JPH08231378A - Bathing agent composition - Google Patents

Abstract

PURPOSE: To obtain a bathing agent composition having high ameliorating effect for various symptoms involved in skin pruritus or eczema without staining bathing water and bathtub, also safe to the skin, by formulating an extract obtained from seeds of Avena sativa Linne using a specific solvent. CONSTITUTION: This bathing agent composition contains, as active ingredient, an extract obtained by extracting seeds of (Avena sativa Linne) with water and/or a water-soluble organic solvent (pref. at least one kind selected from ethanol, butanol, propylene glycol and 1,3-butylene glycol). The extract is pref. the aqueous fraction obtained by fractionation with water plus ethyl acetate. Besides, this composition contains pref. an inorganic salt (e.g. sodium sulfate, sodium carbonate), carbon dioxide or a carbon dioxide-generating material. It is preferable that the amount of the extract to be formulated in this composition be such a level, per 150-200L of bathing water, as to be obtained from 0.001-1000g of raw seed powder of Avena sativa Linne.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath agent composition which does not stain bath water and bathtub and can safely improve itching and eczema of the skin.

[0002]

BACKGROUND OF THE INVENTION Bath salts are generally Glauber's salt, borax, sulfur,
Inorganic salt mixtures such as carbonates and oily components (for example, JP-A-2-
No. 115117) and the like containing a fragrance, a coloring agent, a plant extract, an organic acid, etc., to keep the skin clean, give a scent and color to the bath water, improve fatigue recovery, metabolism, enhance a warm feeling, It enhances the skin care effect. In recent years, plant extracts such as fermented rice extract, garlic extract and jojoba oil have been used for the purpose of improving the skin care effect against various skin conditions associated with eczema, atopic dermatitis, dry dermatitis and the like.

Of these, plant extracts such as rice fermented extract, garlic extract, jojoba oil and the like are currently poorly recognized by clinical and consumers, but oats ( Avena)
sativa Linne) seed powder, especially in the United States,
Since ancient times, it has been marketed as a medicine as an active ingredient of bath salts for the purpose of treating skin inflammation, diseases, and itching caused by trauma, and has received great support from clinical and consumers. As a typical product, colloidal oatmeal blended with AVEENO (trademark: S.C. Johnson) is known.

However, bath water using oat seed powder has an effect on skin irritations, illnesses, and itchiness caused by trauma, but it contains a large amount of insoluble components in the bath water, and thus bubbles, dirt, and turbidity. However, precipitates were generated, and its application was not generally widespread.

In order to solve this problem, a product has been developed in which powder of oats seeds is efficiently dispersed in the bath water to suppress bubbles, turbidity, and precipitates in the bath water due to insoluble components as much as possible. 261116), the effect was recognized by many US consumers, and the utilization of oat seed powder has been increased.

[0006] However, the problems of foaming, stains, turbidity, and precipitates of bath water due to insoluble components still remain, and the present situation is that a fundamental solution has not been reached.

[0007]

SUMMARY OF THE INVENTION It is, therefore, an object of the present invention to provide a bath water and a bath salt which does not stain the bath while maintaining the effect of oat seeds.

[0008]

Means for Solving the Problems In view of such circumstances, the present inventor has conducted diligent research, and as a result, if a mixture of oat seeds extracted with a specific solvent is blended, the bath water and the bath will be contaminated. The present invention has been completed by finding that a bath salt having a high effect of improving various symptoms associated with itching and eczema of the skin and having a safe skin is obtained.

That is, the present invention relates to oats ( Avena sa
tiva Linne) seeds, and a bath salt composition containing an extract extracted with water or / and a water-soluble organic solvent.

As described above, it is already known that oat seeds are used as a powder in a bath salt, but these extracts are mainly used as cosmetics in Europe and North America to Used as a skin care agent (Fragrance Journal Extra Edition No. 6 (1
986) only. That is, it is used as an external preparation applied to the skin in the form of a cosmetic, and there is no example of a form used as a bath agent. The reason for this is that the effectiveness of oats in the bathing system has not yet been scientifically clarified, and the existence of the active ingredient itself has not been clarified.

The oats extract of the present invention is obtained by extracting from oats ( Avena sativa Linne) seeds. Extraction from oat seeds
In order to efficiently obtain the active ingredient, it is necessary to use water and / or a water-soluble organic solvent. Examples of the water-soluble organic solvent used here include methanol, ethanol, propanol, butanol, propylene glycol, and 1,3-butylene glycol. Among them, ethanol, butanol, propylene glycol,
1,3-butylene glycol is preferred. The water-soluble organic solvent may be used alone or in combination of two or more, and it is preferable to combine it with water. The amount of the solvent to the oats is preferably 1 to 20 times by weight.

On the other hand, the oats used as a raw material are preferably coarse powder or powder rather than being used for extraction as it is. Although oats may be immersed in the above extraction solvent and extracted by a conventional method, the extraction efficiency may be increased by heating to about 50 ° C. if necessary. Further, if the extract as it is or after being concentrated is fractionated with a solvent and only the effective fraction is taken out, a higher effect can be expected with a smaller amount. The solvent used for fractionation here is preferably water and ethyl acetate, and it is preferable to use this water fraction.

The extract thus obtained may be concentrated if necessary and further powdered with an excipient. Any excipient may be used as long as it ensures stability, but generally, a polysaccharide such as dextrin or an inorganic powder such as calcium silicate is used.

The amount of the extract obtained as described above in the bath agent composition is not particularly limited, but it is 0.0 to 100 l of standard bath water and the bulk powder of oat seeds is 0.0.
The amount of the extract obtained from 01 to 1000 g is preferable, and the amount of the extract obtained from 0.01 to 100 g of bulk powder is more preferable. This amount is 0.001g
If it is less, sufficient effects may not be obtained, and even if more than 100 g is blended, it will be wasteful and cloudiness or coloring of the bath water may occur. Occurrence and coloring are likely to occur.

The bathing agent composition of the present invention is effective even if only the above extract is blended, but the effect of the present invention can be further enhanced by further blending an inorganic salt, carbon dioxide gas or a carbon dioxide gas generator. it can.

Examples of such inorganic salts include sulfates, carbonates, and chlorides, and specific examples include Glauber's salt, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, and salt. These inorganic salts are contained in the composition in an amount of 5 to 98% by weight (hereinafter referred to simply as "%"), particularly 20 to 95%.
It is preferable to mix them.

Further, the carbon dioxide gas generating product may be a product comprising a carbonate and an acid. Here, as the carbonate,
Examples of the above compounds include fumaric acid, succinic acid, adipic acid, malic acid, tartaric acid, citric acid, pyrrolidonecarboxylic acid, and acid salts of these organic acids. Carbonate is 5-80%, especially 10-60%, acid is 1
It is preferable to add 0 to 80%, especially 15 to 60%. Further, when a bathing agent that generates carbon dioxide is added to the bathing water, the ratio is such that the bathing water exhibits a weak acidity, that is, a 0.01 wt% aqueous solution (40 ° C) of the bathing agent has a pH of 4 to 7, particularly pH.
It is preferable to set it to be 6.0 to 6.7.

The bath additive composition of the present invention may further contain known raw materials for bath agents described below which are generally used in bath agents. The raw materials for bath agents which can be blended are exemplified below. It is not limited to one.

(A) Herbal medicines, herbal medicines, herbal medicine Sojutsu, juniper, valerian, mussel, koboku, senkyu, spruce, touki, jasmine, ginger, carrot, keihi, peony, mint,
Scutellaria, Sanshishi, Bukuro, Dokukatsu, Shobu, Guyou, Matsuba, Juniper, Jouyaku, Camphor, Saffron, Oataku, Fennel, Chinpi, Can peel, Chamomile, Peach leaf, Rosemary, Melissa, Marronier, Arnica, Sage, etc.

(A) Essential oils, fragrances Mint oil, jasmine oil, camphor oil, cypress oil, spruce oil, ryu oil, mandarin oil, orange oil, yuzu oil, shovel oil, lavender oil, bay oil, clove oil, hiba Oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, sage oil, bergamot oil, iris oil, pine oil, menthol, dl-menthol, l-menthol, cineole, eugenol, citral, citronellol, citronellal, borneol , Linalool, geraniol, phenylethyl alcohol, benzyl acetate,
Camphor, thymol, spilanthol, pinene, terpene compounds, etc.

(C) Fats and oils Nuca oil, rice bran extract, olive oil, soybean oil, jojoba oil, avocado oil, almond oil, sesame oil, coconut oil, sunflower oil, castor oil, cacao oil, mink oil, beef tallow, lard,
Natural fats and oils such as fish fat, evening primrose oil and rose hip oil, and hydrogenated oils and glyceride derivatives obtained by hydrogenating these. Waxes such as carnauba wax, beeswax and lanolin. Hydrocarbons such as liquid paraffin, paraffin, petrolatum and squalane. Higher aliphatic compounds such as lauric acid, myristic acid, palmitic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid.
Lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, 2-
Higher alcohols such as exyldecanol and ester derivatives thereof.

(D) Silicones

(E) Dyes Blue No. 1, Blue No. 2, Yellow No. 4, Yellow No. 5, Green No. 3,
Tar dyes such as Green No. 4, Green No. 204, and Yellow No. 202 (1) specified by the Ordinance of the Ministry of Health and Welfare, food additives such as chlorophyll, riboflavin, crocin, anthraquinone, cotinyl, canthaxanthin, safflower Natural pigments recognized as products

(F) Vitamin vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, etc.

(G) Polyhydric alcohols Glycerin, butylene glycol, propylene glycol, sorbitol, dextrose, mannitol, etc.

(H) Fine powder Generally referred to as cosmetic powder, which includes acrylic resin, styrene resin, epoxy resin, silicone resin, nylon,
Polyethylene, polypropylene, polyvinyl chloride, PE
Polymers such as T and polytetrafluoroethane, copolymers of these polymer compounds, calcium silicate, natural aluminum silicate, synthetic aluminum silicate, zeolite, titanium oxide, talc, kaolin, mica, bentonite,
Silicic anhydride, calcium carbonate, etc.

(X) Water-soluble polymer PEG, CMC, PVP, gelatin, agar, gum arabic, guar gum, etc.

(Co) Surfactant As the surfactant, any of anionic, cationic, nonionic, natural and synthetic surfactants can be used.

(Sa) Others Yunohana, sulfur, casein, bran, mica powder, dextrin, skim milk powder, urea, amino acids and the like can be added. Furthermore, the bath salt composition of the present invention may include, in addition to those described above, a bactericidal preservative (eg, benzoic acid ester, sorbic acid, etc.), a sequestering agent (eg, EDT), if necessary.
A, NTA, etc.), other compounding agents such as proteolytic enzymes can be added.

The bath preparation composition of the present invention contains an extract from oats seeds as an essential component, and the above optional components are uniformly stirred and mixed in a mixer according to a conventional method, and if necessary, powder or granules. , A tablet, a liquid, an emulsified state and the like, and the form thereof may be a bath salt type, a bubble bath type, an effervescent type, etc., and the manufacturing method can be appropriately selected. Regarding the pH (40 ° C., 0.01%) when the bath agent composition of the present invention is dissolved, it does not adversely affect the ordinary bath and its accessories, and is about 4 to 10 Although not particularly limited, it is preferable to keep the pH of the bath water at 4 to 7 when the effect of carbon dioxide gas is particularly expected.

[0031]

EFFECTS OF THE INVENTION The bath agent composition of the present invention exhibits excellent skin care effects in a smaller amount without polluting the bath water or bathtub, as compared with oat seed powder itself, and is associated with itching and eczema of the skin. Excellent in improving symptoms.

[0032]

The present invention will be described below with reference to examples and test examples, but the present invention is not limited to these examples.

Example 1 Extract from oat seeds (1) 2 kg of 1,3-butylene glycol: purified water (1 volume: 1 volume) mixed solution was added to 1 kg of crude oat seeds, and the mixture was stirred at 50 ° C. for 10 hours. Extract. After the solid matter was filtered, the filtrate was allowed to stand at 5 ° C. for several days, and precipitated precipitates were removed by filtration to obtain 0.98 kg of a slightly yellowish clear extract. Although the recovery rate of the extract was about 50%, 1 g of the extract in this example was obtained from the ratio of the amount of oat seeds charged and the amount of the extraction solvent.
Corresponds to about 0.5 g of oats seeds.

Example 2 Extract from oat seeds (2) 1 kg of crude oat seeds was diluted with ethanol: purified water (1
Volume: 1 volume) Add 5 kg of the mixed solution, and extract by stirring at 50 ° C. for 10 hours. After the solid matter is filtered, the filtrate is concentrated under reduced pressure at 60 ° C. or lower until the total amount becomes about 1/10 volume, and ethyl acetate is adjusted to 0.
After adding 5 kg and stirring sufficiently, the mixture is left to stand to obtain a lower layer as a liquid separation. The lower layer was concentrated under reduced pressure to obtain a brown viscous product (oats seeds 1 kg → 0.10 kg). To this, 100 g of pharmacopoeial dextrin and an appropriate amount of purified water were added and dissolved, and a trace amount of insoluble matter was filtered with a filter paper, and then spray-dried to obtain 200 g of a dried matter. 1 g of this product corresponds to 5 g of oats seeds.

Examples 3 and 4 Fractionation of extract from oat seeds 1 kg crude oat seeds ethanol: purified water (1
Volume: 1 volume) Add 5 kg of the mixed solution, and extract by stirring at 50 ° C. for 10 hours. After the solid matter is filtered, the filtrate is concentrated under reduced pressure at 60 ° C. or lower until the total amount becomes about 1/10 volume, and ethyl acetate is adjusted to 0.
After adding 5 kg and stirring sufficiently, the mixture is allowed to stand, and liquid separation is performed to obtain a lower layer portion. The lower layer was concentrated under reduced pressure to obtain a brown viscous product (oats seeds 1 kg → 0.10 kg). Take 100 g of the extract from this oat seed and add 1 kg of water.
1 kg of ethyl acetate was added, and the mixture was fractionated by a separating funnel according to a conventional method. To the extract distributed in water, 1 kg of butanol was added and fractionated with a separating funnel to concentrate water, butanol, and soluble matter. Water-soluble fraction: 26 g
(Example 3), butanol-soluble fraction: 40 g (Example 4) of a fraction was obtained. Each 1 g of this fraction corresponds to about 38 g and 25 g of oat seeds, respectively.

Test Example 1 Bath Water Solubility Test Twenty extracts of the extract (1) from oat seeds of Example 1 were used.
g, 4 g of the extract (2) from the oat seeds of Example 2 and 3 g of the extract from the oat seeds of Example 3 (3)
Water fraction (0.26 g), butanol fraction (0.4 g), and oat seed powder (AVEENO (trademark: SCS Johnson)) (Comparative Example 1) (10 g) in bath water (40 ° C., 150 ° C.).
Table 1 shows the results of examining the degree of soiling of the bath water immediately after being poured into 1) and the bath water after draining the bath water after 2 hours. 20 g of the extract (1) from oat seeds of the present invention,
4 g of extract (2) from oat seeds of the invention,
The water fraction (0.26 g) and butanol fraction (0.4 g) of the extract (3) from oat seeds of the present invention correspond to 10 g of oat seed powder.

[0037]

[Table 1]

As is clear from the above results, the extract (1) of Example 1 of the present invention, the extract (2) of Example 2 and the water-soluble fraction of Example 3 of the present invention were used. The butanol-soluble fraction of Example 4 was able to completely prevent stains in the bath water as compared with oat seed powder (AVEENO). In the bath containing the oats seed powder (AVEENO) of Comparative Example 1, since there were many insoluble components, bubbles, dirt, turbidity, precipitates, etc. were observed and a peculiar odor was observed. Also, the bathtub after drainage was extremely dirty, and as a result, it took a considerable amount of time to clean it.

Test Example 2 Evaluation of Drug Efficacy In order to evaluate the drug efficacy of the extract from oats seeds, an ultraviolet erythema test was conducted to evaluate the drug efficacy in the bathing system. In accordance with the usual method, one group of 6 Hartley female guinea pigs weighing about 230 g was shaved on the back skin and exposed to ultraviolet rays (UV).
B) was irradiated with 1.5 MED. Then, 4 g of the extract (1) of Example 1 of the present invention, 4 g of the extract (2) of Example 2, the water-soluble fraction of Example 3, the butanol-soluble fraction of Example 4, and the oats of Comparative Example 1 were used. Seed powder (AVEENO (trademark:
S.C. Johnson) was prepared as bath water (40 ° C.) at the concentration used in Test Example 1, bathed for 30 minutes, and erythema 24 hours after bathing was evaluated according to the criteria in Table 2. The results are shown in Table 3.
Shown in

[0040]

[Table 2]

[0041]

[Table 3]

As is clear from the above results, the extract (1) of Example 1 of the present invention, the extract (2) of Example 2 and the water-soluble fraction of Example 3 of the present invention were used. The butanol-soluble fraction of Example 4 was used as a seed powder of the oats of Comparative Example 1 (AV
Similar to EENO), it was revealed that it has an excellent anti-inflammatory activity against ultraviolet erythema.

From the results of Test Examples 1 and 2, the extract (1) of Example 1 of the present invention, the extract (2) of Example 2, and the water-soluble fraction of Example 3 of the present invention, Example It was revealed that the butanol-soluble fraction of No. 4 had less effect on bath water and bathtub, and showed a medicinal effect in a smaller amount than the seed powder of oats.

Examples 5 to 16 Next, the effects of the present invention will be specifically described with reference to specific formulations containing the extract of oat seeds of the present invention. Tables 4 to 6 below show Examples 5 to 16 and Comparative Examples 2 to 7.
Each bath agent composition was prepared according to the formulation shown in 6.
The reference single-use amount was specified for each.

[0045]

[Table 4]

[0046]

[Table 5]

[0047]

[Table 6]

Test Example 3 Evaluation of drug efficacy Among the above formulation examples, Examples 5, 9, 13 and Comparative Examples 2 to 7
The evaluation of the medicinal effect of is performed by the ultraviolet erythema test of Test Example 2,
The efficacy of the bathing system was evaluated. Each formulation was subjected to an experiment at a concentration in which a reference single-use amount was dissolved in 150 l of bath water. The results are shown in Table 7.

[0049]

[Table 7]

As is clear from the above results, the bath salt preparations of Examples 5, 9, and 13 of the present invention were prepared by adding hot water or Comparative Example 2.
It was shown to have excellent anti-inflammatory activity as compared with ~ 7. Further, it was shown that even when compared with Comparative Example 1, a smaller amount of the extract compound had excellent anti-inflammatory activity.
It can be easily estimated from the results of Test Example 2 that the same effects can be obtained by conducting a drug efficacy test on the preparations of the other Examples.

When the bath preparations of Examples 3 to 16 of the present invention were put into a bath, bubbles caused by an insoluble component,
It was extremely easy to use, with no stains, turbidity, or precipitation.

Claims (5)

[Claims] 1. A bath agent composition containing an extract extracted from oats ( Avena sativa Linne) seeds using water and / or a water-soluble organic solvent. 2. The bath salt composition according to claim 1, wherein the water-soluble organic solvent is one or more selected from ethanol, butanol, propylene glycol and 1,3-butylene glycol. 3. A bath salt containing a water fraction obtained by fractionating oat seeds ( Avena sativa Linne) seeds extracted with water and / or a water-soluble organic solvent with water and ethyl acetate. Composition. 4. The bath agent composition according to claim 1, further comprising an inorganic salt. 5. The bath agent composition according to any one of claims 1 to 4, which further contains carbon dioxide gas or a carbon dioxide gas product.