JPH08196461A - Antibacterial wiper - Google Patents
Antibacterial wiperInfo
- Publication number
- JPH08196461A JPH08196461A JP2739095A JP2739095A JPH08196461A JP H08196461 A JPH08196461 A JP H08196461A JP 2739095 A JP2739095 A JP 2739095A JP 2739095 A JP2739095 A JP 2739095A JP H08196461 A JPH08196461 A JP H08196461A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- silver
- wiper
- collagen
- based inorganic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Body Washing Hand Wipes And Brushes (AREA)
- Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、清拭した個所に優れた
殺菌性あるいは防黴性などの抗菌性を長期間持続するこ
とのできる抗菌性ワイパーに関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antibacterial wiper capable of maintaining antibacterial properties such as excellent bactericidal property and antifungal property for a long period of time on a wiped part.
【０００２】[0002]
【従来の技術】ワイパーとしては、ぬれティシュ、お手
ふき、幼児用おしりふき、介護用おしりふき、衣類のし
みとり、ＯＡ製品用クリーナー等に見られるように身体
や物品の清拭を目的としてつくられた基材に清浄液を含
浸させた製品が知られている。従来、清浄液を含浸する
基材には、不織布、脱脂綿、パルプ紙等のシート状物又
はシート状物を折り畳んだもの、あるいはロール状にし
たものがあり、清浄液には水、アルコール類などを用い
て、これらを基材に含浸させて気密性容器又は気密性シ
ートにより密封して使用時に適宜開封して用いていた。2. Description of the Related Art As a wiper, it is made for the purpose of cleaning the body and articles as seen in wet tissues, wipes, wipes for infants, wipes for care, stain remover for clothes, cleaners for OA products, etc. A product in which a base material is impregnated with a cleaning liquid is known. Background Art Conventionally, a base material impregnated with a cleaning solution includes a sheet-like material such as a non-woven fabric, absorbent cotton, and pulp paper, or a sheet-like material folded or rolled, and the cleaning solution includes water, alcohols, and the like. The base material was impregnated with these, and sealed with an airtight container or an airtight sheet, and then opened appropriately at the time of use.
【０００３】上記従来のワイパーは、基材に含浸する清
浄液の主成分が自体抗菌性のない水溶液であることか
ら、細菌や黴が増殖しやすく、これを防止するため殺菌
剤あるいは防黴剤として、特にパラオキシ安息香酸エス
テル、塩化ベンザルコニウム、グルコン酸クロルヘキシ
ジン、塩化セチルピリジニウム等を用いていた。しか
し、上記殺菌剤あるいは防黴剤は単独では微生物の一時
的な繁殖を防止できるものの、ウェットワイパーとして
用いたときに、有効成分の上記殺菌剤あるいは防黴剤が
基材に吸着したままとなり、清拭面の抗菌活性が弱く、
殺菌性や防黴性が時間経過と共に著しく低下する〔例え
ば日本清浄紙綿類工業会の技術資料No1(平成６年10月)
、「ウェットワイパー類に使用する各薬剤の担体に対
する吸着について」参照〕ので、清拭した後に抗菌性あ
るいは防黴性を長期間持続させることは無理であった。In the above conventional wiper, since the main component of the cleaning liquid impregnated into the base material is an aqueous solution having no antibacterial property itself, bacteria and mold are prone to proliferate, and in order to prevent this, a bactericide or a fungicide. In particular, paraoxybenzoic acid ester, benzalkonium chloride, chlorhexidine gluconate, cetylpyridinium chloride and the like were used. However, although the bactericide or fungicide alone can prevent the temporary growth of microorganisms, when used as a wet wiper, the bactericide or fungicide of the active ingredient remains adsorbed on the substrate, The antibacterial activity of the wiped surface is weak,
The bactericidal and mildew-proof properties are significantly reduced with the passage of time [eg Technical Paper No. 1 of the Japan Clean Paper Cotton Industry Association (October 1994).
, "Adsorption of each drug used in wet wipers to a carrier"], it was impossible to maintain the antibacterial or antifungal properties for a long time after wiping.
【０００４】[0004]
【従来技術の問題点】特に介護用のおしりふきのための
ウェットワイパーは、老人などの病人の身体の拭き取り
と共に床ずれ防止のために緑膿菌に有効な抗菌性をもっ
た薬液、または拭き取った後で臭いの発生を防止するた
めに水棲菌や蛋白質分解酵素に対する抗菌性が乾燥面で
長期に亘って持続するものが求められていた。さらに病
院等の雑菌の多い場所ではドアーノブやベッド回りを清
拭した際に、拭いた後で清拭面に長期に亘って抗菌性が
持続しないとその後の落下菌に対して抵抗力がなくな
り、防菌のための清拭の用を果すことができなかった。[Problems of the prior art] Wet wipers, especially for wipes for nursing care, are used to wipe the body of sick people such as the elderly as well as an antibacterial drug solution effective against Pseudomonas aeruginosa to prevent bedsores, or after wiping Therefore, in order to prevent the generation of odor, it is required that the antibacterial properties against aquatic bacteria and proteolytic enzymes last for a long time in a dry state. Furthermore, when cleaning the door knob and bed area in a place with many germs such as hospitals, if the antibacterial property does not persist for a long time on the cleaned surface after wiping, resistance to subsequent falling bacteria will disappear, I couldn't do the cleaning work to prevent bacteria.
【０００５】従来の殺菌剤あるいは防黴剤として多用さ
れるエチルアルコールは揮発性が高いので一時的な効果
しかなく、これを含浸させたウェットワイパーで拭いた
面は乾燥後は抗菌性を持続させることができなかった。
また、パラオキシ安息香酸エステルを用いたときには皮
膚粘膜をピリピリと刺激する不快感があり、しかも使用
に際してアルコール等に溶解して水に配合されるので、
乾燥状態では抗菌性が著しく低下する。さらに塩化ベン
ザルコニウム、グルコン酸クロルヘキシジンや塩化セチ
ルピリジニウムを用いた場合には、繊維素系の基材に対
して９５重量％程度の吸着性が観察されており、これを
含浸させたワイパーで拭いた後の面には有効成分が殆ど
含まれていないので、拭きとり後には抗菌性は全くとい
う程存在しなかった。アルコールを用いない従来技術と
しては特公平4-53531 号や特開平5-15467 号があるが、
いずれも拭いた後の乾燥面に抗菌性を長期間持続させる
ことは出来なかった。従来の技術では、含浸する中液の
細菌や黴に対する安全対策として清拭時の一時的な抗菌
性のために殺菌剤あるいは防黴剤が用いられているもの
であり、拭くことにより清拭面に長期間に亘って抗菌性
を付与するものではなかった。また拭いた面が乾燥状態
で抗菌性を維持するには、従来の有機系の殺菌剤あるい
は防黴剤では無理であった。Since ethyl alcohol, which is widely used as a conventional bactericide or antifungal agent, has a high volatility, it has only a temporary effect. The surface wiped with a wet wiper impregnated with ethyl alcohol retains its antibacterial property after drying. I couldn't.
Also, when paraoxybenzoic acid ester is used, there is an unpleasant sensation that irritates the skin and mucous membranes, and since it is dissolved in alcohol etc. and mixed in water when used,
In the dry state, the antibacterial property is significantly reduced. Furthermore, when benzalkonium chloride, chlorhexidine gluconate, or cetylpyridinium chloride was used, an adsorbability of about 95% by weight to the fibrous base material was observed, and wiping with a wiper impregnated with this was observed. After the wiping, there was almost no antibacterial property, since the surface after the wiping had almost no active ingredient. As prior arts that do not use alcohol, there are Japanese Patent Publication No. 4-53531 and Japanese Patent Application Laid-Open No. 5-15467.
In all cases, the antibacterial property could not be maintained for a long time on the dry surface after wiping. In the conventional technology, a bactericidal agent or an antifungal agent is used for temporary antibacterial property during wiping as a safety measure against bacteria and mold of the medium liquid to be impregnated. It did not impart antibacterial properties over a long period of time. Further, in order to maintain the antibacterial property in a dry state on the wiped surface, it has been impossible to use a conventional organic bactericide or fungicide.
【０００６】[0006]
【発明が解決しようとする課題】本発明は、拭き取った
後の面に乾燥状態でも抗菌性が持続し、しかも床ずれの
防止や院内感染の予防として有効なウェットワイパーを
提供するものである。銀系無機抗菌剤自体は、銀イオン
による抗菌効果のために乾燥状態で永続的に抗菌効果を
発揮することは知られていたが、銀系無機抗菌剤は２μ
m 程度の粒子のためにウェットワイパーに使用したとき
次のような問題があって使用できなかった。 (1) 銀系無機抗菌剤の微粒子が皮膚に付着して肌がかさ
かさになる。 (2) 銀系無機抗菌剤の比重が２．１〜２．２程度である
ので、それを配合した液では、銀系無機抗菌剤が直ちに
沈澱して均一な分散液として基材に均一状態で含浸させ
ることができなかった。 (3) 銀系無機抗菌剤の微粒子の凝集により拭いた部分が
白くなる。DISCLOSURE OF THE INVENTION The present invention provides a wet wiper which has an antibacterial property which remains on the surface after being wiped even in a dry state, and which is effective for preventing bed sores and preventing nosocomial infections. It has been known that the silver-based inorganic antibacterial agent itself exerts a permanent antibacterial effect in a dry state due to the antibacterial effect of silver ions, but the silver-based inorganic antibacterial agent is 2 μm.
When used for a wet wiper due to particles of about m, it could not be used due to the following problems. (1) Fine particles of the silver-based inorganic antibacterial agent adhere to the skin, making the skin bulky. (2) Since the specific gravity of the silver-based inorganic antibacterial agent is about 2.1 to 2.2, the solution containing the silver-based inorganic antibacterial agent immediately precipitates and becomes a uniform dispersion on the substrate. Could not be impregnated with. (3) The part wiped becomes white due to the aggregation of fine particles of the silver-based inorganic antibacterial agent.
【０００７】本発明者は、脂肪酸によって変性した変性
キトサン・コラーゲンを分散安定剤として用いることに
よって銀系無機抗菌剤の微粒子が水に均一な安定分散液
とすることを見い出した。上記水分散液での銀系無機抗
菌剤の分散性が良好なために粒子の凝集がなく微分散し
ているので、対人用のウェットワイパーの含有液として
用いると、使用後に拭いた部分が白くなることがなくな
り、かつ、皮膚の表面にキトサン・コラーゲンによる保
湿性の被膜ができ、上記被膜に銀系無機抗菌剤の微粒子
が内包固定されるので、使用後の肌はしっとりと潤いが
保持されて微粒子による“がさつき感”を解消すること
ができることがわかった。また、上記キトサン・コラー
ゲンに代えて、保護コロイド、界面活性剤及びエチレン
グリコールの配合液を用いたときにも銀系無機抗菌剤の
微粒子は水又は油類に均一の分散が可能となり、これを
対物用のワイパーの含有液として用いたときには清拭面
に潤い、又は保湿性とすることができ、かつ、使用後に
拭いた部分が白くなることのないことがわかった。The present inventor has found that by using modified chitosan collagen modified with fatty acid as a dispersion stabilizer, fine particles of a silver-based inorganic antibacterial agent form a stable dispersion in water. Since the dispersibility of the silver-based inorganic antibacterial agent in the aqueous dispersion is good and the particles are finely dispersed without aggregation, when used as a liquid containing a wet wiper for humans, the part wiped after use becomes white. And a moisturizing coating with chitosan / collagen is formed on the surface of the skin, and fine particles of the silver-based inorganic antibacterial agent are encapsulated and fixed in the above-mentioned coating, so the skin after use is kept moist and moist. It was found that the "gritty feeling" caused by the fine particles can be eliminated. Further, when a protective colloid, a surfactant, and a mixed solution of ethylene glycol are used instead of the chitosan collagen, the fine particles of the silver-based inorganic antibacterial agent can be uniformly dispersed in water or oils. It was found that when used as a liquid containing a wiper for an object, the wiped surface can be moistened or moisturized, and the wiped part does not become white after use.
【０００８】銀系無機抗菌剤は人体安全性の高い抗菌剤
として既に知られているが、本発明では、有効成分とし
てこの銀系無機抗菌剤を含む配合を含有させたウェット
ワイパーで拭いた身体部分の抗菌効果が長く持続するの
で、老人や病人の床ずれや排便などの防臭、その他の有
害菌による感染に対する予防にきわめて有効である。ま
た、本発明のウェットワイパーで物体を拭ったときに
は、従来のワイパーと異なり、拭いた部分は落下菌に対
して継続的な殺菌効果を有するので、雑菌の付着する病
院、食品工場や製薬工場における有効なウェットワイパ
ーとして使用することができるが、また乾燥状態のドラ
イワイパーとしても使用して抗菌効果を得ることができ
る。本発明における有効成分の銀系無機抗菌剤を含む分
散液を基材に含有させるとは、基材に含浸させたままの
ウェットの状態、あるいは適宜、乾燥させた後のドライ
の状態の両方の態様を意味する。このような銀系無機抗
菌剤の抗菌性の長期持続は他の抗菌剤の使用のときに比
して予期し得ない絶大な効果を発揮する。The silver-based inorganic antibacterial agent is already known as a human body-safe antibacterial agent, but in the present invention, the body wiped with a wet wiper containing a composition containing this silver-based inorganic antibacterial agent as an active ingredient. Since the antibacterial effect of the part lasts for a long time, it is extremely effective for deodorizing the elderly and sick people such as bed sores and defecation, and for preventing infection by other harmful bacteria. Further, when the object is wiped with the wet wiper of the present invention, unlike the conventional wiper, the wiped part has a continuous bactericidal effect against falling bacteria, so in hospitals where various bacteria adhere, in food factories and pharmaceutical factories. Although it can be used as an effective wet wiper, it can also be used as a dry wiper in a dry state to obtain an antibacterial effect. Including a dispersion containing a silver-based inorganic antibacterial agent as an active ingredient in the present invention in a substrate means that the substrate is in a wet state as it is impregnated, or if appropriate, in a dry state after being dried. Means an embodiment. The long-term sustainability of the antibacterial properties of such a silver-based inorganic antibacterial agent exerts an unexpectedly great effect as compared with the case of using other antibacterial agents.
【０００９】[0009]
【課題を解決するための手段】本発明では、脂肪酸によ
ってキトサン及びコラーゲンを変性した変性キトサン・
コラーゲン液を用いて銀系無機抗菌剤の微粒子を水に均
一な安定分散液として基材に含浸することによって対人
用ウェットワイパーとする。変性キトサン・コラーゲン
を用いると、銀系無機抗菌剤粒子の分散性が良くなるた
めに粒子の凝集がなく、微分散するので、使用後に拭い
た部分が白くなることはなく、また皮膚の表面に変性キ
トサン・コラーゲンによって銀系無機抗菌剤の微粒子が
内包固定された保湿性の被膜ができるので、使用後の肌
はしっとりと潤いが保持されて、拭いた後の肌に持久性
のある抗菌性が得られ微粒子によるがさつき感を解消す
ることにより従来の問題点を解決した。In the present invention, a modified chitosan obtained by modifying chitosan and collagen with a fatty acid is used.
A wet wiper for personal use is obtained by impregnating a base material with fine particles of a silver-based inorganic antibacterial agent in water as a uniform and stable dispersion liquid using a collagen liquid. When denatured chitosan / collagen is used, the dispersibility of the silver-based inorganic antibacterial agent particles is improved, and the particles do not aggregate and are finely dispersed, so the part wiped after use does not become white and the surface of the skin does not A denatured chitosan / collagen creates a moisturizing film in which fine particles of a silver-based inorganic antibacterial agent are encapsulated and fixed, so the skin after use retains moistness and moisture, and the antibacterial property is durable on the skin after wiping. Thus, the conventional problems were solved by eliminating the feeling of roughness caused by fine particles.
【００１０】即ち、本発明では中液を基材に含浸した後
に基材を乾燥した場合、銀系無機抗菌剤が変性キトサン
・コラーゲン被膜によって基材に固定されて含有され
る。従来のように、アクリル系等の合成樹脂バインダー
によって固定するのと異なり、柔軟であり、衛生面で安
全である上に変性キトサン・コラーゲンによる固定は調
整が容易であり、銀系無機抗菌剤が清拭面に付着し、清
拭面の長期間の抗菌性を得ることができる。本発明で得
られたウェットワイパーは、含浸後の基材を折りたたみ
ピロー包装をするか容器にいれて密封することが好まし
い。また上記基材をロール巻して容器に密封してもよ
い。また、対物用のウェットワイパーでは、拭いた面に
潤いを持たせたり保湿性にすることはかえって雑菌が付
着しやすくなるので、キトサン・コラーゲンの使用は好
ましくない。そこで、この場合には銀系無機抗菌剤の微
粒子を安定した均一分散にするために、保護コロイド、
界面活性剤及びエチレングリコールの配合液を用いて、
水、又油類に対して均一分散を可能とすることにより、
使用後に拭いた部分が白くなることがなく、清浄効果の
すぐれたワイパーが得られるのである。またウェット状
態を乾燥したドライワイパーとして使用した時にも清拭
面において同様の効果を発揮する。That is, in the present invention, when the base material is dried after impregnating the base material with the medium solution, the silver-based inorganic antibacterial agent is fixed and contained in the base material by the modified chitosan / collagen coating. Unlike conventional fixing with synthetic resin binder such as acrylic type, it is flexible and hygienic safe, and fixing with modified chitosan / collagen is easy to adjust, and silver-based inorganic antibacterial agent It adheres to the wiped surface and can obtain the long-term antibacterial property of the wiped surface. The wet wiper obtained in the present invention is preferably folded and pillow-wrapped with the base material after impregnation or put in a container and sealed. The base material may be rolled and sealed in a container. Further, in the case of a wet wiper for an object, it is not preferable to use chitosan / collagen because moisturizing or moisturizing the wiped surface tends to easily attach various bacteria. Therefore, in this case, in order to make the fine particles of the silver-based inorganic antibacterial agent stable and uniform, a protective colloid,
Using a mixture of surfactant and ethylene glycol,
By allowing uniform dispersion in water and oils,
The wiped part does not become white after use, and a wiper with an excellent cleaning effect can be obtained. Further, when the wet state is used as a dry wiper, the same effect is exhibited on the wiped surface.
【００１１】銀イオンは、いわゆる“抗菌スペクトル”
が広く、特に緑膿菌に有効であるので、床ずれの予防に
効果的である。このため介護用として身体を拭くことに
よって緑膿菌や防臭に対して大きな効果を発揮する。こ
の発明において、脂肪酸で変性した可溶性の変性キトサ
ン・コラーゲンを使用したときには、銀系無機抗菌剤の
安定分散を得る効果の他に変性キトサン・コラーゲンが
肌の表面に保湿性の被膜を作るので、銀系無機抗菌剤が
被膜に固定、保持されて持続性のある抗菌効果を発揮す
る。Silver ion is a so-called "antibacterial spectrum".
Is effective against Pseudomonas aeruginosa, so it is effective in preventing bed sores. For this reason, wiping the body as a care product exerts a great effect on Pseudomonas aeruginosa and deodorization. In the present invention, when soluble modified chitosan / collagen modified with fatty acid is used, modified chitosan / collagen forms a moisturizing film on the surface of the skin in addition to the effect of obtaining a stable dispersion of the silver-based inorganic antibacterial agent. The silver-based inorganic antibacterial agent is fixed and retained on the film to exert a long-lasting antibacterial effect.
【００１２】本発明における銀系無機抗菌剤は、銀ゼオ
ライト、銀燐酸ジルコニウム、銀アパタイト等のイオン
交換された銀系無機化合物を使用する。そして水分散液
中に無機抗菌剤の分散を安定にするために、キトサン及
びコラーゲンを脂肪酸によって変性した可溶性キトサン
・コラーゲンを０．０５〜５重量％を含む水分散液を基
材に含浸させたワイパーは対人用に用いることが好まし
い。この発明で用いる変性キトサン・コラーゲンにする
調製法は、キトサン粉末１部にヤシ油脂肪酸８部を撹拌
混合して８０℃で２０時間撹拌反応させ、次いで６０℃
に２部の加水分解コラーゲンを加えて３時間撹拌反応さ
せて室温に放置するのが適当である。The silver-based inorganic antibacterial agent in the present invention uses ion-exchanged silver-based inorganic compounds such as silver zeolite, silver zirconium phosphate, and silver apatite. Then, in order to stabilize the dispersion of the inorganic antibacterial agent in the aqueous dispersion, the substrate was impregnated with an aqueous dispersion containing 0.05 to 5% by weight of soluble chitosan-collagen obtained by modifying chitosan and collagen with a fatty acid. The wiper is preferably used for personal use. The modified chitosan / collagen used in the present invention is prepared by mixing 1 part of chitosan powder with 8 parts of coconut oil fatty acid with stirring, reacting at 80 ° C. for 20 hours with stirring, and then at 60 ° C.
It is suitable to add 2 parts of hydrolyzed collagen to the mixture, stir to react for 3 hours, and leave at room temperature.
【００１３】また、上記変性キトサン・コラーゲンに代
えて保護コロイドを０．０５重量％以上、界面活性剤
０．０５重量％以上及びエチレングリコール０．１重量
％以上を含む配合液を使用することもできる。この配合
液を分散安定剤として用いたときには、銀系無機抗菌剤
を基材に含有させものは対物用ワイパーとして用いるの
が適当である。このときの保護コロイドには、ＰＶＡ、
ＣＭＣ、可溶性コラーゲン等の親水性ポリマーを用いる
のが適当である。また、界面活性剤は別に特定されない
が、非イオン界面活性剤、両性界面活性剤等の起泡性の
少ないものが使い易く、０．０５重量％以上好ましくは
０．２〜０．６重量％加える。更にエチレングリコール
を０．１重量％以上配合することでドアーノブ等に付着
する皮脂等による皮脂汚れ等を一層容易に除去すること
ができる。Further, instead of the above modified chitosan / collagen, it is also possible to use a compounding solution containing 0.05% by weight or more of a protective colloid, 0.05% by weight or more of a surfactant and 0.1% by weight or more of ethylene glycol. it can. When this compounded liquid is used as a dispersion stabilizer, it is suitable to use a compound containing a silver-based inorganic antibacterial agent in a base material as an objective wiper. The protective colloid at this time is PVA,
It is suitable to use hydrophilic polymers such as CMC and soluble collagen. The surfactant is not particularly specified, but non-ionic surfactants, amphoteric surfactants, and the like having a low foaming property are easy to use, and 0.05% by weight or more, preferably 0.2 to 0.6% by weight. Add. Further, by blending ethylene glycol in an amount of 0.1% by weight or more, sebum stains and the like due to sebum adhering to the door knob and the like can be removed more easily.
【００１４】以下に、本発明の実施例を説明するが、本
発明は実施例に限定されるものではない。Examples of the present invention will be described below, but the present invention is not limited to the examples.
【実施例１】綿１００重量％不織布を基材とし、２００
mm×２００mmに裁断して折り畳み、６０枚を重ねて基材
とした。一方、銀ゼオライト（ＡＪ−１０Ｎ、株式会社
シナネンゼオミック製品）０．５重量％を精製水に撹拌
分散させ超音波にて２分間処理して分散をよくした。こ
れにヤシ油脂肪酸によって予め変性処理したキトサン・
コラーゲンを０．５重量％を撹拌添加して、超音波を２
分間当てて分散液とした。前記不織布重量の３．５倍量
の上記水分散液を、不織布に含浸せしめてウェットワイ
パーとし、直ちに気密性シートを用いた開閉蓋付きのピ
ロー包装を行った。上記水溶液の緑膿菌に対する最小発
育阻止濃度（ＭＩＣ）は32ppm であった。ガラス板をピ
ロー包装内の上記ウェットワイパーで拭き取り、その面
が乾燥してから緑膿菌を、上記清拭面に対して１．７×
１０5 を植菌してＡＡＴＣＣ L14.144-1965Tに基づく菌
数測定を行った結果、菌数はゼロであった。上記ウェッ
トワイパーで肌を拭いた結果、汚れがよく除去され、皮
膚は潤いが保たれ快適であった。また肌を拭いた後で臭
気の発生することはなかった。Example 1 A non-woven fabric made of 100% by weight cotton was used as a base material, and 200
mm × 200 mm, cut and folded, and 60 sheets were piled up to obtain a base material. On the other hand, 0.5% by weight of silver zeolite (AJ-10N, Sinanene Zeomic product) was stirred and dispersed in purified water and treated with ultrasonic waves for 2 minutes to improve dispersion. Chitosan pre-modified with coconut oil fatty acid
Add 0.5% by weight of collagen with stirring and sonicate to 2
The dispersion was applied by applying for 1 minute. A non-woven fabric was impregnated with 3.5 times the weight of the above-mentioned non-woven fabric to form a wet wiper, which was immediately subjected to pillow packaging with an opening / closing lid using an airtight sheet. The minimum inhibitory concentration (MIC) of the above aqueous solution against Pseudomonas aeruginosa was 32 ppm. Wipe the glass plate with the above-mentioned wet wiper in the pillow package, and after the surface is dried, Pseudomonas aeruginosa is applied to the above-mentioned wiped surface by 1.7 ×.
As a result of inoculating 10 5 and measuring the number of bacteria based on AATCC L14.144-1965T, the number of bacteria was zero. As a result of wiping the skin with the above wet wiper, stains were well removed, and the skin was kept moist and comfortable. Moreover, no odor was generated after the skin was wiped.
【００１５】[0015]
【比較例１】基材に含浸する中液として、（イ）塩化セ
チルピリジニウム０．０５重量％、プロピレングリコー
ル１０重量％、パラオキシ安息香酸メチルエステル０．
２３重量％、パラオキシ安息香酸エチルエステル０．０
９重量％、精製水８９．６８重量％の水溶液を上記不織
布に、不織布重量の３．５倍量を含浸せしめて直ちに気
密性シートによりピロー包装を行った。 （ロ）アルコール７重量％、パラオキシ安息香酸メチル
エステル０．２重量％、香料０．０５重量％、精製水９
２．７５重量％水溶液を前記不織布に不織布重量の３．
５倍量を含浸せしめて直ちに気密性シートによりピロー
包装を行った。 （イ）及び（ロ）の２種類のウェットワイパーによりそ
れぞれ別々にガラス板を拭きとり、その面が乾燥してか
ら緑膿菌を１．７×１０5 を植菌してＡＡＴＣＣ L14,1
44-1965Tに基づいて菌数測定を行った結果、（イ）では
２．４×１０6個／mLの緑膿菌が測定され、（ロ）では
５．３×１０7 個／mLの緑膿菌が測定され拭きとった面
に抗菌効果は得られなかった。[Comparative Example 1] As a medium solution for impregnating a base material, (a) 0.05% by weight of cetylpyridinium chloride, 10% by weight of propylene glycol, and methyl paraoxybenzoate (0.1% by weight).
23% by weight, para-oxybenzoic acid ethyl ester 0.0
The nonwoven fabric was impregnated with an aqueous solution of 9% by weight and 89.68% by weight of purified water in an amount of 3.5 times the weight of the nonwoven fabric, and immediately subjected to pillow packaging with an airtight sheet. (B) Alcohol 7% by weight, paraoxybenzoic acid methyl ester 0.2% by weight, fragrance 0.05% by weight, purified water 9
2.75% by weight aqueous solution was added to the above-mentioned non-woven fabric to 3.
Immediately after being impregnated with a 5-fold amount, pillow packaging was performed with an airtight sheet. Separately wipe the glass plate with two types of wet wiper (a) and (b), and after the surface is dried, inoculate 1.7 x 10 5 of Pseudomonas aeruginosa into AATCC L14,1
As a result of measuring the number of bacteria based on 44-1965T, 2.4 × 10 6 cells / mL of Pseudomonas aeruginosa was measured in (a) and 5.3 × 10 7 cells / mL of green in (b). No antibacterial effect was obtained on the surface wiped with Pseudomonas aeruginosa.
【００１６】[0016]
【実施例２】綿５０重量％、レーヨン５０重量％不織布
を幅１２０mmのロールに巻ながら２００mm毎にミシン目
を入れてロール巻の基材とした。一方、銀ゼオライト
（ＡＷ−１０Ｎ、株式会社シナネンゼオミック製品）
０．３重量％、ＰＶＡ０．１重量％、エチレングリコー
ル０．３重量％、ポリオキシエチレン（７）セチルエー
テル０．１重量％を精製水に撹拌混合して超音波を２分
間処理して微分散液とした。上記基材に上記水分散液の
不織布重量の３倍量を含浸し、ウェットワイパーとし
て、これを直ちに、プラスチックボトルに封入し、密閉
包装した。このプラスチックボトル内のウェットワイパ
ーを用いてＰＥＴ板を拭いて２４時間後に、黄色ブドウ
球菌を２．７×１０4 植菌してＡＡＴＣＣ L14,144-196
5Tに基づく菌数測定を行った結果、菌数はゼロであっ
た。Example 2 A nonwoven fabric made of 50% by weight cotton and 50% by weight rayon was wound around a roll having a width of 120 mm and perforated every 200 mm to obtain a roll-wound base material. On the other hand, silver zeolite (AW-10N, Sinanene Zeomic Co., Ltd.)
0.3% by weight, PVA 0.1% by weight, ethylene glycol 0.3% by weight, and polyoxyethylene (7) cetyl ether 0.1% by weight were stirred and mixed in purified water, and ultrasonic waves were treated for 2 minutes to be slightly mixed. It was a dispersion liquid. The above base material was impregnated with 3 times the weight of the non-woven fabric of the above aqueous dispersion and used as a wet wiper, which was immediately sealed in a plastic bottle and hermetically sealed. 24 hours after wiping the PET plate with the wet wiper in this plastic bottle, 2.7 × 10 4 Staphylococcus aureus was inoculated and AATCC L14,144-196
As a result of measuring the number of bacteria based on 5T, the number of bacteria was zero.
【００１７】[0017]
【比較例２】基材に含浸する中液として、アルコール７
重量％、パラオキシ安息香酸メチルエステル０．２重量
％、香料０．０５重量％、精製水９２．７５重量％の水
溶液を上記不織布に、不織布重量の３．５倍量を含浸せ
しめて直ちに気密性シートによりピロー包装を行った。
その中身のウェットワイパーを用いて、上記と同様にＰ
ＥＴ板の表面を拭いて２４時間後に黄色ブドウ球菌を
２．７×１０4 植菌してＡＡＴＣＣ L14,144-1965Tに基
づいて菌数を測定した結果、１．５×１０6 個／mLに菌
の増殖が認められた。Comparative Example 2 Alcohol 7 was used as a medium solution for impregnating a base material.
Immediately airtightness is obtained by impregnating the above nonwoven fabric with an aqueous solution containing 0.2% by weight of paraoxybenzoic acid methyl ester, 0.05% by weight of perfume, and 92.75% by weight of purified water. Pillow wrapping was performed with the sheet.
Using the contents of the wet wiper, P
After wiping the surface of the ET plate, after 24 hours, 2.7 × 10 4 Staphylococcus aureus was inoculated and the number of bacteria was measured based on AATCC L14,144-1965T. As a result, 1.5 × 10 6 cells / mL were obtained. Bacterial growth was observed.
【００１８】[0018]
【実施例３】銀ゼオライト（ＡＪ−１０Ｎ、株式会社シ
ナネンゼオミック製品）０．５重量％、加水分解コラー
ゲン０．１重量％、エチレングリコール０．５重量％、
ポリオキシエチレン（７）セチルエーテル０．１重量％
になるように、ノルマルヘキサンとシクロヘキサンの
１：１の混合液を加えて調整した。混合液は超音波によ
り３分間処理して分散性をよくして中液とした。上記中
液をレーヨン５０重量％及びポリエステル５０重量％よ
りなる不織布（２５g ／ｍ2)に含浸し、不織布重量の１
００重量％の付与率になるようにマングルで均一に絞液
してピロー包装を行って油性のウェットワイパーを作成
した。従来技術によるブランクとして、エチレングリコ
ール０．５重量％、ポリオキシエチレン（７）セチルエ
ーテル０．１重量％になるように、ノルマルヘキサンと
シクロヘキサンの１：１の混合液を加えて調整した液
を、レーヨン５０重量％及びポリエステル５０重量％よ
りなる不織布に含浸し、不織布重量の１００重量％の付
与率になるようにマングルで均一に絞液してピロー包装
を行った。予め病室の床で一般細菌として１．８×１０
4 個／２５cm2 にあることを測定して確認後、上記ワイ
パーを用いて、上記床を拭いて２日後の落下菌数を測定
した結果、本発明によるワイパーでは一般細菌数は１０
2 個以下／２５cm2 であり、ブランクでは３．０×１０
4 個／２５cm2 であった。[Example 3] 0.5% by weight of silver zeolite (AJ-10N, Sinanene Zeomic Co., Ltd.), 0.1% by weight of hydrolyzed collagen, 0.5% by weight of ethylene glycol,
Polyoxyethylene (7) cetyl ether 0.1% by weight
Was adjusted by adding a 1: 1 mixture of normal hexane and cyclohexane. The mixed solution was treated with ultrasonic waves for 3 minutes to improve the dispersibility and was made into a medium solution. A non-woven fabric (25 g / m 2 ) composed of 50% by weight of rayon and 50% by weight of polyester was impregnated with the above-mentioned medium solution, and
An oily wet wiper was prepared by uniformly squeezing the solution with a mangle so that the application rate was 00% by weight, and performing pillow packaging. As a blank according to the conventional technique, a solution prepared by adding a 1: 1 mixture of normal hexane and cyclohexane so that ethylene glycol 0.5% by weight and polyoxyethylene (7) cetyl ether 0.1% by weight was prepared. A non-woven fabric composed of 50% by weight of rayon and 50% by weight of polyester was impregnated and uniformly squeezed with a mangle so that the application rate was 100% by weight of the non-woven fabric, followed by pillow packaging. 1.8 × 10 as general bacteria on the floor of the hospital room
After confirming by measuring 4 cells / 25 cm 2 , the above wiper was used to wipe the floor and the number of dropped bacteria after 2 days was measured. As a result, the wiper according to the present invention had a general bacterial count of 10
2 pieces or less / 25 cm 2 , 3.0 × 10 in blank
It was 4 pieces / 25 cm 2 .
【００１９】[0019]
【実施例４】銀ゼオライト（ＡＧ−１０Ｎ、株式会社シ
ナネンゼオミック製品）０．８重量％を精製水に撹拌分
散させ超音波を用いて２分間処理した。次いで、上記分
散液にヤシ油脂肪酸によってキトサンとコラーゲンを変
性処理した薬液を０．８重量％撹拌添加して２分間超音
波処理して分散をよくした分散液を綿１００重量％のよ
りなる不織布に含浸し、マングルを用いて絞り率を１０
０重量％となるように絞液して、９０℃で乾燥した。乾
燥状態の上記不織布を用いて病室内のテーブルを拭いて
黄色ブドウ球菌を１．５×１０5 個植菌した結果、１日
後の菌数は０．８×１０2 個／２５cm2 に低下し、比較
として一般のティッシュペーパーで拭いた部分では３．
４×１０6 個／２５cm2 に増加した。乾燥状態の上記不
織布は含浸させたままの状態ではウェットワイパーとし
て使用できるが、それを乾燥させた状態でも、機器類の
抗菌性のワイパーとして使用できた。Example 4 0.8% by weight of silver zeolite (AG-10N, Sinanene Zeomic Co., Ltd.) was stirred and dispersed in purified water and treated with ultrasonic waves for 2 minutes. Next, a chemical solution in which chitosan and collagen were modified with coconut oil fatty acid was added to the above dispersion with stirring at 0.8% by weight, and ultrasonically treated for 2 minutes to improve dispersion. Impregnate it with a mangle to reduce the draw ratio to 10
The solution was squeezed to 0% by weight and dried at 90 ° C. Dry wipe tables in a hospital room by using the nonwoven fabric results inoculated 1.5 × 10 5 pieces of Staphylococcus aureus, bacterial count after 1 day decreased to 0.8 × 10 2 cells / 25 cm 2 For comparison, in the part wiped with general tissue paper, 3.
It increased to 4 × 10 6 pieces / 25 cm 2 . The above-mentioned non-woven fabric in a dried state could be used as a wet wiper in a state of being impregnated, but even in a dried state, it could be used as an antibacterial wiper for devices.
Claims (4)
定分散した分散液を基材に均一に含有せしめたことを特
徴とする抗菌性ワイパー。1. An antibacterial wiper, characterized in that a dispersion liquid in which 0.05 to 5% by weight of a silver-based inorganic antibacterial agent is stably dispersed is uniformly contained in a substrate.
ラーゲンを使用することを特徴とする請求項１の抗菌性
ワイパー。2. The antibacterial wiper according to claim 1, wherein soluble chitosan collagen is used as the dispersion stabilizer.
した可溶性キトサン・コラーゲンを使用する請求項１の
抗菌性ワイパー。3. The antibacterial wiper according to claim 1, wherein chitosan and soluble chitosan collagen obtained by modifying collagen with fatty acid are used.
５重量％以上、界面活性剤０．０５重量％以上及びエチ
レングリコール０．１重量％以上の配合液を使用するこ
とを特徴とする請求項１の抗菌性ワイパー。4. A protective colloid 0.0 as a dispersion stabilizer.
The antibacterial wiper according to claim 1, wherein a compounded solution containing 5% by weight or more, a surfactant of 0.05% by weight or more, and ethylene glycol of 0.1% by weight or more is used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2739095A JP3187676B2 (en) | 1995-01-23 | 1995-01-23 | Antibacterial wiper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2739095A JP3187676B2 (en) | 1995-01-23 | 1995-01-23 | Antibacterial wiper |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08196461A true JPH08196461A (en) | 1996-08-06 |
| JP3187676B2 JP3187676B2 (en) | 2001-07-11 |
Family
ID=12219740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2739095A Expired - Fee Related JP3187676B2 (en) | 1995-01-23 | 1995-01-23 | Antibacterial wiper |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3187676B2 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11155754A (en) * | 1997-12-02 | 1999-06-15 | Pigeon Corp | Method for reducing adsorbing amount of anti-fungus and anti-mildew agent |
| WO2000049219A1 (en) * | 1999-02-20 | 2000-08-24 | Foxwood Research Limited | Substrates with biocidal properties and process for making them |
| JP2000265343A (en) * | 1999-03-19 | 2000-09-26 | Toray Ind Inc | Wiping cloth and its production |
| JP2001020150A (en) * | 1999-07-08 | 2001-01-23 | Toray Ind Inc | Wiping cloth and its production |
| WO2001034897A1 (en) * | 1999-11-11 | 2001-05-17 | Moritoshi Co., Ltd. | Fiber-treating agent and fiber |
| WO2002094224A1 (en) * | 2001-05-23 | 2002-11-28 | Institut National De La Recherche Scientifique | Biocompatible compositions as carriers or excipients for pharmaceutical and nutraceutical formulations and for good protection |
| US6860967B2 (en) | 2001-01-19 | 2005-03-01 | Sca Hygiene Products Gmbh | Tissue paper penetrated with softening lotion |
| US6905697B2 (en) | 2001-01-19 | 2005-06-14 | Sca Hygiene Products Gmbh | Lotioned fibrous web having a short water absorption time |
| JP2009024274A (en) * | 2007-07-19 | 2009-02-05 | Kenji Nakamura | Sheet for impregnation, and wet sheet product using the same |
| CN106215222A (en) * | 2016-07-07 | 2016-12-14 | 四川大学 | A kind of aoxidize oligochitosan crosslinked with collagen and method that in-situ preparation nanometer silver prepares antimicrobial form collagen |
-
1995
- 1995-01-23 JP JP2739095A patent/JP3187676B2/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11155754A (en) * | 1997-12-02 | 1999-06-15 | Pigeon Corp | Method for reducing adsorbing amount of anti-fungus and anti-mildew agent |
| WO2000049219A1 (en) * | 1999-02-20 | 2000-08-24 | Foxwood Research Limited | Substrates with biocidal properties and process for making them |
| JP2000265343A (en) * | 1999-03-19 | 2000-09-26 | Toray Ind Inc | Wiping cloth and its production |
| JP2001020150A (en) * | 1999-07-08 | 2001-01-23 | Toray Ind Inc | Wiping cloth and its production |
| WO2001034897A1 (en) * | 1999-11-11 | 2001-05-17 | Moritoshi Co., Ltd. | Fiber-treating agent and fiber |
| US6860967B2 (en) | 2001-01-19 | 2005-03-01 | Sca Hygiene Products Gmbh | Tissue paper penetrated with softening lotion |
| US6905697B2 (en) | 2001-01-19 | 2005-06-14 | Sca Hygiene Products Gmbh | Lotioned fibrous web having a short water absorption time |
| US8545861B2 (en) | 2001-01-19 | 2013-10-01 | Sca Hygiene Products Gmbh | Lotioned fibrous web having a short water absorption time |
| WO2002094224A1 (en) * | 2001-05-23 | 2002-11-28 | Institut National De La Recherche Scientifique | Biocompatible compositions as carriers or excipients for pharmaceutical and nutraceutical formulations and for good protection |
| JP2009024274A (en) * | 2007-07-19 | 2009-02-05 | Kenji Nakamura | Sheet for impregnation, and wet sheet product using the same |
| CN106215222A (en) * | 2016-07-07 | 2016-12-14 | 四川大学 | A kind of aoxidize oligochitosan crosslinked with collagen and method that in-situ preparation nanometer silver prepares antimicrobial form collagen |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3187676B2 (en) | 2001-07-11 |
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