JPH08188517A - Sebum secretion inhibitor - Google Patents

Abstract

PURPOSE: To obtain the subject inhibitor high in safety to the skin, having ability to contract the sebaceous gland through its continuous use, containing an extract from bread yeast or the extract further added with an acidulant such as citric acid or lactic acid. CONSTITUTION: This sebum secretion inhibitor contains, as active ingredient, pref. 1-10wt.% of an extract of bread yeast (i.e., Saccharomyces cerevisiae) and, optionally, pref. 0.01-1wt.% of at least one kind of acidulant selected from citric acid, tartaric acid, lactic acid, malic acid, zinc p-phenolsulfonate, aluminum chlorohydroxide and tannin. The inhibitor is excellent in safety to the skin, contracts the sebaceous gland through improving the sebaceous gland through its continuous use, thereby improving the fatty skin through inhibiting sebum secretion.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention has excellent skin safety, and its continuous use improves the sebaceous gland to reduce the size of the sebaceous gland.
The present invention relates to a sebum secretion inhibitor that suppresses sebum secretion and improves oily skin.

[0002]

2. Description of the Related Art Many people with oily skin, who have a large amount of sebum secretion, have troubles such as sticky skin, easy acne, and easy breakup of makeup cosmetics. There is. To solve these problems, wash your face frequently, use astringent cosmetics containing organic acids, tannins and metal salts, use cosmetics containing female hormones such as estradiol, and remove retinoic acid. It has been practiced to externally apply a drug having an effect of shrinking the sebaceous glands.

[0003] However, repeated washing of the face causes an extremely small amount of sebum to easily cause rough skin, and the effect of the astringent cosmetic is temporary and does not last. Furthermore, the external use of female hormones is not sufficiently effective, and retinoic acid has a safety problem. As described above, there is currently no sebum secretion inhibitor that safely performs fundamental improvement of oily skin.

[0004] Therefore, as a result of intensive studies by the present inventors, a sebum secretion inhibitor containing an extract extracted from baker's yeast has excellent skin safety, and its continuous use improves sebaceous glands to improve sebaceous gland size. It has been found that it can shrink and suppress the secretion of sebum and improve oily skin.

Further, one or more kinds selected from the group of astringents consisting of citric acid, tartaric acid, lactic acid, malic acid, zinc paraphenolsulfonate, aluminum chlorohydroxide and tannin are additionally added to the sebum secretion inhibitor. In this case, they have found that the secretion of sebum can be more effectively suppressed by the synergistic action of drugs to improve oily skin, and the present invention has been completed.

That is, the sebum secretion inhibitor of the present invention is excellent in skin safety, and its continuous use improves the sebaceous gland to reduce the size of the sebaceous gland, suppresses the secretion of sebum, and improves oily skin. And

[0007]

[Means for Solving the Problems] To achieve the above object, claim 1 of the present invention is a sebum secretion inhibitor containing an extract of baker's yeast.

Further, claim 2 of the present invention further comprises at least one selected from the group of astringents consisting of citric acid, tartaric acid, lactic acid, malic acid, zinc paraphenolsulfonate, aluminum chlorohydroxide and tannin. The sebum secretion inhibitor according to claim 1, which is incorporated.

The structure of the present invention will be described in detail below. The baker's yeast extract used in the present invention is an extract of Saccharomyces cerevisiae , and this extract can be obtained by a usual method.

The baker's yeast used in the present invention may be any commercially available yeast extract, for example, yeast extract manufactured by Ebios, extract manufactured by BRROKS, and DIF.
CO yeast company extract, BIO-DELL company cytocatalyzer, etc. are mentioned.

The amount of the yeast extract blended is 0.1 to 30% by weight (hereinafter abbreviated as wt%) within the range in which the sebum secretion inhibitory effect is obtained, based on the total amount of the prescription components of the sebum secretion inhibitor. It is preferably 1 to 10 wt%.

Citric acid, tartaric acid, used in the present invention,
Lactic acid, malic acid, zinc paraphenolsulfonate and aluminum chlorohydroxide are known substances. The blending amount is based on the total amount of prescription components of the sebum secretion inhibitor,
Within the range where the sebum secretion inhibitory effect is obtained, 0.001
~ 3 wt% is preferable, and more preferably 0.01-1.
wt%.

The tannin used in the present invention includes an extract from a plant or a chemically synthesized product, and the extract from a plant includes persimmon tannin and the like, but is not limited thereto. For example, persimmon tannin can be obtained by the method described below.

The tannin content is preferably 0.001 to 2% by weight, more preferably 0.01 to 1% by weight, based on the total amount of the components of the sebum secretion inhibitor, which is within the range in which the sebum secretion inhibitory effect is obtained. Within the range of.

In the sebum secretion inhibitor of the present invention, in addition to the above-mentioned essential components, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, humectants, ultraviolet absorbers and the like are provided. Can be appropriately blended within a range that does not impair the above.

The formulation of the sebum secretion inhibitor of the present invention is as follows:
Examples include creams, emulsions, lotions, and packs. In the case of a milky lotion or the like, this cosmetic can be produced by an ordinary method of emulsifying and dispersing an oily phase and an aqueous phase, which are melted by heating, and cooling.

[0017]

EXAMPLES The present invention will be described in detail below based on Examples and Comparative Examples, but the present invention is not limited thereto. The sebum recovery test method, sebaceous gland inhibition test method, and sensory test method described in Examples are as follows.

(1) Sebum recovery test method A cup having a diameter of 2 cm is placed on the forehead, and sebum is extracted with 10 ml of ether for 1 minute. Apply 0.2g of sample to this area,
After resting at 25 ° C. for 1 hour, sebum is extracted by the same method. The ratio of the amount of sebum 2 hours after the application of the sample to the amount of sebum before the application of the sample is defined as the sebum recovery rate. The lower the sebum recovery rate, the higher the sebum-suppressing effect of the sample.

(2) Sebaceous Gland Inhibition Test Method The sample was applied to the backs of 10 rhino mice (Charles River Japan, Inc.) with developed sebaceous glands once a day for 3 weeks every day, and after 3 weeks, the epidermis was collected and sebaceous glands were collected. Was measured. The results were evaluated by the average value of 100 sebaceous glands, 10 per animal.

(3) Sensory test Twenty-five subjects continuously used the sample for 3 weeks, and after 3 weeks, the sebum improving effect and skin irritation were examined. The results are shown by the number of subjects who responded that the sebum was suppressed and there was irritation.

(4) Method for producing each essential component The method for producing the yeast extract and persimmon tannin used in the examples is not specified, but the outline of each method is described below.

[Preparation of Yeast Extract] Baker's yeast ( Saccharomyces cerevisiae ) Saccharomyces cerevisiae 1
Saccharose (500 g), sodium chloride (200 g) and magnesium sulfate (300 g) were added to 00 kg, and they were mixed well and acidified to pH.
After adjustment (4.2), it was left at 5 ° C. for 3 weeks. This was centrifuged, purified water was added to the resulting solution, and the solution was dialyzed with a cellophane tube for 2 days to remove proteins and filtered, and then the pH was adjusted to neutral (6.8) and concentrated under reduced pressure. Four
0 liter of yeast extract was obtained. These yeast extracts include nucleic acids and nucleic acid-related substances, various amino acids, vitamins, inorganic salts and the like.

[Preparation method of persimmon tannin] Dispyrous kaki Disperous kaki Tanberg (Evenache)
The fruit of thunberg ( Ebenaceae) is crushed, compressed, and juice is collected. Filter the solids of the fermented solution,
100 kg of the filtrate was dried to obtain 3 kg of persimmon tannin.

Examples 1 to 5 and Comparative Examples 1 to 7 The composition of Table 1 and the yeast extract and astringent of the present invention are shown in Table 2.
A skin cream was prepared according to the following preparation method.

[0025]

[Table 1]

[0026]

[Table 2]

(Preparation method) (A) at 70 ° C., B at 50 ° C.
Dissolve evenly in (A), inject (A) into (A) with stirring and emulsify and disperse, and then at a temperature of 5 with stirring.
Cool to 0 ° C, add (C), and stir at a temperature of 3
It was prepared by cooling to 0 ° C.

The evaluation test was carried out for the examples and comparative examples. Table 3 shows the results.

[0029]

[Table 3]

(Characteristics) As shown in Table 3, the skin creams of Examples 1 and 2 of the present invention were confirmed to have a sufficient sebum suppressing effect and were excellent in safety. Furthermore, in Examples 3 to 5 in which the astringent was additionally compounded, a higher sebum suppressing effect was recognized due to the synergistic effect. On the other hand, the skin creams of Comparative Examples 1 to 7 were inferior to those of the examples of the present invention because sufficient effects were not recognized.

Example 6 [Skin lotion] A skin lotion containing the components of the present invention having the composition shown in Table 4 was prepared by the following production method.

[0032]

[Table 4]

(Preparation Method) Components (A) and (B) were mixed and dissolved, and (B) was added to (A), followed by mixing and stirring.

(Characteristics) The skin lotion of Example 6 is
A sufficient sebum-suppressing effect was observed 3 weeks after the start of the test.

[0035]

Industrial Applicability As described above, the sebum secretion inhibitor of the present invention has excellent skin safety, and its continuous use improves the sebaceous gland to reduce the size of the sebaceous gland, suppresses the secretion of sebum, and reduces oily skin. The improvement is clear.

Claims (2)

[Claims] 1. A sebum secretion inhibitor containing an extract of baker's yeast. 2. The sebum according to claim 1, further comprising one or more selected from the group of astringents consisting of citric acid, tartaric acid, lactic acid, malic acid, zinc paraphenolsulfonate, aluminum chlorohydroxide and tannin. Secretory inhibitor.