JPH08126659A - Base material for medical care containing antifungal material and wound covering material - Google Patents

Abstract

PURPOSE: To obtain a wound covering material with antifungal properties, low in side effect and promoting epidermis formation by incorporating hydroxyapatite and/or silica gel carrying at least one kind of metal selected from a group of silver, copper and zinc with an adhesive substance in a substrate by means of covering, immersion, etc. CONSTITUTION: A wound covering material is prepd. by laminating a fibrous structural body, pref. a substrate consisting of CMC, an adhesive layer and a hydrophilic porous membrane, and an antifungal material is incorporated into at least one of the substrate, the adhesive layer and the hydrophilic porous layer by means of covering and/or immersion to exhibit antifungal properties. Curing of a wound position is performed by an action of the CMC fibrous structural body absorbing an exudate from the wound face and keeping an appropriate wet environment and a high steam and water permeable action of the hydrophilic porous membrane. In addition, on a wound face with possibility of infection such as a thermally wound face, infection caused by bacteria can be prevented from occurring by the antifungal material. In addition, there exists neither eluation of the antifungal metal ion nor coloring with time.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a medical base material having antibacterial properties and a wound dressing.

[0002]

2. Description of the Related Art Wound-protecting materials or materials for wounds such as traumatic skin wounds and skin wounds and wounds associated with diseases are roughly classified to keep the wounds in a dry state to prevent infection from the outside and leakage of body fluids. So-called dry dressing, which prevents and heals by crusting, and wet dressing, which creates an appropriate moist environment and rapidly migrates epidermal cells, are known. Although gypsum gauze can be said to be a representative material used in the dry dressing method, there are problems that gauze and new tissue adhere to each other and it is difficult to prevent contamination from the outside in wounds with a large amount of exudate. Further, although film dressing, which is one of the wet dressing methods, has water vapor permeability, it does not absorb water, and therefore, when a large amount of exudate is present, there is a possibility that bacteria may propagate due to the wet environment and the closed state. Therefore, at present, there are few medical base materials such as wound dressings having a function of preventing or suppressing infection.

On the other hand, the antibacterial topical agents currently used cause the development of resistant bacteria, the bacterial substitution phenomenon and the decrease of white blood cells and Ca, and the antibacterial material containing zeolite in an antibacterial metal is It has the drawback of discoloring after being added to the resin. Further, there is a problem that the antibacterial agent is dropped from the coating material containing the antibacterial material and directly contacts the living body to cause a foreign substance reaction.

[0004]

DISCLOSURE OF THE INVENTION The present invention is a medical treatment which has antibacterial properties, is excellent in stability over time, has no risk of discoloration, has few side effects on the living body, and promotes infection prevention, pain relief, and epidermal formation. An object is to provide a base material and a wound dressing.

[0005]

The above objects can be solved by the present invention described below. (1) Medical treatment characterized in that hydroxyapatite and / or silica gel supporting at least one metal selected from the group consisting of silver, copper and zinc are contained in a support together with an adhesive substance by coating, dipping or the like. Substrate. (2) The medical substrate according to (1) above, wherein the support is a fiber structure.

(3) The medical substrate according to the above (1) or (2), wherein the fibrous structure is at least one of woven fabric, non-woven fabric and knitted fabric. (4) The medical substrate according to the above (1) to (3), wherein the adhesive substance is a water-repellent substance.

(5) The medical substrate according to the above (1) to (4), wherein the water repellent substance is silicone. (6) The medical base material according to the above (1) to (5), wherein the material of the support is carboxymethyl cellulose, polyester, polyurethane, cotton, or rayon.

(7) A wound dressing material comprising a medical substrate as described in (1) to (6) above and a hydrophilic porous membrane laminated on the substrate. (8) Antibacterial material is 0.1-5.0 mg / c with respect to the support.
The wound dressing material according to (7) above, which contains m ² .

(9) Hydroxyapatite and / or silica gel carrying at least one metal selected from the group consisting of silver, copper and zinc is contained in an amount of 0.5 to 50% by weight based on the adhesive material. The wound dressing according to (7) to (8). (10) The wound dressing according to the above (7) to (9), wherein the hydrophilic porous membrane is made of polyolefin, halogenated polyolefin, or a mixture thereof.

The present invention uses, as an antibacterial material, hydroxyapatite and / or silica gel carrying at least one metal selected from the group consisting of silver, copper and zinc, and has antibacterial properties and stability over time (no discoloration). An excellent medical base material and wound dressing.

As the antibacterial material of the present invention, a material in which a metal ion such as silver, copper or zinc is carried on hydroxyapatite or silica gel by high temperature sintering at 1000 ° C. or more or ion exchange is used. At that time, the particle size of hydroxyapatite or silica gel is 0.1 to 5 μm, and the amount of metal ions is 0.001 relative to hydroxyapatite.
It is preferable that the content is up to 5% by weight. In particular,
Apacider (registered trademark, manufactured by Sangi Co., Ltd.) can be mentioned.

In the medical base material and wound dressing of the present invention, the support is not particularly limited, but is preferably a fibrous structure made of carboxymethyl cellulose (hereinafter referred to as CMC), polyester, polyurethane, cotton, or rayon. The structure has at least one structure of woven cloth, non-woven cloth and knitted cloth.

In the medical base material and wound dressing material of the present invention, the adhesive substance used for containing the antibacterial material on the support by coating, dipping or the like is not limited, but is preferably a water repellent substance, Specific examples thereof include silicone, polyurethane, styrene-butadiene-styrene block copolymer, and polytetrafluoroethylene. At that time, the amount of the adhesive substance, preferably the water-repellent substance, may be 5 to 20% by weight based on the fibrous structure. Further, the above-mentioned adhesive substance is also used for adhering the support and the hydrophilic porous membrane in the wound dressing of the present invention.

The hydrophilic porous membrane in the wound dressing of the present invention is not particularly limited, but may be polyethylene, polyolefin such as polypropylene, or polyvinylidene fluoride,
A porous membrane formed of polyvinylidene chloride, a halogenated polyolefin such as chlorinated polyethylene, or a mixture thereof is used, which is coated with a hydrophilic polymer. At that time, the hydrophilic polymer is not particularly limited,
Preferred examples include polymethoxyethyl acrylate,
Examples thereof include polydimethylacrylamide, methoxyacrylic acid ester copolymer, and dimethylacrylamide copolymer. The porous membrane has a pore size of 0.01 to 1.0 μm and a water vapor transmission rate (JIS standard) of 20 to 10000 g / m ² ·.
It is preferably 24 hours.

Further, in the wound dressing of the present invention, in order to impart elasticity to the hydrophilic porous membrane, it is preferable to impart elasticity by polymerizing an elastic polymer such as acrylate ester to the porous membrane. . At that time, the polymer having elasticity is not particularly limited as long as it can be imparted by a polymer reaction or graft polymerization, but n-butyl acrylate is preferable. Further, the elastic porous film has a pore size of 0.01 to 1.0 μm and a water vapor transmission rate of 200.
It is preferably from 10000 g / m ² · 24 hr.

In the medical base material and wound dressing material of the present invention, various properties can be given by changing the support. For example, when non-adhesive polyester or the like is used for the support, gauze does not adhere to the wound by directly using it as a primary dressing on the wound surface, and exudate can be quickly permeated. A medical base material and a wound dressing which can be prevented can be obtained.
Further, when CMC is used as the support, a medical base material that absorbs the exudate from the wound surface and can maintain an appropriate moist environment, and that can prevent infection and relieve pain with an antibacterial material, A wound dressing can be obtained.

The medical substrate of the present invention comprises a support and a water-repellent substance containing an antibacterial material as described above.
By replacing the base material used for the support, the wound site is covered and protected, the gauze does not stick to the wound surface, and the exudate permeates,
Healing can be promoted and exudate can be absorbed by water to maintain an appropriate moist environment and accelerate healing. Further, infection is suppressed by the antibacterial material contained in the water repellent material.

The method for producing the medical base material of the present invention is not particularly limited, but specifically, it is added to a solvent such as hexane, tetrahydrofuran, methyl ethyl ketone, diethyl ether or toluene, and an antibacterial material such as apacider (registered). Trademark, manufactured by Sangi Co., Ltd.), Bactenone (registered trademark, manufactured by Gel Technology Co., Ltd.), and an adhesive substance, preferably an adhesive substance which is a water repellent substance, such as silicone, polyurethane, styrene-butadiene-styrene block copolymer and polytetraoloethylene. The concentration 5
Approximately 20% by weight of dissolved adhesive substance solution is prepared, and polyester, polyurethane, cotton, rayon or C
A desired medical base material can be obtained by bringing a support made of MC into contact with the solution by applying it by dipping or spraying, using a roller or the like.

The wound dressing of the present invention comprises a support comprising a fibrous structure, preferably CMC, an adhesive layer and a hydrophilic porous membrane, which are laminated as described above, and the support, the adhesive layer and the hydrophilic layer are laminated. A wound dressing material having an antibacterial property, in which at least one of the porous membranes contains an antibacterial material by coating and / or dipping.

The wound dressing of the present invention absorbs the exudate from the wound surface of the CMC fibrous structure and maintains an appropriate moist environment, and the hydrophilic porous membrane has high water vapor permeation and water permeation. Healing of the wound site is performed. In addition, on the wound surface having a risk of infection such as a burn wound, infection by bacteria is prevented by the contained antibacterial material. Further, since the antibacterial metal ions are strongly adsorbed specifically on the hydroxyapatite or silica gel, the antibacterial metal ions do not elute and coloring does not occur over time.

Next, a method for manufacturing the wound dressing of the present invention will be described. Specifically, a highly hydrous gel-forming fiber structure such as a woven fabric, a non-woven fabric, or a knit fabric made of CMC is produced.
Then, in a suitable solvent, such as hexane, tetrahydrofuran, methyl ethyl ketone, diethyl ether, toluene, so as not to dissolve the resulting highly hydrous gel-forming fiber structure, an adhesive substance, preferably an adhesive substance that is a water-repellent substance, for example, silicone. , Polyurethane, styrene-butadiene-styrene block copolymer, polytetrafluoroethylene in a concentration of about 1 to 10% by weight to prepare a solution of an adhesive substance, and dip the high water content gel forming fiber structure in this solution, or spray, roller And the like, and the adhesive substance is adhered to the surface of the thin film of the highly hydrous gel-forming substance thin film, which is not in contact with the wound, and then the highly hydrous gel-forming fibrous structure to which the adhesive substance is adhered. When a hydrophilic porous polypropylene film is laminated on the It can be obtained of the wound dressing. The antibacterial material is previously contained in the adhesive substance or the adhesive substance solution.

[0022]

EXAMPLES The present invention will be described more specifically below with reference to examples.

Example 1 Apacider (registered trademark, manufactured by Sangi Co., Ltd.) or Bactenone (registered trademark, manufactured by Gel Technology Co., Ltd.) was used as the antibacterial material, and these antibacterial materials were used at a concentration of 2.0 mg / cm ^2. Was sufficiently dispersed in a hexane solution in advance and mixed with 5% of Medical Grade Silastic (registered trademark) silicone (adhesive type A, manufactured by Dow Corning). 5% containing the obtained antibacterial material
Add silicone hexane solution to polyester mesh (10
0 filaments / inch, multifilament) was coated (dipped).

(Example 2) As an antibacterial material, Apacider (registered trademark, manufactured by Sangi Co., Ltd.) or Bactenone (registered trademark, manufactured by Gel Technology Co., Ltd.) was used, and the concentration of these antibacterial materials was 2.0 mg / cm ^2. Was sufficiently dispersed in a hexane solution in advance and mixed with 5% of Medical Grade Silastic (registered trademark) silicone (adhesive type A, manufactured by Dow Corning). A 5% silicone hexane solution containing the above antibacterial material was applied to a cotton nonwoven fabric (Benlize, Asahi Kasei
Co., Ltd., unit weight 18.5g / m ² ) coating (diping)
did.

Example 3 As an antibacterial material, Apacider (registered trademark, manufactured by Sangi Co., Ltd.) or Bactenone (registered trademark, manufactured by Gel Technology Co., Ltd.) was used, and 0.25 to 2.0 mg of these antibacterial materials were used. Pre-dispersed in hexane solution at a concentration of / cm ² and 5% Medical Grade Silastic® silicone (adhesive type A,
Dow Corning). A 5% silicone hexane solution containing the above antibacterial material was used as a CMC non-woven fabric (manufactured by Tokai Senko Co., Ltd., basis weight 18.5 g / m ² , etherification degree 0.40).
Was coated (dipped).

(Test Example 1) Antibacterial test A solid medium (Muller Hinton Agar, M) was placed on a sterilized petri dish.
HA, DIFCO) was sprinkled at a rate of 20 ml / dishes, and Staphylococcus aureus (Staphylococcus aureus) and Pseudomonas aeruginosa (Pseudomonas aeruginosa), which had been pre-cultured as a plate, were uniformly smeared. The medical base material according to the present invention obtained in Examples 1, 2 and 3 was punched out into a sample having a size of 8 mmφ and placed at three locations per fixed medium plate. 1 at 37 ° C
After inversion culture for 8 hours, the presence or absence of an inhibition circle and the growth of bacteria on the contact surface were observed. The results are shown in Table 1. From the results, the antibacterial effect was confirmed.

[0027]

[Table 1]

(Example 4) As the hydroxyapatite supporting the antibacterial metal ion, Apacider (registered trademark, manufactured by Sangi Co., Ltd.) was used, and the above material was added to 2.0 m.
Pre-dispersed in a hexane solution at a concentration of g / cm ^{2 to} 5%
Medical Grade Silastic® Silicone (adhesive type A, Dow Corning). A 5% silicone hexane solution containing hydroxyapatite supporting the above-mentioned antibacterial metal ions was used as a commercially available CMC non-woven fabric (manufactured by Tokai Senko Co., Ltd., basis weight 18.5 g / m 2).
² , the degree of etherification is 0.40) and the thickness is about 1
An antibacterial CMC fiber structure of 00 μm was obtained.

The above-mentioned antibacterial CMC fiber structure was spread on a medical grade silastic (registered trademark) silicone (MDX4-4210, manufactured by Dow Corning) and heated at 60 ° C., and then polypropylene and liquid paraffin were added. Hydrophilization made by graft-polymerizing the polypropylene porous film obtained by melt-kneading and forming into a film shape, and then deparaffinizing and irradiating plasma under argon atmosphere, and then introducing methoxyethyl acrylate monomer. The wound dressing of the present invention was produced by slowly placing it on a porous polypropylene membrane to adhere it, and heating it again at 60 ° C.

Example 5 A commercially available non-woven fabric made of CMC (manufactured by Tokai Senko Co., Ltd., having an etherification degree of 0.40) was used as a 5% medical grade silastic (registered trademark) silicone (adhesive type A, Dow). (Corning Co., Ltd.) Antibacterial CMC with a thickness of about 100 μm immersed in a hexane solution for 10 seconds
A fibrous structure was obtained.

Medical grade silastic (registered trademark) obtained by spreading the above antibacterial CMC fiber structure containing 50% by weight of apacider (registered trademark, manufactured by Sangi Co., Ltd.) as hydroxyapatite supporting antibacterial metal ions. After standing still on silicone (MDX4-4210, Dow Corning) and heating at 60 ° C., it was slowly placed on and adhered to the hydrophilized porous polypropylene membrane obtained according to Example 1, and again 60 ° C. The wound dressing of the present invention was produced by heating the wound dressing.

Test Example 2 Antibacterial Test A solid medium (Muller Hinton Agar, M) was placed on a sterilized petri dish.
HA, DIFCO) was sprinkled at a rate of 20 ml / dishes, and Staphylococcus aureus (Staphylococcus aureus) and Pseudomonas aeruginosa (Pseudomonas aeruginosa), which had been pre-cultured as a plate, were uniformly smeared.

The wound dressing material according to the present invention obtained in Examples 4 and 5 was punched out into a sample having a size of 8 mmφ and placed at three locations per fixed medium plate. 1 at 37 ° C
After inversion culture for 8 hours, the presence or absence of an inhibition circle and the growth of bacteria on the contact surface were observed. Table 2 shows the results. From the results, the antibacterial effect was confirmed.

[0034]

[Table 2]

Test Example 3 Animal Experiment The wound dressing material according to the present invention obtained in Examples 4 and 5 was
The back of the rat is shaved and 20 × 2 using a dermatome
After preparing a 0 mm bark wound, it was attached thereto. The inflammatory property, the epidermalization rate and the healing state were observed, and the practicality as a wound dressing was evaluated. As a result, no particular adverse effects were found on the inflammatory property and the epidermalization rate.

(Test Example 4) Color Change with Time The wound dressing material according to the present invention obtained in Examples 4 and 5,
Instead of the antibacterial material of the present invention, Bactekiller (registered trademark, manufactured by Nichimen Co., Ltd.), which is an antibacterial material in which an antibacterial metal is added to zeolite, is produced in the same manner as in Examples 4 and 5. When the wound dressings (Comparative Examples 1 and 2) prepared above were left at room temperature for one week, the appearance of the wound dressings according to the present invention did not change, but the wound dressings of each Comparative Example turned brown.

[0037]

The medical base material and wound dressing of the present invention are
It has excellent antibacterial properties and stability over time. In addition, it suppresses pain when wounded with a skin defect, has excellent moisturizing properties on the wound surface, prevents infections such as ulcers and burn wounds, and promotes wound healing with less tissue damage. it can.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Mikio Koide 1500 Inoguchi, Nakai-cho, Ashigarakami-gun, Kanagawa Terumo Corporation

Claims (5)

[Claims] 1. A medical base material comprising a support containing at least one metal selected from the group consisting of silver, copper and zinc, and supporting hydroxyapatite and / or silica gel together with an adhesive substance. . 2. The medical substrate according to claim 1, wherein the support is a fiber structure. 3. The adhesive material is a water repellent material.
The medical base material according to any one of claims 1 to 3. 4. The medical base material according to claim 1, wherein the material of the support is carboxymethyl cellulose, polyester, polyurethane, cotton, or rayon. 5. A wound dressing obtained by laminating a hydrophilic porous membrane on the medical substrate according to claim 1.