JPH0791186B2 - L-ascorbic acid preparation - Google Patents

Description

TECHNICAL FIELD The present invention relates to a formulation of L-ascorbic acid or a salt thereof which is stable under use conditions when used as an additive for foods and feeds, and a method for producing the same. In particular, it relates to a preparation of L-ascorbic acid or a salt thereof which is difficult to elute in a medium containing water or the like.

"Prior Art" L-ascorbic acid and its salts are extremely important nutritionally, and deficiency causes anemia in humans.
It is known that bleeding from the gums, skin and mucous membranes causes so-called scurvy, and that its deficiency causes serious illness not only in humans but also in land animals and aquatic animals. For this reason, it is added to humans as a nutritional supplement, and is added to the mixed feed in livestock and aquaculture.

L-ascorbic acid is used not only in nutritional aspects of humans and animals but also in the food industry as one of organic acids as an acidulant, an antioxidant, and a modifier for wheat flour.

Thus, L- which is significant in nutrition or food processing
The drawback of ascorbic acid and its salts is that they are very susceptible to oxidation. In particular, it is easily decomposed in an aqueous solution or in the presence of metals and various minerals.

Particularly, in recent years, as the cultivation of fish and the like has become popular, the use of artificial mixed feed for fish farming has increased and has become widespread.
Generally, fishes do not have indigenous bacterial groups that biosynthesize vitamins like land animals, and therefore it is necessary to add various vitamins to their feed during aquaculture.

However, the L-ascorbic acid (so-called vitamin C) added in this case is extremely unstable especially in the feed due to the coexistence of the contained liver powder, water, and minerals, and it is easily decomposed and disappeared to cause nutrition. The academic purpose cannot be achieved.

As a countermeasure against this, conventionally, by coating L-ascorbic acid or a salt thereof with a coating agent such as fats or oils and fats and an emulsifier, it is possible to prevent the decomposition of L-ascorbic acid or a salt thereof by blocking water, minerals, air and the like. Attempts have been made to do so. Examples of the coating agent include fats and lecithin or fats and oils, melts of lecithin and glycerin fatty acid monoesters (JP-A-53-127819), and melts of oils and sucrose fatty acid esters (JP-A-54-109962). To be

"Problems to be solved by the invention" However, in these patent applications, coatings in which fats and oils and lecithin are used in combination as a coating often contain lecithin, and therefore often discolor when stored for a long time. The coating agent in which the sucrose fatty acid ester is used in combination has the drawback that the sucrose fatty acid ester is expensive.
Further, when the hardened oil of animal and vegetable oil is used alone as a coating agent, the coating performance is not sufficient, and in the presence of water, L-ascorbic acid is easily eluted, and the coating performance is insufficient.

“Means for Solving Problems” The present inventors have developed a formulation of L-ascorbic acid and salts coated with fats and oils having sufficient coating performance without using these so-called emulsifiers and the like. As a result of earnest research for the purpose of adding L-ascorbic acid to the fat by adding a smaller amount than the amount of glycerin fatty acid monoester described in the comparative example of the above-mentioned JP-A-53-127819 to the coating, The present invention has been completed by finding a surprising effect that the performance (determined by the elution rate of the core substance) is improved.

In the present invention, L-ascorbic acid or a salt thereof has a melting point of
The L-ascorbic acid preparation comprises a coating agent comprising 100 parts of fats and oils at 50 to 80 ° C. and 1 to 8 parts by weight of glycerin fatty acid ester selected from the group consisting of glycerin fatty acid monoester or diester.

As the core substance of the L-ascorbic acid preparation used in the present invention, not only L-ascorbic acid but also its salts are used. The salt of L-ascorbic acid is an alkali metal or alkaline earth metal salt such as sodium salt or calcium salt. These L-ascorbic acids and salts thereof can be used alone or as a mixture.

The average particle size of the core substance is generally 80 μm or less, preferably 30 μm or less, and more preferably 3 to 20 μm.
m. If the particle size is large, the coating is insufficient, and if it is too small, it is not economical.

The fats and oils having a melting point of 50 to 80 ° C. used in the present invention include beef tallow oil, hardened chicken oil, hardened rapeseed oil, hardened oil of castor oil, hardened oil of whale oil, hardened oil of palm oil, hardened oil of soybean oil, coconut oil, etc. is there.

The glycerin fatty acid ester in the present invention is also used as a monoester, a diester or a mixture thereof, and one or more kinds are appropriately selected from the group of various compounds thereof. The fatty acid component preferably has 8 to 22 carbon atoms and may be saturated or unsaturated. Generally, glyceride of saturated fatty acid is used. Examples of the glycerin fatty acid ester include monoesters such as lauric acid monoester, myristic acid monoester, palmitic acid monoester and stearic acid monoester, or diesters such as lauric acid diester, myristic acid diester, palmitic acid diester and stearic acid diester. However, general practical commercial products are produced by the transesterification method between edible oil and fat and glycerin. With this method, a monoester content of 48-69% and the balance mainly diglyceride can be obtained. To further increase the monoester content, 90% can be obtained by molecular distillation.
The above is obtained. These commercial products are 2 of the above fatty acids.
It is a mixed monoglyceride of more than one kind and is preferably used in the present invention. As the glycerin fatty acid ester of the present invention, any of these monoesters or a mixture of monoester and diester can be used.

The glycerin fatty acid ester is used in an amount of 1 to 10 parts by weight, usually 1 to 8 parts by weight, and preferably 100 parts by weight of fats and oils.
1.5 to 7.5 parts by weight, more preferably 1.5 to 4. parts by weight. If the amount of glycerin fatty acid monoester used is small, the coating effect (for example, to examine the extent to which the core substance is eluted in water,
The so-called dissolution rate test result) is poor, and if it is too large, the coating effect (dissolution rate) decreases.

The coating agent is composed of fats and oils having a melting point of 50 to 80 ° C. and the above-mentioned glycerin fatty acid ester, which are usually mixed and heated and melted before use. The amount of the coating agent used is 0.5 to 20 times the weight of the core substance L-ascorbic acid or its salt,
It is usually 1 to 10 times by weight, preferably 2 to 5 times by weight.

As the method for producing the L-ascorbic acid preparation of the present invention, there are known coating methods such as a spray cooling method or a method of spraying a coating agent solution dissolved in an organic solvent while flowing a core substance and granulating while evaporating the solvent. Examples of the methods include, but industrially, the spray cooling method is preferable. For example, the coating material is heated and melted at about 70 to 80 ° C., the core substance is added to this, and the mixture is uniformly dispersed.
It is sprayed into a room adjusted to 40 ℃ or less, preferably 35 ℃ or less by a rotary disk type granulator, and most of the particle size is about 200 to 700.
A method of granulating to a fine particle size of μm, preferably 200 to 500 μm is adopted. The particle size of the coating can be, for example, sieved so that the particle size falls within a preferable range in consideration of coating performance.

"Action" The L-ascorbic acid preparation of the present invention can be used as a drug, a food, a quality improver of feed for domestic animals and farmed fish, an L-ascorbic acid (vitamin C) reinforcing agent, etc. It is possible to achieve the object sufficiently by easily mixing even a product such as a food or feed material in a dry state or a state containing water.

Moreover, it is possible to add other base materials such as minerals that decompose L-ascorbic acid.

"Effects of the Invention" The L-ascorbic acid preparation of the present invention exhibits extremely industrially important effects capable of effectively exhibiting the original coating effect of fats and oils without using an expensive emulsifier with a cheaper raw material than before. be able to.

Next, the present invention will be described in detail with reference to examples. However, "parts" and "%" in the examples represent "parts by weight" and "% by weight" unless otherwise specified.

[Examples] Examples 1 to 4 Hydrogenated beef tallow oil and glycerin fatty acid monoesters in a ratio of 1 part, 2 parts, 3 parts and 5 parts to 100 parts of this oil and fat (total monoglyceride content 95% or more, myristic acid 20 to 30
%, A coating material consisting of 60 to 70% of stearic acid) is melted and kept at a temperature of 80 ° C., while L-ascorbic acid crystal particles having an average particle diameter of about 20 μm have a core substance content of about 30%. And then mix evenly and spray with a rotary disk type sprayer into a room at 25-35 ℃, and sieve to 200-600μm.
Coated particles having an average particle size of 380 μm were obtained.

Example 5 Hardened beef tallow oil and glycerin fatty acid monoester in a ratio of 2 parts to 100 parts of this fat and oil (total monoglyceride content 61
~ 66%, most of the rest is diglyceride; fatty acid composition is 20-30% myristic acid, 55-65% stearic acid
(Commercially available product) consisting of
The L-ascorbic acid crystal particles having an average particle size of 20 μm were added to the mixture so that the core substance content was about 30%, and the mixture was mixed uniformly and kept in a room at 25 to 35 ° C. in a rotary disk type sprayer. Was sprayed on and sieved to obtain a coating (L-ascorbic acid preparation) having an average particle size of about 380 μm.

In order to test the coating performance of this coating, the elution rate was measured by the method of Experimental Example.

Comparative Examples 1-2 The same procedure as in Example 1 was carried out except that the glycerin fatty acid monoester was not added in Example 1 and the amount of the glycerin fatty acid monoester was 14 parts based on 100 parts of the fat or oil.

Experimental Example After coating the coatings of Examples 1 to 5 and Comparative Example for 1 day at room temperature after granulation, the following test was performed on the elution rate of the coatings.

Using a shaker capable of shaking at 110 times / minute and reciprocating vibration with an amplitude of 50 mm, put the coating and water containing about 80 times the amount of stabilizer in a glass container, shake at 30 ° C for 30 minutes, Filtered,
The L-ascorbic acid content in the filtration station was quantified to measure the elution rate of the core substance, and the results shown in Table 1 below were obtained.

Example 6 In Examples 1 to 6, similar results were obtained by using a calcium salt of L-ascorbic acid instead of L-ascorbic acid.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Hisashi Harada, No. 1-2 Chidori-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa Kawasaki Chemical Industry Co., Ltd. No. 2 Kawasaki Chemical Industry Co., Ltd. Examiner Tomoko Saeki

Claims (10)

[Claims] 1. Coating of L-ascorbic acid or a salt thereof with 100 parts of fats and oils having a melting point of 50 to 80 ° C. and 1 to 10 parts by weight of glycerin fatty acid ester selected from the group consisting of glycerin fatty acid monoester or diester. An L-ascorbic acid preparation coated with an agent. 2. The amount of glycerin fatty acid ester is 100
Claims 1 to 8 parts by weight with respect to parts by weight
The L-ascorbic acid preparation according to the item. 3. The amount of glycerin fatty acid ester is 100.
The L-ascorbic acid preparation according to claim 1, which is 1.5 to 7.5 parts by weight based on parts by weight. 4. The amount of glycerin fatty acid ester is 100
The L-ascorbic acid preparation according to claim 1, which is 1.5 to 4.5 parts by weight with respect to parts by weight. 5. The L-ascorbic acid preparation according to claim 1, wherein the fat or oil is hydrogenated oil. 6. The fat and oil is hydrogenated beef tallow, hardened chicken oil, hardened rapeseed oil, hardened castor oil, hardened whale oil, hardened palm oil, hardened soybean oil, coconut oil. L-ascorbic acid preparation. 7. A glycerin fatty acid ester such as lauric acid monoester, myristic acid monoester, palmitic acid monoester, stearic acid monoester, etc., lauric acid diester, myristic acid diester, palmitic acid diester, stearic acid diester, etc. L as claimed in claim 1, which is a diester
-Ascorbic acid formulation. 8. The glycerin fatty acid ester is a glycerin fatty acid monoester, claims 1, 2, 3,
The L-ascorbic acid preparation according to item 4 or 7. 9. The L according to claim 1, wherein L-ascorbic acid or a salt thereof has an average particle size of 3 to 20 μm.
-Ascorbic acid formulation. 10. The particle size of the L-ascorbic acid preparation is 200-5.
The L-ascorbic acid preparation according to claim 1, which has a size of 00 μm.