JPH08196632A - Syringe - Google Patents

Abstract

PURPOSE: To easily perform filling and sterilization of injection solution and secure safety against pollution, etc., by forming an operation hole in the wall face of an outer cylinder and rotating a plug body by operation form the operation hole so as to make a filling chamber of the injection solution communicate with an injection port. CONSTITUTION: A syringe 1 comprises an outer cylinder which has an injection port 2A for attaching an injection needle in its tip part and a plunger 3 which has a tip end attached to a gasket 4 so as to be fitted in the outer cylinder 2. The plug body 5 is arranged in the tip inner part of the outer cylinder 2 so as to plug the injection port 2A, and injection solution is densely filled between the plug body 5 and the gasket 4. An operation hole is formed in a part of a wall face of the outer cylinder 2 being in contact with the plug body 5 and the plug body 5 is rotated by operation from the operation hole so as to make a filling chamber 6 of the injection solution communicate with the injection outlet 2A. And in the case of injection, the plug body 5 is rotated by holding a projection part 5A at first. A recessed part 10 of the plug body 5 is thus detached from the projection part 9 of the outer cylinder 2 so that the filling chamber 6 and the injection outlet 2a are made to communicated with each other.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe pre-filled with an injection agent, and more specifically, to fill the outer tube with the injection agent in a liquid-tight manner to facilitate sterilization. It relates to a syringe that can be used.

[0002]

2. Description of the Related Art Recently, in order to prevent medical accidents and to prevent hospital infections as much as possible, a pre-filled syringe containing a drug or a drug solution has been pre-sterilized in a sterile condition. A syringe, commonly referred to as a field syringe, has been proposed. In addition, a multi-component injector has also been proposed in which such a pre-field syringe is filled with two or more medicinal components of injections separately until the time of injection.

Conventionally, in such an injector, in addition to an outer cylinder having an injection port to which an injection needle is attached at a tip and a plunger having a gasket which is liquid-tightly inserted into the outer cylinder, the injection port is provided. It has been proposed to have a plug body that is inserted in a liquid-tight manner and is placed deep inside the tip of the outer cylinder, and in which the injection liquid is liquid-tightly filled between the plug body and the gasket (actually, Kaihei 2-51560). In such a syringe, the outer cylinder can be liquid-tightly filled with a predetermined amount of the injection liquid almost completely (a state in which air or the like hardly enters the filling chamber).
Further, steam sterilization and the like are also extremely easy, and if the gasket can be slid to some extent during sterilization, a method can be adopted in which smooth sterilization can be carried out without applying pressure to the filling chamber (Japanese Patent Laid-Open No. 253296/1993). Japanese Patent Laid-Open No. 5-305
No. 140).

Filling the injection liquid in a liquid-tight manner without allowing air or the like to enter has an advantage that a doctor or a nurse can directly inject the syringe without deaeration. For example, in the case of heparin injection, when degassed, the outside of the injection needle may get wet with heparin before injection and post-bleeding may occur, but such inconvenience is avoided if direct injection is possible.

[0005]

However, in the conventional syringe, a double-ended needle type injection needle having a needle insertion portion at both ends is used in order to make the injection port and the filling chamber communicate with each other at the time of injection. Since such an injection needle punctures the stopper inside the outer cylinder once when the injection port is attached, there is a risk that the contamination resistance against handling of the injection needle may be lost. In addition, since it is necessary to attach the injection needle at the injection site, the safety against contamination during operation is reduced. Therefore, an object of the present invention is to provide a pre-liquid-filled syringe that can be easily filled and sterilized with an injection, and that can sufficiently secure safety against handling and contamination during injection.

[0006]

The present invention comprises an outer cylinder having an injection port to which an injection needle is attached at the tip, and a plunger having a gasket attached to the tip and inserted into the outer cylinder. Further, in a syringe in which a plug is arranged at the inner part of the tip of the outer cylinder to close the injection port and the injection liquid is liquid-tightly filled between the injection port and the gasket, the outer portion in contact with the plug is An operation hole is formed in a part of the wall surface of the cylinder,
In addition, a part or the whole of the stopper is rotated by an operation from the operation hole to connect the injection liquid filling chamber and the injection port to each other. The above object is achieved by providing the following.

According to the present invention, a convex portion is formed on the inner wall surface of the outer cylinder which is in contact with the plug body, and a concave portion which fits the convex portion is formed on the outer wall surface of the plug body. Is provided so that the convex portion and the concave portion are disengaged from each other to connect the injection liquid filling chamber and the injection port.

According to the present invention, a concave portion or a fitting hole is formed on a wall surface of the outer cylinder which is in contact with the plug body, and a convex portion which is fitted to the concave portion or the fitting hole is formed on the outer wall surface of the plug body. Is formed, and the convex portion and the concave portion or the fitting hole are disengaged from each other by the rotation of the plug body, and the filling chamber for the injection solution and the injection port are communicated with each other.

According to the present invention, further, a communication passage is formed in the stopper to connect the injection liquid filling chamber and the injection port,
Further, a part of the plug body is composed of a movable member which can be rotated from the operation hole, and the communication passage is opened and closed by the rotation of the movable member.

The present invention also provides a multi-component in which at least one partition plug body is movably disposed in the outer cylinder between the plug body and the gasket and is filled with two or more injections. It may be an injection syringe.

[0011]

In the above-mentioned syringe, at the time of manufacturing the syringe, the stopper is first inserted into the outer cylinder, and the stopper is operated through the operation hole so that the injection agent filling chamber and the injection port are in communication with each other. Then, the gasket is inserted into the outer cylinder to a predetermined position, and a filling nozzle or the like is used to fill a predetermined amount of the injection agent from the injection port to almost full fill. After that, an injection needle or the like may be attached to the ejection port in advance. Next, rotate the stopper to close the injection port,
Sterilize injections by autoclaving. In this case, pressure can be prevented from being applied to the filling chamber by making the plunger and the gasket slidable to some extent. Further, in the operation of using the syringe, the injection port and the filling chamber communicate with each other and the injection can be performed only by rotating the stopper through the operation hole when using the syringe. In addition, since the injection needle can be attached to the injection port in advance, there is little contamination, and nosocomial infections are prevented as much as possible, and direct injection is also possible. Therefore, a medical accident, which is the original purpose, can be prevented.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT A preferred embodiment of the syringe according to the present invention will be described below in detail with reference to the accompanying drawings. 1 (a) and 1 (b) are side views of a first embodiment of the syringe of the present invention.
2A and 2B are longitudinal sectional views of the first embodiment of the syringe of the present invention. 3 (a) and 3 (b) are cross-sectional views of essential parts of the first embodiment of the syringe of the present invention.

The syringe 1 of the first embodiment shown in FIGS. 1 to 3.
Consists of an outer cylinder 2 having an injection port 2A at the tip of which an injection needle is attached, and a plunger 3 having a gasket 4 attached at the tip and fitted into the outer cylinder 2.
The plug 5 is arranged in the inner part of the tip end to close the ejection port 2A and the plug 5
The injection liquid is liquid-tightly filled between and the gasket 4.
Further, an operation hole 7 is formed in a part of the wall surface of the outer cylinder 2 which is in contact with the stopper body 5, and the stopper body 5 is rotated by an operation from the operation hole 7 to be filled with the injection liquid filling chamber 6. It communicates with the ejection port 2A.

The syringe of this embodiment will be further described with reference to FIG.
As shown in (a) and (b), a convex portion 9 is formed on the inner wall surface of the outer cylinder 2 which is in contact with the plug body 5, and a concave portion 10 for fitting with the convex portion 9 is formed on the outer wall surface of the plug body 5. When the stopper 5 is rotated, the convex portion 9 and the concave portion 10 are disengaged from each other, and the injection liquid filling chamber 6
The inside is communicated with the ejection port 2.

The outer cylinder 2 of the syringe 1 of this embodiment may be a glass cylinder or a plastic cylinder. However, the outer cylinder 2 is preferably a plastic cylinder because the operation hole 7 and the like are formed in the outer cylinder 2. Examples of the plastic material used include low density or high density polyethylene, polypropylene, polyolefins such as polybutadiene-1, polyvinyl chloride,
Polyvinylidene chloride, vinylidene chloride copolymer, polymethyl methacrylate, polyvinyl alcohol, ethylene-
Examples thereof include vinyl alcohol copolymer, acrylonitrile copolymer, polyethylene terephthalate and the like. In particular, polyolefins are preferable because they are versatile and do not affect the drug. Further, amorphous cyclic olefin copolymers and the like have a high glass transition temperature and a specific gravity of 1.
A light weight of 1 or less is desirable.

The gasket 4 and the plug 5 may be any as long as they have an elastic body that maintains liquid tightness with the inner wall of the outer cylinder 2. Specifically, a rubber gasket and a rubber stopper are used.
A protrusion 5A for operation is provided on the side peripheral surface of the plug body in contact with the inner wall of the outer cylinder.
Is formed, and the protrusion 5A is formed on the outer cylinder 2 when it is mounted in the outer cylinder 2.
It is inserted into the operation hole 7 and is projected to the outside. Further, a concave portion 10 is formed on the side peripheral surface of the plug body on the side substantially opposite to the position where the protruding portion 5A is formed, and the concave portion 10 is adapted to fit with the convex portion 9 formed on the inner wall of the outer cylinder 2. There is. And the recess 1
When the 0 and the convex portion 9 are fitted together, the plug body 5 is liquid-tightly adhered to the inner wall of the outer cylinder 2 to close the injection port 2A, and when the concave portion 10 and the convex portion 9 are disengaged, the plug body 5 A part of the outer wall is separated from the inner wall of the outer cylinder 2 so that the injection can flow out to the injection port 2A.

In manufacturing the syringe 1 according to this embodiment, first, the plug 5 is inserted deep into the outer cylinder 2 and the projection 5A of the plug 5 is inserted into the rectangular operation hole 7 of the outer cylinder. Place it in the inserted state. Next, the protrusion 5A from the operation hole 7 is operated so that the recess 5A of the plug 5 is disengaged from the protrusion 9 of the outer cylinder 2, and the injection port 2A and the inside of the outer cylinder (filling chamber 6) are connected. To communicate with each other.

Next, the gasket 4 is set by pushing it into the outer cylinder 2 to a predetermined position, and a predetermined amount of injection liquid is injected into the filling chamber 6 from the injection port 2A using a filling nozzle or the like. After the injection liquid is completely filled, the protrusion 5A of the stopper 5 is rotated to fit the recess 10 of the stopper 5 and the protrusion 9 of the outer cylinder so that the space between the injection port 2A and the filling chamber 6 is increased. Close. After that, the injection port 2A
An injection needle (not shown) is attached to the syringe 1, and the syringe 1 is sterilized by high-pressure steam to sterilize the injection solution 6 in the filling chamber 6. In this embodiment, the injection needle does not have to be attached to the injection port.

When using the syringe 1 of this embodiment for injection, first, in the state shown in FIG. 2A, the projection 5A of the stopper 5 is gripped and the stopper 5 is rotated. As a result, the concave portion 10 of the plug body 5 is removed from the convex portion 9 of the outer cylinder 2 as shown in FIG. As a result, the filling chamber 6 and the ejection port 2A communicate with each other, and injection is possible. In this case, the injection liquid is filled in the filling chamber 6 in a state where there is almost no air, and direct injection or the like is possible.
Moreover, since a double-ended needle type injection needle is not used for the syringe 1,
An injection needle can be attached to the syringe 1 in advance, and it is possible to reduce contamination accidents at the work site.

In the syringe 1 of this embodiment, the plug 5 is provided with the concave portion 10 and the outer cylinder 2 is provided with the convex portion 9, but the concave portion 10 and the convex portion 9 have the same operation and effect. As long as a concave part or a fitting hole is formed on the wall surface of the outer cylinder and a convex part is formed on the outer wall surface of the plug body, the convex part and the concave part or the fitting hole are disengaged from each other by the rotation of the plug body. The liquid filling chamber may communicate with the injection port.

Next, the syringe of the second embodiment of the present invention will be explained with reference to FIGS. 4 (a) and 4 (b). The syringe 20 has a gasket 4 and a plug 21, and the operation hole 7 is formed in the wall of the outer cylinder 2 in almost the same manner as the syringe 1 of the first embodiment, but differs in the following points. . A part of the plug 21 serves as a rotating member 22, and the other plug members 23 do not rotate. The rotation member 22 and the plug member 23 communicate with the injection liquid filling chamber 6 and the injection port 2A through communication passages 24 and 2.
5 are formed, and the communication passages 24 and 25 are closed as shown in FIG. 4A or opened as shown in FIG. 4B by the rotating operation of the rotating member 22. . The syringe 20 having such a configuration can be manufactured in the same manner as the syringe 1 of the first embodiment, and
Similar effects can be exhibited in the operation during use. Further, by forming the communication passages 24 and 25, a reliable communication operation can be performed.

Next, the injector of the third embodiment of the present invention will be explained with reference to FIGS. 5 (a) and 5 (b). The syringe 30 has a gasket 4 and a plug 21, and the operation hole 7 is formed in the wall of the outer cylinder 2 in almost the same manner as the syringe 20 of the second embodiment, but differs in the following points. . The present embodiment is a multi-component injector 30, in which a partition plug body 31 is movably arranged in the outer cylinder 2 between a plug body 21 and a gasket 4 and filled with two types of injection agents 32 and 33. There is. Further, the outer cylinder 2 is formed of plastic, and the side wall of the outer cylinder 2 located between the partition plug body 31 and the plug body 21 has a long hole 34 penetrating inside and outside.
Is formed. The elongated hole 34 is covered with a cover member 35 mounted on the outer wall of the outer cylinder 2, and the wall thickness of the outer cylinder 2 is a bypass passage width for allowing the injection liquid to flow in the elongated hole 34 as shown in FIG. ing. Further, the length L of the long hole 34 is formed larger than the liquid-tight width region W of the partition plug body 31.

The syringe 30 having such a structure can be manufactured in the same manner as the syringe 20 of the second embodiment, and the same operational effect can be obtained in the operation during use. That is, after inserting the plug 21 into the inner part of the distal end of the outer cylinder 2, the communication passages 24 and 25 of the plug 21 are communicated. Then, the partition plug body 31 is inserted into the outer cylinder 2 to a predetermined position, and then the injection liquid 33 is filled from the base end opening 2B of the outer cylinder 2 and the gasket 4 is fitted to the predetermined position inside the outer cylinder 2. To insert. Next, the injection liquid 32 is filled from the injection port 2A, and the communication passages 24 and 25 of the stopper 21 are closed.

When the plunger 3 is pushed in after the rubber stopper 21 is rotated to form the communication passages 24 and 25, the partition stopper 31 together with the gasket 4 is also pushed in via the injection solution 33. Injection 3 by this pressing
When most of 2 is injected through the communication passages 25 and 24, the partition plug body 31 comes to the position of the bypass passage of the elongated hole 34 (position of FIG. 5B). When the plunger 3 is pushed further in, the second injection liquid 33 causes the bypass passage and the communication passage 2
It passes through 5, 24 and is ejected. Therefore, the two-part injectable solution can be stored without mixing until just before the injection. Incidentally, in the above-mentioned embodiment, two kinds of injection solutions 32 and 33 are used.
In the above, the pre-field is used, but a multi-component injection device in which two or more partition plugs 31 are provided to provide three or more injection solutions may be used.

Next, a syringe according to a fourth embodiment of the present invention will be described with reference to FIGS. 6 (a) and 6 (b). The syringe 40 has the gasket 4, the partition plug body 31, and the plug body 21, and the operation hole 7 and the long hole 34 for the bypass passage are formed in the wall of the outer cylinder 2 in that the syringe 30 of the third embodiment. But is different in the following points. The multi-component injector 40 of the present embodiment is that the injection drug is filled with the powder drug 41 and the solution 42 of the drug in the outer cylinder 2. Also in the syringe 20 having such a configuration, the syringe 30 of the third embodiment
In addition to being manufactured in the same manner as above, the same operation and effect can be exhibited in the operation during use. Further, the dissolution liquid 42 can pass through the bypass passage of the long hole 34 during operation to dissolve the drug 41, and the mixed liquid thereof can be administered as an injection preparation.

[0026]

As described above, the syringe of the present invention is
An operation hole is formed in a part of the wall surface of the outer cylinder which is in contact with the plug body, and the plug body is partially or wholly rotated by an operation from the operation hole, so that the injection solution Since the filling chamber communicates with the injection port, filling and sterilization of the injection can be easily performed, and safety for handling during injection and contamination is sufficiently ensured.

[Brief description of drawings]

1A and 1B are side views of a first embodiment of a syringe according to the present invention.

2 (a) and 2 (b) are vertical cross-sectional views of a first embodiment of the syringe according to the present invention.

3 (a) and 3 (b) are cross-sectional views of essential parts of the first embodiment of the syringe according to the present invention.

4 (a) and 4 (b) are longitudinal sectional views of a second embodiment of the syringe according to the present invention.

5 (a) and 5 (b) are longitudinal sectional views of a third embodiment of the syringe according to the present invention.

6 (a) and 6 (b) are longitudinal sectional views of a fourth embodiment of the syringe according to the present invention.

[Explanation of symbols]

 1,20,30,40 Syringe 2A Outer cylinder 2 Outlet of outer cylinder 3 Plunger 4 Gasket 5,21 Plug 6 Filling chamber 7 Operation hole 9 Convex portion on inner wall of outer cylinder 10 Recess 24 on outer wall of plug 25 Communication Passage 31 Partition Plug 32, 33, 41, 42 Injection 34 Long Hole (Bypass Passage) 35 Cover Member

Claims (5)

[Claims] 1. An outer cylinder having an injection port to which an injection needle is attached at a tip portion, and a plunger having a gasket attached to the tip and inserted into the outer cylinder. In a syringe in which a plug is placed in a portion to close the injection port and the injection liquid is liquid-tightly filled between the injection port and the gasket, a part of the wall surface of the outer cylinder in contact with the plug is operated. A hole is formed, and the plug is partially or wholly rotated by an operation from the operation hole to connect the injection solution filling chamber and the injection port. Pre-filled syringe. 2. A convex portion is formed on an inner wall surface of the outer cylinder which is in contact with the plug body, and a concave portion which fits the convex portion is formed on an outer wall surface of the plug body. The syringe according to claim 1, wherein the convex portion and the concave portion are disengaged from each other by the movement, and the filling chamber for the injection liquid and the ejection port are communicated with each other. 3. A concave portion or a fitting hole is formed on a wall surface of the outer cylinder which is in contact with the plug body, and a convex portion which is fitted to the concave portion or the fitting hole is formed on an outer wall surface of the plug body. The syringe according to claim 1, wherein the convex portion and the concave portion or the fitting hole are disengaged from each other by the rotation of the stopper, and the chamber for filling the injection liquid and the ejection port are communicated with each other. 4. The plug body is formed with a communication passage that connects the injection liquid filling chamber and the injection port, and a part of the plug body is a movable member rotatable from the operation hole. The syringe according to claim 1, wherein the communication passage is opened and closed by the rotation of the movable member. 5. At least one partition plug body is movably disposed in the outer cylinder between the plug body and the gasket, and is filled with two or more kinds of injectable agents. The syringe according to any one of claims 1 to 4.