JPH0791187B2 - L-ascorbic acid preparation - Google Patents

Description

TECHNICAL FIELD The present invention relates to a formulation of L-ascorbic acid or a salt thereof which is stable under use conditions when used as an additive for foods and feeds, and a method for producing the same. In particular, it relates to a preparation of L-ascorbic acid or a salt thereof which is difficult to elute in a medium containing water or the like.

"Prior Art" L-ascorbic acid and its salts are extremely important nutritionally, and deficiency causes anemia in humans.
It is known that bleeding from the gums, skin, and mucous membranes causes so-called scurvy, and that its deficiency causes serious illness not only in humans but also in land animals and aquatic animals. As a nutritional supplement for humans, it is added to the mixed feed in livestock and aquaculture.

L-ascorbic acid is used not only in nutritional aspects of humans and animals but also in the food industry as one of organic acids as an acidulant, an antioxidant, and a modifier for wheat flour.

Thus, L- which is significant in nutrition or food processing
The drawback of ascorbic acid and its salts is that they are very susceptible to oxidation. In particular, it is easily decomposed in an aqueous solution or in the presence of metals and various minerals.

Particularly, in recent years, as the cultivation of fish and the like has become popular, the use of artificial mixed feed for fish farming has increased and has become widespread.
Generally, fishes do not have indigenous bacterial groups that biosynthesize vitamins like land animals, and therefore it is necessary to add various vitamins to their feed during aquaculture.

However, the L-ascorbic acid (so-called vitamin C) added in this case is extremely unstable especially in the feed due to the coexistence of the contained liver powder, water, and minerals, and it is easily decomposed and disappeared to cause nutrition. The academic purpose cannot be achieved.

As a countermeasure against this, conventionally, by coating L-ascorbic acid or a salt thereof with a coating agent such as fats or oils and fats and an emulsifier, it is possible to prevent the decomposition of L-ascorbic acid or a salt thereof by blocking water, minerals, air and the like. Attempts have been made to do so. For example, as the coating agent, fats and oils and lecithin or fats and oils, melts of lecithin and glycerin fatty acid monoester (JP-A-53-127819), fats and oils,
A melt with a sucrose fatty acid ester (Japanese Patent Laid-Open No. 54-109962) can be mentioned.

"Problems to be solved by the invention" However, in these patent applications, coatings in which fats and oils and lecithin are used in combination as a coating often contain lecithin, and therefore often discolor when stored for a long time. The coating agent in which the sucrose fatty acid ester is used in combination has the drawback that the sucrose fatty acid ester is expensive.
Further, when the hardened oil of animal and vegetable oil is used alone as a coating agent, the coating performance is not sufficient, and in the presence of water, L-ascorbic acid is easily eluted, and the coating performance is insufficient.

"Means for Solving Problems" The present inventors develop a formulation of L-ascorbic acid and salts coated with fat and oil which has sufficient coating performance without using these so-called emulsifiers and the like. As a result of diligent research aimed at that, a mixture of fats and oils, glycerin fatty acid monoesters and fatty acids such as stearic acid was used as a coating agent, and when L-ascorbic acid was coated, an emulsifier such as lecithin or sucrose fatty acid ester was obtained. The present invention has been completed by finding a surprising effect that the coating performance (judged by the elution rate of the core substance) is improved even if it is not used.

In the present invention, L-ascorbic acid or a salt thereof has a melting point of
The L-ascorbic acid preparation is coated with a coating agent composed of a fat and oil at 50 to 80 ° C., a glycerin fatty acid monoester or a diester, and a fatty acid which is solid at room temperature.

As the core substance of the L-ascorbic acid preparation used in the present invention, not only L-ascorbic acid but also its salts are used. The salt of L-ascorbic acid is an alkali metal or alkaline earth metal salt such as sodium salt or calcium salt. These L-ascorbic acids and salts thereof can be used alone or as a mixture.

The average particle size of the core substance is generally 80 μm or less, preferably 30 μm or less, and more preferably 3 to 20 μm.
m. If the particle size is large, the coating is insufficient, and if it is too small, it is not economical.

The fats and oils having a melting point of 50 to 80 ° C. used in the present invention include beef tallow oil, hardened chicken oil, hardened rapeseed oil, hardened oil of castor oil, hardened oil of whale oil, hardened oil of palm oil, hardened oil of soybean oil, coconut oil, etc. is there.

The glycerin fatty acid ester in the present invention can be selected from glycerin fatty acid monoester or diester or one or more of them. The fatty acid component preferably has 8 to 22 carbon atoms, and the fatty acid of the glycerin fatty acid ester may be saturated or unsaturated, but a saturated fatty acid glyceride is generally used. Examples of the glycerin fatty acid ester include lauric acid monoester, myristic acid monoester, palmitic acid monoester, stearic acid monoester and the like, or lauric acid diester,
Examples thereof include diesters such as myristic acid diester, palmitic acid diester, and stearic acid diester. Generally, practical commercial products are produced by the transesterification method of edible oil and fat and glycerin. According to this method, a monoester content of 48 to 69% and a balance of mainly diglyceride are obtained, and in order to further increase the monoester content, molecular distillation is performed to obtain a monoester content of 90% or more. These commercial products are mixed monoglycerides of two or more of the above fatty acid components. As the glycerin fatty acid ester of the present invention, any of these monoesters or a mixture of a monoester and a diester can be used, but a monoester as a main component is preferable.

The fatty acid used in the present invention is preferably solid at room temperature, usually having a melting point of 40 ° C. or higher and a carbon number of 12 to 22, and among these fatty acids, particularly stearic acid, palmitic acid,
Myristic acid and lauric acid are suitable, but a mixture thereof may be used.

The amount of glycerin fatty acid ester and fatty acid used is 1 to 3 parts by weight of glycerin fatty acid ester per 100 parts by weight of fats and oils.
0 to 20 parts by weight of fatty acid, usually 4 to 20 parts by weight of glycerin fatty acid ester and 2 to 10 parts by weight of fatty acid, preferably 4 to 10 parts by weight of glycerin fatty acid ester and 2 to 8 parts by weight of fatty acid. Is. Coating effect when the amount of glycerin fatty acid ester and fatty acid used is small (for example, the result of so-called dissolution test, which examines the extent to which core substance is dissolved in water)
Is poor, and if it is too large, the elution rate decreases. Fatty acids are particularly effective in improving the coating performance when the amount of glycerin fatty acid ester used is 4 parts by weight or more per 100 parts by weight of fat.

The coating agent consists of fats and oils having a melting point of 50 to 80 ° C, glycerin fatty acid monoester and fatty acid, which are usually mixed,
Used by heating and melting. The amount of this coating used is 0.5 to 2 with respect to the core substance L-ascorbic acid or its salt.
It is 0 times by weight, usually 1 to 10 times by weight, preferably 2 to 5 times by weight.

As the method for producing the L-ascorbic acid preparation of the present invention, there are known coating methods such as a spray cooling method or a method of spraying a coating agent solution dissolved in an organic solvent while flowing a core substance and granulating while evaporating the solvent. Examples of the methods include, but industrially, the spray cooling method is preferable. For example, the coating material is heated and melted at 70 to 80 ° C., a core substance is added to this, and the mixture is uniformly dispersed, and then 40 ° C. or less by a rotary disk type granulator, preferably 35 ° C. or less Most of particle size is about 200-700μ
m, preferably 200 to 500 μm. In order to make the particle diameters of the coating material uniform, the obtained coating material can be sieved in a desired particle diameter range.

"Action" The L-ascorbic acid preparation of the present invention can be used as a drug for improving the quality of medicines, foods, livestock and feed for farmed fish, or as an L-ascorbic acid (vitamin C) enhancer, but is not added. Even if the product, for example, the food or feed raw material is in a dry state or in a state of containing water, the object can be sufficiently achieved by easily adding and mixing.

Moreover, it is possible to add other base materials such as minerals that decompose L-ascorbic acid.

"Effects of the Invention" The L-ascorbic acid preparation of the present invention exhibits extremely industrially important effects capable of effectively exhibiting the original coating effect of fats and oils without using an expensive emulsifier with a cheaper raw material than before. be able to.

Next, the present invention will be described in detail with reference to examples. However, "parts" and "%" in the examples represent "parts by weight" and "% by weight" unless otherwise specified.

"Examples" Examples 1 to 3 100 parts hydrogenated beef tallow oil and glycerin fatty acid monoester (total monoglyceride content 95% or more; fatty acid components are 20 to 30% myristic acid, 60 to 70% stearic acid are commercially available products) and No. 1 The average particle size was 20μ when the coating agent consisting of fatty acid (stearic acid) in the ratio shown in the table was melted and kept at a temperature of 80 ° C.
m L-ascorbic acid crystal particles with a core substance content of about 30
%, And mix evenly and spray into a room at 25-35 ° C with a rotating disk sprayer, and then sieve to 300-400 μm.
To obtain a coating (L-ascorbic acid preparation).

The performance of the obtained coating was measured by measuring the elution rate shown in Experimental Examples. The results are shown in Table 1.

Comparative Examples 1 to 5 As coating agents, hydrogenated tallow oil containing only glycerin fatty acid monoester (similar to Example 1) or only fatty acid (addition ratio is shown in Table 2), and tallow hardening The same procedure as in Examples 1 to 3 was performed except that only oil was used.

Experimental Example After coating the coatings of Examples 1 to 3 and Comparative Examples 1 to 5 for 1 day at room temperature after granulation, the following test was performed on the elution rate of the coatings.

Using a shaker capable of shaking at 110 times / minute and reciprocating vibration with an amplitude of 50 mm, put the coating and water containing about 80 times the amount of stabilizer in a glass container, shake at 30 ° C for 30 minutes, and use a core. The elution rate of the substance was examined and the following results were obtained.

Example 4 Instead of L-ascorbic acid in Examples 1 to 3, L was used.
-Similar results were obtained using the calcium salt of ascorbic acid.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Hisashi Harada, No. 1-2 Chidori-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa Kawasaki Chemical Industry Co., Ltd. No. 2 Kawasaki Chemical Industry Co., Ltd. Examiner Tomoko Saeki

Claims (12)

[Claims] 1. A coating agent comprising L-ascorbic acid or a salt thereof, comprising a fat and oil having a melting point of 50 to 80 ° C., a glycerin fatty acid ester selected from the group consisting of glycerin fatty acid monoesters or diesters, and a fatty acid solid at room temperature. A coated L-ascorbic acid preparation. 2. A coating agent comprising 100 parts of fats and oils having a melting point of 50 to 80 ° C., 1 to 30 parts by weight of glycerin fatty acid ester and 2 to 20 of fatty acids.
The L-ascorbic acid preparation according to claim 1, which is parts by weight. 3. A coating agent comprising 100 parts of fats and oils having a melting point of 50 to 80 ° C., 4 to 20 parts by weight of glycerin fatty acid ester and 2 to 10 of fatty acids.
The L-ascorbic acid preparation according to claim 1, which is parts by weight. 4. A coating agent having a melting point of 50 to 80 ° C., 100 parts of fats and oils, 4 to 10 parts by weight of glycerin fatty acid monoester and 2 parts of fatty acid.
The L-ascorbic acid preparation according to claim 3, which is -8 parts by weight. 5. The L-ascorbic acid preparation according to claim 1, wherein the fat or oil is hydrogenated oil. 6. The fat and oil is hydrogenated beef tallow, hardened chicken oil, hardened rapeseed oil, hardened castor oil, hardened whale oil, hardened palm oil, hardened soybean oil, coconut oil. L-ascorbic acid preparation. 7. A glycerin fatty acid ester such as lauric acid monoester, myristic acid monoester, palmitic acid monoester, stearic acid monoester, etc., lauric acid diester, myristic acid diester, palmitic acid diester, stearic acid diester, etc. L as claimed in claim 1, which is a diester
-Ascorbic acid formulation. 8. A glycerin fatty acid ester as a main component, which is a glycerin fatty acid monoester.
The L-ascorbic acid preparation according to the item 2, 3, 4 or 7. 9. The L-ascorbic acid preparation according to claim 1, wherein the fatty acid has 12 to 22 carbon atoms. 10. The fatty acid is stearic acid, palmitic acid,
The L-ascorbic acid preparation according to claim 1, which is myristic acid or lauric acid. 11. The L- according to claim 1, wherein the particle size of L-ascorbic acid or a salt thereof is 3 to 20 μm.
Ascorbic acid preparation. 12. The particle size of the L-ascorbic acid preparation is 200-5.
The L-ascorbic acid preparation according to claim 1, which has a size of 00 μm.