His Thr Asn Gly Tyr His Gly Thr Tyr Ser 405 410 415 CAT AAC GCT AAA GCG GTT TAT AAC AAG TAT CTA GGC TAC TTC GAT ATG 1296 His Asn Ala Lys Ala Val Tyr Asn Lys Tyr Leu Gly Tyr Phe Asp Met 420 425 430 AAC CCA GCC AAC CTT AAT CCG CTG CCA ACC AAG CAA GAA TCT GCC AAG 1344 Asn Pro Ala Asn Leu Asn Pro Leu Pro Thr Lys Gln Glu Ser Ala Lys 435 440 445 TTT GTC GAA TAC ATG GGC GGC GCA GAT GCC GCA ATT AAG CGC GCT AAA 1392 Phe Val Glu Tyr Met Gly Gly Ala Asp Ala Ala Ile Lys Arg Ala Lys 450 455 460 GAT GAT TAC GCT CAA GGT GAA TAC CGC TTT GTT GCA ACG GCA TTA AAT 1440 Asp Asp Tyr Ala Gln Gly Glu Tyr Arg Phe Val Ala Thr Ala Leu Asn 465 470 475 480 AAG GTG GTG ATG GCC GAG CCA GAA AAT GAC TCC GCT CGT CAA TTG CTA 1488 Lys Val Val Met Ala Glu Pro Glu Asn Asp Ser Ala Arg Gln Leu Leu 485 490 495 GCC GAT ACC TAT GAG CAA CTT GGT TAT CAA GCA GAA GGG GCT GGC TGG 1536 Ala Asp Thr Tyr Glu Gln Leu Gly Tyr Gln Ala Glu Gly Ala Gly Trp 500 505 510 AGA AAC ATT TAC TTA ACT GGC GCA CAA GAG CTA CGA GTA GGT ATT CAA 1584 Arg Asn Ile Tyr Leu Thr Gly Ala Gln Glu Leu Arg Val Gly Ile Gln 515 520 525 GCT GGC GCG CCT AAA ACC GCA TCG GCA GAT GTC ATC AGT GAA ATG GAC 1632 Ala Gly Ala Pro Lys Thr Ala Ser Ala Asp Val Ile Ser Glu Met Asp 530 535 540 ATG CCG ACT CTA TTT GAC TTC CTC GCG GTG AAG ATT GAT AGT CAA CAG 1680 Met Pro Thr Leu Phe Asp Phe Leu Ala Val Lys Ile Asp Ser Gln Gln 545 550 555 560 GCG GCT AAG CAC GGC TTA GTT AAG ATG AAT GTT ATC ACC CCT GAT ACT 1728 Ala Ala Lys His Gly Leu Val Lys Met Asn Val Ile Thr Pro Asp Thr 565 570 575 AAA GAT ATT CTC TAT ATT GAG CTA AGC AAC GGT AAC TTA AGC AAC GCA 1776 Lys Asp Ile Leu Tyr Ile Glu Leu Ser Asn Gly Asn Leu Ser Asn Ala 580 585 590 GTG GTC GAC AAA GAG CAA GCA GCT GAC GCA AAC CTT ATG GTT AAT AAA 1824 Val Val Asp Lys Glu Gln Ala Ala Asp Ala Asn Leu Met Val Asn Lys 595 600 605 GCT GAC GTT AAC CGC ATC TTA CTT GGC CAA GTA ACC CTA AAA GCG TTA 1872 Ala Asp Val Asn Arg Ile Leu Leu Gly Gln Val Thr Leu Lys Ala Leu 610 615 620 TTA GCC AGC GGC GAT GCC AAG CTC ACT GGT GAT AAA ACG GCA TTT AGT 1920 Leu Ala Ser Gly Asp Ala Lys Leu Thr Gly Asp Lys Thr Ala Phe Ser 625 630 635 640 AAA ATA GCC GAT AGC ATG GTC GAG TTT ACA CCT GAC TTC GAA ATC GTA 1968 Lys Ile Ala Asp Ser Met Val Glu Phe Thr Pro Asp Phe Glu Ile Val 645 650 655 CCA ACG CCT GTT AAA 1983 Pro Thr Pro Val Lys 660
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AAA CAG ACT CTA ATG GCT ATC TCA ATC ATG TCG CTT TTT TCA TTC 48 Met Lys Gln Thr Leu Met Ala Ile Ser Ile Met Ser Leu Phe Ser Phe 1 5 10 15 AAT GCG CTA GCA GCG CAA CAT GAA CAT GAC CAC ATC ACT GTT GAT TAC 96 Asn Ala Leu Ala Ala Gln His Glu His Asp His Ile Thr Val Asp Tyr 20 25 30 GAA GGG AAA GCC GCA ACA GAA CAC ACC ATA GCT CAC AAC CAA GCT GTA 144 Glu Gly Lys Ala Ala Thr Glu His Thr Ile Ala His Asn Gln Ala Val 35 40 45 GCT AAA ACA CTT AAC TTT GCC GAC ACG CGT GCA TTT GAG CAA TCG TCT 192 Ala Lys Thr Leu Asn Phe Ala Asp Thr Arg Ala Phe Glu Gln Ser Ser 50 55 60 AAA AAT CTA GTC GCC AAG TTT GAT AAA GCA ACT GCC GAT ATA TTA CGT 240 Lys Asn Leu Val Ala Lys Phe Asp Lys Ala Thr Ala Asp Ile Leu Arg 65 70 75 80 GCC GAA TTT GCT TTT ATT AGC GAT GAA ATC CCT GAC TCG GTT AAC CCG 288 Ala Glu Phe Ala Phe Ile Ser Asp Glu Ile Pro Asp Ser Val Asn Pro 85 90 95 TCT CTC TAC CGT CAG GCT CAG CTT AAT ATG GTG CCT AAT GGT CTG TAT 336 Ser Leu Tyr Arg Gln Ala Gln Leu Asn Met Val Pro Asn Gly Leu Tyr 100 105 110 AAA GTG AGC GAT GGC ATT TAC CAG GTC CGC GGT ACC GAC TTA TCT AAC 384 Lys Val Ser Asp Gly Ile Tyr Gln Val Arg Gly Thr Asp Leu Ser Asn 115 120 125 CTT ACA CTT ATC CGC AGT GAT AAC GGT TGG ATA GCA TAC GAT GTT TTG 432 Leu Thr Leu Ile Arg Ser Asp Asn Gly Trp Ile Ala Tyr Asp Val Leu 130 135 140 TTA ACC AAA GAA GCA GCA AAA GCC TCA CTA CAA TTT GCG TTA AAG AAT 480 Leu Thr Lys Glu Ala Ala Lys Ala Ser Leu Gln Phe Ala Leu Lys Asn 145 150 155 160 CTA CCT AAA GAT GGC GAT TTA CCC GTT GTT GCG ATG ATT TAC TCC CAT 528 Leu Pro Lys Asp Gly Asp Leu Pro Val Val Ala Met Ile Tyr Ser His 165 170 175 AGC CAT GCG GAC CAC TTT GGC GGA GCT CGC GGT GTT CAA GAG ATG TTC 576 Ser His Ala Asp His Phe Gly Gly Ala Arg Gly Val Gln Glu Met Phe 180 185 190 CCT GAT GTC AAA GTC TAC GGC TCA GAT AAC ATC ACT AAA GAA ATT GTC 624 Pro Asp Val Lys Val Tyr Gly Ser Asp Asn Ile Thr Lys Glu Ile Val 195 200 205 GAT GAG AAC GTA CTT GCC GGT AAC GCC ATG AGC CGC CGC GCA GCT TAT 672 Asp Glu Asn Val Leu Ala Gly Asn Ala Met Ser Arg Arg Ala Ala Tyr 210 215 220 CAA TAC GGC GCA ACA CTG GGC AAA CAT GAC CAC GGT ATT GTT GAT GCT 720 Gln Tyr Gly Ala Thr Leu Gly Lys His Asp His Gly Ile Val Asp Ala 225 230 235 240 GCG CTA GGT AAA GGT CTA TCA AAA GGT GAA ATC ACT TAC GTC GCC CCA 768 Ala Leu Gly Lys Gly Leu Ser Lys Gly Glu Ile Thr Tyr Val Ala Pro 245 250 255 GAC TAC ACC TTA AAC AGT GAA GGC AAA TGG GAA ACG CTG ACG ATT GAT 816 Asp Tyr Thr Leu Asn Ser Glu Gly Lys Trp Glu Thr Leu Thr Ile Asp 260 265 270 GGT CTA GAG ATG GTG TTT ATG GAT GCC TCG GGC ACC GAA GCT GAG TCA 864 Gly Leu Glu Met Val Phe Met Asp Ala Ser Gly Thr Glu Ala Glu Ser 275 280 285 GAA ATG ATC ACT TAT ATT CCC TCT AAA AAA GCG CTC TGG ACG GCG GAG 912 Glu Met Ile Thr Tyr Ile Pro Ser Lys Lys Ala Leu Trp Thr Ala Glu 290 295 300 CTT ACC TAT CAA GGT ATG CAC AAC ATT TAT ACG CTG CGC GGC GCT AAA 960 Leu Thr Tyr Gln Gly Met His Asn Ile Tyr Thr Leu Arg Gly Ala Lys 305 310 315 320 GTA CGT GAT GCG CTC AAG TGG TCA AAA GAT ATC AAC GAA ATG ATC AAT 1008 Val Arg Asp Ala Leu Lys Trp Ser Lys Asp Ile Asn Glu Met Ile Asn 325 330 335 GCC TTT GGT CAA GAT GTC GAA GTG CTG TTT GCC TCG CAC TCT GCG CCA 1056 Ala Phe Gly Gln Asp Val Glu Val Leu Phe Ala Ser His Ser Ala Pro 340 345 350 GTG TGG GGT AAC CAA GCG ATC AAC GAT TTC TTA CGC CTA CAG CGT GAT 1104 Val Trp Gly Asn Gln Ala Ile Asn Asp Phe Leu Arg Leu Gln Arg Asp 355 360 365 AAC TAC GGC CTA GTG CAC AAT CAA ACC TTG AGA CTT GCC AAC GAT GGT 1152 Asn Tyr Gly Leu Val His Asn Gln Thr Leu Arg Leu Ala Asn Asp Gly 370 375 380 GTC GGT ATA CAA GAT ATT GGC GAT GCG ATT CAA GAC ACG ATT CCA GAG 1200 Val Gly Ile Gln Asp Ile Gly Asp Ala Ile Gln Asp Thr Ile Pro Glu 385 390 395 400 TCT ATC TAC AAG ACG TGG CAT ACC AAT GGT TAC CAC GGC ACT TAT AGC 1248 Ser Ile Tyr Lys Thr Trp His Thr Asn Gly Tyr His Gly Thr Tyr Ser 405 410 415 CAT AAC GCT AAA GCG GTT TAT AAC AAG TAT CTA GGC TAC TTC GAT ATG 1296 His Asn Ala Lys Ala Val Tyr Asn Lys Tyr Leu Gly Tyr Phe Asp Met 420 425 430 AAC CCA GCC AAC CTT AAT CCG CTG CCA ACC AAG CAA GAA TCT GCC AAG 1344 Asn Pro Ala Asn Leu Asn Pro Leu Pro Thr Lys Gln Glu Ser Ala Lys 435 440 445 TTT GTC GAA TAC ATG GGC GGC GCA GAT GCC GCA ATT AAG CGC GCT AAA 1392 Phe Val Glu Tyr Met Gly Gly Ala Asp Ala Ala Ile Lys Arg Ala Lys 450 455 460 GAT GAT TAC GCT CAA GGT GAA TAC CGC TTT GTT GCA ACG GCA TTA AAT 1440 Asp Asp Tyr Ala Gln Gly Glu Tyr Arg Phe Val Ala Thr Ala Leu Asn 465 470 475 480 AAG GTG GTG ATG GCC GAG CCA GAA AAT GAC TCC GCT CGT CAA TTG CTA 1488 Lys Val Val Met Ala Glu Pro Glu Asn Asp Ser Ala Arg Gln Leu Leu 485 490 495 GCC GAT ACC TAT GAG CAA CTT GGT TAT CAA GCA GAA GGG GCT GGC TGG 1536 Ala Asp Thr Tyr Glu Gln Leu Gly Tyr Gln Ala Glu Gly Ala Gly Trp 500 505 510 AGA AAC ATT TAC TTA ACT GGC GCA CAA GAG CTA CGA GTA GGT ATT CAA 1584 Arg Asn Ile Tyr Leu Thr Gly Ala Gln Glu Leu Arg Val Gly Ile Gln 515 520 525 GCT GGC GCG CCT AAA ACC GCA TCG GCA GAT GTC ATC AGT GAA ATG GAC 1632 Ala Gly Ala Pro Lys Thr Ala Ser Ala Asp Val Ile Ser Glu Met Asp 530 535 540 ATG CCG ACT CTA TTT GAC TTC CTC GCG GTG AAG ATT GAT AGT CAA CAG 1680 Met Pro Thr Leu Phe Asp Phe Leu Ala Val Lys Ile Asp Ser Gln Gln 545 550 555 560 GCG GCT AAG CAC GGC TTA GTT AAG ATG AAT GTT ATC ACC CCT GAT ACT 1728 Ala Ala Lys His Gly Leu Val Lys Met Asn Val Ile Thr Pro Asp Thr 565 570 575 AAA GAT ATT CTC TAT ATT GAG CTA AGC AAC GGT AAC TTA AGC AAC GCA 1776 Lys Asp Ile Leu Tyr Ile Glu Leu Ser Asn Gly Asn Leu Ser Asn Ala 580 585 590 GTG GTC GAC AAA GAG CAA GCA GCT GAC GCA AAC CTT ATG GTT AAT AAA 1824 Val Val Asp Lys Glu Gln Ala Ala Asp Ala Asn Leu Met Val Asn Lys 595 600 605 GCT GAC GTT AAC CGC ATC TTA CTT GGC CAA GTA ACC CTA AAA GCG TTA 1872 Ala Asp Val Asn Arg Ile Leu Leu Gly Gln Val Thr Leu Lys Ala Leu 610 615 620 TTA GCC AGC GGC GAT GCC AAG CTC ACT GGT GAT AAA ACG GCA TTT AGT 1920 Leu Ala Ser Gly Asp Ala Lys Leu Thr Gly Asp Lys Thr Ala Phe Ser 625 630 635 640 AAA ATA GCC GAT AGC ATG GTC GAG TTT ACA CCT GAC TTC GAA ATC GTA 1968 Lys Ile Ala Asp Ser Met Val Glu Phe Thr Pro Asp Phe Glu Ile Val 645 650 655 CCA ACG CCT GTT AAA 1983 Pro Thr Pro Val Lys 660
【００５１】配列番号： ３ 配列の長さ：６６１ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Lys Gln Thr Leu Met Ala Ile Ser Ile Met Ser Leu Phe Ser Phe 1 5 10 15 Asn Ala Leu Ala Ala Gln His Glu His Asp His Ile Thr Val Asp Tyr 20 25 30 Glu Gly Lys Ala Ala Thr Glu His Thr Ile Ala His Asn Gln Ala Val 35 40 45 Ala Lys Thr Leu Asn Phe Ala Asp Thr Arg Ala Phe Glu Gln Ser Ser 50 55 60 Lys Asn Leu Val Ala Lys Phe Asp Lys Ala Thr Ala Asp Ile Leu Arg 65 70 75 80 Ala Glu Phe Ala Phe Ile Ser Asp Glu Ile Pro Asp Ser Val Asn Pro 85 90 95 Ser Leu Tyr Arg Gln Ala Gln Leu Asn Met Val Pro Asn Gly Leu Tyr 100 105 110 Lys Val Ser Asp Gly Ile Tyr Gln Val Arg Gly Thr Asp Leu Ser Asn 115 120 125 Leu Thr Leu Ile Arg Ser Asp Asn Gly Trp Ile Ala Tyr Asp Val Leu 130 135 140 Leu Thr Lys Glu Ala Ala Lys Ala Ser Leu Gln Phe Ala Leu Lys Asn 145 150 155 160 Leu Pro Lys Asp Gly Asp Leu Pro Val Val Ala Met Ile Tyr Ser His 165 170 175 Ser His Ala Asp His Phe Gly Gly Ala Arg Gly Val Gln Glu Met Phe 180 185 190 Pro Asp Val Lys Val Tyr Gly Ser Asp Asn Ile Thr Lys Glu Ile Val 195 200 205 Asp Glu Asn Val Leu Ala Gly Asn Ala Met Ser Arg Arg Ala Ala Tyr 210 215 220 Gln Tyr Gly Ala Thr Leu Gly Lys His Asp His Gly Ile Val Asp Ala 225 230 235 240 Ala Leu Gly Lys Gly Leu Ser Lys Gly Glu Ile Thr Tyr Val Ala Pro 245 250 255 Asp Tyr Thr Leu Asn Ser Glu Gly Lys Trp Glu Thr Leu Thr Ile Asp 260 265 270 Gly Leu Glu Met Val Phe Met Asp Ala Ser Gly Thr Glu Ala Glu Ser 275 280 285 Glu Met Ile Thr Tyr Ile Pro Ser Lys Lys Ala Leu Trp Thr Ala Glu 290 295 300 Leu Thr Tyr Gln Gly Met His Asn Ile Tyr Thr Leu Arg Gly Ala Lys 305 310 315 320 Val Arg Asp Ala Leu Lys Trp Ser Lys Asp Ile Asn Glu Met Ile Asn 325 330 335 Ala Phe Gly Gln Asp Val Glu Val Leu Phe Ala Ser His Ser Ala Pro 340 345 350 Val Trp Gly Asn Gln Ala Ile Asn Asp Phe Leu Arg Leu Gln Arg Asp 355 360 365 Asn Tyr Gly Leu Val His Asn Gln Thr Leu Arg Leu Ala Asn Asp Gly 370 375 380 Val Gly Ile Gln Asp Ile Gly Asp Ala Ile Gln Asp Thr Ile Pro Glu 385 390 395 400 Ser Ile Tyr Lys Thr Trp His Thr Asn Gly Tyr His Gly Thr Tyr Ser 405 410 415 His Asn Ala Lys Ala Val Tyr Asn Lys Tyr Leu Gly Tyr Phe Asp Met 420 425 430 Asn Pro Ala Asn Leu Asn Pro Leu Pro Thr Lys Gln Glu Ser Ala Lys 435 440 445 Phe Val Glu Tyr Met Gly Gly Ala Asp Ala Ala Ile Lys Arg Ala Lys 450 455 460 Asp Asp Tyr Ala Gln Gly Glu Tyr Arg Phe Val Ala Thr Ala Leu Asn 465 470 475 480 Lys Val Val Met Ala Glu Pro Glu Asn Asp Ser Ala Arg Gln Leu Leu 485 490 495 Ala Asp Thr Tyr Glu Gln Leu Gly Tyr Gln Ala Glu Gly Ala Gly Trp 500 505 510 Arg Asn Ile Tyr Leu Thr Gly Ala Gln Glu Leu Arg Val Gly Ile Gln 515 520 525 Ala Gly Ala Pro Lys Thr Ala Ser Ala Asp Val Ile Ser Glu Met Asp 530 535 540 Met Pro Thr Leu Phe Asp Phe Leu Ala Val Lys Ile Asp Ser Gln Gln 545 550 555 560 Ala Ala Lys His Gly Leu Val Lys Met Asn Val Ile Thr Pro Asp Thr 565 570 575 Lys Asp Ile Leu Tyr Ile Glu Leu Ser Asn Gly Asn Leu Ser Asn Ala 580 585 590 Val Val Asp Lys Glu Gln Ala Ala Asp Ala Asn Leu Met Val Asn Lys 595 600 605 Ala Asp Val Asn Arg Ile Leu Leu Gly Gln Val Thr Leu Lys Ala Leu 610 615 620 Leu Ala Ser Gly Asp Ala Lys Leu Thr Gly Asp Lys Thr Ala Phe Ser 625 630 635 640 Lys Ile Ala Asp Ser Met Val Glu Phe Thr Pro Asp Phe Glu Ile Val 645 650 655 Pro Thr Pro Val Lys 660
【００５２】配列番号： ４ 配列の長さ：８３１ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG GTA AGA GGC TAT TTG CGC GCT TTA TTG TCA CAA CAT AGT GAA ATA 48 Met Val Arg Gly Tyr Leu Arg Ala Leu Leu Ser Gln His Ser Glu Ile 5 10 15 CGC CCC AAT GAA TGG CGC TTT GAA TAT GGC GAC AAA GGT AAG CCT AGA 96 Arg Pro Asn Glu Trp Arg Phe Glu Tyr Gly Asp Lys Gly Lys Pro Arg 20 25 30 TTG AGT GAT GCG CAA TTT GCT CAA ACC GGG GTC CAC TTT AAT GTG AGT 144 Leu Ser Asp Ala Gln Phe Ala Gln Thr Gly Val His Phe Asn Val Ser 35 40 45 CAT AGT GGA GAT TGG CTA TTA GTA GGC ATT TGC ACT GCT GAT AAT AAA 192 His Ser Gly Asp Trp Leu Leu Val Gly Ile Cys Thr Ala Asp Asn Lys 50 55 60 GGC GCC AGT CAG GCA AGC AAG GAG GAA ACT GAC TCT GCT AGT ATT GAG 240 Gly Ala Ser Gln Ala Ser Lys Glu Glu Thr Asp Ser Ala Ser Ile Glu 65 70 75 80 TTT GGC GTC GAC ATT GAG CGT TGC CGT AAC AGC ACC AAT ATC CAC TCT 288 Phe Gly Val Asp Ile Glu Arg Cys Arg Asn Ser Thr Asn Ile His Ser 85 90 95 ATT CTT AGT CAT TAT TTC TCT GAA TCA GAA AAG CGA GCC TTG TTA GCG 336 Ile Leu Ser His Tyr Phe Ser Glu Ser Glu Lys Arg Ala Leu Leu Ala 100 105 110 TTA CCA GAG GCC TTG CAG CGA GAC CGC TTT TTT GAT TTG TGG GCG CTC 384 Leu Pro Glu Ala Leu Gln Arg Asp Arg Phe Phe Asp Leu Trp Ala Leu 115 120 125 AAG GAG TCT TAC ATT AAA GCG AAA GGA CTT GGG CTG GCA TTA TCG CTA 432 Lys Glu Ser Tyr Ile Lys Ala Lys Gly Leu Gly Leu Ala Leu Ser Leu 130 135 140 AAA TCT TTT GCG TTT GAC TTC TCT GCA CTG AGC GAA ACT TTT CTT GGA 480 Lys Ser Phe Ala Phe Asp Phe Ser Ala Leu Ser Glu Thr Phe Leu Gly 145 150 155 160 GTT AAT GCA CCT AAA AGC TTG AGC CAT TGT GTT GAT ATT TCC GAT GCT 528 Val Asn Ala Pro Lys Ser Leu Ser His Cys Val Asp Ile Ser Asp Ala 165 170 175 ATT GCG GAT CAC AAG GTT GAG CAT CAA CTT AAT CAG CGA CAG GTT TTG 576 Ile Ala Asp His Lys Val Glu His Gln Leu Asn Gln Arg Gln Val Leu 180 185 190 TTA AAA CAA GAT ATT GGT CTT GCT TTA CTA GAG TCG AGT TCT AAT AAG 624 Leu Lys Gln Asp Ile Gly Leu Ala Leu Leu Glu Ser Ser Ser Asn Lys 195 200 205 CCT AAC GCT GAG CCA CAA AAG TCT GGT TTA GGT TTG ATT GAG GCT AAA 672 Pro Asn Ala Glu Pro Gln Lys Ser Gly Leu Gly Leu Ile Glu Ala Lys 210 215 220 GAA CAG CAA ATG AAC GCT GCT GAT AAT TGG CAT TGT TTA CTG GGC CAT 720 Glu Gln Gln Met Asn Ala Ala Asp Asn Trp His Cys Leu Leu Gly His 225 230 235 240 CTT GAT GAT AGT TAT CGT TTT GCA CTG AGT ATT GGT CAG TGT CAG CAA 768 Leu Asp Asp Ser Tyr Arg Phe Ala Leu Ser Ile Gly Gln Cys Gln Gln 245 250 255 ATA AGT ATT GCA GCA GAA GAA GTG AAT TTT AAA GCT GTT GTT CGA GCT 816 Ile Ser Ile Ala Ala Glu Glu Val Asn Phe Lys Ala Val Val Arg Ala 260 265 270 TCA GCT AAG ACT AGC 831 Ser Ala Lys Thr Ser 275
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG GTA AGA GGC TAT TTG CGC GCT TTA TTG TCA CAA CAT AGT GAA ATA 48 Met Val Arg Gly Tyr Leu Arg Ala Leu Leu Ser Gln His Ser Glu Ile 5 10 15 CGC CCC AAT GAA TGG CGC TTT GAA TAT GGC GAC AAA GGT AAG CCT AGA 96 Arg Pro Asn Glu Trp Arg Phe Glu Tyr Gly Asp Lys Gly Lys Pro Arg 20 25 30 TTG AGT GAT GCG CAA TTT GCT CAA ACC GGG GTC CAC TTT AAT GTG AGT 144 Leu Ser Asp Ala Gln Phe Ala Gln Thr Gly Val His Phe Asn Val Ser 35 40 45 CAT AGT GGA GAT TGG CTA TTA GTA GGC ATT TGC ACT GCT GAT AAT AAA 192 His Ser Gly Asp Trp Leu Leu Val Gly Ile Cys Thr Ala Asp Asn Lys 50 55 60 GGC GCC AGT CAG GCA AGC AAG GAG GAA ACT GAC TCT GCT AGT ATT GAG 240 Gly Ala Ser Gln Ala Ser Lys Glu Glu Thr Asp Ser Ala Ser Ile Glu 65 70 75 80 TTT GGC GTC GAC ATT GAG CGT TGC CGT AAC AGC ACC AAT ATC CAC TCT 288 Phe Gly Val Asp Ile Glu Arg Cys Arg Asn Ser Thr Asn Ile His Ser 85 90 95 ATT CTT AGT CAT TAT TTC TCT GAA TCA GAA AAG CGA GCC TTG TTA GCG 336 Ile Leu Ser His Tyr Phe Ser Glu Ser Glu Lys Arg Ala Leu Leu Ala 100 105 110 TTA CCA GAG GCC TTG CAG CGA GAC CGC TTT TTT GAT TTG TGG GCG CTC 384 Leu Pro Glu Ala Leu Gln Arg Asp Arg Phe Phe Asp Leu Trp Ala Leu 115 120 125 AAG GAG TCT TAC ATT AAA GCG AAA GGA CTT GGG CTG GCA TTA TCG CTA 432 Lys Glu Ser Tyr Ile Lys Ala Lys Gly Leu Gly Leu Ala Leu Ser Leu 130 135 140 AAA TCT TTT GCG TTT GAC TTC TCT GCA CTG AGC GAA ACT TTT CTT GGA 480 Lys Ser Phe Ala Phe Asp Phe Ser Ala Leu Ser Glu Thr Phe Leu Gly 145 150 155 160 GTT AAT GCA CCT AAA AGC TTG AGC CAT TGT GTT GAT ATT TCC GAT GCT 528 Val Asn Ala Pro Lys Ser Leu Ser His Cys Val Asp Ile Ser Asp Ala 165 170 175 ATT GCG GAT CAC AAG GTT GAG CAT CAA CTT AAT CAG CGA CAG GTT TTG 576 Ile Ala Asp His Lys Val Glu His Gln Leu Asn Gln Arg Gln Val Leu 180 185 190 TTA AAA CAA GAT ATT GGT CTT GCT TTA CTA GAG TCG AGT TCT AAT AAG 624 Leu Lys Gln Asp Ile Gly Leu Ala Leu Leu Glu Ser Ser Ser Asn Lys 195 200 205 CCT AAC GCT GAG CCA CAA AAG TCT GGT TTA GGT TTG ATT GAG GCT AAA 672 Pro Asn Ala Glu Pro Gln Lys Ser Gly Leu Gly Leu Ile Glu Ala Lys 210 215 220 GAA CAG CAA ATG AAC GCT GCT GAT AAT TGG CAT TGT TTA CTG GGC CAT 720 Glu Gln Gln Met Asn Ala Ala Asp Asn Trp His Cys Leu Leu Gly His 225 230 235 240 CTT GAT GAT AGT TAT CGT TTT GCA CTG AGT ATT GGT CAG TGT CAG CAA 768 Leu Asp Asp Ser Tyr Arg Phe Ala Leu Ser Ile Gly Gln Cys Gln Gln 245 250 255 ATA AGT ATT GCA GCA GAA GAA GTG AAT TTT AAA GCT GTT GTT CGA GCT 816 Ile Ser Ile Ala Ala Glu Glu Val Asn Phe Lys Ala Val Val Arg Ala 260 265 270 TCA GCT AAG ACT AGC 831 Ser Ala Lys Thr Ser 275
【００５３】配列番号： ６ 配列の長さ：２７７ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Val Arg Gly Tyr Leu Arg Ala Leu Leu Ser Gln His Ser Glu Ile 5 10 15 Arg Pro Asn Glu Trp Arg Phe Glu Tyr Gly Asp Lys Gly Lys Pro Arg 20 25 30 Leu Ser Asp Ala Gln Phe Ala Gln Thr Gly Val His Phe Asn Val Ser 35 40 45 His Ser Gly Asp Trp Leu Leu Val Gly Ile Cys Thr Ala Asp Asn Lys 50 55 60 Gly Ala Ser Gln Ala Ser Lys Glu Glu Thr Asp Ser Ala Ser Ile Glu 65 70 75 80 Phe Gly Val Asp Ile Glu Arg Cys Arg Asn Ser Thr Asn Ile His Ser 85 90 95 Ile Leu Ser His Tyr Phe Ser Glu Ser Glu Lys Arg Ala Leu Leu Ala 100 105 110 Leu Pro Glu Ala Leu Gln Arg Asp Arg Phe Phe Asp Leu Trp Ala Leu 115 120 125 Lys Glu Ser Tyr Ile Lys Ala Lys Gly Leu Gly Leu Ala Leu Ser Leu 130 135 140 Lys Ser Phe Ala Phe Asp Phe Ser Ala Leu Ser Glu Thr Phe Leu Gly 145 150 155 160 Val Asn Ala Pro Lys Ser Leu Ser His Cys Val Asp Ile Ser Asp Ala 165 170 175 Ile Ala Asp His Lys Val Glu His Gln Leu Asn Gln Arg Gln Val Leu 180 185 190 Leu Lys Gln Asp Ile Gly Leu Ala Leu Leu Glu Ser Ser Ser Asn Lys 195 200 205 Pro Asn Ala Glu Pro Gln Lys Ser Gly Leu Gly Leu Ile Glu Ala Lys 210 215 220 Glu Gln Gln Met Asn Ala Ala Asp Asn Trp His Cys Leu Leu Gly His 225 230 235 240 Leu Asp Asp Ser Tyr Arg Phe Ala Leu Ser Ile Gly Gln Cys Gln Gln 245 250 255 Ile Ser Ile Ala Ala Glu Glu Val Asn Phe Lys Ala Val Val Arg Ala 260 265 270 Ser Ala Lys Thr Ser 275
【００５４】配列番号： ６ 配列の長さ：２９１０ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AGT ATG TTT TTA AAT TCA AAA CTT TCG CGC TCA GTC AAA CTT GCC 48 Met Ser Met Phe Leu Asn Ser Lys Leu Ser Arg Ser Val Lys Leu Ala 1 5 10 15 ATA TCC GCA GGC TTA ACA GCC TCG CTA GCT ATG CCT GTT TTT GCA GAA 96 Ile Ser Ala Gly Leu Thr Ala Ser Leu Ala Met Pro Val Phe Ala Glu 20 25 30 GAA ACT GCT GCT GAA GAA CAA ATA GAA AGA GTC GCA GTG ACC GGA TCG 144 Glu Thr Ala Ala Glu Glu Gln Ile Glu Arg Val Ala Val Thr Gly Ser 35 40 45 CGA ATC GCT AAA GCA GAG CTA ACT CAA CCA GCT CCA GTC GTC AGC CTT 192 Arg Ile Ala Lys Ala Glu Leu Thr Gln Pro Ala Pro Val Val Ser Leu 50 55 60 TCA GCC GAA GAA CTG ACA AAA TTT GGT AAT CAA GAT TTA GGT AGC GTA 240 Ser Ala Glu Glu Leu Thr Lys Phe Gly Asn Gln Asp Leu Gly Ser Val 65 70 75 80 CTA GCA GAA TTA CCT GCT ATT GGT GCA ACC AAC ACT ATT ATT GGT AAT 288 Leu Ala Glu Leu Pro Ala Ile Gly Ala Thr Asn Thr Ile Ile Gly Asn 85 90 95 AAC AAT AGC AAC TCA AGC GCA GGT GTT AGC TCA GCA GAC TTG CGT CGT 336 Asn Asn Ser Asn Ser Ser Ala Gly Val Ser Ser Ala Asp Leu Arg Arg 100 105 110 CTA GGT GCT AAC AGA ACC TTA GTA TTA GTC AAC GGT AAG CGC TAC GTT 384 Leu Gly Ala Asn Arg Thr Leu Val Leu Val Asn Gly Lys Arg Tyr Val 115 120 125 GCC GGC CAA CCG GGC TCA GCT GAG GTA GAT TTG TCA ACT ATA CCA ACT 432 Ala Gly Gln Pro Gly Ser Ala Glu Val Asp Leu Ser Thr Ile Pro Thr 130 135 140 AGC ATG ATC TCG CGA GTT GAG ATT GTA ACC GGC GGT GCT TCA GCA ATT 480 Ser Met Ile Ser Arg Val Glu Ile Val Thr Gly Gly Ala Ser Ala Ile 145 150 155 160 TAT GGT TCG GAC GCT GTA TCA GGT GTT ATC AAC GTT ATC CTT AAA GAA 528 Tyr Gly Ser Asp Ala Val Ser Gly Val Ile Asn Val Ile Leu Lys Glu 165 170 175 GAC TTT GAA GGC TTT GAG TTT AAC GCA CGT ACT AGC GGT TCT ACT GAA 576 Asp Phe Glu Gly Phe Glu Phe Asn Ala Arg Thr Ser Gly Ser Thr Glu 180 185 190 AGT GTA GGC ACT CAA GAG CAC TCT TTT GAC ATT TTG GGT GGT GCA AAC 624 Ser Val Gly Thr Gln Glu His Ser Phe Asp Ile Leu Gly Gly Ala Asn 195 200 205 GTT GCA GAT GGA CGT GGT AAT GTA ACC TTC TAC GCA GGT TAT GAA CGT 672 Val Ala Asp Gly Arg Gly Asn Val Thr Phe Tyr Ala Gly Tyr Glu Arg 210 215 220 ACA AAA GAA GTC ATG GCT ACC GAC ATT CGC CAA TTC GAT GCT TGG GGA 720 Thr Lys Glu Val Met Ala Thr Asp Ile Arg Gln Phe Asp Ala Trp Gly 225 230 235 240 ACA ATT AAA AAC GAA GCC GAT GGT GGT GAA GAT GAT GGT ATT CCA GAC 768 Thr Ile Lys Asn Glu Ala Asp Gly Gly Glu Asp Asp Gly Ile Pro Asp 245 250 255 AGA CTA CGT GTA CCA CGA GTT TAT TCT GAA ATG ATT AAT GCT ACC GGT 816 Arg Leu Arg Val Pro Arg Val Tyr Ser Glu Met Ile Asn Ala Thr Gly 260 265 270 GTT ATC AAT GCA TTT GGT GGT GGA ATT GGT CGC TCA ACC TTT GAC AGT 864 Val Ile Asn Ala Phe Gly Gly Gly Ile Gly Arg Ser Thr Phe Asp Ser 275 280 285 AAC GGC AAT CCT ATT GCA CAA CAA GAA CGT GAT GGG ACT AAC AGC TTT 912 Asn Gly Asn Pro Ile Ala Gln Gln Glu Arg Asp Gly Thr Asn Ser Phe 290 295 300 GCA TTT GGT TCA TTC CCT AAT GGC TGT GAC ACA TGT TTC AAC ACT GAA 960 Ala Phe Gly Ser Phe Pro Asn Gly Cys Asp Thr Cys Phe Asn Thr Glu 305 310 315 320 GCA TAC GAA AAC TAT ATT CCA GGG GTA GAA AGA ATA AAC GTT GGC TCA 1008 Ala Tyr Glu Asn Tyr Ile Pro Gly Val Glu Arg Ile Asn Val Gly Ser 325 330 335 TCA TTC AAC TTT GAT TTT ACC GAT AAC ATT CAA TTT TAC ACT GAC TTC 1056 Ser Phe Asn Phe Asp Phe Thr Asp Asn Ile Gln Phe Tyr Thr Asp Phe 340 345 350 AGA TAT GTA AAG TCA GAT ATT CAG CAA CAA TTT CAG CCT TCA TTC CGT 1104 Arg Tyr Val Lys Ser Asp Ile Gln Gln Gln Phe Gln Pro Ser Phe Arg 355 360 365 TTT GGT AAC ATT AAT ATC AAT GTT GAA GAT AAC GCC TTT TTG AAT GAC 1152 Phe Gly Asn Ile Asn Ile Asn Val Glu Asp Asn Ala Phe Leu Asn Asp 370 375 380 GAC TTG CGT CAG CAA ATG CTC GAT GCG GGT CAA ACC AAT GCT AGT TTT 1200 Asp Leu Arg Gln Gln Met Leu Asp Ala Gly Gln Thr Asn Ala Ser Phe 385 390 395 400 GCC AAG TTT TTT GAT GAA TTA GGA AAT CGC TCA GCA GAA AAT AAA CGC 1248 Ala Lys Phe Phe Asp Glu Leu Gly Asn Arg Ser Ala Glu Asn Lys Arg 405 410 415 GAA CTT TTC CGT TAC GTA GGT GGC TTT AAA GGT GGC TTT GAT ATT AGC 1296 Glu Leu Phe Arg Tyr Val Gly Gly Phe Lys Gly Gly Phe Asp Ile Ser 420 425 430 GAA ACC ATA TTT GAT TAC GAC CTT TAC TAT GTT TAT GGC GAG ACT AAT 1344 Glu Thr Ile Phe Asp Tyr Asp Leu Tyr Tyr Val Tyr Gly Glu Thr Asn 435 440 445 AAC CGT CGT AAA ACC CTT AAT GAC CTA ATT CCT GAT AAC TTT GTC GCA 1392 Asn Arg Arg Lys Thr Leu Asn Asp Leu Ile Pro Asp Asn Phe Val Ala 450 455 460 GCT GTC GAC TCT GTT ATT GAT CCT GAT ACT GGC TTA GCA GCG TGT CGC 1440 Ala Val Asp Ser Val Ile Asp Pro Asp Thr Gly Leu Ala Ala Cys Arg 465 470 475 480 TCA CAA GTA GCA AGC GCT CAA GGC GAT GAC TAT ACA GAT CCC GCG TCT 1488 Ser Gln Val Ala Ser Ala Gln Gly Asp Asp Tyr Thr Asp Pro Ala Ser 485 490 495 GTA AAT GGT AGC GAC TGT GTT GCT TAT AAC CCA TTT GGC ATG GGT CAA 1536 Val Asn Gly Ser Asp Cys Val Ala Tyr Asn Pro Phe Gly Met Gly Gln 500 505 510 GCT TCA GCA GAA GCC CGC GAC TGG GTT TCT GCT GAT GTG ACT CGT GAA 1584 Ala Ser Ala Glu Ala Arg Asp Trp Val Ser Ala Asp Val Thr Arg Glu 515 520 525 GAC AAA ATA ACT CAA CAA GTG ATT GGT GGT ACT CTC GGT ACC GAT TCT 1632 Asp Lys Ile Thr Gln Gln Val Ile Gly Gly Thr Leu Gly Thr Asp Ser 530 535 540 GAA GAA CTA TTT GAG CTT CAA GGT GGT GCA ATC GCT ATG GTT GTT GGT 1680 Glu Glu Leu Phe Glu Leu Gln Gly Gly Ala Ile Ala Met Val Val Gly 545 550 555 560 TTT GAA TAC CGT GAA GAA ACG TCT GGT TCA ACA ACC GAT GAA TTT ACT 1728 Phe Glu Tyr Arg Glu Glu Thr Ser Gly Ser Thr Thr Asp Glu Phe Thr 565 570 575 AAA GCA GGT TTC TTG ACA AGC GCT GCA ACG CCA GAT TCT TAT GGC GAA 1776 Lys Ala Gly Phe Leu Thr Ser Ala Ala Thr Pro Asp Ser Tyr Gly Glu 580 585 590 TAC GAC GTG ACT GAG TAT TTT GTT GAG GTG AAC ATC CCA GTA CTA AAA 1824 Tyr Asp Val Thr Glu Tyr Phe Val Glu Val Asn Ile Pro Val Leu Lys 595 600 605 GAA TTA CCT TTT GCA CAT GAG TTG AGC TTT GAC GGT GCA TAC CGT AAT 1872 Glu Leu Pro Phe Ala His Glu Leu Ser Phe Asp Gly Ala Tyr Arg Asn 610 615 620 GCT GAT TAC TCA CAT GCC GGT AAG ACT GAA GCA TGG AAA GCT GGT ATG 1920 Ala Asp Tyr Ser His Ala Gly Lys Thr Glu Ala Trp Lys Ala Gly Met 625 630 635 640 TTC TAC TCA CCA TTA GAG CAA CTT GCA TTA CGT GGT ACG GTA GGT GAA 1968 Phe Tyr Ser Pro Leu Glu Gln Leu Ala Leu Arg Gly Thr Val Gly Glu 645 650 655 GCA GTA CGA GCA CCA AAC ATT GCA GAA GCC TTT AGT CCA CGC TCT CCT 2016 Ala Val Arg Ala Pro Asn Ile Ala Glu Ala Phe Ser Pro Arg Ser Pro 660 665 670 GGT TTT GGC CGC GTT TCA GAT CCA TGT GAT GCA GAT AAC ATT AAT GAC 2064 Gly Phe Gly Arg Val Ser Asp Pro Cys Asp Ala Asp Asn Ile Asn Asp 675 680 685 GAT CCG GAT CGC GTG TCA AAC TGT GCA GCA TTG GGG ATC CCT CCA GGA 2112 Asp Pro Asp Arg Val Ser Asn Cys Ala Ala Leu Gly Ile Pro Pro Gly 690 695 700 TTC CAA GCT AAT GAT AAC GTC AGT GTA GAT ACC TTA TCT GGT GGT AAC 2160 Phe Gln Ala Asn Asp Asn Val Ser Val Asp Thr Leu Ser Gly Gly Asn 705 710 715 720 CCA GAT CTA AAA CCT GAA ACA TCA ACA TCC TTT ACA GGT GGT CTT GTT 2208 Pro Asp Leu Lys Pro Glu Thr Ser Thr Ser Phe Thr Gly Gly Leu Val 725 730 735 TGG ACA CCA ACG TTT GCT GAC AAT CTA TCA TTC ACT GTC GAT TAT TAT 2256 Trp Thr Pro Thr Phe Ala Asp Asn Leu Ser Phe Thr Val Asp Tyr Tyr 740 745 750 GAT ATT CAA ATT GAG GAT GCT ATT TTG TCA GTA GCC ACC CAG ACT GTG 2304 Asp Ile Gln Ile Glu Asp Ala Ile Leu Ser Val Ala Thr Gln Thr Val 755 760 765 GCT GAT AAC TGT GTT GAC TCA ACT GGC GGA CCT GAC ACC GAC TTC TGT 2352 Ala Asp Asn Cys Val Asp Ser Thr Gly Gly Pro Asp Thr Asp Phe Cys 770 775 780 AGT CAA GTT GAT CGT AAT CCA ACG ACC TAT GAT ATT GAA CTT GTT CGC 2400 Ser Gln Val Asp Arg Asn Pro Thr Thr Tyr Asp Ile Glu Leu Val Arg 785 790 795 800 TCT GGT TAT CTA AAT GCC GCG GCA TTG AAT ACC AAA GGT ATT GAA TTT 2448 Ser Gly Tyr Leu Asn Ala Ala Ala Leu Asn Thr Lys Gly Ile Glu Phe 805 810 815 CAA GCT GCA TAC TCA TTA GAT CTA GAG TCT TTC AAC GCG CCT GGT GAA 2496 Gln Ala Ala Tyr Ser Leu Asp Leu Glu Ser Phe Asn Ala Pro Gly Glu 820 825 830 CTA CGC TTC AAC CTA TTG GGG AAC CAA TTA CTT GAA CTA GAA CGT CTT 2544 Leu Arg Phe Asn Leu Leu Gly Asn Gln Leu Leu Glu Leu Glu Arg Leu 835 840 845 GAA TTC CAA AAT CGT CCT GAT GAG ATT AAT GAT GAA AAA GGC GAA GTA 2592 Glu Phe Gln Asn Arg Pro Asp Glu Ile Asn Asp Glu Lys Gly Glu Val 850 855 860 GGT GAT CCA GAG CTG CAG TTC CGC CTA GGC ATC GAT TAC CGT CTA GAT 2640 Gly Asp Pro Glu Leu Gln Phe Arg Leu Gly Ile Asp Tyr Arg Leu Asp 865 870 875 880 GAT CTA AGT GTT AGC TGG AAC ACG CGT TAT ATT GAT AGC GTA GTA ACT 2688 Asp Leu Ser Val Ser Trp Asn Thr Arg Tyr Ile Asp Ser Val Val Thr 885 890 895 TAT GAT GTC TCT GAA AAT GGT GGC TCT CCT GAA GAT TTA TAT CCA GGC 2736 Tyr Asp Val Ser Glu Asn Gly Gly Ser Pro Glu Asp Leu Tyr Pro Gly 900 905 910 CAC ATA GGC TCA ATG ACA ACT CAT GAC TTG AGC GCT ACA TAC TAC ATC 2784 His Ile Gly Ser Met Thr Thr His Asp Leu Ser Ala Thr Tyr Tyr Ile 915 920 925 AAT GAG AAC TTC ATG ATT AAC GGT GGT GTA CGT AAC CTA TTT GAC GCA 2832 Asn Glu Asn Phe Met Ile Asn Gly Gly Val Arg Asn Leu Phe Asp Ala 930 935 940 CTT CCA CCT GGA TAC ACT AAC GAT GCG CTA TAT GAT CTA GTT GGT CGC 2880 Leu Pro Pro Gly Tyr Thr Asn Asp Ala Leu Tyr Asp Leu Val Gly Arg 945 950 955 960 CGT GCA TTC CTA GGT ATT AAG GTA ATG ATG 2910 Arg Ala Phe Leu Gly Ile Lys Val Met Met 965 970
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AGT ATG TTT TTA AAT TCA AAA CTT TCG CGC TCA GTC AAA CTT GCC 48 Met Ser Met Phe Leu Asn Ser Lys Leu Ser Arg Ser Val Lys Leu Ala 1 5 10 15 ATA TCC GCA GGC TTA ACA GCC TCG CTA GCT ATG CCT GTT TTT GCA GAA 96 Ile Ser Ala Gly Leu Thr Ala Ser Leu Ala Met Pro Val Phe Ala Glu 20 25 30 GAA ACT GCT GCT GAA GAA CAA ATA GAA AGA GTC GCA GTG ACC GGA TCG 144 Glu Thr Ala Ala Glu Glu Gln Ile Glu Arg Val Ala Val Thr Gly Ser 35 40 45 CGA ATC GCT AAA GCA GAG CTA ACT CAA CCA GCT CCA GTC GTC AGC CTT 192 Arg Ile Ala Lys Ala Glu Leu Thr Gln Pro Ala Pro Val Val Ser Leu 50 55 60 TCA GCC GAA GAA CTG ACA AAA TTT GGT AAT CAA GAT TTA GGT AGC GTA 240 Ser Ala Glu Glu Leu Thr Lys Phe Gly Asn Gln Asp Leu Gly Ser Val 65 70 75 80 CTA GCA GAA TTA CCT GCT ATT GGT GCA ACC AAC ACT ATT ATT GGT AAT 288 Leu Ala Glu Leu Pro Ala Ile Gly Ala Thr Asn Thr Ile Ile Gly Asn 85 90 95 AAC AAT AGC AAC TCA AGC GCA GGT GTT AGC TCA GCA GAC TTG CGT CGT 336 Asn Asn Ser Asn Ser Ser Ala Gly Val Ser Ser Ala Asp Leu Arg Arg 100 105 110 CTA GGT GCT AAC AGA ACC TTA GTA TTA GTC AAC GGT AAG CGC TAC GTT 384 Leu Gly Ala Asn Arg Thr Leu Val Leu Val Asn Gly Lys Arg Tyr Val 115 120 125 GCC GGC CAA CCG GGC TCA GCT GAG GTA GAT TTG TCA ACT ATA CCA ACT 432 Ala Gly Gln Pro Gly Ser Ala Glu Val Asp Leu Ser Thr Ile Pro Thr 130 135 140 AGC ATG ATC TCG CGA GTT GAG ATT GTA ACC GGC GGT GCT TCA GCA ATT 480 Ser Met Ile Ser Arg Val Glu Ile Val Thr Gly Gly Ala Ser Ala Ile 145 150 155 160 TAT GGT TCG GAC GCT GTA TCA GGT GTT ATC AAC GTT ATC CTT AAA GAA 528 Tyr Gly Ser Asp Ala Val Ser Gly Val Ile Asn Val Ile Leu Lys Glu 165 170 175 GAC TTT GAA GGC TTT GAG TTT AAC GCA CGT ACT AGC GGT TCT ACT GAA 576 Asp Phe Glu Gly Phe Glu Phe Asn Ala Arg Thr Ser Gly Ser Thr Glu 180 185 190 AGT GTA GGC ACT CAA GAG CAC TCT TTT GAC ATT TTG GGT GGT GCA AAC 624 Ser Val Gly Thr Gln Glu His Ser Phe Asp Ile Leu Gly Gly Ala Asn 195 200 205 GTT GCA GAT GGA CGT GGT AAT GTA ACC TTC TAC GCA GGT TAT GAA CGT 672 Val Ala Asp Gly Arg Gly Asn Val Thr Phe Tyr Ala Gly Tyr Glu Arg 210 215 220 ACA AAA GAA GTC ATG GCT ACC GAC ATT CGC CAA TTC GAT GCT TGG GGA 720 Thr Lys Glu Val Met Ala Thr Asp Ile Arg Gln Phe Asp Ala Trp Gly 225 230 235 240 ACA ATT AAA AAC GAA GCC GAT GGT GGT GAA GAT GAT GGT ATT CCA GAC 768 Thr Ile Lys Asn Glu Ala Asp Gly Gly Glu Asp Asp Gly Ile Pro Asp 245 250 255 AGA CTA CGT GTA CCA CGA GTT TAT TCT GAA ATG ATT AAT GCT ACC GGT 816 Arg Leu Arg Val Pro Arg Val Tyr Ser Glu Met Ile Asn Ala Thr Gly 260 265 270 GTT ATC AAT GCA TTT GGT GGT GGA ATT GGT CGC TCA ACC TTT GAC AGT 864 Val Ile Asn Ala Phe Gly Gly Gly Ile Gly Arg Ser Thr Phe Asp Ser 275 280 285 AAC GGC AAT CCT ATT GCA CAA CAA GAA CGT GAT GGG ACT AAC AGC TTT 912 Asn Gly Asn Pro Ile Ala Gln Gln Glu Arg Asp Gly Thr Asn Ser Phe 290 295 300 GCA TTT GGT TCA TTC CCT AAT GGC TGT GAC ACA TGT TTC AAC ACT GAA 960 Ala Phe Gly Ser Phe Pro Asn Gly Cys Asp Thr Cys Phe Asn Thr Glu 305 310 315 320 GCA TAC GAA AAC TAT ATT CCA GGG GTA GAA AGA ATA AAC GTT GGC TCA 1008 Ala Tyr Glu Asn Tyr Ile Pro Gly Val Glu Arg Ile Asn Val Gly Ser 325 330 335 TCA TTC AAC TTT GAT TTT ACC GAT AAC ATT CAA TTT TAC ACT GAC TTC 1056 Ser Phe Asn Phe Asp Phe Thr Asp Asn Ile Gln Phe Tyr Thr Asp Phe 340 345 350 AGA TAT GTA AAG TCA GAT ATT CAG CAA CAA TTT CAG CCT TCA TTC CGT 1104 Arg Tyr Val Lys Ser Asp Ile Gln Gln Gln Phe Gln Pro Ser Phe Arg 355 360 365 TTT GGT AAC ATT AAT ATC AAT GTT GAA GAT AAC GCC TTT TTG AAT GAC 1152 Phe Gly Asn Ile Asn Ile Asn Val Glu Asp Asn Ala Phe Leu Asn Asp 370 375 380 GAC TTG CGT CAG CAA ATG CTC GAT GCG GGT CAA ACC AAT GCT AGT TTT 1200 Asp Leu Arg Gln Gln Met Leu Asp Ala Gly Gln Thr Asn Ala Ser Phe 385 390 395 400 GCC AAG TTT TTT GAT GAA TTA GGA AAT CGC TCA GCA GAA AAT AAA CGC 1248 Ala Lys Phe Phe Asp Glu Leu Gly Asn Arg Ser Ala Glu Asn Lys Arg 405 410 415 GAA CTT TTC CGT TAC GTA GGT GGC TTT AAA GGT GGC TTT GAT ATT AGC 1296 Glu Leu Phe Arg Tyr Val Gly Gly Phe Lys Gly Gly Phe Asp Ile Ser 420 425 430 GAA ACC ATA TTT GAT TAC GAC CTT TAC TAT GTT TAT GGC GAG ACT AAT 1344 Glu Thr Ile Phe Asp Tyr Asp Leu Tyr Tyr Val Tyr Gly Glu Thr Asn 435 440 445 AAC CGT CGT AAA ACC CTT AAT GAC CTA ATT CCT GAT AAC TTT GTC GCA 1392 Asn Arg Arg Lys Thr Leu Asn Asp Leu Ile Pro Asp Asn Phe Val Ala 450 455 460 GCT GTC GAC TCT GTT ATT GAT CCT GAT ACT GGC TTA GCA GCG TGT CGC 1440 Ala Val Asp Ser Val Ile Asp Pro Asp Thr Gly Leu Ala Ala Cys Arg 465 470 475 480 TCA CAA GTA GCA AGC GCT CAA GGC GAT GAC TAT ACA GAT CCC GCG TCT 1488 Ser Gln Val Ala Ser Ala Gln Gly Asp Asp Tyr Thr Asp Pro Ala Ser 485 490 495 GTA AAT GGT AGC GAC TGT GTT GCT TAT AAC CCA TTT GGC ATG GGT CAA 1536 Val Asn Gly Ser Asp Cys Val Ala Tyr Asn Pro Phe Gly Met Gly Gln 500 505 510 GCT TCA GCA GAA GCC CGC GAC TGG GTT TCT GCT GAT GTG ACT CGT GAA 1584 Ala Ser Ala Glu Ala Arg Asp Trp Val Ser Ala Asp Val Thr Arg Glu 515 520 525 GAC AAA ATA ACT CAA CAA GTG ATT GGT GGT ACT CTC GGT ACC GAT TCT 1632 Asp Lys Ile Thr Gln Gln Val Ile Gly Gly Thr Leu Gly Thr Asp Ser 530 535 540 GAA GAA CTA TTT GAG CTT CAA GGT GGT GCA ATC GCT ATG GTT GTT GGT 1680 Glu Glu Leu Phe Glu Leu Gln Gly Gly Ala Ile Ala Met Val Val Gly 545 550 555 560 TTT GAA TAC CGT GAA GAA ACG TCT GGT TCA ACA ACC GAT GAA TTT ACT 1728 Phe Glu Tyr Arg Glu Glu Thr Ser Gly Ser Thr Thr Asp Glu Phe Thr 565 570 575 AAA GCA GGT TTC TTG ACA AGC GCT GCA ACG CCA GAT TCT TAT GGC GAA 1776 Lys Ala Gly Phe Leu Thr Ser Ala Ala Thr Pro Asp Ser Tyr Gly Glu 580 585 590 TAC GAC GTG ACT GAG TAT TTT GTT GAG GTG AAC ATC CCA GTA CTA AAA 1824 Tyr Asp Val Thr Glu Tyr Phe Val Glu Val Asn Ile Pro Val Leu Lys 595 600 605 GAA TTA CCT TTT GCA CAT GAG TTG AGC TTT GAC GGT GCA TAC CGT AAT 1872 Glu Leu Pro Phe Ala His Glu Leu Ser Phe Asp Gly Ala Tyr Arg Asn 610 615 620 GCT GAT TAC TCA CAT GCC GGT AAG ACT GAA GCA TGG AAA GCT GGT ATG 1920 Ala Asp Tyr Ser His Ala Gly Lys Thr Glu Ala Trp Lys Ala Gly Met 625 630 635 640 TTC TAC TCA CCA TTA GAG CAA CTT GCA TTA CGT GGT ACG GTA GGT GAA 1968 Phe Tyr Ser Pro Leu Glu Gln Leu Ala Leu Arg Gly Thr Val Gly Glu 645 650 655 GCA GTA CGA GCA CCA AAC ATT GCA GAA GCC TTT AGT CCA CGC TCT CCT 2016 Ala Val Arg Ala Pro Asn Ile Ala Glu Ala Phe Ser Pro Arg Ser Pro 660 665 670 GGT TTT GGC CGC GTT TCA GAT CCA TGT GAT GCA GAT AAC ATT AAT GAC 2064 Gly Phe Gly Arg Val Ser Asp Pro Cys Asp Ala Asp Asn Ile Asn Asp 675 680 685 GAT CCG GAT CGC GTG TCA AAC TGT GCA GCA TTG GGG ATC CCT CCA GGA 2112 Asp Pro Asp Arg Val Ser Asn Cys Ala Ala Leu Gly Ile Pro Pro Gly 690 695 700 TTC CAA GCT AAT GAT AAC GTC AGT GTA GAT ACC TTA TCT GGT GGT AAC 2160 Phe Gln Ala Asn Asp Asn Val Ser Val Asp Thr Leu Ser Gly Gly Asn 705 710 715 720 CCA GAT CTA AAA CCT GAA ACA TCA ACA TCC TTT ACA GGT GGT CTT GTT 2208 Pro Asp Leu Lys Pro Glu Thr Ser Thr Ser Phe Thr Gly Gly Leu Val 725 730 735 TGG ACA CCA ACG TTT GCT GAC AAT CTA TCA TTC ACT GTC GAT TAT TAT 2256 Trp Thr Pro Thr Phe Ala Asp Asn Leu Ser Phe Thr Val Asp Tyr Tyr 740 745 750 GAT ATT CAA ATT GAG GAT GCT ATT TTG TCA GTA GCC ACC CAG ACT GTG 2304 Asp Ile Gln Ile Glu Asp Ala Ile Leu Ser Val Ala Thr Gln Thr Val 755 760 765 GCT GAT AAC TGT GTT GAC TCA ACT GGC GGA CCT GAC ACC GAC TTC TGT 2352 Ala Asp Asn Cys Val Asp Ser Thr Gly Gly Pro Asp Thr Asp Phe Cys 770 775 780 AGT CAA GTT GAT CGT AAT CCA ACG ACC TAT GAT ATT GAA CTT GTT CGC 2400 Ser Gln Val Asp Arg Asn Pro Thr Thr Tyr Asp Ile Glu Leu Val Arg 785 790 795 800 TCT GGT TAT CTA AAT GCC GCG GCA TTG AAT ACC AAA GGT ATT GAA TTT 2448 Ser Gly Tyr Leu Asn Ala Ala Ala Leu Asn Thr Lys Gly Ile Glu Phe 805 810 815 CAA GCT GCA TAC TCA TTA GAT CTA GAG TCT TTC AAC GCG CCT GGT GAA 2496 Gln Ala Ala Tyr Ser Leu Asp Leu Glu Ser Phe Asn Ala Pro Gly Glu 820 825 830 CTA CGC TTC AAC CTA TTG GGG AAC CAA TTA CTT GAA CTA GAA CGT CTT 2544 Leu Arg Phe Asn Leu Leu Gly Asn Gln Leu Leu Glu Leu Glu Arg Leu 835 840 845 GAA TTC CAA AAT CGT CCT GAT GAG ATT AAT GAT GAA AAA GGC GAA GTA 2592 Glu Phe Gln Asn Arg Pro Asp Glu Ile Asn Asp Glu Lys Gly Glu Val 850 855 860 GGT GAT CCA GAG CTG CAG TTC CGC CTA GGC ATC GAT TAC CGT CTA GAT 2640 Gly Asp Pro Glu Leu Gln Phe Arg Leu Gly Ile Asp Tyr Arg Leu Asp 865 870 875 880 GAT CTA AGT GTT AGC TGG AAC ACG CGT TAT ATT GAT AGC GTA GTA ACT 2688 Asp Leu Ser Val Ser Trp Asn Thr Arg Tyr Ile Asp Ser Val Val Thr 885 890 895 TAT GAT GTC TCT GAA AAT GGT GGC TCT CCT GAA GAT TTA TAT CCA GGC 2736 Tyr Asp Val Ser Glu Asn Gly Gly Ser Pro Glu Asp Leu Tyr Pro Gly 900 905 910 CAC ATA GGC TCA ATG ACA ACT CAT GAC TTG AGC GCT ACA TAC TAC ATC 2784 His Ile Gly Ser Met Thr Thr His Asp Leu Ser Ala Thr Tyr Tyr Ile 915 920 925 AAT GAG AAC TTC ATG ATT AAC GGT GGT GTA CGT AAC CTA TTT GAC GCA 2832 Asn Glu Asn Phe Met Ile Asn Gly Gly Val Arg Asn Leu Phe Asp Ala 930 935 940 CTT CCA CCT GGA TAC ACT AAC GAT GCG CTA TAT GAT CTA GTT GGT CGC 2880 Leu Pro Pro Gly Tyr Thr Asn Asp Ala Leu Tyr Asp Leu Val Gly Arg 945 950 955 960 CGT GCA TTC CTA GGT ATT AAG GTA ATG ATG 2910 Arg Ala Phe Leu Gly Ile Lys Val Met Met 965 970
【００５５】配列番号： ７ 配列の長さ：９７０ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Ser Met Phe Leu Asn Ser Lys Leu Ser Arg Ser Val Lys Leu Ala 1 5 10 15 Ile Ser Ala Gly Leu Thr Ala Ser Leu Ala Met Pro Val Phe Ala Glu 20 25 30 Glu Thr Ala Ala Glu Glu Gln Ile Glu Arg Val Ala Val Thr Gly Ser 35 40 45 Arg Ile Ala Lys Ala Glu Leu Thr Gln Pro Ala Pro Val Val Ser Leu 50 55 60 Ser Ala Glu Glu Leu Thr Lys Phe Gly Asn Gln Asp Leu Gly Ser Val 65 70 75 80 Leu Ala Glu Leu Pro Ala Ile Gly Ala Thr Asn Thr Ile Ile Gly Asn 85 90 95 Asn Asn Ser Asn Ser Ser Ala Gly Val Ser Ser Ala Asp Leu Arg Arg 100 105 110 Leu Gly Ala Asn Arg Thr Leu Val Leu Val Asn Gly Lys Arg Tyr Val 115 120 125 Ala Gly Gln Pro Gly Ser Ala Glu Val Asp Leu Ser Thr Ile Pro Thr 130 135 140 Ser Met Ile Ser Arg Val Glu Ile Val Thr Gly Gly Ala Ser Ala Ile 145 150 155 160 Tyr Gly Ser Asp Ala Val Ser Gly Val Ile Asn Val Ile Leu Lys Glu 165 170 175 Asp Phe Glu Gly Phe Glu Phe Asn Ala Arg Thr Ser Gly Ser Thr Glu 180 185 190 Ser Val Gly Thr Gln Glu His Ser Phe Asp Ile Leu Gly Gly Ala Asn 195 200 205 Val Ala Asp Gly Arg Gly Asn Val Thr Phe Tyr Ala Gly Tyr Glu Arg 210 215 220 Thr Lys Glu Val Met Ala Thr Asp Ile Arg Gln Phe Asp Ala Trp Gly 225 230 235 240 Thr Ile Lys Asn Glu Ala Asp Gly Gly Glu Asp Asp Gly Ile Pro Asp 245 250 255 Arg Leu Arg Val Pro Arg Val Tyr Ser Glu Met Ile Asn Ala Thr Gly 260 265 270 Val Ile Asn Ala Phe Gly Gly Gly Ile Gly Arg Ser Thr Phe Asp Ser 275 280 285 Asn Gly Asn Pro Ile Ala Gln Gln Glu Arg Asp Gly Thr Asn Ser Phe 290 295 300 Ala Phe Gly Ser Phe Pro Asn Gly Cys Asp Thr Cys Phe Asn Thr Glu 305 310 315 320 Ala Tyr Glu Asn Tyr Ile Pro Gly Val Glu Arg Ile Asn Val Gly Ser 325 330 335 Ser Phe Asn Phe Asp Phe Thr Asp Asn Ile Gln Phe Tyr Thr Asp Phe 340 345 350 Arg Tyr Val Lys Ser Asp Ile Gln Gln Gln Phe Gln Pro Ser Phe Arg 355 360 365 Phe Gly Asn Ile Asn Ile Asn Val Glu Asp Asn Ala Phe Leu Asn Asp 370 375 380 Asp Leu Arg Gln Gln Met Leu Asp Ala Gly Gln Thr Asn Ala Ser Phe 385 390 395 400 Ala Lys Phe Phe Asp Glu Leu Gly Asn Arg Ser Ala Glu Asn Lys Arg 405 410 415 Glu Leu Phe Arg Tyr Val Gly Gly Phe Lys Gly Gly Phe Asp Ile Ser 420 425 430 Glu Thr Ile Phe Asp Tyr Asp Leu Tyr Tyr Val Tyr Gly Glu Thr Asn 435 440 445 Asn Arg Arg Lys Thr Leu Asn Asp Leu Ile Pro Asp Asn Phe Val Ala 450 455 460 Ala Val Asp Ser Val Ile Asp Pro Asp Thr Gly Leu Ala Ala Cys Arg 465 470 475 480 Ser Gln Val Ala Ser Ala Gln Gly Asp Asp Tyr Thr Asp Pro Ala Ser 485 490 495 Val Asn Gly Ser Asp Cys Val Ala Tyr Asn Pro Phe Gly Met Gly Gln 500 505 510 Ala Ser Ala Glu Ala Arg Asp Trp Val Ser Ala Asp Val Thr Arg Glu 515 520 525 Asp Lys Ile Thr Gln Gln Val Ile Gly Gly Thr Leu Gly Thr Asp Ser 530 535 540 Glu Glu Leu Phe Glu Leu Gln Gly Gly Ala Ile Ala Met Val Val Gly 545 550 555 560 Phe Glu Tyr Arg Glu Glu Thr Ser Gly Ser Thr Thr Asp Glu Phe Thr 565 570 575 Lys Ala Gly Phe Leu Thr Ser Ala Ala Thr Pro Asp Ser Tyr Gly Glu 580 585 590 Tyr Asp Val Thr Glu Tyr Phe Val Glu Val Asn Ile Pro Val Leu Lys 595 600 605 Glu Leu Pro Phe Ala His Glu Leu Ser Phe Asp Gly Ala Tyr Arg Asn 610 615 620 Ala Asp Tyr Ser His Ala Gly Lys Thr Glu Ala Trp Lys Ala Gly Met 625 630 635 640 Phe Tyr Ser Pro Leu Glu Gln Leu Ala Leu Arg Gly Thr Val Gly Glu 645 650 655 Ala Val Arg Ala Pro Asn Ile Ala Glu Ala Phe Ser Pro Arg Ser Pro 660 665 670 Gly Phe Gly Arg Val Ser Asp Pro Cys Asp Ala Asp Asn Ile Asn Asp 675 680 685 Asp Pro Asp Arg Val Ser Asn Cys Ala Ala Leu Gly Ile Pro Pro Gly 690 695 700 Phe Gln Ala Asn Asp Asn Val Ser Val Asp Thr Leu Ser Gly Gly Asn 705 710 715 720 Pro Asp Leu Lys Pro Glu Thr Ser Thr Ser Phe Thr Gly Gly Leu Val 725 730 735 Trp Thr Pro Thr Phe Ala Asp Asn Leu Ser Phe Thr Val Asp Tyr Tyr 740 745 750 Asp Ile Gln Ile Glu Asp Ala Ile Leu Ser Val Ala Thr Gln Thr Val 755 760 765 Ala Asp Asn Cys Val Asp Ser Thr Gly Gly Pro Asp Thr Asp Phe Cys 770 775 780 Ser Gln Val Asp Arg Asn Pro Thr Thr Tyr Asp Ile Glu Leu Val Arg 785 790 795 800 Ser Gly Tyr Leu Asn Ala Ala Ala Leu Asn Thr Lys Gly Ile Glu Phe 805 810 815 Gln Ala Ala Tyr Ser Leu Asp Leu Glu Ser Phe Asn Ala Pro Gly Glu 820 825 830 Leu Arg Phe Asn Leu Leu Gly Asn Gln Leu Leu Glu Leu Glu Arg Leu 835 840 845 Glu Phe Gln Asn Arg Pro Asp Glu Ile Asn Asp Glu Lys Gly Glu Val 850 855 860 Gly Asp Pro Glu Leu Gln Phe Arg Leu Gly Ile Asp Tyr Arg Leu Asp 865 870 875 880 Asp Leu Ser Val Ser Trp Asn Thr Arg Tyr Ile Asp Ser Val Val Thr 885 890 895 Tyr Asp Val Ser Glu Asn Gly Gly Ser Pro Glu Asp Leu Tyr Pro Gly 900 905 910 His Ile Gly Ser Met Thr Thr His Asp Leu Ser Ala Thr Tyr Tyr Ile 915 920 925 Asn Glu Asn Phe Met Ile Asn Gly Gly Val Arg Asn Leu Phe Asp Ala 930 935 940 Leu Pro Pro Gly Tyr Thr Asn Asp Ala Leu Tyr Asp Leu Val Gly Arg 945 950 955 960 Arg Ala Phe Leu Gly Ile Lys Val Met Met 965 970
【００５６】配列番号： ８ 配列の長さ：８６４ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG GCA AAA ATA AAT AGT GAA CAC TTG GAT GAA GCT ACT ATT ACT TCG 48 Met Ala Lys Ile Asn Ser Glu His Leu Asp Glu Ala Thr Ile Thr Ser 1 5 10 15 AAT AAG TGT ACG CAA ACA GAG ACT GAG GCT CGG CAT AGA AAT GCC ACT 96 Asn Lys Cys Thr Gln Thr Glu Thr Glu Ala Arg His Arg Asn Ala Thr 20 25 30 ACA ACA CCT GAG ATG CGC CGA TTC ATA CAA GAG TCG GAT CTC AGT GTT 144 Thr Thr Pro Glu Met Arg Arg Phe Ile Gln Glu Ser Asp Leu Ser Val 35 40 45 AGC CAA CTG TCT AAA ATA TTA AAT ATC AGT GAA GCT ACC GTA CGT AAG 192 Ser Gln Leu Ser Lys Ile Leu Asn Ile Ser Glu Ala Thr Val Arg Lys 50 55 60 TGG CGC AAG CGT GAC TCT GTC GAA AAC TGT CCT AAT ACC CCG CAC CAT 240 Trp Arg Lys Arg Asp Ser Val Glu Asn Cys Pro Asn Thr Pro His His 65 70 75 80 CTC AAT ACC ACG CTA ACC CCT TTG CAA GAA TAT GTG GTT GTG GGC CTG 288 Leu Asn Thr Thr Leu Thr Pro Leu Gln Glu Tyr Val Val Val Gly Leu 85 90 95 CGT TAT CAA TTG AAA ATG CCA TTA GAC AGA TTG CTC AAA GCA ACC CAA 336 Arg Tyr Gln Leu Lys Met Pro Leu Asp Arg Leu Leu Lys Ala Thr Gln 100 105 110 GAG TTT ATC AAT CCA AAC GTG TCG CGC TCA GGT TTA GCA AGA TGT TTG 384 Glu Phe Ile Asn Pro Asn Val Ser Arg Ser Gly Leu Ala Arg Cys Leu 115 120 125 AAG CGT TAT GGC GTT TCA CGG GTG AGT GAT ATC CAA AGC CCA CAC GTA 432 Lys Arg Tyr Gly Val Ser Arg Val Ser Asp Ile Gln Ser Pro His Val 130 135 140 CCA ATG CGC TAC TTT AAT CAA ATT CCA GTC ACT CAA GGC AGC GAT GTG 480 Pro Met Arg Tyr Phe Asn Gln Ile Pro Val Thr Gln Gly Ser Asp Val 145 150 155 160 CAA ACC TAC ACC CTG CAC TAT GAA ACG CTG GCA AAA ACC TTA GCC TTA 528 Gln Thr Tyr Thr Leu His Tyr Glu Thr Leu Ala Lys Thr Leu Ala Leu 165 170 175 CCT AGT ACC GAT GGT GAC AAT GTG GTG CAA GTG GTG TCT CTC ACC ATT 576 Pro Ser Thr Asp Gly Asp Asn Val Val Gln Val Val Ser Leu Thr Ile 180 185 190 CCA CCA AAG TTA ACC GAA GAA GCA CCC AGT TCA ATT TTG CTC GGC ATT 624 Pro Pro Lys Leu Thr Glu Glu Ala Pro Ser Ser Ile Leu Leu Gly Ile 195 200 205 GAT CCT CAT AGC GAC TGG ATC TAT CTC GAC ATA TAC CAA GAT GGC AAT 672 Asp Pro His Ser Asp Trp Ile Tyr Leu Asp Ile Tyr Gln Asp Gly Asn 210 215 220 ACA CAA GCC ACG AAT AGA TAT ATG GCT TAT GTG CTA AAA CAC GGG CCA 720 Thr Gln Ala Thr Asn Arg Tyr Met Ala Tyr Val Leu Lys His Gly Pro 225 230 235 240 TTC CAT TTA CGA AAG TTA CTC GTG CGT AAC TAT CAC ACC TTT TTA CAG 768 Phe His Leu Arg Lys Leu Leu Val Arg Asn Tyr His Thr Phe Leu Gln 245 250 255 CGC TTT CCT GGA GCG ACG CAA AAT CGC CGC CCC TCT AAA GAT ATG CCT 816 Arg Phe Pro Gly Ala Thr Gln Asn Arg Arg Pro Ser Lys Asp Met Pro 260 265 270 GAA ACA ATC AAC AAG ACG CCT GAA ACA CAG GCA CCC AGT GGA GAC TCA 864 Glu Thr Ile Asn Lys Thr Pro Glu Thr Gln Ala Pro Ser Gly Asp Ser 275 280 285
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG GCA AAA ATA AAT AGT GAA CAC TTG GAT GAA GCT ACT ATT ACT TCG 48 Met Ala Lys Ile Asn Ser Glu His Leu Asp Glu Ala Thr Ile Thr Ser 1 5 10 15 AAT AAG TGT ACG CAA ACA GAG ACT GAG GCT CGG CAT AGA AAT GCC ACT 96 Asn Lys Cys Thr Gln Thr Glu Thr Glu Ala Arg His Arg Asn Ala Thr 20 25 30 ACA ACA CCT GAG ATG CGC CGA TTC ATA CAA GAG TCG GAT CTC AGT GTT 144 Thr Thr Pro Glu Met Arg Arg Phe Ile Gln Glu Ser Asp Leu Ser Val 35 40 45 AGC CAA CTG TCT AAA ATA TTA AAT ATC AGT GAA GCT ACC GTA CGT AAG 192 Ser Gln Leu Ser Lys Ile Leu Asn Ile Ser Glu Ala Thr Val Arg Lys 50 55 60 TGG CGC AAG CGT GAC TCT GTC GAA AAC TGT CCT AAT ACC CCG CAC CAT 240 Trp Arg Lys Arg Asp Ser Val Glu Asn Cys Pro Asn Thr Pro His His 65 70 75 80 CTC AAT ACC ACG CTA ACC CCT TTG CAA GAA TAT GTG GTT GTG GGC CTG 288 Leu Asn Thr Thr Leu Thr Pro Leu Gln Glu Tyr Val Val Val Gly Leu 85 90 95 CGT TAT CAA TTG AAA ATG CCA TTA GAC AGA TTG CTC AAA GCA ACC CAA 336 Arg Tyr Gln Leu Lys Met Pro Leu Asp Arg Leu Leu Lys Ala Thr Gln 100 105 110 GAG TTT ATC AAT CCA AAC GTG TCG CGC TCA GGT TTA GCA AGA TGT TTG 384 Glu Phe Ile Asn Pro Asn Val Ser Arg Ser Gly Leu Ala Arg Cys Leu 115 120 125 AAG CGT TAT GGC GTT TCA CGG GTG AGT GAT ATC CAA AGC CCA CAC GTA 432 Lys Arg Tyr Gly Val Ser Arg Val Ser Asp Ile Gln Ser Pro His Val 130 135 140 CCA ATG CGC TAC TTT AAT CAA ATT CCA GTC ACT CAA GGC AGC GAT GTG 480 Pro Met Arg Tyr Phe Asn Gln Ile Pro Val Thr Gln Gly Ser Asp Val 145 150 155 160 CAA ACC TAC ACC CTG CAC TAT GAA ACG CTG GCA AAA ACC TTA GCC TTA 528 Gln Thr Tyr Thr Leu His Tyr Glu Thr Leu Ala Lys Thr Leu Ala Leu 165 170 175 CCT AGT ACC GAT GGT GAC AAT GTG GTG CAA GTG GTG TCT CTC ACC ATT 576 Pro Ser Thr Asp Gly Asp Asn Val Val Gln Val Val Ser Leu Thr Ile 180 185 190 CCA CCA AAG TTA ACC GAA GAA GCA CCC AGT TCA ATT TTG CTC GGC ATT 624 Pro Pro Lys Leu Thr Glu Glu Ala Pro Ser Ser Ile Leu Leu Gly Ile 195 200 205 GAT CCT CAT AGC GAC TGG ATC TAT CTC GAC ATA TAC CAA GAT GGC AAT 672 Asp Pro His Ser Asp Trp Ile Tyr Leu Asp Ile Tyr Gln Asp Gly Asn 210 215 220 ACA CAA GCC ACG AAT AGA TAT ATG GCT TAT GTG CTA AAA CAC GGG CCA 720 Thr Gln Ala Thr Asn Arg Tyr Met Ala Tyr Val Leu Lys His Gly Pro 225 230 235 240 TTC CAT TTA CGA AAG TTA CTC GTG CGT AAC TAT CAC ACC TTT TTA CAG 768 Phe His Leu Arg Lys Leu Leu Val Arg Asn Tyr His Thr Phe Leu Gln 245 250 255 CGC TTT CCT GGA GCG ACG CAA AAT CGC CGC CCC TCT AAA GAT ATG CCT 816 Arg Phe Pro Gly Ala Thr Gln Asn Arg Arg Pro Ser Lys Asp Met Pro 260 265 270 GAA ACA ATC AAC AAG ACG CCT GAA ACA CAG GCA CCC AGT GGA GAC TCA 864 Glu Thr Ile Asn Lys Thr Pro Glu Thr Gln Ala Pro Ser Gly Asp Ser 275 280 285
【００５７】配列番号： ９ 配列の長さ：２８８ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Ala Lys Ile Asn Ser Glu His Leu Asp Glu Ala Thr Ile Thr Ser 1 5 10 15 Asn Lys Cys Thr Gln Thr Glu Thr Glu Ala Arg His Arg Asn Ala Thr 20 25 30 Thr Thr Pro Glu Met Arg Arg Phe Ile Gln Glu Ser Asp Leu Ser Val 35 40 45 Ser Gln Leu Ser Lys Ile Leu Asn Ile Ser Glu Ala Thr Val Arg Lys 50 55 60 Trp Arg Lys Arg Asp Ser Val Glu Asn Cys Pro Asn Thr Pro His His 65 70 75 80 Leu Asn Thr Thr Leu Thr Pro Leu Gln Glu Tyr Val Val Val Gly Leu 85 90 95 Arg Tyr Gln Leu Lys Met Pro Leu Asp Arg Leu Leu Lys Ala Thr Gln 100 105 110 Glu Phe Ile Asn Pro Asn Val Ser Arg Ser Gly Leu Ala Arg Cys Leu 115 120 125 Lys Arg Tyr Gly Val Ser Arg Val Ser Asp Ile Gln Ser Pro His Val 130 135 140 Pro Met Arg Tyr Phe Asn Gln Ile Pro Val Thr Gln Gly Ser Asp Val 145 150 155 160 Gln Thr Tyr Thr Leu His Tyr Glu Thr Leu Ala Lys Thr Leu Ala Leu 165 170 175 Pro Ser Thr Asp Gly Asp Asn Val Val Gln Val Val Ser Leu Thr Ile 180 185 190 Pro Pro Lys Leu Thr Glu Glu Ala Pro Ser Ser Ile Leu Leu Gly Ile 195 200 205 Asp Pro His Ser Asp Trp Ile Tyr Leu Asp Ile Tyr Gln Asp Gly Asn 210 215 220 Thr Gln Ala Thr Asn Arg Tyr Met Ala Tyr Val Leu Lys His Gly Pro 225 230 235 240 Phe His Leu Arg Lys Leu Leu Val Arg Asn Tyr His Thr Phe Leu Gln 245 250 255 Arg Phe Pro Gly Ala Thr Gln Asn Arg Arg Pro Ser Lys Asp Met Pro 260 265 270 Glu Thr Ile Asn Lys Thr Pro Glu Thr Gln Ala Pro Ser Gly Asp Ser 275 280 285
【００５８】配列番号： １０ 配列の長さ：８２６８ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AGC CAG ACC TCT AAA CCT ACA AAC TCA GCA ACT GAG CAA GCA CAA 48 Met Ser Gln Thr Ser Lys Pro Thr Asn Ser Ala Thr Glu Gln Ala Gln 1 5 10 15 GAC TCA CAA GCT GAC TCT CGT TTA AAT AAA CGA CTA AAA GAT ATG CCA 96 Asp Ser Gln Ala Asp Ser Arg Leu Asn Lys Arg Leu Lys Asp Met Pro 20 25 30 ATT GCT ATT GTT GGC ATG GCG AGT ATT TTT GCA AAC TCT CGC TAT TTG 144 Ile Ala Ile Val Gly Met Ala Ser Ile Phe Ala Asn Ser Arg Tyr Leu 35 40 45 AAT AAG TTT TGG GAC TTA ATC AGC GAA AAA ATT GAT GCG ATT ACT GAA 192 Asn Lys Phe Trp Asp Leu Ile Ser Glu Lys Ile Asp Ala Ile Thr Glu 50 55 60 TTA CCA TCA ACT CAC TGG CAG CCT GAA GAA TAT TAC GAC GCA GAT AAA 240 Leu Pro Ser Thr His Trp Gln Pro Glu Glu Tyr Tyr Asp Ala Asp Lys 65 70 75 80 ACC GCA GCA GAC AAA AGC TAC TGT AAA CGT GGT GGC TTT TTG CCA GAT 288 Thr Ala Ala Asp Lys Ser Tyr Cys Lys Arg Gly Gly Phe Leu Pro Asp 85 90 95 GTA GAC TTC AAC CCA ATG GAG TTT GGC CTG CCG CCA AAC ATT TTG GAA 336 Val Asp Phe Asn Pro Met Glu Phe Gly Leu Pro Pro Asn Ile Leu Glu 100 105 110 CTG ACC GAT TCA TCG CAA CTA TTA TCA CTC ATC GTT GCT AAA GAA GTG 384 Leu Thr Asp Ser Ser Gln Leu Leu Ser Leu Ile Val Ala Lys Glu Val 115 120 125 TTG GCT GAT GCT AAC TTA CCT GAG AAT TAC GAC CGC GAT AAA ATT GGT 432 Leu Ala Asp Ala Asn Leu Pro Glu Asn Tyr Asp Arg Asp Lys Ile Gly 130 135 140 ATC ACC TTA GGT GTC GGC GGT GGT CAA AAA ATT AGC CAC AGC CTA ACA 480 Ile Thr Leu Gly Val Gly Gly Gly Gln Lys Ile Ser His Ser Leu Thr 145 150 155 160 GCG CGT CTG CAA TAC CCA GTA TTG AAG AAA GTA TTC GCC AAT AGC GGC 528 Ala Arg Leu Gln Tyr Pro Val Leu Lys Lys Val Phe Ala Asn Ser Gly 165 170 175 ATT AGT GAC ACC GAC AGC GAA ATG CTT ATC AAG AAA TTC CAA GAC CAA 576 Ile Ser Asp Thr Asp Ser Glu Met Leu Ile Lys Lys Phe Gln Asp Gln 180 185 190 TAT GTA CAC TGG GAA GAA AAC TCG TTC CCA GGT TCA CTT GGT AAC GTT 624 Tyr Val His Trp Glu Glu Asn Ser Phe Pro Gly Ser Leu Gly Asn Val 195 200 205 ATT GCG GGC CGT ATC GCC AAC CGC TTC GAT TTT GGC GGC ATG AAC TGT 672 Ile Ala Gly Arg Ile Ala Asn Arg Phe Asp Phe Gly Gly Met Asn Cys 210 215 220 GTG GTT GAT GCT GCC TGT GCT GGA TCA CTT GCT GCT ATG CGT ATG GCG 720 Val Val Asp Ala Ala Cys Ala Gly Ser Leu Ala Ala Met Arg Met Ala 225 230 235 240 CTA ACA GAG CTA ACT GAA GGT CGC TCT GAA ATG ATG ATC ACC GGT GGT 768 Leu Thr Glu Leu Thr Glu Gly Arg Ser Glu Met Met Ile Thr Gly Gly 245 250 255 GTG TGT ACT GAT AAC TCA CCC TCT ATG TAT ATG AGC TTT TCA AAA ACG 816 Val Cys Thr Asp Asn Ser Pro Ser Met Tyr Met Ser Phe Ser Lys Thr 260 265 270 CCC GCC TTT ACC ACT AAC GAA ACC ATT CAG CCA TTT GAT ATC GAC TCA 864 Pro Ala Phe Thr Thr Asn Glu Thr Ile Gln Pro Phe Asp Ile Asp Ser 275 280 285 AAA GGC ATG ATG ATT GGT GAA GGT ATT GGC ATG GTG GCG CTA AAG CGT 912 Lys Gly Met Met Ile Gly Glu Gly Ile Gly Met Val Ala Leu Lys Arg 290 295 300 CTT GAA GAT GCA GAG CGC GAT GGC GAC CGC ATT TAC TCT GTA ATT AAA 960 Leu Glu Asp Ala Glu Arg Asp Gly Asp Arg Ile Tyr Ser Val Ile Lys 305 310 315 320 GGT GTG GGT GCA TCA TCT GAC GGT AAG TTT AAA TCA ATC TAT GCC CCT 1008 Gly Val Gly Ala Ser Ser Asp Gly Lys Phe Lys Ser Ile Tyr Ala Pro 325 330 335 CGC CCA TCA GGC CAA GCT AAA GCA CTT AAC CGT GCC TAT GAT GAC GCA 1056 Arg Pro Ser Gly Gln Ala Lys Ala Leu Asn Arg Ala Tyr Asp Asp Ala 340 345 350 GGT TTT GCG CCG CAT ACC TTA GGT CTA ATT GAA GCT CAC GGA ACA GGT 1104 Gly Phe Ala Pro His Thr Leu Gly Leu Ile Glu Ala His Gly Thr Gly 355 360 365 ACT GCA GCA GGT GAC GCG GCA GAG TTT GCC GGC CTT TGC TCA GTA TTT 1152 Thr Ala Ala Gly Asp Ala Ala Glu Phe Ala Gly Leu Cys Ser Val Phe 370 375 380 GCT GAA GGC AAC GAT ACC AAG CAA CAC ATT GCG CTA GGT TCA GTT AAA 1200 Ala Glu Gly Asn Asp Thr Lys Gln His Ile Ala Leu Gly Ser Val Lys 385 390 395 400 TCA CAA ATT GGT CAT ACT AAA TCA ACT GCA GGT ACA GCA GGT TTA ATT 1248 Ser Gln Ile Gly His Thr Lys Ser Thr Ala Gly Thr Ala Gly Leu Ile 405 410 415 AAA GCT GCT CTT GCT TTG CAT CAC AAG GTA CTG CCG CCG ACC ATT AAC 1296 Lys Ala Ala Leu Ala Leu His His Lys Val Leu Pro Pro Thr Ile Asn 420 425 430 GTT AGT CAG CCA AGC CCT AAA CTT GAT ATC GAA AAC TCA CCG TTT TAT 1344 Val Ser Gln Pro Ser Pro Lys Leu Asp Ile Glu Asn Ser Pro Phe Tyr 435 440 445 CTA AAC ACT GAG ACT CGT CCA TGG TTA CCA CGT GTT GAT GGT ACG CCG 1392 Leu Asn Thr Glu Thr Arg Pro Trp Leu Pro Arg Val Asp Gly Thr Pro 450 455 460 CGC CGC GCG GGT ATT AGC TCA TTT GGT TTT GGT GGC ACT AAC TTC CAT 1440 Arg Arg Ala Gly Ile Ser Ser Phe Gly Phe Gly Gly Thr Asn Phe His 465 470 475 480 TTT GTA CTA GAA GAG TAC AAC CAA GAA CAC AGC CGT ACT GAT AGC GAA 1488 Phe Val Leu Glu Glu Tyr Asn Gln Glu His Ser Arg Thr Asp Ser Glu 485 490 495 AAA GCT AAG TAT CGT CAA CGC CAA GTG GCG CAA AGC TTC CTT GTT AGC 1536 Lys Ala Lys Tyr Arg Gln Arg Gln Val Ala Gln Ser Phe Leu Val Ser 500 505 510 GCA AGC GAT AAA GCA TCG CTA ATT AAC GAG TTA AAC GTA CTA GCA GCA 1584 Ala Ser Asp Lys Ala Ser Leu Ile Asn Glu Leu Asn Val Leu Ala Ala 515 520 525 TCT GCA AGC CAA GCT GAG TTT ATC CTC AAA GAT GCA GCA GCA AAC TAT 1632 Ser Ala Ser Gln Ala Glu Phe Ile Leu Lys Asp Ala Ala Ala Asn Tyr 530 535 540 GGC GTA CGT GAG CTT GAT AAA AAT GCA CCA CGG ATC GGT TTA GTT GCA 1680 Gly Val Arg Glu Leu Asp Lys Asn Ala Pro Arg Ile Gly Leu Val Ala 545 550 555 560 AAC ACA GCT GAA GAG TTA GCA GGC CTA ATT AAG CAA GCA CTT GCC AAA 1728 Asn Thr Ala Glu Glu Leu Ala Gly Leu Ile Lys Gln Ala Leu Ala Lys 565 570 575 CTA GCA GCT AGC GAT GAT AAC GCA TGG CAG CTA CCT GGT GGC ACT AGC 1776 Leu Ala Ala Ser Asp Asp Asn Ala Trp Gln Leu Pro Gly Gly Thr Ser 580 585 590 TAC CGC GCC GCT GCA GTA GAA GGT AAA GTT GCC GCA CTG TTT GCT GGC 1824 Tyr Arg Ala Ala Ala Val Glu Gly Lys Val Ala Ala Leu Phe Ala Gly 595 600 605 CAA GGT TCA CAA TAT CTC AAT ATG GGC CGT GAC CTT ACT TGT TAT TAC 1872 Gln Gly Ser Gln Tyr Leu Asn Met Gly Arg Asp Leu Thr Cys Tyr Tyr 610 615 620 CCA GAG ATG CGT CAG CAA TTT GTA ACT GCA GAT AAA GTA TTT GCC GCA 1920 Pro Glu Met Arg Gln Gln Phe Val Thr Ala Asp Lys Val Phe Ala Ala 625 630 635 640 AAT GAT AAA ACG CCG TTA TCG CAA ACT CTG TAT CCA AAG CCT GTA TTT 1968 Asn Asp Lys Thr Pro Leu Ser Gln Thr Leu Tyr Pro Lys Pro Val Phe 645 650 655 AAT AAA GAT GAA TTA AAG GCT CAA GAA GCC ATT TTG ACC AAT ACC GCC 2016 Asn Lys Asp Glu Leu Lys Ala Gln Glu Ala Ile Leu Thr Asn Thr Ala 660 665 670 AAT GCC CAA AGC GCA ATT GGT GCG ATT TCA ATG GGT CAA TAC GAT TTG 2064 Asn Ala Gln Ser Ala Ile Gly Ala Ile Ser Met Gly Gln Tyr Asp Leu 675 680 685 TTT ACT GCG GCT GGC TTT AAT GCC GAC ATG GTT GCA GGC CAT AGC TTT 2112 Phe Thr Ala Ala Gly Phe Asn Ala Asp Met Val Ala Gly His Ser Phe 690 695 700 GGT GAG CTA AGT GCA CTG TGT GCT GCA GGT GTT ATT TCA GCT GAT GAC 2160 Gly Glu Leu Ser Ala Leu Cys Ala Ala Gly Val Ile Ser Ala Asp Asp 705 710 715 720 TAC TAC AAG CTG GCT TTT GCT CGT GGT GAG GCT ATG GCA ACA AAA GCA 2208 Tyr Tyr Lys Leu Ala Phe Ala Arg Gly Glu Ala Met Ala Thr Lys Ala 725 730 735 CCG GCT AAA GAC GGC GTT GAA GCA GAT GCA GGA GCA ATG TTT GCA ATC 2256 Pro Ala Lys Asp Gly Val Glu Ala Asp Ala Gly Ala Met Phe Ala Ile 740 745 750 ATA ACC AAG AGT GCT GCA GAC CTT GAA ACC GTT GAA GCC ACC ATC GCT 2304 Ile Thr Lys Ser Ala Ala Asp Leu Glu Thr Val Glu Ala Thr Ile Ala 755 760 765 AAA TTT GAT GGG GTG AAA GTC GCT AAC TAT AAC GCG CCA ACG CAA TCA 2352 Lys Phe Asp Gly Val Lys Val Ala Asn Tyr Asn Ala Pro Thr Gln Ser 770 775 780 GTA ATT GCA GGC CCA ACA GCA ACT ACC GCT GAT GCG GCT AAA GCG CTA 2400 Val Ile Ala Gly Pro Thr Ala Thr Thr Ala Asp Ala Ala Lys Ala Leu 785 790 795 800 ACT GAG CTT GGT TAC AAA GCG ATT AAC CTG CCA GTA TCA GGT GCA TTC 2448 Thr Glu Leu Gly Tyr Lys Ala Ile Asn Leu Pro Val Ser Gly Ala Phe 805 810 815 CAC ACT GAA CTT GTT GGT CAC GCT CAA GCG CCA TTT GCT AAA GCG ATT 2496 His Thr Glu Leu Val Gly His Ala Gln Ala Pro Phe Ala Lys Ala Ile 820 825 830 GAC GCA GCC AAA TTT ACT AAA ACA AGC CGA GCA CTT TAC TCA AAT GCA 2544 Asp Ala Ala Lys Phe Thr Lys Thr Ser Arg Ala Leu Tyr Ser Asn Ala 835 840 845 ACT GGC GGA CTT TAT GAA AGC ACT GCT GCA AAG ATT AAA GCC TCG TTT 2592 Thr Gly Gly Leu Tyr Glu Ser Thr Ala Ala Lys Ile Lys Ala Ser Phe 850 855 860 AAG AAA CAT ATG CTT CAA TCA GTG CGC TTT ACT AGC CAG CTA GAA GCC 2640 Lys Lys His Met Leu Gln Ser Val Arg Phe Thr Ser Gln Leu Glu Ala 865 870 875 880 ATG TAC AAC GAC GGC GCC CGT GTA TTT GTT GAA TTT GGT CCA AAG AAC 2688 Met Tyr Asn Asp Gly Ala Arg Val Phe Val Glu Phe Gly Pro Lys Asn 885 890 895 ATC TTA CAA AAA TTA GTT CAA GGC ACG CTT GTC AAC ACT GAA AAT GAA 2736 Ile Leu Gln Lys Leu Val Gln Gly Thr Leu Val Asn Thr Glu Asn Glu 900 905 910 GTT TGC ACT ATC TCT ATC AAC CCT AAT CCT AAA GTT GAT AGT GAT CTG 2784 Val Cys Thr Ile Ser Ile Asn Pro Asn Pro Lys Val Asp Ser Asp Leu 915 920 925 CAG CTT AAG CAA GCA GCA ATG CAG CTA GCG GTT ACT GGT GTG GTA CTC 2832 Gln Leu Lys Gln Ala Ala Met Gln Leu Ala Val Thr Gly Val Val Leu 930 935 940 AGT GAA ATT GAC CCA TAC CAA GCC GAT ATT GCC GCA CCA GCG AAA AAG 2880 Ser Glu Ile Asp Pro Tyr Gln Ala Asp Ile Ala Ala Pro Ala Lys Lys 945 950 955 960 TCG CCA ATG AGC ATT TCG CTT AAT GCT GCT AAC CAT ATC AGC AAA GCA 2928 Ser Pro Met Ser Ile Ser Leu Asn Ala Ala Asn His Ile Ser Lys Ala 965 970 975 ACT CGC GCT AAG ATG GCC AAG TCT TTA GAG ACA GGT ATC GTC ACC TCG 2976 Thr Arg Ala Lys Met Ala Lys Ser Leu Glu Thr Gly Ile Val Thr Ser 980 985 990 CAA ATA GAA CAT GTT ATT GAA GAA AAA ATC GTT GAA GTT GAG AAA CTG 3024 Gln Ile Glu His Val Ile Glu Glu Lys Ile Val Glu Val Glu Lys Leu 995 1000 1005 GTT GAA GTC GAA AAG ATC GTC GAA AAA GTG GTT GAA GTA GAG AAA GTT 3072 Val Glu Val Glu Lys Ile Val Glu Lys Val Val Glu Val Glu Lys Val 1010 1015 1020 GTT GAG GTT GAA GCT CCT GTT AAT TCA GTG CAA GCC AAT GCA ATT CAA 3120 Val Glu Val Glu Ala Pro Val Asn Ser Val Gln Ala Asn Ala Ile Gln 1025 1030 1035 1040 ACC CGT TCA GTT GTC GCT CCA GTA ATA GAG AAC CAA GTC GTG TCT AAA 3168 Thr Arg Ser Val Val Ala Pro Val Ile Glu Asn Gln Val Val Ser Lys 1045 1050 1055 AAC AGT AAG CCA GCA GTC CAG AGC ATT AGT GGT GAT GCA CTC AGC AAC 3216 Asn Ser Lys Pro Ala Val Gln Ser Ile Ser Gly Asp Ala Leu Ser Asn 1060 1065 1070 TTT TTT GCT GCA CAG CAG CAA ACC GCA CAG TTG CAT CAG CAG TTC TTA 3264 Phe Phe Ala Ala Gln Gln Gln Thr Ala Gln Leu His Gln Gln Phe Leu 1075 1080 1085 GCT ATT CCG CAG CAA TAT GGT GAG ACG TTC ACT ACG CTG ATG ACC GAG 3312 Ala Ile Pro Gln Gln Tyr Gly Glu Thr Phe Thr Thr Leu Met Thr Glu 1090 1095 1100 CAA GCT AAA CTG GCA AGT TCT GGT GTT GCA ATT CCA GAG AGT CTG CAA 3360 Gln Ala Lys Leu Ala Ser Ser Gly Val Ala Ile Pro Glu Ser Leu Gln 1105 1110 1115 1120 CGC TCA ATG GAG CAA TTC CAC CAA CTA CAA GCG CAA ACA CTA CAA AGC 3408 Arg Ser Met Glu Gln Phe His Gln Leu Gln Ala Gln Thr Leu Gln Ser 1125 1130 1135 CAC ACC CAG TTC CTT GAG ATG CAA GCG GGT AGC AAC ATT GCA GCG TTA 3456 His Thr Gln Phe Leu Glu Met Gln Ala Gly Ser Asn Ile Ala Ala Leu 1140 1145 1150 AAC CTA CTC AAT AGC AGC CAA GCA ACT TAC GCT CCA GCC ATT CAC AAT 3504 Asn Leu Leu Asn Ser Ser Gln Ala Thr Tyr Ala Pro Ala Ile His Asn 1155 1160 1165 GAA GCG ATT CAA AGC CAA GTG GTT CAA AGC CAA ACT GCA GTC CAG CCA 3552 Glu Ala Ile Gln Ser Gln Val Val Gln Ser Gln Thr Ala Val Gln Pro 1170 1175 1180 GTA ATT TCA ACA CAA GTT AAC CAT GTG TCA GAG CAG CCA ACT CAA GCT 3600 Val Ile Ser Thr Gln Val Asn His Val Ser Glu Gln Pro Thr Gln Ala 1185 1190 1195 1200 CCA GCT CCA AAA GCG CAG CCA GCA CCT GTG ACA ACT GCA GTT CAA ACT 3648 Pro Ala Pro Lys Ala Gln Pro Ala Pro Val Thr Thr Ala Val Gln Thr 1205 1210 1215 GCT CCG GCA CAA GTT GTT CGT CAA GCC GCA CCA GTT CAA GCC GCT ATT 3696 Ala Pro Ala Gln Val Val Arg Gln Ala Ala Pro Val Gln Ala Ala Ile 1220 1225 1230 GAA CCG ATT AAT ACA AGT GTT GCG ACT ACA ACG CCT TCA GCC TTC AGC 3744 Glu Pro Ile Asn Thr Ser Val Ala Thr Thr Thr Pro Ser Ala Phe Ser 1235 1240 1245 GCC GAA ACA GCC CTG AGC GCA ACA AAA GTC CAA GCC ACT ATG CTT GAA 3792 Ala Glu Thr Ala Leu Ser Ala Thr Lys Val Gln Ala Thr Met Leu Glu 1250 1255 1260 GTG GTT GCT GAG AAA ACC GGT TAC CCA ACT GAA ATG CTA GAG CTT GAA 3840 Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Glu 1265 1270 1275 1280 ATG GAT ATG GAA GCC GAT TTA GGC ATC GAT TCT ATC AAG CGT GTA GAA 3888 Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu 1285 1290 1295 ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT CTA CCT GAG CTT AGC 3936 Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Ser 1300 1305 1310 CCT GAA GAT CTA GCT GAG TGT CGA ACG CTA GGC GAA ATC GTT GAC TAT 3984 Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Asp Tyr 1315 1320 1325 ATG GGC AGT AAA CTG CCG GCT GAA GGC TCT ATG AAT TCT CAG CTG TCT 4032 Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser 1330 1335 1340 ACA GGT TCC GCA GCT GCG ACT CCT GCA GCG AAT GGT CTT TCT GCG GAG 4080 Thr Gly Ser Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu 1345 1350 1355 1360 AAA GTT CAA GCG ACT ATG ATG TCT GTG GTT GCC GAA AAG ACT GGC TAC 4128 Lys Val Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr 1365 1370 1375 CCA ACT GAA ATG CTA GAG CTT GAA ATG GAT ATG GAA GCC GAT TTA GGC 4176 Pro Thr Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly 1380 1385 1390 ATA GAT TCT ATC AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG 4224 Ile Asp Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu 1395 1400 1405 CTA CCG GGT CTA CCT GAG CTT AGC CCT GAA GAT CTA GCT GAG TGT CGT 4272 Leu Pro Gly Leu Pro Glu Leu Ser Pro Glu Asp Leu Ala Glu Cys Arg 1410 1415 1420 ACT CTA GGC GAA ATC GTT GAC TAT ATG AAC TCT AAA CTC GCT GAC GGC 4320 Thr Leu Gly Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly 1425 1430 1435 1440 TCT AAG CTG CCG GCT GAA GGC TCT ATG AAT TCT CAG CTG TCT ACA AGT 4368 Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser Thr Ser 1445 1450 1455 GCC GCA GCT GCG ACT CCT GCA GCG AAT GGT CTC TCT GCG GAG AAA GTT 4416 Ala Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu Lys Val 1460 1465 1470 CAA GCG ACT ATG ATG TCT GTG GTT GCC GAA AAG ACT GGC TAC CCA ACT 4464 Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr 1475 1480 1485 GAA ATG CTA GAA CTT GAA ATG GAT ATG GAA GCT GAC CTT GGC ATC GAT 4512 Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp 1490 1495 1500 TCA ATC AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG 4560 Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro 1505 1510 1515 1520 GGT TTA CCT GAG CTA AAT CCA GAA GAT TTG GCA GAG TGT CGT ACT CTT 4608 Gly Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu 1525 1530 1535 GGC GAA ATC GTG ACT TAT ATG AAC TCT AAA CTC GCT GAC GGC TCT AAG 4656 Gly Glu Ile Val Thr Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys 1540 1545 1550 CTG CCA GCT GAA GGC TCT ATG CAC TAT CAG CTG TCT ACA AGT ACC GCT 4704 Leu Pro Ala Glu Gly Ser Met His Tyr Gln Leu Ser Thr Ser Thr Ala 1555 1560 1565 GCT GCG ACT CCT GTA GCG AAT GGT CTC TCT GCA GAA AAA GTT CAA GCG 4752 Ala Ala Thr Pro Val Ala Asn Gly Leu Ser Ala Glu Lys Val Gln Ala 1570 1575 1580 ACC ATG ATG TCT GTA GTT GCA GAT AAA ACT GGC TAC CCA ACT GAA ATG 4800 Thr Met Met Ser Val Val Ala Asp Lys Thr Gly Tyr Pro Thr Glu Met 1585 1590 1595 1600 CTT GAA CTT GAA ATG GAT ATG GAA GCC GAT TTA GGT ATC GAT TCT ATC 4848 Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile 1605 1610 1615 AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT TTA 4896 Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu 1620 1625 1630 CCT GAG CTA AAT CCA GAA GAT CTA GCA GAG TGT CGC ACC CTA GGC GAA 4944 Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu 1635 1640 1645 ATC GTT GAC TAT ATG GGC AGT AAA CTG CCG GCT GAA GGC TCT GCT AAT 4992 Ile Val Asp Tyr Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Ala Asn 1650 1655 1660 ACA AGT GCC GCT GCG TCT CTT AAT GTT AGT GCC GTT GCG GCG CCT CAA 5040 Thr Ser Ala Ala Ala Ser Leu Asn Val Ser Ala Val Ala Ala Pro Gln 1665 1670 1675 1680 GCT GCT GCG ACT CCT GTA TCG AAC GGT CTC TCT GCA GAG AAA GTG CAA 5088 Ala Ala Ala Thr Pro Val Ser Asn Gly Leu Ser Ala Glu Lys Val Gln 1685 1690 1695 AGC ACT ATG ATG TCA GTA GTT GCA GAA AAG ACC GGC TAC CCA ACT GAA 5136 Ser Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu 1700 1705 1710 ATG CTA GAA CTT GGC ATG GAT ATG GAA GCC GAT TTA GGT ATC GAC TCA 5184 Met Leu Glu Leu Gly Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser 1715 1720 1725 ATT AAA CGC GTT GAG ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT 5232 Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly 1730 1735 1740 CTA CCA GAG CTT AAT CCT GAA GAT TTA GCT GAG TGC CGT ACG CTG GGC 5280 Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly 1745 1750 1755 1760 GAA ATC GTT GAC TAT ATG AAC TCT AAG CTG GCT GAC GGC TCT AAG CTT 5328 Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys Leu 1765 1770 1775 CCA GCT GAA GGC TCT GCT AAT ACA AGT GCC ACT GCT GCG ACT CCT GCA 5376 Pro Ala Glu Gly Ser Ala Asn Thr Ser Ala Thr Ala Ala Thr Pro Ala 1780 1785 1790 GTG AAT GGT CTT TCT GCT GAC AAG GTA CAG GCG ACT ATG ATG TCT GTA 5424 Val Asn Gly Leu Ser Ala Asp Lys Val Gln Ala Thr Met Met Ser Val 1795 1800 1805 GTT GCT GAA AAG ACC GGC TAC CCA ACT GAA ATG CTA GAA CTT GGC ATG 5472 Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Gly Met 1810 1815 1820 GAT ATG GAA GCA GAC CTT GGT ATT GAT TCT ATT AAG CGC GTT GAA ATT 5520 Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu Ile 1825 1830 1835 1840 CTT GGC ACA GTA CAA GAT GAG CTC CCA GGT TTA CCT GAG CTT AAT CCT 5568 Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Asn Pro 1845 1850 1855 GAA GAT CTC GCT GAG TGC CGC ACG CTT GGC GAA ATC GTT AGC TAT ATG 5616 Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Ser Tyr Met 1860 1865 1870 AAC TCT CAA CTG GCT GAT GGC TCT AAA CTT TCT ACA AGT GCG GCT GAA 5664 Asn Ser Gln Leu Ala Asp Gly Ser Lys Leu Ser Thr Ser Ala Ala Glu 1875 1880 1885 GGC TCT GCT GAT ACA AGT GCT GCA AAT GCT GCA AAG CCG GCA GCA ATT 5712 Gly Ser Ala Asp Thr Ser Ala Ala Asn Ala Ala Lys Pro Ala Ala Ile 1890 1895 1900 TCG GCA GAA CCA AGT GTT GAG CTT CCT CCT CAT AGC GAG GTA GCG CTA 5760 Ser Ala Glu Pro Ser Val Glu Leu Pro Pro His Ser Glu Val Ala Leu 1905 1910 1915 1920 AAA AAG CTT AAT GCG GCG AAC AAG CTA GAA AAT TGT TTC GCC GCA GAC 5808 Lys Lys Leu Asn Ala Ala Asn Lys Leu Glu Asn Cys Phe Ala Ala Asp 1925 1930 1935 GCA AGT GTT GTG ATT AAC GAT GAT GGT CAC AAC GCA GGC GTT TTA GCT 5856 Ala Ser Val Val Ile Asn Asp Asp Gly His Asn Ala Gly Val Leu Ala 1940 1945 1950 GAG AAA CTT ATT AAA CAA GGC CTA AAA GTA GCC GTT GTG CGT TTA CCG 5904 Glu Lys Leu Ile Lys Gln Gly Leu Lys Val Ala Val Val Arg Leu Pro 1955 1960 1965 AAA GGT CAG CCT CAA TCG CCA CTT TCA AGC GAT GTT GCT AGC TTT GAG 5952 Lys Gly Gln Pro Gln Ser Pro Leu Ser Ser Asp Val Ala Ser Phe Glu 1970 1975 1980 CTT GCC TCA AGC CAA GAA TCT GAG CTT GAA GCC AGT ATC ACT GCA GTT 6000 Leu Ala Ser Ser Gln Glu Ser Glu Leu Glu Ala Ser Ile Thr Ala Val 1985 1990 1995 2000
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AGC CAG ACC TCT AAA CCT ACA AAC TCA GCA ACT GAG CAA GCA CAA 48 Met Ser Gln Thr Ser Lys Pro Thr Asn Ser Ala Thr Glu Gln Ala Gln 1 5 10 15 GAC TCA CAA GCT GAC TCT CGT TTA AAT AAA CGA CTA AAA GAT ATG CCA 96 Asp Ser Gln Ala Asp Ser Arg Leu Asn Lys Arg Leu Lys Asp Met Pro 20 25 30 ATT GCT ATT GTT GGC ATG GCG AGT ATT TTT GCA AAC TCT CGC TAT TTG 144 Ile Ala Ile Val Gly Met Ala Ser Ile Phe Ala Asn Ser Arg Tyr Leu 35 40 45 AAT AAG TTT TGG GAC TTA ATC AGC GAA AAA ATT GAT GCG ATT ACT GAA 192 Asn Lys Phe Trp Asp Leu Ile Ser Glu Lys Ile Asp Ala Ile Thr Glu 50 55 60 TTA CCA TCA ACT CAC TGG CAG CCT GAA GAA TAT TAC GAC GCA GAT AAA 240 Leu Pro Ser Thr His Trp Gln Pro Glu Glu Tyr Tyr Asp Ala Asp Lys 65 70 75 80 ACC GCA GCA GAC AAA AGC TAC TGT AAA CGT GGT GGC TTT TTG CCA GAT 288 Thr Ala Ala Asp Lys Ser Tyr Cys Lys Arg Gly Gly Phe Leu Pro Asp 85 90 95 GTA GAC TTC AAC CCA ATG GAG TTT GGC CTG CCG CCA AAC ATT TTG GAA 336 Val Asp Phe Asn Pro Met Glu Phe Gly Leu Pro Pro Asn Ile Leu Glu 100 105 110 CTG ACC GAT TCA TCG CAA CTA TTA TCA CTC ATC GTT GCT AAA GAA GTG 384 Leu Thr Asp Ser Ser Gln Leu Leu Ser Leu Ile Val Ala Lys Glu Val 115 120 125 TTG GCT GAT GCT AAC TTA CCT GAG AAT TAC GAC CGC GAT AAA ATT GGT 432 Leu Ala Asp Ala Asn Leu Pro Glu Asn Tyr Asp Arg Asp Lys Ile Gly 130 135 140 ATC ACC TTA GGT GTC GGC GGT GGT CAA AAA ATT AGC CAC AGC CTA ACA 480 Ile Thr Leu Gly Val Gly Gly Gly Gln Lys Ile Ser His Ser Leu Thr 145 150 155 160 GCG CGT CTG CAA TAC CCA GTA TTG AAG AAA GTA TTC GCC AAT AGC GGC 528 Ala Arg Leu Gln Tyr Pro Val Leu Lys Lys Val Phe Ala Asn Ser Gly 165 170 175 ATT AGT GAC ACC GAC AGC GAA ATG CTT ATC AAG AAA TTC CAA GAC CAA 576 Ile Ser Asp Thr Asp Ser Glu Met Leu Ile Lys Lys Phe Gln Asp Gln 180 185 190 TAT GTA CAC TGG GAA GAA AAC TCG TTC CCA GGT TCA CTT GGT AAC GTT 624 Tyr Val His Trp Glu Glu Asn Ser Phe Pro Gly Ser Leu Gly Asn Val 195 200 205 ATT GCG GGC CGT ATC GCC AAC CGC TTC GAT TTT GGC GGC ATG AAC TGT 672 Ile Ala Gly Arg Ile Ala Asn Arg Phe Asp Phe Gly Gly Met Asn Cys 210 215 220 GTG GTT GAT GCT GCC TGT GCT GGA TCA CTT GCT GCT ATG CGT ATG GCG 720 Val Val Asp Ala Ala Cys Ala Gly Ser Leu Ala Ala Met Arg Met Ala 225 230 235 240 CTA ACA GAG CTA ACT GAA GGT CGC TCT GAA ATG ATG ATC ACC GGT GGT 768 Leu Thr Glu Leu Thr Glu Gly Arg Ser Glu Met Met Ile Thr Gly Gly 245 250 255 GTG TGT ACT GAT AAC TCA CCC TCT ATG TAT ATG AGC TTT TCA AAA ACG 816 Val Cys Thr Asp Asn Ser Pro Ser Met Tyr Met Ser Phe Ser Lys Thr 260 265 270 CCC GCC TTT ACC ACT AAC GAA ACC ATT CAG CCA TTT GAT ATC GAC TCA 864 Pro Ala Phe Thr Thr Asn Glu Thr Ile Gln Pro Phe Asp Ile Asp Ser 275 280 285 AAA GGC ATG ATG ATT GGT GAA GGT ATT GGC ATG GTG GCG CTA AAG CGT 912 Lys Gly Met Met Ile Gly Glu Gly Ile Gly Met Val Ala Leu Lys Arg 290 295 300 CTT GAA GAT GCA GAG CGC GAT GGC GAC CGC ATT TAC TCT GTA ATT AAA 960 Leu Glu Asp Ala Glu Arg Asp Gly Asp Arg Ile Tyr Ser Val Ile Lys 305 310 315 320 GGT GTG GGT GCA TCA TCT GAC GGT AAG TTT AAA TCA ATC TAT GCC CCT 1008 Gly Val Gly Ala Ser Ser Asp Gly Lys Phe Lys Ser Ile Tyr Ala Pro 325 330 335 CGC CCA TCA GGC CAA GCT AAA GCA CTT AAC CGT GCC TAT GAT GAC GCA 1056 Arg Pro Ser Gly Gln Ala Lys Ala Leu Asn Arg Ala Tyr Asp Asp Ala 340 345 350 GGT TTT GCG CCG CAT ACC TTA GGT CTA ATT GAA GCT CAC GGA ACA GGT 1104 Gly Phe Ala Pro His Thr Leu Gly Leu Ile Glu Ala His Gly Thr Gly 355 360 365 ACT GCA GCA GGT GAC GCG GCA GAG TTT GCC GGC CTT TGC TCA GTA TTT 1152 Thr Ala Ala Gly Asp Ala Ala Glu Phe Ala Gly Leu Cys Ser Val Phe 370 375 380 GCT GAA GGC AAC GAT ACC AAG CAA CAC ATT GCG CTA GGT TCA GTT AAA 1200 Ala Glu Gly Asn Asp Thr Lys Gln His Ile Ala Leu Gly Ser Val Lys 385 390 395 400 TCA CAA ATT GGT CAT ACT AAA TCA ACT GCA GGT ACA GCA GGT TTA ATT 1248 Ser Gln Ile Gly His Thr Lys Ser Thr Ala Gly Thr Ala Gly Leu Ile 405 410 415 AAA GCT GCT CTT GCT TTG CAT CAC AAG GTA CTG CCG CCG ACC ATT AAC 1296 Lys Ala Ala Leu Ala Leu His His Lys Val Leu Pro Pro Thr Ile Asn 420 425 430 GTT AGT CAG CCA AGC CCT AAA CTT GAT ATC GAA AAC TCA CCG TTT TAT 1344 Val Ser Gln Pro Ser Pro Lys Leu Asp Ile Glu Asn Ser Pro Phe Tyr 435 440 445 CTA AAC ACT GAG ACT CGT CCA TGG TTA CCA CGT GTT GAT GGT ACG CCG 1392 Leu Asn Thr Glu Thr Arg Pro Trp Leu Pro Arg Val Asp Gly Thr Pro 450 455 460 CGC CGC GCG GGT ATT AGC TCA TTT GGT TTT GGT GGC ACT AAC TTC CAT 1440 Arg Arg Ala Gly Ile Ser Ser Phe Gly Phe Gly Gly Thr Asn Phe His 465 470 475 480 TTT GTA CTA GAA GAG TAC AAC CAA GAA CAC AGC CGT ACT GAT AGC GAA 1488 Phe Val Leu Glu Glu Tyr Asn Gln Glu His Ser Arg Thr Asp Ser Glu 485 490 495 AAA GCT AAG TAT CGT CAA CGC CAA GTG GCG CAA AGC TTC CTT GTT AGC 1536 Lys Ala Lys Tyr Arg Gln Arg Gln Val Ala Gln Ser Phe Leu Val Ser 500 505 510 GCA AGC GAT AAA GCA TCG CTA ATT AAC GAG TTA AAC GTA CTA GCA GCA 1584 Ala Ser Asp Lys Ala Ser Leu Ile Asn Glu Leu Asn Val Leu Ala Ala 515 520 525 TCT GCA AGC CAA GCT GAG TTT ATC CTC AAA GAT GCA GCA GCA AAC TAT 1632 Ser Ala Ser Gln Ala Glu Phe Ile Leu Lys Asp Ala Ala Ala Asn Tyr 530 535 540 GGC GTA CGT GAG CTT GAT AAA AAT GCA CCA CGG ATC GGT TTA GTT GCA 1680 Gly Val Arg Glu Leu Asp Lys Asn Ala Pro Arg Ile Gly Leu Val Ala 545 550 555 560 AAC ACA GCT GAA GAG TTA GCA GGC CTA ATT AAG CAA GCA CTT GCC AAA 1728 Asn Thr Ala Glu Glu Leu Ala Gly Leu Ile Lys Gln Ala Leu Ala Lys 565 570 575 CTA GCA GCT AGC GAT GAT AAC GCA TGG CAG CTA CCT GGT GGC ACT AGC 1776 Leu Ala Ala Ser Asp Asp Asn Ala Trp Gln Leu Pro Gly Gly Thr Ser 580 585 590 TAC CGC GCC GCT GCA GTA GAA GGT AAA GTT GCC GCA CTG TTT GCT GGC 1824 Tyr Arg Ala Ala Ala Val Glu Gly Lys Val Ala Ala Leu Phe Ala Gly 595 600 605 CAA GGT TCA CAA TAT CTC AAT ATG GGC CGT GAC CTT ACT TGT TAT TAC 1872 Gln Gly Ser Gln Tyr Leu Asn Met Gly Arg Asp Leu Thr Cys Tyr Tyr 610 615 620 CCA GAG ATG CGT CAG CAA TTT GTA ACT GCA GAT AAA GTA TTT GCC GCA 1920 Pro Glu Met Arg Gln Gln Phe Val Thr Ala Asp Lys Val Phe Ala Ala 625 630 635 640 AAT GAT AAA ACG CCG TTA TCG CAA ACT CTG TAT CCA AAG CCT GTA TTT 1968 Asn Asp Lys Thr Pro Leu Ser Gln Thr Leu Tyr Pro Lys Pro Val Phe 645 650 655 AAT AAA GAT GAA TTA AAG GCT CAA GAA GCC ATT TTG ACC AAT ACC GCC 2016 Asn Lys Asp Glu Leu Lys Ala Gln Glu Ala Ile Leu Thr Asn Thr Ala 660 665 670 AAT GCC CAA AGC GCA ATT GGT GCG ATT TCA ATG GGT CAA TAC GAT TTG 2064 Asn Ala Gln Ser Ala Ile Gly Ala Ile Ser Met Gly Gln Tyr Asp Leu 675 680 685 TTT ACT GCG GCT GGC TTT AAT GCC GAC ATG GTT GCA GGC CAT AGC TTT 2112 Phe Thr Ala Ala Gly Phe Asn Ala Asp Met Val Ala Gly His Ser Phe 690 695 700 GGT GAG CTA AGT GCA CTG TGT GCT GCA GGT GTT ATT TCA GCT GAT GAC 2160 Gly Glu Leu Ser Ala Leu Cys Ala Ala Gly Val Ile Ser Ala Asp Asp 705 710 715 720 TAC TAC AAG CTG GCT TTT GCT CGT GGT GAG GCT ATG GCA ACA AAA GCA 2208 Tyr Tyr Lys Leu Ala Phe Ala Arg Gly Glu Ala Met Ala Thr Lys Ala 725 730 735 CCG GCT AAA GAC GGC GTT GAA GCA GAT GCA GGA GCA ATG TTT GCA ATC 2256 Pro Ala Lys Asp Gly Val Glu Ala Asp Ala Gly Ala Met Phe Ala Ile 740 745 750 ATA ACC AAG AGT GCT GCA GAC CTT GAA ACC GTT GAA GCC ACC ATC GCT 2304 Ile Thr Lys Ser Ala Ala Asp Leu Glu Thr Val Glu Ala Thr Ile Ala 755 760 765 AAA TTT GAT GGG GTG AAA GTC GCT AAC TAT AAC GCG CCA ACG CAA TCA 2352 Lys Phe Asp Gly Val Lys Val Ala Asn Tyr Asn Ala Pro Thr Gln Ser 770 775 780 GTA ATT GCA GGC CCA ACA GCA ACT ACC GCT GAT GCG GCT AAA GCG CTA 2400 Val Ile Ala Gly Pro Thr Ala Thr Thr Ala Asp Ala Ala Lys Ala Leu 785 790 795 800 ACT GAG CTT GGT TAC AAA GCG ATT AAC CTG CCA GTA TCA GGT GCA TTC 2448 Thr Glu Leu Gly Tyr Lys Ala Ile Asn Leu Pro Val Ser Gly Ala Phe 805 810 815 CAC ACT GAA CTT GTT GGT CAC GCT CAA GCG CCA TTT GCT AAA GCG ATT 2496 His Thr Glu Leu Val Gly His Ala Gln Ala Pro Phe Ala Lys Ala Ile 820 825 830 GAC GCA GCC AAA TTT ACT AAA ACA AGC CGA GCA CTT TAC TCA AAT GCA 2544 Asp Ala Ala Lys Phe Thr Lys Thr Ser Arg Ala Leu Tyr Ser Asn Ala 835 840 845 ACT GGC GGA CTT TAT GAA AGC ACT GCT GCA AAG ATT AAA GCC TCG TTT 2592 Thr Gly Gly Leu Tyr Glu Ser Thr Ala Ala Lys Ile Lys Ala Ser Phe 850 855 860 AAG AAA CAT ATG CTT CAA TCA GTG CGC TTT ACT AGC CAG CTA GAA GCC 2640 Lys Lys His Met Leu Gln Ser Val Arg Phe Thr Ser Gln Leu Glu Ala 865 870 875 880 ATG TAC AAC GAC GGC GCC CGT GTA TTT GTT GAA TTT GGT CCA AAG AAC 2688 Met Tyr Asn Asp Gly Ala Arg Val Phe Val Glu Phe Gly Pro Lys Asn 885 890 895 ATC TTA CAA AAA TTA GTT CAA GGC ACG CTT GTC AAC ACT GAA AAT GAA 2736 Ile Leu Gln Lys Leu Val Gln Gly Thr Leu Val Asn Thr Glu Asn Glu 900 905 910 GTT TGC ACT ATC TCT ATC AAC CCT AAT CCT AAA GTT GAT AGT GAT CTG 2784 Val Cys Thr Ile Ser Ile Asn Pro Asn Pro Lys Val Asp Ser Asp Leu 915 920 925 CAG CTT AAG CAA GCA GCA ATG CAG CTA GCG GTT ACT GGT GTG GTA CTC 2832 Gln Leu Lys Gln Ala Ala Met Gln Leu Ala Val Thr Gly Val Val Leu 930 935 940 AGT GAA ATT GAC CCA TAC CAA GCC GAT ATT GCC GCA CCA GCG AAA AAG 2880 Ser Glu Ile Asp Pro Tyr Gln Ala Asp Ile Ala Ala Pro Ala Lys Lys 945 950 955 960 TCG CCA ATG AGC ATT TCG CTT AAT GCT GCT AAC CAT ATC AGC AAA GCA 2928 Ser Pro Met Ser Ile Ser Leu Asn Ala Ala Asn His Ile Ser Lys Ala 965 970 975 ACT CGC GCT AAG ATG GCC AAG TCT TTA GAG ACA GGT ATC GTC ACC TCG 2976 Thr Arg Ala Lys Met Ala Lys Ser Leu Glu Thr Gly Ile Val Thr Ser 980 985 990 CAA ATA GAA CAT GTT ATT GAA GAA AAA ATC GTT GAA GTT GAG AAA CTG 3024 Gln Ile Glu His Val Ile Glu Glu Lys Ile Val Glu Val Glu Lys Leu 995 1000 1005 GTT GAA GTC GAA AAG ATC GTC GAA AAA GTG GTT GAA GTA GAG AAA GTT 3072 Val Glu Val Glu Lys Ile Val Glu Lys Val Val Glu Val Glu Lys Val 1010 1015 1020 GTT GAG GTT GAA GCT CCT GTT AAT TCA GTG CAA GCC AAT GCA ATT CAA 3120 Val Glu Val Glu Ala Pro Val Asn Ser Val Gln Ala Asn Ala Ile Gln 1025 1030 1035 1040 ACC CGT TCA GTT GTC GCT CCA GTA ATA GAG AAC CAA GTC GTG TCT AAA 3168 Thr Arg Ser Val Val Ala Pro Val Ile Glu Asn Gln Val Val Ser Lys 1045 1050 1055 AAC AGT AAG CCA GCA GTC CAG AGC ATT AGT GGT GAT GCA CTC AGC AAC 3216 Asn Ser Lys Pro Ala Val Gln Ser Ile Ser Gly Asp Ala Leu Ser Asn 1060 1065 1070 TTT TTT GCT GCA CAG CAG CAA ACC GCA CAG TTG CAT CAG CAG TTC TTA 3264 Phe Phe Ala Ala Gln Gln Gln Thr Ala Gln Leu His Gln Gln Phe Leu 1075 1080 1085 GCT ATT CCG CAG CAA TAT GGT GAG ACG TTC ACT ACG CTG ATG ACC GAG 3312 Ala Ile Pro Gln Gln Tyr Gly Glu Thr Phe Thr Thr Leu Met Thr Glu 1090 1095 1100 CAA GCT AAA CTG GCA AGT TCT GGT GTT GCA ATT CCA GAG AGT CTG CAA 3360 Gln Ala Lys Leu Ala Ser Ser Gly Val Ala Ile Pro Glu Ser Leu Gln 1105 1110 1115 1120 CGC TCA ATG GAG CAA TTC CAC CAA CTA CAA GCG CAA ACA CTA CAA AGC 3408 Arg Ser Met Glu Gln Phe His Gln Leu Gln Ala Gln Thr Leu Gln Ser 1125 1130 1135 CAC ACC CAG TTC CTT GAG ATG CAA GCG GGT AGC AAC ATT GCA GCG TTA 3456 His Thr Gln Phe Leu Glu Met Gln Ala Gly Ser Asn Ile Ala Ala Leu 1140 1145 1150 AAC CTA CTC AAT AGC AGC CAA GCA ACT TAC GCT CCA GCC ATT CAC AAT 3504 Asn Leu Leu Asn Ser Ser Gln Ala Thr Tyr Ala Pro Ala Ile His Asn 1155 1160 1165 GAA GCG ATT CAA AGC CAA GTG GTT CAA AGC CAA ACT GCA GTC CAG CCA 3552 Glu Ala Ile Gln Ser Gln Val Val Gln Ser Gln Thr Ala Val Gln Pro 1170 1175 1180 GTA ATT TCA ACA CAA GTT AAC CAT GTG TCA GAG CAG CCA ACT CAA GCT 3600 Val Ile Ser Thr Gln Val Asn His Val Ser Glu Gln Pro Thr Gln Ala 1185 1190 1195 1200 CCA GCT CCA AAA GCG CAG CCA GCA CCT GTG ACA ACT GCA GTT CAA ACT 3648 Pro Ala Pro Lys Ala Gln Pro Ala Pro Val Thr Thr Ala Val Gln Thr 1205 1210 1215 GCT CCG GCA CAA GTT GTT CGT CAA GCC GCA CCA GTT CAA GCC GCT ATT 3696 Ala Pro Ala Gln Val Val Arg Gln Ala Ala Pro Val Gln Ala Ala Ile 1220 1225 1230 GAA CCG ATT AAT ACA AGT GTT GCG ACT ACA ACG CCT TCA GCC TTC AGC 3744 Glu Pro Ile Asn Thr Ser Val Ala Thr Thr Thr Pro Ser Ala Phe Ser 1235 1240 1245 GCC GAA ACA GCC CTG AGC GCA ACA AAA GTC CAA GCC ACT ATG CTT GAA 3792 Ala Glu Thr Ala Leu Ser Ala Thr Lys Val Gln Ala Thr Met Leu Glu 1250 1255 1260 GTG GTT GCT GAG AAA ACC GGT TAC CCA ACT GAA ATG CTA GAG CTT GAA 3840 Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Glu 1265 1270 1275 1280 ATG GAT ATG GAA GCC GAT TTA GGC ATC GAT TCT ATC AAG CGT GTA GAA 3888 Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu 1285 1290 1295 ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT CTA CCT GAG CTT AGC 3936 Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Ser 1300 1305 1310 CCT GAA GAT CTA GCT GAG TGT CGA ACG CTA GGC GAA ATC GTT GAC TAT 3984 Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Asp Tyr 1315 1320 1325 ATG GGC AGT AAA CTG CCG GCT GAA GGC TCT ATG AAT TCT CAG CTG TCT 4032 Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser 1330 1335 1340 ACA GGT TCC GCA GCT GCG ACT CCT GCA GCG AAT GGT CTT TCT GCG GAG 4080 Thr Gly Ser Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu 1345 1350 1355 1360 AAA GTT CAA GCG ACT ATG ATG TCT GTG GTT GCC GAA AAG ACT GGC TAC 4128 Lys Val Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr 1365 1370 1375 CCA ACT GAA ATG CTA GAG CTT GAA ATG GAT ATG GAA GCC GAT TTA GGC 4176 Pro Thr Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly 1380 1385 1390 ATA GAT TCT ATC AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG 4224 Ile Asp Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu 1395 1400 1405 CTA CCG GGT CTA CCT GAG CTT AGC CCT GAA GAT CTA GCT GAG TGT CGT 4272 Leu Pro Gly Leu Pro Glu Leu Ser Pro Glu Asp Leu Ala Glu Cys Arg 1410 1415 1420 ACT CTA GGC GAA ATC GTT GAC TAT ATG AAC TCT AAA CTC GCT GAC GGC 4320 Thr Leu Gly Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly 1425 1430 1435 1440 TCT AAG CTG CCG GCT GAA GGC TCT ATG AAT TCT CAG CTG TCT ACA AGT 4368 Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser Thr Ser 1445 1450 1455 GCC GCA GCT GCG ACT CCT GCA GCG AAT GGT CTC TCT GCG GAG AAA GTT 4416 Ala Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu Lys Val 1460 1465 1470 CAA GCG ACT ATG ATG TCT GTG GTT GCC GAA AAG ACT GGC TAC CCA ACT 4464 Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr 1475 1480 1485 GAA ATG CTA GAA CTT GAA ATG GAT ATG GAA GCT GAC CTT GGC ATC GAT 4512 Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp 1490 1495 1500 TCA ATC AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG 4560 Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro 1505 1510 1515 1520 GGT TTA CCT GAG CTA AAT CCA GAA GAT TTG GCA GAG TGT CGT ACT CTT 4608 Gly Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu 1525 1530 1535 GGC GAA ATC GTG ACT TAT ATG AAC TCT AAA CTC GCT GAC GGC TCT AAG 4656 Gly Glu Ile Val Thr Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys 1540 1545 1550 CTG CCA GCT GAA GGC TCT ATG CAC TAT CAG CTG TCT ACA AGT ACC GCT 4704 Leu Pro Ala Glu Gly Ser Met His Tyr Gln Leu Ser Thr Ser Thr Ala 1555 1560 1565 GCT GCG ACT CCT GTA GCG AAT GGT CTC TCT GCA GAA AAA GTT CAA GCG 4752 Ala Ala Thr Pro Val Ala Asn Gly Leu Ser Ala Glu Lys Val Gln Ala 1570 1575 1580 ACC ATG ATG TCT GTA GTT GCA GAT AAA ACT GGC TAC CCA ACT GAA ATG 4800 Thr Met Met Ser Val Val Ala Asp Lys Thr Gly Tyr Pro Thr Glu Met 1585 1590 1595 1600 CTT GAA CTT GAA ATG GAT ATG GAA GCC GAT TTA GGT ATC GAT TCT ATC 4848 Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile 1605 1610 1615 AAG CGC GTT GAA ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT TTA 4896 Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu 1620 1625 1630 CCT GAG CTA AAT CCA GAA GAT CTA GCA GAG TGT CGC ACC CTA GGC GAA 4944 Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu 1635 1640 1645 ATC GTT GAC TAT ATG GGC AGT AAA CTG CCG GCT GAA GGC TCT GCT AAT 4992 Ile Val Asp Tyr Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Ala Asn 1650 1655 1660 ACA AGT GCC GCT GCG TCT CTT AAT GTT AGT GCC GTT GCG GCG CCT CAA 5040 Thr Ser Ala Ala Ala Ser Leu Asn Val Ser Ala Val Ala Ala Pro Gln 1665 1670 1675 1680 GCT GCT GCG ACT CCT GTA TCG AAC GGT CTC TCT GCA GAG AAA GTG CAA 5088 Ala Ala Ala Thr Pro Val Ser Asn Gly Leu Ser Ala Glu Lys Val Gln 1685 1690 1695 AGC ACT ATG ATG TCA GTA GTT GCA GAA AAG ACC GGC TAC CCA ACT GAA 5136 Ser Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu 1700 1705 1710 ATG CTA GAA CTT GGC ATG GAT ATG GAA GCC GAT TTA GGT ATC GAC TCA 5184 Met Leu Glu Leu Gly Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser 1715 1720 1725 ATT AAA CGC GTT GAG ATT CTT GGC ACA GTA CAA GAT GAG CTA CCG GGT 5232 Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly 1730 1735 1740 CTA CCA GAG CTT AAT CCT GAA GAT TTA GCT GAG TGC CGT ACG CTG GGC 5280 Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly 1745 1750 1755 1760 GAA ATC GTT GAC TAT ATG AAC TCT AAG CTG GCT GAC GGC TCT AAG CTT 5328 Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys Leu 1765 1770 1775 CCA GCT GAA GGC TCT GCT AAT ACA AGT GCC ACT GCT GCG ACT CCT GCA 5376 Pro Ala Glu Gly Ser Ala Asn Thr Ser Ala Thr Ala Ala Thr Pro Ala 1780 1785 1790 GTG AAT GGT CTT TCT GCT GAC AAG GTA CAG GCG ACT ATG ATG TCT GTA 5424 Val Asn Gly Leu Ser Ala Asp Lys Val Gln Ala Thr Met Met Ser Val 1795 1800 1805 GTT GCT GAA AAG ACC GGC TAC CCA ACT GAA ATG CTA GAA CTT GGC ATG 5472 Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Gly Met 1810 1815 1820 GAT ATG GAA GCA GAC CTT GGT ATT GAT TCT ATT AAG CGC GTT GAA ATT 5520 Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu Ile 1825 1830 1835 1840 CTT GGC ACA GTA CAA GAT GAG CTC CCA GGT TTA CCT GAG CTT AAT CCT 5568 Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Asn Pro 1845 1850 1855 GAA GAT CTC GCT GAG TGC CGC ACG CTT GGC GAA ATC GTT AGC TAT ATG 5616 Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Ser Tyr Met 1860 1865 1870 AAC TCT CAA CTG GCT GAT GGC TCT AAA CTT TCT ACA AGT GCG GCT GAA 5664 Asn Ser Gln Leu Ala Asp Gly Ser Lys Leu Ser Thr Ser Ala Ala Glu 1875 1880 1885 GGC TCT GCT GAT ACA AGT GCT GCA AAT GCT GCA AAG CCG GCA GCA ATT 5712 Gly Ser Ala Asp Thr Ser Ala Ala Asn Ala Ala Lys Pro Ala Ala Ile 1890 1895 1900 TCG GCA GAA CCA AGT GTT GAG CTT CCT CCT CAT AGC GAG GTA GCG CTA 5760 Ser Ala Glu Pro Ser Val Glu Leu Pro Pro His Ser Glu Val Ala Leu 1905 1910 1915 1920 AAA AAG CTT AAT GCG GCG AAC AAG CTA GAA AAT TGT TTC GCC GCA GAC 5808 Lys Lys Leu Asn Ala Ala Asn Lys Leu Glu Asn Cys Phe Ala Ala Asp 1925 1930 1935 GCA AGT GTT GTG ATT AAC GAT GAT GGT CAC AAC GCA GGC GTT TTA GCT 5856 Ala Ser Val Val Ile Asn Asp Asp Gly His Asn Ala Gly Val Leu Ala 1940 1945 1950 GAG AAA CTT ATT AAA CAA GGC CTA AAA GTA GCC GTT GTG CGT TTA CCG 5904 Glu Lys Leu Ile Lys Gln Gly Leu Lys Val Ala Val Val Arg Leu Pro 1955 1960 1965 AAA GGT CAG CCT CAA TCG CCA CTT TCA AGC GAT GTT GCT AGC TTT GAG 5952 Lys Gly Gln Pro Gln Ser Pro Leu Ser Ser Asp Val Ala Ser Phe Glu 1970 1975 1980 CTT GCC TCA AGC CAA GAA TCT GAG CTT GAA GCC AGT ATC ACT GCA GTT 6000 Leu Ala Ser Ser Gln Glu Ser Glu Leu Glu Ala Ser Ile Thr Ala Val 1985 1990 1995 2000
【００５９】 ATC GCG CAG ATT GAA ACT CAG GTT GGC GCT ATT GGT GGC TTT ATT CAC 6048 Ile Ala Gln Ile Glu Thr Gln Val Gly Ala Ile Gly Gly Phe Ile His 2005 2010 2015 TTG CAA CCA GAA GCG AAT ACA GAA GAG CAA ACG GCA GTA AAC CTA GAT 6096 Leu Gln Pro Glu Ala Asn Thr Glu Glu Gln Thr Ala Val Asn Leu Asp 2020 2025 2030 GCG CAA AGT TTT ACT CAC GTT AGC AAT GCG TTC TTG TGG GCC AAA TTA 6144 Ala Gln Ser Phe Thr His Val Ser Asn Ala Phe Leu Trp Ala Lys Leu 2035 2040 2045 TTG CAA CCA AAG CTC GTT GCT GGA GCA GAT GCG CGT CGC TGT TTT GTA 6192 Leu Gln Pro Lys Leu Val Ala Gly Ala Asp Ala Arg Arg Cys Phe Val 2050 2055 2060 ACA GTA AGC CGT ATC GAC GGT GGC TTT GGT TAC CTA AAT ACT GAC GCC 6240 Thr Val Ser Arg Ile Asp Gly Gly Phe Gly Tyr Leu Asn Thr Asp Ala 2065 2070 2075 2080 CTA AAA GAT GCT GAG CTA AAC CAA GCA GCA TTA GCT GGT TTA ACT AAA 6288 Leu Lys Asp Ala Glu Leu Asn Gln Ala Ala Leu Ala Gly Leu Thr Lys 2085 2090 2095 ACC TTA AGC CAT GAA TGG CCA CAA GTG TTC TGT CGC GCG CTA GAT ATT 6336 Thr Leu Ser His Glu Trp Pro Gln Val Phe Cys Arg Ala Leu Asp Ile 2100 2105 2110 GCA ACA GAT GTT GAT GCA ACC CAT CTT GCT GAT GCA ATC ACC AGT GAA 6384 Ala Thr Asp Val Asp Ala Thr His Leu Ala Asp Ala Ile Thr Ser Glu 2115 2120 2125 CTA TTT GAT AGC CAA GCT CAG CTA CCT GAA GTG GGC TTA AGC TTA ATT 6432 Leu Phe Asp Ser Gln Ala Gln Leu Pro Glu Val Gly Leu Ser Leu Ile 2130 2135 2140 GAT GGC AAA GTT AAC CGC GTA ACT CTA GTT GCT GCT GAA GCT GCA GAT 6480 Asp Gly Lys Val Asn Arg Val Thr Leu Val Ala Ala Glu Ala Ala Asp 2145 2150 2155 2160 AAA ACA GCA AAA GCA GAG CTT AAC AGC ACA GAT AAA ATC TTA GTG ACT 6528 Lys Thr Ala Lys Ala Glu Leu Asn Ser Thr Asp Lys Ile Leu Val Thr 2165 2170 2175 GGT GGG GCA AAA GGG GTG ACA TTT GAA TGT GCA CTG GCA TTA GCA TCT 6576 Gly Gly Ala Lys Gly Val Thr Phe Glu Cys Ala Leu Ala Leu Ala Ser 2180 2185 2190 CGC AGC CAG TCT CAC TTT ATC TTA GCT GGG CGC AGT GAA TTA CAA GCT 6624 Arg Ser Gln Ser His Phe Ile Leu Ala Gly Arg Ser Glu Leu Gln Ala 2195 2200 2205 TTA CCA AGC TGG GCT GAG GGT AAG CAA ACT AGC GAG CTA AAA TCA GCT 6672 Leu Pro Ser Trp Ala Glu Gly Lys Gln Thr Ser Glu Leu Lys Ser Ala 2210 2215 2220 GCA ATC GCA CAT ATT ATT TCT ACT GGT CAA AAG CCA ACG CCT AAG CAA 6720 Ala Ile Ala His Ile Ile Ser Thr Gly Gln Lys Pro Thr Pro Lys Gln 2225 2230 2235 2240 GTT GAA GCC GCT GTG TGG CCA GTG CAA AGC AGC ATT GAA ATT AAT GCC 6768 Val Glu Ala Ala Val Trp Pro Val Gln Ser Ser Ile Glu Ile Asn Ala 2245 2250 2255 GCC CTA GCC GCC TTT AAC AAA GTT GGC GCC TCA GCT GAA TAC GTC AGC 6816 Ala Leu Ala Ala Phe Asn Lys Val Gly Ala Ser Ala Glu Tyr Val Ser 2260 2265 2270 ATG GAT GTT ACC GAT AGC GCC GCA ATC ACA GCA GCA CTT AAT GGT CGC 6864 Met Asp Val Thr Asp Ser Ala Ala Ile Thr Ala Ala Leu Asn Gly Arg 2275 2280 2285 TCA AAT GAG ATC ACC GGT CTT ATT CAT GGC GCA GGT GTA CTA GCC GAC 6912 Ser Asn Glu Ile Thr Gly Leu Ile His Gly Ala Gly Val Leu Ala Asp 2290 2295 2300 AAG CAT ATT CAA GAC AAG ACT CTT GCT GAA CTT GCT AAA GTT TAT GGC 6960 Lys His Ile Gln Asp Lys Thr Leu Ala Glu Leu Ala Lys Val Tyr Gly 2305 2310 2315 2320 ACT AAA GTC AAC GGC CTA AAA GCG CTG CTC GCG GCA CTT GAG CCA AGC 7008 Thr Lys Val Asn Gly Leu Lys Ala Leu Leu Ala Ala Leu Glu Pro Ser 2325 2330 2335 AAA ATT AAA TTA CTT GCT ATG TTC TCA TCT GCA GCA GGT TTT TAC GGT 7056 Lys Ile Lys Leu Leu Ala Met Phe Ser Ser Ala Ala Gly Phe Tyr Gly 2340 2345 2350 AAT ATC GGC CAA AGC GAT TAC GCG ATG TCG AAC GAT ATT CTT AAC AAG 7104 Asn Ile Gly Gln Ser Asp Tyr Ala Met Ser Asn Asp Ile Leu Asn Lys 2355 2360 2365 GCA GCG CTG CAG TTC ACC GCT CGC AAC CCA CAA GCT AAA GTC ATG AGC 7152 Ala Ala Leu Gln Phe Thr Ala Arg Asn Pro Gln Ala Lys Val Met Ser 2370 2375 2380 TTT AAC TGG GGT CCT TGG GAT GGC GGC ATG GTT AAC CCA GCG CTT AAA 7200 Phe Asn Trp Gly Pro Trp Asp Gly Gly Met Val Asn Pro Ala Leu Lys 2385 2390 2395 2400 AAG ATG TTT ACC GAG CGT GGT GTG TAC GTT ATT CCA CTA AAA GCA GGT 7248 Lys Met Phe Thr Glu Arg Gly Val Tyr Val Ile Pro Leu Lys Ala Gly 2405 2410 2415 GCA GAG CTA TTT GCC ACT CAG CTA TTG GCT GAA ACT GGC GTG CAG TTG 7296 Ala Glu Leu Phe Ala Thr Gln Leu Leu Ala Glu Thr Gly Val Gln Leu 2420 2425 2430 CTC ATT GGT ACG TCA ATG CAA GGT GGC AGC GAC ACT AAA GCA ACT GAG 7344 Leu Ile Gly Thr Ser Met Gln Gly Gly Ser Asp Thr Lys Ala Thr Glu 2435 2440 2445 ACT GCT TCT GTA AAA AAG CTT AAT GCG GGT GAG GTG CTA AGT GCA TCG 7392 Thr Ala Ser Val Lys Lys Leu Asn Ala Gly Glu Val Leu Ser Ala Ser 2450 2455 2460 CAT CCG CGT GCT GGT GCA CAA AAA ACA CCA CTA CAA GCT GTC ACT GCA 7440 His Pro Arg Ala Gly Ala Gln Lys Thr Pro Leu Gln Ala Val Thr Ala 2465 2470 2475 2480 ACG CGT CTG TTA ACC CCA AGT GCC ATG GTC TTC ATT GAA GAT CAC CGC 7488 Thr Arg Leu Leu Thr Pro Ser Ala Met Val Phe Ile Glu Asp His Arg 2485 2490 2495 ATT GGC GGT AAC AGT GTG TTG CCA ACG GTA TGC GCC ATC GAC TGG ATG 7536 Ile Gly Gly Asn Ser Val Leu Pro Thr Val Cys Ala Ile Asp Trp Met 2500 2505 2510 CGT GAA GCG GCA AGC GAC ATG CTT GGC GCT CAA GTT AAG GTA CTT GAT 7584 Arg Glu Ala Ala Ser Asp Met Leu Gly Ala Gln Val Lys Val Leu Asp 2515 2520 2525 TAC AAG CTA TTA AAA GGC ATT GTA TTT GAG ACT GAT GAG CCG CAA GAG 7632 Tyr Lys Leu Leu Lys Gly Ile Val Phe Glu Thr Asp Glu Pro Gln Glu 2530 2535 2540 TTA ACA CTT GAG CTA ACG CCA GAC GAT TCA GAC GAA GCT ACG CTA CAA 7680 Leu Thr Leu Glu Leu Thr Pro Asp Asp Ser Asp Glu Ala Thr Leu Gln 2545 2550 2555 2560 GCA TTA ATC AGC TGT AAT GGG CGT CCG CAA TAC AAG GCG ACG CTT ATC 7728 Ala Leu Ile Ser Cys Asn Gly Arg Pro Gln Tyr Lys Ala Thr Leu Ile 2565 2570 2575 AGT GAT AAT GCC GAT ATT AAG CAA CTT AAC AAG CAG TTT GAT TTA AGC 7776 Ser Asp Asn Ala Asp Ile Lys Gln Leu Asn Lys Gln Phe Asp Leu Ser 2580 2585 2590 GCT AAG GCG ATT ACC ACA GCA AAA GAG CTT TAT AGC AAC GGC ACC TTG 7824 Ala Lys Ala Ile Thr Thr Ala Lys Glu Leu Tyr Ser Asn Gly Thr Leu 2595 2600 2605 TTC CAC GGT CCG CGT CTA CAA GGG ATC CAA TCT GTA GTG CAG TTC GAT 7872 Phe His Gly Pro Arg Leu Gln Gly Ile Gln Ser Val Val Gln Phe Asp 2610 2615 2620 GAT CAA GGC TTA ATT GCT AAA GTC GCT CTG CCT AAG GTT GAA CTT AGC 7920 Asp Gln Gly Leu Ile Ala Lys Val Ala Leu Pro Lys Val Glu Leu Ser 2625 2630 2635 2640 GAT TGT GGT GAG TTC TTG CCG CAA ACC CAC ATG GGT GGC AGT CAA CCT 7968 Asp Cys Gly Glu Phe Leu Pro Gln Thr His Met Gly Gly Ser Gln Pro 2645 2650 2655 TTT GCT GAG GAC TTG CTA TTA CAA GCT ATG CTG GTT TGG GCT CGC CTT 8016 Phe Ala Glu Asp Leu Leu Leu Gln Ala Met Leu Val Trp Ala Arg Leu 2660 2665 2670 AAA ACT GGC TCG GCA AGT TTG CCA TCA AGC ATT GGT GAG TTT ACC TCA 8064 Lys Thr Gly Ser Ala Ser Leu Pro Ser Ser Ile Gly Glu Phe Thr Ser 2675 2680 2685 TAC CAA CCA ATG GCC TTT GGT GAA ACT GGT ACC ATA GAG CTT GAA GTG 8112 Tyr Gln Pro Met Ala Phe Gly Glu Thr Gly Thr Ile Glu Leu Glu Val 2690 2695 2700 ATT AAG CAC AAC AAA CGC TCA CTT GAA GCG AAT GTT GCG CTA TAT CGT 8160 Ile Lys His Asn Lys Arg Ser Leu Glu Ala Asn Val Ala Leu Tyr Arg 2705 2710 2715 2720 GAC AAC GGC GAG TTA AGT GCC ATG TTT AAG TCA GCT AAA ATC ACC ATT 8208 Asp Asn Gly Glu Leu Ser Ala Met Phe Lys Ser Ala Lys Ile Thr Ile 2725 2730 2735 AGC AAA AGC TTA AAT TCA GCA TTT TTA CCT GCT GTC TTA GCA AAC GAC 8256 Ser Lys Ser Leu Asn Ser Ala Phe Leu Pro Ala Val Leu Ala Asn Asp 2740 2745 2750 AGT GAG GCG AAT 8268 Ser Glu Ala Asn 2755
【００６０】配列番号： １１ 配列の長さ：２７５６ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Ser Gln Thr Ser Lys Pro Thr Asn Ser Ala Thr Glu Gln Ala Gln 1 5 10 15 Asp Ser Gln Ala Asp Ser Arg Leu Asn Lys Arg Leu Lys Asp Met Pro 20 25 30 Ile Ala Ile Val Gly Met Ala Ser Ile Phe Ala Asn Ser Arg Tyr Leu 35 40 45 Asn Lys Phe Trp Asp Leu Ile Ser Glu Lys Ile Asp Ala Ile Thr Glu 50 55 60 Leu Pro Ser Thr His Trp Gln Pro Glu Glu Tyr Tyr Asp Ala Asp Lys 65 70 75 80 Thr Ala Ala Asp Lys Ser Tyr Cys Lys Arg Gly Gly Phe Leu Pro Asp 85 90 95 Val Asp Phe Asn Pro Met Glu Phe Gly Leu Pro Pro Asn Ile Leu Glu 100 105 110 Leu Thr Asp Ser Ser Gln Leu Leu Ser Leu Ile Val Ala Lys Glu Val 115 120 125 Leu Ala Asp Ala Asn Leu Pro Glu Asn Tyr Asp Arg Asp Lys Ile Gly 130 135 140 Ile Thr Leu Gly Val Gly Gly Gly Gln Lys Ile Ser His Ser Leu Thr 145 150 155 160 Ala Arg Leu Gln Tyr Pro Val Leu Lys Lys Val Phe Ala Asn Ser Gly 165 170 175 Ile Ser Asp Thr Asp Ser Glu Met Leu Ile Lys Lys Phe Gln Asp Gln 180 185 190 Tyr Val His Trp Glu Glu Asn Ser Phe Pro Gly Ser Leu Gly Asn Val 195 200 205 Ile Ala Gly Arg Ile Ala Asn Arg Phe Asp Phe Gly Gly Met Asn Cys 210 215 220 Val Val Asp Ala Ala Cys Ala Gly Ser Leu Ala Ala Met Arg Met Ala 225 230 235 240 Leu Thr Glu Leu Thr Glu Gly Arg Ser Glu Met Met Ile Thr Gly Gly 245 250 255 Val Cys Thr Asp Asn Ser Pro Ser Met Tyr Met Ser Phe Ser Lys Thr 260 265 270 Pro Ala Phe Thr Thr Asn Glu Thr Ile Gln Pro Phe Asp Ile Asp Ser 275 280 285 Lys Gly Met Met Ile Gly Glu Gly Ile Gly Met Val Ala Leu Lys Arg 290 295 300 Leu Glu Asp Ala Glu Arg Asp Gly Asp Arg Ile Tyr Ser Val Ile Lys 305 310 315 320 Gly Val Gly Ala Ser Ser Asp Gly Lys Phe Lys Ser Ile Tyr Ala Pro 325 330 335 Arg Pro Ser Gly Gln Ala Lys Ala Leu Asn Arg Ala Tyr Asp Asp Ala 340 345 350 Gly Phe Ala Pro His Thr Leu Gly Leu Ile Glu Ala His Gly Thr Gly 355 360 365 Thr Ala Ala Gly Asp Ala Ala Glu Phe Ala Gly Leu Cys Ser Val Phe 370 375 380 Ala Glu Gly Asn Asp Thr Lys Gln His Ile Ala Leu Gly Ser Val Lys 385 390 395 400 Ser Gln Ile Gly His Thr Lys Ser Thr Ala Gly Thr Ala Gly Leu Ile 405 410 415 Lys Ala Ala Leu Ala Leu His His Lys Val Leu Pro Pro Thr Ile Asn 420 425 430 Val Ser Gln Pro Ser Pro Lys Leu Asp Ile Glu Asn Ser Pro Phe Tyr 435 440 445 Leu Asn Thr Glu Thr Arg Pro Trp Leu Pro Arg Val Asp Gly Thr Pro 450 455 460 Arg Arg Ala Gly Ile Ser Ser Phe Gly Phe Gly Gly Thr Asn Phe His 465 470 475 480 Phe Val Leu Glu Glu Tyr Asn Gln Glu His Ser Arg Thr Asp Ser Glu 485 490 495 Lys Ala Lys Tyr Arg Gln Arg Gln Val Ala Gln Ser Phe Leu Val Ser 500 505 510 Ala Ser Asp Lys Ala Ser Leu Ile Asn Glu Leu Asn Val Leu Ala Ala 515 520 525 Ser Ala Ser Gln Ala Glu Phe Ile Leu Lys Asp Ala Ala Ala Asn Tyr 530 535 540 Gly Val Arg Glu Leu Asp Lys Asn Ala Pro Arg Ile Gly Leu Val Ala 545 550 555 560 Asn Thr Ala Glu Glu Leu Ala Gly Leu Ile Lys Gln Ala Leu Ala Lys 565 570 575 Leu Ala Ala Ser Asp Asp Asn Ala Trp Gln Leu Pro Gly Gly Thr Ser 580 585 590 Tyr Arg Ala Ala Ala Val Glu Gly Lys Val Ala Ala Leu Phe Ala Gly 595 600 605 Gln Gly Ser Gln Tyr Leu Asn Met Gly Arg Asp Leu Thr Cys Tyr Tyr 610 615 620 Pro Glu Met Arg Gln Gln Phe Val Thr Ala Asp Lys Val Phe Ala Ala 625 630 635 640 Asn Asp Lys Thr Pro Leu Ser Gln Thr Leu Tyr Pro Lys Pro Val Phe 645 650 655 Asn Lys Asp Glu Leu Lys Ala Gln Glu Ala Ile Leu Thr Asn Thr Ala 660 665 670 Asn Ala Gln Ser Ala Ile Gly Ala Ile Ser Met Gly Gln Tyr Asp Leu 675 680 685 Phe Thr Ala Ala Gly Phe Asn Ala Asp Met Val Ala Gly His Ser Phe 690 695 700 Gly Glu Leu Ser Ala Leu Cys Ala Ala Gly Val Ile Ser Ala Asp Asp 705 710 715 720 Tyr Tyr Lys Leu Ala Phe Ala Arg Gly Glu Ala Met Ala Thr Lys Ala 725 730 735 Pro Ala Lys Asp Gly Val Glu Ala Asp Ala Gly Ala Met Phe Ala Ile 740 745 750 Ile Thr Lys Ser Ala Ala Asp Leu Glu Thr Val Glu Ala Thr Ile Ala 755 760 765 Lys Phe Asp Gly Val Lys Val Ala Asn Tyr Asn Ala Pro Thr Gln Ser 770 775 780 Val Ile Ala Gly Pro Thr Ala Thr Thr Ala Asp Ala Ala Lys Ala Leu 785 790 795 800 Thr Glu Leu Gly Tyr Lys Ala Ile Asn Leu Pro Val Ser Gly Ala Phe 805 810 815 His Thr Glu Leu Val Gly His Ala Gln Ala Pro Phe Ala Lys Ala Ile 820 825 830 Asp Ala Ala Lys Phe Thr Lys Thr Ser Arg Ala Leu Tyr Ser Asn Ala 835 840 845 Thr Gly Gly Leu Tyr Glu Ser Thr Ala Ala Lys Ile Lys Ala Ser Phe 850 855 860 Lys Lys His Met Leu Gln Ser Val Arg Phe Thr Ser Gln Leu Glu Ala 865 870 875 880 Met Tyr Asn Asp Gly Ala Arg Val Phe Val Glu Phe Gly Pro Lys Asn 885 890 895 Ile Leu Gln Lys Leu Val Gln Gly Thr Leu Val Asn Thr Glu Asn Glu 900 905 910 Val Cys Thr Ile Ser Ile Asn Pro Asn Pro Lys Val Asp Ser Asp Leu 915 920 925 Gln Leu Lys Gln Ala Ala Met Gln Leu Ala Val Thr Gly Val Val Leu 930 935 940 Ser Glu Ile Asp Pro Tyr Gln Ala Asp Ile Ala Ala Pro Ala Lys Lys 945 950 955 960 Ser Pro Met Ser Ile Ser Leu Asn Ala Ala Asn His Ile Ser Lys Ala 965 970 975 Thr Arg Ala Lys Met Ala Lys Ser Leu Glu Thr Gly Ile Val Thr Ser 980 985 990 Gln Ile Glu His Val Ile Glu Glu Lys Ile Val Glu Val Glu Lys Leu 995 1000 1005 Val Glu Val Glu Lys Ile Val Glu Lys Val Val Glu Val Glu Lys Val 1010 1015 1020 Val Glu Val Glu Ala Pro Val Asn Ser Val Gln Ala Asn Ala Ile Gln 1025 1030 1035 1040 Thr Arg Ser Val Val Ala Pro Val Ile Glu Asn Gln Val Val Ser Lys 1045 1050 1055 Asn Ser Lys Pro Ala Val Gln Ser Ile Ser Gly Asp Ala Leu Ser Asn 1060 1065 1070 Phe Phe Ala Ala Gln Gln Gln Thr Ala Gln Leu His Gln Gln Phe Leu 1075 1080 1085 Ala Ile Pro Gln Gln Tyr Gly Glu Thr Phe Thr Thr Leu Met Thr Glu 1090 1095 1100 Gln Ala Lys Leu Ala Ser Ser Gly Val Ala Ile Pro Glu Ser Leu Gln 1105 1110 1115 1120 Arg Ser Met Glu Gln Phe His Gln Leu Gln Ala Gln Thr Leu Gln Ser 1125 1130 1135 His Thr Gln Phe Leu Glu Met Gln Ala Gly Ser Asn Ile Ala Ala Leu 1140 1145 1150 Asn Leu Leu Asn Ser Ser Gln Ala Thr Tyr Ala Pro Ala Ile His Asn 1155 1160 1165 Glu Ala Ile Gln Ser Gln Val Val Gln Ser Gln Thr Ala Val Gln Pro 1170 1175 1180 Val Ile Ser Thr Gln Val Asn His Val Ser Glu Gln Pro Thr Gln Ala 1185 1190 1195 1200 Pro Ala Pro Lys Ala Gln Pro Ala Pro Val Thr Thr Ala Val Gln Thr 1205 1210 1215 Ala Pro Ala Gln Val Val Arg Gln Ala Ala Pro Val Gln Ala Ala Ile 1220 1225 1230 Glu Pro Ile Asn Thr Ser Val Ala Thr Thr Thr Pro Ser Ala Phe Ser 1235 1240 1245 Ala Glu Thr Ala Leu Ser Ala Thr Lys Val Gln Ala Thr Met Leu Glu 1250 1255 1260 Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Glu 1265 1270 1275 1280 Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu 1285 1290 1295 Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Ser 1300 1305 1310 Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Asp Tyr 1315 1320 1325 Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser 1330 1335 1340 Thr Gly Ser Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu 1345 1350 1355 1360 Lys Val Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr 1365 1370 1375 Pro Thr Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly 1380 1385 1390 Ile Asp Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu 1395 1400 1405 Leu Pro Gly Leu Pro Glu Leu Ser Pro Glu Asp Leu Ala Glu Cys Arg 1410 1415 1420 Thr Leu Gly Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly 1425 1430 1435 1440 Ser Lys Leu Pro Ala Glu Gly Ser Met Asn Ser Gln Leu Ser Thr Ser 1445 1450 1455 Ala Ala Ala Ala Thr Pro Ala Ala Asn Gly Leu Ser Ala Glu Lys Val 1460 1465 1470 Gln Ala Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr 1475 1480 1485 Glu Met Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp 1490 1495 1500 Ser Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro 1505 1510 1515 1520 Gly Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu 1525 1530 1535 Gly Glu Ile Val Thr Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys 1540 1545 1550 Leu Pro Ala Glu Gly Ser Met His Tyr Gln Leu Ser Thr Ser Thr Ala 1555 1560 1565 Ala Ala Thr Pro Val Ala Asn Gly Leu Ser Ala Glu Lys Val Gln Ala 1570 1575 1580 Thr Met Met Ser Val Val Ala Asp Lys Thr Gly Tyr Pro Thr Glu Met 1585 1590 1595 1600 Leu Glu Leu Glu Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile 1605 1610 1615 Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu 1620 1625 1630 Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu 1635 1640 1645 Ile Val Asp Tyr Met Gly Ser Lys Leu Pro Ala Glu Gly Ser Ala Asn 1650 1655 1660 Thr Ser Ala Ala Ala Ser Leu Asn Val Ser Ala Val Ala Ala Pro Gln 1665 1670 1675 1680 Ala Ala Ala Thr Pro Val Ser Asn Gly Leu Ser Ala Glu Lys Val Gln 1685 1690 1695 Ser Thr Met Met Ser Val Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu 1700 1705 1710 Met Leu Glu Leu Gly Met Asp Met Glu Ala Asp Leu Gly Ile Asp Ser 1715 1720 1725 Ile Lys Arg Val Glu Ile Leu Gly Thr Val Gln Asp Glu Leu Pro Gly 1730 1735 1740 Leu Pro Glu Leu Asn Pro Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly 1745 1750 1755 1760 Glu Ile Val Asp Tyr Met Asn Ser Lys Leu Ala Asp Gly Ser Lys Leu 1765 1770 1775 Pro Ala Glu Gly Ser Ala Asn Thr Ser Ala Thr Ala Ala Thr Pro Ala 1780 1785 1790 Val Asn Gly Leu Ser Ala Asp Lys Val Gln Ala Thr Met Met Ser Val 1795 1800 1805 Val Ala Glu Lys Thr Gly Tyr Pro Thr Glu Met Leu Glu Leu Gly Met 1810 1815 1820 Asp Met Glu Ala Asp Leu Gly Ile Asp Ser Ile Lys Arg Val Glu Ile 1825 1830 1835 1840 Leu Gly Thr Val Gln Asp Glu Leu Pro Gly Leu Pro Glu Leu Asn Pro 1845 1850 1855 Glu Asp Leu Ala Glu Cys Arg Thr Leu Gly Glu Ile Val Ser Tyr Met 1860 1865 1870 Asn Ser Gln Leu Ala Asp Gly Ser Lys Leu Ser Thr Ser Ala Ala Glu 1875 1880 1885 Gly Ser Ala Asp Thr Ser Ala Ala Asn Ala Ala Lys Pro Ala Ala Ile 1890 1895 1900 Ser Ala Glu Pro Ser Val Glu Leu Pro Pro His Ser Glu Val Ala Leu 1905 1910 1915 1920 Lys Lys Leu Asn Ala Ala Asn Lys Leu Glu Asn Cys Phe Ala Ala Asp 1925 1930 1935 Ala Ser Val Val Ile Asn Asp Asp Gly His Asn Ala Gly Val Leu Ala 1940 1945 1950 Glu Lys Leu Ile Lys Gln Gly Leu Lys Val Ala Val Val Arg Leu Pro 1955 1960 1965 Lys Gly Gln Pro Gln Ser Pro Leu Ser Ser Asp Val Ala Ser Phe Glu 1970 1975 1980 Leu Ala Ser Ser Gln Glu Ser Glu Leu Glu Ala Ser Ile Thr Ala Val 1985 1990 1995 2000 Ile Ala Gln Ile Glu Thr Gln Val Gly Ala Ile Gly Gly Phe Ile His 2005 2010 2015 Leu Gln Pro Glu Ala Asn Thr Glu Glu Gln Thr Ala Val Asn Leu Asp 2020 2025 2030 Ala Gln Ser Phe Thr His Val Ser Asn Ala Phe Leu Trp Ala Lys Leu 2035 2040 2045 Leu Gln Pro Lys Leu Val Ala Gly Ala Asp Ala Arg Arg Cys Phe Val 2050 2055 2060 Thr Val Ser Arg Ile Asp Gly Gly Phe Gly Tyr Leu Asn Thr Asp Ala 2065 2070 2075 2080 Leu Lys Asp Ala Glu Leu Asn Gln Ala Ala Leu Ala Gly Leu Thr Lys 2085 2090 2095 Thr Leu Ser His Glu Trp Pro Gln Val Phe Cys Arg Ala Leu Asp Ile 2100 2105 2110 Ala Thr Asp Val Asp Ala Thr His Leu Ala Asp Ala Ile Thr Ser Glu 2115 2120 2125 Leu Phe Asp Ser Gln Ala Gln Leu Pro Glu Val Gly Leu Ser Leu Ile 2130 2135 2140 Asp Gly Lys Val Asn Arg Val Thr Leu Val Ala Ala Glu Ala Ala Asp 2145 2150 2155 2160 Lys Thr Ala Lys Ala Glu Leu Asn Ser Thr Asp Lys Ile Leu Val Thr 2165 2170 2175 Gly Gly Ala Lys Gly Val Thr Phe Glu Cys Ala Leu Ala Leu Ala Ser 2180 2185 2190 Arg Ser Gln Ser His Phe Ile Leu Ala Gly Arg Ser Glu Leu Gln Ala 2195 2200 2205 Leu Pro Ser Trp Ala Glu Gly Lys Gln Thr Ser Glu Leu Lys Ser Ala 2210 2215 2220 Ala Ile Ala His Ile Ile Ser Thr Gly Gln Lys Pro Thr Pro Lys Gln 2225 2230 2235 2240 Val Glu Ala Ala Val Trp Pro Val Gln Ser Ser Ile Glu Ile Asn Ala 2245 2250 2255 Ala Leu Ala Ala Phe Asn Lys Val Gly Ala Ser Ala Glu Tyr Val Ser 2260 2265 2270 Met Asp Val Thr Asp Ser Ala Ala Ile Thr Ala Ala Leu Asn Gly Arg 2275 2280 2285 Ser Asn Glu Ile Thr Gly Leu Ile His Gly Ala Gly Val Leu Ala Asp 2290 2295 2300 Lys His Ile Gln Asp Lys Thr Leu Ala Glu Leu Ala Lys Val Tyr Gly 2305 2310 2315 2320 Thr Lys Val Asn Gly Leu Lys Ala Leu Leu Ala Ala Leu Glu Pro Ser 2325 2330 2335 Lys Ile Lys Leu Leu Ala Met Phe Ser Ser Ala Ala Gly Phe Tyr Gly 2340 2345 2350 Asn Ile Gly Gln Ser Asp Tyr Ala Met Ser Asn Asp Ile Leu Asn Lys 2355 2360 2365 Ala Ala Leu Gln Phe Thr Ala Arg Asn Pro Gln Ala Lys Val Met Ser 2370 2375 2380 Phe Asn Trp Gly Pro Trp Asp Gly Gly Met Val Asn Pro Ala Leu Lys 2385 2390 2395 2400 Lys Met Phe Thr Glu Arg Gly Val Tyr Val Ile Pro Leu Lys Ala Gly 2405 2410 2415 Ala Glu Leu Phe Ala Thr Gln Leu Leu Ala Glu Thr Gly Val Gln Leu 2420 2425 2430 Leu Ile Gly Thr Ser Met Gln Gly Gly Ser Asp Thr Lys Ala Thr Glu 2435 2440 2445 Thr Ala Ser Val Lys Lys Leu Asn Ala Gly Glu Val Leu Ser Ala Ser 2450 2455 2460 His Pro Arg Ala Gly Ala Gln Lys Thr Pro Leu Gln Ala Val Thr Ala 2465 2470 2475 2480 Thr Arg Leu Leu Thr Pro Ser Ala Met Val Phe Ile Glu Asp His Arg 2485 2490 2495 Ile Gly Gly Asn Ser Val Leu Pro Thr Val Cys Ala Ile Asp Trp Met 2500 2505 2510 Arg Glu Ala Ala Ser Asp Met Leu Gly Ala Gln Val Lys Val Leu Asp 2515 2520 2525 Tyr Lys Leu Leu Lys Gly Ile Val Phe Glu Thr Asp Glu Pro Gln Glu 2530 2535 2540 Leu Thr Leu Glu Leu Thr Pro Asp Asp Ser Asp Glu Ala Thr Leu Gln 2545 2550 2555 2560 Ala Leu Ile Ser Cys Asn Gly Arg Pro Gln Tyr Lys Ala Thr Leu Ile 2565 2570 2575 Ser Asp Asn Ala Asp Ile Lys Gln Leu Asn Lys Gln Phe Asp Leu Ser 2580 2585 2590 Ala Lys Ala Ile Thr Thr Ala Lys Glu Leu Tyr Ser Asn Gly Thr Leu 2595 2600 2605 Phe His Gly Pro Arg Leu Gln Gly Ile Gln Ser Val Val Gln Phe Asp 2610 2615 2620 Asp Gln Gly Leu Ile Ala Lys Val Ala Leu Pro Lys Val Glu Leu Ser 2625 2630 2635 2640 Asp Cys Gly Glu Phe Leu Pro Gln Thr His Met Gly Gly Ser Gln Pro 2645 2650 2655 Phe Ala Glu Asp Leu Leu Leu Gln Ala Met Leu Val Trp Ala Arg Leu 2660 2665 2670 Lys Thr Gly Ser Ala Ser Leu Pro Ser Ser Ile Gly Glu Phe Thr Ser 2675 2680 2685 Tyr Gln Pro Met Ala Phe Gly Glu Thr Gly Thr Ile Glu Leu Glu Val 2690 2695 2700 Ile Lys His Asn Lys Arg Ser Leu Glu Ala Asn Val Ala Leu Tyr Arg 2705 2710 2715 2720 Asp Asn Gly Glu Leu Ser Ala Met Phe Lys Ser Ala Lys Ile Thr Ile 2725 2730 2735 Ser Lys Ser Leu Asn Ser Ala Phe Leu Pro Ala Val Leu Ala Asn Asp 2740 2745 2750 Ser Glu Ala Asn 2755
【００６１】配列番号： １２ 配列の長さ：２３４０ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GTG GAA CAA ACG CCT AAA GCT AGT GCG ATG CCG CTG CGC ATC GCA CTT 48 Val Glu Gln Thr Pro Lys Ala Ser Ala Met Pro Leu Arg Ile Ala Leu 1 5 10 15 ATC TTA CTG CCA ACA CCG CAG TTT GAA GTT AAC TCT GTC GAC CAG TCA 96 Ile Leu Leu Pro Thr Pro Gln Phe Glu Val Asn Ser Val Asp Gln Ser 20 25 30 GTA TTA GCC AGC TAT CAA ACA CTG CAG CCT GAG CTA AAT GCC CTG CTT 144 Val Leu Ala Ser Tyr Gln Thr Leu Gln Pro Glu Leu Asn Ala Leu Leu 35 40 45 AAT AGT GCG CCG ACA CCT GAA ATG CTC AGC ATC ACT ATC TCA GAT GAT 192 Asn Ser Ala Pro Thr Pro Glu Met Leu Ser Ile Thr Ile Ser Asp Asp 50 55 60 AGC GAT GCA AAC AGC TTT GAG TCG CAG CTA AAT GCT GCG ACC AAC GCA 240 Ser Asp Ala Asn Ser Phe Glu Ser Gln Leu Asn Ala Ala Thr Asn Ala 65 70 75 80 ATT AAC AAT GGC TAT ATC GTC AAG CTT GCT ACG GCA ACT CAC GCT TTG 288 Ile Asn Asn Gly Tyr Ile Val Lys Leu Ala Thr Ala Thr His Ala Leu 85 90 95 TTA ATG CTG CCT GCA TTA AAA GCG GCG CAA ATG CGG ATC CAT CCT CAT 336 Leu Met Leu Pro Ala Leu Lys Ala Ala Gln Met Arg Ile His Pro His 100 105 110 GCG CAG CTT GCC GCT ATG CAG CAA GCT AAA TCG ACG CCA ATG AGT CAA 384 Ala Gln Leu Ala Ala Met Gln Gln Ala Lys Ser Thr Pro Met Ser Gln 115 120 125 GTA TCT GGT GAG CTA AAG CTT GGC GCT AAT GCG CTA AGC CTA GCT CAG 432 Val Ser Gly Glu Leu Lys Leu Gly Ala Asn Ala Leu Ser Leu Ala Gln 130 135 140 ACT AAT GCG CTG TCT CAT GCT TTA AGC CAA GCC AAG CGT AAC TTA ACT 480 Thr Asn Ala Leu Ser His Ala Leu Ser Gln Ala Lys Arg Asn Leu Thr 145 150 155 160 GAT GTC AGC GTG AAT GAG TGT TTT GAG AAC CTC AAA AGT GAA CAG CAG 528 Asp Val Ser Val Asn Glu Cys Phe Glu Asn Leu Lys Ser Glu Gln Gln 165 170 175 TTC ACA GAG GTT TAT TCG CTT ATT CAG CAA CTT GCT AGC CGC ACC CAT 576 Phe Thr Glu Val Tyr Ser Leu Ile Gln Gln Leu Ala Ser Arg Thr His 180 185 190 GTG AGA AAA GAG GTT AAT CAA GGT GTG GAA CTT GGC CCT AAA CAA GCC 624 Val Arg Lys Glu Val Asn Gln Gly Val Glu Leu Gly Pro Lys Gln Ala 195 200 205 AAA AGC CAC TAT TGG TTT AGC GAA TTT CAC CAA AAC CGT GTT GCT GCC 672 Lys Ser His Tyr Trp Phe Ser Glu Phe His Gln Asn Arg Val Ala Ala 210 215 220 ATC AAC TTT ATT AAT GGC CAA CAA GCA ACC AGC TAT GTG CTT ACT CAA 720 Ile Asn Phe Ile Asn Gly Gln Gln Ala Thr Ser Tyr Val Leu Thr Gln 225 230 235 240 GGT TCA GGA TTG TTA GCT GCG AAA TCA ATG CTA AAC CAG CAA AGA TTA 768 Gly Ser Gly Leu Leu Ala Ala Lys Ser Met Leu Asn Gln Gln Arg Leu 245 250 255 ATG TTT ATC TTG CCG GGT AAC AGT CAG CAA CAA ATA ACC GCA TCA ATA 816 Met Phe Ile Leu Pro Gly Asn Ser Gln Gln Gln Ile Thr Ala Ser Ile 260 265 270 ACT CAG TTA ATG CAG CAA TTA GAG CGT TTG CAG GTA ACT GAG GTT AAT 864 Thr Gln Leu Met Gln Gln Leu Glu Arg Leu Gln Val Thr Glu Val Asn 275 280 285 GAG CTT TCT CTA GAA TGC CAA CTA GAG CTG CTC AGC ATA ATG TAT GAC 912 Glu Leu Ser Leu Glu Cys Gln Leu Glu Leu Leu Ser Ile Met Tyr Asp 290 295 300 AAC TTA GTC AAC GCA GAC AAA CTC ACT ACT CGC GAT AGT AAG CCC GCT 960 Asn Leu Val Asn Ala Asp Lys Leu Thr Thr Arg Asp Ser Lys Pro Ala 305 310 315 320 TAT CAG GCT GTG ATT CAA GCA AGC TCT GTT AGC GCT GCA AAG CAA GAG 1008 Tyr Gln Ala Val Ile Gln Ala Ser Ser Val Ser Ala Ala Lys Gln Glu 325 330 335 TTA AGC GCG CTT AAC GAT GCA CTC ACA GCG CTG TTT GCT GAG CAA ACA 1056 Leu Ser Ala Leu Asn Asp Ala Leu Thr Ala Leu Phe Ala Glu Gln Thr 340 345 350 AAC GCC ACA TCA ACG AAT AAA GGC TTA ATC CAA TAC AAA ACA CCG GCG 1104 Asn Ala Thr Ser Thr Asn Lys Gly Leu Ile Gln Tyr Lys Thr Pro Ala 355 360 365 GGC AGT TAC TTA ACC CTA ACA CCG CTT GGC AGC AAC AAT GAC AAC GCC 1152 Gly Ser Tyr Leu Thr Leu Thr Pro Leu Gly Ser Asn Asn Asp Asn Ala 370 375 380 CAA GCG GGT CTT GCT TTT GTC TAT CCG GGT GTG GGA ACG GTT TAC GCC 1200 Gln Ala Gly Leu Ala Phe Val Tyr Pro Gly Val Gly Thr Val Tyr Ala 385 390 395 400 GAT ATG CTT AAT GAG CTG CAT CAG TAC TTC CCT GCG CTT TAC GCC AAA 1248 Asp Met Leu Asn Glu Leu His Gln Tyr Phe Pro Ala Leu Tyr Ala Lys 405 410 415 CTT GAG CGT GAA GGC GAT TTA AAG GCG ATG CTA CAA GCA GAA GAT ATC 1296 Leu Glu Arg Glu Gly Asp Leu Lys Ala Met Leu Gln Ala Glu Asp Ile 420 425 430 TAT CAT CTT GAC CCT AAA CAT GCT GCC CAA ATG AGC TTA GGT GAC TTA 1344 Tyr His Leu Asp Pro Lys His Ala Ala Gln Met Ser Leu Gly Asp Leu 435 440 445 GCC ATT GCT GGC GTG GGG AGC AGC TAC CTG TTA ACT CAG CTG CTC ACC 1392 Ala Ile Ala Gly Val Gly Ser Ser Tyr Leu Leu Thr Gln Leu Leu Thr 450 455 460 GAT GAG TTT AAT ATT AAG CCT AAT TTT GCA TTA GGT TAC TCA ATG GGT 1440 Asp Glu Phe Asn Ile Lys Pro Asn Phe Ala Leu Gly Tyr Ser Met Gly 465 470 475 480 GAA GCA TCA ATG TGG GCA AGC TTA GGC GTA TGG CAA AAC CCG CAT GCG 1488 Glu Ala Ser Met Trp Ala Ser Leu Gly Val Trp Gln Asn Pro His Ala 485 490 495 CTG ATC AGC AAA ACC CAA ACC GAC CCG CTA TTT ACT TCT GCT ATT TCC 1536 Leu Ile Ser Lys Thr Gln Thr Asp Pro Leu Phe Thr Ser Ala Ile Ser 500 505 510 GGC AAA TTG ACC GCG GTT AGA CAA GCT TGG CAG CTT GAT GAT ACC GCA 1584 Gly Lys Leu Thr Ala Val Arg Gln Ala Trp Gln Leu Asp Asp Thr Ala 515 520 525 GCG GAA ATC CAG TGG AAT AGC TTT GTG GTT AGA AGT GAA GCA GCG CCG 1632 Ala Glu Ile Gln Trp Asn Ser Phe Val Val Arg Ser Glu Ala Ala Pro 530 535 540 ATT GAA GCC TTG CTA AAA GAT TAC CCA CAC GCT TAC CTC GCG ATT ATT 1680 Ile Glu Ala Leu Leu Lys Asp Tyr Pro His Ala Tyr Leu Ala Ile Ile 545 550 555 560 CAA GGG GAT ACC TGC GTA ATC GCT GGC TGT GAA ATC CAA TGT AAA GCG 1728 Gln Gly Asp Thr Cys Val Ile Ala Gly Cys Glu Ile Gln Cys Lys Ala 565 570 575 CTA CTT GCA GCA CTG GGT AAA CGC GGT ATT GCA GCT AAT CGT GTA ACG 1776 Leu Leu Ala Ala Leu Gly Lys Arg Gly Ile Ala Ala Asn Arg Val Thr 580 585 590 GCG ATG CAT ACG CAG CCT GCG ATG CAA GAG CAT CAA AAT GTG ATG GAT 1824 Ala Met His Thr Gln Pro Ala Met Gln Glu His Gln Asn Val Met Asp 595 600 605 TTT TAT CTG CAA CCG TTA AAA GCA GAG CTT CCT AGT GAA ATA AGC TTT 1872 Phe Tyr Leu Gln Pro Leu Lys Ala Glu Leu Pro Ser Glu Ile Ser Phe 610 615 620 ATC AGC GCC GCT GAT TTA ACT GCC AAG CAA ACG GTG AGT GAG CAA GCA 1920 Ile Ser Ala Ala Asp Leu Thr Ala Lys Gln Thr Val Ser Glu Gln Ala 625 630 635 640 CTT AGC AGC CAA GTC GTT GCT CAG TCT ATT GCC GAC ACC TTC TGC CAA 1968 Leu Ser Ser Gln Val Val Ala Gln Ser Ile Ala Asp Thr Phe Cys Gln 645 650 655 ACC TTG GAC TTT ACC GCG CTA GTA CAT CAC GCC CAA CAT CAA GGC GCT 2016 Thr Leu Asp Phe Thr Ala Leu Val His His Ala Gln His Gln Gly Ala 660 665 670 AAG CTG TTT GTT GAA ATT GGC GCG GAT AGA CAA AAC TGC ACC TTG ATA 2064 Lys Leu Phe Val Glu Ile Gly Ala Asp Arg Gln Asn Cys Thr Leu Ile 675 680 685 GAC AAG ATT GTT AAA CAA GAT GGT GCC AGC AGT GTA CAA CAT CAA CCT 2112 Asp Lys Ile Val Lys Gln Asp Gly Ala Ser Ser Val Gln His Gln Pro 690 695 700 TGT TGC ACA GTG CCT ATG AAC GCA AAA GGT AGC CAA GAT ATT ACC AGC 2160 Cys Cys Thr Val Pro Met Asn Ala Lys Gly Ser Gln Asp Ile Thr Ser 705 710 715 720 GTG ATT AAA GCG CTT GGC CAA TTA ATT AGC CAT CAG GTG CCA TTA TCG 2208 Val Ile Lys Ala Leu Gly Gln Leu Ile Ser His Gln Val Pro Leu Ser 725 730 735 GTG CAA CCA TTT ATT GAT GGA CTC AAG CGC GAG CTA ACA CTT TGC CAA 2256 Val Gln Pro Phe Ile Asp Gly Leu Lys Arg Glu Leu Thr Leu Cys Gln 740 745 750 TTG ACC AGC CAA CAG CTG GCA GCA CAT GCA AAT GTT GAC AGC AAG TTT 2304 Leu Thr Ser Gln Gln Leu Ala Ala His Ala Asn Val Asp Ser Lys Phe 755 760 765 GAG TCT AAC CAA GAC CAT TTA CTT CAA GGG GAA GTC 2340 Glu Ser Asn Gln Asp His Leu Leu Gln Gly Glu Val 770 775 780
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GTG GAA CAA ACG CCT AAA GCT AGT GCG ATG CCG CTG CGC ATC GCA CTT 48 Val Glu Gln Thr Pro Lys Ala Ser Ala Met Pro Leu Arg Ile Ala Leu 1 5 10 15 ATC TTA CTG CCA ACA CCG CAG TTT GAA GTT AAC TCT GTC GAC CAG TCA 96 Ile Leu Leu Pro Thr Pro Gln Phe Glu Val Asn Ser Val Asp Gln Ser 20 25 30 GTA TTA GCC AGC TAT CAA ACA CTG CAG CCT GAG CTA AAT GCC CTG CTT 144 Val Leu Ala Ser Tyr Gln Thr Leu Gln Pro Glu Leu Asn Ala Leu Leu 35 40 45 AAT AGT GCG CCG ACA CCT GAA ATG CTC AGC ATC ACT ATC TCA GAT GAT 192 Asn Ser Ala Pro Thr Pro Glu Met Leu Ser Ile Thr Ile Ser Asp Asp 50 55 60 AGC GAT GCA AAC AGC TTT GAG TCG CAG CTA AAT GCT GCG ACC AAC GCA 240 Ser Asp Ala Asn Ser Phe Glu Ser Gln Leu Asn Ala Ala Thr Asn Ala 65 70 75 80 ATT AAC AAT GGC TAT ATC GTC AAG CTT GCT ACG GCA ACT CAC GCT TTG 288 Ile Asn Asn Gly Tyr Ile Val Lys Leu Ala Thr Ala Thr His Ala Leu 85 90 95 TTA ATG CTG CCT GCA TTA AAA GCG GCG CAA ATG CGG ATC CAT CCT CAT 336 Leu Met Leu Pro Ala Leu Lys Ala Ala Gln Met Arg Ile His Pro His 100 105 110 GCG CAG CTT GCC GCT ATG CAG CAA GCT AAA TCG ACG CCA ATG AGT CAA 384 Ala Gln Leu Ala Ala Met Gln Gln Ala Lys Ser Thr Pro Met Ser Gln 115 120 125 GTA TCT GGT GAG CTA AAG CTT GGC GCT AAT GCG CTA AGC CTA GCT CAG 432 Val Ser Gly Glu Leu Lys Leu Gly Ala Asn Ala Leu Ser Leu Ala Gln 130 135 140 ACT AAT GCG CTG TCT CAT GCT TTA AGC CAA GCC AAG CGT AAC TTA ACT 480 Thr Asn Ala Leu Ser His Ala Leu Ser Gln Ala Lys Arg Asn Leu Thr 145 150 155 160 GAT GTC AGC GTG AAT GAG TGT TTT GAG AAC CTC AAA AGT GAA CAG CAG 528 Asp Val Ser Val Asn Glu Cys Phe Glu Asn Leu Lys Ser Glu Gln Gln 165 170 175 TTC ACA GAG GTT TAT TCG CTT ATT CAG CAA CTT GCT AGC CGC ACC CAT 576 Phe Thr Glu Val Tyr Ser Leu Ile Gln Gln Leu Ala Ser Arg Thr His 180 185 190 GTG AGA AAA GAG GTT AAT CAA GGT GTG GAA CTT GGC CCT AAA CAA GCC 624 Val Arg Lys Glu Val Asn Gln Gly Val Glu Leu Gly Pro Lys Gln Ala 195 200 205 AAA AGC CAC TAT TGG TTT AGC GAA TTT CAC CAA AAC CGT GTT GCT GCC 672 Lys Ser His Tyr Trp Phe Ser Glu Phe His Gln Asn Arg Val Ala Ala 210 215 220 ATC AAC TTT ATT AAT GGC CAA CAA GCA ACC AGC TAT GTG CTT ACT CAA 720 Ile Asn Phe Ile Asn Gly Gln Gln Ala Thr Ser Tyr Val Leu Thr Gln 225 230 235 240 GGT TCA GGA TTG TTA GCT GCG AAA TCA ATG CTA AAC CAG CAA AGA TTA 768 Gly Ser Gly Leu Leu Ala Ala Lys Ser Met Leu Asn Gln Gln Arg Leu 245 250 255 ATG TTT ATC TTG CCG GGT AAC AGT CAG CAA CAA ATA ACC GCA TCA ATA 816 Met Phe Ile Leu Pro Gly Asn Ser Gln Gln Gln Ile Thr Ala Ser Ile 260 265 270 ACT CAG TTA ATG CAG CAA TTA GAG CGT TTG CAG GTA ACT GAG GTT AAT 864 Thr Gln Leu Met Gln Gln Leu Glu Arg Leu Gln Val Thr Glu Val Asn 275 280 285 GAG CTT TCT CTA GAA TGC CAA CTA GAG CTG CTC AGC ATA ATG TAT GAC 912 Glu Leu Ser Leu Glu Cys Gln Leu Glu Leu Leu Ser Ile Met Tyr Asp 290 295 300 AAC TTA GTC AAC GCA GAC AAA CTC ACT ACT CGC GAT AGT AAG CCC GCT 960 Asn Leu Val Asn Ala Asp Lys Leu Thr Thr Arg Asp Ser Lys Pro Ala 305 310 315 320 TAT CAG GCT GTG ATT CAA GCA AGC TCT GTT AGC GCT GCA AAG CAA GAG 1008 Tyr Gln Ala Val Ile Gln Ala Ser Ser Val Ser Ala Ala Lys Gln Glu 325 330 335 TTA AGC GCG CTT AAC GAT GCA CTC ACA GCG CTG TTT GCT GAG CAA ACA 1056 Leu Ser Ala Leu Asn Asp Ala Leu Thr Ala Leu Phe Ala Glu Gln Thr 340 345 350 AAC GCC ACA TCA ACG AAT AAA GGC TTA ATC CAA TAC AAA ACA CCG GCG 1104 Asn Ala Thr Ser Thr Asn Lys Gly Leu Ile Gln Tyr Lys Thr Pro Ala 355 360 365 GGC AGT TAC TTA ACC CTA ACA CCG CTT GGC AGC AAC AAT GAC AAC GCC 1152 Gly Ser Tyr Leu Thr Leu Thr Pro Leu Gly Ser Asn Asn Asp Asn Ala 370 375 380 CAA GCG GGT CTT GCT TTT GTC TAT CCG GGT GTG GGA ACG GTT TAC GCC 1200 Gln Ala Gly Leu Ala Phe Val Tyr Pro Gly Val Gly Thr Val Tyr Ala 385 390 395 400 GAT ATG CTT AAT GAG CTG CAT CAG TAC TTC CCT GCG CTT TAC GCC AAA 1248 Asp Met Leu Asn Glu Leu His Gln Tyr Phe Pro Ala Leu Tyr Ala Lys 405 410 415 CTT GAG CGT GAA GGC GAT TTA AAG GCG ATG CTA CAA GCA GAA GAT ATC 1296 Leu Glu Arg Glu Gly Asp Leu Lys Ala Met Leu Gln Ala Glu Asp Ile 420 425 430 TAT CAT CTT GAC CCT AAA CAT GCT GCC CAA ATG AGC TTA GGT GAC TTA 1344 Tyr His Leu Asp Pro Lys His Ala Ala Gln Met Ser Leu Gly Asp Leu 435 440 445 GCC ATT GCT GGC GTG GGG AGC AGC TAC CTG TTA ACT CAG CTG CTC ACC 1392 Ala Ile Ala Gly Val Gly Ser Ser Tyr Leu Leu Thr Gln Leu Leu Thr 450 455 460 GAT GAG TTT AAT ATT AAG CCT AAT TTT GCA TTA GGT TAC TCA ATG GGT 1440 Asp Glu Phe Asn Ile Lys Pro Asn Phe Ala Leu Gly Tyr Ser Met Gly 465 470 475 480 GAA GCA TCA ATG TGG GCA AGC TTA GGC GTA TGG CAA AAC CCG CAT GCG 1488 Glu Ala Ser Met Trp Ala Ser Leu Gly Val Trp Gln Asn Pro His Ala 485 490 495 CTG ATC AGC AAA ACC CAA ACC GAC CCG CTA TTT ACT TCT GCT ATT TCC 1536 Leu Ile Ser Lys Thr Gln Thr Asp Pro Leu Phe Thr Ser Ala Ile Ser 500 505 510 GGC AAA TTG ACC GCG GTT AGA CAA GCT TGG CAG CTT GAT GAT ACC GCA 1584 Gly Lys Leu Thr Ala Val Arg Gln Ala Trp Gln Leu Asp Asp Thr Ala 515 520 525 GCG GAA ATC CAG TGG AAT AGC TTT GTG GTT AGA AGT GAA GCA GCG CCG 1632 Ala Glu Ile Gln Trp Asn Ser Phe Val Val Arg Ser Glu Ala Ala Pro 530 535 540 ATT GAA GCC TTG CTA AAA GAT TAC CCA CAC GCT TAC CTC GCG ATT ATT 1680 Ile Glu Ala Leu Leu Lys Asp Tyr Pro His Ala Tyr Leu Ala Ile Ile 545 550 555 560 CAA GGG GAT ACC TGC GTA ATC GCT GGC TGT GAA ATC CAA TGT AAA GCG 1728 Gln Gly Asp Thr Cys Val Ile Ala Gly Cys Glu Ile Gln Cys Lys Ala 565 570 575 CTA CTT GCA GCA CTG GGT AAA CGC GGT ATT GCA GCT AAT CGT GTA ACG 1776 Leu Leu Ala Ala Leu Gly Lys Arg Gly Ile Ala Ala Asn Arg Val Thr 580 585 590 GCG ATG CAT ACG CAG CCT GCG ATG CAA GAG CAT CAA AAT GTG ATG GAT 1824 Ala Met His Thr Gln Pro Ala Met Gln Glu His Gln Asn Val Met Asp 595 600 605 TTT TAT CTG CAA CCG TTA AAA GCA GAG CTT CCT AGT GAA ATA AGC TTT 1872 Phe Tyr Leu Gln Pro Leu Lys Ala Glu Leu Pro Ser Glu Ile Ser Phe 610 615 620 ATC AGC GCC GCT GAT TTA ACT GCC AAG CAA ACG GTG AGT GAG CAA GCA 1920 Ile Ser Ala Ala Asp Leu Thr Ala Lys Gln Thr Val Ser Glu Gln Ala 625 630 635 640 CTT AGC AGC CAA GTC GTT GCT CAG TCT ATT GCC GAC ACC TTC TGC CAA 1968 Leu Ser Ser Gln Val Val Ala Gln Ser Ile Ala Asp Thr Phe Cys Gln 645 650 655 ACC TTG GAC TTT ACC GCG CTA GTA CAT CAC GCC CAA CAT CAA GGC GCT 2016 Thr Leu Asp Phe Thr Ala Leu Val His His Ala Gln His Gln Gly Ala 660 665 670 AAG CTG TTT GTT GAA ATT GGC GCG GAT AGA CAA AAC TGC ACC TTG ATA 2064 Lys Leu Phe Val Glu Ile Gly Ala Asp Arg Gln Asn Cys Thr Leu Ile 675 680 685 GAC AAG ATT GTT AAA CAA GAT GGT GCC AGC AGT GTA CAA CAT CAA CCT 2112 Asp Lys Ile Val Lys Gln Asp Gly Ala Ser Ser Val Gln His Gln Pro 690 695 700 TGT TGC ACA GTG CCT ATG AAC GCA AAA GGT AGC CAA GAT ATT ACC AGC 2160 Cys Cys Thr Val Pro Met Asn Ala Lys Gly Ser Gln Asp Ile Thr Ser 705 710 715 720 GTG ATT AAA GCG CTT GGC CAA TTA ATT AGC CAT CAG GTG CCA TTA TCG 2208 Val Ile Lys Ala Leu Gly Gln Leu Ile Ser His Gln Val Pro Leu Ser 725 730 735 GTG CAA CCA TTT ATT GAT GGA CTC AAG CGC GAG CTA ACA CTT TGC CAA 2256 Val Gln Pro Phe Ile Asp Gly Leu Lys Arg Glu Leu Thr Leu Cys Gln 740 745 750 TTG ACC AGC CAA CAG CTG GCA GCA CAT GCA AAT GTT GAC AGC AAG TTT 2304 Leu Thr Ser Gln Gln Leu Ala Ala His Ala Asn Val Asp Ser Lys Phe 755 760 765 GAG TCT AAC CAA GAC CAT TTA CTT CAA GGG GAA GTC 2340 Glu Ser Asn Gln Asp His Leu Leu Gln Gly Glu Val 770 775 780
【００６２】配列番号： １３ 配列の長さ：７８０ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Val Glu Gln Thr Pro Lys Ala Ser Ala Met Pro Leu Arg Ile Ala Leu 1 5 10 15 Ile Leu Leu Pro Thr Pro Gln Phe Glu Val Asn Ser Val Asp Gln Ser 20 25 30 Val Leu Ala Ser Tyr Gln Thr Leu Gln Pro Glu Leu Asn Ala Leu Leu 35 40 45 Asn Ser Ala Pro Thr Pro Glu Met Leu Ser Ile Thr Ile Ser Asp Asp 50 55 60 Ser Asp Ala Asn Ser Phe Glu Ser Gln Leu Asn Ala Ala Thr Asn Ala 65 70 75 80 Ile Asn Asn Gly Tyr Ile Val Lys Leu Ala Thr Ala Thr His Ala Leu 85 90 95 Leu Met Leu Pro Ala Leu Lys Ala Ala Gln Met Arg Ile His Pro His 100 105 110 Ala Gln Leu Ala Ala Met Gln Gln Ala Lys Ser Thr Pro Met Ser Gln 115 120 125 Val Ser Gly Glu Leu Lys Leu Gly Ala Asn Ala Leu Ser Leu Ala Gln 130 135 140 Thr Asn Ala Leu Ser His Ala Leu Ser Gln Ala Lys Arg Asn Leu Thr 145 150 155 160 Asp Val Ser Val Asn Glu Cys Phe Glu Asn Leu Lys Ser Glu Gln Gln 165 170 175 Phe Thr Glu Val Tyr Ser Leu Ile Gln Gln Leu Ala Ser Arg Thr His 180 185 190 Val Arg Lys Glu Val Asn Gln Gly Val Glu Leu Gly Pro Lys Gln Ala 195 200 205 Lys Ser His Tyr Trp Phe Ser Glu Phe His Gln Asn Arg Val Ala Ala 210 215 220 Ile Asn Phe Ile Asn Gly Gln Gln Ala Thr Ser Tyr Val Leu Thr Gln 225 230 235 240 Gly Ser Gly Leu Leu Ala Ala Lys Ser Met Leu Asn Gln Gln Arg Leu 245 250 255 Met Phe Ile Leu Pro Gly Asn Ser Gln Gln Gln Ile Thr Ala Ser Ile 260 265 270 Thr Gln Leu Met Gln Gln Leu Glu Arg Leu Gln Val Thr Glu Val Asn 275 280 285 Glu Leu Ser Leu Glu Cys Gln Leu Glu Leu Leu Ser Ile Met Tyr Asp 290 295 300 Asn Leu Val Asn Ala Asp Lys Leu Thr Thr Arg Asp Ser Lys Pro Ala 305 310 315 320 Tyr Gln Ala Val Ile Gln Ala Ser Ser Val Ser Ala Ala Lys Gln Glu 325 330 335 Leu Ser Ala Leu Asn Asp Ala Leu Thr Ala Leu Phe Ala Glu Gln Thr 340 345 350 Asn Ala Thr Ser Thr Asn Lys Gly Leu Ile Gln Tyr Lys Thr Pro Ala 355 360 365 Gly Ser Tyr Leu Thr Leu Thr Pro Leu Gly Ser Asn Asn Asp Asn Ala 370 375 380 Gln Ala Gly Leu Ala Phe Val Tyr Pro Gly Val Gly Thr Val Tyr Ala 385 390 395 400 Asp Met Leu Asn Glu Leu His Gln Tyr Phe Pro Ala Leu Tyr Ala Lys 405 410 415 Leu Glu Arg Glu Gly Asp Leu Lys Ala Met Leu Gln Ala Glu Asp Ile 420 425 430 Tyr His Leu Asp Pro Lys His Ala Ala Gln Met Ser Leu Gly Asp Leu 435 440 445 Ala Ile Ala Gly Val Gly Ser Ser Tyr Leu Leu Thr Gln Leu Leu Thr 450 455 460 Asp Glu Phe Asn Ile Lys Pro Asn Phe Ala Leu Gly Tyr Ser Met Gly 465 470 475 480 Glu Ala Ser Met Trp Ala Ser Leu Gly Val Trp Gln Asn Pro His Ala 485 490 495 Leu Ile Ser Lys Thr Gln Thr Asp Pro Leu Phe Thr Ser Ala Ile Ser 500 505 510 Gly Lys Leu Thr Ala Val Arg Gln Ala Trp Gln Leu Asp Asp Thr Ala 515 520 525 Ala Glu Ile Gln Trp Asn Ser Phe Val Val Arg Ser Glu Ala Ala Pro 530 535 540 Ile Glu Ala Leu Leu Lys Asp Tyr Pro His Ala Tyr Leu Ala Ile Ile 545 550 555 560 Gln Gly Asp Thr Cys Val Ile Ala Gly Cys Glu Ile Gln Cys Lys Ala 565 570 575 Leu Leu Ala Ala Leu Gly Lys Arg Gly Ile Ala Ala Asn Arg Val Thr 580 585 590 Ala Met His Thr Gln Pro Ala Met Gln Glu His Gln Asn Val Met Asp 595 600 605 Phe Tyr Leu Gln Pro Leu Lys Ala Glu Leu Pro Ser Glu Ile Ser Phe 610 615 620 Ile Ser Ala Ala Asp Leu Thr Ala Lys Gln Thr Val Ser Glu Gln Ala 625 630 635 640 Leu Ser Ser Gln Val Val Ala Gln Ser Ile Ala Asp Thr Phe Cys Gln 645 650 655 Thr Leu Asp Phe Thr Ala Leu Val His His Ala Gln His Gln Gly Ala 660 665 670 Lys Leu Phe Val Glu Ile Gly Ala Asp Arg Gln Asn Cys Thr Leu Ile 675 680 685 Asp Lys Ile Val Lys Gln Asp Gly Ala Ser Ser Val Gln His Gln Pro 690 695 700 Cys Cys Thr Val Pro Met Asn Ala Lys Gly Ser Gln Asp Ile Thr Ser 705 710 715 720 Val Ile Lys Ala Leu Gly Gln Leu Ile Ser His Gln Val Pro Leu Ser 725 730 735 Val Gln Pro Phe Ile Asp Gly Leu Lys Arg Glu Leu Thr Leu Cys Gln 740 745 750 Leu Thr Ser Gln Gln Leu Ala Ala His Ala Asn Val Asp Ser Lys Phe 755 760 765 Glu Ser Asn Gln Asp His Leu Leu Gln Gly Glu Val 770 775 780
【００６３】配列番号： １４ 配列の長さ：６０１２ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG TCA TTA CCA GAC AAT GCT TCT AAC CAC CTT TCT GCC AAC CAG AAA 48 Met Ser Leu Pro Asp Asn Ala Ser Asn His Leu Ser Ala Asn Gln Lys 1 5 10 15 GGC GCA TCT CAG GCA AGT AAA ACC AGT AAG CAA AGC AAA ATC GCC ATT 96 Gly Ala Ser Gln Ala Ser Lys Thr Ser Lys Gln Ser Lys Ile Ala Ile 20 25 30 GTC GGT TTA GCC ACT CTG TAT CCA GAC GCT AAA ACC CCG CAA GAA TTT 144 Val Gly Leu Ala Thr Leu Tyr Pro Asp Ala Lys Thr Pro Gln Glu Phe 35 40 45 TGG CAG AAT TTG CTG GAT AAA CGC GAC TCT CGC AGC ACC TTA ACT AAC 192 Trp Gln Asn Leu Leu Asp Lys Arg Asp Ser Arg Ser Thr Leu Thr Asn 50 55 60 GAA AAA CTC GGC GCT AAC AGC CAA GAT TAT CAA GGT GTG CAA GGC CAA 240 Glu Lys Leu Gly Ala Asn Ser Gln Asp Tyr Gln Gly Val Gln Gly Gln 65 70 75 80 TCT GAC CGT TTT TAT TGT AAT AAA GGC GGC TAC ATT GAG AAC TTC AGC 288 Ser Asp Arg Phe Tyr Cys Asn Lys Gly Gly Tyr Ile Glu Asn Phe Ser 85 90 95 TTT AAT GCT GCA GGC TAC AAA TTG CCG GAG CAA AGC TTA AAT GGC TTG 336 Phe Asn Ala Ala Gly Tyr Lys Leu Pro Glu Gln Ser Leu Asn Gly Leu 100 105 110 GAC GAC AGC TTC CTT TGG GCG CTC GAT ACT AGC CGT AAC GCA CTA ATT 384 Asp Asp Ser Phe Leu Trp Ala Leu Asp Thr Ser Arg Asn Ala Leu Ile 115 120 125 GAT GCT GGT ATT GAT ATC AAC GGC GCT GAT TTA AGC CGC GCA GGT GTA 432 Asp Ala Gly Ile Asp Ile Asn Gly Ala Asp Leu Ser Arg Ala Gly Val 130 135 140 GTC ATG GGC GCG CTG TCG TTC CCA ACT ACC CGC TCA AAC GAT CTG TTT 480 Val Met Gly Ala Leu Ser Phe Pro Thr Thr Arg Ser Asn Asp Leu Phe 145 150 155 160 TTG CCA ATT TAT CAC AGC GCC GTT GAA AAA GCC CTG CAA GAT AAA CTA 528 Leu Pro Ile Tyr His Ser Ala Val Glu Lys Ala Leu Gln Asp Lys Leu 165 170 175 GGC GTA AAG GCA TTT AAG CTA AGC CCA ACT AAT GCT CAT ACC GCT CGC 576 Gly Val Lys Ala Phe Lys Leu Ser Pro Thr Asn Ala His Thr Ala Arg 180 185 190 GCG GCA AAT GAG AGC AGC CTA AAT GCA GCC AAT GGT GCC ATT GCC CAT 624 Ala Ala Asn Glu Ser Ser Leu Asn Ala Ala Asn Gly Ala Ile Ala His 195 200 205 AAC AGC TCA AAA GTG GTG GCC GAT GCA CTT GGC CTT GGC GGC GCA CAA 672 Asn Ser Ser Lys Val Val Ala Asp Ala Leu Gly Leu Gly Gly Ala Gln 210 215 220 CTA AGC CTA GAT GCT GCC TGT GCT AGT TCG GTT TAC TCA TTA AAG CTT 720 Leu Ser Leu Asp Ala Ala Cys Ala Ser Ser Val Tyr Ser Leu Lys Leu 225 230 235 240 GCC TGC GAT TAC CTA AGC ACT GGC AAA GCC GAT ATC ATG CTA GCA GGC 768 Ala Cys Asp Tyr Leu Ser Thr Gly Lys Ala Asp Ile Met Leu Ala Gly 245 250 255 GCA GTA TCT GGC GCG GAT CCT TTC TTT ATT AAT ATG GGA TTC TCA ATC 816 Ala Val Ser Gly Ala Asp Pro Phe Phe Ile Asn Met Gly Phe Ser Ile 260 265 270 TTC CAC GCC TAC CCA GAC CAT GGT ATC TCA GTA CCG TTT GAT GCC AGC 864 Phe His Ala Tyr Pro Asp His Gly Ile Ser Val Pro Phe Asp Ala Ser 275 280 285 AGT AAA GGT TTG TTT GCT GGC GAA GGC GCT GGC GTA TTA GTG CTT AAA 912 Ser Lys Gly Leu Phe Ala Gly Glu Gly Ala Gly Val Leu Val Leu Lys 290 295 300 CGT CTT GAA GAT GCC GAG CGC GAC AAT GAC AAA ATC TAT GCG GTT GTT 960 Arg Leu Glu Asp Ala Glu Arg Asp Asn Asp Lys Ile Tyr Ala Val Val 305 310 315 320 AGC GGC GTA GGT CTA TCA AAC GAC GGT AAA GGC CAG TTT GTA TTA AGC 1008 Ser Gly Val Gly Leu Ser Asn Asp Gly Lys Gly Gln Phe Val Leu Ser 325 330 335 CCT AAT CCA AAA GGT CAG GTG AAG GCC TTT GAA CGT GCT TAT GCT GCC 1056 Pro Asn Pro Lys Gly Gln Val Lys Ala Phe Glu Arg Ala Tyr Ala Ala 340 345 350 AGT GAC ATT GAG CCA AAA GAC ATT GAA GTG ATT GAG TGC CAC GCA ACA 1104 Ser Asp Ile Glu Pro Lys Asp Ile Glu Val Ile Glu Cys His Ala Thr 355 360 365 GGC ACA CCG CTT GGC GAT AAA ATT GAG CTC ACT TCA ATG GAA ACC TTC 1152 Gly Thr Pro Leu Gly Asp Lys Ile Glu Leu Thr Ser Met Glu Thr Phe 370 375 380 TTT GAA GAC AAG CTG CAA GGC ACC GAT GCA CCG TTA ATT GGC TCA GCT 1200 Phe Glu Asp Lys Leu Gln Gly Thr Asp Ala Pro Leu Ile Gly Ser Ala 385 390 395 400 AAG TCT AAC TTA GGC CAC CTA TTA ACT GCA GCG CAT GCG GGG ATC ATG 1248 Lys Ser Asn Leu Gly His Leu Leu Thr Ala Ala His Ala Gly Ile Met 405 410 415 AAG ATG ATC TTC GCC ATG AAA GAA GGT TAC CTG CCG CCA AGT ATC AAT 1296 Lys Met Ile Phe Ala Met Lys Glu Gly Tyr Leu Pro Pro Ser Ile Asn 420 425 430 ATT AGT GAT GCT ATC GCT TCG CCG AAA AAA CTC TTC GGT AAA CCA ACC 1344 Ile Ser Asp Ala Ile Ala Ser Pro Lys Lys Leu Phe Gly Lys Pro Thr 435 440 445 CTG CCT AGC ATG GTT CAA GGC TGG CCA GAT AAG CCA TCG AAT AAT CAT 1392 Leu Pro Ser Met Val Gln Gly Trp Pro Asp Lys Pro Ser Asn Asn His 450 455 460 TTT GGT GTA AGA ACC CGT CAC GCA GGC GTA TCG GTA TTT GGC TTT GGT 1440 Phe Gly Val Arg Thr Arg His Ala Gly Val Ser Val Phe Gly Phe Gly 465 470 475 480 GGC TGT AAC GCC CAT CTG TTG CTT GAG TCA TAC AAC GGC AAA GGA ACA 1488 Gly Cys Asn Ala His Leu Leu Leu Glu Ser Tyr Asn Gly Lys Gly Thr 485 490 495 GTA AAG GCA GAA GCC ACT CAA GTA CCG CGT CAA GCT GAG CCG CTA AAA 1536 Val Lys Ala Glu Ala Thr Gln Val Pro Arg Gln Ala Glu Pro Leu Lys 500 505 510 GTG GTT GGC CTT GCC TCG CAC TTT GGG CCT CTT AGC AGC ATT AAT GCA 1584 Val Val Gly Leu Ala Ser His Phe Gly Pro Leu Ser Ser Ile Asn Ala 515 520 525 CTC AAC AAT GCT GTG ACC CAA GAT GGG AAT GGC TTT ATC GAA CTG CCG 1632 Leu Asn Asn Ala Val Thr Gln Asp Gly Asn Gly Phe Ile Glu Leu Pro 530 535 540 AAA AAG CGC TGG AAA GGC CTT GAA AAG CAC AGT GAA CTG TTA GCT GAA 1680 Lys Lys Arg Trp Lys Gly Leu Glu Lys His Ser Glu Leu Leu Ala Glu 545 550 555 560 TTT GGC TTA GCA TCT GCG CCA AAA GGT GCT TAT GTT GAT AAC TTC GAG 1728 Phe Gly Leu Ala Ser Ala Pro Lys Gly Ala Tyr Val Asp Asn Phe Glu 565 570 575 CTG GAC TTT TTA CGC TTT AAA CTG CCG CCA AAC GAA GAT GAC CGT TTG 1776 Leu Asp Phe Leu Arg Phe Lys Leu Pro Pro Asn Glu Asp Asp Arg Leu 580 585 590 ATC TCA CAG CAG CTA ATG CTA ATG CGA GTA ACA GAC GAA GCC ATT CGT 1824 Ile Ser Gln Gln Leu Met Leu Met Arg Val Thr Asp Glu Ala Ile Arg 595 600 605 GAT GCC AAG CTT GAG CCG GGG CAA AAA GTA GCT GTA TTA GTG GCA ATG 1872 Asp Ala Lys Leu Glu Pro Gly Gln Lys Val Ala Val Leu Val Ala Met 610 615 620 GAA ACT GAG CTT GAA CTG CAT CAG TTC CGC GGC CGG GTT AAC TTG CAT 1920 Glu Thr Glu Leu Glu Leu His Gln Phe Arg Gly Arg Val Asn Leu His 625 630 635 640 ACT CAA TTA GCG CAA AGT CTT GCC GCC ATG GGC GTG AGT TTA TCA ACG 1968 Thr Gln Leu Ala Gln Ser Leu Ala Ala Met Gly Val Ser Leu Ser Thr 645 650 655 GAT GAA TAC CAA GCG CTT GAA GCC ATC GCC ATG GAC AGC GTG CTT GAT 2016 Asp Glu Tyr Gln Ala Leu Glu Ala Ile Ala Met Asp Ser Val Leu Asp 660 665 670 GCT GCC AAG CTC AAT CAG TAC ACC AGC TTT ATT GGT AAT ATT ATG GCG 2064 Ala Ala Lys Leu Asn Gln Tyr Thr Ser Phe Ile Gly Asn Ile Met Ala 675 680 685 TCA CGC GTG GCG TCA CTA TGG GAC TTT AAT GGC CCA GCC TTC ACT ATT 2112 Ser Arg Val Ala Ser Leu Trp Asp Phe Asn Gly Pro Ala Phe Thr Ile 690 695 700 TCA GCA GCA GAG CAA TCT GTG AGC CGC TGT ATC GAT GTG GCG CAA AAC 2160 Ser Ala Ala Glu Gln Ser Val Ser Arg Cys Ile Asp Val Ala Gln Asn 705 710 715 720 CTC ATC ATG GAG GAT AAC CTA GAT GCG GTG GTG ATT GCA GCG GTC GAT 2208 Leu Ile Met Glu Asp Asn Leu Asp Ala Val Val Ile Ala Ala Val Asp 725 730 735 CTC TCT GGT AGC TTT GAG CAA GTC ATT CTT AAA AAT GCC ATT GCA CCT 2256 Leu Ser Gly Ser Phe Glu Gln Val Ile Leu Lys Asn Ala Ile Ala Pro 740 745 750 GTA GCC ATT GAG CCA AAC CTC GAA GCA AGC CTT AAT CCA ACA TCA GCA 2304 Val Ala Ile Glu Pro Asn Leu Glu Ala Ser Leu Asn Pro Thr Ser Ala 755 760 765 AGC TGG AAT GTC GGT GAA GGT GCT GGC GCG GTC GTG CTT GTT AAA AAT 2352 Ser Trp Asn Val Gly Glu Gly Ala Gly Ala Val Val Leu Val Lys Asn 770 775 780 GAA GCT ACA TCG GGC TGC TCA TAC GGC CAA ATT GAT GCA CTT GGC TTT 2400 Glu Ala Thr Ser Gly Cys Ser Tyr Gly Gln Ile Asp Ala Leu Gly Phe 785 790 795 800 GCT AAA ACT GCC GAA ACA GCG TTG GCT ACC GAC AAG CTA CTG AGC CAA 2448 Ala Lys Thr Ala Glu Thr Ala Leu Ala Thr Asp Lys Leu Leu Ser Gln 805 810 815 ACT GCC ACA GAC TTT AAT AAG GTT AAA GTG ATT GAA ACT ATG GCA GCG 2496 Thr Ala Thr Asp Phe Asn Lys Val Lys Val Ile Glu Thr Met Ala Ala 820 825 830 CCT GCT AGC CAA ATT CAA TTA GCG CCA ATA GTT AGC TCT CAA GTG ACT 2544 Pro Ala Ser Gln Ile Gln Leu Ala Pro Ile Val Ser Ser Gln Val Thr 835 840 845 CAC ACT GCT GCA GAG CAG CGT GTT GGT CAC TGC TTT GCT GCA GCG GGT 2592 His Thr Ala Ala Glu Gln Arg Val Gly His Cys Phe Ala Ala Ala Gly 850 855 860 ATG GCA AGC CTA TTA CAC GGC TTA CTT AAC TTA AAT ACT GTA GCC CAA 2640 Met Ala Ser Leu Leu His Gly Leu Leu Asn Leu Asn Thr Val Ala Gln 865 870 875 880 ACC AAT AAA GCC AAT TGC GCG CTT ATC AAC AAT ATC AGT GAA AAC CAA 2688 Thr Asn Lys Ala Asn Cys Ala Leu Ile Asn Asn Ile Ser Glu Asn Gln 885 890 895 TTA TCA CAG CTG TTG ATT AGC CAA ACA GCG AGC GAA CAA CAA GCA TTA 2736 Leu Ser Gln Leu Leu Ile Ser Gln Thr Ala Ser Glu Gln Gln Ala Leu 900 905 910 ACC GCG CGT TTA AGC AAT GAG CTT AAA TCC GAT GCT AAA CAC CAA CTG 2784 Thr Ala Arg Leu Ser Asn Glu Leu Lys Ser Asp Ala Lys His Gln Leu 915 920 925 GTT AAG CAA GTC ACC TTA GGT GGC CGT GAT ATC TAC CAG CAT ATT GTT 2832 Val Lys Gln Val Thr Leu Gly Gly Arg Asp Ile Tyr Gln His Ile Val 930 935 940 GAT ACA CCG CTT GCA AGC CTT GAA AGC ATT ACT CAG AAA TTG GCG CAA 2880 Asp Thr Pro Leu Ala Ser Leu Glu Ser Ile Thr Gln Lys Leu Ala Gln 945 950 955 960 GCG ACA GCA TCG ACA GTG GTC AAC CAA GTT AAA CCT ATT AAG GCC GCT 2928 Ala Thr Ala Ser Thr Val Val Asn Gln Val Lys Pro Ile Lys Ala Ala 965 970 975 GGC TCA GTC GAA ATG GCT AAC TCA TTC GAA ACG GAA AGC TCA GCA GAG 2976 Gly Ser Val Glu Met Ala Asn Ser Phe Glu Thr Glu Ser Ser Ala Glu 980 985 990 CCA CAA ATA ACA ATT GCA GCA CAA CAG ACT GCA AAC ATT GGC GTC ACC 3024 Pro Gln Ile Thr Ile Ala Ala Gln Gln Thr Ala Asn Ile Gly Val Thr 995 1000 1005 GCT CAG GCA ACC AAA CGT GAA TTA GGT ACC CCA CCA ATG ACA ACA AAT 3072 Ala Gln Ala Thr Lys Arg Glu Leu Gly Thr Pro Pro Met Thr Thr Asn 1010 1015 1020 ACC ATT GCT AAT ACA GCA AAT AAT TTA GAC AAG ACT CTT GAG ACT GTT 3120 Thr Ile Ala Asn Thr Ala Asn Asn Leu Asp Lys Thr Leu Glu Thr Val 1025 1030 1035 1040 GCT GGC AAT ACT GTT GCT AGC AAG GTT GGC TCT GGC GAC ATA GTC AAT 3168 Ala Gly Asn Thr Val Ala Ser Lys Val Gly Ser Gly Asp Ile Val Asn 1045 1050 1055 TTT CAA CAG AAC CAA CAA TTG GCT CAA CAA GCT CAC CTC GCC TTT CTT 3216 Phe Gln Gln Asn Gln Gln Leu Ala Gln Gln Ala His Leu Ala Phe Leu 1060 1065 1070 GAA AGC CGC AGT GCG GGT ATG AAG GTG GCT GAT GCT TTA TTG AAG CAA 3264 Glu Ser Arg Ser Ala Gly Met Lys Val Ala Asp Ala Leu Leu Lys Gln 1075 1080 1085 CAG CTA GCT CAA GTA ACA GGC CAA ACT ATC GAT AAT CAG GCC CTC GAT 3312 Gln Leu Ala Gln Val Thr Gly Gln Thr Ile Asp Asn Gln Ala Leu Asp 1090 1095 1100 ACT CAA GCC GTC GAT ACT CAA ACA AGC GAG AAT GTA GCG ATT GCC GCA 3360 Thr Gln Ala Val Asp Thr Gln Thr Ser Glu Asn Val Ala Ile Ala Ala 1105 1110 1115 1120 GAA TCA CCA GTT CAA GTT ACA ACA CCT GTT CAA GTT ACA ACA CCT GTT 3408 Glu Ser Pro Val Gln Val Thr Thr Pro Val Gln Val Thr Thr Pro Val 1125 1130 1135 CAA ATC AGT GTT GTG GAG TTA AAA CCA GAT CAC GCT AAT GTG CCA CCA 3456 Gln Ile Ser Val Val Glu Leu Lys Pro Asp His Ala Asn Val Pro Pro 1140 1145 1150 TAC ACG CCG CCA GTG CCT GCA TTA AAG CCG TGT ATC TGG AAC TAT GCC 3504 Tyr Thr Pro Pro Val Pro Ala Leu Lys Pro Cys Ile Trp Asn Tyr Ala 1155 1160 1165 GAT TTA GTT GAG TAC GCA GAA GGC GAT ATC GCC AAG GTA TTT GGC AGT 3552 Asp Leu Val Glu Tyr Ala Glu Gly Asp Ile Ala Lys Val Phe Gly Ser 1170 1175 1180 GAT TAT GCC ATT ATC GAC AGC TAC TCG CGC CGC GTA CGT CTA CCG ACC 3600 Asp Tyr Ala Ile Ile Asp Ser Tyr Ser Arg Arg Val Arg Leu Pro Thr 1185 1190 1195 1200 ACT GAC TAC CTG TTG GTA TCG CGC GTG ACC AAA CTT GAT GCG ACC ATC 3648 Thr Asp Tyr Leu Leu Val Ser Arg Val Thr Lys Leu Asp Ala Thr Ile 1205 1210 1215 AAT CAA TTT AAG CCA TGC TCA ATG ACC ACT GAG TAC GAC ATC CCT GTT 3696 Asn Gln Phe Lys Pro Cys Ser Met Thr Thr Glu Tyr Asp Ile Pro Val 1220 1225 1230 GAT GCG CCG TAC TTA GTA GAC GGA CAA ATC CCT TGG GCG GTA GCA GTA 3744 Asp Ala Pro Tyr Leu Val Asp Gly Gln Ile Pro Trp Ala Val Ala Val 1235 1240 1245 GAA TCA GGC CAA TGT GAC TTG ATG CTT ATT AGC TAT CTC GGT ATC GAC 3792 Glu Ser Gly Gln Cys Asp Leu Met Leu Ile Ser Tyr Leu Gly Ile Asp 1250 1255 1260 TTT GAG AAC AAA GGC GAG CGG GTT TAT CGA CTA CTC GAT TGT ACC CTC 3840 Phe Glu Asn Lys Gly Glu Arg Val Tyr Arg Leu Leu Asp Cys Thr Leu 1265 1270 1275 1280 ACC TTC CTA GGC GAC TTG CCA CGT GGC GGA GAT ACC CTA CGT TAC GAC 3888 Thr Phe Leu Gly Asp Leu Pro Arg Gly Gly Asp Thr Leu Arg Tyr Asp 1285 1290 1295 ATT AAG ATC AAT AAC TAT GCT CGC AAC GGC GAC ACC CTG CTG TTC TTC 3936 Ile Lys Ile Asn Asn Tyr Ala Arg Asn Gly Asp Thr Leu Leu Phe Phe 1300 1305 1310 TTC TCG TAT GAG TGT TTT GTT GGC GAC AAG ATG ATC CTC AAG ATG GAT 3984 Phe Ser Tyr Glu Cys Phe Val Gly Asp Lys Met Ile Leu Lys Met Asp 1315 1320 1325 GGC GGC TGC GCT GGC TTC TTC ACT GAT GAA GAG CTT GCC GAC GGT AAA 4032 Gly Gly Cys Ala Gly Phe Phe Thr Asp Glu Glu Leu Ala Asp Gly Lys 1330 1335 1340 GGC GTG ATT CGC ACA GAA GAA GAG ATT AAA GCT CGC AGC CTA GTG CAA 4080 Gly Val Ile Arg Thr Glu Glu Glu Ile Lys Ala Arg Ser Leu Val Gln 1345 1350 1355 1360 AAG CAA CGC TTT AAT CCG TTA CTA GAT TGT CCT AAA ACC CAA TTT AGT 4128 Lys Gln Arg Phe Asn Pro Leu Leu Asp Cys Pro Lys Thr Gln Phe Ser 1365 1370 1375 TAT GGT GAT ATT CAT AAG CTA TTA ACT GCT GAT ATT GAG GGT TGT TTT 4176 Tyr Gly Asp Ile His Lys Leu Leu Thr Ala Asp Ile Glu Gly Cys Phe 1380 1385 1390 GGC CCA AGC CAC AGT GGC GTC CAC CAG CCG TCA CTT TGT TTC GCA TCT 4224 Gly Pro Ser His Ser Gly Val His Gln Pro Ser Leu Cys Phe Ala Ser 1395 1400 1405 GAA AAA TTC TTG ATG ATT GAA CAA GTC AGC AAG GTT GAT CGC ACT GGC 4272 Glu Lys Phe Leu Met Ile Glu Gln Val Ser Lys Val Asp Arg Thr Gly 1410 1415 1420 GGT ACT TGG GGA CTT GGC TTA ATT GAG GGT CAT AAG CAG CTT GAA GCA 4320 Gly Thr Trp Gly Leu Gly Leu Ile Glu Gly His Lys Gln Leu Glu Ala 1425 1430 1435 1440 GAC CAC TGG TAC TTC CCA TGT CAT TTC AAG GGC GAC CAA GTG ATG GCT 4368 Asp His Trp Tyr Phe Pro Cys His Phe Lys Gly Asp Gln Val Met Ala 1445 1450 1455 GGC TCG CTA ATG GCT GAA GGT TGT GGC CAG TTA TTG CAG TTC TAT ATG 4416 Gly Ser Leu Met Ala Glu Gly Cys Gly Gln Leu Leu Gln Phe Tyr Met 1460 1465 1470 CTG CAC CTT GGT ATG CAT ACC CAA ACT AAA AAT GGT CGT TTC CAA CCT 4464 Leu His Leu Gly Met His Thr Gln Thr Lys Asn Gly Arg Phe Gln Pro 1475 1480 1485 CTT GAA AAC GCC TCA CAG CAA GTA CGC TGT CGC GGT CAA GTG CTG CCA 4512 Leu Glu Asn Ala Ser Gln Gln Val Arg Cys Arg Gly Gln Val Leu Pro 1490 1495 1500 CAA TCA GGC GTG CTA ACT TAC CGT ATG GAA GTG ACT GAA ATC GGT TTC 4560 Gln Ser Gly Val Leu Thr Tyr Arg Met Glu Val Thr Glu Ile Gly Phe 1505 1510 1515 1520 AGT CCA CGC CCA TAT GCT AAA GCT AAC ATC GAT ATC TTG CTT AAT GGC 4608 Ser Pro Arg Pro Tyr Ala Lys Ala Asn Ile Asp Ile Leu Leu Asn Gly 1525 1530 1535 AAA GCG GTA GTG GAT TTC CAA AAC CTA GGG GTG ATG ATA AAA GAG GAA 4656 Lys Ala Val Val Asp Phe Gln Asn Leu Gly Val Met Ile Lys Glu Glu 1540 1545 1550 GAT GAG TGT ACT CGT TAT CCA CTT TTG ACT GAA TCA ACA ACG GCT AGC 4704 Asp Glu Cys Thr Arg Tyr Pro Leu Leu Thr Glu Ser Thr Thr Ala Ser 1555 1560 1565 ACT GCA CAA GTA AAC GCT CAA ACA AGT GCG AAA AAG GTA TAC AAG CCA 4752 Thr Ala Gln Val Asn Ala Gln Thr Ser Ala Lys Lys Val Tyr Lys Pro 1570 1575 1580 GCA TCA GTC AAT GCG CCA TTA ATG GCA CAA ATT CCT GAT CTG ACT AAA 4800 Ala Ser Val Asn Ala Pro Leu Met Ala Gln Ile Pro Asp Leu Thr Lys 1585 1590 1595 1600 GAG CCA AAC AAG GGC GTT ATT CCG ATT TCC CAT GTT GAA GCA CCA ATT 4848 Glu Pro Asn Lys Gly Val Ile Pro Ile Ser His Val Glu Ala Pro Ile 1605 1610 1615 ACG CCA GAC TAC CCG AAC CGT GTA CCT GAT ACA GTG CCA TTC ACG CCG 4896 Thr Pro Asp Tyr Pro Asn Arg Val Pro Asp Thr Val Pro Phe Thr Pro 1620 1625 1630 TAT CAC ATG TTT GAG TTT GCT ACA GGC AAT ATC GAA AAC TGT TTC GGG 4944 Tyr His Met Phe Glu Phe Ala Thr Gly Asn Ile Glu Asn Cys Phe Gly 1635 1640 1645 CCA GAG TTC TCA ATC TAT CGC GGC ATG ATC CCA CCA CGT ACA CCA TGC 4992 Pro Glu Phe Ser Ile Tyr Arg Gly Met Ile Pro Pro Arg Thr Pro Cys 1650 1655 1660 GGT GAC TTA CAA GTG ACC ACA CGT GTG ATT GAA GTT AAC GGT AAG CGT 5040 Gly Asp Leu Gln Val Thr Thr Arg Val Ile Glu Val Asn Gly Lys Arg 1665 1670 1675 1680 GGC GAC TTT AAA AAG CCA TCA TCG TGT ATC GCT GAA TAT GAA GTG CCT 5088 Gly Asp Phe Lys Lys Pro Ser Ser Cys Ile Ala Glu Tyr Glu Val Pro 1685 1690 1695 GCA GAT GCG TGG TAT TTC GAT AAA AAC AGC CAC GGC GCA GTG ATG CCA 5136 Ala Asp Ala Trp Tyr Phe Asp Lys Asn Ser His Gly Ala Val Met Pro 1700 1705 1710 TAT TCA ATT TTA ATG GAG ATC TCA CTG CAA CCT AAC GGC TTT ATC TCA 5184 Tyr Ser Ile Leu Met Glu Ile Ser Leu Gln Pro Asn Gly Phe Ile Ser 1715 1720 1725 GGT TAC ATG GGC ACA ACC CTA GGC TTC CCT GGC CTT GAG CTG TTC TTC 5232 Gly Tyr Met Gly Thr Thr Leu Gly Phe Pro Gly Leu Glu Leu Phe Phe 1730 1735 1740 CGT AAC TTA GAC GGT AGC GGT GAG TTA CTA CGT GAA GTA GAT TTA CGT 5280 Arg Asn Leu Asp Gly Ser Gly Glu Leu Leu Arg Glu Val Asp Leu Arg 1745 1750 1755 1760 GGT AAA ACC ATC CGT AAC GAC TCA CGT TTA TTA TCA ACA GTG ATG GCC 5328 Gly Lys Thr Ile Arg Asn Asp Ser Arg Leu Leu Ser Thr Val Met Ala 1765 1770 1775 GGC ACT AAC ATC ATC CAA AGC TTT AGC TTC GAG CTA AGC ACT GAC GGT 5376 Gly Thr Asn Ile Ile Gln Ser Phe Ser Phe Glu Leu Ser Thr Asp Gly 1780 1785 1790 GAG CCT TTC TAT CGC GGC ACT GCG GTA TTT GGC TAT TTT AAA GGT GAC 5424 Glu Pro Phe Tyr Arg Gly Thr Ala Val Phe Gly Tyr Phe Lys Gly Asp 1795 1800 1805 GCA CTT AAA GAT CAG CTA GGC CTA GAT AAC GGT AAA GTC ACT CAG CCA 5472 Ala Leu Lys Asp Gln Leu Gly Leu Asp Asn Gly Lys Val Thr Gln Pro 1810 1815 1820 TGG CAT GTA GCT AAC GGC GTT GCT GCA AGC ACT AAG GTG AAC CTG CTT 5520 Trp His Val Ala Asn Gly Val Ala Ala Ser Thr Lys Val Asn Leu Leu 1825 1830 1835 1840 GAT AAG AGC TGC CGT CAC TTT AAT GCG CCA GCT AAC CAG CCA CAC TAT 5568 Asp Lys Ser Cys Arg His Phe Asn Ala Pro Ala Asn Gln Pro His Tyr 1845 1850 1855 CGT CTA GCC GGT GGT CAG CTG AAC TTT ATC GAC AGT GTT GAA ATT GTT 5616 Arg Leu Ala Gly Gly Gln Leu Asn Phe Ile Asp Ser Val Glu Ile Val 1860 1865 1870 GAT AAT GGC GGC ACC GAA GGT TTA GGT TAC TTG TAT GCC GAG CGC ACC 5664 Asp Asn Gly Gly Thr Glu Gly Leu Gly Tyr Leu Tyr Ala Glu Arg Thr 1875 1880 1885 ATT GAC CCA AGT GAT TGG TTC TTC CAG TTC CAC TTC CAC CAA GAT CCG 5712 Ile Asp Pro Ser Asp Trp Phe Phe Gln Phe His Phe His Gln Asp Pro 1890 1895 1900 GTT ATG CCA GGC TCC TTA GGT GTT GAA GCA ATT ATT GAA ACC ATG CAA 5760 Val Met Pro Gly Ser Leu Gly Val Glu Ala Ile Ile Glu Thr Met Gln 1905 1910 1915 1920 GCT TAC GCT ATT AGT AAA GAC TTG GGC GCA GAT TTC AAA AAT CCT AAG 5808 Ala Tyr Ala Ile Ser Lys Asp Leu Gly Ala Asp Phe Lys Asn Pro Lys 1925 1930 1935 TTT GGT CAG ATT TTA TCG AAC ATC AAG TGG AAG TAT CGC GGT CAA ATC 5856 Phe Gly Gln Ile Leu Ser Asn Ile Lys Trp Lys Tyr Arg Gly Gln Ile 1940 1945 1950 AAT CCG CTG AAC AAG CAG ATG TCT ATG GAT GTC AGC ATT ACT TCA ATC 5904 Asn Pro Leu Asn Lys Gln Met Ser Met Asp Val Ser Ile Thr Ser Ile 1955 1960 1965 AAA GAT GAA GAC GGT AAG AAA GTC ATC ACA GGT AAT GCC AGC TTG AGT 5952 Lys Asp Glu Asp Gly Lys Lys Val Ile Thr Gly Asn Ala Ser Leu Ser 1970 1975 1980 AAA GAT GGT CTG CGC ATA TAC GAG GTC TTC GAT ATA GCT ATC AGC ATC 6000 Lys Asp Gly Leu Arg Ile Tyr Glu Val Phe Asp Ile Ala Ile Ser Ile 1985 1990 1995 2000 GAA GAA TCT GTA 6012 Glu Glu Ser Val
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG TCA TTA CCA GAC AAT GCT TCT AAC CAC CTT TCT GCC AAC CAG AAA 48 Met Ser Leu Pro Asp Asn Ala Ser Asn His Leu Ser Ala Asn Gln Lys 1 5 10 15 GGC GCA TCT CAG GCA AGT AAA ACC AGT AAG CAA AGC AAA ATC GCC ATT 96 Gly Ala Ser Gln Ala Ser Lys Thr Ser Lys Gln Ser Lys Ile Ala Ile 20 25 30 GTC GGT TTA GCC ACT CTG TAT CCA GAC GCT AAA ACC CCG CAA GAA TTT 144 Val Gly Leu Ala Thr Leu Tyr Pro Asp Ala Lys Thr Pro Gln Glu Phe 35 40 45 TGG CAG AAT TTG CTG GAT AAA CGC GAC TCT CGC AGC ACC TTA ACT AAC 192 Trp Gln Asn Leu Leu Asp Lys Arg Asp Ser Arg Ser Thr Leu Thr Asn 50 55 60 GAA AAA CTC GGC GCT AAC AGC CAA GAT TAT CAA GGT GTG CAA GGC CAA 240 Glu Lys Leu Gly Ala Asn Ser Gln Asp Tyr Gln Gly Val Gln Gly Gln 65 70 75 80 TCT GAC CGT TTT TAT TGT AAT AAA GGC GGC TAC ATT GAG AAC TTC AGC 288 Ser Asp Arg Phe Tyr Cys Asn Lys Gly Gly Tyr Ile Glu Asn Phe Ser 85 90 95 TTT AAT GCT GCA GGC TAC AAA TTG CCG GAG CAA AGC TTA AAT GGC TTG 336 Phe Asn Ala Ala Gly Tyr Lys Leu Pro Glu Gln Ser Leu Asn Gly Leu 100 105 110 GAC GAC AGC TTC CTT TGG GCG CTC GAT ACT AGC CGT AAC GCA CTA ATT 384 Asp Asp Ser Phe Leu Trp Ala Leu Asp Thr Ser Arg Asn Ala Leu Ile 115 120 125 GAT GCT GGT ATT GAT ATC AAC GGC GCT GAT TTA AGC CGC GCA GGT GTA 432 Asp Ala Gly Ile Asp Ile Asn Gly Ala Asp Leu Ser Arg Ala Gly Val 130 135 140 GTC ATG GGC GCG CTG TCG TTC CCA ACT ACC CGC TCA AAC GAT CTG TTT 480 Val Met Gly Ala Leu Ser Phe Pro Thr Thr Arg Ser Asn Asp Leu Phe 145 150 155 160 TTG CCA ATT TAT CAC AGC GCC GTT GAA AAA GCC CTG CAA GAT AAA CTA 528 Leu Pro Ile Tyr His Ser Ala Val Glu Lys Ala Leu Gln Asp Lys Leu 165 170 175 GGC GTA AAG GCA TTT AAG CTA AGC CCA ACT AAT GCT CAT ACC GCT CGC 576 Gly Val Lys Ala Phe Lys Leu Ser Pro Thr Asn Ala His Thr Ala Arg 180 185 190 GCG GCA AAT GAG AGC AGC CTA AAT GCA GCC AAT GGT GCC ATT GCC CAT 624 Ala Ala Asn Glu Ser Ser Leu Asn Ala Ala Asn Gly Ala Ile Ala His 195 200 205 AAC AGC TCA AAA GTG GTG GCC GAT GCA CTT GGC CTT GGC GGC GCA CAA 672 Asn Ser Ser Lys Val Val Ala Asp Ala Leu Gly Leu Gly Gly Ala Gln 210 215 220 CTA AGC CTA GAT GCT GCC TGT GCT AGT TCG GTT TAC TCA TTA AAG CTT 720 Leu Ser Leu Asp Ala Ala Cys Ala Ser Ser Val Tyr Ser Leu Lys Leu 225 230 235 240 GCC TGC GAT TAC CTA AGC ACT GGC AAA GCC GAT ATC ATG CTA GCA GGC 768 Ala Cys Asp Tyr Leu Ser Thr Gly Lys Ala Asp Ile Met Leu Ala Gly 245 250 255 GCA GTA TCT GGC GCG GAT CCT TTC TTT ATT AAT ATG GGA TTC TCA ATC 816 Ala Val Ser Gly Ala Asp Pro Phe Phe Ile Asn Met Gly Phe Ser Ile 260 265 270 TTC CAC GCC TAC CCA GAC CAT GGT ATC TCA GTA CCG TTT GAT GCC AGC 864 Phe His Ala Tyr Pro Asp His Gly Ile Ser Val Pro Phe Asp Ala Ser 275 280 285 AGT AAA GGT TTG TTT GCT GGC GAA GGC GCT GGC GTA TTA GTG CTT AAA 912 Ser Lys Gly Leu Phe Ala Gly Glu Gly Ala Gly Val Leu Val Leu Lys 290 295 300 CGT CTT GAA GAT GCC GAG CGC GAC AAT GAC AAA ATC TAT GCG GTT GTT 960 Arg Leu Glu Asp Ala Glu Arg Asp Asn Asp Lys Ile Tyr Ala Val Val 305 310 315 320 AGC GGC GTA GGT CTA TCA AAC GAC GGT AAA GGC CAG TTT GTA TTA AGC 1008 Ser Gly Val Gly Leu Ser Asn Asp Gly Lys Gly Gln Phe Val Leu Ser 325 330 335 CCT AAT CCA AAA GGT CAG GTG AAG GCC TTT GAA CGT GCT TAT GCT GCC 1056 Pro Asn Pro Lys Gly Gln Val Lys Ala Phe Glu Arg Ala Tyr Ala Ala 340 345 350 AGT GAC ATT GAG CCA AAA GAC ATT GAA GTG ATT GAG TGC CAC GCA ACA 1104 Ser Asp Ile Glu Pro Lys Asp Ile Glu Val Ile Glu Cys His Ala Thr 355 360 365 GGC ACA CCG CTT GGC GAT AAA ATT GAG CTC ACT TCA ATG GAA ACC TTC 1152 Gly Thr Pro Leu Gly Asp Lys Ile Glu Leu Thr Ser Met Glu Thr Phe 370 375 380 TTT GAA GAC AAG CTG CAA GGC ACC GAT GCA CCG TTA ATT GGC TCA GCT 1200 Phe Glu Asp Lys Leu Gln Gly Thr Asp Ala Pro Leu Ile Gly Ser Ala 385 390 395 400 AAG TCT AAC TTA GGC CAC CTA TTA ACT GCA GCG CAT GCG GGG ATC ATG 1248 Lys Ser Asn Leu Gly His Leu Leu Thr Ala Ala His Ala Gly Ile Met 405 410 415 AAG ATG ATC TTC GCC ATG AAA GAA GGT TAC CTG CCG CCA AGT ATC AAT 1296 Lys Met Ile Phe Ala Met Lys Glu Gly Tyr Leu Pro Pro Ser Ile Asn 420 425 430 ATT AGT GAT GCT ATC GCT TCG CCG AAA AAA CTC TTC GGT AAA CCA ACC 1344 Ile Ser Asp Ala Ile Ala Ser Pro Lys Lys Leu Phe Gly Lys Pro Thr 435 440 445 CTG CCT AGC ATG GTT CAA GGC TGG CCA GAT AAG CCA TCG AAT AAT CAT 1392 Leu Pro Ser Met Val Gln Gly Trp Pro Asp Lys Pro Ser Asn Asn His 450 455 460 TTT GGT GTA AGA ACC CGT CAC GCA GGC GTA TCG GTA TTT GGC TTT GGT 1440 Phe Gly Val Arg Thr Arg His Ala Gly Val Ser Val Phe Gly Phe Gly 465 470 475 480 GGC TGT AAC GCC CAT CTG TTG CTT GAG TCA TAC AAC GGC AAA GGA ACA 1488 Gly Cys Asn Ala His Leu Leu Leu Glu Ser Tyr Asn Gly Lys Gly Thr 485 490 495 GTA AAG GCA GAA GCC ACT CAA GTA CCG CGT CAA GCT GAG CCG CTA AAA 1536 Val Lys Ala Glu Ala Thr Gln Val Pro Arg Gln Ala Glu Pro Leu Lys 500 505 510 GTG GTT GGC CTT GCC TCG CAC TTT GGG CCT CTT AGC AGC ATT AAT GCA 1584 Val Val Gly Leu Ala Ser His Phe Gly Pro Leu Ser Ser Ile Asn Ala 515 520 525 CTC AAC AAT GCT GTG ACC CAA GAT GGG AAT GGC TTT ATC GAA CTG CCG 1632 Leu Asn Asn Ala Val Thr Gln Asp Gly Asn Gly Phe Ile Glu Leu Pro 530 535 540 AAA AAG CGC TGG AAA GGC CTT GAA AAG CAC AGT GAA CTG TTA GCT GAA 1680 Lys Lys Arg Trp Lys Gly Leu Glu Lys His Ser Glu Leu Leu Ala Glu 545 550 555 560 TTT GGC TTA GCA TCT GCG CCA AAA GGT GCT TAT GTT GAT AAC TTC GAG 1728 Phe Gly Leu Ala Ser Ala Pro Lys Gly Ala Tyr Val Asp Asn Phe Glu 565 570 575 CTG GAC TTT TTA CGC TTT AAA CTG CCG CCA AAC GAA GAT GAC CGT TTG 1776 Leu Asp Phe Leu Arg Phe Lys Leu Pro Pro Asn Glu Asp Asp Arg Leu 580 585 590 ATC TCA CAG CAG CTA ATG CTA ATG CGA GTA ACA GAC GAA GCC ATT CGT 1824 Ile Ser Gln Gln Leu Met Leu Met Arg Val Thr Asp Glu Ala Ile Arg 595 600 605 GAT GCC AAG CTT GAG CCG GGG CAA AAA GTA GCT GTA TTA GTG GCA ATG 1872 Asp Ala Lys Leu Glu Pro Gly Gln Lys Val Ala Val Leu Val Ala Met 610 615 620 GAA ACT GAG CTT GAA CTG CAT CAG TTC CGC GGC CGG GTT AAC TTG CAT 1920 Glu Thr Glu Leu Glu Leu His Gln Phe Arg Gly Arg Val Asn Leu His 625 630 635 640 ACT CAA TTA GCG CAA AGT CTT GCC GCC ATG GGC GTG AGT TTA TCA ACG 1968 Thr Gln Leu Ala Gln Ser Leu Ala Ala Met Gly Val Ser Leu Ser Thr 645 650 655 GAT GAA TAC CAA GCG CTT GAA GCC ATC GCC ATG GAC AGC GTG CTT GAT 2016 Asp Glu Tyr Gln Ala Leu Glu Ala Ile Ala Met Asp Ser Val Leu Asp 660 665 670 GCT GCC AAG CTC AAT CAG TAC ACC AGC TTT ATT GGT AAT ATT ATG GCG 2064 Ala Ala Lys Leu Asn Gln Tyr Thr Ser Phe Ile Gly Asn Ile Met Ala 675 680 685 TCA CGC GTG GCG TCA CTA TGG GAC TTT AAT GGC CCA GCC TTC ACT ATT 2112 Ser Arg Val Ala Ser Leu Trp Asp Phe Asn Gly Pro Ala Phe Thr Ile 690 695 700 TCA GCA GCA GAG CAA TCT GTG AGC CGC TGT ATC GAT GTG GCG CAA AAC 2160 Ser Ala Ala Glu Gln Ser Val Ser Arg Cys Ile Asp Val Ala Gln Asn 705 710 715 720 CTC ATC ATG GAG GAT AAC CTA GAT GCG GTG GTG ATT GCA GCG GTC GAT 2208 Leu Ile Met Glu Asp Asn Leu Asp Ala Val Val Ile Ala Ala Val Asp 725 730 735 CTC TCT GGT AGC TTT GAG CAA GTC ATT CTT AAA AAT GCC ATT GCA CCT 2256 Leu Ser Gly Ser Phe Glu Gln Val Ile Leu Lys Asn Ala Ile Ala Pro 740 745 750 GTA GCC ATT GAG CCA AAC CTC GAA GCA AGC CTT AAT CCA ACA TCA GCA 2304 Val Ala Ile Glu Pro Asn Leu Glu Ala Ser Leu Asn Pro Thr Ser Ala 755 760 765 AGC TGG AAT GTC GGT GAA GGT GCT GGC GCG GTC GTG CTT GTT AAA AAT 2352 Ser Trp Asn Val Gly Glu Gly Ala Gly Ala Val Val Leu Val Lys Asn 770 775 780 GAA GCT ACA TCG GGC TGC TCA TAC GGC CAA ATT GAT GCA CTT GGC TTT 2400 Glu Ala Thr Ser Gly Cys Ser Tyr Gly Gln Ile Asp Ala Leu Gly Phe 785 790 795 800 GCT AAA ACT GCC GAA ACA GCG TTG GCT ACC GAC AAG CTA CTG AGC CAA 2448 Ala Lys Thr Ala Glu Thr Ala Leu Ala Thr Asp Lys Leu Leu Ser Gln 805 810 815 ACT GCC ACA GAC TTT AAT AAG GTT AAA GTG ATT GAA ACT ATG GCA GCG 2496 Thr Ala Thr Asp Phe Asn Lys Val Lys Val Ile Glu Thr Met Ala Ala 820 825 830 CCT GCT AGC CAA ATT CAA TTA GCG CCA ATA GTT AGC TCT CAA GTG ACT 2544 Pro Ala Ser Gln Ile Gln Leu Ala Pro Ile Val Ser Ser Gln Val Thr 835 840 845 CAC ACT GCT GCA GAG CAG CGT GTT GGT CAC TGC TTT GCT GCA GCG GGT 2592 His Thr Ala Ala Glu Gln Arg Val Gly His Cys Phe Ala Ala Ala Gly 850 855 860 ATG GCA AGC CTA TTA CAC GGC TTA CTT AAC TTA AAT ACT GTA GCC CAA 2640 Met Ala Ser Leu Leu His Gly Leu Leu Asn Leu Asn Thr Val Ala Gln 865 870 875 880 ACC AAT AAA GCC AAT TGC GCG CTT ATC AAC AAT ATC AGT GAA AAC CAA 2688 Thr Asn Lys Ala Asn Cys Ala Leu Ile Asn Asn Ile Ser Glu Asn Gln 885 890 895 TTA TCA CAG CTG TTG ATT AGC CAA ACA GCG AGC GAA CAA CAA GCA TTA 2736 Leu Ser Gln Leu Leu Ile Ser Gln Thr Ala Ser Glu Gln Gln Ala Leu 900 905 910 ACC GCG CGT TTA AGC AAT GAG CTT AAA TCC GAT GCT AAA CAC CAA CTG 2784 Thr Ala Arg Leu Ser Asn Glu Leu Lys Ser Asp Ala Lys His Gln Leu 915 920 925 GTT AAG CAA GTC ACC TTA GGT GGC CGT GAT ATC TAC CAG CAT ATT GTT 2832 Val Lys Gln Val Thr Leu Gly Gly Arg Asp Ile Tyr Gln His Ile Val 930 935 940 GAT ACA CCG CTT GCA AGC CTT GAA AGC ATT ACT CAG AAA TTG GCG CAA 2880 Asp Thr Pro Leu Ala Ser Leu Glu Ser Ile Thr Gln Lys Leu Ala Gln 945 950 955 960 GCG ACA GCA TCG ACA GTG GTC AAC CAA GTT AAA CCT ATT AAG GCC GCT 2928 Ala Thr Ala Ser Thr Val Val Asn Gln Val Lys Pro Ile Lys Ala Ala 965 970 975 GGC TCA GTC GAA ATG GCT AAC TCA TTC GAA ACG GAA AGC TCA GCA GAG 2976 Gly Ser Val Glu Met Ala Asn Ser Phe Glu Thr Glu Ser Ser Ala Glu 980 985 990 CCA CAA ATA ACA ATT GCA GCA CAA CAG ACT GCA AAC ATT GGC GTC ACC 3024 Pro Gln Ile Thr Ile Ala Ala Gln Gln Thr Ala Asn Ile Gly Val Thr 995 1000 1005 GCT CAG GCA ACC AAA CGT GAA TTA GGT ACC CCA CCA ATG ACA ACA AAT 3072 Ala Gln Ala Thr Lys Arg Glu Leu Gly Thr Pro Pro Met Thr Thr Asn 1010 1015 1020 ACC ATT GCT AAT ACA GCA AAT AAT TTA GAC AAG ACT CTT GAG ACT GTT 3120 Thr Ile Ala Asn Thr Ala Asn Asn Leu Asp Lys Thr Leu Glu Thr Val 1025 1030 1035 1040 GCT GGC AAT ACT GTT GCT AGC AAG GTT GGC TCT GGC GAC ATA GTC AAT 3168 Ala Gly Asn Thr Val Ala Ser Lys Val Gly Ser Gly Asp Ile Val Asn 1045 1050 1055 TTT CAA CAG AAC CAA CAA TTG GCT CAA CAA GCT CAC CTC GCC TTT CTT 3216 Phe Gln Gln Asn Gln Gln Leu Ala Gln Gln Ala His Leu Ala Phe Leu 1060 1065 1070 GAA AGC CGC AGT GCG GGT ATG AAG GTG GCT GAT GCT TTA TTG AAG CAA 3264 Glu Ser Arg Ser Ala Gly Met Lys Val Ala Asp Ala Leu Leu Lys Gln 1075 1080 1085 CAG CTA GCT CAA GTA ACA GGC CAA ACT ATC GAT AAT CAG GCC CTC GAT 3312 Gln Leu Ala Gln Val Thr Gly Gln Thr Ile Asp Asn Gln Ala Leu Asp 1090 1095 1100 ACT CAA GCC GTC GAT ACT CAA ACA AGC GAG AAT GTA GCG ATT GCC GCA 3360 Thr Gln Ala Val Asp Thr Gln Thr Ser Glu Asn Val Ala Ile Ala Ala 1105 1110 1115 1120 GAA TCA CCA GTT CAA GTT ACA ACA CCT GTT CAA GTT ACA ACA CCT GTT 3408 Glu Ser Pro Val Gln Val Thr Thr Pro Val Gln Val Thr Thr Pro Val 1125 1130 1135 CAA ATC AGT GTT GTG GAG TTA AAA CCA GAT CAC GCT AAT GTG CCA CCA 3456 Gln Ile Ser Val Val Glu Leu Lys Pro Asp His Ala Asn Val Pro Pro 1140 1145 1150 TAC ACG CCG CCA GTG CCT GCA TTA AAG CCG TGT ATC TGG AAC TAT GCC 3504 Tyr Thr Pro Pro Val Pro Ala Leu Lys Pro Cys Ile Trp Asn Tyr Ala 1155 1160 1165 GAT TTA GTT GAG TAC GCA GAA GGC GAT ATC GCC AAG GTA TTT GGC AGT 3552 Asp Leu Val Glu Tyr Ala Glu Gly Asp Ile Ala Lys Val Phe Gly Ser 1170 1175 1180 GAT TAT GCC ATT ATC GAC AGC TAC TCG CGC CGC GTA CGT CTA CCG ACC 3600 Asp Tyr Ala Ile Ile Asp Ser Tyr Ser Arg Arg Val Arg Leu Pro Thr 1185 1190 1195 1200 ACT GAC TAC CTG TTG GTA TCG CGC GTG ACC AAA CTT GAT GCG ACC ATC 3648 Thr Asp Tyr Leu Leu Val Ser Arg Val Thr Lys Leu Asp Ala Thr Ile 1205 1210 1215 AAT CAA TTT AAG CCA TGC TCA ATG ACC ACT GAG TAC GAC ATC CCT GTT 3696 Asn Gln Phe Lys Pro Cys Ser Met Thr Thr Glu Tyr Asp Ile Pro Val 1220 1225 1230 GAT GCG CCG TAC TTA GTA GAC GGA CAA ATC CCT TGG GCG GTA GCA GTA 3744 Asp Ala Pro Tyr Leu Val Asp Gly Gln Ile Pro Trp Ala Val Ala Val 1235 1240 1245 GAA TCA GGC CAA TGT GAC TTG ATG CTT ATT AGC TAT CTC GGT ATC GAC 3792 Glu Ser Gly Gln Cys Asp Leu Met Leu Ile Ser Tyr Leu Gly Ile Asp 1250 1255 1260 TTT GAG AAC AAA GGC GAG CGG GTT TAT CGA CTA CTC GAT TGT ACC CTC 3840 Phe Glu Asn Lys Gly Glu Arg Val Tyr Arg Leu Leu Asp Cys Thr Leu 1265 1270 1275 1280 ACC TTC CTA GGC GAC TTG CCA CGT GGC GGA GAT ACC CTA CGT TAC GAC 3888 Thr Phe Leu Gly Asp Leu Pro Arg Gly Gly Asp Thr Leu Arg Tyr Asp 1285 1290 1295 ATT AAG ATC AAT AAC TAT GCT CGC AAC GGC GAC ACC CTG CTG TTC TTC 3936 Ile Lys Ile Asn Asn Tyr Ala Arg Asn Gly Asp Thr Leu Leu Phe Phe 1300 1305 1310 TTC TCG TAT GAG TGT TTT GTT GGC GAC AAG ATG ATC CTC AAG ATG GAT 3984 Phe Ser Tyr Glu Cys Phe Val Gly Asp Lys Met Ile Leu Lys Met Asp 1315 1320 1325 GGC GGC TGC GCT GGC TTC TTC ACT GAT GAA GAG CTT GCC GAC GGT AAA 4032 Gly Gly Cys Ala Gly Phe Phe Thr Asp Glu Glu Leu Ala Asp Gly Lys 1330 1335 1340 GGC GTG ATT CGC ACA GAA GAA GAG ATT AAA GCT CGC AGC CTA GTG CAA 4080 Gly Val Ile Arg Thr Glu Glu Glu Ile Lys Ala Arg Ser Leu Val Gln 1345 1350 1355 1360 AAG CAA CGC TTT AAT CCG TTA CTA GAT TGT CCT AAA ACC CAA TTT AGT 4128 Lys Gln Arg Phe Asn Pro Leu Leu Asp Cys Pro Lys Thr Gln Phe Ser 1365 1370 1375 TAT GGT GAT ATT CAT AAG CTA TTA ACT GCT GAT ATT GAG GGT TGT TTT 4176 Tyr Gly Asp Ile His Lys Leu Leu Thr Ala Asp Ile Glu Gly Cys Phe 1380 1385 1390 GGC CCA AGC CAC AGT GGC GTC CAC CAG CCG TCA CTT TGT TTC GCA TCT 4224 Gly Pro Ser His Ser Gly Val His Gln Pro Ser Leu Cys Phe Ala Ser 1395 1400 1405 GAA AAA TTC TTG ATG ATT GAA CAA GTC AGC AAG GTT GAT CGC ACT GGC 4272 Glu Lys Phe Leu Met Ile Glu Gln Val Ser Lys Val Asp Arg Thr Gly 1410 1415 1420 GGT ACT TGG GGA CTT GGC TTA ATT GAG GGT CAT AAG CAG CTT GAA GCA 4320 Gly Thr Trp Gly Leu Gly Leu Ile Glu Gly His Lys Gln Leu Glu Ala 1425 1430 1435 1440 GAC CAC TGG TAC TTC CCA TGT CAT TTC AAG GGC GAC CAA GTG ATG GCT 4368 Asp His Trp Tyr Phe Pro Cys His Phe Lys Gly Asp Gln Val Met Ala 1445 1450 1455 GGC TCG CTA ATG GCT GAA GGT TGT GGC CAG TTA TTG CAG TTC TAT ATG 4416 Gly Ser Leu Met Ala Glu Gly Cys Gly Gln Leu Leu Gln Phe Tyr Met 1460 1465 1470 CTG CAC CTT GGT ATG CAT ACC CAA ACT AAA AAT GGT CGT TTC CAA CCT 4464 Leu His Leu Gly Met His Thr Gln Thr Lys Asn Gly Arg Phe Gln Pro 1475 1480 1485 CTT GAA AAC GCC TCA CAG CAA GTA CGC TGT CGC GGT CAA GTG CTG CCA 4512 Leu Glu Asn Ala Ser Gln Gln Val Arg Cys Arg Gly Gln Val Leu Pro 1490 1495 1500 CAA TCA GGC GTG CTA ACT TAC CGT ATG GAA GTG ACT GAA ATC GGT TTC 4560 Gln Ser Gly Val Leu Thr Tyr Arg Met Glu Val Thr Glu Ile Gly Phe 1505 1510 1515 1520 AGT CCA CGC CCA TAT GCT AAA GCT AAC ATC GAT ATC TTG CTT AAT GGC 4608 Ser Pro Arg Pro Tyr Ala Lys Ala Asn Ile Asp Ile Leu Leu Asn Gly 1525 1530 1535 AAA GCG GTA GTG GAT TTC CAA AAC CTA GGG GTG ATG ATA AAA GAG GAA 4656 Lys Ala Val Val Asp Phe Gln Asn Leu Gly Val Met Ile Lys Glu Glu 1540 1545 1550 GAT GAG TGT ACT CGT TAT CCA CTT TTG ACT GAA TCA ACA ACG GCT AGC 4704 Asp Glu Cys Thr Arg Tyr Pro Leu Leu Thr Glu Ser Thr Thr Ala Ser 1555 1560 1565 ACT GCA CAA GTA AAC GCT CAA ACA AGT GCG AAA AAG GTA TAC AAG CCA 4752 Thr Ala Gln Val Asn Ala Gln Thr Ser Ala Lys Lys Val Tyr Lys Pro 1570 1575 1580 GCA TCA GTC AAT GCG CCA TTA ATG GCA CAA ATT CCT GAT CTG ACT AAA 4800 Ala Ser Val Asn Ala Pro Leu Met Ala Gln Ile Pro Asp Leu Thr Lys 1585 1590 1595 1600 GAG CCA AAC AAG GGC GTT ATT CCG ATT TCC CAT GTT GAA GCA CCA ATT 4848 Glu Pro Asn Lys Gly Val Ile Pro Ile Ser His Val Glu Ala Pro Ile 1605 1610 1615 ACG CCA GAC TAC CCG AAC CGT GTA CCT GAT ACA GTG CCA TTC ACG CCG 4896 Thr Pro Asp Tyr Pro Asn Arg Val Pro Asp Thr Val Pro Phe Thr Pro 1620 1625 1630 TAT CAC ATG TTT GAG TTT GCT ACA GGC AAT ATC GAA AAC TGT TTC GGG 4944 Tyr His Met Phe Glu Phe Ala Thr Gly Asn Ile Glu Asn Cys Phe Gly 1635 1640 1645 CCA GAG TTC TCA ATC TAT CGC GGC ATG ATC CCA CCA CGT ACA CCA TGC 4992 Pro Glu Phe Ser Ile Tyr Arg Gly Met Ile Pro Pro Arg Thr Pro Cys 1650 1655 1660 GGT GAC TTA CAA GTG ACC ACA CGT GTG ATT GAA GTT AAC GGT AAG CGT 5040 Gly Asp Leu Gln Val Thr Thr Arg Val Ile Glu Val Asn Gly Lys Arg 1665 1670 1675 1680 GGC GAC TTT AAA AAG CCA TCA TCG TGT ATC GCT GAA TAT GAA GTG CCT 5088 Gly Asp Phe Lys Lys Pro Ser Ser Cys Ile Ala Glu Tyr Glu Val Pro 1685 1690 1695 GCA GAT GCG TGG TAT TTC GAT AAA AAC AGC CAC GGC GCA GTG ATG CCA 5136 Ala Asp Ala Trp Tyr Phe Asp Lys Asn Ser His Gly Ala Val Met Pro 1700 1705 1710 TAT TCA ATT TTA ATG GAG ATC TCA CTG CAA CCT AAC GGC TTT ATC TCA 5184 Tyr Ser Ile Leu Met Glu Ile Ser Leu Gln Pro Asn Gly Phe Ile Ser 1715 1720 1725 GGT TAC ATG GGC ACA ACC CTA GGC TTC CCT GGC CTT GAG CTG TTC TTC 5232 Gly Tyr Met Gly Thr Thr Leu Gly Phe Pro Gly Leu Glu Leu Phe Phe 1730 1735 1740 CGT AAC TTA GAC GGT AGC GGT GAG TTA CTA CGT GAA GTA GAT TTA CGT 5280 Arg Asn Leu Asp Gly Ser Gly Glu Leu Leu Arg Glu Val Asp Leu Arg 1745 1750 1755 1760 GGT AAA ACC ATC CGT AAC GAC TCA CGT TTA TTA TCA ACA GTG ATG GCC 5328 Gly Lys Thr Ile Arg Asn Asp Ser Arg Leu Leu Ser Thr Val Met Ala 1765 1770 1775 GGC ACT AAC ATC ATC CAA AGC TTT AGC TTC GAG CTA AGC ACT GAC GGT 5376 Gly Thr Asn Ile Ile Gln Ser Phe Ser Phe Glu Leu Ser Thr Asp Gly 1780 1785 1790 GAG CCT TTC TAT CGC GGC ACT GCG GTA TTT GGC TAT TTT AAA GGT GAC 5424 Glu Pro Phe Tyr Arg Gly Thr Ala Val Phe Gly Tyr Phe Lys Gly Asp 1795 1800 1805 GCA CTT AAA GAT CAG CTA GGC CTA GAT AAC GGT AAA GTC ACT CAG CCA 5472 Ala Leu Lys Asp Gln Leu Gly Leu Asp Asn Gly Lys Val Thr Gln Pro 1810 1815 1820 TGG CAT GTA GCT AAC GGC GTT GCT GCA AGC ACT AAG GTG AAC CTG CTT 5520 Trp His Val Ala Asn Gly Val Ala Ala Ser Thr Lys Val Asn Leu Leu 1825 1830 1835 1840 GAT AAG AGC TGC CGT CAC TTT AAT GCG CCA GCT AAC CAG CCA CAC TAT 5568 Asp Lys Ser Cys Arg His Phe Asn Ala Pro Ala Asn Gln Pro His Tyr 1845 1850 1855 CGT CTA GCC GGT GGT CAG CTG AAC TTT ATC GAC AGT GTT GAA ATT GTT 5616 Arg Leu Ala Gly Gly Gln Leu Asn Phe Ile Asp Ser Val Glu Ile Val 1860 1865 1870 GAT AAT GGC GGC ACC GAA GGT TTA GGT TAC TTG TAT GCC GAG CGC ACC 5664 Asp Asn Gly Gly Thr Glu Gly Leu Gly Tyr Leu Tyr Ala Glu Arg Thr 1875 1880 1885 ATT GAC CCA AGT GAT TGG TTC TTC CAG TTC CAC TTC CAC CAA GAT CCG 5712 Ile Asp Pro Ser Asp Trp Phe Phe Gln Phe His Phe His Gln Asp Pro 1890 1895 1900 GTT ATG CCA GGC TCC TTA GGT GTT GAA GCA ATT ATT GAA ACC ATG CAA 5760 Val Met Pro Gly Ser Leu Gly Val Glu Ala Ile Ile Glu Thr Met Gln 1905 1910 1915 1920 GCT TAC GCT ATT AGT AAA GAC TTG GGC GCA GAT TTC AAA AAT CCT AAG 5808 Ala Tyr Ala Ile Ser Lys Asp Leu Gly Ala Asp Phe Lys Asn Pro Lys 1925 1930 1935 TTT GGT CAG ATT TTA TCG AAC ATC AAG TGG AAG TAT CGC GGT CAA ATC 5856 Phe Gly Gln Ile Leu Ser Asn Ile Lys Trp Lys Tyr Arg Gly Gln Ile 1940 1945 1950 AAT CCG CTG AAC AAG CAG ATG TCT ATG GAT GTC AGC ATT ACT TCA ATC 5904 Asn Pro Leu Asn Lys Gln Met Ser Met Asp Val Ser Ile Thr Ser Ile 1955 1960 1965 AAA GAT GAA GAC GGT AAG AAA GTC ATC ACA GGT AAT GCC AGC TTG AGT 5952 Lys Asp Glu Asp Gly Lys Lys Val Ile Thr Gly Asn Ala Ser Leu Ser 1970 1975 1980 AAA GAT GGT CTG CGC ATA TAC GAG GTC TTC GAT ATA GCT ATC AGC ATC 6000 Lys Asp Gly Leu Arg Ile Tyr Glu Val Phe Asp Ile Ala Ile Ser Ile 1985 1990 1995 2000 GAA GAA TCT GTA 6012 Glu Glu Ser Val
【００６４】配列番号： １５ 配列の長さ：２００４ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Ser Leu Pro Asp Asn Ala Ser Asn His Leu Ser Ala Asn Gln Lys 1 5 10 15 Gly Ala Ser Gln Ala Ser Lys Thr Ser Lys Gln Ser Lys Ile Ala Ile 20 25 30 Val Gly Leu Ala Thr Leu Tyr Pro Asp Ala Lys Thr Pro Gln Glu Phe 35 40 45 Trp Gln Asn Leu Leu Asp Lys Arg Asp Ser Arg Ser Thr Leu Thr Asn 50 55 60 Glu Lys Leu Gly Ala Asn Ser Gln Asp Tyr Gln Gly Val Gln Gly Gln 65 70 75 80 Ser Asp Arg Phe Tyr Cys Asn Lys Gly Gly Tyr Ile Glu Asn Phe Ser 85 90 95 Phe Asn Ala Ala Gly Tyr Lys Leu Pro Glu Gln Ser Leu Asn Gly Leu 100 105 110 Asp Asp Ser Phe Leu Trp Ala Leu Asp Thr Ser Arg Asn Ala Leu Ile 115 120 125 Asp Ala Gly Ile Asp Ile Asn Gly Ala Asp Leu Ser Arg Ala Gly Val 130 135 140 Val Met Gly Ala Leu Ser Phe Pro Thr Thr Arg Ser Asn Asp Leu Phe 145 150 155 160 Leu Pro Ile Tyr His Ser Ala Val Glu Lys Ala Leu Gln Asp Lys Leu 165 170 175 Gly Val Lys Ala Phe Lys Leu Ser Pro Thr Asn Ala His Thr Ala Arg 180 185 190 Ala Ala Asn Glu Ser Ser Leu Asn Ala Ala Asn Gly Ala Ile Ala His 195 200 205 Asn Ser Ser Lys Val Val Ala Asp Ala Leu Gly Leu Gly Gly Ala Gln 210 215 220 Leu Ser Leu Asp Ala Ala Cys Ala Ser Ser Val Tyr Ser Leu Lys Leu 225 230 235 240 Ala Cys Asp Tyr Leu Ser Thr Gly Lys Ala Asp Ile Met Leu Ala Gly 245 250 255 Ala Val Ser Gly Ala Asp Pro Phe Phe Ile Asn Met Gly Phe Ser Ile 260 265 270 Phe His Ala Tyr Pro Asp His Gly Ile Ser Val Pro Phe Asp Ala Ser 275 280 285 Ser Lys Gly Leu Phe Ala Gly Glu Gly Ala Gly Val Leu Val Leu Lys 290 295 300 Arg Leu Glu Asp Ala Glu Arg Asp Asn Asp Lys Ile Tyr Ala Val Val 305 310 315 320 Ser Gly Val Gly Leu Ser Asn Asp Gly Lys Gly Gln Phe Val Leu Ser 325 330 335 Pro Asn Pro Lys Gly Gln Val Lys Ala Phe Glu Arg Ala Tyr Ala Ala 340 345 350 Ser Asp Ile Glu Pro Lys Asp Ile Glu Val Ile Glu Cys His Ala Thr 355 360 365 Gly Thr Pro Leu Gly Asp Lys Ile Glu Leu Thr Ser Met Glu Thr Phe 370 375 380 Phe Glu Asp Lys Leu Gln Gly Thr Asp Ala Pro Leu Ile Gly Ser Ala 385 390 395 400 Lys Ser Asn Leu Gly His Leu Leu Thr Ala Ala His Ala Gly Ile Met 405 410 415 Lys Met Ile Phe Ala Met Lys Glu Gly Tyr Leu Pro Pro Ser Ile Asn 420 425 430 Ile Ser Asp Ala Ile Ala Ser Pro Lys Lys Leu Phe Gly Lys Pro Thr 435 440 445 Leu Pro Ser Met Val Gln Gly Trp Pro Asp Lys Pro Ser Asn Asn His 450 455 460 Phe Gly Val Arg Thr Arg His Ala Gly Val Ser Val Phe Gly Phe Gly 465 470 475 480 Gly Cys Asn Ala His Leu Leu Leu Glu Ser Tyr Asn Gly Lys Gly Thr 485 490 495 Val Lys Ala Glu Ala Thr Gln Val Pro Arg Gln Ala Glu Pro Leu Lys 500 505 510 Val Val Gly Leu Ala Ser His Phe Gly Pro Leu Ser Ser Ile Asn Ala 515 520 525 Leu Asn Asn Ala Val Thr Gln Asp Gly Asn Gly Phe Ile Glu Leu Pro 530 535 540 Lys Lys Arg Trp Lys Gly Leu Glu Lys His Ser Glu Leu Leu Ala Glu 545 550 555 560 Phe Gly Leu Ala Ser Ala Pro Lys Gly Ala Tyr Val Asp Asn Phe Glu 565 570 575 Leu Asp Phe Leu Arg Phe Lys Leu Pro Pro Asn Glu Asp Asp Arg Leu 580 585 590 Ile Ser Gln Gln Leu Met Leu Met Arg Val Thr Asp Glu Ala Ile Arg 595 600 605 Asp Ala Lys Leu Glu Pro Gly Gln Lys Val Ala Val Leu Val Ala Met 610 615 620 Glu Thr Glu Leu Glu Leu His Gln Phe Arg Gly Arg Val Asn Leu His 625 630 635 640 Thr Gln Leu Ala Gln Ser Leu Ala Ala Met Gly Val Ser Leu Ser Thr 645 650 655 Asp Glu Tyr Gln Ala Leu Glu Ala Ile Ala Met Asp Ser Val Leu Asp 660 665 670 Ala Ala Lys Leu Asn Gln Tyr Thr Ser Phe Ile Gly Asn Ile Met Ala 675 680 685 Ser Arg Val Ala Ser Leu Trp Asp Phe Asn Gly Pro Ala Phe Thr Ile 690 695 700 Ser Ala Ala Glu Gln Ser Val Ser Arg Cys Ile Asp Val Ala Gln Asn 705 710 715 720 Leu Ile Met Glu Asp Asn Leu Asp Ala Val Val Ile Ala Ala Val Asp 725 730 735 Leu Ser Gly Ser Phe Glu Gln Val Ile Leu Lys Asn Ala Ile Ala Pro 740 745 750 Val Ala Ile Glu Pro Asn Leu Glu Ala Ser Leu Asn Pro Thr Ser Ala 755 760 765 Ser Trp Asn Val Gly Glu Gly Ala Gly Ala Val Val Leu Val Lys Asn 770 775 780 Glu Ala Thr Ser Gly Cys Ser Tyr Gly Gln Ile Asp Ala Leu Gly Phe 785 790 795 800 Ala Lys Thr Ala Glu Thr Ala Leu Ala Thr Asp Lys Leu Leu Ser Gln 805 810 815 Thr Ala Thr Asp Phe Asn Lys Val Lys Val Ile Glu Thr Met Ala Ala 820 825 830 Pro Ala Ser Gln Ile Gln Leu Ala Pro Ile Val Ser Ser Gln Val Thr 835 840 845 His Thr Ala Ala Glu Gln Arg Val Gly His Cys Phe Ala Ala Ala Gly 850 855 860 Met Ala Ser Leu Leu His Gly Leu Leu Asn Leu Asn Thr Val Ala Gln 865 870 875 880 Thr Asn Lys Ala Asn Cys Ala Leu Ile Asn Asn Ile Ser Glu Asn Gln 885 890 895 Leu Ser Gln Leu Leu Ile Ser Gln Thr Ala Ser Glu Gln Gln Ala Leu 900 905 910 Thr Ala Arg Leu Ser Asn Glu Leu Lys Ser Asp Ala Lys His Gln Leu 915 920 925 Val Lys Gln Val Thr Leu Gly Gly Arg Asp Ile Tyr Gln His Ile Val 930 935 940 Asp Thr Pro Leu Ala Ser Leu Glu Ser Ile Thr Gln Lys Leu Ala Gln 945 950 955 960 Ala Thr Ala Ser Thr Val Val Asn Gln Val Lys Pro Ile Lys Ala Ala 965 970 975 Gly Ser Val Glu Met Ala Asn Ser Phe Glu Thr Glu Ser Ser Ala Glu 980 985 990 Pro Gln Ile Thr Ile Ala Ala Gln Gln Thr Ala Asn Ile Gly Val Thr 995 1000 1005 Ala Gln Ala Thr Lys Arg Glu Leu Gly Thr Pro Pro Met Thr Thr Asn 1010 1015 1020 Thr Ile Ala Asn Thr Ala Asn Asn Leu Asp Lys Thr Leu Glu Thr Val 1025 1030 1035 1040 Ala Gly Asn Thr Val Ala Ser Lys Val Gly Ser Gly Asp Ile Val Asn 1045 1050 1055 Phe Gln Gln Asn Gln Gln Leu Ala Gln Gln Ala His Leu Ala Phe Leu 1060 1065 1070 Glu Ser Arg Ser Ala Gly Met Lys Val Ala Asp Ala Leu Leu Lys Gln 1075 1080 1085 Gln Leu Ala Gln Val Thr Gly Gln Thr Ile Asp Asn Gln Ala Leu Asp 1090 1095 1100 Thr Gln Ala Val Asp Thr Gln Thr Ser Glu Asn Val Ala Ile Ala Ala 1105 1110 1115 1120 Glu Ser Pro Val Gln Val Thr Thr Pro Val Gln Val Thr Thr Pro Val 1125 1130 1135 Gln Ile Ser Val Val Glu Leu Lys Pro Asp His Ala Asn Val Pro Pro 1140 1145 1150 Tyr Thr Pro Pro Val Pro Ala Leu Lys Pro Cys Ile Trp Asn Tyr Ala 1155 1160 1165 Asp Leu Val Glu Tyr Ala Glu Gly Asp Ile Ala Lys Val Phe Gly Ser 1170 1175 1180 Asp Tyr Ala Ile Ile Asp Ser Tyr Ser Arg Arg Val Arg Leu Pro Thr 1185 1190 1195 1200 Thr Asp Tyr Leu Leu Val Ser Arg Val Thr Lys Leu Asp Ala Thr Ile 1205 1210 1215 Asn Gln Phe Lys Pro Cys Ser Met Thr Thr Glu Tyr Asp Ile Pro Val 1220 1225 1230 Asp Ala Pro Tyr Leu Val Asp Gly Gln Ile Pro Trp Ala Val Ala Val 1235 1240 1245 Glu Ser Gly Gln Cys Asp Leu Met Leu Ile Ser Tyr Leu Gly Ile Asp 1250 1255 1260 Phe Glu Asn Lys Gly Glu Arg Val Tyr Arg Leu Leu Asp Cys Thr Leu 1265 1270 1275 1280 Thr Phe Leu Gly Asp Leu Pro Arg Gly Gly Asp Thr Leu Arg Tyr Asp 1285 1290 1295 Ile Lys Ile Asn Asn Tyr Ala Arg Asn Gly Asp Thr Leu Leu Phe Phe 1300 1305 1310 Phe Ser Tyr Glu Cys Phe Val Gly Asp Lys Met Ile Leu Lys Met Asp 1315 1320 1325 Gly Gly Cys Ala Gly Phe Phe Thr Asp Glu Glu Leu Ala Asp Gly Lys 1330 1335 1340 Gly Val Ile Arg Thr Glu Glu Glu Ile Lys Ala Arg Ser Leu Val Gln 1345 1350 1355 1360 Lys Gln Arg Phe Asn Pro Leu Leu Asp Cys Pro Lys Thr Gln Phe Ser 1365 1370 1375 Tyr Gly Asp Ile His Lys Leu Leu Thr Ala Asp Ile Glu Gly Cys Phe 1380 1385 1390 Gly Pro Ser His Ser Gly Val His Gln Pro Ser Leu Cys Phe Ala Ser 1395 1400 1405 Glu Lys Phe Leu Met Ile Glu Gln Val Ser Lys Val Asp Arg Thr Gly 1410 1415 1420 Gly Thr Trp Gly Leu Gly Leu Ile Glu Gly His Lys Gln Leu Glu Ala 1425 1430 1435 1440 Asp His Trp Tyr Phe Pro Cys His Phe Lys Gly Asp Gln Val Met Ala 1445 1450 1455 Gly Ser Leu Met Ala Glu Gly Cys Gly Gln Leu Leu Gln Phe Tyr Met 1460 1465 1470 Leu His Leu Gly Met His Thr Gln Thr Lys Asn Gly Arg Phe Gln Pro 1475 1480 1485 Leu Glu Asn Ala Ser Gln Gln Val Arg Cys Arg Gly Gln Val Leu Pro 1490 1495 1500 Gln Ser Gly Val Leu Thr Tyr Arg Met Glu Val Thr Glu Ile Gly Phe 1505 1510 1515 1520 Ser Pro Arg Pro Tyr Ala Lys Ala Asn Ile Asp Ile Leu Leu Asn Gly 1525 1530 1535 Lys Ala Val Val Asp Phe Gln Asn Leu Gly Val Met Ile Lys Glu Glu 1540 1545 1550 Asp Glu Cys Thr Arg Tyr Pro Leu Leu Thr Glu Ser Thr Thr Ala Ser 1555 1560 1565 Thr Ala Gln Val Asn Ala Gln Thr Ser Ala Lys Lys Val Tyr Lys Pro 1570 1575 1580 Ala Ser Val Asn Ala Pro Leu Met Ala Gln Ile Pro Asp Leu Thr Lys 1585 1590 1595 1600 Glu Pro Asn Lys Gly Val Ile Pro Ile Ser His Val Glu Ala Pro Ile 1605 1610 1615 Thr Pro Asp Tyr Pro Asn Arg Val Pro Asp Thr Val Pro Phe Thr Pro 1620 1625 1630 Tyr His Met Phe Glu Phe Ala Thr Gly Asn Ile Glu Asn Cys Phe Gly 1635 1640 1645 Pro Glu Phe Ser Ile Tyr Arg Gly Met Ile Pro Pro Arg Thr Pro Cys 1650 1655 1660 Gly Asp Leu Gln Val Thr Thr Arg Val Ile Glu Val Asn Gly Lys Arg 1665 1670 1675 1680 Gly Asp Phe Lys Lys Pro Ser Ser Cys Ile Ala Glu Tyr Glu Val Pro 1685 1690 1695 Ala Asp Ala Trp Tyr Phe Asp Lys Asn Ser His Gly Ala Val Met Pro 1700 1705 1710 Tyr Ser Ile Leu Met Glu Ile Ser Leu Gln Pro Asn Gly Phe Ile Ser 1715 1720 1725 Gly Tyr Met Gly Thr Thr Leu Gly Phe Pro Gly Leu Glu Leu Phe Phe 1730 1735 1740 Arg Asn Leu Asp Gly Ser Gly Glu Leu Leu Arg Glu Val Asp Leu Arg 1745 1750 1755 1760 Gly Lys Thr Ile Arg Asn Asp Ser Arg Leu Leu Ser Thr Val Met Ala 1765 1770 1775 Gly Thr Asn Ile Ile Gln Ser Phe Ser Phe Glu Leu Ser Thr Asp Gly 1780 1785 1790 Glu Pro Phe Tyr Arg Gly Thr Ala Val Phe Gly Tyr Phe Lys Gly Asp 1795 1800 1805 Ala Leu Lys Asp Gln Leu Gly Leu Asp Asn Gly Lys Val Thr Gln Pro 1810 1815 1820 Trp His Val Ala Asn Gly Val Ala Ala Ser Thr Lys Val Asn Leu Leu 1825 1830 1835 1840 Asp Lys Ser Cys Arg His Phe Asn Ala Pro Ala Asn Gln Pro His Tyr 1845 1850 1855 Arg Leu Ala Gly Gly Gln Leu Asn Phe Ile Asp Ser Val Glu Ile Val 1860 1865 1870 Asp Asn Gly Gly Thr Glu Gly Leu Gly Tyr Leu Tyr Ala Glu Arg Thr 1875 1880 1885 Ile Asp Pro Ser Asp Trp Phe Phe Gln Phe His Phe His Gln Asp Pro 1890 1895 1900 Val Met Pro Gly Ser Leu Gly Val Glu Ala Ile Ile Glu Thr Met Gln 1905 1910 1915 1920 Ala Tyr Ala Ile Ser Lys Asp Leu Gly Ala Asp Phe Lys Asn Pro Lys 1925 1930 1935 Phe Gly Gln Ile Leu Ser Asn Ile Lys Trp Lys Tyr Arg Gly Gln Ile 1940 1945 1950 Asn Pro Leu Asn Lys Gln Met Ser Met Asp Val Ser Ile Thr Ser Ile 1955 1960 1965 Lys Asp Glu Asp Gly Lys Lys Val Ile Thr Gly Asn Ala Ser Leu Ser 1970 1975 1980 Lys Asp Gly Leu Arg Ile Tyr Glu Val Phe Asp Ile Ala Ile Ser Ile 1985 1990 1995 2000 Glu Glu Ser Val
【００６５】配列番号： １６ 配列の長さ：１６２９ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AAT CCT ACA GCA ACT AAC GAA ATG CTT TCT CCG TGG CCA TGG GCT 48 Met Asn Pro Thr Ala Thr Asn Glu Met Leu Ser Pro Trp Pro Trp Ala 1 5 10 15 GTG ACA GAG TCA AAT ATC AGT TTT GAC GTG CAA GTG ATG GAA CAA CAA 96 Val Thr Glu Ser Asn Ile Ser Phe Asp Val Gln Val Met Glu Gln Gln 20 25 30 CTT AAA GAT TTT AGC CGG GCA TGT TAC GTG GTC AAT CAT GCC GAC CAC 144 Leu Lys Asp Phe Ser Arg Ala Cys Tyr Val Val Asn His Ala Asp His 35 40 45 GGC TTT GGT ATT GCG CAA ACT GCC GAT ATC GTG ACT GAA CAA GCG GCA 192 Gly Phe Gly Ile Ala Gln Thr Ala Asp Ile Val Thr Glu Gln Ala Ala 50 55 60 AAC AGC ACA GAT TTA CCT GTT AGT GCT TTT ACT CCT GCA TTA GGT ACC 240 Asn Ser Thr Asp Leu Pro Val Ser Ala Phe Thr Pro Ala Leu Gly Thr 65 70 75 80 GAA AGC CTA GGC GAC AAT AAT TTC CGC CGC GTT CAC GGC GTT AAA TAC 288 Glu Ser Leu Gly Asp Asn Asn Phe Arg Arg Val His Gly Val Lys Tyr 85 90 95 GCT TAT TAC GCA GGC GCT ATG GCA AAC GGT ATT TCA TCT GAA GAG CTA 336 Ala Tyr Tyr Ala Gly Ala Met Ala Asn Gly Ile Ser Ser Glu Glu Leu 100 105 110 GTG ATT GCC CTA GGT CAA GCT GGC ATT TTG TGT GGT TCG TTT GGA GCA 384 Val Ile Ala Leu Gly Gln Ala Gly Ile Leu Cys Gly Ser Phe Gly Ala 115 120 125 GCC GGT CTT ATT CCA AGT CGC GTT GAA GCG GCA ATT AAC CGT ATT CAA 432 Ala Gly Leu Ile Pro Ser Arg Val Glu Ala Ala Ile Asn Arg Ile Gln 130 135 140 GCA GCG CTG CCA AAT GGC CCT TAT ATG TTT AAC CTT ATC CAT AGT CCT 480 Ala Ala Leu Pro Asn Gly Pro Tyr Met Phe Asn Leu Ile His Ser Pro 145 150 155 160 AGC GAG CCA GCA TTA GAG CGT GGC AGC GTA GAG CTA TTT TTA AAG CAT 528 Ser Glu Pro Ala Leu Glu Arg Gly Ser Val Glu Leu Phe Leu Lys His 165 170 175 AAG GTA CGC ACC GTT GAA GCA TCA GCT TTC TTA GGT CTA ACA CCA CAA 576 Lys Val Arg Thr Val Glu Ala Ser Ala Phe Leu Gly Leu Thr Pro Gln 180 185 190 ATC GTC TAT TAC CGT GCA GCA GGA TTG AGC CGA GAC GCA CAA GGT AAA 624 Ile Val Tyr Tyr Arg Ala Ala Gly Leu Ser Arg Asp Ala Gln Gly Lys 195 200 205 GTT GTG GTT GGT AAC AAG GTT ATC GCT AAA GTA AGT CGC ACC GAA GTG 672 Val Val Val Gly Asn Lys Val Ile Ala Lys Val Ser Arg Thr Glu Val 210 215 220 GCT GAA AAG TTT ATG ATG CCA GCG CCC GCA AAA ATG CTA CAA AAA CTA 720 Ala Glu Lys Phe Met Met Pro Ala Pro Ala Lys Met Leu Gln Lys Leu 225 230 235 240 GTT GAT GAC GGT TCA ATT ACC GCT GAG CAA ATG GAG CTG GCG CAA CTT 768 Val Asp Asp Gly Ser Ile Thr Ala Glu Gln Met Glu Leu Ala Gln Leu 245 250 255 GTA CCT ATG GCT GAC GAC ATC ACT GCA GAG GCC GAT TCA GGT GGC CAT 816 Val Pro Met Ala Asp Asp Ile Thr Ala Glu Ala Asp Ser Gly Gly His 260 265 270 ACT GAT AAC CGT CCA TTA GTA ACA TTG CTG CCA ACC ATT TTA GCG CTG 864 Thr Asp Asn Arg Pro Leu Val Thr Leu Leu Pro Thr Ile Leu Ala Leu 275 280 285 AAA GAA GAA ATT CAA GCT AAA TAC CAA TAC GAC ACT CCT ATT CGT GTC 912 Lys Glu Glu Ile Gln Ala Lys Tyr Gln Tyr Asp Thr Pro Ile Arg Val 290 295 300 GGT TGT GGT GGC GGT GTG GGT ACG CCT GAT GCA GCG CTG GCA ACG TTT 960 Gly Cys Gly Gly Gly Val Gly Thr Pro Asp Ala Ala Leu Ala Thr Phe 305 310 315 320 AAC ATG GGC GCG GCG TAT ATT GTT ACC GGC TCT ATC AAC CAA GCT TGT 1008 Asn Met Gly Ala Ala Tyr Ile Val Thr Gly Ser Ile Asn Gln Ala Cys 325 330 335 GTT GAA GCG GGC GCA AGT GAT CAC ACT CGT AAA TTA CTT GCC ACC ACT 1056 Val Glu Ala Gly Ala Ser Asp His Thr Arg Lys Leu Leu Ala Thr Thr 340 345 350 GAA ATG GCC GAT GTG ACT ATG GCA CCA GCT GCA GAT ATG TTC GAG ATG 1104 Glu Met Ala Asp Val Thr Met Ala Pro Ala Ala Asp Met Phe Glu Met 355 360 365 GGC GTA AAA CTG CAG GTG GTT AAG CGC GGC ACG CTA TTC CCA ATG CGC 1152 Gly Val Lys Leu Gln Val Val Lys Arg Gly Thr Leu Phe Pro Met Arg 370 375 380 GCT AAC AAG CTA TAT GAG ATC TAC ACC CGT TAC GAT TCA ATC GAA GCG 1200 Ala Asn Lys Leu Tyr Glu Ile Tyr Thr Arg Tyr Asp Ser Ile Glu Ala 385 390 395 400 ATC CCA TTA GAC GAG CGT GAA AAG CTT GAG AAA CAA GTA TTC CGC TCA 1248 Ile Pro Leu Asp Glu Arg Glu Lys Leu Glu Lys Gln Val Phe Arg Ser 405 410 415 AGC CTA GAT GAA ATA TGG GCA GGT ACA GTG GCG CAC TTT AAC GAG CGC 1296 Ser Leu Asp Glu Ile Trp Ala Gly Thr Val Ala His Phe Asn Glu Arg 420 425 430 GAC CCT AAG CAA ATC GAA CGC GCA GAG GGT AAC CCT AAG CGT AAA ATG 1344 Asp Pro Lys Gln Ile Glu Arg Ala Glu Gly Asn Pro Lys Arg Lys Met 435 440 445 GCA TTG ATT TTC CGT TGG TAC TTA GGT CTT TCT AGT CGC TGG TCA AAC 1392 Ala Leu Ile Phe Arg Trp Tyr Leu Gly Leu Ser Ser Arg Trp Ser Asn 450 455 460 TCA GGC GAA GTG GGT CGT GAA ATG GAT TAT CAA ATT TGG GCT GGC CCT 1440 Ser Gly Glu Val Gly Arg Glu Met Asp Tyr Gln Ile Trp Ala Gly Pro 465 470 475 480 GCT CTC GGT GCA TTT AAC CAA TGG GCA AAA GGC AGT TAC TTA GAT AAC 1488 Ala Leu Gly Ala Phe Asn Gln Trp Ala Lys Gly Ser Tyr Leu Asp Asn 485 490 495 TAT CAA GAC CGA AAT GCC GTC GAT TTG GCA AAG CAC TTA ATG TAC GGC 1536 Tyr Gln Asp Arg Asn Ala Val Asp Leu Ala Lys His Leu Met Tyr Gly 500 505 510 GCG GCT TAC TTA AAT CGT ATT AAC TCG CTA ACG GCT CAA GGC GTT AAA 1584 Ala Ala Tyr Leu Asn Arg Ile Asn Ser Leu Thr Ala Gln Gly Val Lys 515 520 525 GTG CCA GCA CAG TTA CTT CGC TGG AAG CCA AAC CAA AGA ATG GCC 1629 Val Pro Ala Gln Leu Leu Arg Trp Lys Pro Asn Gln Arg Met Ala 530 535 540
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 ATG AAT CCT ACA GCA ACT AAC GAA ATG CTT TCT CCG TGG CCA TGG GCT 48 Met Asn Pro Thr Ala Thr Asn Glu Met Leu Ser Pro Trp Pro Trp Ala 1 5 10 15 GTG ACA GAG TCA AAT ATC AGT TTT GAC GTG CAA GTG ATG GAA CAA CAA 96 Val Thr Glu Ser Asn Ile Ser Phe Asp Val Gln Val Met Glu Gln Gln 20 25 30 CTT AAA GAT TTT AGC CGG GCA TGT TAC GTG GTC AAT CAT GCC GAC CAC 144 Leu Lys Asp Phe Ser Arg Ala Cys Tyr Val Val Asn His Ala Asp His 35 40 45 GGC TTT GGT ATT GCG CAA ACT GCC GAT ATC GTG ACT GAA CAA GCG GCA 192 Gly Phe Gly Ile Ala Gln Thr Ala Asp Ile Val Thr Glu Gln Ala Ala 50 55 60 AAC AGC ACA GAT TTA CCT GTT AGT GCT TTT ACT CCT GCA TTA GGT ACC 240 Asn Ser Thr Asp Leu Pro Val Ser Ala Phe Thr Pro Ala Leu Gly Thr 65 70 75 80 GAA AGC CTA GGC GAC AAT AAT TTC CGC CGC GTT CAC GGC GTT AAA TAC 288 Glu Ser Leu Gly Asp Asn Asn Phe Arg Arg Val His Gly Val Lys Tyr 85 90 95 GCT TAT TAC GCA GGC GCT ATG GCA AAC GGT ATT TCA TCT GAA GAG CTA 336 Ala Tyr Tyr Ala Gly Ala Met Ala Asn Gly Ile Ser Ser Glu Glu Leu 100 105 110 GTG ATT GCC CTA GGT CAA GCT GGC ATT TTG TGT GGT TCG TTT GGA GCA 384 Val Ile Ala Leu Gly Gln Ala Gly Ile Leu Cys Gly Ser Phe Gly Ala 115 120 125 GCC GGT CTT ATT CCA AGT CGC GTT GAA GCG GCA ATT AAC CGT ATT CAA 432 Ala Gly Leu Ile Pro Ser Arg Val Glu Ala Ala Ile Asn Arg Ile Gln 130 135 140 GCA GCG CTG CCA AAT GGC CCT TAT ATG TTT AAC CTT ATC CAT AGT CCT 480 Ala Ala Leu Pro Asn Gly Pro Tyr Met Phe Asn Leu Ile His Ser Pro 145 150 155 160 AGC GAG CCA GCA TTA GAG CGT GGC AGC GTA GAG CTA TTT TTA AAG CAT 528 Ser Glu Pro Ala Leu Glu Arg Gly Ser Val Glu Leu Phe Leu Lys His 165 170 175 AAG GTA CGC ACC GTT GAA GCA TCA GCT TTC TTA GGT CTA ACA CCA CAA 576 Lys Val Arg Thr Val Glu Ala Ser Ala Phe Leu Gly Leu Thr Pro Gln 180 185 190 ATC GTC TAT TAC CGT GCA GCA GGA TTG AGC CGA GAC GCA CAA GGT AAA 624 Ile Val Tyr Tyr Arg Ala Ala Gly Leu Ser Arg Asp Ala Gln Gly Lys 195 200 205 GTT GTG GTT GGT AAC AAG GTT ATC GCT AAA GTA AGT CGC ACC GAA GTG 672 Val Val Val Gly Asn Lys Val Ile Ala Lys Val Ser Arg Thr Glu Val 210 215 220 GCT GAA AAG TTT ATG ATG CCA GCG CCC GCA AAA ATG CTA CAA AAA CTA 720 Ala Glu Lys Phe Met Met Pro Ala Pro Ala Lys Met Leu Gln Lys Leu 225 230 235 240 GTT GAT GAC GGT TCA ATT ACC GCT GAG CAA ATG GAG CTG GCG CAA CTT 768 Val Asp Asp Gly Ser Ile Thr Ala Glu Gln Met Glu Leu Ala Gln Leu 245 250 255 GTA CCT ATG GCT GAC GAC ATC ACT GCA GAG GCC GAT TCA GGT GGC CAT 816 Val Pro Met Ala Asp Asp Ile Thr Ala Glu Ala Asp Ser Gly Gly His 260 265 270 ACT GAT AAC CGT CCA TTA GTA ACA TTG CTG CCA ACC ATT TTA GCG CTG 864 Thr Asp Asn Arg Pro Leu Val Thr Leu Leu Pro Thr Ile Leu Ala Leu 275 280 285 AAA GAA GAA ATT CAA GCT AAA TAC CAA TAC GAC ACT CCT ATT CGT GTC 912 Lys Glu Glu Ile Gln Ala Lys Tyr Gln Tyr Asp Thr Pro Ile Arg Val 290 295 300 GGT TGT GGT GGC GGT GTG GGT ACG CCT GAT GCA GCG CTG GCA ACG TTT 960 Gly Cys Gly Gly Gly Val Gly Thr Pro Asp Ala Ala Leu Ala Thr Phe 305 310 315 320 AAC ATG GGC GCG GCG TAT ATT GTT ACC GGC TCT ATC AAC CAA GCT TGT 1008 Asn Met Gly Ala Ala Tyr Ile Val Thr Gly Ser Ile Asn Gln Ala Cys 325 330 335 GTT GAA GCG GGC GCA AGT GAT CAC ACT CGT AAA TTA CTT GCC ACC ACT 1056 Val Glu Ala Gly Ala Ser Asp His Thr Arg Lys Leu Leu Ala Thr Thr 340 345 350 GAA ATG GCC GAT GTG ACT ATG GCA CCA GCT GCA GAT ATG TTC GAG ATG 1104 Glu Met Ala Asp Val Thr Met Ala Pro Ala Ala Asp Met Phe Glu Met 355 360 365 GGC GTA AAA CTG CAG GTG GTT AAG CGC GGC ACG CTA TTC CCA ATG CGC 1152 Gly Val Lys Leu Gln Val Val Lys Arg Gly Thr Leu Phe Pro Met Arg 370 375 380 GCT AAC AAG CTA TAT GAG ATC TAC ACC CGT TAC GAT TCA ATC GAA GCG 1200 Ala Asn Lys Leu Tyr Glu Ile Tyr Thr Arg Tyr Asp Ser Ile Glu Ala 385 390 395 400 ATC CCA TTA GAC GAG CGT GAA AAG CTT GAG AAA CAA GTA TTC CGC TCA 1248 Ile Pro Leu Asp Glu Arg Glu Lys Leu Glu Lys Gln Val Phe Arg Ser 405 410 415 AGC CTA GAT GAA ATA TGG GCA GGT ACA GTG GCG CAC TTT AAC GAG CGC 1296 Ser Leu Asp Glu Ile Trp Ala Gly Thr Val Ala His Phe Asn Glu Arg 420 425 430 GAC CCT AAG CAA ATC GAA CGC GCA GAG GGT AAC CCT AAG CGT AAA ATG 1344 Asp Pro Lys Gln Ile Glu Arg Ala Glu Gly Asn Pro Lys Arg Lys Met 435 440 445 GCA TTG ATT TTC CGT TGG TAC TTA GGT CTT TCT AGT CGC TGG TCA AAC 1392 Ala Leu Ile Phe Arg Trp Tyr Leu Gly Leu Ser Ser Arg Trp Ser Asn 450 455 460 TCA GGC GAA GTG GGT CGT GAA ATG GAT TAT CAA ATT TGG GCT GGC CCT 1440 Ser Gly Glu Val Gly Arg Glu Met Asp Tyr Gln Ile Trp Ala Gly Pro 465 470 475 480 GCT CTC GGT GCA TTT AAC CAA TGG GCA AAA GGC AGT TAC TTA GAT AAC 1488 Ala Leu Gly Ala Phe Asn Gln Trp Ala Lys Gly Ser Tyr Leu Asp Asn 485 490 495 TAT CAA GAC CGA AAT GCC GTC GAT TTG GCA AAG CAC TTA ATG TAC GGC 1536 Tyr Gln Asp Arg Asn Ala Val Asp Leu Ala Lys His Leu Met Tyr Gly 500 505 510 GCG GCT TAC TTA AAT CGT ATT AAC TCG CTA ACG GCT CAA GGC GTT AAA 1584 Ala Ala Tyr Leu Asn Arg Ile Asn Ser Leu Thr Ala Gln Gly Val Lys 515 520 525 GTG CCA GCA CAG TTA CTT CGC TGG AAG CCA AAC CAA AGA ATG GCC 1629 Val Pro Ala Gln Leu Leu Arg Trp Lys Pro Asn Gln Arg Met Ala 530 535 540
【００６６】配列番号： １７ 配列の長さ：５４３ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Met Asn Pro Thr Ala Thr Asn Glu Met Leu Ser Pro Trp Pro Trp Ala 1 5 10 15 Val Thr Glu Ser Asn Ile Ser Phe Asp Val Gln Val Met Glu Gln Gln 20 25 30 Leu Lys Asp Phe Ser Arg Ala Cys Tyr Val Val Asn His Ala Asp His 35 40 45 Gly Phe Gly Ile Ala Gln Thr Ala Asp Ile Val Thr Glu Gln Ala Ala 50 55 60 Asn Ser Thr Asp Leu Pro Val Ser Ala Phe Thr Pro Ala Leu Gly Thr 65 70 75 80 Glu Ser Leu Gly Asp Asn Asn Phe Arg Arg Val His Gly Val Lys Tyr 85 90 95 Ala Tyr Tyr Ala Gly Ala Met Ala Asn Gly Ile Ser Ser Glu Glu Leu 100 105 110 Val Ile Ala Leu Gly Gln Ala Gly Ile Leu Cys Gly Ser Phe Gly Ala 115 120 125 Ala Gly Leu Ile Pro Ser Arg Val Glu Ala Ala Ile Asn Arg Ile Gln 130 135 140 Ala Ala Leu Pro Asn Gly Pro Tyr Met Phe Asn Leu Ile His Ser Pro 145 150 155 160 Ser Glu Pro Ala Leu Glu Arg Gly Ser Val Glu Leu Phe Leu Lys His 165 170 175 Lys Val Arg Thr Val Glu Ala Ser Ala Phe Leu Gly Leu Thr Pro Gln 180 185 190 Ile Val Tyr Tyr Arg Ala Ala Gly Leu Ser Arg Asp Ala Gln Gly Lys 195 200 205 Val Val Val Gly Asn Lys Val Ile Ala Lys Val Ser Arg Thr Glu Val 210 215 220 Ala Glu Lys Phe Met Met Pro Ala Pro Ala Lys Met Leu Gln Lys Leu 225 230 235 240 Val Asp Asp Gly Ser Ile Thr Ala Glu Gln Met Glu Leu Ala Gln Leu 245 250 255 Val Pro Met Ala Asp Asp Ile Thr Ala Glu Ala Asp Ser Gly Gly His 260 265 270 Thr Asp Asn Arg Pro Leu Val Thr Leu Leu Pro Thr Ile Leu Ala Leu 275 280 285 Lys Glu Glu Ile Gln Ala Lys Tyr Gln Tyr Asp Thr Pro Ile Arg Val 290 295 300 Gly Cys Gly Gly Gly Val Gly Thr Pro Asp Ala Ala Leu Ala Thr Phe 305 310 315 320 Asn Met Gly Ala Ala Tyr Ile Val Thr Gly Ser Ile Asn Gln Ala Cys 325 330 335 Val Glu Ala Gly Ala Ser Asp His Thr Arg Lys Leu Leu Ala Thr Thr 340 345 350 Glu Met Ala Asp Val Thr Met Ala Pro Ala Ala Asp Met Phe Glu Met 355 360 365 Gly Val Lys Leu Gln Val Val Lys Arg Gly Thr Leu Phe Pro Met Arg 370 375 380 Ala Asn Lys Leu Tyr Glu Ile Tyr Thr Arg Tyr Asp Ser Ile Glu Ala 385 390 395 400 Ile Pro Leu Asp Glu Arg Glu Lys Leu Glu Lys Gln Val Phe Arg Ser 405 410 415 Ser Leu Asp Glu Ile Trp Ala Gly Thr Val Ala His Phe Asn Glu Arg 420 425 430 Asp Pro Lys Gln Ile Glu Arg Ala Glu Gly Asn Pro Lys Arg Lys Met 435 440 445 Ala Leu Ile Phe Arg Trp Tyr Leu Gly Leu Ser Ser Arg Trp Ser Asn 450 455 460 Ser Gly Glu Val Gly Arg Glu Met Asp Tyr Gln Ile Trp Ala Gly Pro 465 470 475 480 Ala Leu Gly Ala Phe Asn Gln Trp Ala Lys Gly Ser Tyr Leu Asp Asn 485 490 495 Tyr Gln Asp Arg Asn Ala Val Asp Leu Ala Lys His Leu Met Tyr Gly 500 505 510 Ala Ala Tyr Leu Asn Arg Ile Asn Ser Leu Thr Ala Gln Gly Val Lys 515 520 525 Val Pro Ala Gln Leu Leu Arg Trp Lys Pro Asn Gln Arg Met Ala 530 535 540
【００６７】配列番号： １８ 配列の長さ：１５７５ 配列の型： 核酸 鎖の数： 二本鎖 トポロジー：直鎖状 配列の種類：Ｇｅｎｏｍｉｃ ＤＮＡ 起源： シーワネラ・ピュートリファシエンス Ｓ
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GTG CAA CTA CCA TTA ATT GAG GCC TCA TTA GTT AAA TTA TCT GAG CAA 48 Val Gln Leu Pro Leu Ile Glu Ala Ser Leu Val Lys Leu Ser Glu Gln 1 5 10 15 GAG CTC ACC TCT TTA AAT TAC GCT TTT CAG CAA ATG AGA AAG CCA CTA 96 Glu Leu Thr Ser Leu Asn Tyr Ala Phe Gln Gln Met Arg Lys Pro Leu 20 25 30 CAA ACC ATT AAT TAC GAC TAT GCG GTG TGG GAC AGA ACC TAC AGC TAT 144 Gln Thr Ile Asn Tyr Asp Tyr Ala Val Trp Asp Arg Thr Tyr Ser Tyr 35 40 45 ATG AAA TCA AAC TCA GCG AGC GCT AAA AGG TAC TAT GAA AAA CAT GAG 192 Met Lys Ser Asn Ser Ala Ser Ala Lys Arg Tyr Tyr Glu Lys His Glu 50 55 60 TAC CCA GAT GAT ACG TTC AAG AGT TTA AAA GTC GAC GGA GTA TTT ATA 240 Tyr Pro Asp Asp Thr Phe Lys Ser Leu Lys Val Asp Gly Val Phe Ile 65 70 75 80 TTC AAC CGT ACA AAT CAG CCA GTT TTT AGT AAA GGT TTT AAT CAT AGA 288 Phe Asn Arg Thr Asn Gln Pro Val Phe Ser Lys Gly Phe Asn His Arg 85 90 95 AAT GAT ATA CCG CTG GTC TTT GAA TTA ACT GAC TTT AAA CAA CAT CCA 336 Asn Asp Ile Pro Leu Val Phe Glu Leu Thr Asp Phe Lys Gln His Pro 100 105 110 CAA AAC ATC GCA TTA TCT CCA CAA ACC AAA CAG GCA CAC CCA CCG GCA 384 Gln Asn Ile Ala Leu Ser Pro Gln Thr Lys Gln Ala His Pro Pro Ala 115 120 125 AGT AAG CCG TTA GAC TCC CCT GAT GAT GTG CCT TCT ACC CAT GGG GTT 432 Ser Lys Pro Leu Asp Ser Pro Asp Asp Val Pro Ser Thr His Gly Val 130 135 140 ATC GCC ACA CGA TAC GGT CCA GCA ATT TAT AGC TCT ACC AGC ATT TTA 480 Ile Ala Thr Arg Tyr Gly Pro Ala Ile Tyr Ser Ser Thr Ser Ile Leu 145 150 155 160 AAA TCT GAT CGT AGC GGC TCC CAA CTT GGT TAT TTA GTC TTC ATT AGG 528 Lys Ser Asp Arg Ser Gly Ser Gln Leu Gly Tyr Leu Val Phe Ile Arg 165 170 175 TTA ATT GAT GAA TGG TTC ATC GCT GAG CTA TCG CAA TAC ACT GCC GCA 576 Leu Ile Asp Glu Trp Phe Ile Ala Glu Leu Ser Gln Tyr Thr Ala Ala 180 185 190 GGT GTT GAA ATC GCT ATG GCT GAT GCC GCA GAC GCA CAA TTA GCG AGA 624 Gly Val Glu Ile Ala Met Ala Asp Ala Ala Asp Ala Gln Leu Ala Arg 195 200 205 TTA GGC GCA AAC ACT AAG CTT AAT AAA GTA ACC GCT ACA TCC GAA CGG 672 Leu Gly Ala Asn Thr Lys Leu Asn Lys Val Thr Ala Thr Ser Glu Arg 210 215 220 TTA ATA ACT AAT GTC GAT GGT AAG CCT CTG TTG AAG TTA GTG CTT TAC 720 Leu Ile Thr Asn Val Asp Gly Lys Pro Leu Leu Lys Leu Val Leu Tyr 225 230 235 240 CAT ACC AAT AAC CAA CCG CCG CCG ATG CTA GAT TAC AGT ATA ATA ATT 768 His Thr Asn Asn Gln Pro Pro Pro Met Leu Asp Tyr Ser Ile Ile Ile 245 250 255 CTA TTA GTT GAG ATG TCA TTT TTA CTG ATC CTC GCT TAT TTC CTT TAC 816 Leu Leu Val Glu Met Ser Phe Leu Leu Ile Leu Ala Tyr Phe Leu Tyr 260 265 270 TCC TAC TTC TTA GTC AGG CCA GTT AGA AAG CTG GCT TCA GAT ATT AAA 864 Ser Tyr Phe Leu Val Arg Pro Val Arg Lys Leu Ala Ser Asp Ile Lys 275 280 285 AAA ATG GAT AAA AGT CGT GAA ATT AAA AAG CTA AGG TAT CAC TAC CCT 912 Lys Met Asp Lys Ser Arg Glu Ile Lys Lys Leu Arg Tyr His Tyr Pro 290 295 300 ATT ACT GAG CTA GTC AAA GTT GCG ACT CAC TTC AAC GCC CTA ATG GGG 960 Ile Thr Glu Leu Val Lys Val Ala Thr His Phe Asn Ala Leu Met Gly 305 310 315 320 ACG ATT CAG GAA CAA ACT AAA CAG CTT AAT GAA CAA GTT TTT ATT GAT 1008 Thr Ile Gln Glu Gln Thr Lys Gln Leu Asn Glu Gln Val Phe Ile Asp 325 330 335 AAA TTA ACC AAT ATT CCC AAT CGT CGC GCT TTT GAG CAG CGA CTT GAA 1056 Lys Leu Thr Asn Ile Pro Asn Arg Arg Ala Phe Glu Gln Arg Leu Glu 340 345 350 ACC TAT TGC CAA CTG CTA GCC CGG CAA CAA ATT GGC TTT ACT CTC ATC 1104 Thr Tyr Cys Gln Leu Leu Ala Arg Gln Gln Ile Gly Phe Thr Leu Ile 355 360 365 ATT GCC GAT GTG GAT CAT TTT AAA GAG TAC AAC GAT ACT CTT GGG CAC 1152 Ile Ala Asp Val Asp His Phe Lys Glu Tyr Asn Asp Thr Leu Gly His 370 375 380 CTT GCT GGG GAT GAA GCA TTA ATA AAA GTG GCA CAA ACA CTA TCG CAA 1200 Leu Ala Gly Asp Glu Ala Leu Ile Lys Val Ala Gln Thr Leu Ser Gln 385 390 395 400 CAG TTT TAC CGT GCA GAA GAT ATT TGT GCC CGT TTT GGT GGT GAA GAA 1248 Gln Phe Tyr Arg Ala Glu Asp Ile Cys Ala Arg Phe Gly Gly Glu Glu 405 410 415 TTT ATT ATG TTA TTT CGA GAC ATA CCT GAT GAG CCC TTG CAG AGA AAG 1296 Phe Ile Met Leu Phe Arg Asp Ile Pro Asp Glu Pro Leu Gln Arg Lys 420 425 430 CTC GAT GCG ATG CTG CAC TCT TTT GCA GAG CTC AAC CTA CCT CAT CCA 1344 Leu Asp Ala Met Leu His Ser Phe Ala Glu Leu Asn Leu Pro His Pro 435 440 445 AAC TCA TCA ACC GCT AAT TAC GTT ACT GTG AGC CTT GGG GTT TGC ACA 1392 Asn Ser Ser Thr Ala Asn Tyr Val Thr Val Ser Leu Gly Val Cys Thr 450 455 460 GTT GTT GCT GTT GAT GAT TTT GAA TTT AAA AGT GAG TCG CAT ATT ATT 1440 Val Val Ala Val Asp Asp Phe Glu Phe Lys Ser Glu Ser His Ile Ile 465 470 475 480 GGC AGT CAG GCT GCA TTA ATC GCA GAT AAG GCG CTT TAT CAT GCT AAA 1488 Gly Ser Gln Ala Ala Leu Ile Ala Asp Lys Ala Leu Tyr His Ala Lys 485 490 495 GCC TGT GGT CGT AAC CAG TTG TCA AAA ACT ACT ATT ACT GTT GAT GAG 1536 Ala Cys Gly Arg Asn Gln Leu Ser Lys Thr Thr Ile Thr Val Asp Glu 500 505 510 ATT GAG CAA TTA GAA GCA AAT AAA ATC GGT CAT CAA GCC 1575 Ile Glu Gln Leu Glu Ala Asn Lys Ile Gly His Gln Ala 515 520 525
ＣＲＣ−２８７４ （ＦＥＲＭ ＢＰ−１６２５） 配列 GTG CAA CTA CCA TTA ATT GAG GCC TCA TTA GTT AAA TTA TCT GAG CAA 48 Val Gln Leu Pro Leu Ile Glu Ala Ser Leu Val Lys Leu Ser Glu Gln 1 5 10 15 GAG CTC ACC TCT TTA AAT TAC GCT TTT CAG CAA ATG AGA AAG CCA CTA 96 Glu Leu Thr Ser Leu Asn Tyr Ala Phe Gln Gln Met Arg Lys Pro Leu 20 25 30 CAA ACC ATT AAT TAC GAC TAT GCG GTG TGG GAC AGA ACC TAC AGC TAT 144 Gln Thr Ile Asn Tyr Asp Tyr Ala Val Trp Asp Arg Thr Tyr Ser Tyr 35 40 45 ATG AAA TCA AAC TCA GCG AGC GCT AAA AGG TAC TAT GAA AAA CAT GAG 192 Met Lys Ser Asn Ser Ala Ser Ala Lys Arg Tyr Tyr Glu Lys His Glu 50 55 60 TAC CCA GAT GAT ACG TTC AAG AGT TTA AAA GTC GAC GGA GTA TTT ATA 240 Tyr Pro Asp Asp Thr Phe Lys Ser Leu Lys Val Asp Gly Val Phe Ile 65 70 75 80 TTC AAC CGT ACA AAT CAG CCA GTT TTT AGT AAA GGT TTT AAT CAT AGA 288 Phe Asn Arg Thr Asn Gln Pro Val Phe Ser Lys Gly Phe Asn His Arg 85 90 95 AAT GAT ATA CCG CTG GTC TTT GAA TTA ACT GAC TTT AAA CAA CAT CCA 336 Asn Asp Ile Pro Leu Val Phe Glu Leu Thr Asp Phe Lys Gln His Pro 100 105 110 CAA AAC ATC GCA TTA TCT CCA CAA ACC AAA CAG GCA CAC CCA CCG GCA 384 Gln Asn Ile Ala Leu Ser Pro Gln Thr Lys Gln Ala His Pro Pro Ala 115 120 125 AGT AAG CCG TTA GAC TCC CCT GAT GAT GTG CCT TCT ACC CAT GGG GTT 432 Ser Lys Pro Leu Asp Ser Pro Asp Asp Val Pro Ser Thr His Gly Val 130 135 140 ATC GCC ACA CGA TAC GGT CCA GCA ATT TAT AGC TCT ACC AGC ATT TTA 480 Ile Ala Thr Arg Tyr Gly Pro Ala Ile Tyr Ser Ser Thr Ser Ile Leu 145 150 155 160 AAA TCT GAT CGT AGC GGC TCC CAA CTT GGT TAT TTA GTC TTC ATT AGG 528 Lys Ser Asp Arg Ser Gly Ser Gln Leu Gly Tyr Leu Val Phe Ile Arg 165 170 175 TTA ATT GAT GAA TGG TTC ATC GCT GAG CTA TCG CAA TAC ACT GCC GCA 576 Leu Ile Asp Glu Trp Phe Ile Ala Glu Leu Ser Gln Tyr Thr Ala Ala 180 185 190 GGT GTT GAA ATC GCT ATG GCT GAT GCC GCA GAC GCA CAA TTA GCG AGA 624 Gly Val Glu Ile Ala Met Ala Asp Ala Ala Asp Ala Gln Leu Ala Arg 195 200 205 TTA GGC GCA AAC ACT AAG CTT AAT AAA GTA ACC GCT ACA TCC GAA CGG 672 Leu Gly Ala Asn Thr Lys Leu Asn Lys Val Thr Ala Thr Ser Glu Arg 210 215 220 TTA ATA ACT AAT GTC GAT GGT AAG CCT CTG TTG AAG TTA GTG CTT TAC 720 Leu Ile Thr Asn Val Asp Gly Lys Pro Leu Leu Lys Leu Val Leu Tyr 225 230 235 240 CAT ACC AAT AAC CAA CCG CCG CCG ATG CTA GAT TAC AGT ATA ATA ATT 768 His Thr Asn Asn Gln Pro Pro Pro Met Leu Asp Tyr Ser Ile Ile Ile 245 250 255 CTA TTA GTT GAG ATG TCA TTT TTA CTG ATC CTC GCT TAT TTC CTT TAC 816 Leu Leu Val Glu Met Ser Phe Leu Leu Ile Leu Ala Tyr Phe Leu Tyr 260 265 270 TCC TAC TTC TTA GTC AGG CCA GTT AGA AAG CTG GCT TCA GAT ATT AAA 864 Ser Tyr Phe Leu Val Arg Pro Val Arg Lys Leu Ala Ser Asp Ile Lys 275 280 285 AAA ATG GAT AAA AGT CGT GAA ATT AAA AAG CTA AGG TAT CAC TAC CCT 912 Lys Met Asp Lys Ser Arg Glu Ile Lys Lys Leu Arg Tyr His Tyr Pro 290 295 300 ATT ACT GAG CTA GTC AAA GTT GCG ACT CAC TTC AAC GCC CTA ATG GGG 960 Ile Thr Glu Leu Val Lys Val Ala Thr His Phe Asn Ala Leu Met Gly 305 310 315 320 ACG ATT CAG GAA CAA ACT AAA CAG CTT AAT GAA CAA GTT TTT ATT GAT 1008 Thr Ile Gln Glu Gln Thr Lys Gln Leu Asn Glu Gln Val Phe Ile Asp 325 330 335 AAA TTA ACC AAT ATT CCC AAT CGT CGC GCT TTT GAG CAG CGA CTT GAA 1056 Lys Leu Thr Asn Ile Pro Asn Arg Arg Ala Phe Glu Gln Arg Leu Glu 340 345 350 ACC TAT TGC CAA CTG CTA GCC CGG CAA CAA ATT GGC TTT ACT CTC ATC 1104 Thr Tyr Cys Gln Leu Leu Ala Arg Gln Gln Ile Gly Phe Thr Leu Ile 355 360 365 ATT GCC GAT GTG GAT CAT TTT AAA GAG TAC AAC GAT ACT CTT GGG CAC 1152 Ile Ala Asp Val Asp His Phe Lys Glu Tyr Asn Asp Thr Leu Gly His 370 375 380 CTT GCT GGG GAT GAA GCA TTA ATA AAA GTG GCA CAA ACA CTA TCG CAA 1200 Leu Ala Gly Asp Glu Ala Leu Ile Lys Val Ala Gln Thr Leu Ser Gln 385 390 395 400 CAG TTT TAC CGT GCA GAA GAT ATT TGT GCC CGT TTT GGT GGT GAA GAA 1248 Gln Phe Tyr Arg Ala Glu Asp Ile Cys Ala Arg Phe Gly Gly Glu Glu 405 410 415 TTT ATT ATG TTA TTT CGA GAC ATA CCT GAT GAG CCC TTG CAG AGA AAG 1296 Phe Ile Met Leu Phe Arg Asp Ile Pro Asp Glu Pro Leu Gln Arg Lys 420 425 430 CTC GAT GCG ATG CTG CAC TCT TTT GCA GAG CTC AAC CTA CCT CAT CCA 1344 Leu Asp Ala Met Leu His Ser Phe Ala Glu Leu Asn Leu Pro His Pro 435 440 445 AAC TCA TCA ACC GCT AAT TAC GTT ACT GTG AGC CTT GGG GTT TGC ACA 1392 Asn Ser Ser Thr Ala Asn Tyr Val Thr Val Ser Leu Gly Val Cys Thr 450 455 460 GTT GTT GCT GTT GAT GAT TTT GAA TTT AAA AGT GAG TCG CAT ATT ATT 1440 Val Val Ala Val Asp Asp Phe Glu Phe Lys Ser Glu Ser His Ile Ile 465 470 475 480 GGC AGT CAG GCT GCA TTA ATC GCA GAT AAG GCG CTT TAT CAT GCT AAA 1488 Gly Ser Gln Ala Ala Leu Ile Ala Asp Lys Ala Leu Tyr His Ala Lys 485 490 495 GCC TGT GGT CGT AAC CAG TTG TCA AAA ACT ACT ATT ACT GTT GAT GAG 1536 Ala Cys Gly Arg Asn Gln Leu Ser Lys Thr Thr Ile Thr Val Asp Glu 500 505 510 ATT GAG CAA TTA GAA GCA AAT AAA ATC GGT CAT CAA GCC 1575 Ile Glu Gln Leu Glu Ala Asn Lys Ile Gly His Gln Ala 515 520 525
【００６８】配列番号： １９ 配列の長さ：５２５ 配列の型： アミノ酸 配列の種類：ペプチド 配列 Val Gln Leu Pro Leu Ile Glu Ala Ser Leu Val Lys Leu Ser Glu Gln 1 5 10 15 Glu Leu Thr Ser Leu Asn Tyr Ala Phe Gln Gln Met Arg Lys Pro Leu 20 25 30 Gln Thr Ile Asn Tyr Asp Tyr Ala Val Trp Asp Arg Thr Tyr Ser Tyr 35 40 45 Met Lys Ser Asn Ser Ala Ser Ala Lys Arg Tyr Tyr Glu Lys His Glu 50 55 60 Tyr Pro Asp Asp Thr Phe Lys Ser Leu Lys Val Asp Gly Val Phe Ile 65 70 75 80 Phe Asn Arg Thr Asn Gln Pro Val Phe Ser Lys Gly Phe Asn His Arg 85 90 95 Asn Asp Ile Pro Leu Val Phe Glu Leu Thr Asp Phe Lys Gln His Pro 100 105 110 Gln Asn Ile Ala Leu Ser Pro Gln Thr Lys Gln Ala His Pro Pro Ala 115 120 125 Ser Lys Pro Leu Asp Ser Pro Asp Asp Val Pro Ser Thr His Gly Val 130 135 140 Ile Ala Thr Arg Tyr Gly Pro Ala Ile Tyr Ser Ser Thr Ser Ile Leu 145 150 155 160 Lys Ser Asp Arg Ser Gly Ser Gln Leu Gly Tyr Leu Val Phe Ile Arg 165 170 175 Leu Ile Asp Glu Trp Phe Ile Ala Glu Leu Ser Gln Tyr Thr Ala Ala 180 185 190 Gly Val Glu Ile Ala Met Ala Asp Ala Ala Asp Ala Gln Leu Ala Arg 195 200 205 Leu Gly Ala Asn Thr Lys Leu Asn Lys Val Thr Ala Thr Ser Glu Arg 210 215 220 Leu Ile Thr Asn Val Asp Gly Lys Pro Leu Leu Lys Leu Val Leu Tyr 225 230 235 240 His Thr Asn Asn Gln Pro Pro Pro Met Leu Asp Tyr Ser Ile Ile Ile 245 250 255 Leu Leu Val Glu Met Ser Phe Leu Leu Ile Leu Ala Tyr Phe Leu Tyr 260 265 270 Ser Tyr Phe Leu Val Arg Pro Val Arg Lys Leu Ala Ser Asp Ile Lys 275 280 285 Lys Met Asp Lys Ser Arg Glu Ile Lys Lys Leu Arg Tyr His Tyr Pro 290 295 300 Ile Thr Glu Leu Val Lys Val Ala Thr His Phe Asn Ala Leu Met Gly 305 310 315 320 Thr Ile Gln Glu Gln Thr Lys Gln Leu Asn Glu Gln Val Phe Ile Asp 325 330 335 Lys Leu Thr Asn Ile Pro Asn Arg Arg Ala Phe Glu Gln Arg Leu Glu 340 345 350 Thr Tyr Cys Gln Leu Leu Ala Arg Gln Gln Ile Gly Phe Thr Leu Ile 355 360 365 Ile Ala Asp Val Asp His Phe Lys Glu Tyr Asn Asp Thr Leu Gly His 370 375 380 Leu Ala Gly Asp Glu Ala Leu Ile Lys Val Ala Gln Thr Leu Ser Gln 385 390 395 400 Gln Phe Tyr Arg Ala Glu Asp Ile Cys Ala Arg Phe Gly Gly Glu Glu 405 410 415 Phe Ile Met Leu Phe Arg Asp Ile Pro Asp Glu Pro Leu Gln Arg Lys 420 425 430 Leu Asp Ala Met Leu His Ser Phe Ala Glu Leu Asn Leu Pro His Pro 435 440 445 Asn Ser Ser Thr Ala Asn Tyr Val Thr Val Ser Leu Gly Val Cys Thr 450 455 460 Val Val Ala Val Asp Asp Phe Glu Phe Lys Ser Glu Ser His Ile Ile 465 470 475 480 Gly Ser Gln Ala Ala Leu Ile Ala Asp Lys Ala Leu Tyr His Ala Lys 485 490 495 Ala Cys Gly Arg Asn Gln Leu Ser Lys Thr Thr Ile Thr Val Asp Glu 500 505 510 Ile Glu Gln Leu Glu Ala Asn Lys Ile Gly His Gln Ala 515 520 525
【００６９】
【図１】図１は本発明の遺伝子群を含むプラスミドｐＥ
ＰＡの構造を示す。
ＰＡの構造を示す。
【図２】図２は本発明の遺伝子群を含むＤＮＡ断片の制
限酵素地図を示す。
限酵素地図を示す。
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 // Ａ６１Ｋ 31/20 ＡＣＢ Ａ６１Ｋ 31/20 ＡＣＢ (Ｃ１２Ｎ 1/21 Ｃ１２Ｒ 1:19） (Ｃ１２Ｎ 9/00 Ｃ１２Ｒ 1:19） (Ｃ１２Ｐ 7/64 Ｃ１２Ｒ 1:19）
Claims (16)
- 【請求項１】 配列番号：１で示される塩基配列によっ
てコード化されたイコサペンタエン酸生合成酵素群をコ
ードする遺伝子。 - 【請求項２】 配列番号：１の５６６１〜３４６３１に
表された塩基配列によってコード化されたイコサペンタ
エン酸生合成酵素群をコードする遺伝子。 - 【請求項３】 配列番号：１の７７１０〜３５５６４に
表された塩基配列によってコード化されたイコサペンタ
エン酸生合成酵素群をコードする遺伝子。 - 【請求項４】 配列番号：１の７７１０〜３４６３１に
表された塩基配列によってコード化されたイコサペンタ
エン酸生合成酵素群をコードする遺伝子。 - 【請求項５】 配列番号：７及び９で示されるアミノ酸
配列を少なくとも含んで成るイコサペンタエン酸生合成
酵素群をコードする遺伝子。 - 【請求項６】 配列番号：６及び８で示される塩基配列
を少なくとも含んで成るイコサペンタエン酸生合成酵素
群をコードする遺伝子。 - 【請求項７】 配列番号：５、１１、１３、１５、１７
及び１９で示されるアミノ酸配列群から選ばれた少なく
とも一つのアミノ酸配列を含んで成るイコサペンタエン
酸生合成酵素群をコードする遺伝子。 - 【請求項８】 配列番号：４、１０、１２、１４、１６
及び１８で示される塩基配列群から選ばれた少なくとも
一つの塩基配列を含んで成るイコサペンタエン酸生合成
酵素群をコードする遺伝子。 - 【請求項９】 配列番号：１３及び１５で示されるアミ
ノ酸配列から成る群より選ばれた一つのアミノ酸配列を
表すイコサペンタエン酸生合成に関する酵素をコードす
る遺伝子。 - 【請求項１０】 配列番号：１２及び１４で示される塩
基配列から成る群より選ばれた一つの塩基配列を表すイ
コサペンタエン酸生合成に関する酵素をコードする遺伝
子。 - 【請求項１１】 請求項１、２、３、４、５、６、７、
８、９、１０のいずれかに記載の遺伝子を含んで成るプ
ラスミド。 - 【請求項１２】 請求項１に記載の遺伝子を含んで成る
プラスミドにより形質転換された細菌。 - 【請求項１３】 請求項２、３、４のいずれかに記載の
遺伝子を含んで成るプラスミドにより形質転換された細
菌。 - 【請求項１４】 請求項１２に記載の細菌を培養する工
程を含んで成るイコサペンタエン酸の生産方法。 - 【請求項１５】 請求項１３に記載の細菌を培養する工
程を含んで成るイコサペンタエン酸の生産方法。 - 【請求項１６】 次の工程により得られるイコサペンタ
エン酸生合成酵素群をコードする遺伝子。 イコサペンタエン酸を生産する能力があるシーワネラ
(Shewanella)属に属する微生物を培養し細胞を得る。 培養した細胞より染色体ＤＮＡを抽出する。 制限酵素Ｓａｕ３Ａ１により染色体ＤＮＡを部分消化
し、ＤＮＡ断片を得る。 制限酵素ＢａｍＨ１により完全消化したコスミドｐＷ
Ｅ１５にＤＮＡ断片を挿入し、組み換え体発現ベクター
を得る。 組み換え体発現ベクターにより大腸菌を形質転換し、
形質転換菌を得る。 形質転換菌を培養し、形質転換菌細胞を得る。 形質転換した細胞よりイコサペンタエン酸を検出し、
イコサペンタエン酸を生産する能力がある形質転換菌を
選択する。そして、 イコサペンタエン酸を生産する能力がある形質転換菌
より抽出した組み換え体発現ベクターを制限酵素Ｓａｕ
３Ａ１により切断することにより、イコサペンタエン酸
生合成酵素群をコードするＤＮＡを回収する。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8003485A JPH08242867A (ja) | 1995-01-13 | 1996-01-12 | イコサペンタエン酸生合成酵素群をコードする遺伝子及びイコサペンタエン酸の製造法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP429995 | 1995-01-13 | ||
| JP7-4299 | 1995-01-13 | ||
| JP8003485A JPH08242867A (ja) | 1995-01-13 | 1996-01-12 | イコサペンタエン酸生合成酵素群をコードする遺伝子及びイコサペンタエン酸の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH08242867A true JPH08242867A (ja) | 1996-09-24 |
Family
ID=26337071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8003485A Pending JPH08242867A (ja) | 1995-01-13 | 1996-01-12 | イコサペンタエン酸生合成酵素群をコードする遺伝子及びイコサペンタエン酸の製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH08242867A (ja) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001565A1 (fr) * | 1996-07-10 | 1998-01-15 | Sagami Chemical Research Center | Procede de production d'acide icosapentaenoique par recombinaison genetique |
| JP2007037415A (ja) * | 2005-08-01 | 2007-02-15 | Hokkaido Univ | 細胞の脂肪酸組成を改変する方法およびその利用 |
-
1996
- 1996-01-12 JP JP8003485A patent/JPH08242867A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001565A1 (fr) * | 1996-07-10 | 1998-01-15 | Sagami Chemical Research Center | Procede de production d'acide icosapentaenoique par recombinaison genetique |
| JP2007037415A (ja) * | 2005-08-01 | 2007-02-15 | Hokkaido Univ | 細胞の脂肪酸組成を改変する方法およびその利用 |
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