JPH0261000A - Composition containing antiseptic for impregnation of nonwoven wipe - Google Patents

Abstract

PURPOSE: To obtain an aqueous composition for impregnating a soft nonwoven wipe for purifying an organism or an inanimate matter by blending a specified compound and a specified cationic biocide to a preservative component consisting of potassium sorbate and citric acid.

CONSTITUTION: An aqueous composition for impregnating nonwoven wipe which is formed of (A) about 0.02-0.25 wt.% (hereinafter referred to as %) of potassium sorbate, (B) about 0.05-0.20% of citric acid, (C) about 0.02-0.20% of disodium ethylenediaminetetraacetate, (D) about 0.03-0.24% of a cationic biocide consisting of (a) polyhexamethylene biguanide hydrochloride or (b) poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylenedichloride], and (E) the remainder of water and has a pH of about 3.5-4.5 is manufactured. The compounds C and D are contained in the preservative component consisting of the compounds A and B, whereby a nonwoven wipe containing no alcohol and having no slippery feeling can be manufactured.

COPYRIGHT: (C)1990,JPO

Description

Detailed Description of the Invention (Field of Industrial Application) The present invention provides a novel non-woven wet wipe.
), more specifically impregnated wipe antiseating agent (ρreser
The present invention relates to a non-woven wipe impregnated with an aqueous, non-alcoholic composition comprising potassium sorbate and citric acid.

BACKGROUND OF THE INVENTION Various forms of nonwoven impregnated webs have been used for a wide variety of tasks, such as cleaning hard surfaces, cleaning hands and other areas of the body, and a variety of surfaces - both animate and inanimate. It has been suggested that the active ingredient is added to □.

For nonwoven impregnated wipes prepared for cleaning hands and skin surfaces, the ingredients are generally aqueous based. Wipes of this type are commercially available ready for immediate use in individual packets or in bulk in suitable dispensers from which individual wipes can be removed as needed. Regardless of the form of packaging, wipes are stored for a substantial period of time before use and are therefore susceptible to microbial contamination,
and need to be protected against the deterioration to which they are susceptible. One common method for doing this is to include a suitable chemical preservative system in the liquid composition used to impregnate the nonwoven wipe.

A typical system used in many aqueous impregnating compositions for nonwoven wipes includes ethyl alcohol, which is well known for its preservative properties. One of this kind of preservative system giving excellent results
One consists of sorbic acid, citric acid and ethyl alcohol. However, ethyl alcohol is generally used at concentrations greater than 5% by weight of the impregnating composition.

Currently, there is a trend toward formulating impregnating compositions for nonwoven wipes that avoid the use of ethyl alcohol.

The reason is that many consumers prefer alcohol-free wipes, especially those who want to use them primarily for personal hygiene, especially heavy-duty cleaning wipes, which have a significant market.
This is because we are thinking about the manufacturing industry of moist) wipes. However, when removing ethyl alcohol from sorbic acid-citric acid-ethyl alcohol preservative systems for nonwoven wipes, combinations containing only sorbic acid and citric acid do not necessarily provide adequate protection against microbial contamination and deterioration. A problem arises in this respect.

U.S. Pat. No. 4,732,797 IB describes a fibrous wipe consisting essentially of a mixture of ingredients selected from citric and sorbic acids as preservative ingredients, water, and optionally skin moisturizers and fragrances. A liquid preservative composition for wiper is shown.

Wipers containing cationic antimicrobials may be used, for example, in U.S. Pat. No. 3,264,188.4.6, discussed below.
No. 15,937 and No. 4,678,704.

U.S. Pat. No. 3,264,188 describes a cosmetic crepe tissue containing mineral oil and an emulsifier, such as triethanolamine oleate, dispersed throughout.
A sanitary impregnated skin wiper for anal material is shown which may contain a bacteriostatic agent, with benzalkonium chloride being the preferred bacteriostatic agent.

U.S. Pat. No. 4,615,937 discloses an antimicrobially active nonwoven web in which the antimicrobial agent is applied substantially to both the fibers and the binder within the web, preferably an organic It is a silicon-based quaternary ammonium salt.

U.S. Pat. No. 4,678,704 discloses a fabric support, which may be woven or nonwoven, containing an active cationic impregnant and an anionic indicator dye along with other cationic components. Impregnated fabric materials are shown bonded together.

Nonionic surfactants, chelating agents and perfumes may also be included in the impregnated fabric. Examples of cationic materials described are quaternary ammonium compounds, bisguanides, and polymeric bisguanides such as polyhexamethylene bisguanide hydrochloride, which is described in U.S. Pat. No. 4,587,266, Hexamethylene biguanide hydrochloride can be used in antimicrobial compositions in combination with certain amine oxides. Polyhexamethylene biguanide hydrochloride is stated to be commercially available from ICI Americans, Inc. under the trade name Cosmocil CQ.

The main ingredients and functions of body cleaning wipe products currently on the market are listed below.

PEG-75 Lanolin” Softens the skin *Average 7
Polyethylene Glycol Derivatives of Lanolin Containing 5 Moles of Ethylene Oxide (Summary of the Invention) To enhance the antimicrobial action of a combination of sorbic acid and citric acid in a preservative system for wet nonwoven wipes,
Since it is well known that various commercially available cationic biocides have substantial effects on nonwoven fabrics, we investigated their inclusion in the preservative system. Unfortunately, the presence of cationic biocides imparted an undesirable slipperry feel to impregnated nonwoven wipes, especially those whose fiber component contained a significant proportion of rayon or rayon-polyester blend. However, it has been found that the slippery feel of wet wipes can be significantly suppressed by containing either of two specific cationic bionides.

Accordingly, in one aspect of the invention, potassium sorbate is about 0.02% to about 0.25% by weight, and citric acid is about 0.05% to about 0.25% by weight.
about 0.20% by weight, about 0.02 to about 0.20% airtrium ethylenediaminetetraacetate, (a) polyhexamethylene biguanide hydrochloride or ([)) poly(oxyethylene(dimethyliminio)ethylene ( from about 0.03% to about 0.24% by weight of a cationic biocide which is ethylene chloride]; and the balance to 100% by weight water, such that the p++ of the composition is about 3.
5 to about 4.5 is provided.

In another aspect of the invention, there is provided a wet wipe comprising a flexible absorbent nonwoven support impregnated with an aqueous composition as defined in item 1 above.

The aqueous compositions of the present invention are used as impregnating agents for flexible absorbent nonwoven fabrics in the production of wet wipes useful for cleaning and/or applying active agents to living or inanimate surfaces.

The composition comprises water containing a dissolved preservative system specifically tailored to prevent microbial deterioration of wet wipes that are susceptible to microbial deterioration in the absence of a suitable preservative. The preservative system consists of potassium sorbate, airtrium ethylenediaminetetraacetate (disodium EDTA), a cationic biocide selected from the two specific agents detailed above, and citric acid.

Potassium sorbate is present in the aqueous composition at about 0% of the aqueous composition.
．． It is used at a concentration of 0.02% to about 0.25% by weight.

The antimicrobial effect contributed by sorbate is primarily due to the pl+
This is due to sorbic acid modified in situ at levels.

Airtrium ethylenediaminetetraacetate enhances the effectiveness of preservative systems. It is used at a concentration of about 0.02 to about 0.20 weight percent of the composition.

Cationic biosides include polyhexamethylene biguanide hydrochloride and poly[oxyethylene (dimethyliminio) ethylene (dimethyliminio).

e) ethylene dichloride]. Polyhexamethylene biguanide hydrochloride is a known biocide with a broad spectrum of antimicrobial activity, and is commercially available as a 20% aqueous solution from TCI Americans, Wilmington, PR under the trade name Cohimocyl CQ. This can be expressed by the following general formula.

l1 In the formula, n has an average value such that the molecular weight is 1000 to 1400. Poly[oxyethylene (dimethyliminio)mo.

Ethylene (dimethyliminio)ethylene chloride is a known broad-spectrum antimicrobial compound available as a 60% aqueous concentrate from Bankman Laboratories, Inc. (Memphis, Tenn.) under the trade name wscp. It contains the following repeating units:

In the formula, n has an average value such that the molecular weight is 3000 to 4000.

The cationic biocide is about (1,03~
It is used at a concentration of about 0.24% (active ingredient).

The pH of the aqueous composition should be from about 3.5 to about 4.5, preferably from about 4.0 to about 4.3. As mentioned above, the antimicrobial activity resulting from the use of potassium sorbate is primarily due to the undissociated sorbic acid produced in situ in the 3.5-4.5 pl+ range. Citric acid is added to the pH in aqueous compositions.
As a regulator, the pH of the aqueous composition is from about 3.5 to about 4.5.
Used in ■ to ensure that the range is within the range of .

This range of pH ranges from about 0.05 to
obtained when used at a concentration of about 0.20%.

Depending on the particular application for the wipe impregnated with the aqueous composition of the present invention, any ingredient can be included in the aqueous 1M composition.

For example, wipes used to cleanse the skin may contain moisturizers (humecLant).
), such as propylene glycol, glycerin and sorbitol; emollients (sof Lner/e
organic compounds such as ethoxylated lanolin, ethoxylated glucose, silicone oils, mineral oils and fatty acid esters; plant extracts such as winch hazel extract, aloe vera gel and camifre extract;
e, fragrance). The concentration of this type of optional ingredient is 0.2 skin moisturizer based on the weight of the final composition.
~10% Kawama, emollients 0.02-5%, plant extracts 0. O1 to 50% heavy weight, and fragrance 0.01 to 2% heavy weight wax.

Aqueous compositions of the invention may also contain surfactants and detergents. Surfactants can be amphoteric, such as cocoamphodiacetate, which is commercially available from several companies, or nonionic, such as glycerin cocoate (glycerine cocoate), which is commercially available from several companies.
polyethylene glycol ether, polyoxyethylene polyoxypropylene carbon polymer, or polyoxyethylene and/or
or a polymer of dimethylsiloxane containing polyoxypropylene side chains, all of which are commercially available.

The surfactant should be added in an amount of 0.02 to 100% by weight based on the weight of the aqueous composition.
A concentration of 10% by weight will be used.

The support used in the wet wipes of the present invention consists essentially of cellulosic fibers or cellulosic fiber blends, such as rayon and cotton fibers, or these cellulosic fibers and one or more synthetic fibers, such as polypropylene, polyethylene, etc. , a fibrous, flexible, absorbent nonwoven sheet material consisting of a blend of polyester and nylon fibers. This type of blend also includes wood pulp fibers. To ensure that the final nonwoven sheet has adequate wet strength, a binder is commonly used to bond the fibers together. Binders of this type are, for example, acrylic polymers, ethylene-+% vinyl polymers, vinyl acetate copolymers and styrene-butadiene polymers. Nonwoven materials of this type and methods of making them are well known in the art.

Manufacturing methods for this type of nonwoven sheet material include carding, airflow deposition, water jet entanglement, thermal bonding and
Includes formula deposition methods.

The wet wipes of the present invention can be prepared by applying the aqueous composition according to the present invention to a flexible, absorbent nonwoven substrate in a variety of well-known ways, such as by spraying, badging, printing, and gravity-loading methods. Preferably, the weight of the aqueous composition used is approximately twice the weight (200%) of the nonwoven support.
) to about 5 times (500%), more preferably about 3z times (350%) the weight of the nonwoven fabric support.

The aqueous compositions of the invention are conveniently prepared in the following manner.

All optional ingredients to be included in the composition, except the plant extract, are combined and mixed thoroughly until a clear mixture is obtained. The resulting mixture is stirred for 1 minute until it reaches about 95% of the prescription star.
% water and to this under stirring individually in the following order:
Add plant extract (if present), airtrium ethylenediaminetetraacetate, cationic hydroside and potassium sorbate. Then add enough Y to adjust the citric acid to pH 3.5-4.5 (into the pre-pressed hatch)
Add with The remaining water of Formulation V is then added with stirring.

The amount of water used in the composition is deionized water, but the secondary water may be an aqueous solution or concentrated m! It may be derived from certain commercially available products supplied as liquids, which are also acceptable.

The wet wipes of the present invention are used to clean living and/or inanimate surfaces or to provide them with active ingredients such as sunscreens, insect repellents, etc.

For example, they are used for cleaning the skin of the hands or other areas of the body, as baby wipes during diaper changes, and for cleaning various hard surfaces such as sink tops, toilet bowls, sinks, etc.

Temperature wipes (of the present invention) should be packaged in a manner that keeps them moist. Various well known packaging methods may be used.

For example, they can be packaged individually in moisture-impermeable containers or in bulk in canisters with suitable dispensing openings. When packaged in bulk, they can be supplied as separate sheets, for example with interleaf inserts, or in the form of a continuous sheet from which the individual sheets can be easily separated. In the latter case reference is made to US Pat. No. 4.017.002.

The invention is further illustrated by, but not limited to, the following examples.

Example 1 An aqueous composition according to the invention was formulated as follows according to the general method described above.

Ichisei Ichishot Propylene Glycol 0.500P
EG-60-7/phosphorus (50% 78 liquid)” 0
．． 100 Milanol C2M concentrate N P -P C0,
100 (38% active ingredient) b Fragrance? Loeheragel (1:10) c Cosmosol CQ (20% active ingredient) 6 Potassium dinorbate IE DTA Disodium dihydrate Citric acid Deionized water pH 4.1 0,,+75 0.010 0.700 0.140 o,to.

O,100 97,775 100,000 a) CTFA adopted name: Clodagh Co., Ltd. nine state New York) Kara Solan (SOLAN) 50 (Yes It is commercially available under the trade name 50% active ingredient).

h) Miranol (?15=A trademark)
, 38% water soluble? (1, (contains a small amount of propylene glycol)) Commercially available from 27 No. 1, Inc., Dayton, Jersey; the active ingredient is cocoamphodiacetate, which corresponds to the following formula.

RCO-NllC1lzCHJ-CllzCIlzOC
IIzCOzNaCIIzCOONa (,) Commercially available from Dr. N'dis Laboratories, Inc., New Jersey, USA as Veragel® Solution 1:10.

d) Polyhexamethylene biguanide hydrochloride; commercially available from ICI Americans (see general formula of active ingredient above).

The aqueous composition of Example 1 contains Staphylococcus aureus (Staph
ylococcus aureus), Psuedomonas product isolates, yeast product isolates and Aspergillus niger.
(illusniger) showed excellent antiseptic activity in a 4-week challenge.

A wet wipe according to the invention was prepared by soaking a flexible absorbent nonwoven support with 350% of its weight of the composition of Example 1. The gravity application method was adopted according to the following.

The aqueous composition of Example 1 (196 g) was placed in a cylindrical canister and a dry wipe (approximately 14.6 cm x 20.5 cm) was placed in a cylindrical canister.
3c+a, 5.75"X8.O") One end of a coreless roll of 56g made of 40 sheets of flexible absorbent nonwoven fabric was soaked in the body overnight and placed in a canister. The aqueous composition is then completely absorbed into the coreless roll of fabric.
and inverted to ensure even dispersion.
The inverted position was maintained for a minimum of 3 days. The canister was then inverted and stood upright.

The flexible absorbent nonwoven fabric used in the above method to make the wet wipes was a 70/30 blend of rayon and polyester fibers carded into a homogeneous web. The web was then coated with an acrylic binder (Rohm & Haas Company, Philadelphia, Pennsylvania) with Robrex (II).
hoplex) N W1402 product name (IFi)
The aqueous dilution was saturated.

The amount of binder was 20% W8 of the final nonwoven fabric. The treated web is then dried to about 149"C (
The binder was cured by heating to 300°F.

Next, the basic weight is about 41.8g/ld (40g/yd”
) was slit and cut to the desired size.

The wet wipes thus obtained are highly tolerable with respect to slippery contact, and during a 6-month attack test were tested against molds, Aspergillus niger and Hupencilium levium.
tum) was completely protected against 7G staining.

Example 2 An aqueous composition according to the invention was prepared similarly to Example 1. However, poly[oxyethylene (dimethyliminio)
Ethylene (dimethyliminio) or ethylene chloride (commercially available from Beckman Laboratories under the tradename WSCP - see above) was used in place of Cosmosil CQ based on the weight of active substance.

Example 1 using the aqueous composition of Example 2 as an impregnating agent
Preparation of wet wipes 61 A wet wipe was prepared from a support and a li gravity application method similar to that previously described. These pastes were also very acceptable in terms of slippery feel.

Seven aqueous compositions were prepared in the same manner as the aqueous composition of Example 1, but using the following seven commercially available hyosides in place of Cosmosil CQ based on the weight of active substance.

Kumishiro] Person: N-7/L/Kill (50% own, 40% C1
2+10%C16,) Dimethylhensyl ammonium chloride ■ Formation 1: Cetyl pyridinium chloride 1 Husk 2 Nididecyl dimethyl ammonium chloride rule Both conditions ■: 1-Hydroxyethyl-]-Hensyl chloride 1 possibility nE: Diisobutylphenoquine ethoxy Jedyldimethylhendyl ammonium chloride = i ■: Poly (
dimethylbutenyl ammonium chloride)-α,ω-bis-triethanolammonium chloride Composition G: Quaternium
-33, equivalent to the following formula, where lIC0- represents a lanolic acid residue.

Wet wipes use the above compositions A-G as impregnating agents;
It was prepared by using a support and gravity application method similar to that described above for the preparation of a wet wipe impregnated with the composition of Example 1. In both cases the resulting wet wipes had an unacceptable slippery feel, which prevented them from being commercially available.

Claims (1)

[Claims] 1. Potassium sorbate about 0.02 to about 0.25% by weight
, about 0.05 to about 0.20% by weight of citric acid, about 0.02 to about 0.20% by weight of airtrium ethylenediaminetetraacetate, (a) polyhexamethylene biguanide hydrochloride, or (b) poly[oxyethylene ( about 0.03 to about 0.24% by weight of a cationic biocide that is ethylene (dimethyliminio)ethylene (dimethyliminio)ethylene dichloride]
and the balance to 100% by weight water, wherein the pH of the composition is from about 3.5 to about 4.5. 2. The weight percent of potassium sorbate is about 0.140, the weight percent of citric acid is about 0.100, the weight percent of disodium EDTA is about 0.090, and the weight percent of cationic biocide. is about 0.140.
The composition described in . 3. Claim 1 or 2 further comprising a skin moisturizer, an emollient, a surfactant, or a mixture of these ingredients.
The composition described in . 4. The composition of claim 3, wherein the additional ingredients consist of about 0.500% by weight propylene glycol, about 0.050% by weight PEG-60 lanolin, and about 0.038% by weight cocoamphodiacetate. 5. The composition according to any one of claims 1 to 4, having a pH of about 4.0 to about 4.3. 6. The composition according to any one of claims 1 to 5, wherein the cationic biocide is polyhexamethylene biguanide hydrochloride. 7. Cationic biocide is poly[oxyethylene (
6. The composition according to claim 1, wherein the composition is ethylene (dimethyliminio)ethylene (dimethyliminio)ethylene dichloride. 8. A wet wipe comprising a flexible absorbent non-woven support impregnated with the aqueous composition according to any one of claims 1 to 7. 9. The wet wipe of claim 8, wherein the aqueous composition coverage on the support is from about 200 to about 500% by weight of the support. 10. The wet wipe of claim 9, wherein the aqueous composition coverage on the support is about 350% by weight of the support.